nadir ahmad, md, facs division head/associate professor of surgery otolaryngology-head & neck...
TRANSCRIPT
Nadir Ahmad, MD, FACSDivision Head/Associate Professor of Surgery
Otolaryngology-Head & Neck SurgeryCooper University Hospital & Medical School
Director, Head & Neck Cancer ProgramMD Anderson at Cooper Cancer Center
Management of Carotid Body Tumors
Carotid body tumors (CBT) Rare tumors (In US, 1-2 per 100,000) 60-65% of paragangilomas in H&N Overwhelmingly benign (90-95%). M:F ~1:1 Malignant CBT
Not a pathologic diagnosis, nor based on aggressive behavior Presence of metastases to cervical LNs or distant sites
Arise from carotid body with adventitia at medial aspect of carotid bifurcation Carotid body arises from neural crest Responds to acute fluctuations in concentrations of O2 and CO2, as well as
pH Protects organs from hypoxic damage thru release of neurotransmitters
that help regulate ventilator rate
Carotid Body Small, reddish-brown, oval structure in the
posteromedial aspect of the bifurcation Although considered subadventitial, actual
location is periadventitial Feeder vessels from
ascending pharyngealartery thru Mayer’sligaments
Innervated by Heringnerve branch of IX
Carotid body tumors (CBT) Classification
Sporadic Most common (85%)
Familial More common in younger pts (2nd-4th decade) More often bilateral and multiple (5% of CBT are bilateral) Gene for familial paragangliomas (PLG1) at the 11q23 locus Gene is transmitted in AD pattern with genomic imprinting
Affected man has 50% chance of having affected child Affected woman will not have affected child but can pass inactivated gene to next
generation
Hyperplastic Arises in patients with chronic hypoxia (ie. COPD, cyanotic heart disease),
including those living in high altitudes Occasionally associated with syndromes that have non-paraganglionic
tumors (MEN type II, VHL, NF-1)
CBT Typically present in mid-life as asymptomatic, non-
functional, lateral neck mass (soft, nontender, pulsatile)
Median age of onset – 45 yrs Slow-growing (doubling time ~7 yrs, median growth
of 0.83mm/yr Typically vertically fixed because of attachment to
carotid bifurcation (Fontaine sign). Can have associated bruit
~10% present with CN palsy IX, X, XI, superior laryngeal nerve, sympathetic chain Sxs: pain, dysphonia, dysphagia, Horner’s syn,
tongue paresis, shoulder dysfunction, FUO
CBT - Workup Functional tumors are rare
Check serum and urine catecholamines Symptoms similar to pheochromocytoma (paroxysmal HTN, palpitations,
diaphoresis)
CBT is an imaging diagnosis! Don’t do FNA. Initial imaging: US, color Doppler, CT with IV contrast, MR CT – splaying of ICA and ECA MRI – classic ‘salt and pepper’ appearance on T-1 weighted images
‘salt’ – slow flow or hemorrhage thru tumor
‘pepper’ – high velocity arterial branch flow voids
CBT – Historical perspective• Earliest successful resection in 1903 by Scudder• Significant complications up till 1960-70s
leading Hayes Martin to recommend against resecting extensive CBT (Shamblin III)
• Advances in imaging & surgical techniques have vastly improved safety & success of operation
CBT - Staging Shamblin classification – 3 types
Type I Small localized tumor easily dissected from adjacent vessels in peri-adventitial
plane Type II
Larger, more adherent tumors, with partial surrounding of vessels Type III
Completely surround/encase bifurcation
Pre-treatment details & counseling Factors to consider
Does the tumor need to be treated at all? What is consequence of leaving tumor alone?
What is the health & functional status of the patient? If considering treatment, surgery or XRT? If considering surgery, is preoperative embolization or balloon occlusion
test needed? Does a vascular surgeon need to be involved? What are the potential complications from XRT or surgery? ANSWERS:
Thorough understanding of the natural history/behavior of the tumor Thorough understanding of the risks of treatment as well as observation Thorough understanding of pre-treatment genetic counseling in the case of
familial tumors and pre-treatment physiologic management in the case of functional tumors
Thorough understanding of the surgical techniques that minimize morbidity in the event that surgery is selected by patient
Pre-treatment details & counseling MOST IMPORTANT POINT
Multidisciplinary management Surgeon (Head & Neck) Surgeon (Vascular) Interventional Radiologist Radiation Oncologist Neurologist Primary care physician Speech/Swallow Therapy
ENSURES THAT PATIENT HAS SOLID UNDERSTANDING OF TREATMENT OPTIONS AND POTENTIAL OUTCOMES AND RAMIFICATIONS, AND IS EMPOWERED WITH RESPECT TO THEIR CARE.
CBT - Management Observation is not recommended for most tumors as
further growth & compression can ensue. However, patient preference is paramount
In most centers in the US, surgery is preferred treatment modality. Surgery should be rendered in high-volume, tertiary care centers
Radiation therapy is generally reserved for elderly pts, poor surgical candidates, pts with multiple paraganglia in whom surgery would be highly morbid, and in pts with recurrent tumors Highly debated Often not radiosensitive (generally goal is not cure but to slow/halt progression) Can regrow after suppression Difficult to resect after XRT due to fibrosis. Concern for XRT-induced tumors (esp in young pts), carotid artery disease, ORN
CBT - Management Surgery
Ideal for tumors < 5cm & in young and/or healthy patients Difficult in larger, Shamblin type III tumors. Operative risk directly related to
size & extent of tumor Most often achieved via transcervical approach Can be associated with cranial nerve palsies (classically IX, X) so preop
counseling very important with contingency plan for rehab postop Must discuss other risks with patient (bleeding, infection, need for grafting,
stroke, death) Preoperative embolization +/- balloon occlusion test is controversial
Considered typically in Shamblin type II & III tumors to ↓ intraop bleeding Preop embolization done 48-72 hrs preop before fibrosis sets in Plethora of studies/reports do not show decrease in operative time, length of
hospital stay, intraop blood loss or increase in cranial neuropathies Helpful in larger type II and all type III tumors, including balloon occlusion test ~5% risk of stroke in CBT surgery
CBT - Management Surgery
For large tumors (Shamblin II & III), always involve vascular surgeon to be on standby should a bypass graft be needed. This rarely occurs but is also helpful from medico-legal perspective
Bilateral tumor resection associated with greater morbidity, including risk of baroreceptor reflex failure (labile BP difficult to control medically). Staging surgery is best option, with consideration of XRT if initial surgery resulted in complications)
Intraoperative details & pearls for successful operation Strong headlight illumination & loupe magnification Pre- and intra-op communication with Anesthesiologist Need good assistant! Bipolar cautery & suction (provision for 2 suction setup) Proximal & distal control of vessels Meticulous dissection in peri-adventitial plane (Plane of Gordon-Taylor) with
knife or atraumatic dissecting instrument (McCabe) – helps minimize problems Postoperative admission in ICU or Stepdown Unit to monitor for postop
hemorrhage or late CVA
CBT – Surgical complications Cranial neuropathy
Most commonly injured CN – Superior laryngeal branch of X Vagus injury - Aspiration/dysphagia/dysphonia XI – shoulder pain/weakness; XII – tongue weakness/dysphagia;
sympathetic chain – Horner’s syndrome
First Bite Syndrome Disruption of sympathetic innervation to ipsilateral parotid gland Difficult to treat – NSAIDs, Neuropathic pain meds (Gabapentin, TCA,
Tegretol), Botox A intraparotid injection, anticholinergics, reassurance
Baroreceptor reflex failure Loss of bilateral Hering nerves Labile HTN Sympatholytics/Clonidine
Stroke
Conclusions Multidisciplinary pre-treatment evaluation is
paramount to treatment success Surgery remains the best treatment modality Surgeon must employ meticulous surgical
technique Preoperative embolization & balloon occlusion
test is controversial & can be considered in larger tumors
Understanding postoperative complications is essential for patient counseling