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Most proteins in the ERare glycosylated
Proteins in cytosol arerarely glycosylated
original precursor oligosaccharide addedto most proteins in the ER
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Protein glycosylation in the rough ER
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Oligosaccharides are used as tags to mark the state of protein folding
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Misfolded proteins are exported from ER and destroyed
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Chapter 13
Intracellular Vesicular Traffic
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Roadmap ofprotein trafficinside cell
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Endocytic and secretory pathways
red = secretorygreen = endocyticblue = recycling
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5.14
Figure 5.14
figure 05-14.jpg
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Vesicular transport
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There are various types of coated vesicles
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Different coats are used for different transport steps in the cell
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Coated Pits are the sites of receptor mediated endocytosis
Clathrin protein
cytosol
Material to be taken up by cell
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Clathrin-coated pits and vesicles
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Structure clathrin triskelion
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Arrangement oftriskelion on surfaceof clathrin coatedvesicle
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Assembly and disassembly of clathrin coat
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Dynamin pinches clathrin coated vesicles from the membrane
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Electron micrograph from Drosophila mutant
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Resting Chemical Synapse
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Drosophila mutant can not recycle synaptic vesicles
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SNARE proteins guide vesicular transport
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Active Chemical Synapse
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Interaction of SNARE proteins while docking synaptic vesicle at nerve terminal
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Model for membrane fusion. Tight SNARE pairing forces water molecules from areabetween lipid bilayers
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