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National Capital Area Chapter

Society of Toxicology Newsletter

Electronic Edition

March 2017 Issue No. 41

Gertrude-Emilia Costin, Editor

CHAPTER MISSION STATEMENT 2

MESSAGES FROM THE NCAC-SOT EXECUTIVE BOARD MEMBERS 2

The President, Tracy Chen 2

The Student Liaison, Elena Braithwaite 3

The Graduate Student Representatives, Georgina Harris and Kristin Noell 4

The Post-Doctoral Representative, Shelby Skoog 5

The Website Coordinator, Lorraine Twerdok 6

The Newsletter Editor, Gertrude-Emilia Costin 7

TREASURER’S REPORT, Nancy Beck 8

NCAC-SOT MEMBERSHIP 8

Details 8

Membership Application 9

Current NCAC-SOT members 10

NCAC-SOT EXECUTIVE BOARD MEMBERS CONTACT LIST 14

Election results – Meet the New Board Members 15

NCAC-SOT ACTIVITIES UPDATE 16

Meetings of Interest 16

Workshop: Advances in Causal Understanding for Risk Based Decision Making

(6-7 March 2017) 16

Metabolic Syndrome and Associated Diseases: From Bench to the Clinic

(11 March 2017) 17

Water: Tame or Toxic (11 March 2017) 17

Society of Toxicology Annual Meeting (12-16 March 2017) 18

Letter from the President of SOT 18

NCAC-SOT and Johns Hopkins University Joint Reception/Mixer 19

NCAC-SOT Presenter List at SOT 20

NCAC-SOT Spring Symposium: Safety Assessment of Over-the-Counter 22

Botanicals and Nutraceuticals: Update and Challenges (19 April 2017)

Outreach Activities 24

Update from the Chairs 24

NCAC-SOT Outreach Program Survey 24

WHAT’S NEW IN TOXICOLOGY? Grants for Alternatives Research by Sue Leary 25

MEMBERS ACCOMPLISHMENTS CORNER (September, 2016 through March 2017) 26

Publications and Presentations 26

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CHAPTER MISSION STATEMENT

The National Capital Area Chapter of the Society of Toxicology (NCAC-SOT) was established to provide a

regional focus for scientists of all disciplines interested in toxicology. The Chapter acts to:

Sponsor and co-sponsor symposia on current issues in toxicology

Provide annual awards to an outstanding student and post-doc in toxicology to assist in attending the

annual meeting of the SOT

Maintain communication with the National SOT regarding current toxicology and regulatory concerns

Sponsor Regional Chapter events at the SOT Annual Meetings

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MESSAGES FROM THE NCAC-SOT EXECUTIVE BOARD MEMBERS

President’s Message

Dear NCAC-SOT members,

As you may recall, there have been quite a few changes since our last newsletter issued. I assumed the NCAC-

SOT Presidency due to Erik’s resignation in October, 2016. Our Secretary, Kelly Brant, also resigned in

October due to an inevitable reason. Things happen in life and we understand and appreciate both Erik’s and

Kelly’s service to the NCAC-SOT community. Since this occurred mid-term of their service, the Executive

Board decided to continue functioning with fewer Officers. Although it was about the time for the Board to start

working on details for NCAC and SOT events, we as a team collaborated very well to learn, discuss, and plan

how to better serve our NCAC community. That being said, on behalf of the whole NCAC-SOT community, I

wanted to THANK our Officers (Drs. Nancy Beck, Elena Braithwaite, Gertrude-Emilia Costin, Pedro Del

Valle, Shelby Skoog, Lorraine Twerdok, Ms. Georgina Harris, and Ms. Kristin Noell) for their support and

commitment especially under this special circumstance.

From this newsletter, you will learn about the upcoming activities around the SOT 56th

Annual Meeting held in

Baltimore, just within our region! I hope that many of you will be able to attend the meeting to learn about

toxicology updates, interact with scientists from all over the world, explore potential opportunities, etc. During

the meeting, NCAC-SOT will have a joint reception/mixer with Johns Hopkins University on March 14th

from

6:30 to 9:00 PM at the Pratt Street Ale House. The 2017 NCAC Bern Schwetz Travel Awards will also be

presented during the reception. I hope you are able to join us!

Additionally, I would like to share with you our upcoming NCAC-SOT Spring Symposium, which will be held

on April 19th

at Lister Hill Center auditorium on the NIH main campus, Bethesda. The theme is “Safety

Assessment of Over-the-Counter Botanicals and Nutraceuticals: Update and Challenges”. I wanted to thank Dr.

Jinhui Dou, our NCAC member and an expert in the field, for his great support. During the symposium, we will

also hold a mentoring luncheon, which is led by Dr. Nancy Beck. You will hear more about the symposium in

our future community emails.

Once again, our involvement in Regional Science Fairs (RSFs) has begun. It’s a great opportunity to show our

support in local STEM activities. I wanted to especially thank our NCAC Education and Outreach Committee

(Drs. Pedro Del Valle, Gopala Krishna, and Gladys Erives) for their hard work to coordinate NCAC’s

participation in these meaningful events. Your volunteer service as a RSF judge is much appreciated.

Recently I shared our Officer Election results with you. Let’s congratulate and welcome them to the Board: Dr.

Margaret Whittaker (Vice President/President-Elect), Dr. Xinrong Chen (Secretary), Dr. Charlie Thompson

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(Treasurer), Dr. Laura Savery (Postdoctoral Representative), and Ms. Dana Freeman (Graduate Student Vice

Representative). The new Board term will start on May 1st, 2017. I would also like to take this opportunity to

THANK our Board members who are completing their term for their leadership, dedication and contributions to

NCAC-SOT:

Dr. Nancy Beck served as Treasurer.

Dr. Shelby Skoog served as Postdoctoral Representative.

Ms. Georgina Harris served as Graduate Student Representative.

To build a great community, members are the key. Please don’t forget to renew your membership and spread

the word to your associates to consider joining NCAC! By extending our membership and recruiting new active

members, we will be able to promote more impactful activities in our local Chapter.

Lastly, it’s my goal to keep our community informed with toxicology related news and upcoming events. If you

have topics of interest for future NCAC activities (seminar, webinar, symposium, etc.), please let us know. You

can contact our Board members (here) to share your ideas and comments! We are looking forward to hearing

from you!

Kind regards,

Tracy Chen

NCAC-SOT President

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Student Liaison’s Message

Bern Schwetz is a nationally recognized expert in reproductive and developmental toxicology and has extensive

experience working with industry, academia, and government agencies. Some of his most notable

accomplishments include adjunct professor at the University of Arkansas for Medical Science, member of the

National Academy of Science’s Institute of Medicine, Director of the National Center for Toxicological

Research (NCTR), Acting Director of the Environmental Toxicological Program (National Institutes of Health’s

National Institute of Environmental Health Sciences), and Deputy Commissioner of the Food and Drug

Administration. In Dr. Schwetz’s honor, each year the National Capital Area Chapter (NCAC) of the Society of

Toxicology provides travel awards to help promising early career researchers attend scientific conferences.

Six outstanding applications were submitted for consideration this year. The applications featured important

research in a wide variety of fields and disciplines including risk assessment, biomarker development, and

materials science. Each application was blindly evaluated by five different judges based on the clarity of the

abstract and the quality of the studies performed. Thank you to Nancy Beck, Gertrude-Emilia Costin, Georgina

Harris, Elaine Knight, and Kristin Noell for serving as judges and for their commitment to impartial

adjudication of the award.

Without further ado, the NCAC is delighted to announce the winners of the Bern Schwetz Travel Award.

Congratulations go to:

Bern Schwetz Graduate Student Travel Award

Bernadette Ezeabikwa was awarded first place for her abstract entitled

“Low Grade and High Grade Bladder Cancer Cells Differentially Express

Lewis x Glycan Epitopes”.

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Bern Schwetz Postdoctoral Scholar Travel Award

Peter Petrochenko was awarded first place for his abstract entitled

“Pulsed Laser Deposited Composite PMMA and Nanosilver Thin Film

Device Coating Optimized to Prevent Bacterial Colonization and Support

Bone Stem Cell Growth”.

Teresa Palacios-Hernandez was awarded second place for her abstract entitled

“In vitro Toxicological Evaluation of Ultrasmall Superparamagnetic Iron Oxide

Nanoparticles on Human Coronary Artery Endothelial Cells”.

Laura C. Savery will be recognized with an Honorable Mention Certificate for her abstract

entitled “Deriving a Provisional Tolerable Intake for Intravenous Exposure to Silver

Nanoparticles Released from Medical Devices”.

Ekaterina Mostovenko will be recognized with an Honorable Mention Certificate for her abstract entitled

“Mass Spectrometry Development of Occupational Nanomaterial Exposure”.

Pretal Muldoon will be recognized with an Honorable Mention Certificate for her abstract entitled “Biomarkers

of Behavioral Deficits for Juvenile Environmental Tobacco Smoke Exposure Health Assessment”.

Please join me in congratulating all our winners. Thank you again to all who applied, served as judges and

helped spread the word about the Bern Schwetz travel award. NCAC greatly appreciates all your efforts and

support.

Elena Braithwaite

NCAC-SOT Student Liaison

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Graduate Student Representatives’ Message

To the future of Toxicology, NCAC-SOT Students!!

We hope to meet many of you at the 56th

SOT Annual Meeting and ToxExpo. The Student/Postdoctoral Mixer

is a fun event where you can visit our poster and learn more about the Chapter as well as specialty sections. If

you have not yet signed up for the “Chat with an expert” program, you can still do so if there are spots

available. This offers casual meetups with experienced bench scientists, journal editors, scientific councilors

and executives to name a few. We highly recommend you take advantage of this opportunity.

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Visit http://www.toxicology.org/events/am/AM2017/program.asp#SP for more information on events and

activities for graduate students. If you are looking for networking opportunities, contact any of our officers.

NCAC-SOT invites you to network with professionals from academia, government and industry. As you can

see throughout our newsletter, we are involved in multiple year-round outreach programs and any help is

appreciated.

At the national meeting, the NCAC-SOT will hold a joint reception with Johns Hopkins University. This will be

held 6:30-9 PM on Tuesday, March 14th

. This is your opportunity to meet the different members of this Chapter,

please join us! In addition, we will be hosting an information table March 13th

-15th

in the SOT Pavilion. Help us

increase the number of student members, inform other graduate students of this Chapter so that we can engage

with more scientists in our region.

Baltimore Maryland has a lot of interesting historic and fun things for you to explore, visit

http://baltimore.org/guides-interests for more information.

See you in Baltimore!

Student representative, Georgina Harris (gharri27@jhu.edu)

Vice-student representative, Kristin Noell (kmnoell@umes.edu)

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Postdoctoral Representative’s Message

Dear NCAC SOT Postdoctoral Scholars,

We are looking forward to seeing all of you at the 56th

SOT Annual Meeting and ToxExpo in Baltimore, MD in

a few weeks. The meeting will be a great opportunity for you to share your work and network with other

toxicologists.

I hope you all have registered for the postdoc-specific activities at the meeting, including:

Student/Postdoctoral Scholar Mixer: Sunday, March 12, 7:30 pm to 9:00 pm

o Hilton Baltimore Holiday Ballroom 4 (Ticket required)

In Vitro Toxicology Lecture and Luncheon - Monday, March 13, 11:30 am to 1:00 pm

o Lecture: “Human Organs-on-Chips Testing – Strengths and Challenges” by Anthony Bahinski,

GlaxoSmithKline

o Hilton Baltimore Holiday Ballroom 4 (Ticket required)

Postdoctoral Assembly Luncheon - Tuesday, March 14, 12:00 pm to 1:15 pm

o CC Room 324 (Ticket required)

We also hope to see you at the NCAC and Johns Hopkins University Joint Reception/Mixer at the Pratt Street

Ale House on Tuesday, March 14, from 6:30 pm to 9:00 pm. This will be a fun event to get to know your

colleagues in the area!

Thank you to all of the NCAC postdocs who submitted abstracts for SOT as well as those who applied for the

NCAC Bern Schwartz Travel Award! Congratulations to the Bern Schwartz award winners as well as the

postdocs who received other awards including national SOT, Regional Chapter, Specialty Section, and Special

Interest Group awards. The postdoctoral awardees will be recognized at the PDA Luncheon at the Annual

Meeting.

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Finally, congratulations to the newly elected NCAC-SOT officers! Laura Savery will be the new Postdoctoral

Representative, and we are looking forward to her enthusiasm and leadership on the Board.

For more information and resources for postdoctoral scholars, please feel free to contact me

(Shelby.Skoog@fda.hhs.gov).

Sincerely,

Shelby Skoog

NCAC-SOT Postdoctoral Representative

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Website Coordinator’s Message

Dear NCAC-SOT Members,

The NCAC-SOT leadership team is updating the NCAC-SOT website, which can be accessed from the SOT

website or directly at http://www.toxicology.org/groups/rc/ncac/index.asp. During this process, we are

conducting a major review and update to make the website more useful for our Chapter members as well as

visitors, including potential new Chapter members. While we are conducting updates and revisions, the best

places for you to find up-to-date chapter information are at the following locations:

Announcements of upcoming events, deadlines, and news items; Announcements appear on the right

side of every page of the website

For General Chapter Information see the following web pages which appear on the left side of every

page of the website:

o Home – provides the Chapter mission statement

o Bylaws – provides the nuts and bolts of how our Chapter is organized to conduct business for

our members

o Membership – provides the benefits of being a Chapter member, and forms to join

For Chapter Activity Information see the following web pages which also appear on the left side of

every page of the website:

o Newsletters – provides the most extensive news on Chapter activities; contains links to recent

and archived newsletters back to 2004

o Annual Reports – provides Chapter reports to National SOT Leadership (check out just how

much your Chapter accomplishes each year – you might be surprised!)

o Awards and Opportunities – provides information on current Chapter scholarly and travel

awards, as well as acknowledging our Bern Schwetz Award winners for travel assistance to

recent SOT meetings. Opportunities to participate in community activities are also listed here

The website update process is time-intensive, and requires input from many sources, including our NCAC

Members. Please visit the website and see if there is anything YOU would like to see on the website. This could

be Chapter-related activities, or upcoming activities sponsored by other Chapters or organizations that you think

would be of interest to fellow Chapter members. Please contact me (letwerdok@verizon.net) with website

questions, ideas, or posting suggestions.

Warm Regards,

Lorraine Twerdok

NCAC-SOT Website Coordinator

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Newsletter Editor’s Message

Dear NCAC-SOT Members,

It seems that 2017 is a very fast-paced year, not entirely surprising given that we are in the Chinese Rooster

year. With that in mind, January flew by in no time and by the time of me writing this letter, half of February is

already accounted for. Needless to say, March is around the corner and so is SOT. You have by now read all the

enthusiastic updates from our Executive Board members who look forward to a busy, high quality meeting in

Baltimore. As my fellow Board members, I encourage you to attend the meeting, network, connect and

exchange research ideas at the best venue for the toxicologists to gather and brainstorm.

The direction of my letter is geared towards the concept of team building and communication. I have worked in

multiple and diverse teams over the years, I learned from each experience and carried it to the next scientific or

personal endeavor. During the last part of 2016 and into 2017, I had the opportunity to be part of our Board

team that came together in an extraordinary cohesive way to carry on the mission of the Chapter. As our

President, Tracy Chen, shared, the team found the energy and the generosity to dedicate its time and continue

the ongoing activities after unforeseen circumstances prevented key members of the Board to be available. It is

a rewarding and inspirational experience to be part of such a team and I encourage members of the NCAC-SOT

Chapter to run for elections, become part of the team if elected and encourage others to join the Chapter. It is an

amazing group activity to which you can contribute and learn from. I would like to thank all my fellow board

members for being such a great team and also for helping me tremendously for the preparation of the

newsletters. I look forward to working together with the newly elected members of our Executive Board,

starting with 1 May 2017.

If in Baltimore, visit us at the Chapter’s poster or presentation table and ask us about becoming an active

member of the Chapter or to share your ideas.

Thank you,

Gertrude-Emilia Costin

NCAC-SOT Newsletter Editor

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TREASURER’S REPORT

NCAC-SOT Treasurer's Report – Jan 27, 2017 by

Nancy Beck, Treasurer

Account activity since last report (Winter 2016 Newsletter)

July 31, 2016 (Balance) $10,594.30

Debits

9/9/16 Student Award (Loudon County) $50.00

9/26/16 Student Award (Loudon County) $50.00

Total Debits $100.00

Credits

9/12/16 Dues (Renewals and New Members)

$25.00 10/24/16 $25.00 12/19/16 $645.00 12/19/16 Donation to NCAC $250.00

Total Credits $945.00

Balance $10594.30

December 31, 2016* (Closing balance) *Most recent bank statement in our possession.

$11,439.30

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NCAC-SOT MEMBERSHIP

Details

Did you remember to renew both your SOT and NCAC memberships this year? Annual membership fees for

NCAC-SOT remain unchanged this year and are only $25 for regular memberships and $10 for full-time

students. These negligible fees are used to fund our symposium each year and to support a myriad of student

activities, including student awards, travel supplements, and K-12 outreach.

If you have not yet renewed your regional Chapter membership, please do so today! You can do that online at

http://www.toxicology.org/script/loginredirect2.asp?page=dues, or just fill out and mail in the membership

application form on the next page.

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Membership Application

MEMBERSHIP APPLICATION

Name: ______________________________________________________

Affiliation: ______________________________________________________

Address

______________________________________________________

______________________________________________________

City: __________________________________________

State: _____ Zip Code: ____________

Area Code: ______ Phone: _________________FAX:____________________

E-mail: ______________________________________________________

Membership Type ______ Full Member ($25) ______ Student ($10)

Please check the most appropriate responses:

SOT Member

_____ Yes

_____ No

Highest Degree Attained

_____ A.S. _____ M.P.H.

_____ B.A. _____ M.S.

_____ B.S. _____ M.A.

_____ D.V.M. _____ Ph.D.

_____ D.V.M./Ph.D. _____ Sc.D.

_____ M.D. _____ V.M.D.

_____ M.D./Ph.D. _____ V.M.D./Ph.D.

Type of Affiliation

_____ Academia

_____ Consulting

_____ Contract Lab

_____ Government

_____ Industry- Chemical/Petroleum

_____ Industry- Pharmaceutical

_____ Industry- Other

_____ Other- _____________

Please complete the information above and send with a check, money order or credit card (payable to National Capital Area

Chapter SOT, no POs) to the address below. The NCAC SOT will review your application, and you will be notified within 30

days. Those not accepted will receive a full refund. Current RC members: please do not use this form since your renewal dues are

billed annually through SOT.

Payment Type: Money Order______ Check ______ Credit Card ______

Credit Card # _______________________________________ Exp date ________

Name on Card ______________________________________

Signature

Please send form as a pdf to: If paying by check, please send to:

D. Charles Thompson, Treasurer Society of Toxicology, ATTN: Ashley Black

d.charles.thompson@fda.hhs.gov 1821 Michael Faraday Drive, Suite 300,

Reston, VA 20190

National

Capital Area

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Current NCAC-SOT Members

Dear NCAC-SOT members,

The NCAC-SOT Executive Board considers useful to publish the membership roster in each newsletter. As of March 2017, the Chapter members are

listed below (First NameLast NameInstitution):

Valerie Adams US Army-Public Health Center

Lauren Amable National Institute on Minority Health and

Health Disparities

Jay Ansell Personal Care Products Council

Sarah Attreed Johns Hopkins University

Michael Babich US Consumer Product Safety Commission

Sainath Babu Hampton University

Christopher Bates Exponent Inc

Ilona Bebenek US FDA

Nancy Beck American Chemistry Council

Richard Becker American Chemistry Council

Tracy Behrsing US FDA

Eric Beier US FDA-CTP

Rosonald Bell Indivior

Joseph Betz NIH

Melanie Biggs Consumer Product Safety Commission

Norman Birchfield US EPA-ORD

Adrienne Black 3E Company

Uni Blake American Petroleum Institute

Michael Bolger US FDA

Gary Bond US FDA-CDER

Ivan Boyer Cosmetic Ingredient Review

Steven Bradbury Steven P Bradbury & Associates LLC

Elena Braithwaite US FDA

Kelly Brant US FDA

Chad Brocker National Cancer Institute

Deborah Burgin CDC-ATSDR

Gary Burin Technology Sciences Group Inc

John Burns

Jon Cammack MedImmune Inc

Connie Chen ILSI Health and Environmental Sciences

Institute

Tracy Chen US FDA

Xinrong Chen U S Consumer Product Safety Commission

Weihsueh Chiu Texas A&M University

Makena Clive Johns Hopkins Bloomberg School of Public

Health

Chrissy Cochran US FDA

Joseph Contrera Computational Toxicology Services LLC

Erdem Coskun National Institute of Standards and

Technology

Gertrude-Emilia Costin Institute for In Vitro Sciences

Rodger Curren Institute for In Vitro Sciences

Irina Dahms DSM Nutritional Products Ltd

Pedro Del Valle US FDA-CDER

Marcus Delatte US FDA-CDER

Jose Delgado-Jimenez National Cancer Institute, NIH

Christopher DeMerlis Colorcon Inc

John DeSesso Exponent Inc

Dhanraj Deshmukh University of Maryland Baltimore

Kshama Doshi University of Maryland

Jinhui Dou FDA

Kimberly Ehman WuXi AppTec

Marion Ehrich Virginia-Maryland College of Veterinary

Medicine

Michelle Embry ILSI Health and Environmental Sciences

Institute

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Neeraja Erraguntla American Chemistry Council

Bernadette Ezeabikwa University of Maryland Eastern Shore

Marc Fariss ToxSynergy

Michael Feasel US Army-ECBC

Louan Fisher Toxicology Regulatory Services (TRS)

Suzanne Fitzpatrick US FDA

Jennifer Fleischer ToxServices LLC

Thomas Flynn US FDA-CFSAN

Bruce Fowler

Dana Freeman Johns Hopkins University

Jason Fritz US EPA-NCEA

Shayne Gad Gad Consulting Services

Sanket Gadhia National Center for Advancing

Translational Sciences

Kevin Gaido US FDA

Joan Garey Reproductive Toxicology Center

Chandramallika

(Molly) Ghosh US FDA-CDRH

Peter Goering US FDA

Julia Gohlke Virginia Tech

Emily Golden ToxServices LLC

Gopakumar Gopalakrishnan Supernus Pharmaceuticals Inc

Thomas Gray

Sidney Green

James Griffiths Council for Responsible Nutrition CRN

Rupa Guha University of Maryland Baltimore

Maureen Gwinn US EPA/Office of Research and

Development

Karen Hamernik US EPA

Georgina Harris Center for Alternatives to Animal Testing

Wafa Harrouk US FDA-CDER

Kristina Hatlelid US Consumer Product Safety Commission

Tala Henry US EPA-OPPTS

James Hobson US FDA-CTP

Colette Hodes US EPA-OLEM

Alan Hood US Food & Drug Administration

Eric Hooker US Consumer Product Safety Commission

Keith Hostetler Toxicology Regulatory Services (TRS)

Terry Hrubec Via College of Osteopathic Medicine

Virginia Campus

Chia-Wen Hsu US FDA

Annette Iannucci Occupational Safety and Health

Administration

Jon Inglefield Emergent BioSolutions Inc

William Irwin Regulatory

Nikolai Ivanov Philip Morris International

David Jackson US Army Center for Environmental Health

Research

David Jacobson Kram ToxRox Consultancy, LLC

Devaraya Jagannath Toxicology Consulting Services

Samantha Jones US EPA-NCEA

Bernard Jortner Virginia-Maryland College of Veterinary

Medicine, Virginia Tech

Athena Keene Afton Chemical Corporation

Raju Khatri University of Maryland Baltimore

Do Hyung Kim Henry M. Jackson Foundation

James Kim EOP Office of Management and Budget

Elaine Knight NIH-NCI

Charles Kokoski US FDA

Andrew Kraft US EPA-NCEA

Gopala Krishna Supernus Pharmaceuticals Inc

Francis Kruszewski American Cleaning Institute

James Lamb Exponent Inc

Cindy Landgren Defense Threat Reduction Agency

Amy Lavin Williams Exponent Inc

Jonathan Leshin United States Public Health Service

Nastassja Lewinski Virginia Commonwealth University

Cissy Li US FDA-CFSAN

Anne Loccisano Exponent Inc

Linda Loretz Personal Care Products Council

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James MacGregor Toxicology Consulting Services

Judith MacGregor Toxicology Consulting Services

Michael Madejczyk US Army CEHR

Susan Makris US EPA-ORD

Wimolnut Manheng US FDA-CDER

Nikki Maples-

Reynolds Waterborne Environmental Inc.

Suzanne Martos Johns Hopkins University

Joanna Matheson US Consumer Product Safety Commission

Kathleen McCoy Virginia Commonwealth University

Timothy McGovern US FDA

Marie McKeon MilliporeSigma (BioReliance/EMD

Millipore)

William Mendez ICF International

Donna Mendrick US FDA-NCTR

Beth Mileson Technology Sciences Group Inc

Michael Morrow JPEO Medical Countermeasure Systems

Janet Moser Dept of Homeland Security

Ekaterina Mostovenko Virginia Commonwealth University

Frederic Moulin US FDA

Pretal Muldoon Virginia Commonwealth University

Jorge Muñiz Ortiz US Environmental Protection Agency

Caitlin Murphy Smithers Avanza

Laine Myers US FDA

Alexander Nguyen North Carolina State University

Simone Nicholson MedImmune Inc

Andrey Nikiforov Toxicology Regulatory Services (TRS)

Kristin Noell University of Maryland Eastern Shore

Ofelia Olivero NIH-NCI

Robert Osterberg Osterberg Pharm-Tox Consulting

Andrew Ottens Virginia Commonwealth University

Teresa Palacios-

Hernandez US Food and Drug Administration

Geoffrey Patton US FDA

Leslie Patton Technology Sciences Group Inc

Peter Petrochenko US FDA

Jennifer Pierson ILSI Health and Environmental Sciences

Institute

Anne Pilaro US FDA-CBER

Caroline Pinto US EPA-ORISE

Karen Porter PointCross Life Sciences

Resha Putzrath Navy and Marine Corps Public Health

Center

Kathleen Raffaele US EPA-OSWER

Jennifer Rayner SRC

Gunda Reddy Army Public Health Center

Emily Reinke US Army Public Health Center

Sharon Reutter-Christy Edgewood Chemical Biological Center

Paul Roney BARDA

Leah Rosenfeld US FDA

Laurie Roszell Army Public Health Center

Shakil Saghir Smithers

Laura Savery US FDA

Louis Scarano US EPA

Anthony Scialli Scialli Consulting LLC

Pankaj Sethi University of Georgia

Jennifer Shing FDA

Shelby Skoog US FDA

Deborah Smegal US FDA

Martin Stephens Johns Hopkins Bloomberg School of Public

Health

Stephan Stern Cancer Research Technology Program

Leidos Biomedical Research Inc

Dale Strother ToxSolve LLC

Evi Struble US FDA

Richard Thomas Intercet Ltd

D Charles Thompson US FDA-CDER

Scott Thurmond US FDA-CFSAN

Richard Troast Troast Environmental Consulting

Lorraine Twerdok TWERDOK CONSULTING, LLC

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Vipin Tyagi University College of Medical Sciences and

GTB Hospital (University of Delhi)

René Viñas Grocery Manufacturers Association

Zhengxi Wei University of Rhode Island

Kimberly White

Margaret Whittaker ToxServices LLC

Paddy Wiesenfeld US FDA-CFSAN

Jessica Wignall ICF International

Gary Wolfe Gary Wolfe Toxicology LLC

Linnzi Wright US Army Edgewood Chemical Biological

Center

James Yager Johns Hopkins Bloomberg School of Public

Health

Tracey Zoetis SciLucent LLC

Joanne Zurlo Johns Hopkins Bloomberg School of Public

Health

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NCAC-SOT EXECUTIVE BOARD MEMBERS CONTACT LIST

President: Tracy Chen (2017-2018)

U.S. Food and Drug Administration

301-796-3597

Tracy.Chen@fda.hhs.gov

Past President: Pedro L. Del Valle (2017-2018)

U.S. Food and Drug Administration

301-796-2111

pedro.delvalle@fda.hhs.gov

Treasurer: Nancy Beck (2014-2017)

American Chemistry Council

202-249-6417

Nancy_Beck@americanchemistry.com

Secretary: Open until May 1st, 2017

Councilors: Gertrude-Emilia Costin (2015-2018)

Newsletter Editor

Institute for In Vitro Sciences, Inc.

301-947-6524

ecostin@iivs.org

Lorraine Twerdok (2016-2019)

Website Coordinator

TWERDOK CONSULTING, LLC

letwerdok@verizon.net

Elena Braithwaite (2016-2019)

Student Liaison

U.S. Food and Drug Administration

240-402-4540

Elena.Braithwaite@fda.hhs.gov

Postdoctoral Shelby Skoog (2015-2017)

Representative: U.S. Food and Drug Administration

301-796-2800

Shelby.Skoog@fda.hhs.gov

Graduate Georgina Harris (2015-2017)

Student John Hopkins University

Representative: 410-614-4916

gharri27@jhu.edu

Graduate Kristin Moneque Noell (2016-2017)

Student University of Maryland Eastern

Vice- Shore

Representative: Kmnoell@umes.edu

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Election Results – Meet the New Board Members New elected Board Members will join the Board on May 1

st, 2017.

Dr. Margaret Whittaker – Vice President/President-Elect

Dr. Xinrong Chen – Secretary

Dr. Charlie Thompson – Treasurer

Dr. Whittaker is the Managing Director and Chief Toxicologist of ToxServices LLC. She

manages ToxServices projects for the United States EPA’s Safer Choice Program, Clean

Production Action’s GreenScreen for Safer Chemicals, and Cradle to Cradle Certified

Program. As project manager and technical lead, Dr. Whittaker has contributed to and/or

managed the development of hundreds of human health risk assessments, chemical hazard

assessments, exposure assessments, as well as hundreds of product-specific toxicology

evaluations. Dr. Whittaker is one of the pioneers in the field of chemicals alternatives

assessments and drinking water risk assessment methods, and is a key contributor to

advancing these methods around the world. Dr. Whittaker is a Diplomate of the American

Board of Toxicology who earned a Ph.D. in Toxicology from The University of Maryland,

Baltimore and an M.P.H. in Environmental Health from The University of Michigan. Dr.

Whittaker is a U.K./EuroTox Registered Toxicologist, as well as a Chartered Biologist and

Fellow of the U.K. Royal Society of Biology.

American board-certified toxicologist (DABT) with over 7 years’ experience in toxicological

evaluation and risk assessment for products regulated by the Food and Drug Administration

(FDA), Environmental Protection Agency (EPA), and the Consumer Product Safety

Commission (CPSC). Currently works as a regulatory toxicologist at CPSC and is actively

involved in several working groups sponsored by ICCVAM, ISO, and ASTM. Functions as

an agency coordinator for CPSC and EPA quarterly chemical hazard meeting. Years of

experience in drug metabolism, genetic toxicology, reproductive and developmental

toxicology, liver toxicology, in vitro alternative assay, and regulatory toxicology; capable of

presenting and explaining scientific concepts in an easy to understand way; strong at problem

solving, communication, leadership and decision making; active member of Society of

Toxicological (SOT), Society of Risk Assessment (SRA), and Society of Teratology for

many years.

Donald Charles (Charlie) Thompson earned a B.S. in Pharmacy and a Ph.D. in Toxicology

from the University of North Carolina at Chapel Hill. He is a diplomate of the American

Board of Toxicology (D.A.B.T.). Prior to undertaking his doctoral work, he practiced

pharmacy for a brief stent in the retail, hospital, and pharmaceutical industry sectors. His

doctoral research at UNC was conducted under the tutelage of Dr. Steve Chaney (Department

of Biochemistry and Biophysics, School of Medicine and Curriculum in Toxicology),

investigating the biochemical toxicology of platinum-based anti-neoplastic agents. Since

earning the doctorate, he has worked at Procter & Gamble (Human & Environmental Safety,

Laundry & Cleaning Products) in Cincinnati, OH, USFDA/Center for Food Safety and

Applied Nutrition/Office of Food Additive Safety, Burdock Group Consultants (food,

beverage, dietary supplements, pet food, animal feed, and cosmetics), USEPA/Office of

Research and Development/Integrated Risk Information System Program, and most recently,

USFDA/Center for Drug Evaluation and Research/Office of New Drugs. His current

responsibilities include pharmacology/toxicology oversight of the nonprescription (OTC)

drug products. In addition to his work, Charlie is currently serving as President of the

Association of Government Toxicologists (AGT).

16

Dr. Laura Savery – Postdoctoral Representative

Ms. Dana Freeman – Graduate Student Vice Representative

- // -

NCAC-SOT ACTIVITIES UPDATE

Meetings of Interest

Workshop: Advances in Causal Understanding for Risk Based Decision Making

Workshop Date: March 6-7, 2017

Workshop location: Washington, D.C., and via webcast

Workshop Description: New molecular and informatics approaches have advanced understanding of how molecular pathways are

affected by exposure and the molecular networks involved in disease. However, these advances are often not yet

deemed sufficient to establish causality for public health risk assessments; regulators still rely primarily on

traditional apical endpoints, such as those endpoints observed in animal studies.

Join a workshop on March 6-7, 2017, hosted by the Standing Committee on Emerging Science for

Environmental Health Decisions, to discuss the current thinking surrounding causal models, how novel

approaches and tools are relevant for environmental health, and how they can be incorporated into the decision

making process.

Held in Washington, DC and webcast, this free, 2-day workshop will bring together leading environmental

health experts, toxicologists, statisticians, sociologists, epidemiologists, regulators and experts from other fields

that utilize different data streams for establishing causality in complex systems. Please register today!

Please visit the workshop website to register to attend and for more information, including the preliminary

agenda: http://nas-sites.org/emergingscience/.

Dr. Savery is an ORISE postdoctoral fellow at the FDA in the Center for Devices and

Radiological Health, where she is currently developing a safety assessment approach for the

release of silver nanomaterials associated with medical devices. She received her doctorate in

Biochemistry and Molecular Biology from the University of Maine in 2013. She has been

awarded funding including an ORISE postdoctoral fellowship, USEPA STAR Fellowship

(graduate), SMART program internship at Baylor College of Medicine (undergraduate) and a

Coastal Bend Health Education Center Research Grant (undergraduate). She has authored six

peer-reviewed publications and thirty poster or oral presentations at national and international

conferences. She has been a member of the SOT since 2005 and has served the SOT in the

following capacities: Student Representative of the Metals Specialty Section (2012-2014) and

the Northeast Regional Chapter (2006-2007).

Dana Freeman is a predoctoral student in Toxicology at the Johns Hopkins Bloomberg

School of Public Health. She moved to Baltimore, MD from Atlanta, GA where she received

her bachelor’s degree in Biochemistry at the Georgia Institute of Technology. She became

interested in a career in toxicology during her ORISE fellowship at the US Centers for

Disease Control. She is pursuing research that explores mechanisms behind gene-

environment interactions in the brain. She recently joined the laboratory of Dr. Zhibin Wang

to study human environmental epigenomes. She is active in the Environmental Health &

Engineering student organization (EHESO) and serves as the student representative in her

department’s research retreat planning committee. She is a new member of SOT and

interested to become more involved in the organization and in the promotion of toxicological

research across the National Capital Area.

17

Metabolic Syndrome and Associated Diseases: From Bench to Clinic

Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic, an SOT 56th

Annual Meeting

Satellite, will address a major public health concern. The overarching objectives of this conference include

defining knowledge gaps, identifying research needs, protecting public health, and empowering product

development.

Location: Baltimore, Maryland, immediately before SOT 56th

Annual Meeting

Date: Saturday, March 11, 2017

What knowledge will you gain:

Greater understanding of developmental aspects and challenges in therapeutic strategies for associated

diseases;

Enhanced appreciation for the mechanisms (e.g., microbiome, inflammation, mitochondrial dysfunction)

that underlie these pathologies as well as the effects of drugs and environmental agents;

Increased awareness of the pathways and risk factors leading to disease and how these pathways can be

perturbed to develop drugs for disease interventions; creating a unique combination likely to lead to new

thought processes; and

Additional opportunities for scientific collaborations.

To register and submit an abstract so you can participate in our extended poster session, visit the conference

website. This conference is organized under the auspices of the SOT Contemporary Concepts in Toxicology

(CCT) Conferences Committee.

- // -

Water: Tame or Toxic?

Time: 2-4 PM, 3/11/2017, Saturday

Location: Institute of Marine and Environmental Technology (IMET), 701 E Pratt Street, Baltimore, Maryland

21202

Event Website: http://imet.usmd.edu/water

Description: Water is a precious resource. We drink it, bathe in it, play in it, and are over 50% composed of it. It is necessary

for life as we know it. As harmless and as welcome as it can be, in certain circumstances water and the aquatic

environment can pose a threat to our health. As the Society of Toxicology prepares to meet in Baltimore for its

annual conference beginning March 12, please join the Toxicology Education Foundation and the Institute of

Marine and Environmental Technology for this free program to learn more about the safety and hazards of

water. Presentations will cover principles of toxicology, water pollution, drinking water contamination, toxic and

poisonous marine organisms, water overdose, seafood contamination, and more.

Agenda: Introduction and Overview – Philip Wexler, National Library of Medicine (10 minutes)

Welcome to IMET – Russell Hill, Institute of Marine and Environmental Technology (10 minutes)

The Hitchhiker’s Guide to Toxicology (What Makes a Poison?) – Toni Hayes, Alynylam

Pharmaceuticals (20 minutes)

Food Poisoning, Seriously – Potentially Dangerous Seafood-related Poisoning – Hong Kim,

Maryland Poison Center (20 minutes)

All the Thinking About What You’re Drinking – Virunya Bhat, NSF International (20 minutes)

Is the Green Water Safe? And can it be made Clear? – Al Place, Institute of Marine and

Environmental Technology (20 minutes)

DNA markers can help pinpoint sources of sewage in Baltimore’s harbor – Eric Schott, Institute of

Marine and Environmental Technology (20 minutes)

18

Annual Society of Toxicology Meeting

Dear Colleagues,

On behalf of SOT Council, the SOT Committees, Regional Chapters, Special Interest Groups, Specialty

Sections, SOT Supporters, exhibitors, and other partners, I invite you to join us in Baltimore, Maryland, March

12–16, 2017, for the SOT 56th

Annual Meeting and ToxExpo.

Approximately 6,500 toxicologists from more than 50 countries are expected to share their research and

expertise during the 160+ Scientific Sessions, featuring nearly 2,500 abstracts. This makes the SOT Annual

Meeting an ideal place to expand your scientific knowledge, find new collaborators, and catch up on the latest

techniques and initiatives.

Every year, networking is a key component of the meeting – from the Welcome Reception to Regional Chapter,

Specialty Interest Group, and Specialty Section Receptions and all of the events in between. At this year’s

meeting, plan to visit ToxExpo from 12:30 pm to 1:20 pm on Tuesday, March 14, for dedicated networking time,

as only a limited number of Scientific Sessions are programmed during this time.

More than 350 exhibitors are expected in this year’s ToxExpo, where you can discover new products and

technology, career and partnership opportunities, and more. ToxExpo is open Monday to Wednesday from 9:15

am to 4:30 pm, and I encourage all attendees to schedule time to visit our exhibitors.

SOT is pleased to be returning to Baltimore, the location of the 2009 Annual Meeting and ToxExpo. The

Convention Center is located in downtown Baltimore, adjacent to the beautiful Inner Harbor and the historic

Little Italy neighborhood. A short walk from the center is the National Aquarium, Port Discovery, the B&O

Railroad Museum, and other attractions. And don’t forget the award-winning restaurants, where you can sample

the famous Chesapeake Bay blue crabs.

I hope you join us in Baltimore for the 56th

Annual Meeting and ToxExpo to help SOT fulfill its mission of

creating a safer and healthier world by advancing the science and increasing the impact of toxicology.

Sincerely,

John B. Morris, PhD

2016–2017 SOT President

19

20

Annual SOT NCAC-SOT Presenter List (presented by day/date, time, alphabetical order – author’s last name)

Date Time Session Title Abstract ID/

Poster Board

Author(s)

Presentation Title Institution First (initial). Last

Name

3/13/2017 11:45 AM to

12:15 PM

Regional Chapter, Special Interest

Group, and Specialty Section Poster

Sessions - Representative Attended

NCAC-SOT

Poster

NCAC-SOT

Representatives

Creating local networks between toxicologists in

Maryland, Virginia, and the District of

Columbia

NCAC-SOT

3/13/2017 2:00 PM to

4:45 PM

Workshop Session: Bispecific

Molecules: Nonclinical and Clinical

Development Challenges

1562

(2:00 PM) P. Del Valle

Chairperson

Historical Perspectives of Bispecific

Antibodies

US FDA –

CDER

3/14/2017 9:30 AM to

12:45 PM

Neurotoxicology: General

Neurotoxicity 1748/P233 G. Harris

Toxicity and Resilience Mechanisms in Luhmes

3D Model Exposed to Rotenone

Johns Hopkins

University,

Bloomberg

School of

Public Health

3/14/2017 9:30 AM to

12:45 PM

Exposure Assessment and

Biomonitoring 1911/P535 E. Mostovenko

Mass Spectrometry Development of

Occupational Nanomaterial Exposure

Biomarkers

Virginia

Commonwealth

University

3/14/2017 9:30 AM to

12:45 PM Tobacco Products 1928/P554 P. Muldoon

Biomarkers of Behavioral Deficits for Juvenile

Environmental Tobacco Smoke Exposure Health

Assessment

Virginia

Commonwealth

University

3/14/2017 1:15 to 4:30

PM Metals III 2129/P347 L. Amable

Single Cell Cisplatin and Other Metal

Measurements by ICP-MS NIMHD/NIH

3/14/2017 1:15 to 4:30

PM Genetic Toxicity 2278/P636 G.E. Costin

The 3D Human Reconstructed Skin

Micronucleus Assay (RSMN) Using the

Epiderm™ Tissue: Validation and Application

to the Safety Assessment of Cosmetics

Ingredients

IIVS

3/14/2017 1:15 to 4:30

PM Biomarkers 2030/P136 B. Ezeabikwa

Low Grade and High Grade Bladder Cancer

Cells Differentially Express Lewis X Glycan

Epitope

University of

Maryland

Eastern Shore

3/14/2017 1:15 to 4:30

PM Medical Devices 2140/P404 P. Petrochenko

Pulsed Laser Deposited Composite PMMA and

Nanosilver Thin Film Device Coating

Optimized to Prevent Bacterial Colonization and

Support Bone Stem Cell Growth

US FDA

3/14/2017 1:15 to 4:30

PM Metals III 2130/P348

E. Shide

L. Amable

Characterization of the Ovarian Cancer Whole

Cell and Mito-Metallome NIMHD/NIH

3/15/2017 9:30 AM to

12:15 PM

Workshop Session: Challenges and

Novel Approaches

Evaluating Developmental and

Reproductive Toxicity of

Biotherapeutics

2359

(11:30 AM) P. Del Valle

Thinking Beyond DART Studies for Risk

Assessment of Biotherapeutics

US FDA –

CDER

21

Date Time Session Title Abstract ID/

Poster Board

Author(s)

Presentation Title Institution First (initial). Last

Name

3/15/2017 12:30 PM to

1:50 PM

Informational Session:

Communicating Toxicology

to the Public

2730

(12:48 PM) N. Beck Communicating Information on Chemical Safety

American

Chemistry

Council

3/15/2017 1:15 to 4:30

PM

Alternatives to Mammalian Models I:

Liver, Ocular, and Skin Alternatives 2745/P113 G.E. Costin

Addressing the Assignment of US EPA Hazard

Categories for Dermal Safety by a Revised

Prediction Model of the Validated In Vitro Skin

Irritation Test (OECD TG 439)

IIVS

3/15/2017 1:15 to 4:30

PM Nanotoxicology: General 2902/P364 L. Savery

Deriving a Provisional Tolerable Intake for

Intravenous Exposure to Silver Nanoparticles

Released from Medical Devices

US FDA

3/16/2017 8:30 AM to

11:45 AM Late-Breaking Poster Session 6 3561/P536 G. Krishna

Genotoxicity Assessment of Viloxazine (spn-

812), a Norepinephrine Reuptake Inhibitor, as a

Novel Treatment for Attention Deficit

Hyperactivity Disorder

Supernus

3/16/2017 8:30 AM to

11:45 AM Late-Breaking Poster Session 6 3281/P250 G. Krishna

Comparative Repeat Dose Toxicity Studies in

Adult and Juvenile Rats for Viloxazine (spn-

812), a Norepinephrine Reuptake Inhibitor,

Investigated as a Novel Treatment for Attention

Deficit Hyperactivity Disorder

Supernus

3/16/2017 8:30 AM to

11:45 AM Late-Breaking Poster Session 3 3372/P343 Kristin Noell

Parasites as an Alternative Model for Lipid

Metabolism: Gene Expression Analysis of an

Oyster Parasite Perkinsus marinus during Lipid

Starvation

University of

Maryland

Eastern Shore

22

NCAC-SOT 2017 Spring Symposium: Safety Assessment of Over-the-Counter Botanicals and

Nutraceuticals: Update and Challenges

Safety Assessment of Over-The-Counter Botanicals and Nutraceuticals:

Update and Challenges

Time: 4/19/2017, Wednesday, 8:30 AM-4:10 PM

Location: Lister Hill Center Auditorium, National Institutes of Health, Bethesda, Maryland

Registration link: In person registration: https://www.surveymonkey.com/r/X2FXJTQ

Webcast registration: https://aim-hq.webex.com/aim-

hq/onstage/g.php?MTID=eae77ba5054c30c3f2819202c5a5101d9

There is no fee to attend the event but registration is required by 5 PM, Monday, April 17.

Synopsis:

Like drugs, the efficacy and safety of over-the-counter (OTC) botanicals and nutraceuticals are important to the

public health. Their broader accessibility to the public makes the above concerns more prominent. Due to their

complexity in nature, the analysis and evaluation of these products are challenging. The goal of the symposium

is to provide an update and overview of these challenges from different perspectives.

Lunch: Cafeteria is on the floor below LHC auditorium. Attendees can easily go downstairs and have lunch

there.

TENTATIVE AGENDA

Please see the draft agenda on the next page.

During our symposium, we will hold a mentoring luncheon from 11:30 AM to 12:30 PM. This event is an

opportunity for our members to learn more about careers in academia, government, and industry in an informal

setting. Participants to the mentoring luncheon will receive boxed lunches free of charge. Pre-registration by

March 27 (using the above link) is required for your participation. Interested mentors and mentees: please

contact Dr. Nancy Beck at Nancy_Beck@americanchemistry.com if you have questions or require further

information.

We would also like to invite our NCAC members, undergraduate students, graduate students, and

postdoctoral researchers to join our Poster Session (12:30-1:30 PM) by submitting and sharing your research

projects with our community. Pre-registration by March 27 (using the above link) is required for your

participation. Once your registration is complete, please contact Dr. Elena Braithwaite at

doctorelena@yahoo.com to provide your poster abstract and acquire additional information.

Participating undergraduate students and graduate students: please keep your receipts/records and contact

Dr. Nancy Beck at Nancy_Beck@americanchemistry.com for travel reimbursements post event.

23

Tentative Agenda:

Time Topic Speaker

8:30-9:00 AM Registration opens

9:00-9:05 AM Introductory welcome comments, logistics Tracy Chen, Symposium Chair

(NCAC-SOT President)

9:05-9:45 AM

Botanical identity, uses, and safety translated

to new dietary ingredient notification (NDIN)

information

Steven Casper, Center for Food

Safety and Applied Nutrition

(CFSAN), U.S. Food and Drug

Administration (FDA)

9:45-10:30 AM

Applying toxicology and other data to

support clinical development of botanical

drugs

Jinhui Dou, Center for Drug

Evaluation and Research (CDER),

FDA

10:30-10:45 AM Break

10:45-11:30 AM

USP botanical quality standards:

contributions in quality control & safe use of

botanicals

Hellen Oketch, United States

Pharmacopeia (USP)

11:30 AM -1:30 PM

Lunch: Cafeteria is on the floor below LHC

auditorium.

Mentoring Luncheon: 11:30 AM-12:30 PM

Poster Session: 12:30-1:30 PM

General audience: Lunch on your

own.

Participants in the mentoring

luncheon will meet at the lobby area

to receive boxed lunches and to join

the activity. Please contact Dr. Nancy

Beck for details.

1:30-2:10 PM Advising cancer patients regarding risks and

benefits of botanicals and nutraceuticals

Jeff D. White, National Cancer

Institute (NCI)

2:10-2:50 PM Analytical developments for identification

and authentication of botanicals

James Harnly, United States

Department of Agriculture (USDA)

2:50-3:30 PM National Institutes of Health support of

dietary supplement research

Barbara Sorkin, Adam Kuszak,

Office of Dietary Supplements

(ODS), National Institutes of Health

(NIH)

3:30-4:00 PM Panel discussions Moderator: Jinhui Dou

4:00-4:10 PM Wrap-up Tracy Chen (NCAC-SOT President)

Interested in joining NCAC-SOT? Please browse our website (homepage and membership) for additional

information or contact our board members (list here) if you have questions.

24

Outreach Activities

Update from the Chairs

Dear NCAC-SOT members,

The Education and Outreach Committee is coordinating efforts for judging at 8 Regional Science Fairs (RSF)

around the Capital area. We will judge toxicology-related projects and present the NCAC-SOT Toxicology

Award consisting of a Certificate and a first prize for $100 and a Certificate and second prize for $50. Funding

for this activity was kindly provided by SRC, a not-for-profit research and development company in the Capital

Area.

The Committee would like to invite NCAC members to volunteer and participate in these efforts. NCAC

volunteers are expected to be at the RSF usually at 8:00 am, have breakfast and organize among themselves for

the judging session. RSF usually ends by 2:00 pm. Volunteers are asked to take pictures of the judging team and

during presentation of awards.

If you would like to volunteer, please send an email to Pedro.DelValle@fda.hhs.gov indicating your choice of 1

or more RSF. It is a great opportunity for interaction with youth minds and a rewarding exercise being able to

touch lives of future scientists. You will be amazed at the new ideas, deep understanding of science and

thoughts of many High School students presenting at these RSF. Looking forward to receiving your choice(s).

Regional Science Fairs Sat. March 4 Anne Arundel County at North County High School, Glen Burnie, MD

Sat. March 11 DC STEM Fair at Dunbar High School, Washington, DC

Sat. March 11 Prince William County at Kelly Leadership Center, Manassas, VA

Sat. March 18 Prince Georges County at Charles Herbert Flowers High School, Springdale, MD

Sat. March 18 Fairfax County at Robinson (High) Secondary School, Fairfax, VA

Sat. March 18 Science Montgomery at FDA White Oak Campus, Silver Spring, MD

Thu. March 23 Loudoun County at Riverside High School, Leesburg, VA

Sat. March 25-26 Baltimore Science Fair at Towson University, Townson, MD

THANK YOU FOR VOLUNTEERING

Gladys Erives

Gopala Krishna

Pedro L. Del Valle

- // -

NCAC-SOT Outreach Program Survey

Dear NCAC members,

In an effort to promote the field of toxicology to students, the members of the Executive Board of the National

Capital Area Chapter of the Society of Toxicology (NCAC-SOT) would like to learn from the NCAC members

about their interest and availability to participate in various activities outlined in the survey that can be accessed

at the following link: https://www.surveymonkey.com/r/LYFT2BC. The activities included in the survey have

been suggested by our colleague and fellow member of NCAC-SOT, Dr. Deepa Rao.

We appreciate you taking the time to fill out this brief survey. Please complete the survey by 31 March 2017.

Thank you for your time and input and we look forward to your participation in these proposed educational and

outreach activities.

NCAC-SOT Executive Board

25

WHAT’S NEW IN TOXICOLOGY?

In this Spring issue of the NCAC-SOT Newsletter, we invited the President of Alternatives Research and

Development Foundation (ARDF), Ms. Sue Leary, to share with us her perspective on the contribution of

research grants supporting the field of in vitro toxicology. As the current ARDF Grant Review Coordinator, I

greatly enjoy the collaboration with ARDF and wanted to connect through the means of our Newsletter the

NCAC-SOT community with the strong supporter of alternative methods to animal testing that ARDF is.

Grants for Alternatives Research

By Sue Leary

In 1993, the first ‘World Congress on Alternatives and Animal Use in the Life Sciences’ was held in

Baltimore - organized by Professor of Toxicology Alan Goldberg, Founding Director of the Center for

Alternatives to Animal Testing at Johns Hopkins University. It signaled the establishment of an international

network of in vitro scientists and science policy-minded advocates for animals. They recognized that serious

work to advance alternatives and the 3Rs would require expansion of an intellectual community drawn from

academia, industry, government and NGOs. That same year, the Alternatives Research & Development

Foundation (ARDF) was incorporated in order to focus on funding development of alternative methods.

Among our first projects was a series of grants to develop alternative methods of producing, on a small

to medium scale, monoclonal antibodies without ascites in mice. Commercial bioreactors could serve larger

scale production, but bench scientists apparently considered in vitro production a barrier. A series of

collaborative grants were awarded and a system using a gas-permeable bag and other readily available lab

equipment ultimately provided an alternative to animal use that was cost-effective and practical, with basic in

vitro skills.

A clear goal was identified and target achieved, which is a dream of most funders. But in spite of this

early success, ARDF became aware that many areas had potential for utilizing alternative methods - particularly

toxicology where long-established test methods seemed to be ready for a ‘refresh.’

And so ARDF’s annual ‘Alternatives Research Grant Program’ became known as an open call for

proposals addressing any area in research, testing or education with a potential for replacing or reducing animal

use. After a decade, in 2003, an important change occurred: ARDF enlisted the expertise of the Institute for In

Vitro Sciences (IIVS) and principals Drs. Rodger Curren and John Harbell. This collaboration continues today

with IIVS coordinating the scientific review of all proposals received. Over the years, IIVS and ARDF have

engaged experts in the a number of fields who have kindly agreed to review grant proposals.

Another milestone was after the publication in 2007 of the National Academy of Sciences Report,

‘Toxicity in the 21st Century: A Vision and a Strategy’. That prompted ARDF to encourage submissions of

proposals that addressed the approaches articulated in the report. Technological developments and growing

interest regarding in vitro and in silico methods have combined to bring very thoughtful and innovative

scientists to ARDF seeking support.

Today, ARDF attracts a select group of applicants who are involved in developing non-animal disease

models, models for educational demonstrations, and models for toxicity testing. Grants in 2016 were awarded to

projects that included ‘cervix-on-a-chip’ and a blood brain tumor barrier study, reflecting the modern days of in

vitro toxicology.

Funding goes mostly to U.S. universities, although the requirement is only that applicants be associated

with “non-profit, tax-exempt, educational and/or research institutions, or a foreign equivalent.”

ARDF has definitely contributed to the needed expansion of the intellectual community around

alternatives. For example, in 1999 and 2000, grants were awarded to the lab of Dr. Damir Janigro, at Cleveland

Clinic. Dr. Luca Cucullo, one of his post-docs at the time, went on to establish his own lab at Texas Tech

Health Sciences University, and now receives grant support for his lab. Those are the rewards of running a grant

program: the people who bring their best resources to the problem and embrace the work as a career.

ARDF’s current grant application deadline is May 1, 2017. Information and application materials are

available at: www.ardf-online.org.

26

MEMBERS ACCOMPLISHMENTS CORNER (September, 2016 through March 2017)

At NCAC-SOT we like to acknowledge the accomplishments of our members. The Newsletter Editor will

send an email to the members asking to share their publications, presentations and other accomplishments from

the last number of the newsletter to date to be included in the next number. We are happy to spread the word of

your successes, so please take advantage of this opportunity to share them with your colleagues.

Publications and Presentations

Presented in alphabetical order based on the author who is member of the NCAC-SOT (underlined)

Manuscripts

Birlea S.A., Costin G.E., Roop D.R., Norris D.A. Trends in Regenerative Medicine: Repigmentation in Vitiligo

Through Melanocyte Stem Cell Mobilization. Med. Res. Rev. 2016 Dec 28. Doi: 10.1002/med.21426 (Epub

ahead of print).

Walters R.M., Gandolfi L., Mack M.C., Fevola M., Martin K., Hamilton M.T., Hilberer A., Barnes N., Wilt N.,

Nash J.R., Raabe H.A., Costin G.E. In Vitro Assessment of Skin Irritation Potential of Surfactant-Based

Formulations Using a 3-D Skin Reconstructed Tissue Model and Cytokine Response. Altern Lab Anim.

2016, 44: 523-532.

Costin GE. Decoding and modulating the color of human skin. Cosmetic Chemist 2016. Available at:

http://d19cgyi5s8w5eh.cloudfront.net/eml/VPwvPaYmSi-

Uohf6UcNzhA?e=roger_mcmullen%40fdu.edu&a=Hn7-iRf_ToiDAzh-g4Tduw&f=&t=1.

Clippinger A.J., Hill E., Curren R., Bishop P. Bridging the gap between regulatory acceptance and industry use

of non-animal methods. ALTEX. 2016, 33: 453-458.

Barroso J., Ahn I.Y., Caldeira C., Carmichael P.L., Casey W., Coecke S., Curren R., Desprez B., Eskes C.,

Griesinger C., Guo J., Hill E., Roi A.J., Kojima H., Li J., Lim C.H., Moura W., Nishikawa A., Park H., Peng

S., Presgrave O., Singer T., Sohn S.J., Westmoreland C., Whelan M., Yang X., Yang Y., Zuang V.

International Harmonization and Cooperation in the Validation of Alternative Methods. Adv. Exp. Med.

Biol. 2016, 856: 343-386.

Curren R.D., Poth A., Raabe H.A. Implementation of New Test Methods into Practical Testing. Adv. Exp. Med.

Biol. 2016, 856: 189-203.

Hsu C.W., Hsieh J.H., Huang R., Pijnenbrug D., Khuc T., Hamm T., Zhao J., Lynch C., van Beuningen R.,

Chang X., Houtman R., Xia M. Differential Modulation of FXR Activity by Chlorophacinone and

Ivermectin analogs. Toxicol. Appl. Pharmacol. 2016; 313: 138-148.

Krishna G., Gopalakrishnan G., Goel S. Adult and Juvenile Toxicity Studies on Molindone Hydrochloride, a

Dopamine D2 Receptor Antagonist. Toxicology Mechanisms and Methods. 2017.

Stanton K., Kruszewski F.H. Quantifying the benefits of using read-across and in silico techniques to fulfill

hazard data requirements for chemical categories. Reg. Toxicol. Pharmacol. 2016; 81: 250-259.

Nakamura N., Gwenn M., Inselman A., Sloper D., Del Valle P.L., Sato T., Ogawa T., Hansen D. Evaluation of

Culture Time and Media in an in vitro Testis Organ Culture System. Birth Defects Research. Accepted

January 1, 2017 DOI:10.1002/bdr2.1002.

Abstracts

Krishna G., Gopalakrishnan G., Ganiger S., Krishnappa H., Kamala K. Urethane-Induced Carcinogenesis in

Tg.rasH2 Mice: a Comparative Study with Literature. American College of Toxicology Annual Meeting.

2016.

27

Krishna G., Gopalakrishnan G., Goel S., Yu G., White T. Battery of Reproductive Toxicology Studies

Supporting the Safety of a Dopamine Receptor Antagonist, Molindone. Submitted to the Teratology Society

Annual Meeting to be held in June 2017.

Lectures

Sheehan D., Diersen V., Pham R., Pidathala A., Lamm M., Krawiec L., Raabe H., Curren R., Costin G.E.

“Optimization of the Validated in vitro Skin Irritation Test (OECD TG 439) to Address the Assignment of

EPA Hazard Categories”. 5th

Annual Meeting of the American Society for Cellular and Computational

Toxicology, Raleigh, NC, September 29, 2016.

Kruszewski F.H. FDA Efforts to Finalize the OTC Monograph Regulations for Topical Antiseptic Drug

Products and Industry’s Response. Cleaning Products US 2016, November 9-11, 2-16, Washington, D.C.,

USA.

Rao D.B. “Bringing it All Together: Overview, Platform, and Discussion” for the Symposium on “Small

Compartment Toxicity: ‘CN VIII’: Hearing Loss, Tinnitus, and Balance Disorders. Invited Speaker at the

37th

Annual Meeting of the American College of Toxicology, Baltimore, MD, November 7, 2016.

Rao D.B. “Neuropathology Assessments in Toxicology Studies: Challenges and Principles”. Invited Speaker at

the 6th

Conference and Continuing Education Program on the Toxicologic Pathology of Nervous and

Musculoskeletal Systems, Society of Toxicologic Pathology – India, Pune, India, October 21, 2016.

Rao D.B. “Basic Neuroanatomy, Physiology and Chemistry for Neuropathologists”. Invited Speaker at the 6th

Conference and Continuing Education Program on the Toxicologic Pathology of Nervous and

Musculoskeletal Systems, Society of Toxicologic Pathology – India, Pune, India, October 21, 2016.

Posters

Kruszewski F.H. Risk Assessment Guidance for Enzyme-containing Products”. The International Society of

Exposure Science, October 9-13, 2016, Utrecht, Netherlands.

Training Course

Presentation (5 full day training course): Ross M., Walker T., Fritz J. Risk Assessment Training Experience

(RATE): Understanding and Application of Risk Assessments. Training course provided by the U.S.

Environmental Protection Agency, and organized by the Institute for International Environmental

Policy, Policy Research Center for Environment and Economy, on behalf of the Ministry of Environmental

Protection, P.R. China. 11/21/2016 - 11/25/2016, Beijing, P.R. China.