(old syllabus) pharmacy department faculty of …

(OLD SYLLABUS)

PHARMACY DEPARTMENT

FACULTY OF TECHNOLOGY & ENGINEERING

THE MAHARAJA SAYAJIRAO UNIVERSITY OF BARODA

Scheme of Teaching and Examination of B.Pharm

4 year Degree course as per AICTE Guidelines

Subject Code Subject Teaching

Examination

T

P

Pap

er

Dura

-

tion

P&T

M

TW/

Pr

Viva

Total

Mark

s

FIRST SEMESTER B.Pharm

ACH111 Physical Chemistry

ACH112 Organic Chemistry-I

AM 113 Remedial Mathematics/

PHR114 Remedial Biology

ME 115 Engg Drawing

Total

4

4

4

3

3

-

3

3

1

1

1

-

3

3

3

3

100

100

100

-

50

50

-

50

50

150

150

100

50

12 9 300 200/

150

450/

400

SECOND SEMESTER B.Pharm

PHR121 Pharm.Chem – I ( Inorg)

ACH122 Organic Chemistry –II

PHR123 Pharmaceutics-I

PHR124 Human Anat & Physiology

AM 125 Mathematics

Total

4

4

4

4

4

3

3

3

3

-

1

1

1

1

1

3

3

3

3

3

100

100

100

100

100

50

50

50

50

-

150

150

150

150

100

20 12 500 200 700

THIRD SEMESTER B.Pharm

PHR231 Médicinal Chemistry -I

PHR232 Pharm.Analysis-I

PHR233 Pharmacology -I

AM234 Intro.Computer Application

ChE235 Pharm.Engg-I

Total

4

4

4

4

4

3

3

-

3

-

1

1

1

1

1

3

3

3

3

3

100

100

100

100

100

50

50

-

50

-

150

150

100

150

100

20 9 500 150 650

FOURTH SEMESTER B.Pharm

PHR 241 Pharmacognosy -I

PHR242 Pharm.Biochemistry

PHR243 Pharmaceutics II

Ch E 244 Pharm.Engg-II

CF 245 Industrial Management

Total

4

4

4

4

4

3

3

3

3

-

1

1

1

1

1

3

3

3

3

3

100

100

100

100

100

50

50

50

-

150

150

150

150

100

20 12

500 150 650

FIFTH SEMESTER B.Pharm

PHR351 Pharmaceutics-III( Hospi.Ph)

PHR352 Pharmaceutics-IV

PHR353 Medicinal Chemistry-II

PHR354 Pharm.Microbiology

PHR355 Pharmacology-II

Total

4

4

4

4

4

-

6

3

4

-

1

1

1

1

1

3

3

3

3

3

100

100

100

100

100

-

100

50

50

-

100

200

150

150

100

20 13 500 200 700

SIXTH SEMESTER B.Pharm

PHR361 Pharm.Analysis-II

PHR362 Pharmacognosy-II

PHR363 Pharmaceutics-V

PHR364 Pharm.Biotechnology

PHR365 Pharmacology-III

Total

4

4

4

4

4

3

3

3

-

3

1

1

1

1

1

3

3

3

3

3

100

100

100

100

100

50

50

50

-

50

150

150

150

100

150

20 12

500 200 700

SEVENTH SEMESTER B.Pharm

PHR471 Pharmaceutics-VI

PHR472 Pharmacology-IV

PHR473 Pharmacognosy-III

PHR474 Medicinal Chemistry-III

PHR475 Pharm.Jurisprudence

Total

4

4

4

4

4

6

3

3

-

-

1

1

1

1

1

3

3

3

3

3

100

100

100

100

100

100

50

50

-

-

200

150

150

100

100

16 12 500 200 700

EIGHTH SEMESTER B.Pharm

PHR481 Pharm.Analysis-III

PHR482 Medicinal chemistry-IV

PHR483 Pharmaceutics-VII

PHR484 Nanotechnology

& Nanobiotechnology

PHR 485 Comprehensive Evaluation

Total

4

4

4

4

-

6

6

3

-

-

1

1

1

1

-

3

3

3

3

-

100

100

100

100

-

100

100

50

-

50

200

200

150

100

50

16 15 400 300 700

FIRST SEMESTER ACH 111 PHYSICAL CHEMISTRY B.PHARM. I

Theory 4 hrs/week Marks 100

1. Behavior of Gases : Kinetic theory of gases, deviation from behaviours and explanation.

2. The Liquid State : Physical properties (surface tension, viscosity, refractive index, optical rotation,

dipole movements and chemical constituents).

3. Solutions : Ideal and real solutions, solutions of gases in liquids, colligative properties, partition

coefficient, conductance and its measurement, Debye Huckel theory.

4. Thermodynamics : First, second, and third laws, zeroth law, absolute temperature scale, thermochemical

equations, phase equilibria and phase rule.

5. Adsorption : Fredlich and Gibbs adsorption, isotherms, Langmuir theory of adsorption.

6. Photochemistry : Consequences of light absorption, Jablenski diagram, Lambert-Beer Law, Quantum

efficiency.

7. Chemical Kinetics : Zero, first and second order reactions, complex reactions, theories of reaction

kinetics, characteristics of homogeneous and heterogeneous catalysis, acid base and enzyme catalysis.

8. Quantum Mechanics : Postulates of quantum mechanics, operators in quantum mechanics, the

Schrodinger wave equation.

Practicals

Marks 50 3 hrs/week

1. To determine molar mass by Rast method and cryoscopic method.

2. To determine refractive index of given liquids and find out the contribution of carbon, hydrogen and

oxygen in molar refraction of a compound.

3. To determine molar mass of volatile liquids by Victor-Meyer method.

4. To determine the specific rotation of sucrose at various concentrations and determine the intrinsic

rotation.

5. To determine the heat of solution, heat of hydration and heat of neutralization.

6. To determine the cell constant, verify Ostwald dilution law and perform conductometric titration.

7. To determine rate constant of simple reaction.

FIRST SEMESTER ACH 112 ORGANIC CHEMISTRY – I

B.PHARM I

Theory 4 hrs/week 100 marks

1. Structure and Properties : Atomic structure, Atomic orbitals, Molecular orbital theory, wave equation,

Molecular orbitals, Bonding and Antibonding orbitals, Covalent bond, Hybrid orbitals, Intramolecular

forces, Bond dissociation energy, Polarity of bonds, Polarity of molecules, structure and physical properties,

Intermolecular forces, Acids and bases.

2. Stereochemistry : Isomerism and nomenclature and associated physicochemical properties, optical

activity, stereoisomerism, specification of configuration, Reactions involving stereoisomers, chirality, chiral

reagents conformations.

3. Structure, nomenclature, Preparation and Reactions of : Alkanes, Alkenes, Akynes, Cycloalkanes,

Dienes, Benzene, Polynuclear aromatic compounds, Arenes, Alkyl halides, Alcohols, Ethers, Epoxides,

Amines, Phenols, Aldehydes and ketones, Carboxylic acids, Functional derivatives of carboxylic acids,

Reactive intermediates - carbocations, carbanions, carbenes, nitrene and nitrenium ions.

Practicals Marks 50 3 hrs/week

1. The student should be introduced to the various laboratory techniques through demonstrations involving

synthesis of selected organic compounds (e.g. aspirin, p-bromoacetanilide, anthraquinone from anthracine,

reduction of nitrobenzene etc.).

2. Identification of organic compounds and their derivatisaton.

3. Introduction to the use of stereomodels.

FIRST SEMESTER PHR 114 REMEDIAL BIOLOGY

B.PHARM.-I

Theory 4 hrs Marks 100

1. Plant Taxonomy: Methods of classification of plants.

2. Plant Cell: its structure and non-living inclusions; mitosis and meiosis; different types

of Plant tissues and their functions.

3. Morphology and histology of root, stem, bark, wood, leaf, flower, fruit and seed.

Modification of root and stem.

4. Study of the following families with special reference to medicinally important plants

Apocynacae, Solanaceae, Rutaceae, Umbelliferae, Leguminosae, Rubiaceae,

Liliaceae, Grarninae, Labiatae, Cruciferae, Papaveraceae.

5. General Survey of Animal Kingdom; Structure and life history of parasites as

illustrated by amoeba, entamoeba, trypanosoma, plasmodium, taenia, ascaris,

schistosoma, oxyuris, and ancylostoma.

6. General Structure and life history of insects like mosquito, housefly, mites and

silkworm.

Practical 3hrs / week Marks 50

1. Morphology of plant parts indicated in theory.

2. Gross identification of slides of structure and life cycle of lower plants / animals mentioned in theory.

3. Preparation, microscopic examination of stem, root and leaf of monocot and dicot plants

4. Structure of human parasites and insects mentioned in theory with the help of specimens

FIRST SEMESTER ME 115 ENGINEERING DRAWING

B.PHARM I

Practicals 3 hrs/week Marks 50

Elementary Knowledge of Engineering Drawing : Concept of orthographic and isometric views of elevation and third angle projection. Notation and

abbreviation used in Engineering Drawing

Basic Engineering Drawing Practice : Bolts, nuts, riveted fronts, screws, worn screws as per specification.

Drawing of simple pharmaceutical machinery parts.

.

SECOND SEMESTER PHR 121. PHARMACEUTICAL CHEMISTRY

B. PHARM. I (Inorganic Pharmaceutical Chemistry)

Theory: 4hrs/week: Marks : 100

An outline of methods of preparation, uses, sources of impurities, tests for purity and identity, including

limit tests for iron, arsenic, lead, heavy metals, chloride, sulphate and special tests If any, of the following

classes of inorganic pharmaceuticals included in Indian Pharmacopoeia.

1. . Acids and Bases: Buffers, Water

2. Gastrointestinal Agents : Acidifying agents, Antacids, Protectives and Adsorbents, Cathartics.

3. Major Intra- and Extracellular Electrolytes : Physiological ions. Electrolytes used for replacement

therapy, acid-base balance and combination therapy.

4. Essential and Trace Elements Transition elements and their compounds of

Pharmaceutical importance: Iron and haematinics, mineral supplements.

5. Cationic and anionic components of inorganic drugs useful for systemic effects.

6. Topical Agents Protectives, Astringents and Anti-infectives.

7, Gases and Vapours: Oxygen, Anesthetics and Respiratory stimulants.

8. Dental Products : Dentifrices, Anti-caries agents.

9. Complexing and chelating agents used in therapy.

10. Miscellaneous Agents : Sclerosing agents, expectorants, emetics, poisons and antidotes, sedatives etc.

Pharmaceutical Aids Used in Pharmaceutical Industry. Anti-oxidants, preservatives, filter aids, adsorbents,

diluents, excipients, suspending agents, colorants etc..

11. Inorganic Radio pharmaceuticals : Nuclear radio pharmaceuticals, Reactions. Nomenclature,

Methods of obtaining their standards and units of activity, measurement of activity, clinical applications and

dosage, hazards and precautions.

Practicals : 3 Hrs/week Marks : 50

The background and systematic qualitative analysis of inorganic mixtures of up to four radicals. Six

Mixtures to be analyzed, preferably by semi-micro methods. All identification tests for pharmacaopoeal

inorganic pharmaceuticals and qualitative tests for cations & anions should be covered.

SECOND SEMESTER ACH 122 ORGANIC CHEMISTRY-II

B.PHARM I

Theory3 hrs/week 100 marks

Nucleophillic aromatic substitution : alpha, beta- unsaturated carbonyl compounds ; Conservation of

orbital symmetry and rules. Electrocyclic, Cycloaddition and sigmatropic reactions; Neighbouring group

effects, Catalysis by transition metal complexes, Stereoselective and stereospecific reactions.

Heterocyclic Compounds : Chemistry, preparations and properties of some important heterocycles

containing 3,4,5,6 & 7 atoms with one or two heteroatoms like O, N. S, fused ring heterocyles

(Quinoline,iso Quinoline, Indole).

Practicals 50 marks 3 hrs/week

At least five exercises in synthesis involving various heterocyclic ring system. An exercise involving

stereoselective synthesis of a compound. Resolution of recemic D,L-alanine or any other example.

Workshop on molecular modelling of primary, secondary and tertiary structures of proteins, molecular

modelling on double helical structure of nucleic acid showing hydrogen bonding.

SECOND SEMESTER PHR 123 PHARMACEUTICS-I

B.PHARM.I (Dispensing & Community Pharmacy)

Theory: 4 hrs/week Marks: 100

Dispensing Pharmacy 1. Definition, scope and Ethics of dispensing practice.

2. Prescription, handling of Prescription, care required in dispensing prescription.

3. General dispensing procedure including packing and labeling of dispensed products.

4. Pharmaceutical calculations: enlarging and reducing recipes, percentage solutions, allegations, alcohol

dilution, proof spirit, Isotonic solutions and displacement values.

5 Incompatibility in prescriptions with examples.

6. Posology: Dose of commonly used drugs, alone and in combinations. Calculation of doses according to

age and other body functions. Community Pharmacy:

1. Retail Pharmacy management: Organization and structure of retail pharmacy. Layout of retail pharmacy

and other legal aspects for establishment and management of retail pharmacy. Good pharmacy practices,

maintenance of records, dispensing of Proprietary products.

2. Community Pharmacy: Study of community health care system with special references to the areas like

Nutrition( Balanced diet, nutritional deficiency disorders , their treatment and prevention) , Family

planning and family Welfare, First Aid ( shock, snake bites, burns , poisoning , fractures) and

resuscitation methods, Communicable Diseases(brief outline , their causative agents,. Modes of

transmission and prevention ( chicken pox, measles, influenza, diphtheria, whooping cough ,

tuberculosis, poliomyelitis, helminthiasis, malaria, filariasis, rabies, trachoma, tetanus, leprosy,

leprosy, syphilis, gonorrhoea and AIDS ) Immunization and Disinfection.

3. Patient counselling.

Practicals 3 hrs./week Marks:50

Dispensing of prescriptions belonging to - Mixtures, Solutions, Emulsions, Creams, Ointments,

Powders, Capsules, Pastes, Jellies, Suspensions, Ophthalmics, Pastilles, Lozenges, Pills, Liniments,

Inhalations, Paints, Sprays and Tablet triturates, Ear drops ,Incompatible mixtures

Demonstration & training of first aid.

SECOND SEMESTER PHR 124. HUMAN ANATOMY & PHYSIOLOGY

B. PHARM. I

Theory: 4 hrs/week: Marks: 100

I. Introduction .

1. Scope of anatomy and physiology

2. Study of cell and elementary tissues of the body.

II. Skeletal Muscle

3. Gross anatomy and physiology of muscsle contraction.

4. Physiological properties of skeletal muscle.

III. Haemopoetic system 5. Composition and functions of blood.

6. Blood groups and their significance

7. Mechanism of blood coagulation

IV. Digestive system 8. The Alimentary tract and its secretory functions.

9. Digestion and absorption in G.I.tract.

10. Functions of liver.

V. Respiratory system

11. The respiratory tract and pulmonary ventilation

12. Diffusion and transport of oxygen and carbon dioxide.

13. Regulation of Respiration

VI. Cardiovascular system

14. Basic anatomy and physiology of Heart

15. Specialized conducting system of Heart

¶6. Basic understanding of Heart sounds, Cardiac cycle and ECG.

17. Circulation of blood. Blood pressure and its regulation.

VII, Lymphatic system 18. Basic Physiology and functions of spleen

19. Composition and circulation of lymph.

VIII. Central Nervous System 20. Development and organization of nervous system

21. Neurone, synapse and transmitter substance

22. The cerebellum and overall motor control

23. The cerebral cortex and functions of specific cortical areas.

24. Limbic system, hypothalamus and spinal reflexes.

25. Cerebral blood flow, membranes, CSF and Brain metabolism

IX. Autonomic Nervous System

26. General organisations of ANS.

27. Basic characteristics of sympathetic and parasympathetic function and adrenal medulla.

X. Endocrine system 28. Introduction to endocrinology, the pituitary hormones and their control by hypothalamus.

29. Thyroid, parathyroid, adrenal, pancreas, their hormone and functions.

Xl. Excretory system

30. Structure and functions of kidney.

31. Physiology of urine formation.

32. Regulation of Acid base balance.

XIII. Sense organ

34. Basic anatomy and physiology of eye, ear, taste buds, nose and skin.

Practicals 3 hrs./week Marks: 50

1. Study of Microscope and Preparation of blood smear and Identification of different cells.

2. Estimation of haemoglobin in blood.

3, Differential WBC count.

4. Total RBC and Total WBC count.

5. Determination of bleeding time and clotting time.

6. Study of Human skeleton.

7. Study of different systems with the help of models.

8. Blood pressure Recording

9. Microscopic study of different tissues and organs

10. Physiological experiments on Nerve-Muscle preparation.

11. Effect of osmotic pressure on RBC.

12. Identification of Blood group.

SECOND SEMESTER AM125 MATHEMATICS

B.PHARM. I Theory 4 hrs/week Marks 100

MATHEMATICS

UNIT - 1 Ordinary Differential Equations :

Reorientation.

Modeling of Engineering system pertaining to first order differential equations (Pharmaceutical

applications), Exact differential equations, Integrating factors, Unified approach to first order ordinary

differential equation, equations of first order and higher degree.

UNIT - 2 Linear Differential Equations of Higher Order With Constant Co-efficient and with Variable

Coefficients : Homogeneous linear equation first method of solution only), Simultaneous differential

equations which are linear and of the first order, Pharmaceutical applications.

UNIT - 3 Laplace Transforms :

Laplace Transforms of elementary functions, Inverse Laplace Transforms, Linearity property, First and

Second shifting theorem. Laplace Transforms of derivative and integrals, Application of Laplace

Transform in solving ordinary and simultaneous

differential equations.

UNIT -4 Probability Theory

Review of Elementary concept in Probability, Random variable and discrete and continuous probability

distributions; Mean and variance of a distribution; Binomial and Poisson distribution and their properties;

Normal distribution curves and properties Kurtosis and skewness, sums of Independent normal random

variables, t-distribution and related results.

UNIT - 5 Statistical Inference :

Random and non-random sampling; sample size, data organization, diagrammatic representation of sample

data, bar, pie, 2-D, and 3-D diagrams, measures of central tendency, measures of dispersion, standard

deviation, Standard error of means, coefficient of variation, Parameter estimation, Testing of hypothesis,

Null hypothesis and kind of alternatives, Types of errors in tests, Tests in the case of the normal distribution

(For mean with known & unknown variance, for variance) comparison of means and variances of two

normal distributions.

UNIT - 6 Correlation and Regression :

Linear Coefficient of correlation, Methods of least-square, Regression of Yon X and X on Y, correlation

and regression analysis, elements of ANOVA, Applications in Pharmaceutical Sciences.

THIRD SEMESTER PHR 231. MEDICINAL CHEMISTRY-I

B. PHARM. II

Theory 3 hrs /week Marks: 100

1. Strategies for synthesizing the medicinally active drug molecules to be dealt in detail taking selected

examples and utilising the knowledge gained from earlier papers of organic chemistry.

2. Newer organic reagents used in drug synthesis.

3. Chemistry of amino acids and nucleic acids covering the polypeptide drugs.


Exercises based on Identification of organic compounds / drugs on the basis of functional group

analysis and derivatization.

THIRD SEMESTER: PHR 232 . PHARMACEUTICAL ANALYSIS-I

B. PHARM. II

Theory: 4 hrs / week Marks: 100

1. Significance of quantitative analysis In quality control, Different techniques of analysis, Preliminaries

and definitions, Significant figures, Rules for retaining significant digits, Types of errors, Mean deviation,

Standard deviation, Statistical treatment of small data sests, Selection of sample, Precision and accuracy.

Fundamentals of volumetric analysis, methods of expressing concentration, primary and secondary

standards. 6 hrs

2, Acid Base Titrations : Acid base concepts, Role of solvent, Hydrolysis of salts, Henderson-Hesselbach

equation, Buffer solutions, Neutralization curves, Acid-base indicators, Theory of indicators. Choice of

indicators, Mixed indicators, Polyprotic system, Polyamine and amino acid systems, Amino acid titration,

applications in assay of H3P04, NaOH, CaCO3 etc. 8 hrs

3. Oxidation Reduction Titrations : Concepts of oxidation and reduction, Redox reactions, Strengths and

equivalent weights of oxidizing and reducing agents, Theory of redox titrations, Redox indicators, Cell

representations, Measurement of electrode potential, Oxidation-reduction curves, lodimetry and lodometry,

Titrations involving ceric sulphate, potassium iodate, potassium brornate, potassium permanganate: titanous

chloride and Sodium 2,6-dichlorophenol indophenol. 6 hrs

4. Precipitation Titrations : Precipitation reactions, Solubility products, Effect of acids, temperature and

solvent upon the solubility of a precipitate. Argentometric titrations and titrations involving ammonium or

potassium thiocyanate. mercuric nitrate, and barium sulphate, indicators, Gay-lussac method; Mohr’s

method, Volhard’s method and Fajan’s method. 5 hrs

5. Gravimetric Analysis : Precipitation techniques, Solubility products; The colloidal state, Supersaturation

Go- precipitation, Post-precipitation, Digestion, washing of the precipitate, Filtration, Filter papers and

crucibles, Ignition, Thermogravimetric curves, Specific examples like benzyl penicillin, cholesterol and

histamine acid phosphate , aluminum as aluminum oxide, calcium as calcium oxalate and magnesium as

magnesium pyrophosphate, Organic precipitants. 6hrs

6. Solvent Extractions –Brief introduction , classification and theory of extraction, separation from

excipients using extraction. 5 hrs

7. Miscellaneous Methods of Analysis: Diazotisation titrations, Kjeldahl method of nitrogen estimation,

Karl-Fischer titration, Oxygen flask combustion, gasometry. 4 hrs

Practical 3 hrs /week Marks - 50

The students should be introduced to the main analytical tools through demonstrations. They should have a

clear understanding of a typical analytical balance, the requirements of a good balance, weights, care and

use of balance, methods of weighing and errors in weighing. The students should also be acquainted with

the general apparatus required in various analytical procedures.

1. Standardization of analytical weights and calibration of volumetric apparatus.

2. Acid Base Titrations : Preparation and standardization of acids and bases; some exercises related with

determination of acids and bases separately or in mixture form, some official assay procedures e.g. boric

acid should also be covered.

3. Oxidation Reduction Titrations : Preparation and standardization of some redox titrants e.g. potassium

permanganate, potassium dichromate, iodine, sodium thiosuiphate, etc. Some exercises related to

determination of oxidizing and reducing agents in the sample shall be covered. Exercises involving

potassium odate, potassium bromate, iodine solution, titanous chloride, sodium 2,6-dichlorophenol

indophenol, and ceric amnionium sulphate.

4. PrecIpitation titrations Preparation and standardization of titrants like silver nitrate and, arnmonium

thiocyanate, Titrations acording to Mohr’s, Voihard’s and Fajan’s methods.

5. Gravlmetric Analysis Preparation of gooch crucible for filtration and use of sintered glass crucible,

determination of water of hydration, Some exercises related to gravimetric analysis should be covered.

THIRD SEMESTER: PHR 233 PHARMACOLOGY-I

B.PHARM.II: (Pharmacokinetics, Pharmacolynamics & Toxiology) Theory: 4 hrs/week Marks: 100

I. Introduction:

1. Development and scope of pharmacology

2. Modern and other system of medicine

3. Definition, sources and routes of administration of drugs

II. Drug Absorption:

4. Mechanism of drug absorption

5. Absorption from vascular and non-vascular sites

6. Factors affecting drug absorption

III. Drug Distribution:

7. Factors affecting drug distribution

8. Binding of drugs to blood and tissue component

9. Protein binding and factors affecting protein binding

10. Physiological barrier to drug distribution

11. Volume of distribution and its significance

IV, Drug Biotransformation 12. Chemical pathway of drug biotransformation

13. Microsornal and non microsonial enzyme system \-

14. Factor affecting biotransformation

15. Prodrug and its application

V. Drug Excretion:

16. Renal drug excretion and concept of clearance

17. Factors affecting renal excretion

18. Non-renal route of drug excretion

19. Enterohepatic cycling of drug

VI. Principles of Pharmacokinetlcs:

20. Basic concept and rate and order of reaction

21. Plasma concentration time profile and urinary excretion data

22. Bioavailability and bioequivalence and their clinical significance

23. Application of pramacokinetic principles

24. Prologned release medication

VII. Mechanism of action of drugs:

25. Types of receptors, receptor proteins and drug receptor interaction —

26. Molecular aspect of drug action -

27. Factors modifying the effects of drug in individuals,.-

28. Pharmacokinetic and pharmacodynamic drug interaction;,

VIII. Toxicology: — —

29. Adverse drug reactions (Pharmacogenetics, hypersensitivity, teratogenicity etc.)

30 Pre clinical evaluation of drugs. (Acute, sub acute & chronic toxicity Testing)

31 New drug development and clinical trials

32. Poisons and the treatment of poisoning.

33. Non therapeutic toxicants including heavy metals and heavy metal antagonists.—

THIRD SEMESTER AM 234 INTRODUCTION TO COMPUTER APPLICATION

B.PHARM II


1. Introduction to Computers : History of Computer development, computer classification, Calculator, computers and Human burin,

Computer organization, RAM, ROM, Virtual memory, I/O devices, Hardware & Software, Computer

Languages, Low level & High level Languages, Concept of operating systems, Basic commands in MS-

DOS, UNIX and windows, Computer Networks.

2. Introduction to PC Software : MS-Word, Excel, Power Point etc. (More stress in practical)

3. C Programming Language: 1. Data types, Operators, Expressions.

2. Control flow statements : If-Else, Else-if, Switch, While, for and do while statements.

3. Pointers, Arrays.

4. Functions : Built in functions, User-defined functions, I/O functions;

5. Computer applications in pharmaceutical and clinical studies.

Practical 3 hrs /week Marks - 50

1. DOS, UNIX and windows (Basic commands)

2. Study of PC software packages like MS-Word, Excel, Power Point etc.

3. Simple programs in 'C'.

THIRD SEMESTER Ch E 235 PHARM ENGINEERING-I

B.PHARM II

Theory 3hours/week Marks : 100

1. Unit Operations : Introduction, basic laws.

2. Fluid Flow : Types of flow, Reynold's number, Viscosity, Concept of boundary layer, basic equations of

fluid flow, valves, flow meters, manometers and measurement of flow and pressure.

3. Material Handling Systems : (a) Liquid handling - Different types of pumps.

(b) Gas handling - Various types of fans, blowers and compressors.

(c) Solid handling - Bins, Bunkers, Conveyers, Air transport.

4. Filtration and Centrifugation : Theory of filtration, filter aids, filter media, industrial filters including

filter press, rotary filter, edge filter, etc. Factors affecting filtration, mathematical problems on filtration,

optimum cleaning cycle in batch filters. Principles of centrifugation, industrial centrifugal filters, and

centrifugal sedimenters.

5. Crystallization : Characteristics of crystals like-purity, size, shape, geometry, habit, forms size and

factors affecting them, Solubility curves and calculation of yields. Material and heat balances around

Swenson Walker Crystallizer. Supersaturation theory and its limitations, Nucleation mechanism, crystal

growth. Study of various types of Crystallizer, tanks, agitated batch, Swenson Walker, Single vacuum,

circulating magma and crystal Crystallizer, Caking of crystals and its prevention. Numerical problems on

yields.

6. Dehumidification and Humidity Control : Basic concepts and definition, wet bulb and adiabatic

saturation temperatures, Psychrometric chart and measurement of humidity, application of humidity

measurement in pharmacy, equipments for dehumidification operations.

7. Refrigeration and Air Conditioning : Principles and applications of refrigeration and air conditioning.

8. Material of Construction : General study of composition, corrosion, resistance, Properties and

applications of the materials of construction with special reference to stainless steel and glass.

9. Industrial Hazards and Safety Precautions : Mechanical, Chemical, Electrical, fire and dust hazards.

Industrial dermatitis, Accident records etc.

FOURTH SEMESTER PHR 241 PHARMACOGNOSY- I

B.PHARM –II

Theory: 4 hrs /week Marks : 100

1.Introduction to Pharmacognosy. Classification of crude drugs & their sources. Cultivation, collection,

processing and storage of crude drugs. .Plant hormones and their applications. Pesticides and Insecticides.

4hrs.

3.Quality control of crude drugs: Different types of Adulteration. Methods of evaluation . Including

quntitative microscopic determinations. 2hrs

4.Classification, Chemical and spectral approaches to simple molecules of natural origin.

Concept of sterioisomerisms taking examples of natural products. 4hrs.

5. Chemistry including isolation of Carbohydrates, Lipids, Proteins & Terpenoides. 10hrs

6.Physico chemical properties of Volatile oils , Resins, Tannins. 4hrs

7. Systematic pharmacognostic study of following drugs and pharmaceutical aids:. 12hrs.

Colophony, podophyllum, jalap, cannabis, capsicum, myrrh, asafoetida, balsam of tolu, balsam of peru,

benzoin, turmeric, ginger. Garnbir, black catechu, gall and myrobalan.

Mentha, Coriander, Cinnamon, Cassia, Lemon peel, Orange peel, Lemon grass, Citronella, Caraway. Dill,

Spearmint, Clove. Fennel, Nutmeg, Eucalyptus, Chenopodium, Cardamom, Valerian, Musk, Palmarosa,

Gaultheria, Sandal wood.. Agar, Guargum, Acacia, Honey, Isabgol, Pectin, Starch, Lactose, Sorbitol,

Sterculia, Tragacanth, Cellulose and its products, Sodium Alginate, Talc, and Bentonite. Besswax, Castor

oil, Qliveoil, Cocoa butter, Chaulmogra oil, Lard, Sharkliveroil, Codliver oil, Woolfat, Spermecetiwax ,

8. Studies of traditional drugs like:Amala, Kantksri, satavari, Guduchi, Giloya, Punarnava,

Chitrak,Apamarg, Gokhru, Shanlchsp ushpi, Adusa, Arjuna, Ashoka, Brahmi, Satavari, Methi, Lasun,

Guggula, Nagarmotha, Neem, Shilajit.

Practicals 3 Hours / week

Marks : 50

1. Chemical tests for general and specific constituents like carbohydrates lipids, protines.

3. Preparation of herbarium sheets.

4. Experiments on isolation & evaluation of lipids, volatile oils.

5. Morphologic, Microscopic and Chemical evaluation of crude drugs mentioned in theory.

FOURTH SEMESTER: PHR 242 PHARMACEUTICAL BIOCHEMISTRY

B.PHARM II


1. Biochemical organisation of the cell and transport processes across cell membrane.

2. The concept of free energy, determinational of change in free energy from equilibrium constant and

reduction potential , bioenergetics, production of ATP and its biological significance.

3. Enzymes : Nomenclature, enzyme kinetics and its mechanism of action, mechanism of inhibition,

enzymes and iso-enzymes In clinical diagnosis.

4. Co-enzymes : Vitamins as co-enzymes and their significance. Metals as co-enzymes and their

significance.

5. Carbohydrate Metabolism; Conversion of polysaccharide to glucose- 1- phosphate, Glycolysis and

fermentation and their regulations, Giuconeogenesis and glycogenolysis, Metabolism of galactose and

galactosemia, Role of sugar nucleotides in biosynthesis and pentosephosphate pathway.

6. The citric Acid cycle: Significance, reactions and energetic of the cycle, Amphibolic role of the cycle,

and Glyoxalic acid cycle.

7. Lipids Metabolism : Oxidiatio of fatty acids, B-oxidation & energetic, a- oxidation of fatty acids, B-

oxidation & energetic , a-oxidation, w-oxidation, Biosynthesis of ketone bodies and their utilization,

Biosynthesis of saturated and unsaturated fatty acids, control of lipid metabolism, Essential fatty acids &

eicosanoids (Postagglandian, thromboxanes and leukotrienes), phoapholipids, and spshingolipids.

8. Biological Oxidation: Redox- potential, enzymes and co-enzyzmes involved in oxidation reduction & its

control. The respiratory chain, its role in energy capture and its control. Energies of oxidative

phosphorylation, Inhibitors of respiratory chain and oxidative phosphorylation, Mechanism of oxidative

phosphorylation.

9. Nitrogen & Sulphur cylce: Nitrogen fixation, ammonia assimilation, nitrification and nitrate assimilation,

sulphate activitation, sulphate reduction, Incorporation of sulphur in organic compounds, release of sulphur

from organic compounds.

10. Metabolism of Ammonia and Nitrogen containing Monomers: Nitrogen balance, Biosynthesis of amino

acids, catabolism of amino acids, conversion of amino acids, to specialezed products. Assimilation of

ammonia, Urea cycle, metabolic disorders or urea cycle. Metabolism of sulphur containing amino acids,

porpphyrin biosynthesis ,formation of bile pigments, hyperbiliruninemia, purine biosynthesis, purine

nucleotide intereconversion, pyrimidine biosynthesis, and formation of deoxyribounucleotides.

ii. Biosynthesis of Nucleic Acids: Brief introduction of genetic organisation of the mammalian genome,

alteration and rearrangements of genetic material, Biosynthesis of DNA and its replication. Mutation,

physical & chemical mutagenesis/carcinogenesis, DNA repair mechanism, Biosynthesis of RNA.

12. Genetic code and protein synthesis: Genetic code components of protein synthesis, brief account of

genetic

engineering and polymerase chain reactions.

13. Regulations of gene expression.

Practicals 3 hrs/week

* Practical based on theory will be conducted Marks: 50

THIRD SEMESTER PHR 243 -PHARMACEUTICS-Il

B.PHARM.II (Physical Pharmacy)


1. Solubility and Distribution Phenomena:

Definitions, expressions, solute-solvent interactions. Solubility of gases, liquids and solids-factors affecting

their solubility. Distribution -law, coefficient, pharmaceutical applications of partition coefficient.

2. Micrometrics:

Particle size and distribution, average particle size, particle size distribution, number and weight

distribution, particle number, methods for determining particle size, optical microscopy, sieving,

sedimentation, particle volume measurement, particle shape, specific surface, methods for determining

surface area, permeability method, adsorption method; Derived properties of powders-porosity-packing

arrangement- densities bulkiness, flow properties.

3, Surface and Interfacial phenomena

Liquid interfaces- surface and interfacial tensions, surface free energy, measurement of surface and

interfacial tensions, spreading coefficient, adsorption at liquid interfaces, surface active agents-HLB

classification, solubilization-detergency, adsorption at solid interfaces, solid -gas and solid -liquid

interfaces, complex films. Electrical properties of interfaces.

4. Viscosity and Rheology;

Newtonian systems- Low of flow, kinematic viscosity, effect of temperature, Non-newtonian systems-

pseudoplastic dilatant, plastic- thixotropy, measurement thixotropy, thixotropy in formulation ,

determination of viscosity- capillary, falling ball- rotational viscometers.

5. Disperse systems:

(a) Colloidal Dispersions- pharmaceutical applications, types- lyophilic, lyophobic, association colloids,

properties of colloids.

(b) Coarse dispersions- Suspensions and Emulsions;

Interfacial properties of suspended particles, settling in suspensions- theory of sedimentation-effect of

Brownian movement -sedimentation of flocculated particles, sedimentation parameters, wetting of particles,

controlled flocculation.

Emulsions- types- theories of emulsification, physical stability of emulsions.

6. Complexation:

Classification, methods of preparation and analysis, Applications.

7. Kinetics and drug stability :

General consideration and concepts, orders of reaction, half life determination, influence of temp. , light,

solvent, catalytic species and other factors, accelerated stability study, expiration dating.

Practical : 3 hrs week Marks :50

Experiments devised to determine complexation and complex stability, kinetics and orders of reaction,

average particle size, particle size distribution, particle surface areas. bulk density of powders, flow

properties of powders, solubility of solids, partitioning of salutes in immiscible solvents, surface and

interfacial tensions, HLB values, adsorption of solutes on solids, viscosity, Rheological properties of

liquids, optical and electrical properties of colloids, gelling property, sedimentation rates of non-flocculated

and flocculated systems, creaming and cracking of emulsions etc, and other

experiments of illustrate the topics covered in theory.

FOURTH SEMESTER PHR 244 PHARM ENGINEERING – II

B.PHARM II


1. Stoichiometry : Unit processes material and energy balances, molecular units, mole fraction, tie

substance, gas laws, mole volume, primary and secondary quantities, equilibrium state, rate process, steady

and unsteady states, dimensionless equations, dimensionless foumulae, dimensionless formulae,

dimensionless groups, different types of graphic representation, mathematical problems.

2. Heat Transfer : Source of heat, heat transfer, steam and electricity as heating media, determination of

requirement of amount of steam/electrical energy, steam pressure, Boiler capacity, Mathematical problems

on heat transfer.

3. Evaporation : Basic concept of phase equilibria, factor affecting evaporation, evaporators, film

evaporators, single effect and multiple effect evaporators, Mathemical problems on evaporation.

4. Distillation : Raoult's law, phase diagrams, volatility; simple steam and flash distillations, principals of

rectification, Mc. Cabe Thiele method for calculations of number of theoretical plates, Azeotropic and

extractive distillation. Mathematical problems on distillation.

5. Drying : Moisture content and mechanism of drying calculations; classification and types of dryers,

dryers used in pharmaceutical industries and special drying methods. Mathematical problems on drying.

6. Size Reduction and Size Separation : Definition, objectives of size reduction, factors affection size

reduction, laws governing energy and power requirements of a mills including abll mill, hammer mill, fluid

energy mill etc.

7. Mixing : Theory of mixing, solid-solid, solid-liquid and liquid-liquid mixing equipments.

8. Automated Process Control Systems : Process variables, temperature, pressure, flow, level and their

measurements. Elements of automatic process control and introduction to automatic process control

systems. Elements of computer aided manufacturing (CAM).

9. Reactors and fundamentals of reactors design for chemical reactions.

Practicals:

Practicals 4 hrs / week Marks: 50

1. Determination of overall heat transfer coefficient.

2. Determination of rate of evaporation.

3. Experiments based on steam, extractive and azeotropic distillations.

4. Determination of rate of drying, free moisture content and bound moisture content.

5. Experiments to illustrate the influence of various parameters on the rate of drying.

6. Experiments to illustrate principles of size reduction, Laws governing energy and power requirements

of size Reduction.

7. Experiments to illustrate solid-solid mixing, determination of mixing efficiency using different types

of mixers.

FOURTH SEMESTER CF PHR 245 INDUSTRIAL MANAGEMENT

B.Pharm II ( taught by commerce faculty)

FIFTH SEMESTER PHR 351 . PHARMACEUTICS-III B.PHARM.IV (Hospital Pharmacy)

Theory 4 hrs./week

Marks : 100

1, Organisation and Structure: Organisation and structure of Hospital and Hospital Pharmacy

Responsibilities of a Hospital Pharmacist. Pharmacy and therapeutic committee.

2. Drug distribution systems in Hospitals: Inpatient and out patient drug distribution, Dispensing of

Narcotic and other controlled substances, ancillary substances and articles. Changing policy and systems for

hospital supplies and drugs.

3. Manufacture of Hospital products and sterile extemporaneous preparations:

a) Intra venous fluids: Facility requirements, formulation, preparation and packing

b) Special electrolytes

c) Blood products and plasma expanders

d) Surgical dressings: Ligature and sutures.

5. Handling and administration of sterile products: Injections-IMIIV, Catheters, IV Infusions Volume

control sets, Over the needle catheters (ONC), Intermittent IV therapy. Complications in IV therapy. Other

parenteral and implantable devices. Parenteral Admixtures and incompatibilities.

6. Hospital formulary and other hospital publications.

7. Drug information services.

Sources of information and procurement, computerization of services like prescription filling, drug profile,

patient medication profile, drug interaction and adverse reaction, idiosyncratic cases etc.

8. Medication errors, documentation and preventive measures.

9. Central sterile supply unit and its management.

10. Nuclear Pharmacy : Introduction to radiopharmaceuticals, preparation of radiopharmaceuticals in

hospital and their standardization. Radiation dosimetry radiation hazards and their prevention.

Specifications for radio isotope laboratory.

FIFTH SEMESTER PHR 352 ( PHARMACEUTICS-IV)

B. PHARM.III (Pharm. Technology-I)

Theory 4 hrs/week Marks : 100

1. Liquid Dosage Forms

Introduction, type, additives used in formulations, vehicles, stabilizers, preservatives, suspending agents,

emulsifying agents, solubilizers, colours, flavours and others. Manufacturing, packing and evaluation of

clear liquids, suspensions and emulsions for oral and topical administration. Liquid preparation official in

Pharmacopoeia.

2. Semisolid dosage forms

Definitions, types, mechanism of drug penetration through skin, factors influencing penetration. Semisolid

bases and their selection.

General formulation of semisolids, manufacturing procedures, evaluation and packaging.

3. Suppositories

Ideal requirements, bases, manufacturing procedure, packaging and evaluation.

5. Pharmaceutical Aerosols

Definitions, propellents, formulation, manufacturing and packaging, evaluation and applications.

6. Cosmeticology and Cosmetics:

Fundamentals of cosmeticology, materials and additives used in cosmetics and their specifications,

structure and functions of skin, hair, nails , eyes, preparation and packing of cosmetics for skin, hair,

dentifrices, manicure preparations, nail polish, lipsticks, eye cosmetics, baby care products etc.

7. Packing, levels of packaging, Raw materials in packaging and their specifications and testing

Practicals 6 hrs/week Marks : 100

1. To study the influence of emulsifier, HLB and formulation method on the stability of emulsions.

2. To prepare various liquid orals like solutions, syrups, elixirs, gels, mixtures, suspensions, emulsions etc.

3. To prepare various topical formulations like lotions, liniments, glycerites, paints, applications etc.

4. To prepare various semisolid preparations like ointments, pastes, jellies, poultices etc.

5. To prepare suppositories.

6. To prepare various cosmetics like cold creams, vanishing cream, hair cream, shampoo, deodorants, nail

polish, eye shadow, mascara, tooth paste, tooth powers, mouth wash, lipsticks, shampoo, face powder,

shaving cream, after shave lotion etc.

7. Other practicals covering the theory.

FIFTH SEMESTER PHR 353. MEDICINAL CHEMISTRY-Il

B. PHARM. III Theory 3hrs/week Marks: 100

1. Basic Principles of Medicinal Chemistry : Physico-chemical aspects (Optical, geometric and

bioisosterism) of drug molecules and biological action, Drug-receptor interaction including transduction

mechanisms.

2. Amino acids, peptide, nucleotides and related drugs.

i) Thyroid and Anti thyroid drugs

ii) Insulin and oral hypoglycaemic agents.

iii) Peptidomimetics and nucleotidomimetics.

iv) Diagnostic agents.

v) Pharmaceutical Aids.

3. Synthetic procedures of selected drugs, mode of action, uses, structure activity relationship including

physicochemical properties of the following classes of drugs

A. Drugs acting at Synaptic and neuro-effector junction sites

i. Cholinergics and Anticholinesterases

ii. Adrenergic drugs

iii. Antispasmodic and anti ulcer drugs

iv. Neuromuscular blocking agents.

B. Autocoids

i. Antihistamines ii. Eicosanoids

ii. Analgesic-antipyretics, anti-inflammatory (non-steroidal) agents

C. Drugs affecting uterine motility

Oxytocics (including oxytocin, ergot alkaloids and prostaglandins)

Biochemical approaches in drug designing wherever applicable should be discussed.

Practicals 3 hrs / week Marks: 50 1. Workshop on stereomodel use of some selected drugs.

2. Synthesis of selected drugs from the course content.

3. Spectral analysis of the drugs synthesized.

4. Establishing the pharmacopoeial standards of the drugs synthesized.

5. Determination of partition, coefficient, dissociation constant and molar refractivity of compounds for

OSAR analysis.

FIFTH SEMESTER PHR 354. PHARMACEUTICAL MICROBIOLOGY

B. PHARM. III

Theory 4 hrs I week Marks: 100

I. Introduction to the scope of microbiology.

2. Bacterial cell cytology.

3. Classification of microbes and their taxonomy; bacteria, fungi.

4. Identification of Microbes: stains and types of staining techniques, electron microscopy.

5. Nutrition, cultivation, isolation and enumeration of bacteria, fungi, viruses, etc.

6. Microbial genetics and variation.

7. Control of microbes by physical and chemical methods.

a) Disinfection, factors influencing disinfectantion, dynamics of disinfection, disinfectants and antiseptics

and their evaluation.

b) Sterilization, different methods, validation of stserilization methods & equipments.

8. Sterility testing of all pharmaceutical products.

9. Immunity, primary and secondary, defensive mechanisms of body, microbial resistance, interferon.

10. Microbial assays of Antibiotics, Vitamins and amino acids.

Practicals 4 hrs / week Marks: 50

Experiments devised to prepare various types of culture media, subculturing of common aerobic and

anaerobic bacteria, fungus and yeast, various staining methods, various methods of isolation and

identification of microbes, sterilization techniques and their validation evaluation of antiseptics and

disinfectants, testing the sterility of pharmaceutical products as per l.P. requirements, microbial assay of

antibiotics and vitamins total microbial counts in raw materials and pharmaceutical preparations.

FIFTH SEMESTER PHR 355. PHARMACOLOGY-II

B.PHARM.III (Pharmacological Studies of Chemical Mediators)

Theory 4 hrs/week Marks: 100

I Chemical Mediators and Autonomic Nervous System:

I. Introduction

2. Some general principles of chemical transmission

3. Mechanism of transmitter release

4. Basic steps in neurochemical transmission-site of drug action

II. Cholinergic Transmission:

5. Muscarnic and nicotinic actions of cholinergic agonists.

6 Effects of drugs on cholinergic transmission (anticholinesterases).

7. Drugs affecting muscarnic receptors ( anti musarnic agents)

8. Drugs affecting autonomic ganglion.

9. Neuromuscular -blocking drugs.

III. Noradrenergic Transmission:

10. Classification of adrenoceptors.

11. Drugs acting on adrenoceptors.

12. Drugs affecting adrenoceptors ( a and b blockers)

13. Drugs that affect adrenergic neurones.

IV. Other Peripheral Mediators:

14. 5-hydroxytryptarnine & the treatment of migraine

15. purines.

V. Peptides and Proteins as Mediators: 16. General principals of peptide pharmacology

17. Biosynthesis and regulation of peptides

18. Peptide antagonists.

19. Protein and peptide as drugs.

VI. Nitric Oxide:

20. Biosynthesis of nitric oxide and control.

21. Effect of nitric oxide.

22. Therapeutic use of nitric oxide and nitric oxide donors.

23. Clinical condition in which nitric oxide may play a part.

VII. Local Hormones, Inflammation and allergy: 24. The acute inflammatory reaction and immune response.

25. Outcome of inflammatory response.

26. Mediators of inflammation and allergy (Prostaglandins, histamine etc.)

27. Non-steroidal and inflammatory drugs.

28. Antirheumatoid drugs.

29. Drugs used in gout.

30. Antagonists of histamine.

31. Immnosuppresant drugs & immunomodulators.

SIXTH SEMESTER PHR 361. PHARMACEUTICAL ANALYSIS - II

B. PHARM. III

Theory 4 hrs / week Marks: 100

Theoretical considerations, and application in drug analysis and quality control of the following analytical

techniques

1. Non-aqueous titrations 4hrs

2. Complexometric titrations 4 hrs

3. Chromatography –Theoretical aspects and simple chromatographic techniques

Column, paper, TLC and HPTLC . 6 hrs

Theory instrumentation and applications of the following techniques :

4. Potentiometry 5 hrs

5. Conductometry 4 hrs

6. Coulometery 3 hrs

7. Polarography and amperometery 6 hrs

8. R.I.A 4 hrs

9. X-ray Diffraction 4 hrs

Practicals 3 hrs / week Marks 50

I. Non aqueous Titrations : preparation and standardization of perchioric acid and sodium/potassium/lithium

methoxides solutions; Estimations of some pharmacopoeial products.

2. Complexometric Titrations : Preparations and standardization of EDTA solution, some exercises related

to pharmacopoeial assays by complexometric titrations.

3. Miscellaneous Determinations Exercises involving diazotisation, Kjeldahl, Karl-Fischer, Oxygen flask

combustion and gasometry methods. Determination of alcohol content in liquid galenicals, procedure (BPC)

shall be covered.

4. Experiments involving separation of drugs from excipients.

5. Chromatographic analysis of some pharmaceutical products.

6. Exercises based of acid base titration in aquqeous and non-aqueous media, oxidation-reduction titrations

using potentiometric technique, Determination of acid-base disassociation constants and plotting of titration

curves using pH meter.

7. Exercises involving Polarimetery.

8. Exercises involving conductometric and polarographic techniques.

SIXTH SEMESTER PHR 362. PHARMACOGNOSY- II

B. PHARM. III Theory 4 hrs/week Marks: 100

1. General techniques of biosynthetic studies including radio-tracer techniques. Basic

metabolic pathways. Description of schemes of biosynthesis of secondary metabolites of pharmaceutical

importance. 6 hrs.

2. Phytochemical screening: different extraction methods.Screening the extracts for presence of alkaloids,

saponins, cardenolides and bufadienolides, flavonoids , leucoanthocyanidins, tannins , polyphenols,

anthraquinones, cynogenetic glycosides, and amino acids etc. 4 hrs.

3. Nature, distribution, classification, general methods of isolation and properties of

Alkaloids & Glycosides. 4 hrs.

4. Chemistry, including biogenesis,isolation and pharmacological activity of atropine,

reserpine, ephedrine, ergometrine, quinine,morphine, digitoxin, sennosides, diosgenin,

carotenoides, flavanoides and related compounds. 12 hrs.

5. Systematic pharmacognostic study of drugs like: Tobacco, Belladonna, Hyoscyamus,

Datura, Coca, Withania, Cinchona, Ipecac, Opium, Ergot, Rauwolfia, Vinca, Nuxvomica,

Physostigma, Pilocarpus, Veretrum, Kurchi, Epedra, Solanum, Tea, Colchicum ,Digitalis, Rhubarb,

SolanumSpp., Cascara, Scilla, Liquorice,Senna, Aloes, Wild cherry, Bitter Almond.

12 hrs.

6. Natural allergens and photosensitizing agents and fungal toxins.

Herbs as hearth foods. 2hrs.

Practical 3 hrs/week

Marks: 50

1. General chemical tests for alkaloids, glycosides, steroids, flavonoids and tannins.

2. Evaluation of crude drugs listed in theory including Study of powdered drugs.

3. Isolation of few alkaloid and glycosides.

SIXTH SEMESTER PHR 363 PHARMACEUTICS-V

B.PHARM.III (Biopharmaceutics & Pharmacokinetics)

Theory . 4 hrs/week Marks: 100

1. Introduction to Biopharmaceutics and Pharmacokinetics, various terms used and their role in related

discipline.

2. Bio-pharmaceutics.

Definition, physico-chemical factors altering biological performance of drugs with special emphasis on pH,

partition hypothesis, dissolution rate. Physiological considerations including membrane, gastro-intestinal

physiology arid environment like presence of food, motility etc. Influence of formulation factors on

absorption of drugs.

3. Bio-availability and bio-equivalence; concept and significance; Methods of determination of bio-

availability using blood level and urinary excretion data. Parameters and protocols used to evaluate bio-

equivalence.

3. Pharmaco-kinetlcs

(i) Absorption, distribution, metabolism and excreation of drugs, protein binding, Pharmacokinetic

parameters, determinations and their significance.

(U) Compartment kinetics: One and two compartment models, pharmacokinetics of single dose

administration as applied to intravenous bolus and oral administration. Pharmacokinetic basis for sustained

release formulations. Micheelis-Menten elimination kinetics.

(Ni) Two compartmental model: elimination kinetics, pharmacokinetics of single, multiple and sustained

release formulations Wagner-Nelson methods of estimation. Curve fitting, method of residuals as applied to

plasma concentration profile for two compartment model. Area under the curve estimations.

(iv) Brief Introduction to non -linear pharmacokinetics: Concepts and applications.

(v) Kinetics of multiple dosing and dosage regimen.

(vi) Urinary excretion, computation of pharmacokirietic parameters from urine data. Dosage regimen

adjustment in pateints with and without renal failure.

Practlcals 3 hrs/week Marks; 50

1. Experiments designed to determine bioavailability, bioequivalence of selected drug(s) by urinary salivary

excretion or blood level data.

2. Experiments designed to determine pharmacokinetic parameters of selected drug(s) from blood

level/urinary excretion data.

3. Mathematical modeling, curve fitting, area under the curve determination etc.

SIXTH SEMESTER PHR 364. PHARMACEUTICAL BIOTECHNOLOGY

B. PHARM. III (Biological Pharmacy and Fermentation)

Theory 4 hrs/week Marks: 100

1. Immunology & Immunological preparations:

Immune systems, cellular, humoral immunity, antigens, antibody, antigen-antibody reactions and their

applications:

hypersensitivity, active and passive immunization, vaccines - their preparation, standardization and storage.

Hybridoma technology; monoclonal antibody production & its applications.

2. Genetic Reconibinatlon

Transformation, transduction, conjugation, protoplast fusion, Gene cloning and its applications.

3. Fermentation

Types, design of fermenter, nutrients, sterilization of media and equipments, Production and recovery of

Penicillin, citric acid, vitamins and enzymes etc.

4. Microbial Transformation : Introduction, types of reactions mediated by microorganisms, design of

biotransformation processes, selection of organisms, biotransformation process and its improvements with

special reference to steroids.

5. Enzymes:

Study of enzymes; hyaluronidase, penicillinase, streptokinase, streptodornase, amylases, proteases etc.

Immobilization of enzymes, bacteria and plant cells.

SIXTH SEMESTER PHR 365 PHARMACOLOGY-III

B.PHARM.III (Clinical & Pharmacological Study of Major Organ Systems)

Theory 4 hrs/week Marks : 100

I. The Heart

1.Pathophysiology of C.C.F.

2. Drugs used in C.C.F.

3. Pftthophysiology of cardiac arrhythmia.

4. Anti arrhythrnic drugs.

II. The Vascular System:

5. Pathophysiology of hypertension.

6. Anti- hypertensive drugs.

7. Pathophysiology of isehemic heart disease.

8. Drugs used in the treatment of angina and myocardial infaction.

9. Pathophysiolo9y of atherosclerosis.

10. Lipoprotein transport in the blood & lipid lowering drugs.

III. The Haemopoietic system:

11. Disorders of blood coagulation.

12. Drugs that act on coagulation cascade

13. Anti-platelet nd ttwombolytic agents.

14. lron,folic acid and vitamin B-12

15. Haemopoietic growth factors.

IV. The Respiratory system:

16. Disorders of respiratory function.

17. Drugs used in bronchial asthma and other respiratory disorders.

V. The kidney -

18. Diuretics and their clinical application.

VI. The Gastrointestinal system:

19. Pathophysiology of peptic ulcer.

20. Drugs used in the treatment of acid-peptic disorders.

21. Drugs used in vomiting.

22. Drugs affecting the gastrointestinal motility & billiary system.

23. Drugs for the chronic inflammatory bowel disease.

VII. The Central Nervous system:

24. Neurotransmitters of central nervous system.

25. Neurodegenarative disorders and their treatment

26. General and local anaesthetic drugs.——

27. Pharmacotherapy of anxiety and Insomnia.

28. Pathophysiology and management of schizophrenia.

29. The nature of affective disorders and antidepressant drugs.

30.Different forms of epileptic disorders and the management of epilepsy.

31. 4pioIds and other analgesics.

32 Respiratory stimulants, psychomotor stimulants and psychomimetic drugs.

33. Alcohol, Drug dependence and drug abuse.

Practicals : 3 hrs/week Marks 50

1. Introduction to experimental pharmacology.

2. Study of concentration response curve of acetyladine on Frog rectus abdoniinis muscle preparation.

3. Modification of responses to acotnjcraline on Frog Rectus by atropine, neostigmine and pancuronium.

4. Modification of responses to acetyladine Histamine and Bad2 by atropine and antihistaminic on smooth

muscle preparation.

5. Estimation of concentration of acetyladine Histamine and Adrenaline using suitable biological

preparation from Frog, Rat, Guinea pig and Rabbit by log dose or matching method.

6. Study of competitive and non- competitive antagonism.

7. calculation of EC 50 and PA2 values and its significance.

8. Study of Mydriatics and miotics on Rabbit eye.

9. Study of lnotropic and chronotropic effects of drugs on perfused Frog heart and its modification by

Atropine and propranolol.

SEVENTH SEMESTER PHR 471 PHARMACEUTICS VI

B. PIIARM (Pharmaceutical Technology-Il)

Theory 4 hrs/week 100 Marks

1. Capsules:

Formulation, production and evaluation and packing of hard and soft capsules including quality control,

stability testing and storage.

2. Tablets:

(a) Formulation of different types of tablets, Granulation, technology of production of granules on large

scale by various techniques. Physics of tablets making, tablet compression machinery of different types of

tablets.

(b) Coating of Tablets: Types of coating , film formers, formulation of coating solution, coating

equipments, coating process , evaluation of coated tablets.

(C) Packaging of tablets: Raw materials in packing tablets, specifications and evaluation. Strip

packing and blister packing of solid formulations 3. Parenterals ( Sterile products):

a) Preformulation factors, routes of administration.

b) Vehicles: Water for injection, pyrogenicity, non aqueous vehicles.

c) Formulation details

d) Containers, closures, their selection, specification and testing.

e) Prefilling treatment, washing of containers and closures

e) Preparation and filling of solutions, suspensions, ampoules, vials, infusion fluids, sterile and lyophilised

powders, equipment for large scale manufacture.

f) Evaluation of sterile products

g) Aseptic techniques,- sources of contamination, methods of prevention, design of aseptic area, laminar

flow bench services and maintenance.

4. Opthalmic preparations:

Requirement, formulation, Methods of preparation, packing and evaluation.

5. Sustained and Controlled Release Products:

(a) Design, development and evaluation of oral and injectable sustained release products

(b) Microencapsulation- Importance, techniques, application.

Practicals 6 hrs/week Marks: 100

Preparation and evaluation of various types of:

(i) Capsules

(H) Tablets, conventional, sugar coated, film coated, dispersible etc.

(iii) Parenterals - Small volume injectables, Large volume parenterals, Aqueous and oily based injections.

(iv) Ophthalmic products - eye drops, eye ointments.

(v) Sustained and controlled release formulations of various types.

(vi) Microcapsules by various techniques.

(vii) Novel drug delivery systems like implants, inserts etc.

SEVENTH SEMESTER PHR 472. PHARMACOLOGY-lV

B.PHARM.IV (Clinical & Pharmacological Study of Hormones, Neoplastic &

Infectious Disease) Theory 4 hrs/week Marks: 100

I. Hormones:

1. Hormones of hypothalamus

2. Pharmacology of anterior and posterior pituitary hormones.

3. Papthophysiology of diabetes mellitus.

4. Insulin and oral hypoglycemic agents.

5. Adrenocorticosteroids and synthetic analogs.

6. Female sex hormones and oral contraceptives.

8.. Androgens and anabohc steroids

9. Oxytocics and uterine relaxants.

10. Thyroid and anti-thyroid drugs.

11. Caicitonin, parathyroid hormone and the treatment of osteoporosis.

II Chemotherapy of Malignant Disease:

12. Basic principal of chemotherapy

13. The biology of cancer.

14. Drugs used in cancer chemotherapy

15. Resistance to anti-cancer drugs.

16. Possible future strategies for cancer chemotherapy.

III. Chemotherapy of Infectious disease:

17. Antimicrobial agents which interfere with the synthesis of folate.

13. Beta-lactam antibiotics.

19. Antimicrobial affecting bacterial protein synthesis

20. Antimicrobial affecting topoisomerase V.

21. Miscellaneous antibacterial agents.

22. chemotherapy of tuberculosis and leprosy.

23. Antiviral drugs.

24. Treatment of AIDS

25. Antifungal drugs.

26. Antiprotozol drugs.

27. Anthelminthic drugs.

IV. Vitamins & Minerals:

28. Vitamin deficiency diseases and their management.

29. Role of minerals in health &diseases.

Practicals 4 hrs/week Marks : 50

1. Estimation of the concentration of Oxytocin, 5HT and Histmine using suitable biological preparation by log dose or

three point assay method.

2. Estimation of concentration of pancuronium using Frog rectus abdominis preparation by percentage inhibition

method.

3. Demonstration of the effect of various drugs on cad blood pressure and its modification by antagonists.

4. Study of mucarinic and micotinic acations of acetylcholine on cat blood pressure.

5. Study of anticonvuslant effect of phenytoin against maximal elctroshock induced convulsions in mice.

6. Study of anti-inflammatory effect of NSAIDs against hind paw edema in rat.

7. Study of antipsychotic effect of phenothiazine in rats using Cook’s pole climbing apparatus.

8. Study of analgesic effect In mice using tail flick or acetic acid induced writhing.

9. Study of drug affecting locomotor activity using actophotometer.

10. Basic consideration and procedure involved in pyrogen testing.

SEVENTH SEMESTER PHR 473. PHARMACOGNOSY - III

B. PHARM. IV Theory 4 hrs/week Marks: 100

1 Brief account of plant based Industry and Institutions involved in work on medicinal and aromatic plants in India.

2 hrs

2. Phyto Pharmaceuticals : Detailed method of isolation/ estimation of following in plant extracts and formulations:

Atroptine ,Quinine, Ephedrine, digoxin, Ca-Sennosides, Diosgënin, Glycerrhizin, Citrus Bioflavanoids, Rutin

Andrographolides, Phyllanthin Guggul Lipids, Gimnemic acid, Asiaticosidè Withanoloides, Wedelolactone.

8 hrs.

3.Basic principles of Therapy in alternative systems of medicine like Ayurveda, Siddha, Unani, Chinese and

Homeopathy. 4 hrs.

4. Herbal Formulations: Basic principles involved in the preparation of formulation in Ayurveda like Aristas, Asava,

Ghutika, Churna Avalehas Bhasmas, etc. and their evaluation.Determination of alcohol content in Aristas and asavas

4 hrs.

5.Herbal Cosmetics : Study of role of herbs like : Soapnut,: Amla, Henna, Hybiscus, Tea,: Amla, Henna, Aloe-vera,

Glycyrrhiza, Turmeric, Sandalwood.etc. 2 hrs.

6. Standardisation of Herbals : GMP IN Ayurveda.and salient features of Schedule T of Drugs and Cosmetics act of

India. Details of WHO guidelines for the assessment of Herbal products including study of newer analytical

techniques including (HPLC, HPTLC). Study of methods used to detect and estimate the amount of heavy metals in

Herbal Preparations (Mg, Cu, Zn, As etc.). Patenting of Natural Products. 8 hrs.

7. Plant Biotechnology:Plant genetics (Polyploidy, Mutation & Hybridization).Tissue Culture: (a) Callus &

Suspension cultures,(b) Production of Secondary metabolites.

(c) Biotransformation, imrnobilisation of cells and enzymes. Gene transfer in plants using vectors and physical

delivery methods. Applications of plant biotechnology. 4 hrs.

8. Plant bitters and sweeteners. Novel medicinal agents from marine sources. 2 hrs.

9. Enzyme Biotechnology (a) Introduction, General methods of Isolation and purification of enzymes, enzyme

reactors. (b) Source, method of preparation, chemical nature and uses of Papaine, Bromelaine.

4 hrs.

Practicals 3 hrs/week

Marks50

Isolation of some Phyto constituents mentioned in theory and their estimation in natural sources using

chromatographic or other recommended methods.

Determination of heavy metals in crude drugs. Some experiments on plant tissue culture.

Evaluation of herbal drug preparation using Thin layer and paper chromatography.

SEVENTH SEMESTER PHR 474. MEDICINAL CHEMISTRY III

B. PHARM. IV Theory 4 hrs/week Marks : 100

Synthetic procedures of selected drugs, mode of action, uses, structure activity relationship including Physico-

Chemical properties of the following classes of drugs:

1. Steroids and related drugs : Steroidal nomenclature and stereochemistry, androgens and anabolic agents, estrogens,

and progestational agents, adrenocorticoids.

2. Drugs acting on the Central Nervous System: General Anesthetics, Local Anesthetics, Hypnotics and Sedatives,

Opioicl analgesics, antitussives, anticonvulsants, Antiparkinsonisrn drugs, CNS stimulants, Psychopharmacological

agents (neuroleptics, antidepressants, anxiolytics).

3. Diuretics, Cardiovascular drugs (Antihypertensiv , antiarrythmic, antihyperlipidemic agents , Cardiotonics and

antianginal agents), Anticoagulant and anti platelet drugs.

Biochemical approaches in drug designing wherever applicable should be discussed.

SEVENTH SEMESTER PHR475 PHARMACEUTICAL JURISPRUDENCE B.PHARM.III :

THEORY: 4 hrs/week Marks: 100

1. Introduction:

a) Evolution of drugs, Pharmacy, Pharmaceutical Industry

b) Drug legislation in India

c) Overview of Pharmaceutical Education.

2. Elaborate study of

a) Pharmaceutical ethics

b) Pharmacy Act 1948.

c) Drugs and Cosmetics Act 1940 and Rules 1945.

d) Medicinal and Toilet preparations (Excise Duties) Act 1955.

e) Essential Commodities Act and price Control order.

f) Narcotic and psychotropic substances Act 1985 and Rules.

3. Brief study of:

a) Dangerous Drugs Acts and Rules.

b) Drugs and Magic Remedies ( Objectionable Advertisement) Act 1954.

c) Poisons Act 1919 and Rules.

d) State shops and Establishment Act and Rules.

a) Patents Act 1968. As amended bill 1998 rules.

f) Factories Act 1948.

g) Air Act,1988

h) Medical Termination of Pregnancy Act 1970 and Rules 1975.

I) Prevention of Cruelty to Animals Act 1960.

j) Water Act 1968.

k) Solid waste management act

4. A brief study of various Prescription/Non-prescription products, Medical/ Surgical Accessories,

Diagnostic aids. appliances available in market.

EIGHTH SEMESTER PHR 481. PHARMACEUTICAL ANALYSIS III

B. PHARM. IV Theory 4 hrs./week

Marks :100

A. Quality Assurance: ( A+ B) 20 hrs

1. GLP, ISO 9000, TOM, Quality Review and Quality Documentation.

2. Regulatory control, regulatory drug analysis, interpretation of analytical data.

3. Validation, quality audit: Quality of equipment, validation of equipment, validation of

analytical procedures.

B. Theoretical aspects, basic instrumentations and applications of the following chromatographic

techniques should be discussed - HPLC and GC

C. Theoretical aspects, basic instrumentations, elements of spectra and applications of the following

analytical techniques should be discussed ( C) 20 hrs

c.1. UV Visible

c.2 Infra Red Spectroscopy

c.1 Fluorimetery

c 2 Flame Photometry and Atomic Absorption Spectroscopy

c.3 Emission Spectroscopy

c.4 Nuclear Magnetic resonance spectroscopy including 13c NMR.

c 5. Mass Spectrometry


1. Quantitative estimation of at least ten formulations containing single drug or more than one drug, using

instrumental techniques.

2. Estimation of Na+, K+, Ca++ ions using flame photometry

3. IR of samples with different functional groups (-COOH, -COOR, -CQNHR -NH2, NHR, -OH, etc.)

4. Workshop to interpret the structure of simple organic compounds using UV, IR, NMR and MS.

EIGHTH SEMESTER PHR 482. MEDICINAL CHEMISTRY - IV

B. PHARM. IV

Theory 4 hrs./week Marks: 100

1. Drug metabolism and Concepts of Prodrugs.

2. Synthetic procedures of selected drugs, mode of action, uses, structure activity relationship (including

physicochemical aspects) of the following classes of drugs. (Biochemical approaches in drug designing

wherever applicable should be discussed).

i) Antimetabolites (including sulfonamides).

ii) Chemotherapeutic agents used in Protozoal, Parasitic and other infections.

iii) Antineoplastic agents

iv) Anti-viral including anti-HIV agents.

v) Immunosuppressives and immunostimulants.

3. Principles of Drug Design (Theoretical Aspects) Traditional analog (QSAR) and mechanism based

approaches (Introduction to graph theory), applications of quantum mechanics, Computer aided drug

designing (CADD) and molecular modeling.

Practicals 6 hrs./week Marks : 100

1. Exercises based on QSAR: Hansch & Free-Wilson methods.

2. Synthesis of selected drugs from the course content involving two or more steps and their spectral

analysis.

3. Establishing the Pharmacaopoelal standards of the drugs synthesized.

EIGHTH SEMETER PHR 483. PHARMACEUTICS-VIl

B.PHARM. IV (Formulation Design & Development) Theory 4 hrs./week

Marks 100

1. Pre-formulation studies; Detailed study of the following pre-formulation parameters;

(a) Physical properties of drugs like physical form, particle size, shape, density, wetting solutiblity, dielectric

constant, dissolution and organoleptic properties.

(b) Chemical properties of drugs-hydrolysis, oxidation, reduction, racemization, polymerization etc. and their

influence on the stability.

(c) Study of prodrugs, complexex and conjugates of drugs in solving problems related to stability, bio-

availability andelegance of the products.

2. Design, development and process validation for pharmaceutical operations involved in the production of

solid and liquid dosage forms.

3. Stability testing protocols and procedure as per ICH guidelines 4. Performance evaluation methods for pharmaceutici products:

(a) In-Vivo dissolution studies- Methods and interpretation of results.

(b) Bio-availability studies-protocols and procedures. Result Interpretations.

(c) In-Vivo studies-methods and statistical methods in the interpretation of results.

5. Introduction to Novel and controlled Drug Delivery Systems: (a) Implants and Inserts for

Opthalrnic, Intravaginal, Intrauterine, Subcutaneous administration.(b) liposomes, niosomes,

erythrosomes (c) micro-emulsions and multiple emulsion. Practicals 3 hrs./week

Marks ; 50

Experiments devised to study the preformulation of dosage forms, stability testing, formulation of dosage

forms, avaluation of dosage forms, evaluation of dosage form necessities in the stable formualtion of dosage

forms, process validation dissolution and bioavaialbility testing, and others to illustrate the topics mentioned

in theory. Preparation and evaluation of selected NDDS products.

EIGHT SEMESTER PHR 484 NANO TECHNOLOGY AND NANO BIOTECHNOLOGY

B.PHARM IV

Theory 4 hrs/ week Marks: 100

1. Introduction , definition and scope classification

2. Applications of Nanotechnology in Drug Discovery

2.1 A Historical Overview of the Drug Discovery Process

2.2 An Introduction to Nanotechnology in Drug Discovery and Development

2.3 Fundamentals of Nano-enabled Drug Discovery Tools : Atomic Force

Microscopy ,(AFM) and the Congruent Force Intermolecular Test, Field-Ion

Microscope , Near -field Scanning Optical Microscope (SNOM or NSOM) ,

Surface Plasmon Resonance , Nano-Mass Spectroscopy , Dip-Pen

Nanolithography (DPN)

2.4 Microarrays and Nanoarrays

2.5 Microfluidics and Nanofluidics

2.6 Nanoparticles for Drug Discovery :Quantum Dots (QDots) and Gold

Nanoparticles for High-Content and Initial Drug Screening , Nanoshells for

Raman Spectroscopy , Nanobarcode Particles

2.7 Nanomaterial Drugs : Abraxane , RenaZorb , Antimicrobial Emulsions ,

Antioxidant and Anti-HIV Fullerenes

2.8 Future Developments

3. Nano Technology in Drug Delivery

3.1 Nano Particles :- Definitions, classifications,

3.2 Polymeric nanoparticle:- Types, synthesis, purification, characterization,

property, bio degradation.

3.3 Lipid nanoparticles : Types, preparation, purification, characterization,

properties, bio degradation

3.4. Hydrogel Nanoparticles:- Synthesis & properties

3.5 Peptide nano particle:

3.6 Toxicity and toxicity evaluation of nanoparticles .

PHARMACY DEPARTMENT






Examination

T

P

Pap

er

Dura

-

tion

P&T

M

TW/

Pr

Viva

Total

Mark

s






ME 115 Engg Drawing

Total

4

4

4

3

3

-

3

3

1

1

1

-

3

3

3

3

100

100

100

-

50

50

-

50

50

150

150

100

50

50

12 9 300 150/

200

450/

500






AM 125 Mathematics

Total

4

4

4

4

4

3

3

3

3

-

1

1

1

1

1

3

3

3

3

3

100

100

100

100

100

50

50

50

50

-

150

150

150

150

100

20

12

500

200

700

PHARMACY DEPARTMENT






Examination CreditsCredits

T

P

Pap

er

Dura-

tion

P&

TM

TW/

Pr

Viva

Total

Mark

s





OR


ME 115 Engg Drawing

Total

4

4

4

4

3

3

-

3

3

1

1

1

1

-

3

3

3

3

3

100

100

100

100

-

50

50

-

50

50

150

150

100

50

8

8

4

2

2

12 9/

12

300 200/

150

450/

400

22/24






AM 125 Mathematics

Total

4

4

4

4

4

3

3

3

3

-

1

1

1

1

1

3

3

3

3

3

100

100

100

100

100

50

50

50

50

-

150

150

150

150

100

8

8

8

8

4

20 12 500 200 700 36






ChE235 Pharm.Engg-I

Total

4

4

4

4

4

3

3

-

3

-

1

1

1

1

1

3

3

3

3

3

100

100

100

100

100

50

50

-

50

-

150

150

100

150

100

8

8

4

8

4

20 9 500 150 650 32







Total

4

4

4

4

4

3

3

3

3

-

1

1

1

1

1

3

3

3

3

3

100

100

100

100

100

50

50

50

50

-

150

150

150

150

100

8

8

8

8

4

20 12

500 200 700 36


PHR351 Pharmaceutics-III(Hospi.Ph)





Total

4

4

4

4

4

-

6

3

4

-

1

1

1

1

1

3

3

3

3

3

100

100

100

100

100

-

100

50

50

-

100

200

150

150

100

4

12

8

8

4

20 13 500 200 700 36







Total

4

4

4

4

4

3

3

3

-

3

1

1

1

1

1

3

3

3

3

3

100

100

100

100

100

50

50

50

-

50

150

150

150

100

150

8

8

8

4

8

20 12

500 200 700 36

`







Total

Total

4

4

4

4

4

6

3

3

-

-

1

1

1

1

1

3

3

3

3

3

100

100

100

100

100

100

50

50

-

-

200

150

150

100

100

12

8

8

4

4

16 12 500 200 700 36






& Nanobiotechnology


Total

4

4

4

4

-

6

6

3

-

-

1

1

1

1

-

3

3

3

3

-

100

100

100

100

-

100

100

50

-

50

200

200

150

100

50

12

12

8

4

2

16 15 400 300 700 38


Examination CreditsCredits

T

P

Pap

er

Dura-

tion

P&

TM

TW/

Pr

Viva

Total

Mark

s





OR


ME 115 Engg Drawing

Total

4

4

4

4

3

3

-

3

3

1

1

1

1

-

3

3

3

3

3

100

100

100

100

-

50

50

-

50

50

150

150

100

50

10

10

4

6

6

12 9/

12

300 200/

150

450/

400

30/36






AM 125 Mathematics

Total

4

4

4

4

4

3

3

3

3

-

1

1

1

1

1

3

3

3

3

3

100

100

100

100

100

50

50

50

50

-

150

150

150

150

100

10

10

10

10

4

20 12 500 200 700 34






ChE235 Pharm.Engg-I

Total

4

4

4

4

4

3

3

-

3

-

1

1

1

1

1

3

3

3

3

3

100

100

100

100

100

50

50

-

50

-

150

150

100

150

100

10

10

4

10

4

20 9 500 150 650 38







Total

4

4

4

4

4

3

3

3

3

-

1

1

1

1

1

3

3

3

3

3

100

100

100

100

100

50

50

50

50

-

150

150

150

150

100

10

10

10

10

4

20 12

500 200 700 34


PHR351 Pharmaceutics-III(Hospi.Ph)





Total

4

4

4

4

4

-

6

3

4

-

1

1

1

1

1

3

3

3

3

3

100

100

100

100

100

-

100

50

50

-

100

200

150

150

100

4

12

10

10

4

20 13 500 200 700 40







Total

4

4

4

4

4

3

3

3

-

3

1

1

1

1

1

3

3

3

3

3

100

100

100

100

100

50

50

50

-

50

150

150

150

100

150

10

10

10

4

10

20 12

500 200 700 44







Total

Total

4

4

4

4

4

6

3

3

-

-

1

1

1

1

1

3

3

3

3

3

100

100

100

100

100

100

50

50

-

-

200

150

150

100

100

12

10

10

4

4

16 12 500 200 700 40






& Nanobiotechnology


Total

4

4

4

4

-

6

6

3

-

-

1

1

1

1

-

3

3

3

3

-

100

100

100

100

-

100

100

50

-

50

200

200

150

100

50

12

12

10

4

6

16 15 400 300 700 44

(old syllabus) pharmacy department faculty of …

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