ntp.niehs.nih.gov...tdms no. 20310 - 01 p09: non-neoplastic lesions by individual animal date report...

TDMS No. 20310 - 01 P09: NON-NEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Date Report Requested: 06/29/2009

Test Type: 26-39 WEEKS 3'-Azido-3'-deoxythymidine (AIDS) Time Report Requested: 16:30:29

Route: GAVAGE CAS Number: 30516-87-1 First Dose M/F: NA / 11/18/04

Species/Strain: MICE/C3B6F1-+/Trp53(tm1Brd) Lab: NCTR

C Number: C20310C

Lock Date: 12/01/2008

Cage Range: ALL

Date Range: ALL

Reasons For Removal: ALL

Removal Date Range: ALL

Treatment Groups: Include ALL

Study Gender: Female

TDMSE Version: 2.1.0

ALIMENTARY SYSTEM.........................................................................................................................................................................................................

Esophagus + M + + + + + + M + + + + + + + + + + + + M + + +Adventitia, Foreign Body XAdventitia, Necrosis 2

.........................................................................................................................................................................................................

Gallbladder + + + + + + + + + + + + + + + + M + + M + + + + +.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation, Chronic Active 1 1 1Tension Lipidosis 1Vacuolization Cytoplasmic 1

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +





DAY ON TEST0045

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.................................................................................................................................................................

C3B6F1-+/TRP53(TM1BRD) NCTRMICE FEMALE

ANIMAL IDVehicle 6 mo F

00173

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females(cont...)

* .. Total animals with tissue examined microscopically; Total animals with lesion and mean severity grade+ .. Tissue examined microscopically M .. Missing tissue 1-4 .. Lesion qualified as:x .. Lesion present A .. Autolysis precludes evaluation 1) Minimal 3) ModerateI .. Insufficient tissue BLANK .. Not examined microscopically 2) Mild 4) Marked

.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1 1 1 1 1 1 2 1 1 1 1 1 1 1

.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + + + +

CARDIOVASCULAR SYSTEM.........................................................................................................................................................................................................

Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + +Cardiomyopathy 1Pericardium, Inflammation, Chronic 3

ENDOCRINE SYSTEM.........................................................................................................................................................................................................

Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Accessory Adrenal Cortical Nodule XVacuolization Cytoplasmic 2 2Subcapsular, Hyperplasia 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +





DAY ON TEST0045

0230

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.................................................................................................................................................................



00173

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females(cont...)


.........................................................................................................................................................................................................

Parathyroid Gland + + + + + + + + + + + + + + M + + + + + + + + M MInfiltration Cellular, Lymphocyte 1

.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +Cyst 2Infiltration Cellular, Lymphocyte 2

GENERAL BODY SYSTEMNONE

GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + + M + + + + + + + + + + M + + + + + + + + + + +.........................................................................................................................................................................................................

Ovary + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + +Endometrium, Hyperplasia, Cystic 2Lumen, Dilatation 2 1

.........................................................................................................................................................................................................

Vagina + + + + + + + + + + + + + + + + + + + + + + + + +





DAY ON TEST0045

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00173

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females(cont...)


HEMATOPOIETIC SYSTEM.........................................................................................................................................................................................................

Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +Myeloid Cell, Hyperplasia 3 2 3

.........................................................................................................................................................................................................

Lymph Node + +Mediastinal, Hyperplasia, Lymphoid 4 4Mediastinal, Infiltration Cellular, Plasma

Cell 4

.........................................................................................................................................................................................................

Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, Lymphoid 1 2 1

.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + M + + + M + + +Hyperplasia, Lymphoid 1 2 2 1 2 1 2

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Depletion Lymphoid 3Hematopoietic Cell Proliferation 4 4 3

.........................................................................................................................................................................................................

Thymus + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, Lymphoid 2 2 3Hyperplasia, Plasma Cell 3Necrosis 3Adventitia, Inflammation, Chronic 4Epithelial Cell, Hyperplasia 1





DAY ON TEST0045

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00173

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females(cont...)


INTEGUMENTARY SYSTEM.........................................................................................................................................................................................................

Mammary Gland M + + + + + + + + + + + + + M + + + + + + + + + +.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + +

MUSCULOSKELETAL SYSTEM.........................................................................................................................................................................................................

Bone, Femur + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Skeletal Muscle + + + + + + + + + + + + + + + + + + + + + + + + +

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain, Brain Stem + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Brain, Cerebellum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Brain, Cerebrum + + + + + + + + + + + + + + + + + + + + + + + + +Cyst Epithelial Inclusion X

RESPIRATORY SYSTEM.........................................................................................................................................................................................................

Lung + + + + + + + + + + + + + + + + + + + + + + + + +





DAY ON TEST0045

0230

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.................................................................................................................................................................



00173

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females(cont...)


Abscess 4 4Infiltration Cellular, Lymphocyte 1Mediastinum, Necrosis 4

.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +

SPECIAL SENSES SYSTEM.........................................................................................................................................................................................................

Eye + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1 1 1 1 1 1 2 1Inflammation, Chronic Active 1

.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1 1 1





DAY ON TEST0045

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.................................................................................................................................................................



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females(cont...)



Esophagus + A 23Adventitia, Foreign Body 1Adventitia, Necrosis 1 2.0

.........................................................................................................................................................................................................

Gallbladder + A 24.........................................................................................................................................................................................................

Intestine Large, Cecum + A 26.........................................................................................................................................................................................................

Intestine Large, Colon + A 26.........................................................................................................................................................................................................

Intestine Large, Rectum + A 26.........................................................................................................................................................................................................

Intestine Small, Duodenum + A 26.........................................................................................................................................................................................................

Intestine Small, Ileum + A 26.........................................................................................................................................................................................................

Intestine Small, Jejunum + A 26.........................................................................................................................................................................................................

Liver + A 26Inflammation, Chronic Active 3 1.0Tension Lipidosis 1 1.0Vacuolization Cytoplasmic 1 1.0

.........................................................................................................................................................................................................

Pancreas + A 26





DAY ON TEST0206

0139

.................................................................................................................................................................



00443

00464 * TOTALS


.........................................................................................................................................................................................................

Salivary Glands + A 26Infiltration Cellular, Lymphocyte 14 1.1

.........................................................................................................................................................................................................

Stomach, Forestomach + A 26.........................................................................................................................................................................................................

Stomach, Glandular + A 26


Blood Vessel + A 26.........................................................................................................................................................................................................

Heart + A 26Cardiomyopathy 1 1.0Pericardium, Inflammation, Chronic 1 3.0


Adrenal Cortex + A 26Accessory Adrenal Cortical Nodule 1Vacuolization Cytoplasmic 2 2.0Subcapsular, Hyperplasia 23 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + A 26.........................................................................................................................................................................................................

Islets, Pancreatic + A 26





DAY ON TEST0206

0139

.................................................................................................................................................................



00443

00464 * TOTALS


.........................................................................................................................................................................................................

Parathyroid Gland M A 22Infiltration Cellular, Lymphocyte 1 1.0

.........................................................................................................................................................................................................

Pituitary Gland + A 26.........................................................................................................................................................................................................

Thyroid Gland + A 26Cyst 1 2.0Infiltration Cellular, Lymphocyte 1 2.0


GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + A 24.........................................................................................................................................................................................................

Ovary + A 26.........................................................................................................................................................................................................

Uterus + A 26Endometrium, Hyperplasia, Cystic 1 2.0Lumen, Dilatation 2 1.5

.........................................................................................................................................................................................................

Vagina + + 27





DAY ON TEST0206

0139

.................................................................................................................................................................



00443

00464 * TOTALS



Bone Marrow + A 26Myeloid Cell, Hyperplasia 3 2.7

.........................................................................................................................................................................................................

Lymph Node + 3Mediastinal, Hyperplasia, Lymphoid 2 4.0Mediastinal, Infiltration Cellular, Plasma

Cell1 4.0

.........................................................................................................................................................................................................

Lymph Node, Mandibular + A 26Hyperplasia, Lymphoid 3 1.3

.........................................................................................................................................................................................................

Lymph Node, Mesenteric + A 24Hyperplasia, Lymphoid 7 1.6

.........................................................................................................................................................................................................

Spleen + A 26Depletion Lymphoid 1 3.0Hematopoietic Cell Proliferation 3 3.7

.........................................................................................................................................................................................................

Thymus + A 26Hyperplasia, Lymphoid 3 2.3Hyperplasia, Plasma Cell 1 3.0Necrosis 1 3.0Adventitia, Inflammation, Chronic 1 4.0Epithelial Cell, Hyperplasia 1 1.0





DAY ON TEST0206

0139

.................................................................................................................................................................



00443

00464 * TOTALS



Mammary Gland + A 24.........................................................................................................................................................................................................

Skin + A 26


Bone, Femur + + 27.........................................................................................................................................................................................................

Skeletal Muscle + + 27

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain, Brain Stem + A 26.........................................................................................................................................................................................................

Brain, Cerebellum + A 26.........................................................................................................................................................................................................

Brain, Cerebrum + A 26Cyst Epithelial Inclusion 1


Lung + A 26





DAY ON TEST0206

0139

.................................................................................................................................................................



00443

00464 * TOTALS


Abscess 2 4.0Infiltration Cellular, Lymphocyte 1 1.0Mediastinum, Necrosis 1 4.0

.........................................................................................................................................................................................................

Nose + A 26.........................................................................................................................................................................................................

Trachea + A 26


Eye + A 26.........................................................................................................................................................................................................

Harderian Gland + A 26Infiltration Cellular, Lymphocyte 1 1.0

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + A 26Infiltration Cellular, Lymphocyte 8 1.1Inflammation, Chronic Active 1 1.0

.........................................................................................................................................................................................................

Urinary Bladder + A 26Infiltration Cellular, Lymphocyte 3 1.0





DAY ON TEST0206

0139

.................................................................................................................................................................



00443

00464 * TOTALS



Esophagus + + + M + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Gallbladder + + + + + + + + + + + + + + M + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, Lymphoid 2 2

.........................................................................................................................................................................................................






Liver + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 2Inflammation, Chronic Active 1 1Tension Lipidosis 2 2 2Vacuolization Cytoplasmic 1

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +





DAY ON TEST0227

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.................................................................................................................................................................


ANIMAL IDAZT 120 6 mo F

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females(cont...)


Infiltration Cellular, Lymphocyte 1Inflammation, Chronic Active 1

.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1 1 1 1 2 1 1

.........................................................................................................................................................................................................




Blood Vessel + + M + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + +Pericardium, Inflammation, Chronic Active 2Pericardium, Mineralization 3


Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Accessory Adrenal Cortical Nodule XSubcapsular, Hyperplasia 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................





DAY ON TEST0227

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females(cont...)


Islets, Pancreatic + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Parathyroid Gland + M + + + + + + + + + + + M + M + + + + M + + M +.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Thyroid Gland + M + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1

GENERAL BODY SYSTEM.........................................................................................................................................................................................................

Tissue NOS +Abscess 4

GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + + + + + + + + + + + + + + + + + + + + M + + + +.........................................................................................................................................................................................................

Ovary + + + + + + + + + + + + + + + + + + + + + + + + +Cyst 2

.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + +Endometrium, Hyperplasia, Cystic 1Lumen, Dilatation 2 1

.........................................................................................................................................................................................................

Vagina + + + + + + + + + + + + + + + + + + + + + + + + +





DAY ON TEST0227

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females(cont...)



Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +Myeloid Cell, Hyperplasia 2 4

.........................................................................................................................................................................................................

Lymph Node +.........................................................................................................................................................................................................

Lymph Node, Mandibular + + + + M + + + + + + + + + + + + + + + + + + + +Hyperplasia, Lymphoid 2 1

.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + M + + + + + + + + + + + + + + + + + +Hyperplasia, Lymphoid 1 1 1 2 1 1 2 1 2 2

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Hematopoietic Cell Proliferation 3 4Hyperplasia, Lymphoid 3 4

.........................................................................................................................................................................................................

Thymus + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, Lymphoid 2


Mammary Gland + + M + + + + + M + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + +





DAY ON TEST0227

0229

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00391

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00397

00398

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00438

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00502

females(cont...)



Bone, Femur + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Skeletal Muscle + + + + + + + + + + + + + + + + + + + + + + + + +

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain, Brain Stem + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................


Brain, Cerebrum + + + + + + + + + + + + + + + + + + + + + + + + +


Lung + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation, Chronic Active 2Mediastinum, Inflammation, Chronic Active 2Mediastinum, Mineralization 4

.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +





DAY ON TEST0227

0229

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00267

00286

00287

00391

00392

00397

00398

00437

00438

00440

00502

females(cont...)



Eye + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1 1 1

.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1





DAY ON TEST0227

0229

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00221

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00228

00229

00244

00245

00246

00247

00248

00258

00259

00260

00264

00267

00286

00287

00391

00392

00397

00398

00437

00438

00440

00502

females(cont...)



Esophagus + 25.........................................................................................................................................................................................................

Gallbladder + 25.........................................................................................................................................................................................................

Intestine Large, Cecum + 26Hyperplasia, Lymphoid 2 2.0

.........................................................................................................................................................................................................

Intestine Large, Colon + 26.........................................................................................................................................................................................................

Intestine Large, Rectum + 26.........................................................................................................................................................................................................

Intestine Small, Duodenum + 26.........................................................................................................................................................................................................

Intestine Small, Ileum + 26.........................................................................................................................................................................................................

Intestine Small, Jejunum + 26.........................................................................................................................................................................................................

Liver + 26Infiltration Cellular, Lymphocyte 1 2.0Inflammation, Chronic Active 2 1.0Tension Lipidosis 3 2.0Vacuolization Cytoplasmic 1 1.0

.........................................................................................................................................................................................................

Pancreas + 26





DAY ON TEST0229

.................................................................................................................................................................



00503 * TOTALS


Infiltration Cellular, Lymphocyte 1 1.0Inflammation, Chronic Active 1 1.0

.........................................................................................................................................................................................................

Salivary Glands + 26Infiltration Cellular, Lymphocyte 7 1.1

.........................................................................................................................................................................................................

Stomach, Forestomach + 26.........................................................................................................................................................................................................

Stomach, Glandular + 26


Blood Vessel + 25.........................................................................................................................................................................................................

Heart + 26Pericardium, Inflammation, Chronic Active 1 2.0Pericardium, Mineralization 1 3.0


Adrenal Cortex + 26Accessory Adrenal Cortical Nodule 1Subcapsular, Hyperplasia 24 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + 26.........................................................................................................................................................................................................





DAY ON TEST0229

.................................................................................................................................................................



00503 * TOTALS


Islets, Pancreatic + 26.........................................................................................................................................................................................................

Parathyroid Gland + 21.........................................................................................................................................................................................................

Pituitary Gland + 26.........................................................................................................................................................................................................

Thyroid Gland + 25Infiltration Cellular, Lymphocyte 1 1.0


Tissue NOS 1Abscess 1 4.0

GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + 25.........................................................................................................................................................................................................

Ovary + 26Cyst 1 2.0

.........................................................................................................................................................................................................

Uterus + 26Endometrium, Hyperplasia, Cystic 1 1.0Lumen, Dilatation 2 1.5

.........................................................................................................................................................................................................

Vagina + 26





DAY ON TEST0229

.................................................................................................................................................................



00503 * TOTALS



Bone Marrow + 26Myeloid Cell, Hyperplasia 2 3.0

.........................................................................................................................................................................................................

Lymph Node 1.........................................................................................................................................................................................................

Lymph Node, Mandibular + 25Hyperplasia, Lymphoid 2 1.5

.........................................................................................................................................................................................................

Lymph Node, Mesenteric + 25Hyperplasia, Lymphoid 1 11 1.4

.........................................................................................................................................................................................................

Spleen + 26Hematopoietic Cell Proliferation 2 3.5Hyperplasia, Lymphoid 2 3.5

.........................................................................................................................................................................................................

Thymus + 26Hyperplasia, Lymphoid 2 2 2.0


Mammary Gland + 24.........................................................................................................................................................................................................

Skin + 26





DAY ON TEST0229

.................................................................................................................................................................



00503 * TOTALS



Bone, Femur + 26.........................................................................................................................................................................................................

Skeletal Muscle + 26

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain, Brain Stem + 26.........................................................................................................................................................................................................

Brain, Cerebellum + 26.........................................................................................................................................................................................................

Brain, Cerebrum + 26


Lung + 26Inflammation, Chronic Active 1 2.0Mediastinum, Inflammation, Chronic Active 1 2.0Mediastinum, Mineralization 1 4.0

.........................................................................................................................................................................................................

Nose + 26.........................................................................................................................................................................................................

Trachea + 26





DAY ON TEST0229

.................................................................................................................................................................



00503 * TOTALS



Eye + 26.........................................................................................................................................................................................................

Harderian Gland + 26

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + 26Infiltration Cellular, Lymphocyte 3 1.0

.........................................................................................................................................................................................................

Urinary Bladder + 26Infiltration Cellular, Lymphocyte 1 1.0





DAY ON TEST0229

.................................................................................................................................................................



00503 * TOTALS



Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Gallbladder + + + + + + + + + + + + + + + + + A + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + A + + + + + + +Hyperplasia, Lymphoid 2 3

.........................................................................................................................................................................................................


Intestine Large, Rectum + + + + + + + + + + + + + + + + + A + + + + + + +.........................................................................................................................................................................................................


Intestine Small, Ileum + + + + + + + + + + + + + + + + + A + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + + + + + + + + A + + + + + + +.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + +Tension Lipidosis 1 1 1Vacuolization Cytoplasmic 1 1 1 1 1 2

.........................................................................................................................................................................................................

Mesentery +Hemorrhage 3

.........................................................................................................................................................................................................





DAY ON TEST0198

0335

0335

0333

0333

0337

0336

0336

0335

0335

0334

0334

0334

0332

0338

0338

0335

0305

0335

0335

0335

0335

0339

0334

0283

.................................................................................................................................................................



00209

00289

00290

00291

00292

00333

00351

00352

00353

00354

00360

00376

00377

00378

00400

00414

00431

00446

00513

00518

00519

00520

00538

00540

00552

females(cont...)


Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1 2 1 1 1 2 1 1 1 1 1 1 1 1

.........................................................................................................................................................................................................


Stomach, Glandular + + + + + + + + + + + + + + + + + A + + + + + + +


Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation, Chronic Active 1


Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Subcapsular, Hyperplasia 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + M + + + + + + + + + + +.........................................................................................................................................................................................................


Parathyroid Gland + + + + M M + + + M + + + + + M + + + + + + M + +





DAY ON TEST0198

0335

0335

0333

0333

0337

0336

0336

0335

0335

0334

0334

0334

0332

0338

0338

0335

0305

0335

0335

0335

0335

0339

0334

0283

.................................................................................................................................................................



00209

00289

00290

00291

00292

00333

00351

00352

00353

00354

00360

00376

00377

00378

00400

00414

00431

00446

00513

00518

00519

00520

00538

00540

00552

females(cont...)


.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + M + + + + + + + + +Degeneration 1


GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + + M + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Ovary + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Polymorphonuclear 2Endometrium, Hyperplasia, Cystic 1 2 1Lumen, Dilatation 1 1 1 2 2 1 1 1 1

.........................................................................................................................................................................................................

Vagina M + + + + + + + + + + + + + + + + + + + + + + + +


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +





DAY ON TEST0198

0335

0335

0333

0333

0337

0336

0336

0335

0335

0334

0334

0334

0332

0338

0338

0335

0305

0335

0335

0335

0335

0339

0334

0283

.................................................................................................................................................................



00209

00289

00290

00291

00292

00333

00351

00352

00353

00354

00360

00376

00377

00378

00400

00414

00431

00446

00513

00518

00519

00520

00538

00540

00552

females(cont...)


.........................................................................................................................................................................................................

Lymph Node +Lumbar, Hyperplasia, Lymphoid 2

.........................................................................................................................................................................................................

Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, Lymphoid 1 2 2 2 1 1 1 1

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Hematopoietic Cell Proliferation 3 2 4 3 2Hyperplasia, Lymphoid 2 2 2 2

.........................................................................................................................................................................................................

Thymus + + M + + + + + + + + + + + + + + A + + + + + + +Hyperplasia, Lymphoid 2 2


Mammary Gland + + M + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + +


Bone, Femur + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................





DAY ON TEST0198

0335

0335

0333

0333

0337

0336

0336

0335

0335

0334

0334

0334

0332

0338

0338

0335

0305

0335

0335

0335

0335

0339

0334

0283

.................................................................................................................................................................



00209

00289

00290

00291

00292

00333

00351

00352

00353

00354

00360

00376

00377

00378

00400

00414

00431

00446

00513

00518

00519

00520

00538

00540

00552

females(cont...)


Skeletal Muscle + + + + + + + + + + + + + + + + + + + + + + + + +Atrophy 2 2Cyst 4

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain, Brain Stem + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................


Brain, Cerebrum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Peripheral Nerve + +Axon, Degeneration 2 3

.........................................................................................................................................................................................................

Spinal Cord +Axon, Degeneration 2


Lung + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +





DAY ON TEST0198

0335

0335

0333

0333

0337

0336

0336

0335

0335

0334

0334

0334

0332

0338

0338

0335

0305

0335

0335

0335

0335

0339

0334

0283

.................................................................................................................................................................



00209

00289

00290

00291

00292

00333

00351

00352

00353

00354

00360

00376

00377

00378

00400

00414

00431

00446

00513

00518

00519

00520

00538

00540

00552

females(cont...)



Eye + + + + + + + + + + + + + + + + + A + + + + + + +Cataract 1

.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Casts Protein 1Cyst 1Infiltration Cellular, Lymphocyte 1 1 2 1 1 1 1 1Mineralization 1

.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1





DAY ON TEST0198

0335

0335

0333

0333

0337

0336

0336

0335

0335

0334

0334

0334

0332

0338

0338

0335

0305

0335

0335

0335

0335

0339

0334

0283

.................................................................................................................................................................



00209

00289

00290

00291

00292

00333

00351

00352

00353

00354

00360

00376

00377

00378

00400

00414

00431

00446

00513

00518

00519

00520

00538

00540

00552

females(cont...)



Esophagus + 26.........................................................................................................................................................................................................

Gallbladder + 25.........................................................................................................................................................................................................


.........................................................................................................................................................................................................






Liver + 26Tension Lipidosis 3 1.0Vacuolization Cytoplasmic 6 1.2

.........................................................................................................................................................................................................

Mesentery 1Hemorrhage 1 3.0

.........................................................................................................................................................................................................





DAY ON TEST0336

.................................................................................................................................................................



00632 * TOTALS


Pancreas + 26.........................................................................................................................................................................................................

Salivary Glands + 26Infiltration Cellular, Lymphocyte 2 15 1.2

.........................................................................................................................................................................................................




Blood Vessel + 26.........................................................................................................................................................................................................

Heart + 26Inflammation, Chronic Active 1 1.0


Adrenal Cortex + 26Subcapsular, Hyperplasia 25 1.0

.........................................................................................................................................................................................................

Adrenal Medulla + 25.........................................................................................................................................................................................................


Parathyroid Gland + 21





DAY ON TEST0336

.................................................................................................................................................................



00632 * TOTALS


.........................................................................................................................................................................................................

Pituitary Gland + 26.........................................................................................................................................................................................................

Thyroid Gland + 25Degeneration 1 1.0


GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + 25.........................................................................................................................................................................................................

Ovary + 26.........................................................................................................................................................................................................

Uterus + 26Infiltration Cellular, Polymorphonuclear 1 2.0Endometrium, Hyperplasia, Cystic 3 1.3Lumen, Dilatation 1 10 1.2

.........................................................................................................................................................................................................

Vagina + 25


Bone Marrow + 26





DAY ON TEST0336

.................................................................................................................................................................



00632 * TOTALS


.........................................................................................................................................................................................................

Lymph Node 1Lumbar, Hyperplasia, Lymphoid 1 2.0

.........................................................................................................................................................................................................

Lymph Node, Mandibular + 26.........................................................................................................................................................................................................

Lymph Node, Mesenteric + 26Hyperplasia, Lymphoid 8 1.4

.........................................................................................................................................................................................................


.........................................................................................................................................................................................................

Thymus + 24Hyperplasia, Lymphoid 2 3 2.0


Mammary Gland + 25.........................................................................................................................................................................................................

Skin + 26


Bone, Femur + 26.........................................................................................................................................................................................................





DAY ON TEST0336

.................................................................................................................................................................



00632 * TOTALS


Skeletal Muscle + 26Atrophy 2 2.0Cyst 1 4.0

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain, Brain Stem + 26.........................................................................................................................................................................................................


Brain, Cerebrum + 26.........................................................................................................................................................................................................

Peripheral Nerve 2Axon, Degeneration 2 2.5

.........................................................................................................................................................................................................

Spinal Cord 1Axon, Degeneration 1 2.0


Lung + 26.........................................................................................................................................................................................................

Nose + 26.........................................................................................................................................................................................................

Trachea + 26





DAY ON TEST0336

.................................................................................................................................................................



00632 * TOTALS



Eye + 25Cataract 1 1.0

.........................................................................................................................................................................................................


URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + 26Casts Protein 1 1.0Cyst 1 1.0Infiltration Cellular, Lymphocyte 1 9 1.1Mineralization 1 1.0

.........................................................................................................................................................................................................

Urinary Bladder + 26Infiltration Cellular, Lymphocyte 1 1.0





DAY ON TEST0336

.................................................................................................................................................................



00632 * TOTALS



Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +Adventitia, Necrosis 2

.........................................................................................................................................................................................................

Gallbladder + + + + + + + + + + + + + + + A + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, Lymphoid 2 2

.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + A + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, Lymphoid 2

.........................................................................................................................................................................................................




Liver + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation, Chronic Active 1 1Tension Lipidosis 1 2 1 2Vacuolization Cytoplasmic 1 1 1 1

.........................................................................................................................................................................................................





DAY ON TEST0334

0334

0333

0333

0331

0331

0335

0335

0333

0333

0338

0335

0335

0296

0226

0044

0335

0335

0335

0333

0333

0336

0336

0336

0333

.................................................................................................................................................................



00300

00301

00302

00303

00304

00317

00325

00326

00363

00364

00403

00429

00430

00445

00451

00483

00505

00506

00507

00508

00529

00544

00545

00546

00548

females(cont...)


Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1 1 1 1 1 2 1 1 1 1 1 1 1

.........................................................................................................................................................................................................




Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + +Bacterium XPericardium, Necrosis 2


Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +Subcapsular, Hyperplasia 1 1 1 1 1 1 1 1 1 2 2 2 2 1 1 1 2 1 1 1 1 1 1

.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................






DAY ON TEST0334

0334

0333

0333

0331

0331

0335

0335

0333

0333

0338

0335

0335

0296

0226

0044

0335

0335

0335

0333

0333

0336

0336

0336

0333

.................................................................................................................................................................



00300

00301

00302

00303

00304

00317

00325

00326

00363

00364

00403

00429

00430

00445

00451

00483

00505

00506

00507

00508

00529

00544

00545

00546

00548

females(cont...)


Parathyroid Gland + + + + + + + + M M M + + + + M M + + + + + + + +Cyst 1

.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +Cyst 1Degeneration 1 1Ectopic Thymus X X


Tissue NOS +

GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + + + + + + + + + + + + + M + + + + + + + + + + +.........................................................................................................................................................................................................

Ovary + + + + + + + + + + + + + + + + + + + + + + + + +Cyst

.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Polymorphonuclear 2 2 3Endometrium, Hyperplasia, Cystic 2 2 2 2Lumen, Dilatation 2 1 2 1 1 1 1 1 1 2 2

.........................................................................................................................................................................................................

Vagina + + + + + + + + + + + + + + + + + + + + + + + + +





DAY ON TEST0334

0334

0333

0333

0331

0331

0335

0335

0333

0333

0338

0335

0335

0296

0226

0044

0335

0335

0335

0333

0333

0336

0336

0336

0333

.................................................................................................................................................................



00300

00301

00302

00303

00304

00317

00325

00326

00363

00364

00403

00429

00430

00445

00451

00483

00505

00506

00507

00508

00529

00544

00545

00546

00548

females(cont...)



Bone Marrow + + + + + + + + + + + + + + + A + + + + + + + + +.........................................................................................................................................................................................................

Lymph Node +.........................................................................................................................................................................................................


Lymph Node, Mesenteric + + + + + + + + + + + + + M + + + + + + + + + + +Hyperplasia, Lymphoid 2 3 1 1 2 2

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + A + + + + + + + + +Hematopoietic Cell Proliferation 2 2 2 2Hyperplasia, Lymphoid 3 2 2 2 2

.........................................................................................................................................................................................................

Thymus + + + + + + + + + + + + + A + + + + + + + + + + +Bacterium XForeign Body XHyperplasia, Lymphoid 2 2Necrosis 4


Mammary Gland + + + + + + + + + + + + + + + M + + + + + + + + +Alveolus, Hyperplasia 2

.........................................................................................................................................................................................................





DAY ON TEST0334

0334

0333

0333

0331

0331

0335

0335

0333

0333

0338

0335

0335

0296

0226

0044

0335

0335

0335

0333

0333

0336

0336

0336

0333

.................................................................................................................................................................



00300

00301

00302

00303

00304

00317

00325

00326

00363

00364

00403

00429

00430

00445

00451

00483

00505

00506

00507

00508

00529

00544

00545

00546

00548

females(cont...)


Skin + + + + + + + + + + + + + + + + + + + + + + + + +


Bone +.........................................................................................................................................................................................................

Bone, Femur + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Skeletal Muscle + + + + + + + + + + + + + + + + + + + + + + + + +

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain, Brain Stem + + + + + + + + + + + + + + + + + + + + + + + + +Gliosis

.........................................................................................................................................................................................................


Brain, Cerebrum + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1Mineralization 1


Lung + + + + + + + + + + + + + + + + + + + + + + + + +Bacterium X





DAY ON TEST0334

0334

0333

0333

0331

0331

0335

0335

0333

0333

0338

0335

0335

0296

0226

0044

0335

0335

0335

0333

0333

0336

0336

0336

0333

.................................................................................................................................................................



00300

00301

00302

00303

00304

00317

00325

00326

00363

00364

00403

00429

00430

00445

00451

00483

00505

00506

00507

00508

00529

00544

00545

00546

00548

females(cont...)


Mediastinum, Foreign Body XMediastinum, Necrosis 3

.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +


Eye + + + + + + + + + + + + + A + A + + + + + + + + +.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Casts Protein 1Infiltration Cellular, Lymphocyte 1 1 1 2 1 1Metaplasia, Osseous 1

.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1 1 1





DAY ON TEST0334

0334

0333

0333

0331

0331

0335

0335

0333

0333

0338

0335

0335

0296

0226

0044

0335

0335

0335

0333

0333

0336

0336

0336

0333

.................................................................................................................................................................



00300

00301

00302

00303

00304

00317

00325

00326

00363

00364

00403

00429

00430

00445

00451

00483

00505

00506

00507

00508

00529

00544

00545

00546

00548

females(cont...)



Esophagus + + 27Adventitia, Necrosis 1 2.0

.........................................................................................................................................................................................................

Gallbladder + + 26.........................................................................................................................................................................................................

Intestine Large, Cecum + + 27Hyperplasia, Lymphoid 2 2.0

.........................................................................................................................................................................................................

Intestine Large, Colon + + 26.........................................................................................................................................................................................................

Intestine Large, Rectum + + 27Hyperplasia, Lymphoid 1 2.0

.........................................................................................................................................................................................................

Intestine Small, Duodenum + + 27.........................................................................................................................................................................................................

Intestine Small, Ileum + + 27.........................................................................................................................................................................................................

Intestine Small, Jejunum + + 27.........................................................................................................................................................................................................

Liver + + 27Inflammation, Chronic Active 2 1.0Tension Lipidosis 2 5 1.6Vacuolization Cytoplasmic 4 1.0

.........................................................................................................................................................................................................





DAY ON TEST0335

0326

.................................................................................................................................................................



00550

00673 * TOTALS


Pancreas + + 27.........................................................................................................................................................................................................

Salivary Glands + + 27Infiltration Cellular, Lymphocyte 1 14 1.1

.........................................................................................................................................................................................................

Stomach, Forestomach + + 27.........................................................................................................................................................................................................

Stomach, Glandular + + 27


Blood Vessel + + 27.........................................................................................................................................................................................................

Heart + + 27Bacterium 1Pericardium, Necrosis 1 2.0


Adrenal Cortex + + 27Subcapsular, Hyperplasia 1 1 25 1.2

.........................................................................................................................................................................................................

Adrenal Medulla + + 27.........................................................................................................................................................................................................

Islets, Pancreatic + + 27.........................................................................................................................................................................................................





DAY ON TEST0335

0326

.................................................................................................................................................................



00550

00673 * TOTALS


Parathyroid Gland + + 22Cyst 1 1.0

.........................................................................................................................................................................................................

Pituitary Gland + + 27.........................................................................................................................................................................................................

Thyroid Gland + + 27Cyst 1 1.0Degeneration 2 1.0Ectopic Thymus 2


Tissue NOS 1

GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + + 26.........................................................................................................................................................................................................

Ovary + + 27Cyst 1 1 1.0

.........................................................................................................................................................................................................

Uterus + + 27Infiltration Cellular, Polymorphonuclear 3 2.3Endometrium, Hyperplasia, Cystic 4 2.0Lumen, Dilatation 1 12 1.3

.........................................................................................................................................................................................................

Vagina + + 27





DAY ON TEST0335

0326

.................................................................................................................................................................



00550

00673 * TOTALS



Bone Marrow + + 26.........................................................................................................................................................................................................

Lymph Node 1.........................................................................................................................................................................................................

Lymph Node, Mandibular + + 27.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + 26Hyperplasia, Lymphoid 6 1.8

.........................................................................................................................................................................................................

Spleen + + 26Hematopoietic Cell Proliferation 4 2.0Hyperplasia, Lymphoid 5 2.2

.........................................................................................................................................................................................................

Thymus + + 26Bacterium 1Foreign Body 1Hyperplasia, Lymphoid 2 2.0Necrosis 1 4.0


Mammary Gland + + 26Alveolus, Hyperplasia 1 2.0

.........................................................................................................................................................................................................





DAY ON TEST0335

0326

.................................................................................................................................................................



00550

00673 * TOTALS


Skin + + 27


Bone 1.........................................................................................................................................................................................................

Bone, Femur + + 27.........................................................................................................................................................................................................


NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain, Brain Stem + + 27Gliosis 3 1 3.0

.........................................................................................................................................................................................................

Brain, Cerebellum + + 27.........................................................................................................................................................................................................

Brain, Cerebrum + + 27Infiltration Cellular, Lymphocyte 1 1.0Mineralization 1 1.0


Lung + + 27Bacterium 1





DAY ON TEST0335

0326

.................................................................................................................................................................



00550

00673 * TOTALS


Mediastinum, Foreign Body 1Mediastinum, Necrosis 1 3.0

.........................................................................................................................................................................................................

Nose + + 27.........................................................................................................................................................................................................

Trachea + + 27


Eye + + 25.........................................................................................................................................................................................................

Harderian Gland + + 27

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + 27Casts Protein 1 1.0Infiltration Cellular, Lymphocyte 6 1.2Metaplasia, Osseous 1 1.0

.........................................................................................................................................................................................................

Urinary Bladder + + 27Infiltration Cellular, Lymphocyte 1 4 1.0





DAY ON TEST0335

0326

.................................................................................................................................................................



00550

00673 * TOTALS



Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Gallbladder + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + A A +Hyperplasia, Lymphoid 2 2 2Epithelium, Hyperplasia 2

.........................................................................................................................................................................................................


Intestine Large, Rectum + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, Lymphoid 3

.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + + + + + A A +.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + + + + + + + + + + + + + A A +.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + + + + + A A +.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + +Hematopoietic Cell ProliferationInflammation, Chronic Active 1Necrosis 1Tension Lipidosis 1 1 1 1 2 1 1Vacuolization Cytoplasmic 1 1





DAY ON TEST0334

0334

0337

0337

0339

0339

0336

0336

0336

0335

0335

0334

0334

0334

0336

0336

0336

0336

0336

0336

0335

0335

0176

0199

0335

.................................................................................................................................................................



00296

00297

00318

00319

00327

00331

00338

00339

00340

00341

00359

00383

00384

00385

00404

00405

00406

00407

00408

00425

00435

00436

00458

00462

00532

females(cont...)


.........................................................................................................................................................................................................

Mesentery +Fat, Necrosis 3

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1Acinar Cell, Degeneration 1

.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1 1 2 1 1 1 2 1 1

.........................................................................................................................................................................................................


Stomach, Glandular + + + + + + + + + + + + + + + + + + + + + + A A +


Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + +Congestion 3 2Inflammation, Chronic Active 1


Adrenal Cortex + + + + + + + + + + + + + + + + + + + + + + + + +





DAY ON TEST0334

0334

0337

0337

0339

0339

0336

0336

0336

0335

0335

0334

0334

0334

0336

0336

0336

0336

0336

0336

0335

0335

0176

0199

0335

.................................................................................................................................................................



00296

00297

00318

00319

00327

00331

00338

00339

00340

00341

00359

00383

00384

00385

00404

00405

00406

00407

00408

00425

00435

00436

00458

00462

00532

females(cont...)


Subcapsular, Hyperplasia 1 1 1 1 1 1 1 1 2 2 1 2 1 1 1 1 1 2 1 2 1 1 1 1 2.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................


Parathyroid Gland + + + + M + M M + + + + + + + + + + M + M + + + +.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +


GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + + + M + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Ovary + + + + + + + + + + + + + + + + + + + + + + + + +Cyst 2Bilateral, Cyst 2

.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Polymorphonuclear 2 2 2Endometrium, Hyperplasia, Cystic 2 2 2 2 2





DAY ON TEST0334

0334

0337

0337

0339

0339

0336

0336

0336

0335

0335

0334

0334

0334

0336

0336

0336

0336

0336

0336

0335

0335

0176

0199

0335

.................................................................................................................................................................



00296

00297

00318

00319

00327

00331

00338

00339

00340

00341

00359

00383

00384

00385

00404

00405

00406

00407

00408

00425

00435

00436

00458

00462

00532

females(cont...)


Lumen, Dilatation 3 2 1 1 1 2 1 1 2 2 2 2 2 1.........................................................................................................................................................................................................

Vagina + + + + + + + + + + + + + + + + + + + + + + + + +


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + A + +Myeloid Cell, Hyperplasia 2 2 3 3

.........................................................................................................................................................................................................

Lymph Node A.........................................................................................................................................................................................................

Lymph Node, Mandibular + + + + + + + + + + + + + + + + + + + + + + A + +Hyperplasia, Lymphoid 2 3

.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + A +Hyperplasia, Lymphoid 2 1 1 2 1 1

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Hematopoietic Cell Proliferation 3 2 2 4Hyperplasia, Lymphoid 3 2 3 2 3 3 1

.........................................................................................................................................................................................................

Thymus + M + + + + + + + + + + + + + + + + + + + + A A +Hyperplasia, Lymphoid 2 2 2






DAY ON TEST0334

0334

0337

0337

0339

0339

0336

0336

0336

0335

0335

0334

0334

0334

0336

0336

0336

0336

0336

0336

0335

0335

0176

0199

0335

.................................................................................................................................................................



00296

00297

00318

00319

00327

00331

00338

00339

00340

00341

00359

00383

00384

00385

00404

00405

00406

00407

00408

00425

00435

00436

00458

00462

00532

females(cont...)


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + +


Bone, Femur + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Skeletal Muscle + + + + + + + + + + + + + + + + + + + + + + + + +

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain, Brain Stem + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................


Brain, Cerebrum + + + + + + + + + + + + + + + + + + + + + + + + +Mineralization 1 1 1 1


Lung + + + + + + + + + + + + + + + + + + + + + + A + +.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................





DAY ON TEST0334

0334

0337

0337

0339

0339

0336

0336

0336

0335

0335

0334

0334

0334

0336

0336

0336

0336

0336

0336

0335

0335

0176

0199

0335

.................................................................................................................................................................



00296

00297

00318

00319

00327

00331

00338

00339

00340

00341

00359

00383

00384

00385

00404

00405

00406

00407

00408

00425

00435

00436

00458

00462

00532

females(cont...)


Trachea + + + + + + + + + + + + + + + + + + + + M + + + +


Eye + + + + + + + + + + + + + + + + + + + + + + A + +.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Casts Protein 1 1Hydronephrosis 4Infiltration Cellular, Lymphocyte 1 1 1 1Inflammation, Suppurative 4Nephropathy 4

.........................................................................................................................................................................................................

Ureter +Inflammation, Suppurative 3Lumen, Dilatation 2

.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1 1





DAY ON TEST0334

0334

0337

0337

0339

0339

0336

0336

0336

0335

0335

0334

0334

0334

0336

0336

0336

0336

0336

0336

0335

0335

0176

0199

0335

.................................................................................................................................................................



00296

00297

00318

00319

00327

00331

00338

00339

00340

00341

00359

00383

00384

00385

00404

00405

00406

00407

00408

00425

00435

00436

00458

00462

00532

females(cont...)



Esophagus + + 27.........................................................................................................................................................................................................

Gallbladder + + 27.........................................................................................................................................................................................................

Intestine Large, Cecum + + 25Hyperplasia, Lymphoid 3 2.0Epithelium, Hyperplasia 1 2.0

.........................................................................................................................................................................................................

Intestine Large, Colon + + 27.........................................................................................................................................................................................................

Intestine Large, Rectum + + 27Hyperplasia, Lymphoid 1 3.0

.........................................................................................................................................................................................................

Intestine Small, Duodenum + + 25.........................................................................................................................................................................................................

Intestine Small, Ileum + + 25.........................................................................................................................................................................................................

Intestine Small, Jejunum + + 25.........................................................................................................................................................................................................

Liver + + 27Hematopoietic Cell Proliferation 1 1 1.0Inflammation, Chronic Active 1 1.0Necrosis 1 1.0Tension Lipidosis 7 1.1Vacuolization Cytoplasmic 2 3 1.3





DAY ON TEST0335

0312

.................................................................................................................................................................



00533

00609 * TOTALS


.........................................................................................................................................................................................................

Mesentery 1Fat, Necrosis 1 3.0

.........................................................................................................................................................................................................

Pancreas + + 27Infiltration Cellular, Lymphocyte 1 1.0Acinar Cell, Degeneration 1 1.0

.........................................................................................................................................................................................................

Salivary Glands + M 26Infiltration Cellular, Lymphocyte 2 10 1.3

.........................................................................................................................................................................................................


Stomach, Glandular + + 25


Blood Vessel + + 27.........................................................................................................................................................................................................

Heart + + 27Congestion 2 2.5Inflammation, Chronic Active 1 1.0


Adrenal Cortex + + 27





DAY ON TEST0335

0312

.................................................................................................................................................................



00533

00609 * TOTALS


Subcapsular, Hyperplasia 1 1 27 1.2.........................................................................................................................................................................................................

Adrenal Medulla + + 27.........................................................................................................................................................................................................


Parathyroid Gland + + 22.........................................................................................................................................................................................................

Pituitary Gland + + 27.........................................................................................................................................................................................................

Thyroid Gland + + 27


GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + + 26.........................................................................................................................................................................................................

Ovary + + 27Cyst 1 2.0Bilateral, Cyst 1 2.0

.........................................................................................................................................................................................................

Uterus + + 27Infiltration Cellular, Polymorphonuclear 3 2.0Endometrium, Hyperplasia, Cystic 5 2.0





DAY ON TEST0335

0312

.................................................................................................................................................................



00533

00609 * TOTALS


Lumen, Dilatation 14 1.6.........................................................................................................................................................................................................

Vagina + + 27


Bone Marrow + + 26Myeloid Cell, Hyperplasia 4 2.5

.........................................................................................................................................................................................................

Lymph Node 0.........................................................................................................................................................................................................

Lymph Node, Mandibular + M 25Hyperplasia, Lymphoid 2 2.5

.........................................................................................................................................................................................................


.........................................................................................................................................................................................................

Spleen + + 27Hematopoietic Cell Proliferation 4 5 3.0Hyperplasia, Lymphoid 7 2.4

.........................................................................................................................................................................................................

Thymus + M 23Hyperplasia, Lymphoid 3 2.0






DAY ON TEST0335

0312

.................................................................................................................................................................



00533

00609 * TOTALS


Mammary Gland + + 27.........................................................................................................................................................................................................

Skin + + 27


Bone, Femur + + 27.........................................................................................................................................................................................................


NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain, Brain Stem + + 27.........................................................................................................................................................................................................


Brain, Cerebrum + + 27Mineralization 4 1.0


Lung + + 26.........................................................................................................................................................................................................

Nose + + 27.........................................................................................................................................................................................................





DAY ON TEST0335

0312

.................................................................................................................................................................



00533

00609 * TOTALS


Trachea + + 26


Eye + + 26.........................................................................................................................................................................................................

Harderian Gland + + 27

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + 27Casts Protein 1 3 1.0Hydronephrosis 1 4.0Infiltration Cellular, Lymphocyte 1 5 1.0Inflammation, Suppurative 1 4.0Nephropathy 1 4.0

.........................................................................................................................................................................................................

Ureter 1Inflammation, Suppurative 1 3.0Lumen, Dilatation 1 2.0

.........................................................................................................................................................................................................

Urinary Bladder + + 27Infiltration Cellular, Lymphocyte 2 1.0





DAY ON TEST0335

0312

.................................................................................................................................................................



00533

00609 * TOTALS



Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Gallbladder + + + + + + + + + + + + + + + + + + A + + + + + +.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + A + A + + + + + +Hyperplasia, Lymphoid 2 2

.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + + + + + A + + + + + +.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + + + + + A + + + + + +.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + + + + + A + + + + + +.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + + + + + + + + + A + + + + + +.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + + + + + + + + + A + + + + + +.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + + + + + + + + + + + +Basophilic Focus 2Infiltration Cellular, Lymphocyte 1Tension Lipidosis 1 1 1Vacuolization Cytoplasmic 1 1 1 1 1 1 1 1 1 1

.........................................................................................................................................................................................................

Mesentery +





DAY ON TEST0334

0332

0339

0336

0336

0335

0335

0335

0335

0334

0334

0333

0338

0336

0336

0288

0301

0307

0255

0064

0335

0335

0335

0334

0332

.................................................................................................................................................................



00310

00311

00329

00345

00346

00347

00369

00370

00371

00372

00373

00387

00418

00419

00420

00447

00448

00449

00453

00497

00525

00526

00527

00528

00554

females(cont...)


Hemorrhage 3Fat, Necrosis 4

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +Cytoplasmic AlterationInfiltration Cellular, Lymphocyte 1 1 1Acinar Cell, Degeneration 2

.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1 1 1 1 1 1 1 1 1

.........................................................................................................................................................................................................


Stomach, Glandular + + + + + + + + + + + + + + + + + + A + + + + + +


Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + +Inflammation, Chronic Active 4


Adrenal Cortex + + + + + + + + + + + + + + + + + + A + + + + + +Subcapsular, Hyperplasia 1 1 1 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 2 2 1 1

.........................................................................................................................................................................................................





DAY ON TEST0334

0332

0339

0336

0336

0335

0335

0335

0335

0334

0334

0333

0338

0336

0336

0288

0301

0307

0255

0064

0335

0335

0335

0334

0332

.................................................................................................................................................................



00310

00311

00329

00345

00346

00347

00369

00370

00371

00372

00373

00387

00418

00419

00420

00447

00448

00449

00453

00497

00525

00526

00527

00528

00554

females(cont...)


Adrenal Medulla + + + + + + + + + + + + + + + + + + A + + + + + +.........................................................................................................................................................................................................


Parathyroid Gland + + M + + + M + + + + + M M + + M + + + + + + + +.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + A + + + + + +Ectopic Thymus X


Tissue NOS +Mediastinum, Abscess 4Mediastinum, Foreign Body X

GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +Degeneration 3

.........................................................................................................................................................................................................

Ovary + + + + + + + + + + + + + + + + + + A + + + + + +Cyst 2Pigmentation 2

.........................................................................................................................................................................................................





DAY ON TEST0334

0332

0339

0336

0336

0335

0335

0335

0335

0334

0334

0333

0338

0336

0336

0288

0301

0307

0255

0064

0335

0335

0335

0334

0332

.................................................................................................................................................................



00310

00311

00329

00345

00346

00347

00369

00370

00371

00372

00373

00387

00418

00419

00420

00447

00448

00449

00453

00497

00525

00526

00527

00528

00554

females(cont...)


Uterus + + + + + + + + + + + + + + + + + + + + + + + + +Edema 3Infiltration Cellular, Polymorphonuclear 2 2 2Endometrium, Hyperplasia, Cystic 2 1 2 2Lumen, Dilatation 2 1 2 1 1 1 1 1

.........................................................................................................................................................................................................

Vagina + + + + + + + + + + + + + + + + M + M + + + + + +


Bone Marrow + + + + + + + + + + + + + + + + + + A + + + + + +Myeloid Cell, Hyperplasia 2

.........................................................................................................................................................................................................

Lymph Node + +Lumbar, Hyperplasia, Lymphoid 2

.........................................................................................................................................................................................................


Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, Lymphoid 2 2 2 1 2 1

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Hematopoietic Cell Proliferation 4 3 2 3 2 4 4 2Hyperplasia, Lymphoid 2 1 2 2 2 2

.........................................................................................................................................................................................................

Thymus + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, Lymphoid 2 2Inflammation, Chronic Active 3





DAY ON TEST0334

0332

0339

0336

0336

0335

0335

0335

0335

0334

0334

0333

0338

0336

0336

0288

0301

0307

0255

0064

0335

0335

0335

0334

0332

.................................................................................................................................................................



00310

00311

00329

00345

00346

00347

00369

00370

00371

00372

00373

00387

00418

00419

00420

00447

00448

00449

00453

00497

00525

00526

00527

00528

00554

females(cont...)



Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + +


Bone +.........................................................................................................................................................................................................

Bone, Femur + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Skeletal Muscle + + + + + + + + + + + + + + + + + + + + + + + + +

NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain, Brain Stem + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................


Brain, Cerebrum + + + + + + + + + + + + + + + + + + + + + + + + +Compression 2Mineralization 1 1





DAY ON TEST0334

0332

0339

0336

0336

0335

0335

0335

0335

0334

0334

0333

0338

0336

0336

0288

0301

0307

0255

0064

0335

0335

0335

0334

0332

.................................................................................................................................................................



00310

00311

00329

00345

00346

00347

00369

00370

00371

00372

00373

00387

00418

00419

00420

00447

00448

00449

00453

00497

00525

00526

00527

00528

00554

females(cont...)



Lung + + + + + + + + + + + + + + + + + + + + + + + + +AbscessForeign Body XInflammation, Chronic Active 3Necrosis 2

.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +


Eye + + + + + + + + + + + + + + + + A + A + + + + + +.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + A + + + + + +

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Casts Protein 1 1Cyst 1GlomerulosclerosisInfiltration Cellular, Lymphocyte 1 1 1 1Nephropathy





DAY ON TEST0334

0332

0339

0336

0336

0335

0335

0335

0335

0334

0334

0333

0338

0336

0336

0288

0301

0307

0255

0064

0335

0335

0335

0334

0332

.................................................................................................................................................................



00310

00311

00329

00345

00346

00347

00369

00370

00371

00372

00373

00387

00418

00419

00420

00447

00448

00449

00453

00497

00525

00526

00527

00528

00554

females(cont...)


.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + A + + + + + +Infiltration Cellular, Lymphocyte 1





DAY ON TEST0334

0332

0339

0336

0336

0335

0335

0335

0335

0334

0334

0333

0338

0336

0336

0288

0301

0307

0255

0064

0335

0335

0335

0334

0332

.................................................................................................................................................................



00310

00311

00329

00345

00346

00347

00369

00370

00371

00372

00373

00387

00418

00419

00420

00447

00448

00449

00453

00497

00525

00526

00527

00528

00554

females(cont...)



Esophagus + + 27.........................................................................................................................................................................................................

Gallbladder + A 25.........................................................................................................................................................................................................

Intestine Large, Cecum + A 24Hyperplasia, Lymphoid 2 2.0

.........................................................................................................................................................................................................

Intestine Large, Colon + A 25.........................................................................................................................................................................................................

Intestine Large, Rectum + A 25.........................................................................................................................................................................................................

Intestine Small, Duodenum + A 25.........................................................................................................................................................................................................

Intestine Small, Ileum + A 25.........................................................................................................................................................................................................

Intestine Small, Jejunum + A 25.........................................................................................................................................................................................................

Liver + + 27Basophilic Focus 1 2.0Infiltration Cellular, Lymphocyte 1 1.0Tension Lipidosis 1 4 1.0Vacuolization Cytoplasmic 10 1.0

.........................................................................................................................................................................................................

Mesentery 1





DAY ON TEST0332

0292

.................................................................................................................................................................



00555

00674 * TOTALS


Hemorrhage 1 3.0Fat, Necrosis 1 4.0

.........................................................................................................................................................................................................

Pancreas + A 26Cytoplasmic Alteration 1 1 1.0Infiltration Cellular, Lymphocyte 3 1.0Acinar Cell, Degeneration 1 2.0

.........................................................................................................................................................................................................

Salivary Glands + + 27Infiltration Cellular, Lymphocyte 1 10 1.0

.........................................................................................................................................................................................................


Stomach, Glandular + A 25


Blood Vessel + + 27.........................................................................................................................................................................................................

Heart + A 26Inflammation, Chronic Active 1 4.0


Adrenal Cortex + + 26Subcapsular, Hyperplasia 1 2 24 1.2

.........................................................................................................................................................................................................





DAY ON TEST0332

0292

.................................................................................................................................................................



00555

00674 * TOTALS


Adrenal Medulla + + 26.........................................................................................................................................................................................................


Parathyroid Gland + + 22.........................................................................................................................................................................................................

Pituitary Gland + + 27.........................................................................................................................................................................................................

Thyroid Gland + + 26Ectopic Thymus 1


Tissue NOS 1Mediastinum, Abscess 1 4.0Mediastinum, Foreign Body 1

GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + + 27Degeneration 1 3.0

.........................................................................................................................................................................................................

Ovary + + 26Cyst 1 2.0Pigmentation 1 2.0

.........................................................................................................................................................................................................





DAY ON TEST0332

0292

.................................................................................................................................................................



00555

00674 * TOTALS


Uterus + + 27Edema 1 3.0Infiltration Cellular, Polymorphonuclear 3 2.0Endometrium, Hyperplasia, Cystic 1 5 1.6Lumen, Dilatation 8 1.3

.........................................................................................................................................................................................................

Vagina + A 24


Bone Marrow + + 26Myeloid Cell, Hyperplasia 1 2.0

.........................................................................................................................................................................................................

Lymph Node + 3Lumbar, Hyperplasia, Lymphoid 1 2.0

.........................................................................................................................................................................................................

Lymph Node, Mandibular + A 26.........................................................................................................................................................................................................


.........................................................................................................................................................................................................

Spleen + + 27Hematopoietic Cell Proliferation 8 3.0Hyperplasia, Lymphoid 6 1.8

.........................................................................................................................................................................................................

Thymus + + 27Hyperplasia, Lymphoid 2 2.0Inflammation, Chronic Active 1 3.0





DAY ON TEST0332

0292

.................................................................................................................................................................



00555

00674 * TOTALS



Mammary Gland + + 27.........................................................................................................................................................................................................

Skin + + 27


Bone 1.........................................................................................................................................................................................................

Bone, Femur + + 27.........................................................................................................................................................................................................


NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain, Brain Stem + + 27.........................................................................................................................................................................................................


Brain, Cerebrum + + 27Compression 1 2.0Mineralization 2 1.0





DAY ON TEST0332

0292

.................................................................................................................................................................



00555

00674 * TOTALS



Lung + + 27Abscess 4 1 4.0Foreign Body 1Inflammation, Chronic Active 1 3.0Necrosis 1 2.0

.........................................................................................................................................................................................................

Nose + + 27.........................................................................................................................................................................................................

Trachea + + 27


Eye + A 24.........................................................................................................................................................................................................

Harderian Gland + A 25

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + 27Casts Protein 2 1.0Cyst 1 1.0Glomerulosclerosis 3 1 3.0Infiltration Cellular, Lymphocyte 4 1.0Nephropathy 3 1 3.0





DAY ON TEST0332

0292

.................................................................................................................................................................



00555

00674 * TOTALS


.........................................................................................................................................................................................................

Urinary Bladder + + 26Infiltration Cellular, Lymphocyte 1 1.0





DAY ON TEST0332

0292

.................................................................................................................................................................



00555

00674 * TOTALS



Esophagus + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Gallbladder + + + + + + + + + + + + + + A + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + A + + + + + + + + + +Hyperplasia, Lymphoid 2 2 2

.........................................................................................................................................................................................................

Intestine Large, Colon + + + + + + + + + + + + + + A + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Rectum + + + + + + + + + + + + + + A + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Duodenum + + + + + + + + + + + + + + A + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Ileum + + + + + + + + + + + + + + A + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Small, Jejunum + + + + + + + + + + + + + + A + + + + + + + + + +.........................................................................................................................................................................................................

Liver + + + + + + + + + + + + + + A + + + + + + + + + +Infiltration Cellular, Lymphocyte 1 1Inflammation, Chronic Active 1 1Tension Lipidosis 1 1 2Vacuolization Cytoplasmic 1 1 1 1 1 1 1 1 1 1 1

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +





DAY ON TEST0335

0335

0335

0335

0334

0334

0335

0335

0335

0335

0332

0332

0331

0331

0273

0334

0334

0334

0334

0332

0332

0334

0333

0333

0336

.................................................................................................................................................................


ANIMAL IDVehicl PND1-8 F

00569

00570

00571

00572

00573

00579

00589

00590

00591

00592

00601

00602

00603

00604

00608

00619

00620

00621

00622

00623

00624

00627

00636

00637

00649

females(cont...)


.........................................................................................................................................................................................................

Salivary Glands + + + + + + + + + + + + + + A + + + + + + + + + +Infiltration Cellular, Lymphocyte 1 1 1 1 1 1 2 2 1 1 1 1 1 1

.........................................................................................................................................................................................................

Stomach, Forestomach + + + + + + + + + + + + + + A + + + + + + + + + +.........................................................................................................................................................................................................

Stomach, Glandular + + + + + + + + + + + + + + A + + + + + + + + + +


Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + A + + + + + + + + + +



.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................


Parathyroid Gland + + + + + + + + + M + + + + + + + + + + + + + + +.........................................................................................................................................................................................................





DAY ON TEST0335

0335

0335

0335

0334

0334

0335

0335

0335

0335

0332

0332

0331

0331

0273

0334

0334

0334

0334

0332

0332

0334

0333

0333

0336

.................................................................................................................................................................



00569

00570

00571

00572

00573

00579

00589

00590

00591

00592

00601

00602

00603

00604

00608

00619

00620

00621

00622

00623

00624

00627

00636

00637

00649

females(cont...)


Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +Ectopic Thymus X X


GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Ovary + + + + + + + + + + + + + + + + + + + + + + + + +Cyst 2 2 2

.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Polymorphonuclear 2Endometrium, Hyperplasia, Cystic 2 1 2Lumen, Dilatation 2 2 1 1 1 2 1 2 2 1 2 2 2 1 1 1

.........................................................................................................................................................................................................

Vagina + + + + + + + + + + + + + + + + + + + + + + + + +


Bone Marrow + + + + + + + + + + + + + + A + + + + + + + + + +.........................................................................................................................................................................................................





DAY ON TEST0335

0335

0335

0335

0334

0334

0335

0335

0335

0335

0332

0332

0331

0331

0273

0334

0334

0334

0334

0332

0332

0334

0333

0333

0336

.................................................................................................................................................................



00569

00570

00571

00572

00573

00579

00589

00590

00591

00592

00601

00602

00603

00604

00608

00619

00620

00621

00622

00623

00624

00627

00636

00637

00649

females(cont...)


Lymph Node, Mandibular + + + + + + + + + + + + + + A + + + + + + + + + +.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + A + + + + + + + + + +Hyperplasia, Lymphoid 1 2 1 2

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Hematopoietic Cell Proliferation 4 2Hyperplasia, Lymphoid 2 2 3 3 2 2

.........................................................................................................................................................................................................

Thymus + + + + + + + + + + + + + + A + + + + + + + + + +Hyperplasia, Lymphoid 2


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + +


Bone, Femur + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Skeletal Muscle + + + + + + + + + + + + + + + + + + + + + + + + +

NERVOUS SYSTEM





DAY ON TEST0335

0335

0335

0335

0334

0334

0335

0335

0335

0335

0332

0332

0331

0331

0273

0334

0334

0334

0334

0332

0332

0334

0333

0333

0336

.................................................................................................................................................................



00569

00570

00571

00572

00573

00579

00589

00590

00591

00592

00601

00602

00603

00604

00608

00619

00620

00621

00622

00623

00624

00627

00636

00637

00649

females(cont...)


.........................................................................................................................................................................................................

Brain, Brain Stem + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................


Brain, Cerebrum + + + + + + + + + + + + + + + + + + + + + + + + +Mineralization 1 1


Lung + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +


Eye + + + + + + + + + + + + + + A + + + + + + + + + +.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + A + + + + + + + + + +

URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + A + + + + + + + + + +





DAY ON TEST0335

0335

0335

0335

0334

0334

0335

0335

0335

0335

0332

0332

0331

0331

0273

0334

0334

0334

0334

0332

0332

0334

0333

0333

0336

.................................................................................................................................................................



00569

00570

00571

00572

00573

00579

00589

00590

00591

00592

00601

00602

00603

00604

00608

00619

00620

00621

00622

00623

00624

00627

00636

00637

00649

females(cont...)


Infiltration Cellular, Lymphocyte 1 1 1 1 1 2 1 1.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + A + + + + + + + + + +Infiltration Cellular, Lymphocyte 1 1Lumen, Dilatation 4





DAY ON TEST0335

0335

0335

0335

0334

0334

0335

0335

0335

0335

0332

0332

0331

0331

0273

0334

0334

0334

0334

0332

0332

0334

0333

0333

0336

.................................................................................................................................................................



00569

00570

00571

00572

00573

00579

00589

00590

00591

00592

00601

00602

00603

00604

00608

00619

00620

00621

00622

00623

00624

00627

00636

00637

00649

females(cont...)



Esophagus + 26.........................................................................................................................................................................................................

Gallbladder + 25.........................................................................................................................................................................................................


.........................................................................................................................................................................................................






Liver + 25Infiltration Cellular, Lymphocyte 2 1.0Inflammation, Chronic Active 2 1.0Tension Lipidosis 3 1.3Vacuolization Cytoplasmic 1 12 1.0

.........................................................................................................................................................................................................

Pancreas + 26





DAY ON TEST0335

.................................................................................................................................................................



00654 * TOTALS


.........................................................................................................................................................................................................


.........................................................................................................................................................................................................




Blood Vessel + 26.........................................................................................................................................................................................................

Heart + 25


Adrenal Cortex + 26Subcapsular, Hyperplasia 23 1.2

.........................................................................................................................................................................................................

Adrenal Medulla + 26.........................................................................................................................................................................................................







DAY ON TEST0335

.................................................................................................................................................................



00654 * TOTALS


Pituitary Gland + 26.........................................................................................................................................................................................................

Thyroid Gland + 26Ectopic Thymus 2


GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + 26.........................................................................................................................................................................................................

Ovary + 26Cyst 3 4 2.3

.........................................................................................................................................................................................................

Uterus + 26Infiltration Cellular, Polymorphonuclear 1 2.0Endometrium, Hyperplasia, Cystic 1 4 1.5Lumen, Dilatation 16 1.5

.........................................................................................................................................................................................................

Vagina + 26


Bone Marrow + 25.........................................................................................................................................................................................................





DAY ON TEST0335

.................................................................................................................................................................



00654 * TOTALS


Lymph Node, Mandibular + 25.........................................................................................................................................................................................................


.........................................................................................................................................................................................................


.........................................................................................................................................................................................................

Thymus + 25Hyperplasia, Lymphoid 1 2.0


Mammary Gland + 26.........................................................................................................................................................................................................

Skin + 26


Bone, Femur + 26.........................................................................................................................................................................................................


NERVOUS SYSTEM





DAY ON TEST0335

.................................................................................................................................................................



00654 * TOTALS


.........................................................................................................................................................................................................

Brain, Brain Stem + 26.........................................................................................................................................................................................................


Brain, Cerebrum + 26Mineralization 2 1.0


Lung + 26.........................................................................................................................................................................................................

Nose + 26.........................................................................................................................................................................................................

Trachea + 26


Eye + 25.........................................................................................................................................................................................................


URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + 25





DAY ON TEST0335

.................................................................................................................................................................



00654 * TOTALS


Infiltration Cellular, Lymphocyte 1 9 1.1.........................................................................................................................................................................................................

Urinary Bladder + 25Infiltration Cellular, Lymphocyte 2 1.0Lumen, Dilatation 1 4.0





DAY ON TEST0335

.................................................................................................................................................................



00654 * TOTALS



Esophagus + + + + + + + + + + + + + + M + + + + + + + + + +.........................................................................................................................................................................................................

Gallbladder + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Intestine Large, Cecum + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................






Liver + + + + + + + + + + + + + + + + + + + + + + + + +Basophilic Focus XInfiltration Cellular, Lymphocyte 1Tension Lipidosis 1 1 2 2Vacuolization Cytoplasmic 1 1 1 1 1 1

.........................................................................................................................................................................................................

Pancreas + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................





DAY ON TEST0245

0308

0334

0334

0334

0334

0334

0334

0334

0332

0332

0332

0332

0332

0274

0336

0335

0333

0333

0332

0332

0332

0331

0331

0336

.................................................................................................................................................................


ANIMAL IDAZT 40 PND1-8 F

00390

00556

00559

00560

00561

00562

00563

00583

00584

00594

00595

00596

00606

00607

00610

00613

00638

00639

00640

00641

00642

00650

00658

00659

00666

females(cont...)


Salivary Glands + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1 1 2 2 1 1 1 1 1 1 1

.........................................................................................................................................................................................................




Blood Vessel + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Heart + + + + + + + + + + + + + + + + + + + + + + + + +



.........................................................................................................................................................................................................

Adrenal Medulla + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................


Parathyroid Gland M + + + + + + + + + + + M + + + + + + + + + + + +.........................................................................................................................................................................................................

Pituitary Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................





DAY ON TEST0245

0308

0334

0334

0334

0334

0334

0334

0334

0332

0332

0332

0332

0332

0274

0336

0335

0333

0333

0332

0332

0332

0331

0331

0336

.................................................................................................................................................................



00390

00556

00559

00560

00561

00562

00563

00583

00584

00594

00595

00596

00606

00607

00610

00613

00638

00639

00640

00641

00642

00650

00658

00659

00666

females(cont...)


Thyroid Gland + + + + + + + + + + + + + + + + + + + + + + + + +Degeneration 1Ectopic Thymus X


GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + + + + + + + + + + + M + + + + + + + + + + + + +.........................................................................................................................................................................................................

Ovary + + + + + + + + + + + + + + + + + + + + + + + + +Cyst 2

.........................................................................................................................................................................................................

Uterus + + + + + + + + + + + + + + + + + + + + + + + + +Endometrium, Hyperplasia, Cystic 2 2 1Lumen, Dilatation 1 1 1 1 1 1 1 1 1 2 1 2 2

.........................................................................................................................................................................................................

Vagina + + + + + + + + + + + + + M + + + + + + + + + + +


Bone Marrow + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Lymph Node + +Renal, Hyperplasia, Lymphoid 1





DAY ON TEST0245

0308

0334

0334

0334

0334

0334

0334

0334

0332

0332

0332

0332

0332

0274

0336

0335

0333

0333

0332

0332

0332

0331

0331

0336

.................................................................................................................................................................



00390

00556

00559

00560

00561

00562

00563

00583

00584

00594

00595

00596

00606

00607

00610

00613

00638

00639

00640

00641

00642

00650

00658

00659

00666

females(cont...)


.........................................................................................................................................................................................................

Lymph Node, Mandibular + + + + + + M + + + + + + + + + + + + + + + + + +Hyperplasia, Lymphoid 1

.........................................................................................................................................................................................................

Lymph Node, Mesenteric + + + + + + + + + + + + + + + + + + + + + + + + +Hyperplasia, Lymphoid 1 1 1

.........................................................................................................................................................................................................

Spleen + + + + + + + + + + + + + + + + + + + + + + + + +Hematopoietic Cell Proliferation 2 2Hyperplasia, Lymphoid 3 2 2 2 3 1

.........................................................................................................................................................................................................

Thymus + + + + + + + + M + + + + + + + + + + + + + + + +Cyst, Multiple 4Hyperplasia, Lymphoid 1 2 1


Mammary Gland + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Skin + + + + + + + + + + + + + + + + + + + + + + + + +


Bone, Femur + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Skeletal Muscle + + + + + + + + + + + + + + + + + + + + + + + + +





DAY ON TEST0245

0308

0334

0334

0334

0334

0334

0334

0334

0332

0332

0332

0332

0332

0274

0336

0335

0333

0333

0332

0332

0332

0331

0331

0336

.................................................................................................................................................................



00390

00556

00559

00560

00561

00562

00563

00583

00584

00594

00595

00596

00606

00607

00610

00613

00638

00639

00640

00641

00642

00650

00658

00659

00666

females(cont...)


NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain, Brain Stem + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................


Brain, Cerebrum + + + + + + + + + + + + + + + + + + + + + + + + +Mineralization 1 1 1 1


Lung + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 2Inflammation, Chronic Active 1

.........................................................................................................................................................................................................

Nose + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Trachea + + + + + + + + + + + + + + + + + + + + + + + + +


Eye + + + + + + + + + + + + + + + + + + + + + + + + +.........................................................................................................................................................................................................

Harderian Gland + + + + + + + + + + + + + + + + + + + + + + + + +





DAY ON TEST0245

0308

0334

0334

0334

0334

0334

0334

0334

0332

0332

0332

0332

0332

0274

0336

0335

0333

0333

0332

0332

0332

0331

0331

0336

.................................................................................................................................................................



00390

00556

00559

00560

00561

00562

00563

00583

00584

00594

00595

00596

00606

00607

00610

00613

00638

00639

00640

00641

00642

00650

00658

00659

00666

females(cont...)


URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1 1 1 1 1

.........................................................................................................................................................................................................

Urinary Bladder + + + + + + + + + + + + + + + + + + + + + + + + +Infiltration Cellular, Lymphocyte 1 1





DAY ON TEST0245

0308

0334

0334

0334

0334

0334

0334

0334

0332

0332

0332

0332

0332

0274

0336

0335

0333

0333

0332

0332

0332

0331

0331

0336

.................................................................................................................................................................



00390

00556

00559

00560

00561

00562

00563

00583

00584

00594

00595

00596

00606

00607

00610

00613

00638

00639

00640

00641

00642

00650

00658

00659

00666

females(cont...)



Esophagus + 25.........................................................................................................................................................................................................

Gallbladder + 26.........................................................................................................................................................................................................

Intestine Large, Cecum + 26.........................................................................................................................................................................................................






Liver + 26Basophilic Focus 1Infiltration Cellular, Lymphocyte 1 1.0Tension Lipidosis 4 1.5Vacuolization Cytoplasmic 6 1.0

.........................................................................................................................................................................................................

Pancreas + 26.........................................................................................................................................................................................................





DAY ON TEST0336

.................................................................................................................................................................



00667 * TOTALS



.........................................................................................................................................................................................................




Blood Vessel + 26.........................................................................................................................................................................................................

Heart + 26


Adrenal Cortex + 26Subcapsular, Hyperplasia 1 24 1.1

.........................................................................................................................................................................................................

Adrenal Medulla + 26.........................................................................................................................................................................................................



Pituitary Gland + 26.........................................................................................................................................................................................................





DAY ON TEST0336

.................................................................................................................................................................



00667 * TOTALS


Thyroid Gland + 26Degeneration 1 1.0Ectopic Thymus 1


GENITAL SYSTEM.........................................................................................................................................................................................................

Clitoral Gland + 25.........................................................................................................................................................................................................

Ovary + 26Cyst 1 2.0

.........................................................................................................................................................................................................

Uterus + 26Endometrium, Hyperplasia, Cystic 3 1.7Lumen, Dilatation 13 1.2

.........................................................................................................................................................................................................

Vagina + 25


Bone Marrow + 26.........................................................................................................................................................................................................

Lymph Node 2Renal, Hyperplasia, Lymphoid 1 1.0





DAY ON TEST0336

.................................................................................................................................................................



00667 * TOTALS


.........................................................................................................................................................................................................

Lymph Node, Mandibular + 25Hyperplasia, Lymphoid 1 1.0

.........................................................................................................................................................................................................


.........................................................................................................................................................................................................


.........................................................................................................................................................................................................

Thymus + 25Cyst, Multiple 1 4.0Hyperplasia, Lymphoid 3 1.3


Mammary Gland + 26.........................................................................................................................................................................................................

Skin + 26


Bone, Femur + 26.........................................................................................................................................................................................................






DAY ON TEST0336

.................................................................................................................................................................



00667 * TOTALS


NERVOUS SYSTEM.........................................................................................................................................................................................................

Brain, Brain Stem + 26.........................................................................................................................................................................................................


Brain, Cerebrum + 26Mineralization 4 1.0


Lung + 26Infiltration Cellular, Lymphocyte 1 2.0Inflammation, Chronic Active 1 1.0

.........................................................................................................................................................................................................

Nose + 26.........................................................................................................................................................................................................

Trachea + 26


Eye + 26.........................................................................................................................................................................................................






DAY ON TEST0336

.................................................................................................................................................................



00667 * TOTALS


URINARY SYSTEM.........................................................................................................................................................................................................

Kidney + 26Infiltration Cellular, Lymphocyte 5 1.0

.........................................................................................................................................................................................................

Urinary Bladder + 26Infiltration Cellular, Lymphocyte 1 3 1.0

*** END OF REPORT ***





DAY ON TEST0336

.................................................................................................................................................................



00667 * TOTALS


ntp.niehs.nih.gov...tdms no. 20310 - 01 p09: non-neoplastic lesions by individual animal date report...

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