m 2 presentation(final)

Microcalcification identificationin digital mammogram for earlydetection of breast cancerMasters -2 Presentation

Nashid AlamRegistration No: [email protected]

Supervisor: Prof. Dr. M. Shahidur Rahman

Department of Computer Science And Engineering

Shahjalal University of Science and TechnologyWednesday, April 15, 2015

Driving research for better breast cancer treatment “The best protection is early detection”

Introduction

Breast cancer:The most devastating and deadly diseases for women.

o Computer aided detection (CADe) o Computer aided diagnosis (CADx) systems

Computerize Breast cancer Detection System:

Steps to control breast cancer:1) Prevention2) Detection3) Diagnosis4) Treatment

We will emphasis on :1) Detection2) Diagnosis

Background Interest

Ultrasound/ Sonogram MRI

Background Interest

Interest comes from two primary backgrounds

Improvement of pictorial information for humanperception

How can an image/video be made more aesthetically pleasingHow can an image/video be enhanced to facilitateextraction of useful information

Processing of data for autonomous machineperception- Machine Vision

Mam

mo

gram(2

D)

Tom

ogram

(3D

)

Micro-calcification

Mammography

Mammogram

Background knowledge

Micro-calcification


Micro-calcification

Micro-calcifications :- Tiny deposits of calcium- May be benign or malignant- A first cue of cancer.

Position:1. Can be scattered throughout the mammary gland, or 2. Occur in clusters.(diameters from some µm up to approximately 200 µm.)3. Considered regions of high frequency.

Micro-calcification

They are caused by a number of reasons:

1. Aging –The majority of diagnoses are made in women over 50

2. Genetic –Involving the BRCA1 (breast cancer 1, early onset) and

BRCA2 (breast cancer 2, early onset) genes

Micro-calcifications Pattern Determines :The future course of the action-

I. Whether it be further investigatory techniques (as part of the triple assessment), or

II. More regular screening

Mammography


Mammography Machine

Mammography

USE:I. Viewing x-ray imageII. Manipulate X-ray image on a computer screen

Mammography :

Process of using low-energyx-rays to examine the human breast

Used as a diagnostic and a screening tool.

The goal of mammography :The early detection of breast cancer

Mammography Machine

Mammogram


mdb226.jpg

Mammogram

Mammogram:An x-ray picture of the breast

Use:To look for changes that are not normal.

Result Archive:The results are recorded:

1. On x-ray film or 2.Directly into a computer

mdb226.jpg

LITERATURE REVIEW

Wang et.al.(1989):The mammograms are:

-Decomposed into different frequency subbands.

The low-frequency subband discarded.

Literature Review

Literature Review

Daubechies I.(1992): Wavelets are mainly used :

-Because of their dilation and translation properties-Suitable for non stationary signals.

Strickland et.at (1996) :

Used biorthogonal filter bank-To compute four dyadic and -Two cinterpolation scales.

Applied binary threshold-operator -In six scales.

Literature Review

Heinlein et.al(2003):Goal: Enhancement of mammograms:

Derived The integrated wavelets:- From a model of microcalcifications

Literature Review

Zhibo et.al.(2007):A method aimed at minimizing image noise.

Optimize contrast of mammographic image featuresEmphasize mammographic features:

A nonlinear mapping function is applied:-To the set of coefficient from each level.

Use Contourlets:For more accurate detection of microcalcification clusters

The transformed image is denoised-using stein's thresholding [18].

The results presented correspond to the enhancement of regions with large masses only.

Literature Review

Fatemeh et.al.(2007) :

Focus on:

-Analysis of large masses instead of microcalcifications.

- Detect /Classify mammograms:

Normal and Abnormal

Use Contourlets Transform:

For automatic mass classification

Literature Review

Balakumaran et.al.(2010) :

Focus on:

- Microcalcification Detection

Use :

- Wavelet Transform and Fuzzy Shell Clustering

Literature Review

Literature Review

Zhang et.al.(2013) :

Use Hybrid Image Filtering Method:

- Morphological image processing- Wavelet transform technique

Focus on:

- Presence of microcalcification clusters

Literature Review

Lu et.al.(2013) :

Use Hybrid Image Filtering Method:

- Multiscale regularized reconstruction

Focus on:

- Detecting subtle mass lesions in Digital breast tomosynthesis (DBT)

- Noise regularization in DBT reconstruction

Literature Review

Leeuw et.al.(2014) :

Use:

- Phase derivative to detect microcalcifications - A template matching algorithm was designed

Focus on:

- Detect microcalcifications in breast specimens using MRI

- Noise regularization in image reconstruction

Literature Review

Shankla et.al.(2014) :

Automatic insertion of simulated microcalcification clusters-in a software breast phantom

Focus on:

-Algorithm developed as part of a virtual clinical trial (VCT) :-Includes the simulation of breast anatomy, - Mechanical compression- Image acquisition- Image processing, displaying and interpretation.

Problem Statement

Reason behind the problem( In real life):Burdensome Task Of Radiologist :

Eye fatigue:-Huge volume of images-Detection accuracy rate tends to decrease

Non-systematic search patterns of humansPerformance gap between :

Specialized breast imagers andgeneral radiologists

Interpretational Errors:Similar characteristics:

Abnormal and normal microcalcification

Problem Statement

The signs of breast cancer are:

Masses CalcificationsTumorLesionLump

Individual Research Areas

Problem Statement

Motivation to the Research

Motivation to the Research: Goal

Better Cancer Survival Rates(Facilitate Early Detection ).

Provide “second opinion” : Computerized decisionsupport systems

Fast,Reliable, andCost-effective

QUICKLY AND ACCURATELY :Overcome the development of breast cancer

Challenges

Develop a logistic model:

Early detection of Breast Cancer.

-Micro-calcification Enhancement

-To determine the likelihood of CANCEROUS AREA from the image values of mammograms.

Challenge:Occur in clusters

The clusters may vary in size from 0.05mm to 1mm in diameter.

Variation in signal intensity and contrast.May located in dense tissue

Difficult to detect.

Challenges

Plan of Action

Gantt Chart

Chart 01: Gantt Chart of this M.Sc thesis showing the duration of task against the progression of time

Schematic representation of the system

Sch

ema

tic

rep

rese

nta

tio

n

of

the

syst

em

Materials and Tools

Matlab 2001a

Database: MIAS

Database: MIAS databasehttp://skye.icr.ac.uk/miasdb/miasdb.html

Class Of Abnormality

Severity Of Abnormality

The Location Of The

Center Of The

Abnormality And Its

Diameter.

1 Calcification(25)

1.Benign(Calc-12)

2 Circumscribed Masses

3 Speculated Masses

4 Ill-defined Masses

5 Architectural Distortion

2.Malignant(Cancerous)

(Calc-13)

6 Asymmetry

7Normal

mdb223.jpg mdb226.jpg

mdb239.jpg mdb249.jpg

Figure01:X-ray image form MIAS database

Database: MIAS Databasehttp://skye.icr.ac.uk/miasdb/miasdb.html

Mammography Image Analysis Society (MIAS) -An organization of UK research groups

• Consists of 322 images-- Contains left and right breast images for 161 patients

• Every image is 1024 X 1024 pixels in size

• Represents each pixel with an 8-bit word

MIAS Database

Mammography Image Analysis Society (MIAS) -An organization of UK research groups

Database: http://skye.icr.ac.uk/miasdb/miasdb.html

http://see.xidian.edu.cn/vipsl/database_Mammo.html

Internal Breast Structure

MAIN NOVELTY

Input image

Bandpass

Directional

subbands

Bandpass

Directional

subbands

Main Novelty

-Contourlet Transform

- Specific Edge Filter (Prewitt Filter):To enhance the directional structures of the image in

the contourlet domain.

- Recover an approximation of the mammogram (with the microcalcifications enhanced):

Inverse contourlet transform is applied

Details in upcoming slides

Based on the classical approach used in transform methods for image processing.

1. Input mammogram

2. Forward CT

3. Subband Processing

4. Inverse CT

5. Enhanced Mammogram

Schematic representation of the system

Contourlet transformation

Implementation Based On :

• A Laplacian Pyramid decomposition followed by -

• Directional filter banks applied on each band pass sub-band.

The Result Extracts:-Geometric information of images.


Main Novelty

Enhancement of the Directional Subbands

The Contourlet Transform

Laplacian Pyramid: 3 level Decomposition

Frequency partitioning of a directional filter bank

Decomposition level l=3

The real wedge-shape frequency band is 23=8.

horizontal directions are corresponded by sub-bands 0-3

Vertical directions are represented by sub-bands 4-7





Laplacian Pyramid Level-1



8 Direction

4 Direction

4 Direction

(mdb252.jpg)




Wedge-shape frequency band is 23=8.

Horizontal directions are corresponded by sub-bands 0-3

(1) sub-band 0

(2) sub-band 1

(3) sub-band 2

(4) sub-band 3

Contourlet coefficient at level 4




Contourlet coefficient at level 4

Wedge-shape frequency band is 23=8.


(5) sub-band 4

(6) sub-band 5

(7) sub-band 6

(8) sub-band 7




(a) Main Image(mdb252.jpg)

(b) Enhanced Image(Average in all 8 direction)

(a) Main image(Toy Image)

Contourlet Transform Example

(b) Horizontal Direction

(c) Vertical Direction

Directional filter banks: Horizontal and Vertical

Contourlet Transform ExampleDirectional filter banks

Horizontal directions are corresponded by sub-bands 0-3

(1) sub-band 0

(2) sub-band 1

(3) sub-band 2

(4) sub-band 3

Contourlet Transform ExampleDirectional filter banks


(5) sub-band 4

(6) sub-band 5

(7) sub-band 6

(8) sub-band 7

Why Contourlet?

Why Contourlet?

•Decompose the mammographic image:

-Into directional components:

To easily capture the geometry of the image features.


Target


• This decomposition offers:

-Multiscale localization(Laplacian Pyramid) and -A high degree of directionality and anisotropy.

Why Contourlet? Usefulness of Contourlet

Directionality:Having basis elements Defined in variety of directions

Anistrophy:Basis Elements having Different aspect ration

Contourlet Transform Concept

(a)Wavelet(Require a lot of dot for fine resolution)

(b)Contourlet(Requires few different elongated shapes

in a variety of direction following the counter)

3 Different Size of Square Shape brush stroke(Smallest, Medium, Largest) to provide Multiresolution Image

Example: Painter Scenario

Why Contourlet?

2-D Contourlet Transform (2D-CT) Discrete WT

Handles singularities such as edges in a more powerful way

Has basis functions at many orientations has basis functions at three orientations

Basis functions appear a several aspectratios

the aspect ratio of DWT is 1

CT similar as DWT can beimplemented using iterative filter banks.

Advantage of using 2D-CT over DWT:


Input image

Bandpass

Directional

subbands

Bandpass

Directional

subbands

Plan-of-Action

For microcalcifications enhancement :

We use-The Contourlet Transform(CT) [12]

The Prewitt Filter.

12. Da Cunha A. L., Zhou J. and Do M. N,: The Nonsubsampled Contourlet Transform: Theory, Design, and

Applications, IEEE Transactions on Image Processing,vol. 15, (2006) pp. 3089-3101

Art-of-Action

An edge Prewitt

filter to enhance the

directional structures

in the image.

Contourlet transform allows

decomposing the image in

multidirectional

and multiscale subbands[6].

6. Laine A.F., Schuler S., Fan J., Huda W.: Mammographic feature enhancement by multiscale

analysis, IEEE Transactions on Medical Imaging, 1994, vol. 13, no. 4,(1994) pp. 7250-7260

This allows finding • A better set of edges,• Recovering an enhanced mammogram with better visual characteristics.

Microcalcifications have a very small size a denoising stage is not implemented

in order to preserve the integrity of the injuries.

Decompose the

digital mammogram

Using

Contourlet transform

(b) Enhanced image(mdb238.jpg)

(a) Original image (mdb238.jpg)

Method

CT is implemented in two stages:

1. Subband decomposition stage

2. Directional decomposition stages.


Method


For the subband decomposition:- The Laplacian pyramid is used [13]

Decomposition at each step:-Generates a sampled low pass version of the original-The difference between :

The original image and the prediction.

13. Park S.-I., Smith M. J. T., and Mersereau R. M.: A new directional Filter bank for image analysis and classification,Proceedings of IEEE International Conference on Acoustics, Speech, and Signal Processing (ICASSP '99), vol. 3, (1999) pp.1417-1420

Details ……..

Method


Details ……..

1. The input image is first low pass filtered

2. Filtered image is then decimated to get a coarse(rough) approximation.

3. The resulting image is interpolated and passed through Synthesis

filter.

4. The obtained image is subtracted from the original image :

To get a bandpass image.

5. The process is then iterated on the coarser version (high resolution)of the image.

Plan of Action

Method

2.Directional Filter Bank (DFB)

Details ……..

Implemented by using an L-level binary tree decomposition :

resulting in 2L subbands

The desired frequency partitioning is obtained by :

Following a tree expanding rule

- For finer directional subbands [13].

13. Park S.-I., Smith M. J. T., and Mersereau R. M.: A new directional Filter bank for image analysis and classification,Proceedings of IEEE International Conference on Acoustics, Speech, and Signal Processing (ICASSP '99), vol. 3, (1999) pp.1417-1420


The CT is implemented by:Laplacian pyramid followed by directional filter banks (Fig-01)

Input image

Bandpass

Directional

subbands

Bandpass

Directional

subbands

Figure 01: Structure of the Laplacian pyramid together with the directional filter bank

The concept of wavelet:University of Heidelburg

The CASCADE STRUCTURE allows:- The multiscale and

directional decomposition to be independent

- Makes possible to:Decompose each scale into

any arbitrary power of two's number of directions(4,8,16…)

Figure 01

Details ………….

Decomposes The Image Into Several Directional Subbands And Multiple Scales

Figure 02: (a)Structure of the Laplacian pyramid together with the directional filter bank(b) frequency partitioning by the contourlet transform(c) Decomposition levels and directions.

(a) (b)

Input

image

Bandpass

Directional

subbands

Bandpass

Directional

subbands

Details….

(c)

DenoteEach subband by yi,j

Wherei =decomposition level and J=direction


Decomposes The Image Into Several Directional Subbands And Multiple Scales

The processing of an image consists on:-Applying a function to enhance the regions of

interest.

In multiscale analysis:

Calculating function f for each subband :

-To emphasize the features of interest

-In order to get a new set y' of enhanced subbands:

Each of the resulting enhanced subbands can be

expressed using equation 1.

)(', , jiyfjiy ………………..(1)

-After the enhanced subbands are obtained, the inverse

transform is performed to obtain an enhanced image.



Denote

Each subband by yi,jWherei =decomposition level and J=direction Details….



Details….

The directional subbands are enhanced using equation 2.

)( , jiyf)2,1(

,1 nnWjiy

)2,1(,2 nnWjiy

If bi,j(n1,n2)=0

If bi,j(n1,n2)=1………..(2)

Denote

Each subband by yi,jWherei =decomposition level and J=direction

W1= weight factors for detecting the surrounding tissueW2= weight factors for detecting microcalcifications

(n1,n2) are the spatial coordinates.

bi;j = a binary image containing the edges of the subband

Weight and threshold selection techniques are presented on upcoming slides



The directional subbands are enhanced using equation 2.

)( , jiyf)2,1(

,1 nnWjiy

)2,1(,2 nnWjiy

If bi,j(n1,n2)=0

If bi,j(n1,n2)=1………..(2)

Binary edge image bi,j is obtained :-by applying an operator (prewitt edge detector)

-to detect edges on each directional subband.

In order to obtain a binary image:A threshold Ti,j for each subband is calculated.

Details….

Weight and threshold selection techniques are presented on upcoming slides

Threshold Selection


Details….

The microcalcifications appear :

On each subband Over a very

homogeneous background.

Most of the transform coefficients:

-The coefficients corresponding to theinjuries are far from background value.

A conservative threshold of 3σi;j is selected:where σi;j is the standard deviation of the corresponding subband y I,j .

Weight Selection


Exhaustive tests:-Consist on evaluating subjectively a set of 322 different mammograms

-With Different combinations of values,

The weights W1, and W2 are determined:-Selected as W1 = 3 σi;j and W2 = 4 σi;j

These weights are chosen to:keep the relationship W1 < W2:

-Because the W factor is a gain -More gain at the edges are wanted.

Experimental Results

Applying Contourlet Transformation Benign

Original image Enhanced image

Goal: Microcalcification Enhancement

mdb222.jpg

mdb223.jpg


mdb248.jpg

mdb252.jpg



mdb226.jpg

mdb227.jpg


mdb236.jpg

mdb240.jpg



Original image Enhanced image Original image Enhanced image

mdb218.jpgmdb219.jpg


Applying Contourlet Transformation MalignantGoal: Microcalcification Enhancement


mdb209.jpg

mdb211.jpg


mdb213.jpg

mdb231.jpg



mdb238.jpg

mdb239.jpg


mdb241.jpg

mdb249.jpg


mdb253.jpg



mdb256.jpg

Applying Contourlet Transformation NormalGoal: Microcalcification Enhancement


mdb003.jpg

mdb004.jpg


mdb006.jpg

mdb007.jpg



mdb009.jpg

mdb018.jpg


mdb027.jpg

mdb033.jpg



mdb046.jpg

mdb056.jpg


mdb060.jpg

mdb066.jpg



mdb070.jpg

mdb073.jpg


mdb074.jpg

mdb076.jpg



mdb093.jpg

mdb096.jpg


mdb101.jpg

mdb012.jpg



mdb128.jpg

mdb137.jpg


mdb146.jpg

mdb154.jpg



mdb166.jpg

mdb169.jpg


mdb224.jpg

mdb225.jpg



mdb263.jpg

mdb294.jpg


mdb316.jpg

mdb320.jpg

Wavelet Transformation

Use Separable Transform

2D Wavelet Transform

Visualization

Label ofapproximation

HorizontalDetails

HorizontalDetails

VerticalDetails

DiagonalDetails

VerticalDetails

DiagonalDetails



Decomposition at Label 4

Original image(with diagonal details areas indicated)

Diagonal Details



Vertical Details

Decomposition at Label 4

Original image(with Vertical details areas indicated)


DWT

1.Original Image(Malignent_mdb238) 2.Decomposition at Label 4

2.Decomposition at Label 1 3.Decomposition at Label 2 3.Decomposition at Label 3


DWT

1.Original Image(Malignent_mdb238) 2.Decomposition at Label 4


1.Original Image(Benign_mdb252)

2.Decomposition at Label 4


DWT


1.Original Image(Malignent_mdb253.jpg) 2.Decomposition at Label 4


Metrics: Quantitive Measurement

Metrics

To compare the ability of :

Enhancement achieved by the proposed method.

Why?

1. Measurement of distributed separation (MDS)

2. Contrast enhancement of background against target (CEBT) and

3. Entropy-based contrast enhancement of background against target (ECEBT) [14].

Measures used to compare:

14. Sameer S. and Keit B.: An Evaluation on Contrast Enhancement Techniques for Mammographic Breast Masses, IEEETransactions on Information Technology in Biomedicine, vol. 9, (2005) pp. 109-119

Metrics

1. Measurement of Distributed Separation

(MDS)

Measures used to compare:

The MDS represents :How separated are the distributions of each mammogram

…………………………(3)MDS = |µucalcE -µtissueE |- |µucalc0 -µtissue0 |

µucalcE = Mean of the microcalcification region of the enhanced imageµucalc0 = Mean of the microcalcification region of the original image

µtissueE = Mean of the surrounding tissue of the enhanced imageµtissue0 = Mean of the surrounding tissue of the enhanced image

Defined by:

Where:

Metrics

2. Contrast enhancement of background against

target (CEBT) Measures used to compare:

The CEBT Quantifies :The improvement in difference between the background and the target(MC).

…………………………(4)

0µucalc

Eµucalc0µtissue

0µucalc

Eµtissue

Eµucalc

CEBT

Defined by:

Where:

Eµucalc

0µucalc

= Standard deviations of the microcalcifications region in the enhanced image

= Standard deviations of the microcalcifications region in the original image

Metrics

3. Entropy-based contrast enhancement of

background against target (ECEBT)Measures used to compare:

The ECEBT Measures :- An extension of the TBC metric- Based on the entropy of the regions rather

than in the standard deviations

Defined by:

Where:

…………………………(5)

0µucalc

Eµucalc0µtissue

0µucalc

Eµtissue

Eµucalc

ECEBT

= Entropy of the microcalcifications region in the enhanced image

= Entropy of the microcalcifications region in the original image

Eµucalc

0µucalc

MDS, CEBT and ECEBT metrics on the enhanced mammograms


CT Method DWT Method

MDS CEBT ECEBT MDS CEBT ECEBT

0.853 0.477 0.852 0.153 0.078 0.555

0.818 0.330 0.810 0.094 0.052 0.382

1.000 1.000 1.000 0.210 0.092 0.512

0.905 0.322 0.920 1.000 0.077 1.000

0.936 0.380 0.935 0.038 0.074 0.473

0.948 0.293 0.947 0.469 0.075 0.847

0.665 0.410 0.639 0.369 0.082 0.823

0.740 0.352 0.730 0.340 0.074 0.726

0.944 0.469 0.494 0.479 0.095 0.834

0.931 0.691 0.936 0.479 0.000 0.000

0.693 0.500 0.718 0.258 0.081 0.682

0.916 0.395 0.914 0.796 0.079 0.900

Table 1. Decomposition levels and directions.

0

0.2

0.4

0.6

0.8

1

1.2

TBC

Mammogram

MDS Matrix

CT DWT

The proposed method gives higher results than the wavelet-based method.


Experimental Results Analysis

0

0.2

0.4

0.6

0.8

1

1.2

TBC

E

Mammogram

CEBT Matrix

CT DWT




0

0.2

0.4

0.6

0.8

1

1.2

DSM

Mammogram

ECEBT Matrix

CT DWT




Experimental Results AnalysisMesh plot of a ROI containing microcalcifications

(a)The original mammogram

(mdb252.bmp)

(b) The enhanced mammogram

using CT



(mdb238.bmp)


using CT



(mdb253.bmp)


using CT

More peaks corresponding to microcalcifications are enhanced

The background has a less magnitude with respect to the peaks:-The microcalcifications are more visible.

Observation:



(a)Original image (b)CT method (c)The DWT Method

These regions contain :• Clusters of microcalcifications (target)• surrounding tissue (background).

For visualization purposes :The ROI in the original mammogram are marked with a square.

Plan of action as follows:

1. Segment the microcalcification(MC) from the enhanced image.

2. Find an attribute based on which I can train the machine

2. Based on feature(size/shape), will move on to classification( benign or malignant)

Reference

1. Alqdah M.; Rahmanramli A. and Mahmud R.: A System of MicrocalcificationsDetection and Evaluation of the Radiologist: Comparative Study of the Three MainRaces in Malaysia, Computers in Biology and Medicine, vol. 35, (2005) pp. 905- 914

2. Strickland R.N. and Hahn H.: Wavelet transforms for detecting microcalci¯cationsin mammograms, IEEE Transactions on Medical Imaging, vol. 15, (1996) pp. 218-229

3. Laine A.F., Schuler S., Fan J., Huda W.: Mammographic feature enhancement bymultiscale analysis, IEEE Transactions on Medical Imaging, 1994, vol. 13, no. 4,(1994) pp. 7250-7260

4. Wang T. C and Karayiannis N. B.: Detection of Microcalci¯cations in Digital Mam-mograms Using Wavelets, IEEE Transaction on Medical Imaging, vol. 17, no. 4,(1989) pp. 498-509

5. Nakayama R., Uchiyama Y., Watanabe R., Katsuragawa S., Namba K. and DoiK.: Computer-Aided Diagnosis Scheme for Histological Classi¯cation of ClusteredMicrocalci¯cations on Magni¯cation Mammograms, Medical Physics, vol. 31, no. 4,(2004) 786 – 799

6. Heinlein P., Drexl J. and Schneider Wilfried: Integrated Wavelets for Enhance-ment of Microcalci¯cations in Digital Mammography, IEEE Transactions on Medi-cal Imaging, Vol. 22, (2003) pp. 402-413

7. Daubechies I.: Ten Lectures on Wavelets, Philadelphia, PA, SIAM, (1992)

8. Zhibo Lu, Tianzi Jiang, Guoen Hu, Xin Wang: Contourlet based mammographicimage enhancement, Proc. of SPIE, vol. 6534, (2007) pp. 65340M-1 - 65340M-8

9. Fatemeh Moayedi, Zohreh Azimifar, Reza Boostani, and Serajodin Katebi:Contourlet-based mammography mass classi¯cation, ICIAR 2007, LNCS 4633,(2007) pp. 923-934

Reference

10. Do M. N. and Vetterli M.: The Contourlet Transform: An efficient DirectionalMultiresolution Image Representation, IEEE Transactions on Image Processing, vol.14, (2001) pp. 2091-2106

11. Da Cunha A. L., Zhou J. and Do M. N,: The Nonsubsampled Contourlet Trans-form: Theory, Design, and Applications, IEEE Transactions on Image Processing,vol. 15, (2006) pp. 3089-3101

12. Burt P. J. and Adelson E. H.: The Laplacian pyramid as a compact image code,IEEE Transactions on Communications, vol. 31, no. 4, (1983) pp. 532-540

13. Park S.-I., Smith M. J. T., and Mersereau R. M.: A new directional Filter bank forimage analysis and classification, Proceedings of IEEE International Conference onAcoustics, Speech, and Signal Processing (ICASSP '99), vol. 3, (1999) pp. 1417-1420

14. Sameer S. and Keit B.: An Evaluation on Contrast Enhancement Techniques forMammographic Breast Masses, IEEE Transactions on Information Technology inBiomedicine, vol. 9, (2005) pp. 109-119

Reference

Published PaperAvailable Online:

http://cennser.org/IJCVSP/paper.html

Published

Paper

Available Online:

http://cennser.org/IJCVSP/paper.html

Thank you foryour time and attention

m 2 presentation(final)

Education

brca2 breast cancer

brca1 breast cancer

cue of cancer

better breast cancer

breast use

computer screenmammography

xray picture

goal of mammography