osteonecrosis jaw
TRANSCRIPT
Current Definition of ONJ
Clinical Features• Exposed bone in maxillofacial
area that occurs in association with dental surgery (approximately 75% of the cases) or occurs spontaneously (usually occurs in areas prone to trauma, ie. tori), with no evidence of healing1
• Pain can or cannot be present
Diagnosis of ONJ• No evidence of healing after
8 weeks of appropriate evaluation and dental care2
• No evidence of metastatic disease in the jaw or osteoradionecrosis
1. Ruggiero S, et al. J Oncol Pract. 2006;2:7-142. Khosla S, et al. J Bone Miner Res. 2007;22:1479-1491.
•Ostenecrosis of the jaw after anticatabolic treatment
Epidemiology of osteonecrosis of the jaw
Etiopathogenesis of ONJ not known
ONJ in patients with osteoporosissteoporosis::
0,0028% - 0,0053%~ 1:19.000 - 1:36.000
No specific recommendations.
ONJ in BP-treated patients with cancer : 1 – 10% = ~ 1:10 – 1:100
ONJ: Are There any Concerns in
Clinical Practice?
Bisphosphonate-associated ONJ Cases in Osteoporosis
• ONJ has been reported in approx. 5% of patients with cancer receiving high-dose IV bisphosphonates1
• The risk of bisphosphonate-related ONJ was estimated to be approx. 1 in < 100,000 patient-treatment years2
• Review of 44 case reports/series in 2008 describing 481 patients with bisphosphonate-related ONJ found3:
– ONJ more common in patients receiving IV bisphosphonates (453 patients, 94.2%) vs. oral bisphosphonates (28 patients, 5.8%)
– Over 90% of patients who developed ONJ had cancer– Approx. 31% of patients had prior use of glucocorticoids– 68.8% cases occur after surgical or invasive dental procedures– 93 patients (20.7%) developed ONJ spontaneously
• More recently, ONJ has been reported in cancer patients treated with denosumab1
IV = intravenous1. Reid IR, Cornish J. Nat Rev Rheumatol. 2011;doi:10.1038/nrrheum.2011.181. 2. Burr DB, et a. J Musculoskelet Neuronal Interact. 2007;7:354–355. 3. King AE, et al. Pharmacotherapy. 2008;28:667–77.
Atypical femur fractures: Are There Any in Clinical
Studies?
Main Features
• Located along the femur from just distal to the lesser trochanter to just proximal to the supracondular flare
• Associated with no or minimal trauma• Transverse or short oblique configuration• Non-comminuted• Complete fractures must extend through both cortices while incomplete fractures
involve only the lateral cortex
Minor Features
• Periosteal reaction of the lateral cortex (“beaking”)
• Increase cortical thickness• Prodromal pain• Bilateral fractures and symptoms
• Delayed healing• Comorbid conditions (e.g. vitamin D
deficiency, rheumatoid arthritis)• Use of pharmaceutical agents (e.g.
bisphosphonates, glucocorticoids)
ASBMR Task Force on Atypical Femur Fractures: Provisional Case Definition
ASBMR = American Society of Bone and Mineral Research.Shane E et al. J Bone Miner Res. 2010.
Subtrochanteric Fractures of the Femur
Watts NB et al. J Clin Endocrinol Metab 2010;95:1555–1565.
Case Study
Report: Normal Report: Thickening of the cortex of shaft of left femur;
slightly more than on the film in 2008 –
stress fracture?
September 2008 May 2009 June 2009
CT femur
Epidemiological Data on Atypical Femur Fractures
• Atypical fractures can also be seen (with lower frequency) in non-bisphosphonate users
• Current opinion is that atypical fractures are “stress” fractures that may appear earlier on bone scan or CT scan – Reasons are unknown and may propagate in a small subset
of patients
ASBMR = American Society of Bone Mineral Research; CT = computerized tomography.Pazianas M, Abrahamsen B. Bone 2011. 49:103–110.
The Absolute Risk of Atypical Fracture among Bisphosphonate Users is Small
Number, n
Patients Who Would
Need to Be Treated*
Events per 1000 Patients
Treated for 3 Years
Type of fracture
Any fracture
Any nonvertebral fracture
Hip fracture only
Vertebral fracture
(morphometric)
–
35
90
14
100
29
11
71
Hypothetical relative risk of subtrochanteric or diaphyseal femur fracture
2.0 1449 0.7
*Estimated numbers of patients who would need to be treated with either zoledronic acid or alendronate in order to prevent one fracture were derived from fracture rates, as compared with placebo in the FIT and HORIZON-PFT;†The number of events per 1000 patients treated for 3 years refers to fractures that would be prevented by bisphosphonate treatment.Black DM, et al. N Engl J Med 2010;362:1761–1771.
Case Reports/Case Series Involving ‘Atypical’ Fractures of the Femur
• A recent systematic review of the literature up to 2010 that identified 141 atypical femoral fractures following bisphosphonate therapy showed:*– The bisphosphonate regimen preceding fracture was:
• Alendronate, n = 119• Risedronate, n = 7• Pamidronate, n = 3• Sequential therapy†, n = 7• Unspecified, n = 5
– 53/120 patients (44%) suffered bilateral fractures– Prodromal pain was common (56/88; 64%)
*Bisphosphonate administered at a dosing regimen used for the prevention or treatment of osteoporosis†Alendronate/ibandronate, n=4; alendronate/risedronate, n=2; pamidronate/risedronate, n=1.Giusti A, et al. Bone 2010;47:169–180.
Summary• Post-hoc analysis of baseline characteristics of patients in the
HORIZON-RFT study who suffered a low-trauma hip fracture showed that incident subtrochanteric fractures:– Are not uncommon – Do occur in bisphosphonate-naïve patients
• Secondary analysis of 14,195 patients from the FIT, FLEX and HORIZON-PFT trials showed: – No significant increase in risk of subtrochanteric or
diaphyseal femur fracture after bisphosphonate treatment• The pathophysiology of ‘atypical’ subtrochanteric or
diaphyseal fractures is unclear