novel biocompatible inorganic-organic hybrid nanomaterials
TRANSCRIPT
POSTER10.1002/zaac.201204107
Novel Biocompatible Inorganic-Organic Hybrid Nanomaterials
Joachim Heck[a] and Claus Feldmann*[a]
Keywords: luminescence, nanomaterial, inorganic-organichybrid material
Optical imaging has emerged as a powerful modality for vis-ualizing whole organisms or single cells (e.g. tumor cells) inlife science.[1] In particular for in vivo application, new bioc-ompatible contrast agents are required. As a first example of anew class of inorganic-organic hybrid nanomaterials,ZrO(FMN) (FMN: flavin mononucleotide) shows high bioc-ompatibility and is easy accessible by a water-based syn-thesis.[2] The dye anion is responsible for bright green emis-sion of the nanoparticles under UV and blue-light excitation(Figure 1). Aim of this work is to expand the existing conceptsof dye-modified zirconium phosphates to red and infrared em-ission in order to avoid autofluorescence.
Figure 1. ZrO(FMN) with a) its formal constituents as well as exci-tation and emission spectra; b) Suspensions of as-prepared nanopart-icles.[2]
[1] J. G. Fujimoto, D. Farkas, in: Biomedical Optical Imaging, OxfordUniversity Press, Oxford, 2009.
[2] M. Roming, H. Lünsdorf, K. E. J. Dittmar, C. Feldmann, Angew.Chem. Int. Ed. 2010, 49, 632–637.
* Prof. Dr. C. FeldmannE-Mail: [email protected]
[a] Institut für Anorganische Chemie, Karlsruher Institut fürTechnologie (KIT), Engesserstr. 15, 76131 Karlsruhe, Germany
www.zaac.wiley-vch.de © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Z. Anorg. Allg. Chem. 2012, 1567–16411620
10.1002/zaac.201204108
Microwave-Assisted Synthesis ofLuminescent Nanophosphates
Ana Kuzmanoski[a] and Claus Feldmann*[a]
Keywords: Luminescent nanomaterials, Ionic Liquids
Creating high-quality luminescent nanomaterials requires thatnumerous parameters, involving particle core and surface, col-loidal properties, and particle deposition, are taken into con-sideration during synthesis.[1] Besides the particle size, highcristallinity, no quenching and high quantum yield are pre-requisite to the luminescent properties. New applications ofnanoscale phosphors include transparent luminescent layers ormarkers, luminescent fillers in transparent matrices, as well asbiomedical application such as fluorescence resonance energytransfer assays, bio-labeling, optical imaging, or photother-apy.[2]
In recent years, ionic liquids (ILs), as reaction media haveopened new properties in various synthesis techniques of dif-ferent nanomaterials (for example, microwave-assisted syn-thesis of LaPO4:Ce,Tb nanocrystals[1] or low-temperature syn-thesis of nanophosphates[3]). The main advantages of ILs (highnucleation rate, excellent electrosteric NP stabilization, mor-phology control, tunable properties) play the key roles ingrowth of nanoparticles.Herein, we present a facile and fast synthesis of uniform lan-thanide phosphates nanoparticles as the host matrix, dopedwith optically active lanthanide ions (Ce3+, Tb3+, Eu3+). Toobtain high-quality luminescent nanoparticles, the synthesiswas performed in a microwave, by rapid heating over a shorttime interval, in properly designed system, containing ionicliquids. From this method we can obtain different nanophos-phates in a range of 17–50 nm, with very bright emission underUV- and blue-light excitation. Moreover, this straightforwardapproach might also be applicable for the synthesis of otherluminescent nanophosphates.
[1] G. Bühler, C. Feldmann, Angew. Chem. 2006, 118, 4982; Angew.Chem. Int. Ed. 2006, 45, 4864.
[2] R. C. Somers, M. G. Bawendi, D.G. Nocera, Chem. Soc. Rev. 2007,36, 579.
[3] J. Cybinska, C. Lorbeer, E. Zych, A.-V. Mudring, ChemSusChem2011, 4, 595.
* Prof. Dr. C. FeldmannE-Mail: [email protected]
[a] Institute for Inorganic Chemistry, Karlsruhe Institute ofTechnology, Engesserstr. 15, 76131 Karlsruhe, Germany