p15. unilateral pedicle screw instrumentation in minimally invasive lumbar fusion
TRANSCRIPT
108S Proceedings of the NASS 23rd Annual Meeting / The Spine Journal 8 (2008) 1S–191S
STUDY DESIGN/ SETTING: Prospective, nonrandomized consecutive
series of patients undergoing surgery by a single surgeon.
PATIENT SAMPLE: Forty-two consecutive patients with painful DLS age
68 years(47-85 years) underwent posterior instrumented reduction/fusion
and ALIF in 21 patients at average 4.2 levels (3-6 levels) or TLIF in 21 at av-
erage 2.7 levels (1-4 levels). The decision of ALIF vs. TLIF was surgeon
preference. ALIF group curves were larger (34� vs 27�) with less lordosis
(25� vs 45�) pre-op. Follow-up averaged 38 months (24-68 months).
OUTCOME MEASURES: Oswestry Disability Index (ODI), visual ana-
log pain scores (VAS), and pain medication use were followed. Radiograph
measurements included the main scoliosis curvature, T12-S1 lordosis, cor-
onal and sagittal spinal balance, and pelvic incidence. Fusion was defined
as bridging bone on imaging without implant loosening and !3mm motion
on flexion-extension.
METHODS: Indications for surgery included painful stenosis, rotational
listhesis, or spinal imbalance failing O6 months conservative care. Cages
and BMP-2 were used in TLIF, and structural allograft or cages and
BMP-2 in ALIF. Posterior arthrodesis was achieved with local autograft
and allograft. The deformity in both groups was corrected by a combination
of direct translation, derotation, and compression/distraction on 5.5mm ti-
tanium rods. Posterior constructs averaged 6.8 levels(4-9 levels) for both
groups. Clinical and radiographic data was collected pre-op and post-op
6 weeks, 1 year, 2 years, and latest follow-up.
RESULTS: The ALIF group had 3 nonunions, 3 adjacent level fractures, 3
revisions for adjacent level degeneration, 3 infections, and one footdrop.
Revision surgery was performed in 8/21. Medical complications in this
group included 1 each pulmonary embolus, ileus requiring temporary co-
lostomy, and stroke. The TLIF group had 1 each infection, nonunion, ad-
jacent segment degeneration, transient footdrop, and additional surgery to
adjust coronal balance, with 3/21 requiring revision surgery. VAS for both
groups were similar: TLIF 6.7 pre-op(3-10) improved to 2.9(1-8), and
ALIF 6.5pre-op(0-10) improved to 2.9(1-7). Pain medication usage de-
clined post-op for both groups. Oswestry outcomes were also similar: TLIF
46.9(18-66) pre-op improved to 25.5(18-36), and ALIF 52.0(28-82) im-
proved to 31.0(0-64). Curve correction was similar: ALIF group curves
of 34�(13-49�) pre-op correcting 70% to 10�(0-18�). TLIF group curves
of 27�(14-64�) pre-op corrected 70% to 8�(0-22�). Lordosis improvement
was similar for both groups.
CONCLUSIONS: With current deformity correction techniques, both
ALIF and TLIF are effective adjuncts in DLS surgery, with similar defor-
mity correction and fusion rates. However, the complications with poste-
rior-only surgery for DLS appear to be significantly fewer.
FDA DEVICE/DRUG STATUS: This abstract does not discuss or include
any applicable devices or drugs.
doi:10.1016/j.spinee.2008.06.255
P14. Which is the Best Fusion Approach? A Nationwide Perspective
to the Surgical Treatment of Diffuse Cervical Spondylosis
Mohammed Shamji, MD, MSc1, Chad Cook, PT, PhD, MBA2,
Ricardo Pietrobon, MD, PhD, MBA2, Sean Tackett, BS2,
Christopher Brown, MD2, Robert Isaacs, MD2; 1Duke University, Durham,
NC, USA; 2Duke University Medical Center, Durham, NC, USA
BACKGROUND CONTEXT: Cervical spine fusion is performed for
various indications in patient populations ranging from young and
healthy to aged and frail. The choice of surgical approach is affected
by disease pathoanatomy, but also by age, medical comorbidities, and
the number of involved levels. Anterior fusion is more common for sin-
gle-level pathology in relatively young, healthy patients; and posterior
fusion is typically performed on older, more comorbid patients with mul-
tilevel disease. Consequently, retrospective comparisons of surgical ap-
proaches for cervical fusion will be impacted by this bias, and the
optimal management of multilevel cervical spine pathology remains
ambiguous with surgeon preference and experience playing a significant
role in choice of procedures.
PURPOSE: To define the levels of complications and resource utilization
related to multilevel cervical spine fusion surgery, and to evaluate the im-
pact of surgical approach on these outcomes.
STUDY DESIGN/ SETTING: A retrospective nationwide database study
of inpatient perioperative complications.
PATIENT SAMPLE: All patients undergoing multilevel (four to eight
levels) cervical spine fusion for degenerative disease between 2003 and
2005 at institutions represented in the Nationwide Inpatient Sample
database.
OUTCOME MEASURES: Measures of patient periprocedural mortality,
selected specific morbidities, and resource utilization were evaluated. Re-
source utilization included length of hospitalization, inflation-adjusted
cost, and likelihood of non-routine discharge to assisted living.
METHODS: Data for 8548 patients who underwent cervical fusion of
four to eight levels was collected from the Nationwide Inpatient Sample
database (2003-2005), and subjects were grouped by surgical approach
(anterior versus posterior). Descriptive statistics were used to compare
baseline characteristics, and bivariate analysis and logistic regression mod-
eling were used to evaluate the effect of surgical approach on mortality,
selected postoperative complications, length of stay, hospitalization cost,
and discharge disposition.
RESULTS: This observational study indicates that a posterior approach to
multilevel cervical fusion is associated with more respiratory complica-
tions, postoperative infections, symptomatic hematomas, and transfusions
when compared to an anterior approach. Resource utilization was nearly
double for those undergoing a posterior approach, including hospital length
of stay, inflation-adjusted cost, and likelihood of discharge to an assisted-
living facility. Not surprisingly, this study confirms that patients fused pos-
teriorly had a lower incidence of symptomatic postoperative dysphagia.
CONCLUSIONS: This nationwide study defines the incidence of mortal-
ity and the frequency of inpatient complications encountered during mul-
tilevel cervical fusion. The results suggest that immediate morbidity from
anterior approaches is less than those undergoing posterior fusion. Pro-
spective analysis is required to evaluate if these findings remain significant
in a randomized study population. Further, these results represent only
perioperative complications. However, based on the data presented herein,
when confronted with the patient requiring a four-level cervical fusion, the
anterior approach may offer an less risky and less costly option.
FDA DEVICE/DRUG STATUS: This abstract does not discuss or include
any applicable devices or drugs.
doi:10.1016/j.spinee.2008.06.256
P15. Unilateral Pedicle Screw Instrumentation in Minimally Invasive
Lumbar Fusion
Graham Hall, BS1, Jean-Pierre Mobasser, MD2; 1Indiana University,
Indianapolis, IN, USA; 2Indianapolis Neurosurgical Group, Indianapolis,
IN, USA
BACKGROUND CONTEXT: Bilateral pedicle screw instrumentation
has become a widely accepted technique for stabilization during single
level lumbar fusion. There is very little scientific data assessing whether
unilateral instrumentation could provide adequate stability for the inter-
body fusion process to occur.
PURPOSE: The purpose of this study is to assess whether unilateral screw
placement has an equivalent efficacy to bilateral screw placement in allow-
ing bone fusion to occur. If unilateral screw placement is proven to be
equivalent, then using this approach will: reduce patient morbidity, reduce
blood loss, decrease operative times, reduce cost, and result in less post-
operative pain.
STUDY DESIGN/ SETTING: This is a retrospective review looking at
follow up computed tomography scans 6–12 months after a minimally
109SProceedings of the NASS 23rd Annual Meeting / The Spine Journal 8 (2008) 1S–191S
invasive transforminal lumbar interbody fusion with unilateral percutaneous
pedicle screw instrumentation. Off-label use of rhBMP-2 was performed in
the interbody space in all cases.
PATIENT SAMPLE: 21 patients with unilateral instrumentation have had
follow up computed tomography scans in the 6–12 month post-operative
period to assess fusion.
OUTCOME MEASURES: This is a purely radiographic analysis to as-
sess interbody fusion with unilateral instrumentation. Independent neurora-
diologists reviewed all computed tomography scans and analyzed the
interbody fusion.
METHODS: All post-operative ct scans were performed at the same hos-
pital and 1mm slices with reformatted images were utilized to assess
fusion.
RESULTS: All 21 patients showed radiographic evidence of fusion be-
tween 6–12 months post-operatively. There were no non-unions observed
in this group of patients.
CONCLUSIONS: Unilateral pedicle screw instrumentation provides ade-
quate stability for the interbody fusion to occur.
FDA DEVICE/DRUG STATUS: Pedicle screw device: Approved for this
indication; rhBMP-2: Not approved for this indication.
doi:10.1016/j.spinee.2008.06.257
P16. Multi-level Posterior Vertebral Osteotomy for Correction of
Severe and Rigid Neuromuscular Scoliosis: A Preliminary Study
Hitesh Modi, MS, Seung-Woo Suh, MD, PhD, Yang Jae-Hyuk, MD;
Scoliosis Research Institute, Korea University Guro Hospital, Seoul, South
Korea
BACKGROUND CONTEXT: For correction of severe and rigid scoli-
otic curve, anterior-posterior combined or posterior vertebral column re-
section procedures are used. Anterior release is a burden for patient
with already compromised pulmonary functions and posterior column re-
section carries a high risk of neurologic damage as well as massive intra-
operative bleeding. Therefore, authors developed a new technique, which
avoids the both.
PURPOSE: It is a prospective study of 13 neuromuscular scoliosis pa-
tients with severe and rigid curves to determine the effectiveness and
amount of correction with this technique without anterior release.
STUDY DESIGN/ SETTING: Thirteen neuromuscular scoliosis patients
(7 CP, 2 DMD and 4 SMA) who had rigid curve more than 100 degrees
were selected for the study prospectively. All patients were operated with
posterior-only approach using pedicle screw construct.
PATIENT SAMPLE: There were seven males and six females with an av-
erage age of 21 years (range, 13–32 years). There were nine thoraco-lum-
bar curves, three lumbar curves and one thoracic curve. Average
preoperative Cobb’s angle in coronal plane was 118.2� (range, 100�-150�) with flexibility of 20.3% (average 24.1�, range 10�-36�) on bending
radiograms.
OUTCOME MEASURES: The correction in Cobb’s angle, pelvic obliq-
uity and apical axial derotation were compared with paired t-test. For fur-
ther evaluation, we divided our patients in two groups: spastic and
paralytic groups and we evaluated our results between these two groups
using unpaired t-test. P value of less than 0.05 was considered significant
for all the statistical calculations.
METHODS: To achieve desired correction, multilevel vertebral osteoto-
mies were executed at three to five levels (apex and one or two level above
and below the apex) through laminectomy sites connecting from concave
to convex side. Once osteotomies were finished, repeated corrective ma-
nipulation was applied over temporary short segment fixation, above and
below the apex, on convex side. On concave side, the rod was fixed with
screws with manipulation followed by derotation maneuver. Finally, short
segment fixation removed and rod-screw construct fixed on convex side,
which was followed by posterior fusion. Intraoperative MEP monitoring
was applied for all patients.
RESULTS: Average follow-up was 25 months. Average preoperative
Cobb’s angle, pelvic obliquity and apical rotation were 118.2�, 16.7�
and 57� respectively. Average postoperative Cobb’s angle, pelvic obliquity
and apical rotation were 48.8�, 8� and 43� respectively showing 59.4%,
46.1% and 24.5% correction, which were significant statistically. Average
number of osteotomy level was 4.2 and average blood loss was 33566884
milliliters. Mean operation time was 330646 minutes and none of the pa-
tient required postoperative ventilator support. None of the patient dis-
played any signs of neurological or vascular injuries during or after the
operation.
CONCLUSIONS: We recommend multiple posterior vertebral osteoto-
mies for severe and rigid scoliosis because of following advantages: 1) it
provides release of anterior column under direct vision of cord; 2) it facil-
itates creep relaxation to the anterior as well as posterior structures and 3)
prevents need of anterior procedure, and reduces massive bleeding and
chances of neurological damage.
FDA DEVICE/DRUG STATUS: This abstract does not discuss or include
any applicable devices or drugs.
doi:10.1016/j.spinee.2008.06.258
P17. Acute Fracture of the End or Adjacent Level after Posterior
Lumbar Spine Fusion and Instrumentation
Edward Abraham, MD, Neil Manson, MD; Atlantic Health Sciences
Corporation, Saint John, New Brunswick, Canada
BACKGROUND CONTEXT: The incidence of Adjacent Segment
Degeneration after spinal fusion is variable with a third of cases requiring
revision surgery. Acute Adjacent Segment Fracture (AASF) of the end or
adjacent, proximal or distal vertebrae is not well recognized and sparsely
reported on. Associated neurological compromise and instability necessi-
tates urgent major revision surgery and subsequent potential morbidity
in this population.Identifying risk factors to prevent these catastrophies
from taking place is important.
PURPOSE: The purpose of this study was to determine the incidence of
AASF and to identify risk factors associated with its occurrance.
STUDY DESIGN/ SETTING: Acute fracture post spinal fusion was de-
fined as those presenting within 4 months.321 instrumented thoracolumbar
fusions were performed between 2005–07 and 13 cases of AASF were
identified. These patients were analyzed clinically and radiologically to
look at possible risk factors. The clinical presentation and treatment of
AASF was studied. This was a retrospective review of a prospective data
bank in one institution.
PATIENT SAMPLE: 13 cases of AASF were studied over the 2 yr time
period 2005–2007. These were decompression, fusion and instrumentation
surgeries performed at the index operation for spinal stenosis. 1 pt was a 2-
level and 12 were for O2 levels, all surgery performed in the same institu-
tion by the authors.
OUTCOME MEASURES: Patient demographics, fusion levels at index
operation, radiological analysis (sagittal, coronal axes; pre-fracture pedicle
screw instrumentation position, type of fracture), type of revision surgery
necessary and SF-36, ODI evaluations were outcome measures in this
study.
METHODS: 321 instrumented spinal fusions were reviewed between
2005–2007. 13 cases of AASF were identified presenting before 4 mos
post op and are the subject of this study. Type of fracture, neurological pic-
ture, radiological assessments and clinical evaluations were carried out.
Type of revision surgery and response were assessed.Incidence and risk
factors were identified.
RESULTS: The incidence of AASF in this group was 4%(13/321). The
overall incidence of Adjacent Segment Degeneration of all types was
25%, 8% requiring surgery. There were 12 females and 1 male in the
AASF grp, avg age 75, avg no. levels fused:3.5 at the index OR.9/13
had proximal and 5/13 had distal fractures. 2 pts required surgery for re-
peat fractures. 12/13 required surgery to address instability and