April – May 2017ReseaRch Bulletin

Katherine Vig, BDs, Ms, DOrth, Receives Honors of the Association Award from the american cleft Palate-craniofacial association

Dr. Katherine Vig, senior lecturer in the Department of Developmental Biology at HSDM, received the Honors of the Association Award from the american cleft Palate-craniofacial association.

Vig’s vast research and clinical career, compiled in peer-reviewed journal articles, commentaries, discussions, books, and lectures, has established her reputation as an expert in the orthodontic management of craniofacial anomalies as well as in the topics of alveolar bone grafting, orthognathic surgery, treatment satisfaction, quality of life, and evidence-based practice. Vig currently serves as a reviewer for the American Journal of Orthodontics, Cleft-Palate-Craniofacial Journal, and the British Journal of Orthodontics. Vig has published over 100 scientific articles and has co-authored three textbooks.

The ACPA Honors of the Association Award represents the ACPA highest expression of respect and gratitude ACPA bestows. It is granted to an individual whose lifetime of research, health care delivery or leadership has advanced, significantly and uniquely, the amelioration of physical, behavioral or social handicapping conditions of cleft lip and palate or other craniofacial anomalies.

nisarg Patel, Receives aDa Dentsply /sirona awardNisarg Patel, an HSDM student in the DMD class of 2018, received this year’s Student Clinician Research Program Award from the American Dental Association (ADA) Densply/Sirona Program. This Program was first presented in 1959 at the centennial session of the ADA in New York City

as a joint venture between then DENTSPLY International and the ADA. Patel is founder and CEO of Memora Health, a digital health company building natural language processing technology to provide patients with care support and health monitoring at home. Prior to enrolling at HSDM, Nisarag was a synthetic biologist at the Wyss Institute and Arizona State University researching cancer immunotherapy, infectious disease diagnostics, and CRISPR/Cas9 mediated genome editing.

DMD class of 2017 students Receive honors in Research

cherry choyCaregivers’ perspectives on preschool children’s beverage consumption behaviors and influences Mentor, Dr. Inyang Isong

Jason OutlawCaries free communities: The development of site selection criteria Mentor, Dr. Saska Estupinan Day

Joseph DePaloAssessing the relationship between oral chronic graft-versus-host disease and global measures of quality of life Mentor, Dr. Nathaniel Treister

James BakerOpioid prescribing after surgical extraction of teeth in medicaid patients, 2000-2010 Mentor, Dr. Brian Bateman

sara tejaniCandidal carriage predicts candidiasis during topical immunosuppressive therapy: A preliminary retrospective cohort study Mentor, Dr. Sook-Bin Woo

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2 Research Bulletin • April–May 2017 • Harvard School of Dental Medicine

andreia ionescu, PhD, Receives Eleanor and Miles Shore 50th Anniversary Fellowship Program Award

Dr. Andreia Ionescu, Assistant Professor in the Department of Developmental Biology at HSDM, received an Eleanor and Miles Shore 50th Anniversary Fellowship Award in honor of Aina M. Auskaps, DMD. This Award will help support her project, “ Isolation and characterization of a chondrocyte progenitor population with relevance to Osteoarthritis.”

Ionescu received a BS degree in Physics from University of Bucharest, Romania followed by a PhD degree in Biochemistry and Biophysics from the University of Rochester Medical School, NY. In 2003, Ionescu joined Dr. Andrew Lassar’s lab at Harvard Medical School as a postdoctoral fellow, where she discovered a new family of transcription factors (FoxA) that plays a crucial role in both cartilage development and osteoarthritis. In 2012, Ionescu was awarded a 2-year grant from the Arthritis National Research Foundation (ANRF) to investigate whether loss of FoxA expression in articular cartilage can protect the knee joint articular cartilage against osteoarthritic degradation. This research has received two prizes for excellence, the Frances D. Morongo award (2012) and the Jack and Vonnie Schlomer award (2013) from the ANRF. Ionescu joined the faculty in the Department of Developmental Biology at Harvard School of Dental Medicine in 2014.

The purpose of the Shore Fellowship Program is to enhance the quality and diversity of the Faculty of Medicine at all ranks. Stipends are offered to junior faculty at the most critical point in their academic careers.

erica shapiro-Frenkel Graduates with PhD from BsDM Program

erica shapiro-Frenkel, PhD, DMD 2019 candidate, will graduate this May with a PhD degree in Biological Sciences in Dental Medicine. Shapiro completed her PhD thesis work, “The role of MUC5B salivary mucin in modulating oral bacterial surface colonization and interspecies competition” under the mentorship of

Katharina Ribbeck professor of Tissue Engineering in the Department of Biological Engineering at Massachusetts Institute of Technology. Shapiro-Frenkel stated, “I am looking forward to rejoining the Class of 2019 and gaining more clincial experience. Utlimately, I would like to combine my interests in dentistry and research. I would like to investigate the scientific and clinical aspects of dentistry, pinpointing limiting factors in dental practice and developing solutions in the laboratory.”

DMD honors in Research (cont.)

Karan GanjawallaUpper airway length is predictive of sleep apnea in syndromic craniosynostosis Mentor, Dr. Bonnie Padwa

Patrick VaughnGlobal patterns of QALY and DALY use in surgical cost-utility analyses: A systematic review Mentor, Dr. Edward Caterson

Research Bulletin • April–May 2017 • Harvard School of Dental Medicine 3

hsDM Publications DeVelOPMental BiOlOGy

Fields H, Kim D, Jeon M, Firestone A, Sun Z, Shanker S, Mercado A, Deguchi T, Vig K. Evaluation of objective structured clinical examination for advanced orthodontic education 12 years after introduction. American Journal of Orthodontics and Dentofacial Orthopedics 2017; 151(5):840-850.

Li Z, Hao J, Duan X, Wu N, Zhou Z, Yang F, Li J, Zhao Z, Huang S. The role of semaphorin 3A in bone remodeling. Frontiers in Cellular Neuroscience 2017; 11:40.

Lin J, Allareddy V, Ross E, Shusterman S. A comparison of mixed dentition dental development in cleft patients treated with and without the latham-type appliance. Pediatric Dentistry 2017; 39(1):53-58.

Lowery J, Rosen V. Bone morphogenetic protein-based therapeutic approaches. Cold Spring Harbor Perspectives in Biology 2017; Apr 7.

Marroquin T, Karkhanis S, Kvaal S, Vasudavan S, Kruger E, Tennant M. Age estimation in adults by dental imaging assessment systematic review. Forensic Science International 2017; 275:203-211.

ORal health POlicy anD ePiDeMiOlOGy

Burke S, Maramaldi P. The Social Security Administration’s Compassionate Allowances Initiative: Condition spotlight on Rubinstein-Taybi syndrome. Health Social Work 2017; 42(1):e32-e43.

Heaton B, Crawford A, Garcia R, Henshaw M, Riedy C, Barker J, Wimsatt M. Oral health beliefs, knowledge, and behaviors in Northern California American Indian and Alaska Native mothers regarding early childhood caries. Journal of Public Health Dentistry 2017; Apr 27.

Lee K, Rondeau V, Haneuse S. Accelerated failure time models for semi-competing risks data in the presence of complex censoring. Biometrics 2017; Apr 10.

ORal MeDicine, inFectiOn anD iMMunity

Hruska K, Lanske B, Moe O. Crosstalk between kidney and bone - bench to bedside. Bone 2017; Apr 11.

Kim D, Garon E, Jatoi A, Keefe D, Lacouture M, Sonis S, Gernhardt D, Wang T, Giri N, Doherty J, Nadanaciva S, O’Connell J, Sbar E, Cho B. Impact of a planned dose interruption of dacomitinib in the treatment of advanced non-small-cell lung cancer (ARCHER 1042). Lung Cancer 2017; 106:76-82.

Komaba H, Kaludjerovic J, Hu D, Nagano K, Amano K, Ide N, Sato T, Densmore M, Hanai J, Olauson H, Bellido T, Larsson T, Baron R, Lanske B. Klotho expression in osteocytes regulates bone metabolism and controls bone formation. Kidney International 2017; Apr 8.

Lanske B, Rosen C. Bone marrow adipose tissue: The first 40 years. Journal of Bone and Mineral Research 2017; Mar 31.

Sato T, Courbebaisse M, Ide N, Fan Y, Hanai J, Kaludjerovic J, Densmore M, Yuan Q, Toka H, Pollak M, Hou J, Lanske B.Parathyroid hormone controls paracellular Ca2+ transport in the thick ascending limb by regulating the tight-junction protein Claudin14. Proceedings of the National Academy of Science USA 2017; Apr 3.

Sonis S. The chicken or the egg? Changes in oral microbiota as cause or consequence of mucositis during radiation therapy. EBioMedicine 2017;18:7-8.

Stojanov I, Malik U, Woo SB. Intraoral salivary duct cyst: Clinical and histopathologic features of 177 cases. Head and Neck Pathology 2017; Mar 27.

Thomas S, Izard J, Walsh E, Batich K, Chongsathidkiet P, Clarke G, Sela D, Muller A, Mullin J, Albert K, Gilligan J, DiGuilio K, Dilbarova R, Alexander W, Prendergast G. The host microbiome regulates and maintains human health: A primer and perspective for non-microbiologists. Cancer Research 2017; Mar 14.

Wilk K, Yeh S, Mortensen L, Ghaffarigarakani S, Lombardo C, Bassir S, Aldawood Z, Lin C, Intini G. Postnatal calvarial skeletal stem cells expressing PRX1 reside exclusively in the calvarial sutures and are required for bone regeneration. Stem Cell Reports 2017; Mar 30.

ORal anD MaxillOFacial suRGeRy

Chouinard A, Peacock Z, Faquin W, Kaban L. Unicystic ameloblastoma revisited: Comparison of Massachusetts General Hospital outcomes with original Robinson and Martinez Report.Journal of Oral and Maxillofacial Surgery 2017; Mar.

Padwa B, Dang R, Resnick C. Surgical uprighting is a successful procedure for management of impacted mandibular second molars. Journal of Oral and Maxillofacial Surgery 2017; Mar.

RestORatiVe DentistRy anD BiOMateRials sciences

Finelle G, Lee S. Guided immediate implant placement with would closure by computer-aided design/computer-assisted manufacture sealing socket abutment: Case report. International Journal of Oral and Maxillofacial Implants 2017; 32(2):e63-e67.

Lee S, Lee J. Digital impressions for implant-supported fixed dental prostheses. Current Oral Health Reports 2017.

Nalliah R, Budd A, Allareddy V. Pilot survey of the health of Massachusetts dentists. Journal of Investigative Clinical Dentistry 2017; Apr 16.

Multi-DePaRtMental

Ba Z, Pan F, Liu Z, Yu B, Fuentes L, Wu D, Zhu J. Percutaneous endoscopical transforaminal approach versus PLF to treat the single-level adjacent segment disease after PLF/PLIF: 1-2 years follow-up. International Journal of Surgery 2017; Apr 17.

Giddon D, Donoff RB, Edwards P, Goldblatt L. Should dental schools train dentists to routinely provide limited preventive primary medical care? Two viewpoints: Viewpoint 1: Dentists should be trained to routinely provide limited preventive primary care and Viewpoint 2: Dentists should be trained in primary care medicine to enable comprehensive patient management within their scope of practice. Journal of Dental Education 2017; 81:561-570.

Patel N, Ji Y, Dodson T, Donoff RB. Health policy research may ensure the future of oral and maxillofacial surgery. Journal of Oral and Maxillofacial Surgery 2017; Mar.

4 Research Bulletin • April–May 2017 • Harvard School of Dental Medicine

a publication of the Office of Research188 Longwood Avenue — Boston, MA 02115

www.hsdm.harvard.edu

Bjorn R. Olsen, MD, PhD, Dean for ResearchDawn M. DeCosta, Editor and Layout

Heather M. Denny, EditingLeanne Jacobellis, Editing

Lia Sgourakes, Editing

For information regarding the Research Bulletin, please contact Dawn DeCosta at dawn_decosta@hsdm.harvard.edu, or 617.432.1121.

2017 Research Day Poster awards POstDOctORal FellOW cateGORysanjoy Khan, PhD, Postdoctoral Fellow Expression of GαsR201H in mesenchymal progenitor cells causes fibrous dysplasia in mice Mentor, Dr. Yingzi Yang DMsc stuDent cateGORyalaa ahmed, DDs, (DMsc Periodontology, 2017) The impact of hyperglycemia on human neutrophil functionMentor, Dr. Thomas Van Dyke Karim el Kholy, DDs, (DMsc implant Dentistry, 2017)Investigating the role of resolvin E1 in bone remodelingMentor, Dr. Thomas Van Dyke MMsc stuDent cateGORysara shah, DMD, (MMsc Periodontology, 2017)The use of extra-short dental implants for the rehabilitation of missing teeth: A randomized controlled clinical trialMentor, Dr. Eli Machtei afsaneh shahrokhi Rad, DMD, (MMsc Prosthodontics, 2017)A novel multifunctional polymeric membrane for periodontal tissue engineering Mentor, Dr. Ali Khademhosseini DMD stuDent cateGORyJoseph DePalo, (DMD, 2017)Assessing the relationship between oral chronic graft-versus-host disease and global measures of quality of life Mentor, Dr. Nathaniel Treister Jonathan Foster, (DMD, 2017) Computational identification and segmentation of the PDL collagen networks Mentor, Dr. Gili Naveh alexander hahn, (DMD, 2017) Conformational dynamics of antibodies via in silico simulations Mentor, Dr. Piotrek Sliz

hend alqaderi, BDs, DMsc, Receives Leverett Award

Dr. Hend Alqaderi, lecturere in Oral Health Policy and Epidemiology, received the Leverett Graduate Student Merit Award by the American Association of Public Health Dentistry for Outstanding Achievement in Dental Public Health. She

was presented with the award at the National Oral Health Conference at Albuquerque, New Mexico in April 2017.

Alqaderi has a Bachelor of Dental Surgery degree from the Faculty of Dentistry in Alexandria University, Egypt. She completed an Advanced General Dentistry Fellowship at the Royal College of Surgeon in Ireland in 2008. In 2016, Alqaderi received a DMSc and a Certificate in Dental Public Health from HSDM.