medt8002 blood flow measurement by doppler technique hans torp institutt for sirkulasjon og...
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MEDT8002
Blood flow measurement by Doppler technique
Hans Torp
Institutt for sirkulasjon og medisinsk bildediagnostikk
Hans TorpNTNU, Norway
Pulsed and continuous wave DopplerPulsed and continuous wave Doppler
• Dopplershift from moving scatterersDopplershift from moving scatterers
• Stocastic signal modelStocastic signal model
• Clutter filteringClutter filtering
• Spectrum analysisSpectrum analysis
• Two dimensional signal modelTwo dimensional signal model
Ultralyd DopplerUltralyd Doppler
Ultralyd probe
Lyden forandrer frekvens ved bevegelseLyden forandrer frekvens ved bevegelse
oo
Bilens hastighet: 70 km/time ~ 6% av lyd-hastighet
Ét halvtone-trinn i 12-toneskalaen: 2 = 5.94 %
Endring i frekvens (turtall): 6% + 6% = 12 %
1/12
Hans TorpNTNU, Norway
Fartskontroll på E6 ved HeggstadmoenFartskontroll på E6 ved Heggstadmoen
0 50 100 150 200 250 3000
50
100
150
200
250
300
frekvens [Hz]Motorsykkelens turtall 0.5*(f1+f2) = 140.3 HzDopplerskift: +/- 9.55 Hz ~ +/- 6.8 %Motorsykkelens fart: 340 * 6.8/100 *3.6 = 83.3 km/h
Fartsgrense = 80 km/h
Frekvensspekter før passeringFrekvensspekter etter passering
Ultralyd DopplerUltralyd Doppler
Ultralyd probe
Dopplerskift fd = fo v/cDopplerskift fd = fo v/c + fo v/c = 2 fo v/c
Signal processing Signal processing for CW Dopplerfor CW Doppler
fofrequency
fo+fd0 frequencyfd0
Hans TorpNTNU, Norway
Matlab: cwdoppler.m
Blood velocity calculated from Blood velocity calculated from measured Doppler-shiftmeasured Doppler-shift
fd = 2 fo v cos() / c
v = c/2fo/cos() fd
fd : Dopplershiftfo : Transmitted frequencyv : blood velocity
: beam angle c : speed of sound (1540 m/s )Hans Torp
NTNU, Norway
time
Velocity
CW/PW Doppler blood flow meterCW/PW Doppler blood flow meter
PEDOF developed in Trondheim 1976
Blood velocity Mitral inflow
Normal relaxation
Delayed relaxation
Hans TorpNTNU, Norway
Angelsen & Kristoffersen PW&CW Dopper PEDOF - 1976
HolenVelocity -> Pressure gradientLiv Hatle: Clinical practice
Cardiac Doppler in TrondheimCardiac Doppler in Trondheim
Continous Wave DopplerContinous Wave Doppler
ø
Single transducerPW
Double transducerCW
ø
transmit
recieve
Velocity profile, v
Artery
Range cell
Observation region in overlap of beams
Signal from all scattererswithin the ultrasound beam
Pulsed Wave DopplerPulsed Wave Doppler
Signal from a limited sample volume
ø
Single transducerPW
Double transducerCW
ø
transmit
recieve
Velocity profile, v
Artery
Range cell
Observation region in overlap of beams
Hans TorpNTNU, Norway
Matlab: pwdoppler.m
a)
b)
10-08/12pt
Hans TorpNTNU, Norway
Signal from a large number of red blood cellsSignal from a large number of red blood cellsadd up to a Gaussian random processadd up to a Gaussian random process
G ()e
10-11/12pt
Hans TorpNTNU, Norway
Power spectrum of the Doppler signal Power spectrum of the Doppler signal represents the distribution of velocitiesrepresents the distribution of velocities
Doppler spektrumDoppler spektrum
frequ
ency
time
spec
tral
am
plit
ude
Hans TorpNTNU, Norway
Doppler spectrum analysis:Doppler spectrum analysis:Different velocities separated in frequencyDifferent velocities separated in frequency
Nyquist limit in Pulsed wave DopplerNyquist limit in Pulsed wave Doppler
Nyquist-limit
DopplerDoppler spectrum spectrumSubclavian ArterySubclavian Artery
Velocity waveform restoredby stacking
Tidsvindu-lengde ved spektralanalyseTidsvindu-lengde ved spektralanalyse
Performance of the spectrum sonogram as a function of window length. Upper left: 150 points, upper right: 64 points, lower left: 32 points, and lower right: 16 points. The window type is Hamming and the degree of overlap is 75% in all pictures.
Resolution in Resolution in Doppler spectrum analysisDoppler spectrum analysis
-100
-50
50
100
Δ T
Δ v
Δv *ΔT = λ / 2
Minimum dot area in the spectrum display: Δv *ΔT
Ultrasound wavelength: λ
Doppler spectrumDoppler spectrumVelocity resolutionVelocity resolution
Blood flow velocityfo=2 MHz ~ λ = 0.76mmΔT = 10 msecΔv = 3.6 cm/sec ~ 0.7 % of peak syst. velocity
Myocardial velocityfo=3.5 MHz ~ λ = 0.4 mmΔT = 20 msecΔv = 2 cm/sec ~ 25 % of peak syst. velocity
Δv *ΔT = λ / 2
5 m/sec
10cm/sec
Aliasing in pulsed wave DopplerAliasing in pulsed wave Doppler
Velocity waveform restoredby baseline shift or stacking
Tracking Spectrum algorithm Tracking Spectrum algorithm
Pulse no1 2 .. … N
Hans TorpNTNU, Norway
Pulse no1 2 .. … N
Conventional spectrum Tracking spectrum
Blood velocity spectrumBlood velocity spectrumSubclavian ArterySubclavian Artery
Conventional spectrum Tracking spectrum
-100
-50
50
100
PW DopplerPW DopplerTracking spectrumTracking spectrum
0.3m/s
2 m/s
5 m/s
.
Hans TorpNTNU, Norway
CW DopplerCW Doppler
Thermal noise
SNR considerations PW DopplerSNR considerations PW Doppler
Hans TorpNTNU, Norway
Doppler shift frequency [kHz]
Ult
raso
und
puls
e fr
eque
ncy
[MH
z]
Doppler shift frequency [kHz]
Pow
er
Pulsebandwidth B
Sample vol. size ~ pulse length ~1/ B
Thermal noise level ~ B (matched filter)
Blood signal spectral peak ~1/ B(blood vessel larger than sample vol.)
Spectral SNR ~ 1/ B^2
Double pulse length give + 6 dB SNR
What is the best pulse length?
Energy per pulse limited bythermal index or ISPTA
Summary spectral DopplerSummary spectral Doppler
• Complex demodulation give direction information of blood Complex demodulation give direction information of blood flowflow
• Smooth window function removes sidelobes from clutter-Smooth window function removes sidelobes from clutter-signalsignal
• PW Doppler suffers from aliasing in many cardiac PW Doppler suffers from aliasing in many cardiac applicationsapplications
• SNR increases by the square of pulse length in PW Doppler SNR increases by the square of pulse length in PW Doppler