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Page 1: Makers of the world’s most advanced medical acrylics.€¦ ·  · 2018-01-31STERRAD Sterilization Page 10 ... which will decrease the cooling time and in turn ... slight color

Makers of the world’s most advanced medical acrylics.

Page 2: Makers of the world’s most advanced medical acrylics.€¦ ·  · 2018-01-31STERRAD Sterilization Page 10 ... which will decrease the cooling time and in turn ... slight color

Where do the most brilliant ideas come from? Some are born

within. Some are born from prior innovation. For decades,

CYRO’s acrylic-based compounds have been bringing brilliant

ideas into the realm of possibility for medical designers and

medical manufacturers everywhere.

CYRO’s line of medical polymers offers a superior balance of

properties and can be utilized in a variety of medical-oriented

applications. These include Medical Devices, Medical Packaging

and Medical Diagnostics. These compounds can be injection

molded, extruded and thermoformed. And, regardless of the

specific application, they consistently exhibit an unsurpassed

level of performance in processing, bondability, toughness,

chemical resistance, sterilization and optics.

Table of Contents

Medical Devices Pages 3-5

Medical Packaging Pages 6-8

Physiochemical and Drug Compatibility Properties for Pharmaceutical Contact Applications Page 9

STERRAD Sterilization Page 10

Medical Diagnostics Page 11

Environmental Page 11

Regulatory Page 11

You’ll find that some of the most brilliant ideas come

from CYRO’s acrylic-based multipolymer compounds.

2

Page 3: Makers of the world’s most advanced medical acrylics.€¦ ·  · 2018-01-31STERRAD Sterilization Page 10 ... which will decrease the cooling time and in turn ... slight color

CYRO offers the most advanced acrylic solutions for the

medical device industry. Products such as CYROLITE®

acrylic-based multipolymer compounds and CYREX®

acrylic-polycarbonate alloys are the true embodiment

of innovation. Both of these superior compounds exhibit

excellent characteristics for the most demanding and

diverse medical device applications.

Performance.This word, without a doubt, best describes

CYROLITE compounds.That’s because CYROLITE

compounds offer the very best balance of properties for

medical device applications. All grades of CYROLITE

compounds are engineered for applications where gamma

or e-beam sterilization is required, as they invariably

demonstrate no loss in properties. CYROLITE compounds

are easy to process and can be used for very intricate to

very large medical device parts. Every grade offers unique

characteristics and a variety of benefits. However, they are

all tough, transparent, bondable, gamma, e-beam and EtO

sterilizable, and chemically resistant. In other words, they

are just what you need.

Elongation retention after exposure to stress in presence of a chemical has been found to be a good measure of chemical resistance.

Initial Elongation @ break, %

Lipid ResistantPolycarbonate

140.0

CYROLITE Med 2Compound

14.8

IPA Exposure@ 2.0% Strain/5 hrs @ 23°CElongation @ break

% Retention of Elongation @ break

6.04.0

22.8154.0

Lipid Solution Exposure @ 2.0% Strain/24 hrs @ 23°CElongation @ break

% Retention of Elongation @ break

4.0

3.0

17.7

106.0

Chemical Resistance to Lipids and IPA

Chemical Resistance as a Function of StrainCYROLITE Med 2 Compound vs Lipid Resistant Polycarbonate

Elo

ngat

ion

Ret

enti

on,

%

0

50

100

150

200

CYROLITE Med 2 Lipid resistant PC

ISOPROPANOL (IPA) RESISTANCE @ 2.0% Strain/5 hrs @ 23°C

LIPID RESISTANCE @ 2.0% Strain/24 hrs @ 23°C

CYROLITE Med 2

Elo

ngat

ion

Ret

enti

on,

%

Lipid resistant PC

0

20

40

60

80

100

120

“ ”“CYROLITE Med 2 provided excellent processing and

consistent results in G Force expansion. Because the tube'sshape is so critical to process, the tube must consistentlyretain the exact mold shape without deviation. We foundthe CYROLITE compound easy to work with, and it consistently held the mold design without tapering.”

– Joel Higgins, Director of Resorbables Engineering, Biomet

“ ”“We chose CYROLITE CG-97 compound for the housing

because its chemical-resistant properties improve thedurability and functionality of the Medipure IV Filter.”

– John Leahey, Senior Program Manager, Filtertek

Breakthrough Chemical Resistance to Lipids and IPA Subjecting parts made with CYROLITE Med 2 compound to stress tests in the presence of lipid and alcohol solutionsdemonstrates unprecedented retention of performanceproperties by an acrylic-based material.

3

Page 4: Makers of the world’s most advanced medical acrylics.€¦ ·  · 2018-01-31STERRAD Sterilization Page 10 ... which will decrease the cooling time and in turn ... slight color

When it comes to Medical Device applications, CYREX

200-8005 acrylic-polycarbonate alloy will exceed all your

expectations — and then some.This advanced alloy is

formulated specifically for the medical industry and offers

a unique combination of properties that will enhance the

performance of medical devices that are particularly

opaque. CYREX 200-8005 alloy exhibits exceptional

toughness characteristics and is chemically resistant to

both alcohol and lipids. In addition, it is EtO, e-beam and

gamma sterilizable, and easy to process. In fact, it can

be processed at lower temperatures than straight polycar-

bonate, which will decrease the cooling time and in turn

decrease the cycle time of an injection molding process.

Vu-Stat™ static dissipative acrylic multipolymer compounds

are transparent, electro-static dissipative compounds

that have outstanding ESD properties and an excellent

balance of mechanical, thermal and flow properties.

Vu-Stat compounds provide permanent ESD protection

for parts that are sensitive to static discharge.

CYRO Industries offers two grades of Vu-Stat compounds

for medical device applications requiring a transparent,

tough, anti-static compound. Applications would include

those involving inhalation drug delivery where a static-free

mouthpiece and spacer mean more of the drug is delivered

to the patient. In bracheotherapy applications, a static-free

needle hub environment makes delivery of radioactive

materials to the patient much easier.Vu-Stat compounds are

inherently anti-static and do not depend on relative humidity

to deliver static-free results.The material retains permanent

static dissipative properties even after many washings.

The CYRO AdvantageBondability: CYRO’s medical polymers offer excellent and

consistent bonding to PVC tubing and other mating plastics

and are superior to ABS types of plastic. Parts can be

solvent or thermal-bonded and ultrasonic or spin-welded.

Typical bonding solvents are: cyclohexanone (excellent

for bonding vinyl), tetrahydrofuran, methyl methacrylate

monomer, methyl ethyl ketone and toluene. Cyanoacrylate

and UV curable adhesives are also recommended. It is

important to remember that all solvents should be evaluated

for suitability and applicability and should be handled only

by qualified persons familiar with their potential hazards.

Welding: CYRO’s medical polymers can be readily welded

using radio frequency, ultrasonic, vibration, spin or hot plate

welding. Radio frequency welding is the process of fusing

materials together by applying radio frequency energy.

Ultrasonic, vibration and spin welding methods utilize

friction to melt the materials at the weld interface.

Hot plate welding uses heating elements to transfer energy

that softens or diffuses the surfaces prior to pressing them

together. Ultrasonic welding is probably the most popular

method for welding thermoplastic materials.

Sterilization: CYRO’s medical polymers can be sterilized

by either ethylene oxide gas or radiation techniques.

CYROLITE GS-90 and CYROLITE CG-97 acrylic-

based multipolymer compounds make a permanent,

slight color change to a pleasing blue-green tint after

being radiated, which allows medical parts to be sent

to market immediately after irradiation.

CYROLITE G-20, CYROLITE G-20 HIFLO®, and

CYROLITE Med 2 acrylic-based multipolymer

compounds have an initial color change that returns

to near normal appearance after four to five weeks.

CYREX 200-8005 acrylic-polycarbonate alloy is a

medical grade white product that exhibits very little

change after gamma exposure.

Vu-Stat compounds experience an initial color change

after gamma or e-beam exposure.The change in color

returns to near normal appearance after four weeks.

EtO has little or no affect on the appearance.

All CYROLITE and XT compounds can be sterilized

using the STERRAD® Sterilization System. See page 10.

4

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Processability: CYRO’s medical polymers are easy to

injection mold and are readily adaptable to tooling designed

for styrene, vinyl, ABS and polycarbonate.The cycle time in

injection molding is excellent, and the regrind can be readily

used. All grades offer exceptional ease of processing.

However, CYROLITE G-20 HIFLO and CYROLITE GS-90

compounds are the most superior in this category. In addition,

CYROLITE Med 2 compound has excellent processability

at low temperatures, and its high flowability as measured by

spiral flow is perfect for extremely thin-walled applications

and complex multicavity molds.

Optics: Transparent CYRO medical polymers offer high

light transmission with little haze.They can be easily

pigmented or dyed to a wide variety of transparent and

opaque colors.

Chemical Resistance: All CYRO medical polymers offer

resistance to body fluids and many chemicals, especially

plasticizers. However, for superior chemical resistance,

including resistance to alcohol and lipids, CYROLITE

CG-97 and CYROLITE Med 2 compounds are in a class

of their own.

Toughness and Impact Resistance: CYRO’s medical

polymers offer a variety of products and grades that can

meet any number of toughness and impact resistance

needs. CYREX 200-8005 alloy offers the maximum

impact resistance, boasting a notched Izod impact of 15.7.

Typical medical device applications include:• Lures

• Spikes

• Fittings

• Nozzles

• Protection caps and covers

• Blood plasma separators

• Collection and specimen vessels

• Needle and tube collars or adapters

• Catheter accessories

• Chest drainage units

• Valve assemblies

• Meter housings

• Flow controls

• Filter housings

• Drip chambers

• IV adapters

• Yankauers

• Rigid tubes

• Bracheotherapy needle hubs

• Inhalation mouthpieces and spacers

At-A-Glance — Medical Devices

GRADE FLOW COMMENT

CYROLITE G-20 Intermediate More chemically resistant than CYROLITE G-20 HIFLO

CYROLITE G-20 HIFLO High Highest melt flow

CYROLITE GS-90 High Best appearance after gamma sterilization

CYROLITE CG-97 Intermediate Superior lipid resistance and very good alcohol resistance; highest impact

CYROLITE Med 2 Intermediate Superior alcohol and lipid resistance; best ductility

Vu-Stat High Inherently anti-static; excellent balance of mechanical, thermal and flow properties

CYREX 200-8005 Medium Maximum toughness and chemical resistance; opaque5

15

17

19

21

23

25

27

29

31

33

35

PCTG TABS Lipid ResistPC at 625°F

HIGHFLOW PCat 575°F

CYROLITEG-20

CYROLITECG-97

CYROLITEMed 2

CYROLITEG-20

HIFLO

VU-STAT CYROLITEGS-90

Inch

es

Spiral Flow (In) 0.125" Depth, Melt at 450ºF, Mold at 105ºF

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XT® polymer acrylic-based multipolymer compounds are

transparent, impact modified acrylic-based multipolymer

compounds that offer exceptional chemical resistance,

including resistance to plasticizers found in PVC and other

flexible plastics. XT polymer compounds offer good heat

distortion temperature, outstanding impact strength and

are all suitable for ethylene oxide sterilization. Moreover,

XT polymer compounds are resistant to body fluids and

have a high light transmission.

XT polymer compounds are designed to withstand the

toughest conditions in medical packaging. Best of all, they

consistently outperform PETG in both notched Izod impact

strength and tensile elongation testing after EtO sterilization.

XT polymer compounds consist of four different grades

varying in molecular weight and rubber loading.

Xtreme Performance• Superior EtO resistance over PETG

• Resistant to PVC plasticizers

• Resistant to gamma and e-beam sterilization

• Superior heat distortion temperatures

• Outstanding thermoformability

• Excellent rigidity

• Tamper-evident that will stress-whiten if punctured

• Can be down-gauged, resulting in improved cost

and source reduction

• Can be used with most lidding stock

and bonding techniques

• Outstanding transparency for easy inspection

• Easily stackable, eliminating silicone

migration concerns

• Reuse of regrind offers economic

and environmental benefits

• Incineration: No generation of supertoxins

makes for easy incinerationAt-A-Glance — Medical Packaging

GRADE FLOW COMMENT

XT polymer 250 Medium Desirable balance between processability and chemical resistance

XT polymer 375 Stiff Best chemical resistance of XT polymer compound grades

XT polymer 375TE Stiff Allows for easy seal inspection

XT polymer X800RG High Easiest to process; most clarity in thin gauge packaging

XT polymer compounds toughness characteristics are evident in its combination of Izod impact and elongation at break characteristics. Both these properties remain stableafter EtO exposure and over time as demonstrated in thetables and graphs on page 7. PETG's toughness characteristicsare related to its elongation at break property. After EtO sterilization, the elongation property of PETG is immediatelyreduced by half after which it continues to deteriorate as itages until it becomes fairly brittle.

6

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Heat Aging of XT Polymer Compounds for Medical PackagingStandard: ASTM D 3045 "Standard Practice for Heat Aging of Plastics Without Load" Conditions: Temperature = 50ºC EtO Sterilization: Standard Hospital Cycle

Tensile Elongation Tensile Flexural Flexural Izod Impact Deflection Strength1 @ break1 Modulus1 Strength2 Modulus2 Resistance3 Temperature4

psi % kpsi psi kpsi fppi @ 23ºC ºC

XT 375TEUnsterilized 8220 11 399 12700 370 2.05 78EtO Sterilized 8270 7 400 12800 365 2.07 80Accelerated Aging 3 weeks 8300 11 416 13250 358 2.03 856 weeks 8100 12 416 13050 378 2.08 8512 weeks 7970 10 390 12500 352 2.13 83

XT 375Unsterilized 8310 11 393 12740 357 2.03 80EtO Sterilized 8200 9 387 13300 401 2.03 80Accelerated Aging 3 weeks 8330 7 410 13400 388 2.00 846 weeks 7940 8 409 13380 374 2.04 8612 weeks 8100 11 388 12720 369 2.05 84

XT X800RG Unsterilized 7213 6 335 9300 353 2.21 80EtO Sterilized 7340 7 353 9600 307 2.25 81Accelerated Aging 3 weeks 7250 7 368 11220 330 2.20 866 weeks 7110 9 346 11500 318 2.29 8612 weeks 7140 8 343 11100 344 2.35 85

PETG 6763Unsterilized 7600 104 299 11200 272 0.55 70EtO Sterilized 8000 50 314 12100 268 0.54 73Accelerated Aging 3 weeks 8900 33 310 13050 280 0.51 796 weeks 9240 21 303 13350 290 0.55 8012 weeks 9700 5 328 13210 288 0.54 79

1ASTM D 638 Heat Aging correlation* to real-time (storage @ 22ºC): * Aging Rate = Q10 2ASTM D 790 3 weeks = 145 days Q10 = 2.0 Aging Rate = 6.96 3ASTM D 256; 1/4" [6.35 mm] bar 6 weeks = 290 days Heat Aging = Real Time Aging/Aging Rate 4ASTM D 648; @ 264 psi, annealed 12 weeks = 580 days Heat Aging = Real Time Aging/6.96

Heat Aging – Notched IzodASTM D 3045 "Standard Practice for Heat Aging of Plastics Without Load"

Exposure Conditions: 50ºCEthylene Oxide Sterilization: Standard Hospital Cycle

ASTM D 256; Noched Izod @ 23ºC

0

1

2

3

4

5

Initial EtO Sterilized 3 weeks 6 weeks 12 weeks

Heat Aging Exposure Time

No

tche

d Iz

od

, fp

pi

XT 375TE XT 375 XT X800RG PETG 6763

Unsterilized

Heat Aging – Tensile ElongationASTM D 3045 "Standard Practice for Heat Aging of Plastics Without Load"

Exposure Conditions: 50ºCEthylene Oxide Sterilization: Standard Hospital Cycle

ASTM D 638; Elongation @ Break

0

10

20

30

40

50

60

70

80

90

100

110

120

Initial EtO Sterilized 3 weeks 6 weeks 12 weeks

Heat Aging Exposure Time

Tens

ile E

long

atio

n @

Bre

ak, %

XT 375TE XT 375 XT X800RG PETG 6763

Unsterilized

((Elevated temp. - Ambient)/10)

7

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All grades of XT polymer compoundsexcel in the medical packaging industry.

PETG 6763

XT polymer 375TE

F = FlangeW = Side wallC = CornerBC = Bottom next to cornerB = Mid bottom

Wall Thickness Distribution Typical vacuum forming conditions XT polymer vs PETG 6763

Areal Draw Ratio: 1.8:1Sheet Thickness ~ 25 mils

110

100

90

80

70

60

50F W C BC B

Measurement Location

Thermoforming Characterization

B BC C W F

Wal

l Thi

ckne

ss, %

100100

78

67

81

99

70

63

71

92

-5

-2.5

0

2.5

5

Initial Day5

Day7

Day9

Day12

Day15

Day20

Day25

Day30

17 mils

Yel

low

nes

s In

dex

25 mils 40 mils

on Yellowness Index with Respect to Film Thickness

XT Polymer 375TE — Effect of Gamma Irradiation (25 kGys)

-5

-2.5

0

2.5

5

Initial Day5

Day7

Day10

Day14

Day20

Day25

Day30

17 mils

Yel

low

nes

s In

dex

25 mils 40 mils

on Yellowness Index with Respect to Film Thickness

XT Polymer 375TE — Effect of EtO Sterilization

XT polymer compounds made into thin gauge sheet for medical packaging trays canbe sterilized either by gamma or EtO with little loss of properties or appearance.

8

XT polymer compounds excel in thermo-forming because they resist shear thinning more than many other thermo-plastic materials such as PETG. Shear thinning resistance allows thermoformedparts to have better wall thickness distribution as well as stronger walls and corners.

The graph provides an overview of the material distribution of both XT polymer 375TE compound and PETG in a thermoformed part. The original sheetthickness of both materials starts at 25mils. Both sheets are thermoformed in the same tool with an areal draw ratio of1.8:1. At point W (wall), XT polymer 375TEcompound retains 78% of its originalthickness and PETG 70%. At point C

(corner), XT polymer 375TE compoundretains 67% of its original thickness and PETG 63%. At point B (bottom), XTpolymer 375TE compound retains 99%and PETG only 92%.

Astute Packaging Engineers will recognizesignificant cost savings by choosing packaging trays made from XT polymercompounds — even if sheet made fromXT polymer compounds cost more on aper pound basis than PETG. XT polymer compounds offer a 13% specific gravitysavings over PETG and, because they are significantly more rigid, they offer valuabledown-gauging possibilities. (The betterdistribution of material during thermo-forming also allows for further down-gauging potential).

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Physiochemical and Drug CompatibilityProperties for Pharmaceutical ContactApplications – CYROLITE, XT polymer and CYREX You’ll be happy to know that CYROLITE and

XT polymer compounds and CYREX alloys are

contact compatible with a variety of pharmaceutical

treatment drugs and carriers. Moreover, these

compounds also pass requirements for United

States Pharmacopoeia 26, National Formulary

21, 2003 <661> “Physiochemical Tests –

Plastics” – Containers, for containers intended

for pharmaceutical treatment drugs and solutions.

For further information on these test results, you

can contact your CYRO Representative.

CYROLITE and XT polymer compounds and

CYREX alloys have been tested for compatibility

with human insulin solution,Taxol®*, Heparin,

protein solution and common drug treatment

carrier solutions.

LIPID RESISTANCEAt 1.2% Strain/24 hrs @ 30°C At 0.9% Strain/3 hrs @ 20°C At 0.9% Strain/5 hrs @ 20°C

TENSILE STRENGTH ELONGATION AT BREAK TENSILE STRENGTH ELONGATION AT BREAK

60

80

100

120

20

0

40

ISOPROPANOL ALCOHOL RESISTANCE ISOPROPANOL ALCOHOL RESISTANCE

Pro

pe

rty

Re

ten

tio

n,

%

TENSILE STRENGTH ELONGATION AT BREAK

XT polymer 375 XT polymer 250 CYROLITE G-20 CYROLITE GS-90 CYROLITE CG-97 CYROLITE Med 2

CYRO ACRYLIC POLYMERS PRODUCT KEY

Chemical Resistance At-A-Glance

9

It’s important to note that a CYRO product’s applicability in a given end-use environmentis dependent on a number of conditions including, without limitation, chemical compatibility,temperature, part design, sterilization method, residual stresses and external loads. It is the responsibility of the manufacturer to evaluate its final product under actual end-userequirements and to adequately advise and warn purchasers and users thereof.

*Taxol® is a registered trademark of Bristol-Myers Squibb Company.

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STERRAD Sterilization – CYROLITE and XT polymerCYROLITE and XT polymer compounds can be

sterilized using the STERRAD®* Sterilization System.

The Johnson & Johnson STERRAD System utilizes

a combination of hydrogen peroxide vapor and

low-temperature gas plasma to rapidly sterilize most

medical instruments and materials without leaving

any toxic residues.Tests show that CYROLITE and

XT polymer compounds tensile strength and elongation

properties are not adversely affected by STERRAD

sterilization.This sterilization process does affect the

haze of XT polymer and CYROLITE compound products.

XT 250 XT 375 G-20 HIFLO GS-90 CG-97

0

5

10

15

20

Tens

ile E

long

atio

n at

Bre

ak, %

STERRAD Sterilization Effectson XT Polymer and CYROLITE Compounds

Elongation at break, % Elongation at break, % – Sterilized

XT 250 XT 375 G-20 HIFLO GS-90 CG-97

2,000

0

4,000

6,000

8,000

10,000

STERRAD Effects on Tensile Strengthof XT Polymer and CYROLITE Compounds

Tensile Strength, psi Tensile Strength – Sterilized, psi

Tens

ile S

tren

gth

, psi

XT 250 XT 375 G-20 HIFLO GS-90 CG-97

0

5

10

15

20

25

Haz

e, %

STERRAD Sterilization Effects on Hazeof XT Polymer and CYROLITE Compounds

Haze, % Haze, % – Sterilized

10

*STERRAD® is a registered trademark of Johnson & Johnson.

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ACRYLITE acrylic polymers are ideal for medical

diagnostic applications because they offer optical clarity

or maximum visible and ultraviolet light transmitting

characteristics.They are also easy to process and exhibit

good dimensional stability.

ACRYLITE polymers are available in a number of grades

and have excellent optical properties, which make them

ideal for many uses.They are completely transparent and

are essentially colorless.

In making optical diagnostic components, the purity of the

polymers is paramount.When manufacturing ACRYLITE

polymers, a great deal of attention is given to ultraviolet

visible light transparency and cleanliness. In fact,

ACRYLITE polymers are subject to the strictest standards

in production quality control.

ACRYLITE polymers are used extensively in medical

diagnostic applications:

• Diagnostic cuvettes

• Diagnostic test packs

• Diagnostic rotors

CYRO’s products comply with the following Tripartite, ISO 10993-1, USP and FDA regulations.

Regulatory RequirementsGrade Food Contact*1 USP Class VI*2 Tripartite*3

XT polymer 250 compound Yes Yes*4 Yes*6

XT polymer 375 compound Yes Yes*4 Yes*6

XT polymer 375TE compound Yes Pending Not Tested

XT polymer X800RG compound Yes Yes Not Tested

CYROLITE G-20 compound Yes Yes*5 Yes*5

CYROLITE G-20 HIFLO compound Yes Yes*5 Yes*5

CYROLITE CG-97 compound Yes Yes*5 Yes*5

CYROLITE GS-90 compound Yes Yes*5 Yes*5

CYROLITE Med 2 compound Not Tested Yes*5 Yes*5

CYREX 200-8005 alloy Yes Yes*7 Yes*7

Vu-Stat C-37 compound Not Tested Not Tested Not Tested

Vu-Stat Y-20 compound Not Tested Yes*5 Yes*5

ACRYLITE polymers Yes Yes*8 Yes*8

*1 Products meet the requirements in

21CFR177.1010, 21CFR180.22, and

21CFR177.1580 as appropriate to the

specific product.

*2 Class VI United States Pharmacopoeia tests for

determining the suitability of a plastic material

intended for use in fabricating containers or

accessories thereto, for parenteral preparations.

*3 Indicated products have been found to be

non-hemolytic, non-cytotoxic, non-pyrogenic,

non-sensitizing and non-mutagenic when

tested following the Tripartite and

ISO 10993-1 Protocols.

*4 In natural and 301 tints only;

not tested in other colors.

*5 In 001 tint only; not tested in other colors.

*6 In 301 tint only; not tested in other colors.

*7 In 8005 color only.

*8 ACRYLITE H-10 polymers not tested.

Source Reduction and Incineration: XT polymer and

CYROLITE compounds can be recycled, reprocessed and are

compatible with many other polymers such as polystyrene.

XT polymer and CYROLITE compounds, as well as

ACRYLITE polymers, can be safely incinerated and

are safe to landfill. Reducing the amount of material that

enters the waste system is the preferred method of making

waste more manageable. Some source reduction techniques

include: elimination of parts/packing; thin walling/material

efficiency; use of concentrates; refills; reduction in toxicity;

increase in life expectancy and elimination of planned

obsolescence. CYRO molding compounds lend themselves

to many of these techniques.

11

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All CYRO manufacturing facilities are ISO 9001:2000 Certified.CYRO plants are located in Wallingford, CT; Westwego, LA;Sanford, ME and Osceola, AR. Attaining ISO registration at allfour CYRO facilities insures CYRO will continue to improve itsprocess, products and service performance.

HEADQUARTERS:CYRO Industries100 Enterprise DriveRockaway, NJ 07866973-442-6000800-631-5384

SALES OFFICES:US & CanadaXT polymers & CYROLITE compounds100 Enterprise DriveRockaway, NJ 07866973-442-6000

ACRYLITE polymers25055 West Valley ParkwaySuite 129Olathe, KS 66061913-254-9404

South/Latin America100 Enterprise DriveRockaway, NJ 07866973-442-6086

Europe, Africa & The Asia Pacific RegionDegussa AGKirschenallee64293 DarmstadtGermany49-6151-184334

CUSTOMER SERVICE:United States & Canada800-225-0172

South/Latin America973-442-6086

Europe, Africa & The Asia Pacific Region49-6151-184775

TECHNICAL SUPPORT:Visit the TechKnowlogy Center at www.cyro.comwhere visitors have immediate access to FAQ,technical information, tips, and hundreds of otherfacts about acrylic-based polymers.

www.cyrolite.com

$9.951856B-0105-5RJ©2005 CYRO Industries. All rights reserved.