2005

CarbohydratesU 0500 Novel Method for the Synthesis of 3',4'-Dideoxygenated Pyranmycin and Kana-

mycin Compounds, and Studies of Their Antibacterial Activity Against Aminogly-coside-Resistant Bacteria. — A novel protocol for transforming a trans-diol to an al-kene under mild conditions is developed and applied to the synthesis of a 3',4'-dide-oxykanamycin analogue (I) and a 3',4'-dideoxypyranmycin (II). Both compounds are found to be active against aminoglycoside-resistant bacteria. — (RAI, R.; CHEN, H.-N.; CHANG, H.; CHANG*, C.-W. T.; J. Carbohydr. Chem. 24 (2005) 2, 131-143; Dep. Chem. Biochem., Utah State Univ., Logan, UT 84322, USA; Eng.) —H. Toeppel

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