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AIP Conference Proceedings 2062, 020049 (2019); https://doi.org/10.1063/1.5086596 2062, 020049

© 2019 Author(s).

Design and evaluation of pneumaticmicropump module for a portablepolymerase chain reaction kitCite as: AIP Conference Proceedings 2062, 020049 (2019); https://doi.org/10.1063/1.5086596Published Online: 25 January 2019

Yudan Whulanza, Taufik Ariesta Hakim, Muhammad S. Utomo, Shabrina Fadhilah, Jerome Charmet,Ridho Irwansyah, Warjito, and Gandjar Kiswanto

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1Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Indonesia 2Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Indonesia

Institute of Digital Healthcare, WMG, University of Warwick, United Kingdom

The 10th International Meeting of Advances in Thermofluids (IMAT 2018)AIP Conf. Proc. 2062, 020049-1–020049-8; https://doi.org/10.1063/1.5086596

Published by AIP Publishing. 978-0-7354-1790-8/$30.00

020049-1

Figure 1. Schematic of PCR-on-a-Chip with micropump to cyclical flow along the PCR path

Table 1. Operational parameter and overall dimension of PCR stages

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Figure 2. a) The cross section of the micropump module which a sandwich from top layer, mid layer and bottom layer; The pumping mechanics: b) A pneumatic force is introduced on the top layer; c) the elastic top layer moves down and deliver the

force downward; d) The cyclic force creates diaphragm movement in the bottom layer thus flow the liquid in the channel.

Figure 3.a) Micropump’s air channel where air infused in and out to create upward and downward movement; b) Micropump’s liquid channel where driven fluid is located

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Figure 4. a) Simulation in air channel to observe the displacement trough the membrane when a force is introduced and b) the simulation in the liquid channel to observe velocity distribution throughout the channel during pumping

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Figure 5. a) Realized module of micropump with coloured fluid inside the liquid channel; b) Breakdown of the micropump module into bottom layer (fluid channel) and top layer (air channel).

Table 2. The measurement of micropump geometry

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Figure 6. a) The observation of liquid from inlet to outlet point; b) The velocity profile along the traveled path from inlet tooutlet point

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Principles and Technical Aspects of PCR Amplification

AIP Conference Prosiding,

The Fluid Mechanics of Microdevices,

Analytical Chemistry

Journal of ISSS,

Micromachines,

Sensors and Actuators A: Physical,

Biomedical microdevices,

Microsystem Technologies,

Journal of Micromechanics and Microengineering,

Micromachines,

Sensors and Actuators A: Physical, Journal of Micromechanics and

Microengineering,

020049-8

https://doi.org/10.3390/mi6020216https://doi.org/10.1007/s00542-016-3029-6https://doi.org/10.1088/0960-1317/24/10/105010https://doi.org/10.1063/1.5023971https://doi.org/10.1063/1.5023973https://doi.org/10.1016/j.sna.2017.05.016https://doi.org/10.1007/s10544-006-9020-8https://doi.org/10.3390/mi9010001https://doi.org/10.1016/j.sna.2016.09.008