nextstep nano-tera 2015
DESCRIPTION
Presentations of NextStep researchersTRANSCRIPT
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Drill integrated neuro-monitoring for minimally invasive robotic cochlear implantation> Background
Drill passes within 0.3 1 mm of facial nerve
> Facial nerve safety preliminary work Neuromonitoring for FN protection (detect FN proximity) Optimal stimulation protocol determined in sheep Custom neuromonitoring probe detects FN ( Project Goal Drill integrated stimulation for conitinuous FN monitoring
> Proposal Protocol verification in humans (medical grade EMG device
required) (Neurosign device, 17000 CHF ) Drill bit insulation coating for integrated stimulation
electrodes (Student 2.5 months ~ 14,000 CHF) Total budget 31,000 CHF, project duration 6 months
> Collaborators Marco Caversaccio, Department of ENT, Unibe Jorg Patscheider, Coatings department, Empa
Anode 1Anode 2Anode 3
Cathode
-1 0 10.10.30.5
1
1.5
Stim
ulus
thre
shol
d (m
A)
Axial distance (mm)
Sheep 2Trajectory 7LD = 0
d = 2d = 4d = 7Mono
FN
Juan Ans, May 2015
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NextStep - Scientific Collaboration04.05.2015 - Tobia Brusa, ISTB, University Bern
> Functional anatomy of Fecal Incontinence (FI) Characterization of continence organs anatomy and biomechanics in
patients suffering from fecal incontinence (FI). Prof. Dr. Med. Radu Tutuian, chief physician gastroenterology at
Tiefeneau Hospital Bern Chf: ~30000.-
> Extension of current Nano-Tera study aiming at defining design specifications of implant based on healthy volunteers.
> Main benefit: add clinical component to the project Comprehensive assessment of contraction and compliance Integration of imaging and functional data Establishing normal (healthy subjects vs. patients) Develop new treatment concepts
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DigitalUltrasoundHead[UltrasoundToGo]PascalAlexanderHager
Cable64256coax
ImageSources:Ibmt.fraunhofer.de
healthcare.philips.comwww.akutron.com/products
Digitalhighspeedlink
ProjectScope
Transducerhead BackendSystemAnalogFrontend DigitalProcessing
Conventional2DUltrasoundSystem:
PiezoelectricTransducerArray
FrontendHDIPCB(commercialcomponents)
BackendSystemFPGABoard
(Tablet/Smartphone)
UltrasoundDivisionFraunhofer IBMT
ETHZIIS
DigitalProcessing
Goal: Explorenewdigitalultrasoundhead concept.Collaboration: Buildtwoheads,collaboratorsprovideparts Funding(30k):PCB,Components,IBMTAssistanceTimeTable: 6Month,50%PhDStudentIIS 10%supportpersonnelIIS/IBMT
largestultrasoundresearchunitEuropemorethan20yearsexperience
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Main collaborator: Tommaso Nardi, Laboratory of Composite and Polymer Technology, EPFL Planning work: Work with different polymers and methods for embedding GaAs NWs on equipment of Polymer Lab in EPFLOur part: provide test samples with nanowires, analysis of experiments with SEM, OM and other techniques.Collaborator part: provide new polymer materials, expertise of methods of embedding NWs in polymer, provide equipment for experimentsFunding: 5.000 chf
Flexible PDMS film helps to transfer GaAs nanowire forest from Si substrate to surface of c-Si solar cell
1st Idea: Reliability of NW-polymer composite
Problem with PDMS hardness film with thickness 5 m is very fragileSolution: perform search and analysis of different range of polymers with professional polymer chemist
New polymer material UV curable polyester. High transparence Low viscosity Good adhesion Good hardness
Functional c-Si/GaAs nanowire tandem solar cell
DmitryMikulik,EPFL
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2nd Idea: Reliability of GaAs NW solar cells by analyzing spectral and electrical characteristics
Main collaborator: Mikhail Mintairov, Photovoltaics Lab, Ioffe institute, RussiaPlanning work: Measurements and analysis of results of pilot devices in Photovoltaics lab in Ioffe instituteOur part: provide pilot devices based on GaAs NWs, organize joint workshop/visit to discuss resultsCollaborator part: provide different measurements of solar cells, analysis of measurementsFunding: 10.000 chf
Problem: Reliability of GaAs NW based solar cellsSolution: To realize perspective and weak points of GaAs NW based solar cell - spectral, electric and optical measurements must be performed.
Optical measurements: EQY Initial
measurements Reflectance give
information about surface quality
IQY - depends on structure and p-n junction optical properties
Electro-luminescence pattern determination at different temperatures:Could be applied to evaluate the uniformity of nanowires photo-electrical properties
T= 25C, J=100 mA/cm2 T= -190C, J=5 mA/cm2 T= -190C, J=5.5 mA/cm2
Electrical measurements: IV curves in a wide range of irradiance
allows to obtain a number of important characteristics:
Voc-Jsc dependence to form p-n junction IV curve
resistive losses IV as a difference between p-n junction and practical IV curve
GaAs p-i-n nanowires embedded in flexible PDMS film would play a role of second solar cell, placed on top of conventional c-Si solar cell
ITO
ITO
cSisolarcell
Sunlight
PDMS
Functional c-Si/GaAs nanowire tandem solar cell
DmitryMikulik,EPFL
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LBB Conductive
polymers Implantables
MNSMicro&Nanofabrication
Wearables
APPROACH
AportableEEGsystem (12k) Biocompatibility studies (8k) Clinicalevaluation (10k)
FUNDING
Embeddingconductivenanostructures insoftsubstrates
PARTNERS
Soft&drybiopotentialelectrodes
GOAL
Contact:MoritzThielen,[email protected]
FlurinStauffer MoritzThielen
MOTIVATION
Wearable health monitoring Braincomputerinterfaces Poorperformance of
commercial systemsEnobio from Neuroelectrics
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FacialnerveneuromonitoringisusedtoimprovethesafetyofdrillingintheboneforDCA.
Boneelectricpropertiesrequiredtopredictthedistancebetweendrillbitandnerves.
Budget~30000CHF Costofpersonnel&material Seedprojecttowardssnf proposal
Developmentofanimpedancesetuptostudyelectricandelectrochemicalbonetissueproperties.
Electrochemicaleffects Contacteffects Voltage/frequencydependent Affectedbythetypeofelectrolyte
Bettercharacterizationoftheseeffects CollaborationwithDepartmentofChemistryand
BiochemistryatUniversityofBern&UniversityofBudapest(P.Broeckmann,H.Siegenthaler)
Setupforreliablemeasurementoftheelectrochemicalproperties(optimizestraycapacitance,contactinterface,signal/noiseratio,waveform)
ThomasWyssBalmerISTBUniversityof Berne
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2
Therapeu*c Drug Monitoring (TDM)
Today:
[1] Edurant (Rilpivirine) prescribing informa*on
???
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3
Today:
[1] Edurant (Rilpivirine) prescribing informa*on
0 6 1 2 1 8 2 4 3 0 3 6
1 0
1 0 0
1 0 0 0
T im e a f te r d o s e [H o u rs ]
Rilp
ivir
ine
Co
nc
en
tra
tio
ns
(ng
/m
L)
Target Cmin=44ng/mL
Cmin < 44ng/mL for 40% of popula;on !
TDM of Rilpivirine (an*retroviral drug)
35 000 000 HIV+ 6300 new infec;on/day
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4
Today: Tomorrow:
Therapeu*c Drug Monitoring (TDM)
automated personalized
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5
Population-based percentiles
Individual concentration vs time profile dosing schedule suggestion
Predic*on engine (Bayesian approach) Ergonomic soHware
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6
DBMS, remote data collection
Easy to integrate (Health Level 7 interface)
EzeCHiel light
Clinical interpretation (TDM) Drug developement
Clinical trials
Aggregation of data for the research
Precision Predic;on modeling Time Interoperability Privacy & Security U;lity User-friendly
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7
Team
Dr. Sverine Pe;tprez, Drug models development
Alev;na Dubovitskaya, Data mining, Interoperability
Dr. Manel Aouri, Clinical evalua8on
Prof. T. Buclin, MD Dr. N. Widmer Prof. C. Csajka
A. Chaouch
Dr. M. Guidi
Advisory Board:
Dr. P. Andr
Prof. Y.Thoma
Y. Su]er R. Hooper
Prof. M. Schumacher
Division of Clinical Pharmacology, CHUV Development of drug models, clinical evalua8on
REDS HEIG-VD, HES-SO VS So;ware development, Interoperability
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8
Ac*on Plan
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9
Ac*on Plan
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1/09 Nano-Tera Meeting, Bern| 04 May, 2015
We sell Onsite H2 production system
which is cost effective, cleaner & greener, for fertilizer
and chemical industries
Ready to Launch
Solar Fuel, the smarter way.
SoHHytec
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2/09 Nano-Tera Meeting, Bern| 04 May, 2015
Refineries 20%
Ammonia 53%
Other 20%
Methanol 7%
Our Customer
H2 Usage
Fertilizer and Chemical industries
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3/09 Nano-Tera Meeting, Bern| 04 May, 2015
Problem worth solving:
On site cost effective H2 production using smart combination of concentrated solar energy during day and cheap grid electricity during night using our Integrated PEC device
Lack of cost effective onsite H2 production. 95% of current world H2 production comes from off-site steam reforming of conventional fossil fuels which is
Our Solution:
Not clean & non-renewable
Costly due to specialized transportation
Downscaling the size becomes extremely expensive
Faster degradation of the system
Cleaner & Greener
Highly scalable in size (up/down)
Onsite hence no costly expenses for transportation
Longer and durable life span
Our Opportunity
Lack of cost effective onsite H2
production
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4/09 Nano-Tera Meeting, Bern| 04 May, 2015
Night Operation
Compressor
Storage
Concentrator
H2 O2
H2O
Cheap Grid Electricity
During night
CUSTOMER
PV+ELECTROLYZER
Our Product
Integrate
d PEC
Day Operation
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5/09 Nano-Tera Meeting, Bern| 04 May, 2015
Case Operation Type Price
1 Our System 1.69 $/Kg Great combination of sunlight during day and cheap electricity during night
2 Just electrolysis using electricity (Day + Night)
2.21 $/Kg
Even just day electricity price during the lifespan makes it expensive option
3 Steam reforming requiring transportation
2 $/Kg Transportation alone increase price of hydrogen by 1$/kg* of H2 *Hydrogen Sta.on Compression, Storage, and Dispensing Technical Status and Costs ,G. Parks, R. Boyd, J. Cornish, and R. Remick , NREL Independent Peer Review Report
1 2 3
1.69 $
2.21 $ 2 $
Business Potential
Our H2 Production cost (without CSD) including 15% ROI
1.69 $/Kg
For 50m by 50m system producing 234 Kg H2/ day Exemplary case
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6/09 Nano-Tera Meeting, Bern| 04 May, 2015
How we make Profit
Strategy: 15% ROI plus yearly charges equal to 50% of customers saving potential for next 15 years
day 1 year 1-10 year 10-15
54k $
132k $ 136k $
For the installation of the size of 50m by 50m with 360k $ investment
0
2
1 3 5 7 9 11 13 15 Years
Customers Saving potential Our profits
$/Kg
of H
2
Our system
Distributed steam reforming
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7/09 Nano-Tera Meeting, Bern| 04 May, 2015
Meet our Team
Saurabh Tembhurne CEO and co-founder Doctoral Ass istant in ENERGY Laboratory of Renewable Energy Sc ience and Engineering (LRESE) EPFL, Lausanne
Meng Lin CTO and co-founder Doctoral Ass i s tant in ENERGY Laboratory of Renewable Energy Sc ience and Engineering (LRESE) EPFL, Lausanne
Prof. Sophia Haussener Scientific Advisor Assistant Professor Laboratory of Renewable Energy Sc ience and Engineering (LRESE) EPFL, Lausanne
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8/09 Nano-Tera Meeting, Bern| 04 May, 2015
Gives as Great Opportunity to showcase and demonstrate our product as well as would be a brilliant chance to make new connections and attract tentative investors
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9/09 Nano-Tera Meeting, Bern| 04 May, 2015
THANK YOU
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Wearable sensing devices will represent $47.4B market* in 2019
Wearable electronics should be conformal, light weight and unno6ceable
However current electronic solu@ons are rigid, planar and bulky.
* Source :Onworld Wearable Technologies Consumer Survey
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We are a wannabe EPFL Spin-off - Prof. S. P. Lacour: Laboratory for soM bioelectronics interfaces
Target Market: Electronic companies
We provide B2B technological solu6ons to help industrial partners implement systems that can conform to the human body
Robustness, Cost effec6veness Design flexibility
Patent applica@on ongoing, backed by EPFL TTO
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SolSticE
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SolSticE SolSticE Solar Sticker for Energy
Highest Efficiency MaterialsFlexible
Adhesive
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SolSticE SolSticE Applications
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SolSticE SolSticE Benchmark
Flexibility
Com
fort
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SolSticE SolSticE Planar VS Nanowire
p-doped
n-dopedintrinsic
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10 m
SolSticE SolSticE Achievements
Status
First prototype on Si. Peeling procedure
developed. The Silicon wafer can be
reused. The technique is scalable
independently on the wafer size.
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SolSticE SolSticE Open Challenges
Status
Realization of high conductivity and flexible contacts.
Iterative optimization of the design.
Scale up.
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Princess Astronaut Wizard
SolSticE SolSticE The Team
Jelena Vukajlovic-Plestina
Dmitry Mikulik
Federico Matteini
CTO CEOCOO
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November 24, 2015, MIT Media Lab, Cambridge, MA
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SolSticE SolSticE
nextstepAnsoBrusaHagerMikulik(2x)ThielenWyss1234