nuclear pharmacy lab #1
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DANGER Radiation risk. DANGER Radiation risk. Nuclear Pharmacy Lab #1. DANGER Radiation risk. DANGER Radiation risk. What is Nuclear Pharmacy?. - PowerPoint PPT PresentationTRANSCRIPT
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Nuclear Pharmacy
Lab #1
DANGERRadiation
risk
DANGERRadiation
risk
DANGERRadiation
risk
DANGERRadiation
risk 43
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WHAT IS NUCLEAR PHARMACY?
The development of nuclear pharmacy as a specialty area followed the development of nuclear medicine as a recognized specialty by the American Medical Association in the early 1970's.
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WHAT IS NUCLEAR PHARMACY?
Nuclear Medicine
A specialty of medicine and medical imaging that uses radiopharmaceuticals in the diagnosis and treatment of diseases.
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WHAT IS NUCLEAR PHARMACY?
Nuclear Pharmacy
A specialty area of pharmacy practice dedicated to the compounding and dispensing radiopharmaceuticals for use in nuclear medicine procedures.
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WHAT ARE THE APPLICATIONS OF RADIOPHARMACY?
1. Diagnostic
The radiopharmaceutical accumulated in an
organ of interest emit gamma radiation which
are used for imaging of the organs with the
help of an external imaging device called
gamma camera.
2. Treatment
They are radiolabeled molecules designed to
deliver therapeutic doses of ionizing radiation
to specific diseased sites.
3. ResearchKing Saud University 6
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THE NUCLEAR PHARMACIST ROLE
1. Order, receipt, storage and inventory control of radioactive drugs (radiopharmaceuticals)
2. Preparation of radiopharmaceuticals
3. Functional checks of instruments
4. Determination of radiopharmaceutical quality and purity
5. Filling of prescription orders
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THE NUCLEAR PHARMACIST ROLE 6. Packaging, labeling of radiopharmaceuticals
7. Communicating radiopharmaceutical-related information to others
8. Assuring that patients receive proper preparation
9. Participation in clinical trials
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EMPLOYMENT OPPORTUNITIES
Nuclear Pharmacists work in a wide variety of settings:
1. Nuclear pharmacies 2. Hospitals 3. Academia 4. Industry 5. Government and private research institutes
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TRAINING Nuclear pharmacists can receive training by attending a
nuclear pharmacy program in various schools of pharmacy and practice experience through a nuclear pharmacy. The colleges listed below offer nuclear pharmacy programs
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University of Arkansas Mercer University University of Oklahoma
Butler University University of New Mexico Purdue University
Duquesne University State University of New York at Buffalo
Medical University of South Carolina
Massachusetts College of Pharmacy
Ohio State University Temple University
University of Utah
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CERTIFICATION
Upon successful completion of a nuclear pharmacist training program, nuclear pharmacists can be certified through an examination offered by the Board of Pharmaceutical Specialties (BPS).
Such nuclear pharmacists are then designated as Board Certified Nuclear Pharmacists (BCNP). For more information
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DESIGN OF A NUCLEAR PHARMACY
Protection of personnel from radiation hazard.Control of personnel radiation exposure is
performed with approved personal dosimeters, which are regularly checked and their readings recorded.
Avoidance of contamination of work area. Radiation detection instruments. Clean air. Disposal of radioactive waste.
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Dispensing Area
Counting Lab
Compounding Area
Offices
Corridor
Conceptual design of a nuclear pharmacy unit
Should be equipped with workbenches made of stainless steel or wood covered with laminated plastic
The floor should be made of removable tiles or covered with rubber matting so it can be replaced with new ones in case of spillage
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OPERATION OF A NUCLEAR PHARMACY
1. Receiving of radioactive materials
2. Preparation of radiopharmaceuticals
3. Quality control tests of radiopharmaceuticals
4. Storage
5. Dispensing
6. Radioactive waste disposal
7. Infectious waste disposal
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RECEIVING RADIOACTIVE MATERIALS
Delivered directly to nuclear medicine department or nuclear pharmacy (short half-lives)
Packages should be monitored within 3 hr if delivered during normal hours
Packages should be monitored within 3 hr from the beginning of the next working day if delivered after working hours
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PREPARATION OF RADIOPHARMACEUTICALS
Only trained people should be responsible for and participate in the preparation
Aseptic technique Lead barrier shields Syringe shields Leaded gloves, aprons, and eye
glasses should be worn Quantity
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RADIATION SHIELDING Alpha and beta radiations are readily shielded because of
their limited range of penetration.
Radiation Protection
Alpha particles Piece of paper •Mono-energetic and have a range of a few centimeters in air
Beta radiation •Aluminum•Glass•Transparent plastic materials
Gamma radiation •Lead•Tungsten
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QUALITY CONTROL TESTS OF RADIOPHARMACEUTICALS
Before despising for humans Colloidal and macro-aggregated preparation
should be checked for particle size. Workstations and their environment should
regularly be monitored with respect to microbiological quality.
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STORAGE
Should be properly stored to prevent degradation by light or temperature
Must be stored in lead containers or behind lead shields
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DISPENSING
Starts with a prescription Prescription should contain
1. Patients name
2. Identification no.
3. Age
4. Date time
5. Physician signature
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RADIOACTIVE WASTE DISPOSAL
Syringes, vials containing residual activities, needles, contaminated papers, liquid waste
According to guideline 1. Decay in storage
2. Release into a sewerage system
3. Transfer to an authorized recipient (disposable facility)
4. Others (incineration and atmospheric release of radioactive gases)
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RADIOACTIVE WASTE DISPOSAL
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• Radionuclides with have lives less than 120 days usually are disposed of by this method
• Radio active should be stored separately according the similar half lives
• For soluble radioactive materials in water• Disposed quantity should not exceed the limits of the
maximum permitted concentrations (MPCs)• Flow rate of water• Number of radionuclide
• For long-lived radionuclide• They bury or incinerate at approved sites and
facilities
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INFECTIOUS WASTE DISPOSAL
Body fluids tissue Incinerated or chemically treated,
steamed or dry sterilized Should be stored in puncture resistant,
leak resistant bags or containers Should be labeled with international
biohazard symbol Storage period
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THANK YOU Kin
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