Non-Specific Immune Response

• How Cells recognise each other.• The role of Inflammation• Phagocytosis• Cell response to Viruses

Key Terms: Antigens, Histamine, Mast Cells, Oedema, Fever, Phagocytosis, Granulocytes, Agranulocytes, Interferons

The immune response

Cell Recognition

Peripheral proteins on the extracellular side of the membrane act as receptors for hormones or neurotransmitters, or are involved in cell recognition. Many are glycoproteins.

Non-specific immune responseThe non-specific or innate immune response quickly targets a wide range of pathogens and foreign substances. Phagocytosis, inflammation and the antimicrobial proteins lysozyme and interferons are all part of this immune response. Lysozyme is an enzyme that disrupts the cell walls of gram-

positive bacteria by digesting the peptidoglycan. It is found in human tears, saliva and lysosomes.

Interferons are proteins produced by virus-infected body cells in response to the virus. Interferons trigger the production of a second protein that inhibits viral replication by binding to mRNA coded by the virus.

What happens during Inflammation & Phagocytosis?

Phagocytosis

Phagocytosis Animations

McGraw-Hill• http://

www.youtube.com/watch?v=7VQU28itVVw

A Musical Interpretation!• http://

www.youtube.com/watch?v=VAhM9OxZDkU

Activities

1) Read and highlight both sides of the information sheet and add detail to your notes on Inflammation and Phagocytosis.

2) Use this and pages 97 -99 in your textbook to work through the activities on: ‘Phagocytosis & other Non-Specific Responses’

Non-specific immunity: true or false?