outline
DESCRIPTION
Introduction Spiral Cone-beam CT Interior Tomography Multi-scale CT Work in Progress. Outline. Integrated Biomedical Research Program 3 Medical Schools 1 Vet-Med College 10 Institutes/Centers 51 Faculty (17 Primary). Virginia Tech. Established in 1872 - PowerPoint PPT PresentationTRANSCRIPT
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Outline
• Introduction• Spiral Cone-beam CT• Interior Tomography• Multi-scale CT• Work in Progress
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Integrated Biomedical Research Program
3 Medical Schools
1 Vet-Med College
10 Institutes/Centers
51 Faculty (17 Primary)
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Virginia Tech
• Established in 1872• Ranked 25th for College of Engineering• Ranked 12th in Patents• Ranked 8th in Licenses to Start-ups• Best multi-scale CT facility
3
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Wake Forest University
• Medical School Established in 1902• Ranked 30th among National Universities • Ranked 32th in NIH Funding• Ranked 1st in Regenerative Medicine (WFIRM)
4
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Biomedical Imaging
Nuclear Imaging CT/X-Ray MRIBioluminescence &
Fluorescence
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Computed
Tomography
Bioluminescence
Imaging
Optical
Tomography
Bioluminescent
Views
Individualized
Volume
Shape
Model
Optical
Model
3D
Mapping
Wang G, et al.: In vivo mouse studies with bioluminescence tomography. Optics Express
14:7801-7809, 2006
Bioluminescence Tomography (2002)
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Recently Awarded BRP (“973”)
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Outline
• Introduction• Spiral Cone-beam CT• Interior Tomography• Multi-scale CT• Work in Progress
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Scanning for Faster Speed
Spiral into Modern CT Era
Ray Sum
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Spiral Fan-beam CT (1983)
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Ray A
1D Detector Array
x
y
zz
Interpolation to Planar Data
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Spiral Cone-beam CT (1991)
Wang, G, Lin, TH, Cheng PC, Shinozaki DM, Kim, HG: Scanning cone-beam reconstruction algorithms for x-ray microtomography. Proc. SPIE Vol.
1556, p. 99-112, July 1991 (Scanning Microscopy Instrumentation, Gordon S. Kino; Ed.)
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Multiple Implications
To solve the long-object problem, a first level of improvement with respect to the 2D FBP
algorithms was obtained by backprojecting the data in 3D, along the actual measurement rays.
The prototype of this approach is the algorithm of Wang et al.
Defrise, Noo, Kudo: A solution to the long-object problem in helical cone-beam tomography. Phys. Med. Biol. 45:623-643, 2000
Many advances in CB reconstruction have been made recently thanks to the quest for an
attractive reconstruction method in helical CB tomography.
Pack, Noo, Clackdoyle: Cone-beam reconstruction using the backprojection of locally filtered projections. IEEE Trans. Medical Imaging 24:1-16, 2005
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Seeking Exact Solution (1997)
“Cone-beam spiral CT seems an ideal imaging mode. It is desirable and possible that
an exact cone-beam reconstruction algorithm be designed that takes longitudinally
truncated cone-beam data and is computationally efficient.”
Wang G, Cheng PC, Vannier MW: Spiral CT - Current status and future directions. Proc. SPIE 3149 203–12, 1997
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Katsevich Formula (2002)
dsdxsqyDqsyx
xf sqfxIPI
sin1|)),,(),((
|)(|1
21)(
2
0)(
),(),(),( xsuxsxse ),(sin),(cos),,( xsexsxs
)( 0sy
e
),( xsu
),( 0 xs
)( 1sy
)( 2sy
)(xf
Detector
Plate
SourceObject
Pi-Line
Katsevich A: A general scheme for constructing inversion algorithms for cone beam CT. Int'l J. of Math. and Math. Sci. 21:1305-1321, 2003
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h-index=30
Annually, ~100M CT scans are performed in USA alone
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Dual-source CT (2003)
Dual-source In vivo Micro-CT scanner
Designed by BIR, Hoffman, Wang
Built by BIR in 2003
Bioluminescence tomography prototype
Designed by Wang, Hoffman, McLennan
Built by us & UI Med. Inst. Facility in 2003
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Outline
• Introduction• Spiral Cone-beam CT• Interior Tomography• Multi-scale CT• Work in Progress
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Interior Tomography (2007)
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Sparsity-based Interior Recon
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Inner Vision with Local Data
t
Sinogram
X-rays
Projectio
n:
Linear in
tegral
s
ty
x
Measurement
Reconstruction
Object),( yxf
),( tP
X X
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Ultrafast Temporal Resolution
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From Scanning to Roaming
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Extension to Other Modalities
Ge Wang, Hengyong Yu
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Limited Angle Interior Tomography
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Interior CT Patent
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Outline
• Introduction• Spiral Cone-beam CT• Interior Tomography• Multi-scale CT• Work in Progress
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SBES Advanced Multi-scale CT Facility
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Nano-CT Momentum
Andrew G. Peele et al.: High Resolution X-ray phase tomography. Proc. SPIE CT Conference, 2010
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Interior Nano-CT
X-ray Beam Central Stop
Condense Lens
Sample
Zone
Plate
Phase Ring
Detector Plane
ROI
Sample Stage
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Potential for Study on Earliest Life
Hagadorn JW, et al. (2006) Cellular and subcellular structure of Neoproterozoic embryos.
Science 314:291–294
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Smaller Scales?
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Outline
• Introduction• Spiral Cone-beam CT• Interior Tomography• Multi-scale CT• Work in Progress
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Multi-parameter CT
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Wang G, Cong W, Shen H, Zou Y: Varying Collimation for Dark-Field Extraction. International Journal of
Biomedical Imaging. 2009, Article ID 847537, 2010
Dark-field Tomography
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Multi-energy CT
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Acknowledgement
Important collaborators include, but not limited to, Drs. E. W. Bai, J. A. Brink, Z. Q. Chen, P. C. Cheng, W. X. Cong, M. Furth, W. M. Han, M. Jiang, A. Katsevich, Y. Li, L. Li, H. O. Shen, D. M. Shinozaki, D. L. Snyder, S. Soker, M. W. Vannier, S. Wang, Y. B. Wen, C. Wyatt, Y. Xu, J. S. Yang, Y. B. Ye, H. Y. Yu, J. Zhao, T. G. Zhuang, and Y Zou.
This work is partially supported by multiple NSF, NIH and industrial grants.
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Thank You for Invitation!