MACIE

11 yo Golden RetrieverAccession: 102165

Macie Previous hx: bilateral CCL rupture repair,

surgically excised MCT, no further tx July 2008-presented to RDVM for increased

stiffness and difficulty rising August Orthopedic Sx appt-

Difficulty rising Smoothly irregular boney proliferation along

medial wall of pelvis no hip pain L hip easily subluxates and reduces readily with

manipulation

Macie’s Radiographs

7/18

4/1

8/119/29

8/12-CT findings• Extensive, mildly irregular periosteal

reaction and hyperostosis• Non-displaced acetabular fracture• Widening of the joint space by fluid

attenuating material • Expansion of joint capsule with contrast

enhancing rim• The lack of a soft tissue component

made neoplasia unlikely• Acetabular fx with pelvic

hyperostosis; chronic infection cannot be ruled out

Macie Managed medically for 5 wks, became

slightly worse according to owner CT and radiographs repeated on 9/29

Acetabular fracture line mildly less apparent Hyperostosis similar if not mildly smoother No osseous destruction noted

FHO and acetabular and joint capsule biopsies

HXPX: Joint capsule: diffuse, moderate fibrosis Acetabulum: CHONDROSARCOMA with

invasion into the bone marrow

Chondrosarcoma Neoplastic chondrocytes that produce chondroid matrix Second most common primary bone tumor, <10% of

primary bone tumors in dogs Primarily large breed dogs Locations:

30% of chondrosarcomas are nasal In 31 non-nasal chondrosarcomas (Waltman, et al, 2007):

Ribs (12) Long bones (13) Maxilla/Mandible (5) Scapula (1)

Metastatic rate historically related to site: Rib& long bone-57% Facial bone-40%

Non-nasal Chondrosarcoma

Clinical Outcomes (Waltman, et al, 2007) Treated with wide surgical excision Metastatic sites: lung, liver, kidney, lymph nodes,

adrenal gland, bone Metastatic rate NOT statistically altered by

treatment: 15 (treated)-28(untreated)% Survival better with rib and limb chondrosarcoma,

possibly b/c determined resectability Survival times

Mean (treated)=3097 d; Median (treated)=not reached Mean (untreated)=523 d; Mediatn (untreated)=495 d

Histologic grade was prognostic

Coccygeal Vertebral Chondrosarcoma

• 6 yo St. Bernard• Tail-base mass over 3 months duration• Cortical destruction, mottled mineralized

densities, ill-defined margins, and continuous but relatively slow growth

• HxPx: Chondrosarcoma• Chondrosarcomas are predominantly

osteolytic?

What Is Your Diagnosis?• 10 yo Labrador• Unwilling to climb stairs 4

wks• Neck pain, resistant to

dorsoflexion• Radiographs: Focal

lucency in the dorsal lamina of C2

• MRI: Extradural mass at the level of C2

• Surgery: Thinning of lamina of C2, with extradural mass ventral and to right of dog

• HxPx: Chondrosarcoma• Recurrence of C/S: within

2 months with subsequent euthanasia

What Is Your Diagnosis?• 7 yo Boxer• 4 wk history lameness• Non-specific stifle

lameness• Multi-loculated lytic bone

lesion of distal femoral metaphysis

• Medial soft tissue mineralization

• “Differential diagnoses include a primarybone tumor, such as osteosarcoma, chondrosarcoma, fibrosarcoma, hemangiosarcoma, liposarcoma, giant cell tumor,

or plasma cell tumor; multiple myeloma; bacterial or fungalosteomyelitis; or a bone cyst. “

References Waltman SS, et al. Clinical Outcome of Nonnasal

Chondrosarcoma in Dogs: 31 Cases (1986-2003). Veterinary Surgery, Vol 36, 2007. pp 266-271.

Hamersalg KL, et al. Coccygeal Vertebral Chondrosarcoma in a Saint Bernard: A Case Report. Vet Rad & US, Vol. 21, No.5, 1980: pp 194-196.

Mazur WJ, et al. What Is Your Diagnosis? JAVMA, Vol 226, No. 8, 2008; pp 1301-1302.

Haper TA, et. Al. What Is Your Diagnosis? JAVMA, Vol 232, No. 5, 2008; pp 681-682.