lab hazard recognition and analysis
TRANSCRIPT
Lab-HIRA: Hazard Identification and Risk Analysis for the
Chemical Research Laboratory
Dr. David LeggettLeggett Technical Consulting
Los Angeles, CA
243rd ACS National Meeting San Diego CA, March 2012
Slide A:2
ACS March 2012
LEGGETT
Technical Consulting
A straightforward technique designed to identify and assess the hazards of conducting a chemical synthesis in the research environment.
Once hazards have been recognized appropriate risk minimization or mitigation measures can be implemented by the researcher. An additional formal hazard analysis for the synthesis reaction may be recommended.
Lab-HIRA: Hazard Identification and Risk Assessment
Slide A:3
ACS March 2012
LEGGETT
Technical Consulting
Lab-HIRA: Hazard Identification and Risk Assessment
• An explosion at Sussex University (UK, 1988) seriously injured a student. o UK H&SE prosecuted SU for negligence. o Today, British researchers are required to write down
risk assessments before every experiment.
• Univ. of California (Los Angeles), Texas Tech Univ. & Univ. of Florida have had well-publicized serious accidents in their chemistry labs
Slide A:4
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LEGGETT
Technical Consulting
Lab-HIRA: Hazard Identification and Risk Assessment
• Accident rate is 10 to 50 times higher than that in industrial laboratorieso In industry scientists are required to do a careful hazard
analysis and follow strict safety precautions
o Very few [academic] scientists have taken formal courses in safety, health, and toxicology
o Most relevant safety articles are published in journals devoted outside of an academics major field of interest
A.K. Furr, Handbook of Laboratory Safety (2000)
US Chemical Safety Board, Texas Tech University Laboratory Explosion Case Study (2010)
Slide A:5
ACS March 2012
LEGGETT
Technical Consulting
Chemical Industry Typically Requires Hazards Testing for New Chemistry Destined for Full Scale Manufacture
Scale of Reaction
Type of Hazard Assessment Typical Approaches
Research & Development
Desktop StudySmall Scale Testing
Calculations, Literature,DSC, Mixing Cal, RSST
Pilot or Kilo LabQualitative and Semi-Quantitative Testing
Reaction Calorimetry, Adiabatic Calorimetry
Manufacturing Custom testing for Engineering Design
DIERS, Dust, Reaction Calorimetry, Flammability
Lab-HIRA: Hazard Identification and Risk Assessment
Slide A:6
ACS March 2012
LEGGETT
Technical Consulting
Lab-HIRA: Hazards Identification and Risk Analysis for New Chemistry at Research Scale
Desktop StudySmall Scale Testing
Calculations, Literature
DSC, Mixing Calorimetry, RSST
SWIF or Simple HAZOP, if needed
Lab-HIRA: Hazard Identification and Risk Assessment
Slide A:7
ACS March 2012
LEGGETT
Technical Consulting
Lab-HIRA uses the physical, chemical, and health data for reactants and reactions:
• Flammability – vapors, liquids, solids
• Specific Chemical Hazards
• Health Data – toxicity, exposure, carcinogenicity
• Reaction Conditions
• Equipment such as radiation sources
Lab-HIRA Step 1: Hazard Identification
Slide A:8
ACS March 2012
LEGGETT
Technical Consulting
Four Classes of Data Support Lab-HIRA
Class 1: Property Expressed as Specific Value
Class 2: Hazardous Characteristic of Molecule
Class 3: Reaction Hazards, by Type or Named Rxn
Class 4: Conditions of Synthesis
Lab-HIRA Step 1: Hazard Identification
Slide A:9
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LEGGETT
Technical Consulting
Properties Expressed as Discrete Values
PropertyChemical / Energy
Source Value
IDLH Hydrazine 50 ppm
LD50 (rats) 1,4-Dioxane 5,200 mg kg-1
TWA (OSHA) SO2 5 ppm
Flash Point THF -14 °C
Laser SourceHigh intensity
laser Class 4
Flammability Hexane Class IA
Lab-HIRA Step 1: Hazard Identification
Slide A:10
ACS March 2012
LEGGETT
Technical Consulting
For discrete values, such as LD50, map values to an
index scale 0 thru’ 4
United Nations, Globally Harmonized System of Classification and Labeling of Chemicals (2005)
or
Hazard Index Value
Hazard Min Max
0 No Hazard > 5,000
1 Minimal > 500 5,000
2 Minor > 50 500
3 Moderate 5 50
4 Major < 5
Lab-HIRA Step 1: Hazard Identification
Slide A:11
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LEGGETT
Technical Consulting
Properties are expressed in various units:
PropertyHazard Index Value
0 1 2 3 4Flammability NF / NC IIIB II or IIIA IB or IC IA
Laser Source None Class 1 Class 2 Class 3 Class 4
UV Source, nm None 400-320 320-280 280-100 <100
MIE, mJ > 5 2 - 5 0.5 - 2 0.05 - 0.5 < 0.05
Auto-Ign, °C > 500 350 - 500 250 - 350 150 - 250 < 150
Hazard No Haz Minimal Minor Moderate Major
Lab-HIRA Step 1: Hazard Identification
Slide A:12
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LEGGETT
Technical Consulting
Four Classes of Data
Class 1: Property Expressed as Specific Value
Class 2: Hazardous Characteristic of Molecule
Class 3: Reaction Hazards, by Type or Named Reaction
Class 4: Conditions of Synthesis
Lab-HIRA Step 1: Hazard Identification
Slide A:13
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LEGGETT
Technical Consulting
Hazardous Characteristics of Molecules
Specific HazardInde
x Code
Index Value
Pyrophoric: spontaneously flammable or reactive with air < 130 °F AIR 3
Forms gaseous products during reaction – CO2, CO, H2, N2, C4H10
GAS 2
Suspected carcinogen, teratogen, mutagen or reproductive hazard HLTH 4
Impact or friction sensitive IMPT 3
Molecule requires temperature controlled storage or handling TCN 2
Lab-HIRA Step 1: Hazard Identification
Slide A:14
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LEGGETT
Technical Consulting
Four Classes of Data
Class 1: Property Expressed as Specific Value
Class 2: Hazardous Characteristic of Molecule
Class 3: Reaction Hazards, by Type or Named Rxn
Class 4: Conditions of Synthesis
Lab-HIRA Step 1: Hazard Identification
Slide A:15
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LEGGETT
Technical Consulting
Hazardous Characteristics of Molecules
Reaction Type Reaction Type Index Value
Decarboxylation
Removal of –COOH with CO2 evolved
2
Nitration Red fuming or white HNO3, N2O4 3
Reductions
LiAlH4, N2H4 in KOH, NaBH4 in CH3OH 3
BF3 / NaBH4, H2 + catalyst 2
Esterifications
Oxalyl chloride – high health hazard 3
RCOOH + SOCl2 followed by R’OH
2
Lab-HIRA Step 1: Hazard Identification
Slide A:16
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LEGGETT
Technical Consulting
Hazard Levels of Named Reactions
Reaction Type Reaction Type
Index
Value
Wolff-Kishner Reduction
Reduction of RCHO or R2CO to RH with H2NNH2
3
Grignard Reaction
Reaction of R’MgCl to RCHO or RR”CO to form RR’CHOH or RR’R”COH 3
Kochi Reaction One-carbon oxidative degradation of R-COOH using a Pb(IV) reagent 1
Meerwein-Ponndorf-Verley Reduction
The aluminum-catalyzed hydride shift from the α-carbon of an alcohol reagent to RR’CO forming RR’CHOH
2
Lab-HIRA Step 1: Hazard Identification
Slide A:17
ACS March 2012
LEGGETT
Technical Consulting
Four Classes of Data
Class 1: Property Expressed as Specific Value
Class 2: Hazardous Characteristic of Molecule
Class 3: Reaction Hazards, by Type or Named Reaction
Class 4: Conditions of Synthesis
Lab-HIRA Step 1: Hazard Identification
Slide A:18
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LEGGETT
Technical Consulting
Properties are expressed in various units:
Synthesis Conditions
Hazard Index Value
0 1 2 3 4
TPROCESS, MAX (°C) < 75 75 - 150150 - 250
250 - 400 > 400
PPROCESS (psig) < 10 10 - 25 25 - 75 75 - 150 > 150
TFEED (°C) < 35 35 - 60 60 - 80 80 - 100 > 100
Scale-up Ratio 1 1 - 5 5 - 50 50 - 500 > 500
Reaction Mass (kg) < 0.005 0.005 – 0.1 0.1 - 1 1 - 5 > 5
Lab-HIRA Step 1: Hazard Identification
Slide A:19
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LEGGETT
Technical Consulting
Lab-HIRA compared to OSHA Lab Standard (29 CFR 1910.1450)
Health Properties: Lab-HIRA and 1910.1450
Physical and Chemical Properties: Lab-HIRA only
Reaction Conditions: Lab-HIRA only
Lab-HIRA Step 1: Hazard Identification
Slide A:20
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LEGGETT
Technical Consulting
Overall Hazard Index, OHI given by:
DIS_PR = Discrete property (LD50, Flash Pt.) mapped to range
DIS_CND = Discrete reaction condition (TRXN) mapped to range
CHM_HZ = Index value for specific chemical hazard (AIR, WAT)
NAME = Specific named reaction (Wolff-Kirshner)
TYPE = Type of reaction (Decarboxylation)
Lab-HIRA Step 1: Hazard Identification
TYPENAMECHM_HZDIS_CNDDIS_PRIVIVIVIVIVOHI
Slide A:21
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LEGGETT
Technical Consulting
Case Study 1: Diphenylmethane from Benzophenone, using Wolff-Kishner reaction:
Populate Lab-HIRA Chemical Hazard Review form for:• Benzophenone• Potassium hydroxide pellets• Hydrazine hydrate• Ethylene glycol
KOH, HOCH2CH2OH
H2NNH2 200 °C, Reflux
Lab-HIRA Step 1: Hazard Identification
Slide A:22
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LEGGETT
Technical Consulting
Slide A:23
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LEGGETT
Technical Consulting
ACGIH TLVs
OSHA PEL & NIOSH IDLH
n/a Nuclear Radiation Type
5
B Pt
Dust Expl Severity: ST / Pmax / MIE
Lower Flam Limit
mg/kg
ST Dust Class n/a
Melting & Boiling Pt; AutoIgnition
Flammability (Liquid) LEL / UEL ; Fl Pt v/v%
113
Radiation Sources, Nuclear, Laser, UV
°C
ppm TWA (OSHA) n/a Exposure Limits
Toxicity LD50 oral (rat) 129
TWA (ACGIH) 40 ppm
Slide A:24
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LEGGETT
Technical Consulting
C (ACGIH) n/a
nmn/a UV WavelengthLaser Classn/a
ppm
ppm LC50 inhal Gas (rat)
600
Upper Flam Limit
°C
AutoIgn Temp M Pt 270
7298
-52
Flash Point
mg/kg LD50 skin (rabbit)
570
°C
mJ
50
n/a n/a
Laser Type
IDLH (NIOSH)
°C
v/v%
Pmax psi Vapor MIE
ppmppm1PEL (OSHA)
STEL (ACGIH) 1 ppm
Slide A:25
ACS March 2012
LEGGETT
Technical Consulting
Specific Hazard
Index Code Data for Hydrazine
Index
Value
Flash Point FlPt 72 °C 2
Flam. Liquid FLAM Class IIIA 2
Explosion EXPL LFL = 5; UFL = 98 v/v% 4
Toxic Hazard TOXICLD50 oral = 129mg kg-1; LC50
Inh = 570ppm; LC50 skin = 600mg kg-1
2
Exposure EXPOS IDLH = 50 ppm;PEL = 1ppm; TLV = 40ppm 4
AI Temperature AIT 270 °C 2
Fl. Pt vs BPt FPBP FlPt = 72 °C; BPt = 113 °C; Rxn T = 200 °C 2
Lab-HIRA Step 1: Hazard Identification
Slide A:26
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Technical Consulting
FlPt 2 FLAM 2 EXPL 4 TOXIC 2 EXPOS 4
AIT 2 FPBP 2
Slide A:27
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Technical Consulting
Severe A formal Risk Analysis MUST be performed for this chemical
Slide A:28
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Technical Consulting
Repeat data entry for other reactants
Review results of Hazard Identification and Risk Analysis on Reaction Summary:
• Potentially Hazardous Reaction Conditions
• Summary of Hazard Properties of all Reagents
• Potentially Hazardous Reaction Chemistry
• Additional Concerns
• Recommendations for Additional Hazard Review
Lab-HIRA Step 1: Hazard Identification
Slide A:29
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Technical Consulting
Slide A:30
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Technical Consulting
200 °C
25 °C
25 °C
0 psig
0 psig
Conversion of Existing Hazardous Functional Group (y/n)
1
y
Reaction performed less than 3 times (y/n)
Hazardous Functional Group Added to Molecule (y/n)
n
n
Hazard Rating for Reaction Hazard
Maximum pressure of feed
Maximum pressure of reaction
Maximum temperature of feed
Minimum reaction temperature
Minor
Hazards of Reaction Conditions (Check all that apply)
y
Maximum reaction temperature
Scale-up reaction? Enter scale-up factor (Default = 1)
Reaction to be run unattended (y/n)
Slide A:31
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LEGGETT
Technical Consulting
Toxi
c ba
sed
on L
C(D
) 50 v
alue
s fo
r O
ral,
Skin
or I
nhal
ation
Expo
sure
bas
ed o
n TL
V,
PEL,
or I
DLH
Clas
sific
ation
of F
lam
mab
le o
r Co
mbu
stibl
e Li
quid
Min
imum
Igni
tion
Ener
gy
(Vap
or o
r Gas
)
Aut
oign
ition
Haz
ard
TOXIC EXPOS FLAM MIE-V AIT
1 Hydrazine hydrate y y y n y
2 Benzophenone y y n n n
3 Potassium Hydroxide y n n n n
4 Diethylene glycol y n y n y
5
6
.
Check Safeguards Compliance
Slide A:32
ACS March 2012
LEGGETT
Technical Consulting Major
The reduction of aldehydes and ketones to alkanes. Condensation of the carbonyl compound with hydrazine forms the hydrazone, and treatment with base induces the reduction of the carbon coupled with oxidation of the hydrazine to gaseous nitrogen, to yield the corresponding alkane. The Huang-Minlon modification removes water and excess hydrazine by distillation, using a Dean Stark distillation trap, so that he reaction temperature can rise to 200 C. This allows the use of the cheaper hydrazine hydrate in place of anhydrous hydrazine. The Clemmensen Reduction can effect a similar conversion under strongly acidic conditions, and is useful if the starting material is base-labile.
Wolff-Kishner Reduction
Named Reaction Hazard Rating
Hazard Rating for Named Reactions
Wolff-Kishner Reduction
Slide A:33
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LEGGETT
Technical Consulting
138 °C
25 °C
25 °C
0 psig
0 psig
Major
Toxi
c ba
sed
on L
C(D
) 50 v
alue
s fo
r O
ral,
Skin
or I
nhal
ation
Expo
sure
bas
ed o
n TL
V,
PEL,
or I
DLH
Clas
sific
ation
of F
lam
mab
le o
r Co
mbu
stibl
e Li
quid
Min
imum
Igni
tion
Ener
gy
(Vap
or o
r Gas
)
Aut
oign
ition
Haz
ard
Expl
osiv
e Va
por
Flas
h Po
int H
azar
d
Ioni
zing
Rad
iatio
n (a
lpha
, bet
a, g
amm
a, X
-Ray
)
Lase
r Sou
rce
(Cla
ss 1
, 2, 3
, or 4
)
UV
Radi
ation
Sou
rce
(100
to 4
00 n
m)
Stro
ng O
xidi
zer /
Red
ucer
Stati
c Se
nsiti
ve
Easi
ly P
olym
eriz
es
Susp
ecte
d Ca
ncer
, Mut
agen
ic,
Birt
h D
efec
ts, T
erat
ogen
ic R
isk
Wat
er re
activ
e
Air
Sen
sitiv
e
Pero
xide
For
mer
Hig
h Re
actio
n Ra
te
Impa
ct /
Fri
ction
Sen
sitiv
e
Tem
p co
ntro
l nee
ded
for s
tora
ge
Sens
itize
r
Seco
ndar
y Ru
naw
ay R
eacti
on(s
)
Gas
form
ed d
urin
g re
actio
n
TOXIC EXPOS FLAM MIE-V AIT EXPL FlPt NUCL LASER UV RDOX STAT POLY HLTH WAT AIR PERX HIRR IMPT TCN SENS RUN GAS
1 Hydrazine hydrate y y y n y y y n n n y n n y n n n n n n y n n 28 Severe
2 Benzophenone y y n n n y n n n n n n n n n n n n n n y n n 8 Minor
3 Potassium Hydroxide y n n n n n n n n n n n n n y n n y n n n n n 9 Minor
4 Diethylene glycol y n y n y y y n n n n n n n n n n n n n n n n 7 Minor
5 No Hazard
6 No Hazard
7 No Hazard
8 No Hazard
9 No Hazard
10 No Hazard
Overall Hazard Ratings and Recommendations
SEVERE HAZARD: Consider substituting one or more reagents for less hazardous compounds. Perform a Risk Analysis focusing on reagent handling and use.
At least one reactant, or solvent, has a flash point 25 C, or lower, than the planned max reaction temperature (138 C)
NO HAZARD
MAJOR HAZARD: Perform a Risk Analysis focusing on the reactive chemistry and synthetic methods for this step
Additional Concerns
Maximum reaction temperature
Scale-up reaction? Enter scale-up factor (Default = 1)
Reaction to be run unattended (y/n)
Reaction performed less than 3 times (y/n)
Standad Synthesis Protocols Followed? (Provide reference)
Named Reaction Hazard Rating
Hazardous Functional Group Added to Molecule (y/n)
n
n
Hazard Rating for Reaction Hazard
Maximum pressure of feed
Maximum pressure of reaction
Maximum temperature of feed
Minimum reaction temperature
No HazardHazard Rating for Reaction Classes Hazard Rating for Named Reactions Minimal
Hazards of Reaction Conditions (Check all that apply)
Name of Reviewer
Name of Chemist
Documentation for Hazard Review
3/2/1912
3/1/1912
y
Use Named Reactions Hazards
n
y
n
y n
COR
Wolff-Kishner Reduction
n
n
y
Use the named reactions hazards to evaluate the potential hazards
Lab-HIRA Hazard Assessments for Synthesis Step
Section 3: Hazard Ratings, Recommendations and Documentation for Lab-HIRA Review
Section 1: Named Reaction or Reaction Class and Reaction Conditions for Step 1 of the Diphenylmethane synthesis
Section 2: Summary Table of Reagents Used During Step 1 of the Diphenylmethane synthesis.
Chemical Hazards Score
and RatingRe
actio
n Te
mpe
ratu
re
> Fl
ash
Poin
t
Hig
h Co
rros
ivity
FPBP
Reaction Class Hazard Rating
Conversion of Existing Hazardous Functional Group (y/n)
The reduction of aldehydes and ketones to alkanes. Condensation of the carbonyl compound with hydrazine forms the hydrazone, and treatment with base induces the reduction of the carbon coupled with oxidation of the hydrazine to gaseous nitrogen, to yield the corresponding alkane. The Huang-Minlon modification removes water and excess hydrazine by distillation, using a Dean Stark distillation trap, so that he reaction temperature can rise to 200 C. This allows the use of the cheaper hydrazine hydrate in place of anhydrous hydrazine. The Clemmensen Reduction can effect a similar conversion under strongly acidic conditions, and is useful if the starting material is base-labile.
1
y
Lab-HIRA © Copyright Leggett Technical Consulting 2008 - 2011. Version 4.5; Date November, 2011
Use of Hazardous Chemicals
Hazard Potential of Reaction Chemistry
Hazard Potential of Reaction Conditions
Date Form Completed
Date Form Reviewed
Rudolp Fittig
Ludwig Kirshner
Location of notes and other related documention for this hazard review
Check Safeguards Compliance
Use Named Reactions Hazards Wolff-Kishner Reduction
Use of Hazardous Chemicals
Hazard Potential of Reaction Chemistry
Hazard Potential of Reaction Conditions
Overall Hazard Ratings and Recommendations
SEVERE HAZARD: Consider substituting one or more reagents for less hazardous compounds. Perform a Risk Analysis focusing on reagent handling and use.
At least one reactant, or solvent, has a flash point 25 C, or lower, than the planned max reaction temperature (200 C)
MINOR HAZARD: No Additional Risk Analysis needed
MAJOR HAZARD: Perform a Risk Analysis focusing on the reactive chemistry and synthetic methods for this step
Additional Concerns
Slide A:34
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LEGGETT
Technical Consulting
Case Study 2:
• Synthesis of a vinyldecane derivative using t-BuLi.
• Researcher was exposed to t-BuLi during a transfer.
• The nitrile gloves and synthetic sweater, worn by the
researcher at the time of the accident, caught fire;
the chemist was not wearing a lab coat at the time.
• She received burns over 40% of her body and died a
few weeks later.
How would Lab-HIRA have helped in this situation?
Lab-HIRA Step 1: Hazard Identification
Slide A:35
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Technical Consulting
Lab-HIRA produces a Safeguards Com-pliance Checklist for each reagent, including PPE recommendations
13 Handling techniques for these chemicals have been reviewed and approved by Chemical Safety Committee Hazard Codes: AIR
14 Written contingency plans are available covering worst case accident scenarios Hazard Codes: WAT, AIR
Signed: ____________________________________
Print Name: ________________________________
Grad Student Post Doc Supervisor
Date: _________
Safeguards Required to Work With This Material
Use Safe-
guard? (Y/N)
Describe other risk reduction measures
1 Confirm that only Class I Division 2 rated electrical equipment will be used during this synthesis
Hazard Codes: WAT, AIR, EXPL, FLAM
2 Consider using a glove box or bag to handle t-Bu Lithium
Hazard Codes: WAT, AIR
3 Material transfers will be done in the hood, glove box or bag. Open-bench work prohibited for this chemical
Hazard Codes: WAT, AIR, TCN
Lab-HIRA Step 1: Hazard Identification
Slide A:36
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Technical Consulting
Lab-HIRA Step 2: Risk Assessment
Lab-HIRA may recommend a formal risk analysis such as a What-If or procedural HAZOP
• Chose the hazard analysis technique• Assemble necessary documentation
• Conduct risk analysis
• Evaluate recommendations for risk reduction• Close out recommendations
o Items to be completed before beginning worko Schedule other items for timely completion
• Document Lab-HIRA findings
Slide A:37
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Technical Consulting
Lab-HIRA Step 2: Risk Assessment
A typical synthesis procedure for Case Study 1:
In a suitable fume hood set up a nitrogen-purged multi-neck flask
equipped with an agitator, reflux condenser, Dean-Stark trap, and
temperature controller.
Suspend the ketone (85 g) in an alkylene glycol (~2 L).
Place the flask in a room temperature oil bath then add KOH (70 g).
Gradually add 80% solution of hydrazine hydrate (65 mL).
Heat the reaction mixture slowly heated to 200oC ………
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Technical Consulting
Lab-HIRA Step 2: Risk Assessment
Action: Install and set a temperature controller for reactor
What-If Scenario 1: Temperature controller incorrectly set up or fails
Consequence: Failure to control reaction temperature; possible runaway reaction; possible loss of containment
Risk Assessment: Major, if consequence plays out
Current Safeguards: Chemist monitors reaction regularly
Recommendation: Determine if runaway is possible; consider using redundant T controller if true
Slide A:39
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Technical Consulting
Lab-HIRA Step 2: Risk Assessment
Action: Install and set a temperature controller for reactor
What-If Scenario 2: Runaway reaction occurs before evasive action can be taken?
Consequence: Probable loss of containment; possible fire/ explosion
Risk Assessment: Severe, if consequence plays out
Current Safeguards: None at present – no GS willing to camp out beside fume hood
Recommendation: Determine if runaway is possible; consider using redundant T controller if true; do not perform overnight runs for this reaction
Slide A:40
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Technical Consulting
Lab-HIRA: Summary and Conclusions
• Lab-HIRA identifies and assesses reaction hazards and gives guidance about formal hazard review.
• Designed for use by chemists who have sufficient knowledge to safely handle the chemicals and the equipment planned for the synthesis.
• The hazard potential may be estimated from readily available physical, chemical, and health data.
• Thirty three parameters, indicative of one or more hazardous properties of molecules or synthesis conditions, are used to assess the reaction hazards.
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Technical Consulting
Lab-HIRA: Summary and Conclusions
• The risk-based assessments tend to be conservative.
• Once hazards have been recognized appropriate risk reduction measures can be implemented.
• If a formal hazard analysis for the synthesis reactions is indicated then techniques, such as Check-List, What-If, SWIF or HAZOP are available.
• Thermal hazards testing may be required to quantify the consequences of equipment upsets or procedural short-comings.
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Technical Consulting
Lab-HIRA: Summary and Conclusions
Only open literature data are used. Some hazards associated with the synthesis reaction may be missed. It is the responsibility of the user to determine the adequacy of the hazard identification and risk analysis of their synthesis.
Slide A:43
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Technical Consulting
D. Leggett, Lab-HIRA: Hazard Identification and Risk Analysis for the Chemical Research Laboratory: Part 1. Preliminary Hazard Evaluation, J. Chem. Health & Safety, In press
DOI 10.1016/j.jchas. 2012.01.012
D. Leggett, Lab-HIRA: Hazard Identification and Risk Analysis for the Chemical Research Laboratory: Part 2. Risk Analysis of Laboratory Operations, J. Chem. Health & Safety, In press
DOI 10.1016/j.jchas.2012.01.013
Lab-HIRA: Publications