(p-43) scintigraphic determinant for tc-99m-mibi parathy-roid imaging

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(P-41) Spiral CT Scanning or HASTE MRU in Acute Calculus Ureteric Obstruction: Pretenders to the Throne! Fintan Regan, MD Johns Hopkins Bayview Medical Center, Balti- more, MD, Brian S. Kuszyk, MD, Mark E. Bohlman, MD, John D. Petronis, MD Purpose: Although IV urography (IVU) has been traditionally used to image the acutely obstructed ureter, other modalities have re- cently been used. The aim of this study is to compare spiral CT to the combination of HASTE MR urography (MRU) with plain ab- dominal radiography (KUB). Materials and Methods: 65 patients with suspected acute calcu- lus ureteric obstruction were evaluated. Perirenal fluid, presence and level of ureteric obstruction and stones were assessed on both techniques. Results: 43/65 patients had proven acute calculus ureteric obstruc- tion. MRU showed perirenal fluid with a sensitivity of 85% (CT- 73%), specificity of 96% (CT-88%), and accuracy of 89% (CT- 78%). A dilated ureter was demonstrated by MRU with a sensitivity of 87% (CT-73%), specificity of 100% (CT-95%), and accuracy of 72% (CT-83%). The combination of fluid and ureteric dilation on MRU showed a sensitivity of 89% (CT-77%), specificity of 94% (CT-85%), and accuracy of 89% (CT-78%). MRU/KUB missed stones (<5ram diameter) in 11 patients with stones shown by CT. Overall, MRU/KUB revealed 3.2 abnormalities per acutely ob- structed ureter compared to 2.2 abnormalities detected by CT in the same patients (P <.005). Conclusion: MRU/KUB can diagnose the presence and level of acute calculus ureteric obstruction with greater accuracy than CT. (P-42) Appearances of Benign Calcifications on Mammogra- phy Alexandra Osorio, MD Temple University Hospital, Philadelphia, PA, Beth A. Scott, DO Purpose: To demonstrate the various appearances of benign calcifi- cations seen on mammography. Materials and Method: Retrospective review of benign calcifi- cations seen on mammography at our institution. Results/Conclusions: Identification of calcifications in mammo- grams is important in the detection of pathology. It is important to recognize them and characterize them, since calcifications may sometimes be the only mammographic sign of cancer. There are several calcifications seen on mammography that are associated with benign disease. Dermal calcium, calcified lipid cysts, secre- tory calcifications, milk of calcium and disappearing calcifica- tions are only some of these findings. The radiologist should be able to recognize these patterns and make management recom- mendations to referring doctors. (P-43) Scintigraphic Determinant for Tc.99m.MIBI Parathy- roid Imaging Sung M. Kim, MD Thomas Jefferson University Hospital, Phila- delphia, PA, Charles M. Intenzo, MD, David Capuzzi, MD, Jef- frey M. Miller, MD Purpose: To determine which scintigraphic, cellular and chemi- cal parameter is the most responsible determinant for detection of parathyroid lesion(s) in Tc-99m methoxyisobutyl-isonitrile (MIBI) parathyroid imaging. Methods and Materials: Dual-phase parathyroid scan was per- formed in 22 patients with hyperparathyroidism. This analysis in- cludes 17 adenomas, 8 hyperplastic leasions and 65 normal par- athyroid glands. Tc-99m-MIBI tracer uptake in initial (IT) and delayed phase (DT) was semiquantitatively calculated. Lesion detectability was correlated with several parameters responsible for hyperparathyroidism; IT, DT, total number of parathyroid cells, each % composition of parathyroid cell types, size of le- sion, serum calcium and parathyroid hormone (PTH) levels. Results: Correlation coefficiencies between tracer uptake and other parameters were as follows: IT (+0.67), DT (+0.55), total number of cell (+0.51), % oxyphilic cell (+0.32), % chief cell (+0.26), size of lesion (+0.22), serum calcium and PTH (0), and % clear cell (-0.21). Conclusion: Initial Tc-MIBI uptake is the most responsible de- terminant for detection of parathyroid adenoma and hyperplasia, whereas % clear cell content in parathyroid lesion showed nega- five correlation. (P-44) Thrombolytic Therapy in the Treatment of Radial Ar- tery Thrombosis due to Indwelling Radial Artery Lines Drew L. Lambert, BS Johns Hopkins Hospital, Baltimore, MD, Jean-Francois Geschwind, MD, David G. Omdal, MD, Scott J. Savader, MD, Sally E. Mitchell, MD Purpose: The purpose of this study was to evaluate the role of urokinase in the treatment of radial artery thrombosis due to arte- rial lines placed in the radial artery. Materials & Methods: The records of five patients who under- went percutaneous catheter-directed thrombolysis ~of thrombosed radial arteries at our institution between 1995-98 were reviewed. The outcome of six high-dose urokinase infusions in these pa- tients was examined. A successful outcome was defined as an- giographic restoration of flow with minimal or no residual thrombus within the radial artery. An antegrade approach was used in four of six cases, with access achieved through the low branchial or radial artery. Results: An angiographically successful outcome was achieved in four of six high-dose urokinase infusions. Significant clinical improvement in ischemic signs and symptoms was noted in all suc- cessful cases. Two infusions yielded no significant change, likely due to advanced disease (late discovery of the ischemic hand) or un- derlying factors such as sepsis. Conclusion: Radial artery thrombosis is a rare and serious com- plication of radial arterial line placement. This study demon- strates the efficacy of high-dose urokinase infusion, with near complete restoration of flow in four of six infusions. It is essen- tial to recognize the presence of hand ischemia as quickly as pos- sible when the patient has an arterial line in place since these pa- tients can improve angiographically and clinically with prompt thrombolytic therapy. (P.45) Comparative Imaging Modalities for CT Cystography L. Kirldand Coilrad, MD University of Chicago, Chicago, IL, Abraham Dachman, MD, Edward J. Kirsh, MD, Glenn Gerber, MD Purpose: To compare the speed and ease of use of CT cystography using various reconstructive techniques for the detection, localiza- tion, measurement, and characterization of urinary bladder masses. Materials and Methods: Four techniques were employed to in- terpret data from 10 patients: conventional two-dimensional (2D) data with 3D problem solving, standardized volume-rendered (VR) and surface-shaded display (SSD) 3D images, and an inter- active 3D stereoscopic system. The images were compared to conventional cystoscopy by a radiologist and a urologist. Results: 22 (100%) of 22 masses detected on conventional cys- toscopy were visualized using the various reconstructive tech- niques. By conventional cystoscopy 5 patients were normal and 5 were abnormal, with 1 to 10 polyps each. Conclusion: The standard 2D data display with 3D problem solving and the interactive 3 D stereoscopic modality as used by the radiologist had a sensitivity and specificity of 100%. The in- teractive 3D stereoscopic modality as used by the urologist and 634

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Page 1: (P-43) Scintigraphic determinant for Tc-99m-MIBI parathy-roid imaging

(P-41) Spiral CT Scanning or HASTE MRU in Acute Calculus Ureter ic Obstruction: Pretenders to the Throne! Fintan Regan, M D Johns Hopkins Bayview Medical Center, Balti- more, MD, Brian S. Kuszyk, MD, Mark E. Bohlman, MD, John D. Petronis, M D

Purpose : Al though IV urography (IVU) has been traditionally used to image the acutely obstructed ureter, other modalit ies have re- cently been used. The aim of this study is to compare spiral CT to the combinat ion of H A S T E M R urography (MRU) with plain ab- dominal radiography (KUB).

M a t e r i a l s a n d M e t h o d s : 65 pat ients with suspec ted acute calcu- lus ureteric obst ruct ion were evaluated. Perirenal fluid, p resence and level o f ureteric obst ruct ion and s tones were a s sessed on both techniques .

Resul t s : 43/65 patients had proven acute calculus ureteric obstruc- tion. M R U showed perirenal fluid with a sensitivity of 85% (CT- 73%), specificity of 96% (CT-88%), and accuracy of 89% (CT- 78%). A dilated ureter was demonstra ted by M R U with a sensitivity of 87% (CT-73%), specificity of 100% (CT-95%), and accuracy o f 72% (CT-83%). The combinat ion of fluid and ureteric dilation on M R U showed a sensitivity of 89% (CT-77%), specificity o f 94% (CT-85%), and accuracy of 89% (CT-78%). M R U / K U B missed stones (<5ram diameter) in 11 patients with stones shown by CT. Overall, M R U / K U B revealed 3.2 abnormalit ies per acutely ob- structed ureter compared to 2.2 abnormalit ies detected by CT in the same patients (P <.005).

Conclus ion : M R U / K U B can diagnose the presence and level o f acute calculus ureteric obstruction with greater accuracy than CT.

(P-42) Appearances of Benign Calci f icat ions on Mammogra- phy Alexandra Osorio, M D Temple University Hospital, Philadelphia, PA, Beth A. Scott, DO

Purpose : To demonstrate the various appearances o f benign calcifi- cations seen on mammography .

M a t e r i a l s a n d M e t h o d : Ret rospect ive review of ben ign calcifi- cat ions seen on m a m m o g r a p h y at our insti tution.

R e s u l t s / C o n c l u s i o n s : Identif icat ion of calcif icat ions in m a m m o - g rams is impor tan t in the detect ion of pathology. It is impor tant to recognize them and character ize them, s ince calcif icat ions m a y some t imes be the only m a m m o g r a p h i c s ign of cancer. There are several calcif icat ions seen on m a m m o g r a p h y that are associa ted with ben ign disease. Dermal ca lc ium, calcif ied lipid cysts , secre- tory calcif icat ions, mi lk o f ca lc ium and disappear ing calcifica- t ions are only some of these f indings. The radiologis t should be able to recognize these pat terns and make m a n a g e m e n t r ecom- menda t ions to referr ing doctors.

(P-43) Scint igraphic Determinant for Tc .99m.MIBI Parathy- roid Imaging Sung M. Kim, M D Thomas Jefferson University Hospital, Phila- delphia, PA, Char les M. Intenzo, MD, David Capuzzi , MD, Jef- frey M. Miller, M D

P u r p o s e : To de te rmine wh ich scint igraphic, cellular and chemi- cal parameter is the mos t respons ib le de te rminant for detect ion of parathyroid lesion(s) in T c - 9 9 m methoxyisobuty l - i soni t r i l e (MIBI) parathyroid imaging .

M e t h o d s a n d M a t e r i a l s : Dua l -phase para thyroid scan was per- fo rmed in 22 patients with hyperpara thyro id i sm. This analys is in- cludes 17 adenomas , 8 hyperplas t ic leasions and 65 no rma l par- athyroid glands. T c - 9 9 m - M I B I tracer uptake in initial (IT) and delayed phase (DT) was semiquant i ta t ive ly calculated. Les ion detectabil i ty was correlated with several parameters respons ib le

for hyperpara thyro id i sm; IT, DT, total n u m b e r o f parathyroid cells, each % compos i t ion o f parathyroid cell types, size o f le- sion, s e rum ca lc ium and para thyroid ho rmone (PTH) levels.

Resu l t s : Correlat ion coeff ic iencies be tween tracer uptake and other parameters were as fol lows: IT (+0.67), D T (+0.55), total n u m b e r o f cell (+0.51), % oxyphi l ic cell (+0.32), % chief cell (+0.26), size o f lesion (+0.22), s e rum ca lc ium and PTH (0), and % clear cell ( -0 .21) .

C o n c l u s i o n : Initial Tc -MIBI uptake is the mos t responsib le de- t e rminant for detect ion o f parathyroid adenoma and hyperplas ia , whereas % clear cell content in parathyroid lesion showed nega- five correlation.

(P -44) Thrombolyt ic Therapy in the Treatment of Radial Ar- tery Thrombosis due to Indwel l ing Radial Artery Lines Drew L. Lamber t , BS Johns Hopkins Hospital, Baltimore, MD, Jean-Francois Geschwind , MD, Dav id G. Omdal , MD, Scott J. Savader, MD, Sally E. Mitchel l , M D

P u r p o s e : The purpose of this s tudy was to evaluate the role o f urokinase in the t rea tment o f radial artery th rombos is due to arte- rial l ines placed in the radial artery.

M a t e r i a l s & M e t h o d s : The records o f five pat ients who under- went pe rcu taneous catheter-directed th rombolys i s ~of th rombosed radial arteries at our inst i tut ion be tween 1995-98 were reviewed. The ou tcome of six h igh-dose urokinase infus ions in these pa- t ients was examined . A success fu l ou tcome was def ined as an- g iographic restorat ion o f f low with min ima l or no residual t h rombus within the radial artery. An antegrade approach was used in four o f six cases, with access ach ieved through the low branchial or radial artery.

Resu l t s : An angiographica l ly success fu l ou tcome was achieved in four o f six h igh-dose urokinase infus ions . Signif icant clinical i m p r o v e m e n t in ischemic signs and symptoms was noted in all suc- cessful cases. Two infusions yielded no significant change, likely due to advanced disease (late discovery o f the ischemic hand) or un- derlying factors such as sepsis.

C o n c l u s i o n : Radial artery th rombos is is a rare and serious co m - pl icat ion o f radial arterial l ine p lacement . This s tudy demon- strates the eff icacy o f h igh-dose urokinase infusion, with near comple te restorat ion o f f low in four o f six infusions . It is essen- tial to recognize the presence of hand i schemia as quickly as pos- sible when the patient has an arterial l ine in place s ince these pa- t ients can improve angiographica l ly and clinically with p rompt thrombolyt ic therapy.

(P .45 ) Comparat ive Imaging Modal i t ies for CT Cystography L. Kirldand Coilrad, M D University of Chicago, Chicago, IL, Abraham Dachman, MD, Edward J. Kirsh, MD, Glenn Gerber, M D

Purpose : To compare the speed and ease of use of CT cystography using various reconstructive techniques for the detection, localiza- tion, measurement , and characterization of urinary bladder masses .

M a t e r i a l s a n d M e t h o d s : Four techniques were employed to in- terpret data f rom 10 patients: convent iona l two-d imens iona l (2D) data with 3D prob lem solving, s tandardized vo lume- rende red (VR) and sur face-shaded display (SSD) 3D images , and an inter- active 3D stereoscopic sys tem. The images were compared to convent iona l cys toscopy by a radiologis t and a urologist .

Resu l t s : 22 (100%) of 22 m a s s e s detected on convent iona l cys- toscopy were v isua l ized us ing the var ious reconst ruc t ive tech- niques. By convent iona l cys toscopy 5 patients were no rma l and 5 were abnormal , with 1 to 10 polyps each.

C o n c l u s i o n : The s tandard 2D data d isplay with 3D prob lem solv ing and the interact ive 3 D s tereoscopic modal i ty as used by the radiologis t had a sensi t iv i ty and specif ici ty o f 100%. The in- teractive 3D stereoscopic modal i ty as used by the urologis t and

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