michael allan gropper, m.d., ph.d., fccp - uc san...

Michael Allan Gropper, M.D., Ph.D., FCCP Professor and Vice Chairman

Department of Anesthesia and Perioperative Care Director, Critical Care Medicine

Professor of Physiology Associate Investigator, Cardiovascular Research Institute

University of California San Francisco Address Critical Care Medicine University of California, San Francisco 505 Parnassus Avenue, M917 San Francisco, CA 94143-0624 Phone 415.353.1116 Fax 415.353.1990 Family Wife Lynn M. Westphal, M.D. Associate Professor of Obstetrics and Gynecology

Director, Women’s Health @ Stanford Acting Director, Reproductive Endocrinology and Infertility Director, Ovum Donation and Gestational Carrier Programs

Stanford University School of Medicine Children Hannah Rachel Education B.S. Physiology, University of California Davis 1979 Ph.D. Physiology, University of California San Francisco 1985 M.D. University of California Los Angeles School of Medicine 1989 Internship Internal Medicine, University of California San Francisco 1990 Residency Anesthesia, University of California San Francisco Hospitals 1993 Fellowship Critical Care Medicine, University of California San Francisco 1994 Positions Held Assistant Professor of Anesthesia and Perioperative Care 1994-2004 Assistant Professor of Physiology 1997-2000 Associate Investigator, Cardiovascular Research Institute 1999-present Associate Professor of Anesthesia and Perioperative Care 2000-2004 Associate Professor of Physiology 2000-2004 Director, Critical Care Medicine 2001-present Chair of Medical Quality, UCSF Medical Center 2002-2008 Professor of Anesthesia and Perioperative Care 2004-present Professor of Physiology 2004-present Vice Chairman of Anesthesia and Perioperative Care 2006-present Specialty Certification American Board of Anesthesiology: Certificate # 23700 1994 Special Qualification in Critical Care Medicine 1995 Licensure California # G71217 1990

Michael A. Gropper, M.D., Ph.D.

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Awards and Honors Caroline tum Suden Award of the American Physiological Society 1985 Foundation for Anesthesia Education and Research Young Investigator Award 1994 Excellence in Small Group Instruction, UCSF School of Medicine 1995 Chancellor’s Award for Distinction in Teaching 1996 Fellow, American College of Chest Physicians 1999 Associate Investigator, Cardiovascular Research Institute 1999 Member: California Academy of Medicine (elected) 2000 Clinical Faculty Teaching Award, UCSF School of Medicine 2001 Excellence in Small Group Teaching, UCSF School of Medicine 2001 Visiting Professor, University of Basel, Switzerland 2002 Association of University Anesthesiologists (elected) 2003 UCSF National Healthcare Quality Award: Glycemic Control in Critically Ill Patients 2004 UCSF National Healthcare Quality Award: Prevention of Ventilator Associated Pneumonia 2004 Excellence in Direct Teaching Award, UCSF Academy of Medical Educators 2005 Exceptional Physician Award, UCSF Medical Center 2006 2006 Kaiser Awards for Excellence in Teaching, Finalist, UCSF School of Medicine 2006 2008 Kaiser Award for Excellence in Teaching in the Inpatient Care Setting, Finalist 2008 University and Public Service Intramural Member, Infection Control Committee, Moffitt-Long Hospitals 1994-1996 Surgical Case and Hospital Mortality Committee 1996-2001 Committee on Animal Research, UCSF 1998-2000 Chair, Moffitt-Long Hospital Code Blue Committee, UCSF 1998-2000 Chair, Adult Critical Care Committee 1999-present Pharmacotherapeutic SWAT Team 2000-2001 UCSF Operating Room Committee 2000-2002 Chair, Moffitt-Long ICU Management Committee 2000-present Finance Committee, Department of Anesthesia 2000-present Executive Committee, Department of Anesthesia 2000-present UCSF Ethics Committee 2000-present UCSF Information Systems Steering Committee 2000-present UCSF Clinical Resource Management Committee 2001-present UCSF Executive Medical Board 2002-present Chair, UCSF Quality Improvement Executive Committee 2002-2008 Department of Medicine Endowed Chair Search Committee 2003 JCAHO Oversight Committee 2003-present Patient Safety Committee 2003-2006 Thoracic Surgery Quality Improvement Committee 2003-present Chief Nursing Officer Search Committee 2003 UCSF Continuing Medical Education Governing Board 2003-present Transfer Steering Committee 2004-present VAP/BSI Steering Committee 2004-present Critical Care Automation Task Force 2004-present Emergent Capacity Issues Task Force 2005 Rapid Response Team Working Group 2005 Co-Chair, Pulmonary and Critical Care Medicine Trauma Course 2005-present Steering Committee for Service Excellence 2005-present Donor by Cardiac Death Policy Workgroup 2005-present End of Life/Withdrawal of Life Support Committee 2005 Chief of Vascular Surgery Search Committee 2006 Hand Hygiene Task Force 2006-present Quality and Safety Officer Search Committee 2006 JCAHO XO (Executive Oversight) Committee 2006-2007 Periop Team Training Steering Committee 2007


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GME/Medical Center Resident Quality Education Committee 2007-present (University and Public Service, Intramural con’t) Surgical Team Steering Committee 2007 Associate CMO of Quality & Safety Officer Search Committee 2007 Ad hoc Patient Safety Committee 2007 Executive Medical Board Subcommittee 2007-present Director of Respiratory Care Services Search Committee 2007 Chief Medical Officer Search Committee 2008 Sedation Committee 2008 Chief Quality Officer Search Committee 2008 Chair, Central Line Taskforce Committee 2008 Co-Chair, Care Delivery Model Subcommittee 2008 Patient Mix Subcommittee 2008 Growth and Capacity Subcommittee 2008 Pediatric Critical Care Medicine Faculty Search Committee 2008 Department of Medicine 2008 Master Clinician Selection Committee 2008 Chair, Credentials Committee 2008-present Governance Advisory Council 2008-present Bylaws Committee 2008-present Administrative Advisory Group 2008 Chief of Division of Pulmonary Medicine Search Committee 2008 Critical Care Attending Task Force 2008 Committee on Interdisciplinary Practice 2008-present Extramural NIH Surgery, Anesthesia, Trauma Study Section - ad hoc reviewer 1995

Invited reviewer: Chest, Anesthesiology, Anesthesia & Analgesia, British 1995-present Journal of Anesthesia, American Journal of Medicine, Critical Care

Medicine, Canadian Journal of Anesthesia, Scandinavian Journal of Infectious Diseases, American Journal of Respiratory and Critical

Care Medicine, Intensive Care Medicine, Drugs, Journal of Cardiothoracic and Vascular Anesthesia, Journal of Clinical Anesthesia, Swiss Medical Weekly, Contributor, ABA Critical Care Medicine Certification Examination 1996-present

ABA Critical Care Medicine Certification Examination Committee 2000-present Reviewer, Swiss National Science Foundation 2001-present American Heart Association: Scientific Review Committee 2002-present

University Healthsystems Consortium: ICU Benchmarking Steering Committee 2002-2003 Physician Expert, CMRI Acute Myocardial Infarction Task Force 2003-2004 Editor, Faculty of 1000 2006-present ASCCA Education Committee 2007-present AUA Scientific Advisory Board Member 2007-2010 California Transplant Donor Network Medical Advisory Committee 2008-present

Research Awards and Grants Role of Water Channels in Lung Fluid Balance FAER Young Investigator Award (1994-1996) 1994 Direct Cost: $140,000 PI: Michael A. Gropper, MD, PhD Role in Project: PI UCSF Academic Senate Individual Investigator Award (1994-1995)


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1994 Direct Cost: $15,000 PI: Michael A. Gropper, MD, PhD Role in Project: PI UCSF Academic Senate Shared Equipment Grant (1995-1996) 1995 Direct Cost: $15,000 PI: Michael A. Gropper, MD, PhD Role in Project: PI Role of AchR in Critical Illness Polyneuropathy NIH Shannon Award (RO1) (1995-1997) 1995 Direct Cost: $100,000 Role in Project: Co-Investigator UCSF Research Allocation and Evaluation Committee (1997-1998) 1997 Direct Cost: $13,000 PI: Michael A. Gropper, MD, PhD Role in Project: PI Efficacy of rHuEPO In the Critically Ill Patient: A Randomized, Double-Blind, Placebo Controlled Trial Ortho Biotech (1999-2001) 1999 Direct Cost: $120,000 PI: Michael A. Gropper, MD, PhD Role in Project: PI Multicenter, Double Blind, Placebo Controlled, Randomized, Phase 3 Study of Tifacogin [Recombinant Tissue Factor Pathway Inhibitor (rTFPI/SC-59735)] in Severe Sepsis Chiron Corporation (2000-2002) 2000 Direct Cost: $100,000 PI: Michael A. Gropper, MD, PhD Role in Project: PI An Open-label Study of Recombinant Human Activated Protein C in Severe Sepsis Lilly Pharmaceuticals (2001-2003) 2001 Direct Cost: $97,000 PI: Michael A. Gropper, MD, PhD Role in Project: PI APC as an Anticoagulant in Continuous Renal Replacement Therapy Lilly Pharmaceuticals (2001-2003) 2001 Direct Cost: 5% salary Role in Project: Co-Investigator Determining the Virulence of P. Aeruginosa in Lung Infections in Critically Ill Patients UCSF Academic Senate (2002-2003) 2003 Direct Cost: $18,000 PI: Michael A. Gropper, MD, PhD Role in Project: PI Early Coagulation Abnormalities in Sepsis Genentech Inc. (2003-2004) 2003 Direct Cost: $50,000 PI: Michael A. Gropper, MD, PhD Role in Project: PI


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A Randomized, Double-Blinded, Active Controlled, Parallel Study to Establish the Comparative Safety and Efficacy of Ampofol and Diprivan for Sedation of Intensive Care Unit Patients Amphastar Pharmaceuticals (2003-2005) 2003 Direct Cost: $110,000 PI: Michael A. Gropper, MD, PhD Role in Project: PI A Safety Evaluation of Xigris [Drotrecogin alfa (activated)] in Hematopoietic Stem Cell Transplant Patients with Severe Sepsis Eli Lilly (2003-2005) 2004 Direct Cost (estimated): $65,000 PI: Michael A. Gropper, MD, PhD Role in Project: PI Acute Renal Failure Trial Network NIH/VA (2003-2008) VA Cooperative Study #530 2006 Direct cost: $320,000 Total Direct Costs: ($1,200,000 over 4 years) Role in Project: Co-PI (with Glenn Chertow, MD) Acute Lung Injury Specialized Clinical Center of Research NHLBI SCCOR P50HL074005-05 (9/2003 – 6/2008) 2005 Direct cost: $281,654 PI: Michael Matthay, MD Role in Project: Co-Investigator for Project 2 Therapeutic Investigations in ARDS NHLBI 46059-10 (9/2003 – 6/2008) 2005 Direct cost: $87,376 PI: Michael Matthay, MD Role in Project: Co-investigator Assessing and Treating Symptoms of Dying ICU Patients NIH 1 RO1 NR008247-01A2 (09/30/04-06/30/08) 2005 Direct Cost: $357,682 PI: Kathleen Puntillo Role in Project: Co-investigator A Phase 4, Randomized, Double-Blind, Multi-Center, Comparator Study Evaluating the Safety and Efficacy of Dexmedetomidine Compared to IV Midazolam in ICU Subjects Requiring Greater than Twenty-Four Hours of Continuous Sedation Hospira Pharmaceuticals (2005-2007) 2006 Direct Cost: $88,000 PI: Michael A. Gropper, MD, PhD Role in Project: PI Transfusion and Lung Injury NHLBI SCCOR 1P50HL081027-01 (09/2005 – 08/2010) 2006 Direct Cost (Project 2 only): $360,000 Total Direct Costs (5 years): $16,000,000 PI: Pearl Toy, MD Role in Project: PI for Project 2 Reducing Variation in Resource Utilization California Healthcare Foundation 2006-2007 Direct Cost: $200,000


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PI: Michael Ong, MD (UCLA) Role in Project: Participating Investigator

Michael A. Gropper, M.D., Ph.D. Invited Lectures/Presentations

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Invited Lectures/Presentations 1993 “Respiratory Failure”, American College of Cardiology, San Francisco, CA “Fiberoptic Intubation”, UCSF Changing Practice of Anesthesia Conference, San Francisco, CA “ICU Update”, Visiting Professor - Summit Medical Center, Oakland, CA 1994 “Adult Respiratory Distress Syndrome”, Sonoma Valley Hospital Surgery Grand Rounds, Sonoma, CA “Postoperative Care of Neurosurgical Patients”, UCSF Department of Neurosurgery, San Francisco, CA 1995 "Intravenous Sedation and Neuromuscular Blockade”, Sutter-Solano Hospital Grand Rounds, Solano, CA “Management of Shock", Washington Hospital, Fremont, CA “Inotropic Support of the Critically Ill Septic Patient”, UCSF Changing Practice of Anesthesia Conference,

San Francisco, CA “Techniques in Conscious Sedation”, Healdsburg General Hospital, Healdsburg, CA 1996 “Inflammatory Mechanisms of Acute Lung Injury”, Roche Bioscience, Palo Alto, CA “Preoperative Pulmonary Evaluation”, UCSF Department of Medicine, San Francisco, CA “Advances in Management of Acute Lung Injury”, UCSF Changing Practice of Anesthesia Conference,

San Francisco, CA 1997 “Inflammatory Mediators of Acute Lung Injury”, UCSF Department of Physiology Faculty Research Seminar,

San Francisco, CA “The Anesthesiologists Perioperative Role”, Los Gatos Community Hospital Medical Grand Rounds,

Los Gatos, CA “Workshop in Respiratory Failure”, American College of Cardiology: Update in Critical Care Cardiology,

San Francisco, CA “Inhaled Nitric Oxide in Clinical Practice”, UCSF Changing Practice of Anesthesia Conference, San Francisco, CA “Therapeutic Intervention in ARDS”, International Conference on Nasal and Pulmonary Drug Delivery,

Stockholm, Sweden “Update on Management of Sepsis Syndrome”, American Society of Anesthesiologists, San Diego, CA 1998 “Diagnosis and Management of Shock”, UCSF School of Nursing, San Francisco, CA “Pain Management and Conscious Sedation”, Los Gatos Community Hospital Medical Grand Rounds,

Los Gatos, CA “Emerging Therapies for ARDS”, Neurex Corporation, Menlo Park, CA “Noninvasive Ventilation for Respiratory Failure”, UCSF Changing Practice of Anesthesia Conference,

San Francisco, CA 1999 “Preoperative Pulmonary Evaluation”, UCSF Department of Medicine Pulmonary Conference,

San Francisco, CA “Management of Respiratory Failure”, American College of Cardiology: Update in Critical Care Cardiology,

San Francisco, CA "Update on Management of Respiratory Failure", Mills-Peninsula Hospital Grand Rounds, Burlingame, CA 2000 “Preoperative Pulmonary Evaluation”, UCSF Department of Medicine Pulmonary Conference. San Francisco, CA


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“Modern Management of ARDS”, VA Medical Center Department of Medicine Grand Rounds, San Francisco, CA

“Management of ARDS”, UCSF Intensive Cardiac Care Unit Rounds, San Francisco, CA “Management of Massive Hemoptysis”, UCSF Department of Medicine Conference, San Francisco, CA “Update in Critical Care Medicine”, UCSF Department of Urology Grand Rounds, San Francisco, CA “Ethical Dilemmas in Anesthesia and Critical Care”, UCSF Department of Anesthesia and Perioperative Care

Resident’s Retreat, Sea Ranch, CA “Management of Respiratory Failure”, International Teleconference Makati Medical Center, Manila,

Philippines and Singapore General Hospital, Singapore “Management of Severe Respiratory Failure”, Santa Rosa Memorial Hospital Trauma Division Grand

Rounds, Santa Rosa, CA “Advances in Ventilator Therapy for ARDS”, American College of Cardiology: Critical Care Cardiology,

San Francisco, CA “Update in Critical Care Medicine”, UCSF Department of Orthopedic Surgery Grand Rounds, San Francisco, CA “Clinical Trials in Critical Care Medicine”, UCSF Department of Medicine Pulmonary Grand Rounds,

San Francisco, CA “Ethical Dilemmas in the ICU”, UCSF Department of Nursing Grand Rounds, San Francisco, CA “Septic Shock: Can we Improve the Outcome?”, Mercy Pulmonary Institute/UC Davis Pulmonary Division,

Sacramento, CA “Update in Critical Care Medicine”, UCSF Department of Neurosurgery Grand Rounds, San Francisco, CA 2001 “Anemia in the ICU”, UC Davis Pulmonary and Critical Care Division, Sacramento, CA “Preoperative Pulmonary Evaluation”, UCSF Department of Medicine Pulmonary Grand Rounds, San Francisco, CA “Sepsis Clinical Trials at UCSF”, UCSF Department of Anesthesia and Perioperative Care Grand Rounds,

San Francisco, CA “The New ACLS Guidelines”, UCSF Department of Medicine Conference, San Francisco, CA “New Therapies for Severe Sepsis”, UCSF Department of Surgery Grand Rounds, San Francisco, CA “Perioperative Transfusion Therapy”, Broward General Hospital, Ft. Lauderdale, FL “Anemia and Transfusion in the ICU”, University of Arizona Medical Center Pulmonary Grand Rounds,

Tucson, AZ “New Targets for Severe Sepsis: The Coagulation Pathway”, Genentech, South San Francisco, CA “Sepsis 2001; Hope on the Horizon?”, UCSF Department of Medicine Grand Rounds, San Francisco, CA “Update in Intensive Care Medicine”, Kaiser Hospital Department of Medicine Grand Rounds, Oakland, CA “Small Tidal Volume Saves Lives”, UCSF Department of Anesthesia and Perioperative Care, The Changing

Practice of Anesthesia Conference, San Francisco, CA “Management of Respiratory Failure”, UCSF Fundamental Critical Care Support Program, San Francisco, CA “Management of Shock Syndromes”, UCSF Fundamental Critical Care Support Program, San Francisco, CA “Update in Critical Care Medicine”, Management of the Hospitalized Patient Symposium, San Francisco, CA “Inhaled Drug Delivery: Anesthesia Implications”, Aerogen Corporation Expert Panel Symposium, Sunnyvale,

CA “New Therapies for Severe Sepsis”, Advances in Pulmonary and Critical Care Medicine, San Francisco, CA “Advances in the Management of Sepsis”, Mills-Peninsula Hospital Grand Rounds, Burlingame, CA “The Emergent Treatment of Shock”, Topics in Emergency Medicine, San Francisco, CA “Perioperative Blood Management”, Keynote Address: Reduction of Perioperative Allogeneic Transfusion,

Memorial Sloan-Kettering Hospital, New York Blood Center, New York “Sepsis; New Views of Pathophysiology and Treatment”, San Francisco General Hospital Department of

Medicine Grand Rounds, San Francisco, CA 2002 “New Modes of Mechanical Ventilation”, Kantonsspital, University of Basel, Switzerland “New Therapies for the Management of Sepsis”, Kantonsspital, University of Basel, Switzerland


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“Update in ICU Medicine”, Seton Hospital Medical Grand Rounds, South San Francisco, CA “New Therapies for Management of Septic Shock”, UC Davis Infectious Disease Conference,

Sacramento, CA “New Therapies for Severe Sepsis”, Keynote Speaker: Critical Care Society of Argentina, Buenos Aires,

Argentina “New Therapies for Respiratory Failure”, Keynote Speaker: Critical Care Society of Argentina, Buenos Aires,

Argentina “Management of Sepsis Syndrome”, VA Medical Center Medical Grand Rounds, San Francisco, CA “Management of Sepsis; Focus on the Nephrologist”, National Kidney Foundation Annual Meeting,

Chicago, IL “Management of Severe Sepsis”, Community Hospital of Los Gatos, Los Gatos, CA “New Therapies for Severe Sepsis”, UCSF Advances in Internal Medicine, San Francisco, CA “ICU Update for the Non-Intensivist”, O’Connor Hospital Medical Grand Rounds, San Jose, CA “Clinical Trials in Sepsis Syndrome”, UCSF International Medicine Series International

Teleconference, Philippines, Singapore, Hong Kong “Evidence-based Management of Severe Sepsis”, Stanford University Medical Center Pulmonary Grand

Rounds, Stanford, CA “From Clinical Trial to Clinical Practice; Experience with drotrecogin alfa (activated) in the USA”, Frankfurt

Sepsis Symposium, Frankfurt, Germany “Resuscitation of Critically Ill Patients”, UCSF Department of Medicine: UCSF Intensive Care Medicine for the

Non-Intensivist, San Francisco, CA “Withdrawing Support: End of Life Issues in the ICU”, UCSF Department of Medicine, UCSF Intensive Care

Medicine for the Non-Intensivist, San Francisco, CA “Update in ICU Medicine”, UCSF Department of Medicine: Management of the Hospitalized Patient,

San Francisco, CA “Inflammation Interactions: Sepsis and the Coagulation System”, Society for Pediatric Anesthesia Annual

Meeting, Orlando, FL “Clinical Experience with Drotrecogin alfa activated”, American College of Chest Physicians, San Diego, CA “From the OR to the ICU: Improving Patient Outcomes”, Moderator: UCSF Department of Anesthesia and

Perioperative Care Grand Rounds, San Francisco, CA “Treating Patients with Severe Sepsis”, UCSF Department of Medicine: Advances in Pulmonary and Critical

Care Medicine, San Francisco, CA 2003 “From Clinical Trial to Clinical Practice: Experience with Drotrecogin Alfa (activated) in the USA”, European Society of Intensive Care Medicine, Davos, Switzerland “Evidence-Based Management of Critically Ill Patients”, European Society of Intensive Care Medicine,

Davos, Switzerland “Managing Critically Ill Patients”, UCSF Department of Medicine, San Francisco, CA "Impact of Implementation of a Mechanical Ventilation Weaning Protocol in Multiple Adult Critical Care Units",

Society of Critical Care Medicine, San Antonio, Texas “Evidence-Based Management of Critically Ill Patients”, Washington Hospital Medical Grand Rounds,

Fremont, CA “Update in ICU Medicine”, UCSF Department of Anesthesia and Perioperative Care Faculty Development

Seminar, San Francisco, CA “Resuscitation of Critically Ill Patients”, UCSF Department of Medicine: Intensive Care Medicine for Non-

Intensivists, San Francisco, CA “Ethical Dilemmas in Critical Care”, UCSF Department of Medicine: Intensive Care Medicine for Non-

Intensivists, San Francisco, CA “Update in ICU Medicine”, Management of the Hospitalized Patient, San Francisco, CA “Evidence-based Management of Severe Sepsis”, Recent Advances in Pulmonary and Critical Care

Medicine, San Francisco, CA “VEGF and Sepsis: Therapeutic Implications”, Genentech Inc., South San Francisco, CA “Sepsis”, Topics in Emergency Medicine, San Francisco, CA


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“Evidence-based Management of Severe Sepsis”, Maimonides Medical Center Department of Surgery Grand Rounds, Brooklyn, NY

2004 “Evidence-Based Prevention of Ventilator Associated Pneumonia”, University Healthsystems Consortium:

Respiratory Care Directors, Miami, FL Chair: Critical Care and Trauma Session, International Anesthesia Research Society, Tampa, FL “Update in Evidence Based Critical Care Medicine”, UCSF Department of Neurosurgery Grand Rounds,

San Francisco, CA “Medical Errors”, UCSF Department of Anesthesia and Perioperative Care Grand Rounds, San Francisco,

CA “Procedural Sedation for Non-anesthesiologists”, Pacific Coast Fertility Society, Palm Springs, CA “Evidence-Based Management of Severe Sepsis”, San Francisco General Hospital Department of Medicine

Grand Rounds, San Francisco, CA “Management of Critically Ill Patients: The Evidence”, UCSF Department of Medicine Grand

Rounds, Moffitt-Long Hospital, San Francisco, CA “Critical Care Medicine”, Review Course for ABIM Certification, San Francisco, CA “Airway Management and Paralytic Agents”, ACCP Critical Care Board Review Course, Orlando, FL “Management of Pain, Sedation, and Glycemic Control”, ACCP Critical Care Board Review Course, Orlando,

FL “Resuscitation of Critically Ill Patients”, Management of the Hospitalized Patient, San Francisco, CA “Evidence-Based Sepsis Management”, Recent Advances in Pulmonary and Critical Care Medicine,

San Francisco, CA “Evidence for Patient Safety Practices”, UCSF Department of Anesthesia and Perioperative Care, The

Changing Practice of Anesthesia Conference, San Francisco, CA “Update in Critical Care Medicine”, UCSF Department of Anesthesia and Perioperative Care, The Changing

Practice of Anesthesia Conference, San Francisco, CA “Evidence Based Management of Severe Sepsis”, Japanese Society of Clinical Anesthesia, Osaka, Japan “New Modes of Mechanical Ventilation”, American Society of Anesthesiologists, Las Vegas, NV “Novel Sepsis Therapies”, American Society of Anesthesiologists, Las Vegas, NV “Implementation of Evidence-based Practice in the ICU”, Maimonides Medical Center, Brooklyn, NY 2005 “Implementing the IHI 100,000 Lives ICU Strategies”, UCSF Department of Medicine: 9th Annual

Management of the Hospitalized Patient, San Francisco, CA “Treating the Patient with Sepsis: Pressors, Activated Protein C, and other Strategies”, UCSF Department of Medicine: 9th Annual Management of the Hospitalized Patient, San Francisco, CA “Improving ICU Outcomes (What Can We Do in the OR?)”, UCSF Department of Anesthesia and

Perioperative Care, The Changing Practice of Anesthesia Conference, San Francisco, CA “Preventing Hospital Acquired Infections”, UCSF 2005 Quality Forum, San Francisco, CA “Update in Critical Care Medicine”, UCSF Department of Vascular Surgery Grand Rounds, San Francisco,

CA “Acute Liver Failure: Supporting Other Organs”, Liver Intensive Care Group of Europe, Manchester, England Moderator: Postoperative Care of the Liver Transplant Patient, Liver Intensive Care Group of Europe,

Manchester, England “Review of Critical Care Medicine”, UCSF Department of Internal Medicine Board Review Course,

San Francisco, CA “Airway Management and Paralytic Agents”, American College Chest of Physicians Critical Care Board

Review Course, Scottsdale, AZ “Postoperative Management”, American College of Chest Physicians Critical Care Board Review Course,

Scottsdale, AZ “Sepsis: Goal Directed Therapy”, UCSF Division of Pulmonary and Critical Care Medicine, Department of

Medicine, and Department of Anesthesia and Perioperative Care Critical Care Medicine and Trauma Course, San Francisco, CA


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“Ventilator Strategies to Minimize Lung Injury”, American Society of Anesthesiologists Annual Conference, Atlanta, GA

“New Approaches to Mechanical Ventilatory Support”, American Society of Anesthesiologists Annual Conference, Atlanta, GA

“Update on Septic Shock”, 14th Asean Congress of Anesthesiologists, Vietnam Society of Anesthesiologists, Hanoi, Vietnam

2006 “Update in Critical Care Medicine”, Stanford University School of Medicine OB-GYN Grand Rounds,

Stanford, CA “Liver Transplantation Simulator Workshop”, Moderator: Liver Intensive Care Group of Europe, UCSF Simulation Course, San Francisco, CA “Evidence-Based Treatment of Severe Sepsis”, IARS 80th Clinical and Scientific Congress, San Francisco,

CA “Critical Care Medicine & Trauma – Organ Donors & Outcomes”, Moderator: Poster Discussion Rounds, IARS 80th Clinical and Scientific Congress, San Francisco, CA “Transfusion Related Acute Lung Injury”, Harvard Medical School/Massachusetts General Hospital Department of Anesthesia and Critical Care Ground Rounds, Boston, MA “Care of Adult Patients with Severe Sepsis”, UCSF Pediatric Critical Care Conference, San Francisco, CA “New Therapies for Severe Sepsis”, UCSF Division of Pulmonary and Critical Care Medicine,

Department of Medicine, and Department of Anesthesia and Perioperative Care, 2nd Critical Care Medicine and Trauma Course, San Francisco, CA

“Fluid and Blood Replacement: Recent Concepts”, 8th International Anesthesia Symposium, Rio de Janeiro, Brazil

“Recent Advances in Critical Care”, 8th International Anesthesia Symposium, Rio de Janeiro, Brazil “Sepsis: Evidence Based Treatment”, 8th International Anesthesia Symposium, Rio de Janeiro, Brazil “New Modes of Mechanical Ventilation”, 8th International Anesthesia Symposium, Rio de Janeiro, Brazil “Airway Management and Paralytic Agents”, 2006 ACCP Critical Care Review Course, Orlando, FL “Perioperative Management”, 2006 ACCP Critical Care Review Course, Orlando, FL “New Therapies for Sepsis”, UCSF Department of Pulmonary Medicine Grand Rounds, San Francisco, CA “Donation After Cardiac Death”, UCSF Department of Anesthesia and Perioperative Care, The Changing

Practice of Anesthesia Conference, San Francisco, CA “Evidence Based Management of Severe Sepsis”, UCSF Department of Medicine, 10th Annual Management

of the Hospitalized Patient, San Francisco, CA “Mechanical Ventilatory Support in 2006: Getting the Most from the Ventilator”, 2006 American Society of Anesthesiologists Annual Meeting, Chicago, IL “Transfusion Related Acute Lung Injury”, Contemporary Forums, Advanced Critical Care and Trauma

Conference, San Francisco, CA “Transfusion Related Acute Lung Injury”, 12th Asian Australasian Congress of Anaesthesiologists, Singapore “Evidence Based Practice in Critical Care”, 12th Asian Australasian Congress of Anaesthesiologists,

Singapore “New Therapies for Severe Sepsis”, Kaiser Permanente Medical Center Department of Internal Medicine

CME Noon Conference, San Francisco, CA 2007 “Quality and Safety Issues and How They Impact Practice in the ICU and ED”, UCSF Department of Nursing,

Critical Care/Trauma and Acute Care NP QA lecture, San Francisco, CA “Critical Care of the Obstetric Patient”, UCSF Department of Anesthesia and Perioperative Care, Obstetrical

Anesthesia, The Sol Shnider M.D. Obstetrical Anesthesia Meeting, San Francisco, CA “Update on Care of the Critically Ill Patient”, UCSF Department of Medicine Resident Lecture, San Francisco,

CA “New Approaches to Mechanical Ventilatory Support”, Winthrop University Hospital Department of

Anesthesia 2007 CME lecture series, Long Island, NY “Critical Care Update 2007: An Evidence-based Approach”, Maimonides Medical Center Surgical Grand

Rounds Conference, Brooklyn, NY


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“The Multidisciplinary ICU Team”, UCSF Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Department of Anesthesia and Perioperative Care, 3rd Critical Care Medicine and Trauma Course, San Francisco, CA

“Implementing the IHI: 100,000 Lives ICU Strategies”, Seton Medical Center Department of Medicine CME Rounds, Daly City, CA “Airway Management and Paralytic Agents”, 2007 ACCP Critical Care Board Review Course, Phoenix, AZ “Postoperative Management: Analgesia, Sedation, and Glycemic Control”, 2007 ACCP Critical Care Board

Review Course, Phoenix, AZ “Improving the Care of Critically Ill Adults”, 2nd Annual Northern California Pediatric Intensive Care Network Conference, Children’s Hospital & Research Center Oakland, CA “CRBSI in the ICU”, 10th Annual International Sepsis Forum 2007, Institut Pasteur, Paris, France “Evidence-Based Management of Sepsis”, UCSF Department of Medicine, 11th Annual Management of the

Hospitalized Patient, San Francisco, CA “Improving Quality and Safety in the ICU”, UCSF Department of Medicine, 11th Annual Management of the

Hospitalized Patient, San Francisco, CA “Mechanical Ventilation: What Every Anesthesiologist Should Know”, 2007 Society of Anesthesiologists

Annual Meeting, San Francisco, CA “The Future of Critical Care Medicine”, Foundation for Anesthesia Education and Research, Board of

Directors Meeting, San Francisco, CA “Management of Fulminant Hepatic Failure: The UCSF Experience”, International Liver Transplant Society

Annual Meeting, San Francisco, CA “The Role of the Anesthesiologist in Palliative Care”, 2007 American Society of Anesthesiologists Annual

Meeting, San Francisco, CA “Catheter Related Blood Stream Infection”, 2007 AACN Sepsis Symposium, University of Texas M.D.

Anderson Cancer Center, Houston, TX 2008 “Transfusion Related Acute Lung Injury”, Columbia University Medical Center Research Seminar, New York, NY “Improving the Care of Critically Ill Patients”, Columbia University Medical Center Grand Rounds, New York, NY “Management of Severe Sepsis: Update 2008”, Columbia University Medical Center Critical Care Grand Rounds, New York, NY “Improving the Care of Critically Ill Adults”, Columbia University Medical Center, Pediatric Critical Care

Consortium at Weill Cornell Medical College, New York, NY “Withdrawal of life support and end of life care in the ICU”, 14th Annual World Congress of Anesthesiologists:

Cancer Track Lecture Series, Cape Town, South Africa “Catheter Related Bloodstream Infection in the ICU”, 14th Annual World Congress of Anesthesiologists:

Catheter-related Blood Stream Infection Series, Cape Town, South Africa “Transfusion Related Acute Lung Injury”, Washington University Department of Anesthesia, Division of

Clinical and Translational Research Seminar, St. Louis, MO “Improving Outcomes in Critically Ill Patients”, Washington University Department of Anesthesia Grand

Rounds, St. Louis, MO “Transfusion Related Acute Lung Injury”, Vanderbilt University Medical Center Research Seminar, Nashville,

TN “Improving the Care of Critically Ill Patients”, Vanderbilt University Department of Anesthesia Grand Rounds,

Nashville, TN “Management of Severe Sepsis”, Mills-Peninsula Medical Center OCME, Burlingame, CA Moderator, Scientific Session, Association of University Anesthesiologists 55th Annual Meeting, Duke

University School of Medicine, Durham, NC “Improving Outcomes in Critically Ill Patients”, Washington Hospital Medical Staff Grand Rounds, Fremont,

CA “Current Risks and Benefits of Blood Transfusion”, California Society of Anesthesiologists 60th Annual

Meeting and Clinical Anesthesia Update, Universal City, CA


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“Update on Mechanical Ventilation”, California Society of Anesthesiologists 60th Annual Meeting and Clinical Anesthesia Update, Universal City, CA

“Preventing Catheter Related Bloodstream Infection – The Role of the Anesthesiologist”, California Society of Anesthesiologists 60th Annual Meeting and Clinical Anesthesia Update, Universal City, CA

“Ensuring Quality and Safety in the ICU”, UCSF Departments of Anesthesia and Perioperative Care, Medicine, and Surgery, 4th Annual Critical Care Medicine and Trauma Course, San Francisco, CA “Quality, Pay for Performance, and Critical Care”, UCSF Departments of Anesthesia and Perioperative Care, Medicine, and Surgery, 4th Annual Critical Care Medicine and Trauma Course, San Francisco, CA “Resuscitation of Shock”, 6th Annual Anesthesia Resident Refresher Course, Stanford Medical Center, Stanford, CA


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Visiting Professorships University of Basel, Switzerland, January 2002 Critical Care Society of Argentina, February 2002 Mt. Sinai School of Medicine - Maimonides Medical Center, Brooklyn, NY, December 2003 Kyoto Prefectural University of Medicine, Japan, October 2004 Harvard Medical School - Massachusetts General Hospital, Boston, MA April 2006 Maimonides Medical Center, Brooklyn, NY, May 2007 Columbia University Medical Center, New York, NY, February 2008 Washington University Medical Center, St. Louis, MO, April 2008 Vanderbilt University Medical Center, Nashville, TN, May 2008 Professional Activities State California Society of Anesthesiologists California Society of Medicine (Elected) National American Society of Anesthesiologists Society of Critical Care Medicine American College of Chest Physicians (Fellow) American Society of Critical Care Anesthesiologists Association of University Anesthesiologists (Elected) American Thoracic Society International International Anesthesia Research Society Podcast SCCM Pod-24 Implementing the Surviving Sepsis Campaign

url: http://www.sccm.org/PodCasts/SCCMCCP_030606_V4N4A26.mp3 March, 2006

Interviews for Publication “Medicare policy on withholding payment for hospital errors open to criticism: Hospital-acquired Infections”, Health Technology Trends, (6) Vol 19, No.10, October 2007

Michael A. Gropper, M.D., Ph.D. Bibliography (Peer Reviewed Publications)

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Bibliography Articles 1. Conhaim RL, Gropper MA and Staub NC. Effect of lung inflation on alveolar airway barrier protein

permeability in dog lung. J Appl Physiol; 55(4):1249–56, 1983. 2. Bhattacharya J, Gropper MA and Staub NC. Interstitial fluid pressure gradient measured by

micropuncture in excised dog lung. J Appl Physiol; 56(2):271–77, 1984. 3. Nagasaka Y, Bhattacharya J, Nanjo S, Gropper MA and Staub NC. Micropuncture measurement of lung

microvascular pressure profile during hypoxia in cats. Circ Res; 54:90–95, 1984. 4. Wiener-Kronish JP, Gropper MA and Matthay MA. ARDS: A syndrome caused by increased

microvascular permeability. J Resp Dis; 5(9):43–50, 1984. 5. Wiener-Kronish JP, Gropper MA and Lai-Fook SJ. Pleural pressures measured in dogs using a rib

capsule. J Appl Physiol; 59:597–02, 1985. 6. Gropper MA. Pulmonary microvascular sites of liquid filtration. Doctoral dissertation, Department of

Physiology, University of California San Francisco School of Medicine, July, 1985. 7. Findell PR, Mulcahey JJ, Shepard JM, Gropper MA, Bhattacharya J and Weiner RI. Direct measurement

of blood pressure within the long hypophysial portal blood vessels. Neuroendocrinology; 45:263–66, 1987.

8. Shepard JM, Gropper MA, Nicolaysen G, Staub NC and Bhattacharya J. Lung microvascular pressure

profile measured by micropuncture in anesthetized dogs. J Appl Physiol; 64(2):874–79, 1988. 9. Gropper MA and Matthay MA. Resolution of pulmonary edema. Hosp Physician; 24(4):70–74, 1988. 10. Gropper MA, Bhattacharya J and Staub NC. Non-linear filtration in isolated zone 1 and zone 3 dog lungs

at constant high alveolar pressure. J Appl Physiol; 65(1):343–49, 1988. 11. Berthiaume Y, Broaddus VC, Gropper MA, Tanita T and Matthay MA. Alveolar liquid and protein

clearance from normal dog lungs. J Appl Physiol; 65(2):585–93, 1988. 12. Wiener-Kronish JP, Broaddus VC, Albertine KH, Gropper MA, Matthay MA and Staub NC. The

relationship of pleural effusions to increased permeability pulmonary edema in anesthetized sheep. J Clin Invest; 82:1422–29, 1988.

13. Bhattacharya J, Gropper MA and Shepard JM. Lung expansion and the perialveolar interstitial pressure

gradient. J Appl Physiol; 66:2600-5, 1989. 14. Tanita T, Gropper MA, Staub NC, Koike K and Nakada T. Estimation of the filtration variables in the rat

lung. Nihon Kyobu Shikkan Gakkai Zasshi; 27(10);1168-72, 1989. 15. Raj JU, Hillyard R, Kaapa P, Anderson J and Gropper MA. Pulmonary vascular pressure profile in 2-3

week-old, 5-6 week old and adult ferrets. Resp Physiol; 82:307–16, 1990. 16. Wiener-Kronish JP, Gropper MA and Matthay MA. The adult respiratory distress syndrome: definition

and prognosis, pathogenesis and treatment. Br J Anaesth; 65:107-29, 1990. 17. Raj JU, Hillyard R, Kaapa P, Gropper MA and Anderson J. Pulmonary arterial and venous constriction

during hypoxia in 3- to 5-week old and adult ferrets. J Appl Physiol; 69(6):2183–89, 1990.


16

18. Gropper MA, Cohen NH. What to do in a blood pressure emergency. Contemporary OB/Gyn; 37:154-56, 1992.

19. Gropper MA, Wiener-Kronish JP and Hashimoto S. Cardiogenic pulmonary edema and unusual forms of

pulmonary edema. Clin Chest Med; 15:501-16, 1994. 20. Frigeri A, Gropper MA, Turck CW and Verkman AS. Immunolocalization of the mercurial-insensitive

water channel and glycerol intrinsic protein in epithelial cell plasma membranes. Proc Natl Acad Sci USA; 92:4328-31, 1995.

21. Frigeri A, Gropper MA, Kawashima M, Brown D and AS Verkman. Localization of MIWC and GLIP water

channel homologs in neuromuscular, epithelial and glandular tissues. J Cell Sci; 108:2993-02, 1995. 22. Umenishi F, Verkman AS and Gropper MA. Quantitative analysis of aquaporin mRNA expression in rat

tissues by RNase protection assay. DNA Cell Biol; 15(6):475-80, 1996. 23. Sawa T, Miyazaki H, Pittet JF, Widdicombe JH, Gropper MA, Hashimoto S, Folkesson HG, Debs R,

Forsayeth JR, Fox B and Wiener-Kronish JP. Intraluminal water increases expression of plasmid DNA in rat lung. Hum Gene Ther; 7:933-41, 1996.

24. Sawa, T, D Corry, MA Gropper, M Ohara and JP Wiener-Kronish. IL-10 improves lung injury and survival

in Pseudomonas aeruginosa pneumonia. J. Immunol; 159:2858-66, 1997. 25. Ohara M, Sawa T, Kurahashi K, Wiener-Kronish JP, Doshi V, Kudoh I and Gropper MA. Induction of

cyclooxygenase-2 in alveolar macrophages after acid aspiration: selective cyclooxygenase-2 blockade reduces interleukin-6 production. Anesthesiology; 88(4):1014-22, 1998.

26. Sawa T, Kurahashi K, Ohara M, Gropper MA, Doshi V, Larrick JW and Wiener-Kronish JP. Evaluation of

antimicrobial and lipopolysaccharide-neutralizing effects of a synthetic CAP-18 fragment against Pseudomonas aeruginosa in a mouse model. Antimicrob Agents Chemother; 42(12)3269-75, 1998.

27. Sawa T, Ohara M, Kurahashi K, Twining SS, Frank DW, Doroques DB, Long T, Gropper MA and Wiener-

Kronish JP. In vitro cellular toxicity predicts Pseudomonas aeruginosa virulence in lung infections. Infect Immun; 66:3242-49, 1998.

28. Kallet RH, Daniel BM, Gropper MA, and Matthay MA. Acute Pulmonary Edema following upper airway

obstruction; Case reports and brief review. Resp Care; 43(6):476-80, 1998. 29. Wiener-Kronish JP and Gropper MA. Halogenated anesthetics and the injured lung; Clouds on the

horizon? Anesthesiology; 88:1435-36, 1998. 30. Sawa T, Yahr TL, Ohara M, Kurahashi K, Gropper MA, Wiener-Kronish JP and Frank DW. Active and

passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury. Nat Med; 5(4):392-98, 1999.

31. Kurahashi K, Kajikawa O, Sawa T, Ohara M, Gropper MA, Frank DW, Martin TR and Wiener-Kronish JP.

The pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia in a rabbit model. J Clin Invest; 104:743–50, 1999.

32. Kindler CH, Verotta D, Gray AT, Gropper MA and Yost CS. Additive inhibition of nicotinic acetylcholine

receptors by corticosteroids and the neuromuscular blocking drug vecuronium. Anesthesiology; 9(3):821-32, 2000.


17

33. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the Acute Respiratory Distress Syndrome. N Engl J Med; 342(18):1301-08, 2000.

34. Yost CS, Matthay MA and Gropper MA. Etiology of acute pulmonary edema during liver transplantation: a

series of cases with anaylsis of the edema fluid. Chest; 119(1):219-23, 2001. 35. Liu L and Gropper MA. Bedside Assessment for delirium in the mechanically ventilated patient. J Crit

Illness; 17(9):330, 2001. 36. Savel RH, Yao EC and Gropper MA. Protective effects of low tidal volume ventilation in a rabbit model of

Pseudomonas aeruginosa-induced acute lung injury. Crit Care Med; 29(2):392-98, 2001. 37. Eisner MD, Thompson T, Hudson LD, Gropper MA et al. Efficacy of low tidal volume ventilation in patients

with different clinical risk factors for acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med; 164:231-36, 2001.

38. Ajayi T and Gropper MA. Methemoglobinemia. Pulm Perspect; 18:40-46, 2001. 39. Gropper MA. A momentary pause… Br J Anaesth; 86(6):746-49, 2001. 40. Campbell P and Gropper MA. Venous Air Embolism. Pulm Perspect; 19(1):01-03, 2002. 41. Liu L and Gropper MA. Respiratory and hemodynamic management after cardiac surgery. Curr Treat

Options Cardiovasc Med; 4(2):161-69, 2002. 42. Corwin HL, Gettinger A, Pearl RG, Gropper MA et al. Efficacy of recombinant human erythropoietin in

critically ill patients: a randomized controlled trial. JAMA; 288:2827-35, 2002. 43. Misset B, Gropper MA, and Wiener-Kronish JP. Predicting Mortality in ARDS: The Circulatory System

Knows Best. Crit Care Med; 31(3):980-81, 2003. 44. Shimabukuro DW and Gropper MA. Eyeing the usefulness of nonbronchoscopic BAL in evaluating

pneumonia. J Resp Dis; 24(6):243, 2003. 45. Liu L and Gropper MA. Postoperative analgesia and sedation in the adult intensive care unit : a guide to

drug selection. Drugs; 63(8):755-67, 2003. 46. Gropper MA and Wiener-Kronish JP. The alveolar epithelium: suspect or innocent bystander?

Anesthesiology; 98(1):03-04, 2003. 47. Abraham E, Reinhart K, Opal S, Gropper MA et al. Efficacy and safety of tifacogin (recombinant tissue

factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA; 290(2):238-47, 2003. 48. Shimabukuro DW, Sawa T and Gropper MA. Injury and repair in lung and airways. Crit Care Med;

31:S524–31, 2003. 49. Gropper MA. Sepsis and Hypothermia: call in the granulocytes? Anesthesiology; 99(5): 1041-43, 2003. 50. Gropper MA and Matthay MA. Look before you leap: how do intensivists improve care for critically ill

patients? Am J Med; 116(3):206-07, 2004.


18

51. Opal S, Laterre PF, Abraham E, Gropper MA et al. Recombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: Results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trial. Crit Care Med; 32(2):332-41, 2004.

52. Bernard GR, Margolis BD, Shanies HM, Gropper MA et al (Extended Evaluation of Recombinant Human

Activated Protein C United States Investigators). Extended evaluation of recombinant human activated protein C United States Trial (ENHANCE US): a single-arm, phase 3B, multicenter study of drotrecogin alfa (activated) in severe sepsis. Chest; 125(6):2206-16, 2004.

53. Looney MR, Gropper MA and Matthay MA. Transfusion-related acute lung injury: a review. Chest;

126(1):249-58, 2004. 54. Gropper MA. Evidence-based management of critically ill patients: analysis and implementation. Anesth

Analg; 99(2):566-72, 2004. 55. Singh G, Zhuo H, Brown R, Garcia O, Sosnowchik D, Kohn M, Misset B, Gropper MA, Sawa T, Glidden J

and Wiener-Kronish JP. Quantity of Pseudomonas (PA) Defines Lung Infections. Crit Care Med; 32:12(Suppl), 556, 2005.

56. Guglielmo BJ, Dudas V, Maewal I, Young R, Hilts A, Villmann M, Gibbs L, Gropper MA and Jacobs R.

Impact of a series of interventions in vancomycin prescribing on use and prevalence of vancomycin-resistant enterococci. Jt Comm J Qual Saf; 31(8):469-75, 2005.

57. Fee C and Gropper MA. Establishing a comprehensive, evidence-based protocol for the care of patients

with sepsis. Acad Emerg Med; 12(9):912-13, 2005. 58. Niemann CU, Behrends M, Quan D, Eilers H, Gropper MA, Roberts JP and Hirose R. Recombinant factor

VIIa reduces transfusion requirements in liver transplant patients with high MELD scores. Tranf Med; 16:91-100, 2006.

59. Gajic O, Gropper MA and Hubmayr, RD. Pulmonary edema after transfusion: How to differentiate transfusion-associated circulatory overload from transfusion-related acute lung injury. Crit Care Med; 34(5):109-113, 2006. 60. Taylor JM and Gropper MA. Critical care challenges in orthopedic surgery patients. Crit Care Med;

34(9):191-99, 2006. 61. Gropper MA. Multisystem organ failure: predicting the future. Anesthesiology; 107:6-7, 2007. 62. Wiener-Kronish J, Gropper MA. The epithelium in acute lung injury/acute respiratory distress syndrome. Current Opinion in Crit Care; 14:11-15, 2008. 63. Gropper MA, Liu L. Tracheostomy Protocol Compliance: Herding Cats? Crit Care Med; Jun;36(6):1959-

60, 2008. 64. Gropper MA, Yost, S. The Curse of the Drinking Class. Crit Care Med; Jun;36(6):1958-9, 2008. 65. The VA/NIH Acute Renal Failure Trial Network. Intensity of Renal Support in Critically Ill Patients with

Acute Kidney Injury. N Engl J Med; 359(1): 7-20, 2008. 66. Lipshutz AKM, Fee C, Schell H, Campbell L, Taylor J, Sharpe BA, Nguyen J, Gropper MA. Strategies for

Success: A PDSA Analysis of Three QI Initiatives in Critical Care. Joint Commission Journal on Quality and Patient Safety; 34(8):435-444, 2008.

67. Sullivan KR, Gropper MA. Laboratory Testing Guidelines in the ICU: Less Red and More Green. Crit Care


19

Med; In Press.

Michael A. Gropper, M.D., Ph.D. Bibliography (Abstracts)

20

Abstracts 1. Bhattacharya, J, Nagasaka Y, Gropper MA and Staub NC. Microvascular pressure after histamine

measured by the micropuncture and venous occlusion methods in the isolated dog lung. Physiologist; 25(4):264, 1982.

2. Conhaim RL, Gropper MA, Matthay MA and Staub NC. Perivascular fluid cuff size and protein

concentration in isolated and intact dog lung lobes inflated with protein solution. Physiologist; 25(4):312, 1982.

3. Gropper MA, Wiener-Kronish JP and Lai-Fook SJ. Pleural liquid pressure in upright dogs measured

through implanted rib capsules. Fed Proc; 42(5):1270, 1983. 4. Bhattacharya J, Nagasaka Y and Gropper MA. Post-venular pressure drop determined by

micropuncture of isolated perfused dog lungs in zone 3. Fed Proc; 42(3):491, 1983. 5. Wiener-Kronish JP, Gropper MA, Lai-Fook SJ, Price DC and Staub NC. Clearance of tracer protein from

small hydrothoraces in anesthetized spontaneously breathing dogs. Fed Proc; 42(5):1271, 1983. 6. Nagasaka Y, Bhattacharya J, Gropper MA, Staub NC and Nanjo S. The site of hypoxic vasoconstriction

in isolated cat lung perfusion. Jap J Chest Dis; April, 1983. 7. Bhattacharya J, Nagasaka Y and Gropper MA. Venular pressures measured by micropuncture of

isolated perfused dog lungs in Zone 2. Proc XXIX Cong Int Union Physiol Sci; Australia, 1983. 8. Gropper MA, Bhattacharya J, Eaton A and Staub NC. Filtration rate in relation to alveolar pressure in

isolated dog lung. Fed Proc; 43(4):1032, 1984. 9. Bhattacharya J, Nagasaka Y and Gropper MA. Venular pressure after norepinephrine, measured by

micropuncture of isolated perfused dog lungs. Fed Proc; 43(4):918, 1984. 10. Wiener-Kronish JP, Albertine KH, Gropper MA and Staub NC. Pleural effusion in sheep caused by oleic

acid lung injury. Fed Proc; 43(4):1032, 1984. 11. Bhattacharya J, Eaton A and Gropper MA. Filtration rate in single microvessels of excised dog lungs

measured by the split-drop technique. Abst 170, Third World Congress for Microcirculation, Oxford, England; 1984.

12. Gropper MA, Shepard JM, Staub NC and Bhattacharya J. Measurement of albumin concentration in

nanoliter samples of lung liquids collected by micropuncture. Microvasc Res; 29(2):223, 1985. 13. Bhattacharya J, Gropper MA and Shepard JM. Measurement of filtration rate in single lung microvessels

by the split drop technique. Microvasc Res; 29(2):208, 1985. 14. Gropper MA, Shepard JM, Bhattacharya J and Staub NC. Alveolar pressure does not affect filtration rate

in isolated or intact dog lungs. Fed Proc; 44(6):1911, 1985. 15. Bhattacharya J, Gropper MA and Shepard JM. Micropuncture measurements of interstitial pressures in

excised dog lungs at different levels of lung inflation and lung edema. Fed Proc; 44(6):1911, 1985. 16. Shepard JM, Gropper MA, Staub NC and Bhattacharya J. Micropuncture measurement of lung

microvascular pressures in open thorax anesthetized dogs. Fed Proc; 44(6):1759, 1985. 17. Findell PR, Mulcahey JJ, Shepard JM, Gropper MA, Bhattacharya J and Weiner RI. Direct measurement

of blood pressure within the long hypophysial portal blood vessels. Endocrinology, 1985.


21

18. Gropper MA, Shepard JM and Staub NC. Arterial and venous leakage in zone 1 dog lung lobes give equal interstitial albumin concentrations. J Physiol (Lond), 1985.

19. Shepard JM, Gropper MA, Fike C, Staub NC and Bhattacharya J. Micropuncture measurement of

microvascular pressures in the intact dog lung under zone 3 conditions. Physiologist; 28:348, 1985. 20. Nicolaysen G, Gropper MA, Staub NC and Shepard JM. Lung surface blood flow during micropuncture

experiments. Physiologist; 28:348, 1985. 21. Gropper MA, Shepard JM, Staub NC and Bhattacharya J. Measurement of albumin concentration in

nanoliter samples of lung liquids collected by micropuncture. Fed Proc; 45(4):1159, 1986. 22. Wiener-Kronish JP, Broaddus VC, Gropper MA, Albertine KH and Staub NC. Pleural effusions

associated with oleic acid lung injury originate from the lung. Am Rev Resp Dis; 135(4):A191, 1987. 23. Wiener-Kronish JP, Broaddus VC, Gropper MA, Albertine KH and Staub NC. Evidence for visceral

pleural inflammation using a plastic bag to collect liquid. Fed Proc; 46(4):1424, 1987. 24. Tanita T, Gropper MA, Eaton A and Staub NC. Estimation of filtration variables in the isolated zone 1

rat lung using a new approach. Fed Proc; 46(4):1421, 1987. 25. Matthay MA, Tanita T, Onizuka M, Broaddus VC, Gropper MA and Berthiaume Y. Alveolar liquid and

protein clearance from the normal canine lung. Fed Proc; 46(3):814, 1987. 26. Gropper, MA, Tanita T and Staub NC. Effect of alveolar pressure and vascular pressures on filtration

rate in isolated rat lungs under zone 1 conditions. Fed Proc; 46(4):1421, 1987. 27. Tanita T, Gropper MA and Staub NC. Estimation of filtration coefficient using different methods in

isolated zone 3 rat lungs. Fed Proc; 2(5):A1293, 1988. 28. Hillyard R, Raj JU, Gropper MA, Anderson J and Kaapa P. Pulmonary vascular pressure profile in

neonatal and adult ferrets. Fed Proc, 1990. 29. Raj JU, Hillyard R, Gropper MA, Anderson J and Kaapa P. Effect of Hypoxia on segmental ascular

resistance in lungs of neonatal ferrets. Fed Proc, 1990. 30. Gropper MA, Frigeri A, Hasegawa H and Verkman AS. Extrarenal expression of WCH-CD water

channels in rat conjunctival and ependymal cells. Mol Biol Cell; 5:319a, 1994. 31. Frigeri A, Gropper MA and Verkman AS. Tissue distribution of MIWC and GLIP water channel homologs

detected by immunocytochemistry. Biophys J; 68(2):P119, 1995. 32. Gropper MA, Frigeri A and Verkman AS. Localization of MIWC and CHIP water channel homologs in rat

trachea and lung. Am J Resp Crit Care Med; 151(4), A179, 1995. 33. Sawa T, Miyazaki H, Gropper MA, Debs R, Hashimoto S, Pittet JF and Wiener-Kronish JP. Transfection

efficiency in to the lung using pGT145 is improved when the plasmid is delivered in hypotonic solutions. Clin Res, 1995.

34. Verkman AS, Farinas J, Frigeri A, Gropper MA, Ma T, Matthay MA, Shi L-B, Tamarappoo BK, Umenishi

F, van Hoek AN and Yang B. Molecular mechanisms of water transport across mammalian cell membranes. Proc 1st World Cong of Neurohypoph and Vasopressin. Tochigi, Japan, 1995.

35. Umenishi F, Frigeri A, Verkman AS and Gropper MA. Tissue-specific expression of water channels in rat

by RNase protection assay and immunocytochemistry. J Am Soc Nephrol 1995.


22

36. Carter EP, Matthay MA, Folkesson H, Gropper MA, Farinas J and Verkman AS. High transalveolar

water permeability in intact mouse lung measured by a novel surface fluorescence method. Am J Resp Crit Care Med; 153(4):A506, 1996.

37. Sawa T, Corry D, Gropper MA, Ohara M and Wiener-Kronish JP. IL-10 prevents death from fatal

pseudomonas lung infection. Mol Biol Cell, 1996. 38. Ohara M, Sawa T, Wiener-Kronish JP and Gropper MA. Pro-inflammatory mediator expression in a

murine model of acute lung injury. Anesth Analg; 84: S589, 1997. 39. Ohara M, Sawa T, Wiener-Kronish JP and Gropper MA. The role of cyclooxygenase-2 in murine acid

aspiration lung injury. Am J Resp Crit Care Med; 155(4):A466, 1997. 40. Sawa T, Kurahashi K, Ohara M, Gropper MA, Larrick JW and Wiener-Kronish JP. Effects of a synthetic

C-terminal fragment of CAP18 on Pseudomonas induced lung injury. Am J Resp Crit Care Med; 155(4):A469, 1997.

41. Kurahashi K, Sawa T, Ohara M, Kudoh I, Gropper MA, Shanks R and Wiener-Kronish JP. Beneficial

effect of recombinant interleukin-10 on Pseudomonas aeruginosa pneumonia in anesthetized rabbits. Am J Resp Crit Care Med; 155(4):A469, 1997.

42. Kurahashi K, Sawa T, Ohara M, Kajikawa O, Martin TR, Gropper MA and Wiener-Kronish JP.

Interleukin-10 improves bacteremia and shock in Pseudomonas aeruginosa pneumonia in rabbits. J Invest Med; 116A, 1998.

43. Sawa T, Ohara M, Kurahashi K, Gropper MA and Wiener-Kronish JP. The rapid upregulation of

Interleukin-10 in cytotoxic Pseudomonas aeruginosa pneumonia. Cold Spring Harbor Symposium Microbial Pathogenesis, 1997.

44. Ohara M, Sawa T, Kurahashi K, Yahr TL, Frank DW, Wiener-Kronish JP and Gropper MA.

Pseudomonas aeuruginosa inhibits Fc receptor-mediated phagocytosis. J Invest Med; 46:228S, 1998. 45. Sawa T, Ohara M, Kurahashi K, Yahr TL, Gropper MA, Frank DW, and Wiener-Kronish JP.

Pathogenesis of acute lung injury caused by Pseudomonas aeruginosa - major contribution of Type III secretory system. J Invest Med; 46:232S, 1998.

46. Sawa T, Ohara M, Kurahashi K, Twining SS, Frank DW, Gropper MA and Wiener-Kronish JP. Lung

epithelial injury caused by quorum-sensing Pseudomonas aeruginosa strains. Am Soc Microbiol, 1998. 47. Ohara M, Sawa T, Kurahashi K, Wiener-Kronish JP and Gropper MA. Localization of COX-1 and –2 in

murine lung after acute lung injury. FASEB J; A181, 1998. 48. Kurahashi K, Sawa T, Ohara M, Kajikawa O, Gropper MA, Martin TR and Wiener-Kronish JP. Interleukin

10 improves bacteremia and survival in septic rabbits via reticuloendothelial phagocytes. FASEB J; A1071, 1998.

49. Sawa T, Ohara M, Kurahashi K, Gropper MA, Frank DW and Wiener-Kronish JP. Rapid IL-10

upregulation in lung in cytotoxic Pseudomonas aeruginosa pneumonia. FASEB J; A1071, 1998. 50. Savel RH, Yao EC, Sawa T and Gropper MA. Low tidal volume ventilation protects against indirect injury

in a model of acute bacterial lung injury. Am J Resp Crit Care Med, 1999. 51. Daniel B, Wong B, Barba J and Gropper MA. "Impact of Implementation of a Mechanical Ventilation

Weaning Protocol in Multiple Adult Critical Care Units" Society of Critical Care Medicine, San Antonio,


23

TX, 2003. 52. Schell H and Gropper MA. ICU Discharge Checklist results in Decreased Invasive Catheter Use.

University Healthsystems Consortium Dallas, TX, 2003. 53. MacDougall C, Mendezm M, Dudas V, Jacobs RA, Gropper MA and Guglielmo BJ. Comparative

Demographics of Patients Approved or Denied the Use of Activated Protein C. Am Soc Microbiol, 2004. 54. Schell H, Sullivan M, Bijani A, Masharani and Gropper MA. Glycemic Control in the ICU: Implementation

Strategy and Outcomes. NTI: Am Assoc Crit Care Nursing, Orlando, FL, 2004. 55. Ong MK, Escarce JJ, Ang A, Xiong W, Auerbach AD, Chun A, Davidson B, Ganiats TG, Greenfield S,

Gropper M, Malik S, Romano PS, Mangione CM. Comparison of methods examining hospital use variation among elderly heart failure patients. Society of General Internal Medicine, 2008.

Michael A. Gropper, M.D., Ph.D

Books Edited Handbook of Conscious Sedation. Michael A. Gropper and Jeanine P. Wiener-Kronish, eds,

Hanley and Belfus, Philadelphia, PA, 2001.

Books Reviewed Critical Care: Physiology and Management, by Shishir Kumar Maithel and Jonathan F. Crichlow. Critical Care Medicine 34(10):2705, 2006. Book Chapters 1. Gropper MA and Matthay MA. Acute Lung Injury: Advances in diagnosis, pathophysiology and treatment.

In: Annual Review of Pulmonary and Critical Care Medicine. Hanley and Belfus. Philadelphia, 1989.

2. Gropper MA, Matthay MA and Wiener-Kronish JP. The adult respiratory distress syndrome: diagnosis, pathophysiology and treatment. In: Pulmonary Care of the Surgical Patient, Hanowell & Junod eds. Futura Co. New York, 139-182, 1993.

3. Gropper MA. Sepsis and Multi-system Organ Failure. In: Annual Review of Pulmonary and Critical Care Medicine. Hanley and Belfus. Philadelphia, 1993.

4. Gropper MA and Wiener-Kronish JP. Adult Respiratory Distress Syndrome. In: Critical Care Medicine-Perioperative Management, M.J. Murray ed. Raven Press. Philadelphia, 1997.

5. Verkman AS, Yang B, Shi LB, van Hoek AN, Farinas J, Gropper MA, Matthay MA, Tamarappoo B,

Umenishi F and Ma T. Water Channel Structure and Function. Vasopressin. Elsevier Science. Amsterdam, 1996.

6. Wiener-Kronish JP, Sawa T, Kurahashi K, Ohara M and Gropper MA. Pulmonary edema due to

Pseudomonas aeruginosa. In: Pulmonary Edema, M Matthay and D Ingbar eds. Marcel Dekker. Basel, 1998.

7. Pardo M and Gropper MA. General approach to the critically ill patient. In: Critical Care Secrets, P Parsons and JP Wiener-Kronish eds. Hanley & Belfus, Philadelphia, 1998.

8. Sawa T, Wiener-Kronish JP and Gropper MA. Injury and Inflammation. In: Atlas of Anesthesia; Scientific Principles of Anesthesia, D. Schwinn ed. Churchill Livingstone, Philadelphia, 1998.

9. Gropper MA and Wiener-Kronish JP. Postoperative Care. In: Hospital Medicine, RM Wachter ed. Williams and Wilkins, Philadelphia, 1999.

10. Gropper MA and Lisco SJ. The Hospitalist Movement: Is There a Place for Anesthesiologists? In: Anesthesiology Clinics of North America. WB Saunders. 17(2):445-452, 1999.

11. Niemann C, and Gropper MA. Pharmacology of Conscious Sedation. In: Conscious Sedation, JP

Wiener-Kronish and MA Gropper eds. Hanley and Belfus, Philadelphia, 2001. 12. Matthay MA, Weiner-Kronish JP, Cheng I and Gropper MA. Acute Lung Injury and Acute Respiratory

Distress Syndrome. In: Critical Care Medicine: Perioperative Management, eds: R. Pearl et al. Lippincott Williams and Wilkins, In press, 2002.

13. Liu L, and Gropper MA. Postoperative Sedation in the Intensive Care Unit: A guide to drug selection.

In: Drugs. In press, 2002.

Michael A. Gropper, M.D., Ph.D. Bibliography (Book Chapters)

25

14. Savel R and Gropper MA. Inotropes and Vasopressors. In: Critical Care Secrets, 2nd Edition, P Parsons and JP Wiener-Kronish eds. Hanley & Belfus, Philadelphia, 2002.

15. Widrich J and Gropper MA. Sepsis Syndrome. In: Critical Care Secrets, 2nd Edition, P Parsons and JP

Wiener-Kronish eds. Hanley & Belfus, Philadelphia, 2002. 16. Pardo M and Gropper MA. Approach to the Critically Ill Patient. In: Critical Care Secrets, 2nd Edition, P

Parsons and JP Wiener-Kronish eds. Hanley & Belfus, Philadelphia, 2002. 17. Chen H and Gropper MA. Total Hip Arthroplasty. In: Manual of Anesthesia Practice, Pardo and Sonner

eds. Pocketmedicine.com, New York, 2004. 18. Chen H and Gropper MA. Kidney Transplantation. In: Manual of Anesthesia Practice, Pardo and

Sonner eds. Pocketmedicine.com, New York, 2004. 19. Savel RH, Wiener-Kronish JP and Gropper MA. Postoperative Care. In: Hospital Medicine, 2nd Edition,

RM Wachter ed. Williams and Wilkins, Philadelphia, 2004. 20. Savel RH, Gropper MA, Macura JM and Lazzaro RS. Management of the Critically Ill Bariatric Patient.

In: Up To Date v.12.2, 2004. 21. Gropper MA and Liu LL. Overview of Critical Care Medicine. In: Miller’s Anesthesia, 6th Edition, RD

Miller ed. Churchill Livingstone, Philadelphia, 2005. 22. Savel R, Matthay MA and Gropper MA. Managing the Patient with Shock, Sepsis, and Multiple Organ

Failure. In: Chest Medicine: Principles of Pulmonary and Critical Care Medicine 5th Edition, RB George, RW Light, MA Matthay and RA Matthay eds. 2005.

23. Savel RH, Gropper MA, Macura JM and Lazzaro RS. Management of the Critically Ill Bariatric Patient I

and II. In: Up To Date, 2005. 24. Yanakakis M and Gropper MA. Diagnosis and Management of Acute Respiratory Failure.

In: Trauma: Resuscitation, Anesthesia, and Critical Care, Wilson, Grande and Hoyt eds. Marcel Dekker, New York. In press, 2006.

25. Campbell, L and Gropper, MA. Critical Care Medicine. In: Basics of Anesthesia, 5th Edition, RK

Stoelting and RD Miller eds. Churchill Livingstone, Philadelphia, 2006. 26. Liu, L and Gropper, MA. Mechanical Ventilatory Support in 2007: Getting the Most from the Ventilator.

In: Current Reviews in Clinical Anesthesia 27(18), F Moya ed, Current Reviews, Florida 2007. 27. Sullivan, K and Gropper MA. Mechanical Ventilatory Support in 2006: Getting the Most from the

Ventilator. In: ASA Refresher Courses in Anesthesiology (Volume 35), 2007. 28. Munnur, U, Bandi, V and Gropper, MA. Airway Management and Mechanical Ventilation in Pregnancy.

In: Pulmonary Problems in Pregnancy: Clinical and Research Aspects, K Rosene-Montella and G Bourjeily eds. Humana Press Inc., New Jersey, 2007.

29. Savel, RH, Gropper, MA, Macura JM, Lazzaro, RS. Management of the Critically Ill Bariatric Patient I

and II. In: Up to Date, 2007.

michael allan gropper, m.d., ph.d., fccp - uc san...

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