of plants and men

Editorial Of plants and men Much attention is currently focused on the scien- tific, ethical, and political implications of the draft sequence of the human genome. In line with this, the next issue of CFG will carry pieces from two researchers in the field of human genetics/genomics on the impact that the draft sequence will have on their research. Andrew Simpson (Ludwig Institute, Sao Paulo, Brazil) will review the importance of ESTs after the release of both the draft sequence and the first estimate of the number of human genes based on hard data. There will also be an interview with Duncan Campbell on the changing role of the UK Medical Research Council’s Human Genome Mapping Project Resource Centre in Hinxton, now that the human genome sequence has been released. In contrast to the rather acrimonious relation- ships between some of the principal centres involved in sequencing the human genome, the Arabidopsis Genome Project was a highly collaborative world- wide effort and the subsequent phase of functional genomics looks like continuing in the same vein. In this issue of CFG, we have Arabidopsis as our ‘featured organism’. The article includes comments from Pam Green (Arabidopsis Functional Genomics Consortium and Michigan University, USA) and Sean May (Nottingham Arabidopsis Stock Centre, UK). We also have an interview with Mike Bevan (John Innes Centre, UK), who led the European sequencing effort. A number of funding bodies across the world are sponsoring the functional genomic analysis of the humble thale cress. The US has its 2010 program to determine the function of all Arabidopsis genes by that date. The European Union has established EXOTIC (EXOn Trapping Insert Consortium) and REGIA (REgulatory Gene Initiative in Arabidopsis) to investigate Arabidopsis gene expression patterns and transcription factors, respectively. In the UK, the BBSRC (Biotechnology & Biological Sciences Research Council) is sponsoring Arabidopsis functional analysis through its ‘Investigating Gene Function’ initiative. In all this excitement about multicellular organ- isms, we should not forget my favourite beasts – the yeasts. The next issue of CFG will feature the fission yeast Schizosaccharomyces pombe, one of the major models for the study of the eukaryotic cell cycle, whose genome has just been sequenced by a Sanger Centre/EU consortium. The current issue of CFG includes an article on the complete sequence of the mitochondrial genome of Yarrowia lipolytica – the hydrocarbon-utilising yeast that has been commer- cially exploited in the production of citric acid, as well as being an important model for the study of protein secretion. Steve Oliver Comparative and Functional Genomics Comp Funct Genom 2001; 2: 59. DOI: 10.1002/cfg.77 Copyright # 2001 John Wiley & Sons, Ltd.

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Editorial

Of plants and men

Much attention is currently focused on the scien-

tific, ethical, and political implications of the draft

sequence of the human genome. In line with this,

the next issue of CFG will carry pieces from two

researchers in the field of human genetics/genomics

on the impact that the draft sequence will have on

their research. Andrew Simpson (Ludwig Institute,

Sao Paulo, Brazil) will review the importance of

ESTs after the release of both the draft sequence

and the first estimate of the number of human

genes based on hard data. There will also be an

interview with Duncan Campbell on the changing

role of the UK Medical Research Council’s Human

Genome Mapping Project Resource Centre in

Hinxton, now that the human genome sequence

has been released.In contrast to the rather acrimonious relation-

ships between some of the principal centres involved

in sequencing the human genome, the Arabidopsis

Genome Project was a highly collaborative world-

wide effort and the subsequent phase of functional

genomics looks like continuing in the same vein. In

this issue of CFG, we have Arabidopsis as our

‘featured organism’. The article includes comments

from Pam Green (Arabidopsis Functional Genomics

Consortium and Michigan University, USA) and

Sean May (Nottingham Arabidopsis Stock Centre,

UK). We also have an interview with Mike Bevan

(John Innes Centre, UK), who led the Europeansequencing effort. A number of funding bodiesacross the world are sponsoring the functionalgenomic analysis of the humble thale cress. TheUS has its 2010 program to determine the functionof all Arabidopsis genes by that date. The EuropeanUnion has established EXOTIC (EXOn TrappingInsert Consortium) and REGIA (REgulatory GeneInitiative in Arabidopsis) to investigate Arabidopsisgene expression patterns and transcription factors,respectively. In the UK, the BBSRC (Biotechnology& Biological Sciences Research Council) is sponsor-ing Arabidopsis functional analysis through its‘Investigating Gene Function’ initiative.

In all this excitement about multicellular organ-isms, we should not forget my favourite beasts – theyeasts. The next issue of CFG will feature the fissionyeast Schizosaccharomyces pombe, one of the majormodels for the study of the eukaryotic cell cycle,whose genome has just been sequenced by a SangerCentre/EU consortium. The current issue of CFGincludes an article on the complete sequence of themitochondrial genome of Yarrowia lipolytica – thehydrocarbon-utilising yeast that has been commer-cially exploited in the production of citric acid, aswell as being an important model for the study ofprotein secretion.

Steve Oliver

Comparative and Functional GenomicsComp Funct Genom 2001; 2: 59.DOI: 10.1002/cfg.77

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