nice no longer recommends omalizumab for asthma .

PharmacoEconomics & Outcomes News 667 - 24 Nov 2012 NICE no longer recommends omalizumab for asthma . . . In a recent draft guidance, the UK NICE no longer recommends the use of omalizumab [Xolair] in adults with severe, persistent allergic asthma, reversing their 2007 guidance after reviewing newly available evidence. 1 NICE Chief Executive, Sir Andrew Dillon, says "it is not as clinically or cost-effective as first thought". Their recommendation of not using omalizumab in children is unchanged. The updated cost-effectiveness analysis included new mortality data and changes in cost effectiveness of the treatment because of changes in the dosing schedule for omalizumab but did not include potential benefits on health-related QOL, which were deemed by NICE as insufficient to alter their conclusions. NICE had also attempted to identify the patient population with very severe persistent asthma for whom omalizumab may be a cost effective treatment, but were unsuccessful. The next step is for the manufacturer to respond to the draft guidance. . . . and rejects vinflunine for bladder cancer Meanwhile, final draft guidance has been issued by NICE not recommending vinflunine [Javlor] for the treatment of advanced or metastatic transitional cell carcinoma of the urothelial tract that has progressed after platinum-based chemotherapy. 2 Despite an appeal from the manufacturer (Pierre Fabre) against the first ‘final appraisal determination’, the manufacturer’s evidence of the effectiveness of vinflunine was considered inconclusive by NICE, "particularly the extent to which it can prolong survival compared with best supportive care". 1. NICE. NICE consults on treatment for asthma in children and adults. Media Release : 8 Nov 2012. Available from: URL: http://www.nice.org.uk. 2. NICE. NICE issues further draft guidance on treatment for bladder cancer. Media Release : 8 Nov 2012. Available from: URL: http://www.nice.org.uk. 801085622 1 PharmacoEconomics & Outcomes News 24 Nov 2012 No. 667 1173-5503/10/0667-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved

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PharmacoEconomics & Outcomes News 667 - 24 Nov 2012

NICE no longer recommendsomalizumab for asthma . . .

In a recent draft guidance, the UK NICE no longerrecommends the use of omalizumab [Xolair] in adultswith severe, persistent allergic asthma, reversing their2007 guidance after reviewing newly availableevidence.1 NICE Chief Executive, Sir Andrew Dillon, says"it is not as clinically or cost-effective as first thought".Their recommendation of not using omalizumab inchildren is unchanged.

The updated cost-effectiveness analysis included newmortality data and changes in cost effectiveness of thetreatment because of changes in the dosing schedule foromalizumab but did not include potential benefits onhealth-related QOL, which were deemed by NICE asinsufficient to alter their conclusions. NICE had alsoattempted to identify the patient population with verysevere persistent asthma for whom omalizumab may bea cost effective treatment, but were unsuccessful. Thenext step is for the manufacturer to respond to the draftguidance.

. . . and rejects vinflunine for bladder cancerMeanwhile, final draft guidance has been issued by

NICE not recommending vinflunine [Javlor] for thetreatment of advanced or metastatic transitional cellcarcinoma of the urothelial tract that has progressedafter platinum-based chemotherapy.2 Despite an appealfrom the manufacturer (Pierre Fabre) against the first‘final appraisal determination’, the manufacturer’sevidence of the effectiveness of vinflunine wasconsidered inconclusive by NICE, "particularly theextent to which it can prolong survival compared withbest supportive care".1. NICE. NICE consults on treatment for asthma in children and adults. Media

Release : 8 Nov 2012. Available from: URL: http://www.nice.org.uk.2. NICE. NICE issues further draft guidance on treatment for bladder cancer.

Media Release : 8 Nov 2012. Available from: URL: http://www.nice.org.uk.801085622

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