organic mental disorders ii: dementias martin brunovsky, md, phd prague psychiatric center 3 rd...
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Organic mental disorders II: dementias
Martin Brunovsky, MD, PhD
Prague Psychiatric Center
3rd Faculty of Medicine Charles University
Dpt. of Neurology, Faculty Hospital Bulovka
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Dementia
a syndrome which is acquired and characterized by multiple impairments in cognitive functions without impairment in
consciousness
• Memory impairment, plus– Impairment in at least one other domain: language, visuospatial
skill, executive abilities, and emotion
- Representing decline- Interfering with function- Not better accounted for by a number of other conditions DSM-IV-TR; APA 2000
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Definition of dementia• from Latin demens, dement =„senseless“ or de + mens = „deprived of mind“• not a specific disorder or disease – rather an acquired syndrome (group of
symptoms) characterized by loss of function in multiple cognitive domains.
DSM-IV diagnosis of Dementia: An acquired syndrome characterized by:
• MEMORY IMPAIRMENT (short-term ) and at least one of the following:
• Aphasia - language memory impair.
• Apraxia - motor memory impairments
• Agnosia - sensory memory impair.
• Executive dysfunction/ abstract think.
• Severe enough to cause impairment in social and occupational functioning
• Cognitive decline represents decline from previous functioning
• Deficits cannot be accounted for by delirium, other CNS condition, systemic condition, or substance-induced…
ICD-10 diagnosis of Dementia:• A decline in memory to an extent that it
interferes with everyday activities, or makes independent living either difficult or impossible.
• A decline in thinking, planning and organizing day-to-day things, again to the above extent.
• Initially, preserved awareness of the environ-ment, including orientation in space and time.
• A decline in emotional control, motivation, or a change in social behaviour, as shown in one or more of the following: emotional lability, irritability, apathy or coarsening of social behaviour, as in eating, dressing and interacting with others.
American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, D.C, American Psychiatric Association, 1994
World Health Organization: The ICD-10 Classification of Mental and Behavioural Disorders. Clinical Descriptions and Diagnostic Guidelines, Geneva, World Health Organization, 1992.
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Every edition of DSM or ICD requires that patients with dementia have a deficit in memory...
But memory loss is often not an early or cardinal symptom in patients with: ...vascular dementia, frontotemporal dementia, or Parkinson-related dementias...
e.g. the Merck Manual of Geriatrics' definition of dementia:
„A deterioration of intellectual function and other cognitive skills, leading to a decline in the ability to perform activities of daily living…“
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A Classification System for the Types of Dementia
Dementing disorders can be classified in many different ways. These classification schemes attempt to group disorders that have particular features in common, such as whether they are progressive or what parts of the brain are affected.
• Cortical dementia • Subcortical dementia • Progressive dementia • Primary dementia • Secondary dementia
Some types of dementia fit into more than one of these classifications. For example, Alzheimer's disease is considered a progressive, primary, and cortical dementia.
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CORTICAL DEMENTIA refers to dementia in which brain damage primarily affects the brain's cortex, or outer layer. Cortical dementias tend to cause problems with memory, language, thinking, and social behavior.
SUBCORTICAL DEMENTIAis dementia that affects parts of the brain below the cortex. This dementia type tends to cause changes in emotions and movement in addition to problems with memory. One example of this dementia type is Binswanger's disease.
PROGRESSIVE DEMENTIAis dementia that gets worse over time, gradually interfering with more and more cognitive abilities. Lewy body dementia is an example of a progressive dementia.
PRIMARY DEMENTIA is dementia (such as Alzheimer's disease) that does not result from any other disease.
SECONDARY DEMENTIAis dementia that occurs as a result of a physical disease or injury.
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Treatable Versus Untreatable DementiaAnother classification system that is used for dementia separates the causes of dementia into treatable or untreatable.
Treatable Dementia• About 10 percent of conditions that cause dementia
are treatable!!! • With treatment, the dementia can either be reversed
or at least halted. Examples of conditions that cause treatable cases of dementia include: • Normal pressure hydrocephalus • A brain tumor or brain cancer • Hypothyroidism • Vitamin B12 deficiency • Neurosyphilis• Reactions to medications • Poisoning
• a condition of pathologically enlarged ventricular size with normal opening pressures on lumbar puncture
• triad of dementia, gait disturbance, and urinary incontinence
• reversible by the placement of a ventriculoperitoneal shunt
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Non-Treatable Dementia Although a number of diseases can cause dementia, Alzheimer's disease is by far the most common. More than one-half of all dementia cases are caused by Alzheimer's disease. The second most common cause of dementia is multi-infarct dementia, which is a type of vascular dementia.
Alzheimer's disease Multi-infarct dementia Lewy body dementia Binswanger's disease Frontotemporal dementia Corticobasal degeneration HIV-associated dementia Other infections within the brain, such as Creutzfeldt-Jakob
disease Huntington's disease and other rare hereditary dementias Head trauma, such as dementia pugilistica (also known as boxer's
syndrome).
Other conditions that can cause dementia or dementia-like symptoms include:
Parkinson's disease or multiple sclerosis (MS) Heart and lung problems Anoxia or hypoxia (conditions in which the brain's oxygen supply
is either reduced or cut off entirely).
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Major Etiologies of Dementia
Alzheimer’s diseaseVascular dementia Dementia with Lewy
Bodies Frontotemporal Dementia
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INCIDENCE OF DEMENTIA TYPES
Alzheimer's disease60%
AD in Parkinson's disease
7%
Vascular, mixed and rare15%
Frontotemporal8%
Lewy body dementia10%
1/3 - 2/3 AD VASCULAR PATHOLOGY PRESENT
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The Continuum of Vascular Dementia and Alzheimer’s Disease
VaDAD
Mixed AD + Cerebrovasular
Disease
Infarcts, white matter lesions, vascular risk
factors
Post-stroke dementiaAmyloid plaques and neurofibrillary tangles
• Pure dementia is not common
• 77 % of vascular dem. also has AD
• 66% LBD also has AD
• 50% AD has other pathology
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Differential Diagnosis
1. Alzheimer Disease (pure ~40%, + mixed~70%)
2. Vascular Disease, MID (5-20%)
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Differential Diagnosis: Top Ten (commonly used mnemonic device: AVDEMENTIA)
1. Alzheimer Disease (pure ~40%, + mixed~70%)2. Vascular Disease, MID (5-20%)3. Drugs, Depression, Delirium4. Ethanol (5-15%)5. Medical / Metabolic Systems6. Endocrine (thyroid, diabetes), Ears, Eyes, Environ.7. Neurologic (other primary degenerations, etc.)8. Tumor, Toxin, Trauma9. Infection, Idiopathic, Immunologic10. Amnesia, Autoimmune, Apnea, AAMI
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Differential Diagnosis: Top Ten (commonly used mnemonic device: AVDEMENTIA)
1. Alzheimer Disease (pure ~40%, + mixed~70%)2. Vascular Disease, MID (5-20%)
3. Drugs, Depression, Delirium4. Ethanol (5-15%)5. Medical / Metabolic Systems6. Endocrine (thyroid, diabetes), Ears, Eyes, Environ.7. Neurologic (other primary degenerations, etc.)8. Tumor, Toxin, Trauma9. Infection, Idiopathic, Immunologic10. Amnesia, Autoimmune, Apnea, AAMI
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Alzheimer`s disease
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ALOYSUS "ALOIS" ALZHEIMER(14 June 1864 - 19 Dec 1915)
• German psychiatrist and neuropathologist.
• In 1901, Alzheimer studied a patient in the Frankfurt asylum who had behavior disorder including disorder of short-term memory…
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AUGUSTE DETER
• In the following years this patient became Alzheimer‘s obsession.
• In April 1906, Mrs. D. died and Alzheimer had sent the patient records and the brain to Münich where he was working at Kraepelin's lab.
• Together with two Italian physicians, he would use the staining techniques to identify amyloid plaques and neurofibrillary tangles.
A speech given on 3 November 1906 would be the first time the pathology and the clinical symptoms of presenile dementia would be presented together
Mrs. Auguste Deter 51-year-old patient
Alzheimer A. Ubereine eigenartige Erkrankung der Hirnrinde. Allgemeine Zeitschrift fur Psychiatrie und Psychisch-Gerichtliche Medizin 1907; 64: 146–148.
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DSM-IV DIAGNOSTIC CRITERIA FOR ALZHEIMER'S DISEASE:
Development of cognitive deficits manifested by bothimpaired memory (mainly short-term memory)aphasia, apraxia, agnosia, disturbed executive function
Significantly impaired social/occupational function and activities of daily living
Gradual onset, continuing declineNot due to CNS or other physical conditions (e.g., Parkinson’s, delirium)Not due to an Axis I disorder (e.g., schizophrenia)
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Alzheimer`s disease
Characteristic pathological hallmarks:
B) Microscopic: Tau protein degeneration production of
neurofibrillary tangles (intracelular)
Production of beta-amyloid plaques, (extracelular)
A) MacroscopicBrain atrophy (temporoparietal)
C) dysfunction in the neuromediation systems mainly cholinergic system
(ncl. basalis Meynerti, septal nucl.)
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Alzheimer’s disease
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Chromosome 14(presenilin 1)
Chromosome 1(presenilin 2)
40-42 Amino Acid
Apolipoprotein E4 (41-47% in AD, 16% in healthy controls)
Chromosome 19 (gene for apolipoprotein E)
Activation of microglia, astrocytes, complement, production of membr. porus, vasoconstr.
Production of cytokines and O2
Peroxidation of lipids, Oxidative stress
1) Increased excitotoxicity (Glutamate --- NMDA recept.)
2) Impairment of Ca2+ homeostasis
3) Disturbance of glucose metabolism
Activation of phosphatases, phospholipases
Abnormal phosphorylation of Tau proteins
Production of amyloid plaques
Production of neurofibrillary tangles
„sterile“ inflammation
Neuronal death(mainly cholinergic neurons)
↓AchAmyloid precursor protein Chromosome 21
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Disease Progression in Alzheimer’s Disease
0 1 2 3 4 5 6 7 8 9
Years from diagnosis
Cognitive ability
Functional ability
Behavioral problems
Caregiver time
0%
100%
Change indisease
progression
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Clinical Progression of AD and MCIC
ognit
ive f
unct
ion
• Forgetfulness• Repetitive
questions• Daily function
mildly impaired• Progression of
cognitive deficits• Word-finding
difficulties• Supervision required • Agitation
• Altered sleep patterns
• Total dependence: dressing, feeding, bathing
MCIMMSE 26–30 Mild AD
MMSE 20–25
Moderate AD
MMSE 10–19
Severe ADMMSE 0–9
• Mild subjective/objective memory loss
• Normal function
10 y0 yTime (y)
Time?
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Feldman H, GraconS. In: Clinical Diagnosis and Management of Alzheimer’s Disease. 1996:239-253.
The Progress of Alzheimer’s DiseaseThe Progress of Alzheimer’s Disease
0
5
10
15
20
25
30
0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 5 5.5 6 6.5 7 7.5 8 8.5 9
Years
MM
SE s
core
Early diagnosis Mild-moderate Severe
Cognitive symptoms
Loss of ADL
Behavioral problems
Nursing home placement
Death
Ashford et al., 1995
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LATENT = No Cognitive Impairment MCI = Mild Cognitive ImpairmentSCI = Subjective Cognitive Impairment AD = Alzheimer’s dementia
Birth 10 20 30 40 50 60 70 80 90 100
Years
Dendritic & celldeath
“LATENT” SCI MCI AD
Hypometabolism in “AD-vulnerable” regions medial-temporal lobe atrophy elevated CSF tau/Aβ, isoprostanes
Hypometabolism in “AD-vulnerable” regions medial-temporal lobe atrophy elevated CSF tau/Aβ, isoprostanes
Evolution in the pathogenesis of ADEvolution in the pathogenesis of AD
Aggregation and misfolding of Aβ
followed by plaques and tangles
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AD Progression
Abnormal
Normal TimePresymptomatic eMCI LMCI Dementia
CSF Aβ42
Amyloid imagingFDG-PETMRI hippocampal volumeCSF TauCognitive performanceFunction (ADL)
FDG-PET
MRI hippocampal volume
CSF Aβ42
Amyloid imaging
Cognitive performance
Function (ADL)
CSF Tau
Aisen PS, et al. Alzheimers Dement. 2010. In press.
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Goals of Therapy in Alzheimer’s Disease
Time
Fu
nc
tio
nal
Ab
ility
Slowing of diseaseprogressionTreatment
Symptomaticbenefit
Maintenance of function
Functional restoration
Progression
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Current Therapeutic Options for AD Are Symptomatic
• Approved pharmaceutical treatments for AD (neurotransmitter-based)– Cholinesterase inhibitors (donepezil, rivastigmine, galantamin)– N-methyl-D-aspartate (NMDA) receptor antagonists (memantin)
• Nonpharmacologic– Behavioral and social interventions– Physical and cognitive training– Counselling and support
• There are currently no pharmacologic treatments indicated for predementia AD– Diagnostic criteria are emerging
Waldemar G, et al. Eur J Neurol. 2007;14:e1-e26; Dubois B, et al. Lancet Neurol. 2007;6:734-746.
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TREATMENT & MANAGEMENT:
Primary goals: To enhance quality of life Maximize functional performance by
improving Cognition Mood Behavior
Pharmacologic Cholinesterase inhibitors (donepezil,
rivastigmin, galantamin) NMDA receptor blockers (Memantine)
Non-pharmacologic Driving Advanced Directives and Durable Power
of Attorney Caregiver Social and Community
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Alzheimer disease - History of Treatment
1950 1960 1970 1980 1990 2000 2010
Cholinesterase inhibitors
NMDA antagonist
Abeta sequenced
PS1 mutation
PS2 mutation
ACh loss described
donepezil
Rivastigmine patch
tacrine
memantine
rivastigmine
galantamine
APP (Swedish)
APP (London)
ApoE4
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Acetylcholinesterase Inhibitors (AChEI)
DONEPEZIL (Aricept): 1996 Delay nursing home placement and progression 5mg q d (start) to 10mg q d
RIVASTIGMINE (Exelon): 2000 Global functioning and ADL preservation Start at 1.5mg bid to max 6mg bid, (patches:
start 4.6mg/24h increase to 9.5mg/24h) Rivastigmine approved also for Parkinson Disease
with Dementia (PDD) GALANTAMINE (Reminyl /Razadyne)
(2001/2005) Slowing progression 4mg bid to max 12 mg bid Extended release version: 8mg/day, 16mg/day, 24
mg/day
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donepezil (Aricept) (5-10mg/day)
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rivastigmin (Exelon) (9-12mg/day)
now also as transdermal patch
4.6mg/24h or 9.5mg/24h
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galantamin (Reminyl/Razadyne) (16-24mg/day)
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NMDA antagonists
MEMANTINE (Ebixa ; Namenda) Indicated for moderate to severe
dementia Friendly side-effect profile Start at 5mg daily, target dose:
20mg/day Studies suggest added benefit when
used with CIs Often used with those intolerant to
ChEIs Debate on clinical impact/timing with
use of this medication
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Memantin (Ebixa) (10-20mg/day)Memantin (Ebixa) (10-20mg/day)
Magnesium PhysiologicalMagnesium Block
Depolarization Synaptic ActivityRestingState
Ca2+ Ca2+
–70 mV –50 mV –20 mV
Low to Moderate AffinityAntagonist Memantine(Ki = 0.5 µM)
Memantine
MM
Ca2+ M
M
Neuropharmacology, Vol 38, CG Parsons, W Danysz, G Quack. Memantine is a clinically well toleratedN-methyl-D-aspartate (NMDA) receptor antagonist—a review of preclinical data, s. 735-767.
-non-competitive NMDA-antagonist
-reduces abnormal glutamatergic activity
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CellDeath
Oxidation Inflammation
Excitotoxicity Apoptosis
Antioxidants
NMDA receptor antagonists
Anti-apoptic agents (caspase inhibitors)
Anti-inflammatory agents
Tau Hyperphosphorylation
Tau-related agents
Mitochondrial stabilizing agents
Mechanistic Rationales for Potential Disease-Modifying Therapies
MemoryDecline
CellDeath
Transmitter Deficit
Secondary Processes• Synaptic degradation• Tau hyperphosphorylation• Oxidation• Excitotoxicity• Inflammation• Demyelination• Apoptosis
• Neurofibrillary tangles• White matter changes• Atrophy
Adapted from Salloway S, et al. Alzheimers Dement. 2008;4:65-79.
Amyloid Plaque
Amyloid Beta Peptides
Rage-Ligand Inhibitors Fibrillization Inhibitors
Immunotherapy Oligomer Neutralization
Immunotherapy
Amyloid Precursor
Protein (APP)
Inhibitors/Modulators
Gamma-secretase
Beta-secretase
BACE Inhibitors
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Alzheimer disease - History of Treatment
1950 1960 1970 1980 1990 2000 2010
Cholinesterase inhibitors
NMDA antagonist
Abeta sequenced
PS1 mutation
PS2 mutation
ACh loss described
donepezil
Rivastigmine patch
tacrine
memantine
rivastigmine
galantamine
APP (Swedish)
APP (London)
ApoE4
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Goals of future research and treatment in AD2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017
Solanezumab LY2062430 III
Passive? III
Pfizer I PF04360365 II Passive c-terminus Ab-40 III
GSK I GSK933776A II
Gantenerumab Passive IIIRoche I Hucal R1450 II
Active IIIV950 IIMerck I
Active IIIPfizer/JNJ ACC-001 II
4 trials Bapineuzumab N-terminal III
Semagacestat LY450139 III
Elan: AZD-103 II A-beta aggregation inhibitor III
PF-04494700 (TTP488) II RAGE III
IV-IG III
Initiated phase III
Immunotherapies
Oral-DM
BMS BMS 708163 II GSI Mild-Mod AD III
Prodromal AD II
Pfizer GSI-953 II Begacestat Mild-Mod AD III
Elan ELND-006 II GSI III
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44
Mechanism of Action: Peripheral Sink Hypothesis
Liver clearance
CSF
Plasma
sAPP A
CTF
APP
secretase secretase
Brain
Blood-brain barrier
A
Interstitial space
A
Oligomers
Amyloid plaque
A antibody
0.1% Crosses BBBIncreased Total AβDecreased Unbound Aβ
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Vascular Dementia(DSM-IV - APA, 1994)
A. Multiple Cogntive Impairments1. Memory Impairment2. Other Cognitive Disturbances
B. Deficits Impair Social/Occupational
C. Focal Neurological Signs and Symptoms or Laboratory Evidence Indicating Cerebrovascular Disease Etiologically Related to the Deficits
D. Not Due to Delirium
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Factors Associated with Multi-infarct Dementia
History of stroke (especially in Nursing Home) Followed by onset of dementia within 3 months
Abrupt onset, Step-wise deterioration Cardiovascular disease - HTD, Atrial Fibr.
… Depression (left anterior strokes),
personality change More gait problems than in AD MRI evidence of T2 changes (??
Binswanger’s disease) Basal ganglia, putamen Periventricular white matter
SPECT / PET show focal areas of dysfunction
Neuropsychological dysfunctions are patchy
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VASCULAR DEMENTIA CHANGE ON THE MINI-MENTAL STATE EXAM
OVERTIME
< event
< event
< event
0
10
20
30
-5 0 5 10
AVERAGE TIME OF ILLNESS (years)
SC
OR
E
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Vascular Dementia: Therapy
1. P R I M A R Y P R E V E N T I O N
Stroke HT Cardiovascular risk
2. PREVENTION OF RECURRENCE
Control of risk factors HT, blood fluidity, lipids
3. SYMPTOMATIC TREATMENTVasodilatators (pentoxifyllin, naftidrofuril)Metabolic approachDrugs for Alzheimer ’s Disease
4. FUTURE DIRECTIONS
Drugs for cell deathTrophic factors
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PRIMARY PREVENTION OF VASCULAR DEMENTIA
1. TREAT HT OPTIMALLY2. TREAT DIABETES3. CONTROL HYPERLIPIDAEMIA4. TOBACCO + ALCOHOL5. ANTICOAGULANTS FOR ATRIAL FIBRILLATION6. ANTIPLATELET THERAPY7. CAROTID ENDARTERECTOMY FOR SEVERE ( 70
%) STENOSIS8. DIETARY CONTROL9. LIFESTYLE (stress, weight…)10. STROKE + TIA : NMDA, Ca++, antioxidants11. REHABILITATION
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Cochrane Review
Nimodipine (1992) : not recommended, no convincing evidence that nimodipine is a useful treatment for the symptoms of dementia (all subtypes)
Piracetam (1998) : not recommended - Effects found only on global impression of change (all subtypes of dementia)
Lecithin (1999) : results from randomized trials does not support the use of lecithin (all subtypes of dementia)
Aspirin (1999) : limited evidence that aspirin change cognitive outcome of VaD.
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the most common dementia syndrome associated with parkinsonism
the second most common form of neurodegenerative dementia after Alzheimer disease (AD).
characterized by dementia accompanied by delirium, visual hallucinations, and parkinsonism. Other common symptoms include syncope, falls, sleep disorders, and depression.
The presence of both Lewy bodies and amyloid plaques with deficiencies in both acetylcholine and dopamine neurotransmitters suggests that dementia with Lewy bodies represents the middle of a disease spectrum ranging from Alzheimer’s disease to Parkinson’s disease
Dementia with Lewy Bodies (LBD)
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Core And Supportive Features For Clinical Diagnosis Of DLB 1. The central feature required for a diagnosis of DLB is
progressive cognitive decline of sufficient magnitude to interfere with normal social or occupational function
2. Two of the following core features are essential for a diagnosis of probable DLB, and one is essential for possible DLB. Fluctuating cognition with pronounced variations in
atten- tion and alertness Recurrent visual hallucinations that are typically
well formed and detailed. Spontaneous motor features of parkinsonism.
3. Features supportive of the diagnosis are repeated falls syncope transient loss of consciousness neuroleptic sensitivity systematized delusions hallucinations in other modalities.
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FRONTOTEMPORAL DEMENTIA characterized by focal atrophy of the frontal and
temporal lobes in the absence of Alzheimer pathology Pick's disease was the first recognized subtype of FTD, one that is characterized pathologically by the presence of Pick bodies (silver staining intracytoplas. inclusions) in the neocortex and hippocampus. occurs between the ages of 35 and 75 years, and only rarely after age 75; the mean age of onset is the sixth decade both sexes are equally affected. clinically, presents with language abnormalities and behavioral disturbances.
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Frontotemporal Lobe Dementia Core Features• Insidious onset and gradual progression• Early decline in social/interpersonal conduct• Early impairment in personal conduct• Early loss of insight• Early emotional bluntingSupportive Features• Behavior disorder – hygiene, grooming, mental rigidity, dietary changes, perseverative behavior• Speech and language – perseveration, mutism, economy of speech• Physical signs – akinesis, rigidity, tremor, labile BP
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Diagnosing dementia
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BPSDActivities of daily living
DementiaDementia
Behavioural and Psychological Symptoms of Dementia:
A heterogeneous range of psychological reactions, psychiatric symptoms and behaviours resulting
from the presence of dementia
Cognitivedeficits
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mild ………...... moderate …..…...……. severe
time course of the disease
depression anxiety
psychotic symptoms (delusions, hallucinat.) verbal aggressionagitation / apathy
Loss of independence
agitation/negativism
physical aggression
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BPSD
90% of patients affected by dementia will experience Behavioral and Psychological Symptoms of Dementia (BPSD) that are severe enough to be labeled a problem at some time during the course of their illness.
(Mega et al. 1996)
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J Am Ger Soc. 1996; 44(9): 1078-1081
Behavioral Disturbances in Dementia:
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Five „I“ for investigating cause of behavioral symptoms in elderly
Iatrogenic? (anticholinergics, BZD, digitalis, diuretics…)
Inconsistency (change in routine, caregiver, or
environment?) Illness or pain?
Infection?
Is patient depressed?
• Caution! Drugs for urinary incontinence and benign prostatic hyperplasia!• Agents not crossing blood-brain barrier :
trospium (Spasmed), tolterodine (Detrusitol, Detrol),darifenacin (Emselex)
• Agents crossing blood-brain barrier : oxybutynin (Uroxal, Ditropan), propiverine (Mictonorm, Mictonetten)• Unclear: solifenacin (Vesicare), fesoterodine (Toviaz)
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BPSD that will not respond to medication
Wandering Inappropriate urination/defecation Inappropriate dressing/undressing Annoying repetitive activities
(perseveration) or vocalization Hiding/hoarding Eating inedibles Tugging at/removal of restraints Pushing wheelchair bound co-residents
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Problems that may respond to medication
Anxiety Depressive symptoms Sleep disturbance Manic-like symptoms Persistent and distressing delusions
or hallucinations Persistent verbal and physical
aggression Sexually inappropriate behavior
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Jeste, Finkel 2000
Differential Diagnosis of Psychosis of AD Vs
Psychosis of Schizophrenia in the
Elderly Psychosis of AD Schizophrenia
Bizarre or complex delusions Rare Frequent
Misidentifications of caregivers Frequent Rare
Common form of hallucinations Visual Auditory
Schneiderian first-rank symptoms Rare Frequent
Active suicidal ideation Rare Frequent
Past history of psychosis Rare Frequent
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BPSD:Treatment Patients with BPSD should be evaluated for delirium.
Consider changes in environment, medication, fecal impaction, pneumonia, urinary infection, etc.
Evaluate for needs that the dementia patient is unable to communicate normally e.g. pain
Behavioral management or situational manipulation are the initial strategies of choice for mild to moderate BPSD.
Pharmacological interventions are useful if symptoms are severe or do not respond to nonpharmacologic strategies alone
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BPSD: Nonpharmacologic Therapy
Environmental modifications such as music, plants, animals
Speak slowly, keep commands simple and positive, use gestures, gentle touch
Behavioral management techniques Structured activities and use of schedules Massage, exercise
Rowe, Alfred 1999Gerdner, Swanson 1993
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BPSD: Pharmacological Therapy Look for symptom complexes such as depression,
psychosis or anxiety to guide initial choice of agent If enlightened empiric therapy is needed, chose agents
that minimize side-effect potential and maximize chance of efficacy
In most situations, medications should be given in lower doses than are typically recommended for an adult population. However, it is noteworthy that the elderly are heterogeneous and the range of medication dosage is substantial
Ideally, use agents with demonstrable efficacy as first line agents
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BPSD: PharmacotherapySYMPTOMS PHARMACOTHERAPY
Agitation, Disinhibition, Agression, Behavioral disturbances
Antipsychotics (tiaprid, melperon, haloperidol)(Second generation antipsychotics ??)
Depression Antidepressants (avoid tricyclics)
Anxiety S1A agonits: buspironShort-acting benzodiazepins (oxazepam, lorazepam)
Circadian rhythm disturbances Hypnotics:zolpidem,zopiclon (non-bzd)melatonin, trazodone, mirtazapine
Psychotic symptoms (delusions, hallucinations)
Antipsychotics (tiaprid, melperon, haloperidol)(Second generation antipsychotics ??)
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AFP. 2003. 67: 2335-40.
Atypical Antipsychotics
Effectiveness of atypicals is firmly established in treating dementia-related psychosis
Includes Abilify (aripiprazole), Zyprexa (olanzapine), Seroquel (quetiapine), Risperdal (risperidone), Clozaril (clozapine) and Geodon (ziprasidone)
Risperidone now available in a disintegrating tablet in 0.25mg-4mg doses and a long acting injection (up to 50mg q 2 weeks) Continue oral therapy for three weeks to get
adequate level
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FDA Public Health Advisory, April 11, 2005
Risk of Atypical Antipsychotics
Class Effect 2005 - black box warning of increased risk
of death and “not approved for use in dementia-related psychosis.” Risk of death 1.6-1.7 x that of placebo Over a 10 week trial. 4.5% rate of death vs.
2.6% for the placebo group. Mostly cardiovascular deaths or infectious
(pneumonia) Patient (caregiver) specific risk assessment
and counseling