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    Non Invasive VentilationNon Invasive VentilationNon Invasive VentilationNon Invasive Ventilation

    Dr.Balamugesh, MD, DM,

    Dept. of Pulmonary Medicine,Christian Medical College,

    Vellore.

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    Definition..Definition..

    Noninvasive ventilation is the delivery of

    ventilatory support without the need for an

    invasive artificial airway

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    How does NIV work?How does NIV work?

    Reduction in inspiratory muscle workand avoidance of respiratory musclefatigue

    Tidal volume is increased CPAP counterbalances the inspiratory

    threshold work related to intrinsicPEEP.

    NIV improves respiratory systemcompliance by reversingmicroatelectasis of the lung.

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    Advantages ofNIVAdvantag

    es ofNIV

    Noninvasiveness

    Application (compared with endotracheal intubation)

    a.Easy to implement b. Easy to remove Allows

    intermittent application

    Improves patient comfort

    Reduces the need for sedationOral patency (preserves speech, swallowing, and

    cough, reduces the need for nasoenteric tubes)

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    Avoid the resistive work imposed by the

    endotracheal tube

    Avoids the complications of endotracheal

    intubation

    Early (local trauma, aspiration)

    Late (injury to the the hypopharynx, larynx, andtrachea, nosocomial infections)

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    Disadvantages ofNIVDisadvantages ofNIV

    1.System

    Slower correction of gas exchange abnormalities

    Increased initial time commitment

    Gastric distension (occurs in

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    3.Lack of airway access and protection

    Suctioning of secretions

    aspiration

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    Location of NIVLocation of NIV

    NIV can be administered in the emergencydepartment, intermediate care unit, or generalrespiratory ward

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    Who can administer NIV?Who can administer NIV?

    by physicians, nurses, or respiratory caretherapists,

    depends on staff experience and availabilityof resources for monitoring, and managingcomplications

    For the first few hours, one-to-one monitoringby a skilled and experienced nurse,

    respiratory therapist, or physician ismandatory.

    Immediate access to staff skilled in invasiveairway management.

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    InterfaceInterface

    Nasal masks

    less dead space

    less claustrophobia

    allow for expectoration

    vomiting and oral intake

    vocalize

    facial mask

    dyspnoeic patients

    are usually mouthbreathers

    More dead space

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    Mask: orofacial vs nasalMask: orofacial vs nasal

    similar with regard toimproving vital signs and gas

    exchange and avoidingintubation

    nasal mask was less well

    tolerated mainly due togreater air leakagethrough mouth Crit Care Med. 2003 Feb;31

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    Helmet vs facial

    mask

    Helmet vs facial

    mask

    Complications (skin necrosis,

    gastric distension, and eye

    irritation) were fewer with

    helmet

    allowed prolonged continuous

    application ofNIV

    Length of stay in ICU,intubation rates, mortality

    similar

    Intensive Care Med. 2003;29 CritCare Med. 2002;30

    Chest. 2004;126

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    Position of exhalation port and mask design

    affect CO2 rebreath

    ing during NIV

    Position of exhalation port and mask design

    affect CO2 rebreath

    ing during NIV

    facial mask with exhalation port within the

    mask compared with port in the ventilatorcircuit

    smallest mask volume

    less rebreathed CO2

    inspiratory load

    Crit Care Med. 2003 Aug;31

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    Humidification during NIVHumidification during NIV

    No humidification: drying of nasal mucosa;

    increased airway resistance; decreased

    compliance.

    HME lessens the efficacy ofNIV

    Only pass-over humidifiers should be

    used

    Intensive Care Med. 2002;28

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    Aerosol bronchodilator delivery during NIVAerosol bronchodilator delivery during NIV

    optimum nebulizer position: between the leak port and

    patient connection

    Optimum ventilator settings: high inspiratory pressure

    and low expiratory pressure.

    Optimum RR 20/mt. Rather than 10/mt. 25% of salbutamol dose may be delivered

    Crit Care Med. 2002 Nov;30

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    Desirable to deliver the aerosolizedbronchodilator without removing the

    patient from NIV ? aerosol delivery in systems in which

    the leak port is in the mask or in which aleak port of different design

    ? Nebulizer was maintained in thevertical position

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    Uses of NIVUses of NIV1. COPD. Acute exacerbation/domiciliary.

    2. Cardiogenic pulmonary edema.

    3. Bronchial asthma

    4. Post extubation RF

    5. Hasten weaning.

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    COPD EXACERBATION: NIVCOPD EXACERBATION: NIV success rates of 80-85%

    increases pH, reduces PaCO2, reduces

    the severity of breathlessness in first 4 h

    of treatment

    decreases the length of hospital stay

    Mortality, intubation rateis reduced

    GOLD 2003

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    CRITERIA FOR NIV IN ACUTE

    EXACERBATION OF COPD

    CRITERIA FOR NIV IN ACUTE

    EXACERBATION OF COPD GOLD 2005

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    Cardiogenic Pulmonary edema.Cardiogenic Pulmonary edema. sufficiently high level evidence to favor the

    use of CPAP,

    there is insufficient evidence to recommend

    the use of BiPAP, probably the exception

    being patients with hypercapnic CPE.

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    MethodologyMethodology

    Initial ventilator settings: CPAP (EPAP) 2 cmH2O & PSV (IPAP) 5 cm H20.

    Mask is held gently on patients face. Increase the pressures until adequate Vt

    (7ml/kg), RR90%. Keep peak pressure

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    MonitoringMonitoring

    ResponsePhysiological a) Continuous oximetry

    b) Exhaled tidal volume

    c) ABG should be obtained with 1 hour and, asnecessary, at 2 to 6 hour intervals.

    Objective a) Respiratory rateb) blood pressure

    c) pulse rate

    Subjectivea) dyspneab) comfort

    c) mental alertness

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    Monitoring..Monitoring..Mask

    Fit, Comfort, Air leak, Secretions, Skin necrosis

    Respiratory muscle unloading

    Accessory muscle activity, paradoxical

    abdominal motion

    Abdomen

    Gastric distension

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    First 30 min. of NPPV is labor intensive.

    Bedside presence of a

    respiratory therapist or nurse

    familiar with this mode is essential.Providing reassurance and adequate explanation

    Be ready to intubate andstart on invasive

    ventilation.

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    Criteria to discontinue NIVCriteria to discontinue NIV Inability to tolerate the mask because of discomfort or

    pain

    Inability to improve gas exchange or dyspnea Need for endotracheal intubation to manage secretions

    or protect airway

    Hemodynamic instability

    ECG ischemia/arrhythmia Failure to improve mental status in those with CO2

    narcosis.

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    Eur Respir J 2002; 20: