Leslie Raffel, MDAssociate Director and Cedars-Sinai Site Director, UCLA Clinical & Translational Science Institute

NIH/ Career Development Award WorkshopFebruary 13, 2014

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UCLA CTSI Clinical and Translational Science Institute

www.ctsi.ucla.edu

Create an academic home for translational science

Advance team science

Train the next generation of translational scientists

Build bi-directional community partnerships

Promote inter-institutional collaborations

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UCLA CTSI Goals

NIH CTSA Consortium

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UCLA CTSI translational investigation extends from molecules to society

Translating knowledge gained from laboratory science into clinical practice to improve health.

The aim of translational research is to produce new:

• therapeutics• medical devices• tools for diagnosing disease• avenues for community engagement research

What is translational research?

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1) Clinical and Community Research Resources (CCRR)

2) Biomedical Informatics Program (BIP)

3) Community Engagement in Research Program (CERP)

4) Pilot and Collaborative Translational and Clinical Studies Programs (Pilot)

5) Research Education, Training and Career Development Program (CTSI-ED)

Program Areas (1-5)

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6) Biostatistics and Computational Biology Program

7) Center for Translational Technologies (CTT)

8) Maternal, Child and Adolescent Health (MCAH)

9) Regulatory Knowledge, Industry Relations and Research Ethics Program (Regulatory)

10) Evaluation & Tracking

Program Areas (6-10)

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Opportunity Funds Grant Amount

Duration of Award (Years)

Award Cycle

Application Due Date

KL2 Awards: to pursue interdisciplinary, mentored research with training

Up to $125,000 in salary and

research support

1 year at 75% effort(renewable for up to 3

years)

July 1 Full application: February 24, 2014

TL1 Translational Science Fellowship: PhD candidates in the Department of Health Policy and Management in the UCLA Fielding School of Public Health receive mentored training to ensure the translational nature of their dissertation projects

Annual stipend plus funding for

health insurance,

tuition/fees, and training-related

travel

Renewable for up to 4

years

Annual UCLA School of Public Health application

deadline was Dec 1, 2014

TL1 Summer Program for Professional Students: provides professional students (medical, nursing and dental) early exposure to interdisciplinary, community-partnered translational or health services research

Summer stipend plus funding for training-related

expenses

The summer between

student’s first and second

year (8 weeks)

June 1 March 28, 2014

Early Career Awards

Assistant Professor, CDU

“ Effects of Varenicline on Alcohol and Nicotine Consumption and changes in Dopamine D2-like Receptor Availability in High-Alcohol Preferring Mice”

Amira Brown, MS, PhDAmira Brown, MS, PhD

Assistant Professor, Pediatric Nephrology, UCLA

“ Hepcidin and the Anemia of Chronic Kidney Disease”

Joshua Zaritsky, MD, PhDJoshua Zaritsky, MD, PhD

Assistant Professor of Medicine, UCLA/VA

“ Patterns and Predictors of Poor Outcomes Following Emergency Department Discharge in Older Adults”

Gelareh Gabayan, MD, MSHSGelareh Gabayan, MD, MSHS

KL2 Y1 Awardees

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Assistant Professor, UCLA-Harbor / LA-BioMed

“Using Research in Vancomycin-Resistant Enterococcus to Validate an Efficient System of Quantifying Antibiotic Utilization”

James McKinnell, MDJames McKinnell, MD

Assistant Professor, UCLA

“Modeling of EMT/MET transitions in breast cancer stem cells”

Mary Sehl, MD, PhDMary Sehl, MD, PhD

Assistant Professor, UCLA

“Development of novel therapeutic strategies to target LKB1/STK11 deficient non-small cell lung cancer”

David Shackelford, PhDDavid Shackelford, PhD

KL2 Y2 Awardees

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Assistant Professor, UCLA

“Understanding the relationship between adolescent identity and substance use”

Rebecca Dudovitz, MD, MSHSRebecca Dudovitz, MD, MSHS

Assistant Clinical Professor, Cedars-Sinai Medical Center

“Role of IL1-ß and the NLRP3 inflammasome in the development of hypoxemia in acute lung injury”

Heather Jones, MDHeather Jones, MD

Assistant Professor, UCLA

“Single fraction vs. multiple fraction radiation for patients with advanced cancer and painful bone metastases”

Anne Walling, MD, PhDAnne Walling, MD, PhD

KL2 Y3 Awardees

Clinical Instructor, UCLA

“Mechanisms Of Allograft Injury And The Development Of Bronchiolitis Obliterans Syndrome After Lung Transplantation”

Michael Shino, MDMichael Shino, MD

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Assistant Clinical Professor, UCLA

“Relationship of physical activity to hippocampal structure and memory in MCI”

David Merrill, MD, PhDDavid Merrill, MD, PhD

Assistant Professor, UCLA

“Gene expression profiles of ECT response in major depressive disorder”

Eliza Congdon, PhDEliza Congdon, PhD

Assistant Professor, Cedars-Sinai Medical Center

“Minimizing errors in medication histories obtained at hospital admission”

Joshua Pevnick, MD, MSHSJoshua Pevnick, MD, MSHS

KL2 Y3 Awardees

Assistant Professor, Charles Drew University of Medicine and Science

“Sensitization of castration-resistant prostate tumors to docetaxel treatment by green tea and quercetin”

Piwen Wang, MD, PhD, MSPiwen Wang, MD, PhD, MS

The CTRC at Cedars-Sinai

Supports and supervises human studies and clinical trials in all therapeutic areas and within all age groups

•5 exam/consultation rooms

•Bionutritionist

•Sample processing laboratory

•Experienced certified research nurses

•Mobile nurses

•Cost-sharing with reduced rates for new investigators

CTRC-Wide Accomplishments

•Clinical support for 426 new & existing projects

•9,048 out-patient & 5754 in-patient stays

Clinical and Translational Research Center (CTRC)

Biostatistics · Core Services · Pilot Funding · Education Activities

13banner “Cite It” card posters newsletters

Quarterly publication

awards

Biostatistical Consults• 8442 hours of statistical support provided

Vouchers•Awarded 79 proposals

Pilot funding•Awarded 73 pilot grants

($1.6 M in CTSI funds; $2.2 M institutional funds)

CTSI Education Activities•>90 participants in K Award Workshops•27 submitted draft proposals for review

More than 450 publications that received CTSI support

Watch for RFA coming soon!

14banner “Cite It” card newsletters

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