krok 1 - 2013 question paper (pharmacy)

21
Krok 1 Pharmacy 2013 1 1. An excess of concentrated ammoni- um hydroxide is a group reagent for the cations of the VI analytical group (acid-base classication), namely Co 2+ , Ni 2+ , Cd 2+ , Cu 2+ , Hg 2+ . As a result of this reaction the following substances are formed: A. Water-soluble ammonia complexes B. Hydroxides of acid-soluble cations C. Stained water-insoluble compounds D. Hydroxides of alkali-soluble cations E. Hydroxides of the cations insoluble in the excess of ammonium hydroxide 2. Which of the listed reactions demonstrates the basic properties of pyri- dine? A. B. C. D. E. 3. A patient with stenocardia has been administered acetylsalicylic acid for: A. Antiplatelet effect B. Inhibition of blood brinolytic activity C. Aggregate effect D. Anti-inammatory effect E. Increase in blood brinolytic activity 4. On the 4th day of treatment with indomethacin a male 55-year-old pati- ent developed gastric bleeding due to the ulceration of the gastric mucosa. Ulcerogenic effect of the drug is associ- ated with a decrease in the activity of the following enzyme: A. Cyclooxygenase-1 B. Cyclooxygenase-2 C. Lipoxygenase D. Thromboxane synthetase E. Prostacyclin synthase 5. A patient with hypertensive crisis has been given an intravenous injection of clonidine. What mechanism underlies the antihypertensive effect of clonidine? A. Stimulation of presynaptic central α 2 -adrenoceptors B. Blockade of peripheral α 1 - adrenoceptors C. Blockade of β -adrenoceptors D. Blockade of N -cholinergic receptors E. Direct myotropic effect on blood vessels 6. A patient with ischemic heart disease has been administered inosine which is an intermediate metabolite in the synthesis of: A. Purine nucleotides B. Metalloproteins C. Lipoproteins D. Glycoproteins E. Ketone bodies 7. A patient with hypertensive crisis should be administered a diuretic as a part of complex therapy. What drug should be given the patient? A. Furosemide B. Diacarb C. Spironolactone D. Triamterene E. Amiloride 8. Rates of chemical reactions of the same order are compared by: A. Constant of chemical reaction rate B. Chemical reaction rate C. Endpoint of a reaction D. Change in the reactants concentration E. Change in the concentration of the reaction products 9. Consult a patient on which antihistami- ne drug DOES NOT have sedative and hypnotic effect:

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Page 1: Krok 1 - 2013 Question Paper (Pharmacy)

Krok 1 Pharmacy 2013 1

1. An excess of concentrated ammoni-um hydroxide is a group reagent forthe cations of the VI analytical group(acid-base classification), namely Co2+,Ni2+, Cd2+, Cu2+, Hg2+. As a result ofthis reaction the following substances areformed:

A. Water-soluble ammonia complexesB. Hydroxides of acid-soluble cationsC. Stained water-insoluble compoundsD. Hydroxides of alkali-soluble cationsE. Hydroxides of the cations insoluble inthe excess of ammonium hydroxide

2. Which of the listed reactionsdemonstrates the basic properties of pyri-dine?

A.

B.

C.

D.

E.

3. A patient with stenocardia has beenadministered acetylsalicylic acid for:

A. Antiplatelet effectB. Inhibition of blood fibrinolytic activityC. Aggregate effectD. Anti-inflammatory effectE. Increase in blood fibrinolytic activity

4. On the 4th day of treatment withindomethacin a male 55-year-old pati-

ent developed gastric bleeding due tothe ulceration of the gastric mucosa.Ulcerogenic effect of the drug is associ-ated with a decrease in the activity of thefollowing enzyme:

A. Cyclooxygenase-1B. Cyclooxygenase-2C. LipoxygenaseD. Thromboxane synthetaseE. Prostacyclin synthase

5. A patient with hypertensive crisis hasbeen given an intravenous injection ofclonidine. What mechanism underlies theantihypertensive effect of clonidine?

A. Stimulation of presynaptic centralα2-adrenoceptorsB. Blockade of peripheral α1-adrenoceptorsC. Blockade of β-adrenoceptorsD. Blockade of N-cholinergic receptorsE. Direct myotropic effect on blood vessels

6. A patient with ischemic heart diseasehas been administered inosine which is anintermediate metabolite in the synthesisof:

A. Purine nucleotidesB. MetalloproteinsC. LipoproteinsD. GlycoproteinsE. Ketone bodies

7. A patient with hypertensive crisisshould be administered a diuretic as a partof complex therapy. What drug should begiven the patient?

A. FurosemideB. DiacarbC. SpironolactoneD. TriamtereneE. Amiloride

8. Rates of chemical reactions of the sameorder are compared by:

A. Constant of chemical reaction rateB. Chemical reaction rateC. Endpoint of a reactionD. Change in the reactants concentrationE. Change in the concentration of thereaction products

9. Consult a patient on which antihistami-ne drug DOES NOT have sedative andhypnotic effect:

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A. LoradatineB. DiphenhydramineC. PromethazineD. SuprastinumE. Tavegil (Clemastine)

10. Solutions of some electrolytes areused as medications. What is the maxi-mum value of the isotonic coefficient forMgSO4 solution?

A. 2B. 4C. 3D. 5E. 7

11. A patient with hypertension has beenprescribed a drug that blocks angiotensinreceptors. Specify this drug:

A. LosartanB. NifedipineC. PrazosinD. CaptoprilE. Apressin

12. A patient with gastric ulcer has beenadministered omeprazole. What is themechanism of its action?

A. Inhibition of H+K+-ATPaseB. Blockade of histamine H2-receptorsC. M-cholinergic receptor blockadeD. Neutralization of HClE. Stimulation of mucus production

13. Which of these formulas correspondswith acetoacetic acid?

A.

B.

C.

D.

E.

14. After taking phenacetin a pati-ent developed acute sore throat, fever.Examination enabled doctors to makea diagnosis of necrotic angina andagranulocytosis. Agranulocytosis can becharacterized by a decrease in the amountof the following WBCs:

A. NeutrophilsB. EosinophilsC. BasophilsD. LymphocytesE. Monocytes

15. A patient with a heart rhythm disorderhas been given lidocaine. Apart from thelocal anesthetic effect, this drug has thefollowing pharmacological effect:

A. AntiarrhythmicB. HypnoticC. AntipyreticD. AntidepressantE. Nootropic

16. A patient with chronic constipationhas been prescribed bisacodyl. After 3weeks of treatment, the patient noticed areduction of laxative effect. This is causedby the development of the following side-effect:

A. HabituationB. DependenceC. SensibilizationD. CumulationE. Dysbacteriosis

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17. It is not advisable to use antacids andiron supplements at the same time for thefollowing reason:

A. Malabsorption of ironB. Increased binding to plasma proteinsC. Impaired deposition of iron in the bodyD. Increased intoxication with ironE. Accelerated elimination of iron

18. A patient with acute heart failure andcardiac glycosides intolerance was givenan injection of dobutamine. What is themechanism of its action?

A. Stimulation of β1-adrenoceptorsB. Stimulation of α1-adrenoceptorsC. Blockade of K+-, Na+-ATPaseD. Inhibition of phosphodiesterase activityE. Stimulation of M-cholinergic receptors

19. A female patient asked a pharmacistto recommend her a drug for headachewith antiplatelet effect. Specify this drug:

A. Acetylsalicylic acidB. Codeine phosphateC. PromedolD. TramadolE. Fentanyl

20. A plant under examination has papi-lionaceous flowers. This plant belongs tothe following family:

A. FabaceaeB. ScrofulariaceaeC. RanunculaceaeD. LamiaceaeE. Asteraceae

21. Microscopic analysis of a root revealedthe following features: primary structure,endodermal cells with horseshoe-shapedareas, radial fascicle of the central cyli-nder, more than six xylem rays. Suchroot structure is typical for the followi-ng plants:

A. Angiosperms, monocotyledonsB. Angiosperms, dicotyledonsC. Gymnosperms, conifersD. Gymnosperms, gnetaliansE. Pteridosperms

22. Chronic pancreatitis is accompaniedby the decreased synthesis and secretionof trypsin. This impairs the hydrolysis andabsorption of the following substances:

A. ProteinsB. LipidsC. PolysaccharidesD. Nucleic acidsE. Disaccharides

23. Analysis of a plant revealed essential-oil glands with several layers of cellsarranged in pairs. This allows for thepossibility that the plant relates to thefamily:

A. AsteraceaeB. ScrofulariaceaeC. SolanaceaeD. ApiaceaeE. Lamiaceae

24. In an emergency situation a scuba di-ver has quickly risen from the depths tothe surface, which is against the rule. Heis unconscious, exhibits respiratory failureand cardiac activity disorder as a result ofdecompression sickness. What complicati-on may develop in the scuba diver?

A. Gas embolismB. Fat embolismC. Air embolismD. Cellular embolismE. Thromboembolism

25. A patient has been hospitalized forchronic heart failure. Objectively: skinand mucous membranes are cyanotic, thepatient has tachycardia, tachypnea. Whattype of hypoxia has developed in the pati-ent?

A. CirculatoryB. AnemicC. HemicD. TissueE. Hypoxic

26. What are the indications for the use ofnaloxone?

A. Acute intoxication with narcoticanalgesicsB. Heavy metal intoxicationC. Intoxication with cardiac glycosidesD. Intoxication with ergot alkaloidsE. Atropine sulfate intoxication

27. Amino group of p-aminobenzoic acidis involved into reaction with the followi-ng reagent:

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A. HClB. NH4OHC. NaOHD. CH3COONaE. KCN

28. A patient with renal colic has beenadministered a spasmolytic from thegroup of M-cholinergic antagonists as apart of the complex therapy. Specify thisdrug:

A. AtropineB. ProserinC. GalantamineD. DithylinumE. Benzohexonium

29. What drug is administered in case ofuterine inertia?

A. OxytocinB. No-spaC. ProgesteroneD. VikasolumE. Fenoterol

30. A patient with myocardial infarctionhas been administered intravenously a di-rect anticoagulant, namely:

A. HeparinB. NeodicumarinumC. VikasolD. ThrombinE. Calcium gluconate

31. What drug should be administered forindividual prevention of malaria?

A. ChingaminB. RifampicinC. AmpicillinD. GentamicinE. Biseptol (Co-Trimoxazolel)

32. A sample section of an axial bodyshows a complex consisting of phellogenand its derivatives - cork and phelloderm.This tissue is called:

A. PeridermB. ColenchymaC. SclerenchymaD. EpiblemaE. Epidermis

33. A pharmacy dispenses glaucinehydrochloride to a patient with chronicbronchitis. The patient must be warnedabout the following typical side effect ofthe drug:

A. Blood pressure fallB. Excitation of the central nervous systemC. ArrhythmiaD. Rise of intraocular pressureE. Allergic skin rash

34. A solution contains cations of zincand aluminium. Specify the reagent thatmakes it possible to detect cations of zincin this solution:

A. Potassium hexacyanoferrate (II) soluti-onB. Sodium hydroxide solutionC. Cobalt nitrate Co(NO3)2

D. Excess of 6M sodium hydroxide inpresence of hydrogen peroxideE. Sulfuric acid solution

35. A medicament comprises sodium bi-carbonate and sodium chloride. Whatmethod is used for quantitative determi-nation of sodium bicarbonate?

A. Acid-base titrationB. Precipitation titrationC. Redox titrationD. Complexometric titrationE. Coulometric titration

36. Concentration of magnesium sulfatein a drug can be determined bycomplexometric titration. Select an indi-cator for fixing the end point of titration:

A. Chromogen blackB. PhenolphtaleinC. Methyl orangeD. DiphenylcarbazoneE. -

37. Select a pair of electrodes for potenti-ometric pH measurement of a solution:

A. Glass and silver chlorideB. Calomel and silver chlorideC. Quinhydrone and antimonialD. Mercury sulphate and silver chlorideE. Glass and antimonial

38. The mass percentage of ascorbic acidcan be determined by the cerimetricanalysis in the presence of the followingredox indicator:

A. FerroinB. Methylene redC. EosinD. FluoresceinE. Methylene orange

39. An injured person exhibits the followi-ng signs at the site of trauma: skinredness, throbbing small arteries, elevated

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local temperature, increased tissue turgor.What local blood circulation disorder arethese presentations typical for?

A. Arterial hyperemiaB. Venous hyperemiaC. ThrombosisD. EmbolismE. Ischemia

40. Microscopic examination of aperennial stem revealed the secondaryintegumentary tissue that was formed as aresult of cell division of:

A. PhellogenB. ProcambiumC. CambiumD. PericycleE. Protoderma

41. What synthetic drug of the hydrazi-de group is typically prescribed forpulmonary tuberculosis?

A. IsoniazidB. RifampicinC. AcyclovirD. MetronidazoleE. Doxycycline hydrochloride

42. A female student with a cold hasbeen prescribed an antipyretic medicati-on. Specify this drug:

A. ParacetamolB. Ascorbic acidC. OxytocinD. FamotidineE. Cyanocobalamin

43. Specify the drug that constricts pupilsand reduces intraocular pressure:

A. Pilocarpine hydrochlorideB. FenofibrateC. NitrazepamumD. Atropine sulfateE. Dithylinum

44. A plant under study has stipules fusedtogether and thus forming a tight tube -ochrea, that is a diagnostic feature of thefollowing family:

A. PolygonaceaeB. GramineaeC. RosaceaeD. PapaveraceaeE. Clusiaceae

45. A 42-year-old female has foamy-purulent vaginal discharges. The smearstained by Romanovsky-Giemsa’s method

has been found to include flagellatedbacteria. What is the most likely mi-croorganism that has been found by thedoctor?

A. Trihomonas vaginalisB. Leishmania donovaniC. Trypanosoma gambienseD. Trihomonas hominisE. Lamblia intestinalis

46. A patient has been taking diclofenacsodium for a long time. The family physi-cian withdrew this drug and administeredcelecoxib. What disease was the reasonfor the drug substitution?

A. Peptic ulcerB. Bronchial asthmaC. UrolithiasisD. Arterial hypertensionE. Chronic hepatitis

47. The rate of a chemical reaction DOESNOT DEPEND on the concentration ofthe reactants. Specify the order of suchreaction:

A. ZerothB. FirstC. SecondD. ThirdE. Fraction

48. A patient has been diagnosed withbronchial asthma. Specify a medicamentthat can be administered for asphyxiation:

A. SalbutamolB. Diclofenac sodiumC. ParacetamolD. AnaprilineE. Acetylcysteine

49. Sulfanilamides inhibit the growth anddevelopment of bacteria. The mechanismof their action is based on the impairmentof the following acid synthesis:

A. FolicB. LipoicC. NicotinicD. PantothenicE. Pangamic

50. Sulfanilamides are widely used asbacteriostatic agents. The mechanism ofantimicrobial action of sulfanilamides isbased on their structural similarity to:

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A. Para-aminobenzoic acidB. Glutamic acidC. Folic acidD. Nucleic acidE. Antibiotics

51. Specify the standard solution for theiodometric determination of reducingagents (direct titration):

A. I2

B. KMnO4

C. Na2S2O3

D. K2Cr2O7

E. KI

52. The fourth group of cations includesthe cations Al3+, Sn2+, Sn(IV ), As(V ),As(III), Zn2+, C3+. The group reagentfor the fourth group of cations is thesolution of:

A. NaOH , H2O2

B. HClC. NH3, H2O2

D. H2C2O4

E. H2SO4, H2O2

53. In a qualitative analysis, when anexcess of the group reagent (NH3 soluti-on) reacts with the cations of the si-xth analytical group (Cu2+, Co2+, Ni2+,Cd2+, Hg2+), the following compoundsare formed:

A. Metal ammine complexesB. Metal hydroxidesC. Basic metal saltsD. Aqua complexes of metalsE. Hydroxocomplexes of metals

54. Sodium fluoride is one of thecomponents of the drugs used in thetreatment of dental caries. NaF reacts wi-th the following compound:

A. H2SO4

B. CO2

C. NaClD. KIE. CH3COOH

55. The most common technology inpharmaceutical production is maintainingconstant temperature and pressure. Whatis this process called?

A. Isobaric-isothermalB. Isochoric-isothermalC. IsobaricD. IsochoricE. Isothermal

56. Some medications are colloidal soluti-ons. What size of the colloidal particles istypical for the colloidal dispersion?

A. 10−7 - 10−9 мB. 10−5 - 10−7 мC. 10−10 - 10−11 мD. 10−5 - 10−3 мE. > 10−3 м

57. To maintain a certain level of pH-medium, the buffer solutions are used.Specify a composition of substances thatDOES NOT EXHIBIT buffer properties:

A. NaOH + NaClB. CH3COOH + CH3COONaC. NH4Cl + NH3·H2OD. HCOOH + HCOONaE. NaH2PO4 + Na2HPO4

58. What non-narcotic centrally-actingantitussive drug can be used for drycough?

A. GlaucineB. CodeineC. AcetylcysteineD. AmbroxolE. Mucaltinum

59. What analytical effect is observed afterfixing the endpoint during the titration byMohr method?

A. Brick-red precipitateB. Red colour of solutionC. Yellow colour of solutionD. White precipitateE. Yellow precipitate

60. What solution can be determinedby photocolorimetric method by self-absorbance?

A. Potassium chromateB. Potassium chlorideC. Potassium sulphateD. Potassium nitrateE. Potassium phosphate

61. What substance in a solution can bedetermined in two ways - by the polari-metric or refractometric method?

A. Ascorbic acidB. Sodium benzoateC. Benzoic acidD. Calcium gluconateE. Magnesium sulfate

62. A patient with symptoms ofchronic bronchitis has been administeredacetylcysteine. What is the mechanism of

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its expectorant action?

A. Depolymerization of sputummucopolysaccharidesB. Stimulation of adrenergic receptorsC. Inhibition of cough centerD. Stimulation of respiratory centerE. Anesthesia of respiratory mucosa

63. During the gastric secretion,proteolytic enzymes are secreted in formof zymogens. What enzyme is activated byhydrochloric acid?

A. PepsinB. TrypsinC. AmylaseD. LipaseE. Chymotrypsin

64. Specify the reaction product of purinereacting with sodium hydroxide:

A.

B.

C.

D.

E.

65. What class of reactions does thisreaction relate to?

A. AdditionB. SubstitutionC. ReductionD. OxidationE. Rearrangement

66. The combined use of furosemide withaminoglycoside antibiotics causes:

A. Hearing impairmentB. Increased blood pressureC. CrampsD. HyperhidrosisE. Increased intraocular pressure

67. A child exhibits physical and mentalretardation. Urine analysis revealed highconcentration of orotic acid. This diseasecan be addressed by the constant use of:

A. UridineB. AdenineC. GuanineD. GlutamineE. Alanine

68. To distinguish between phenol andsalicylic acid, the following reagent isused:

A. Sodium bicarbonate solutionB. Iron (III) chloride solutionC. Sodium hydroxide solutionD. Sodium chloride solutionE. Bromine solution

69. Ethane is the product of the followingreaction:

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A.CH2 = CH2

H2,cat.−−−−→to,p

B.Al4C3

H2O−−→

C.CO + 2H2

Fe,to−−−→

D.C2H5OH

k.H2SO4,to−−−−−−→

E. -

70. What titrants are used for the titrationin the non-aqueous medium?

A. Perchloric acid and sodium ethylateB. Sulfuric acid and barium hydroxideC. Hydrochloric acid and potassiumethylateD. Nitric acid and sodium hydroxideE. Perchloric acid and barium hydroxide

71. There are areas where humans or ani-mals are exposed to the constant riskof contracting certain types of bacteria.What feature of these bacteria is responsi-ble for their long viability in the soil?

A. Spore formationB. Capsule formationC. Ability to multiply in the plant remainsD. Thick cell wallE. Plasmids

72. What reagents are used to separate thecations of the IV analytical group from thecations of the V and VI analytical groupsin the analysis of their composition?

A. NaOH and H2O2

B. H2SO4

C. DithizoneD. NH4OHE. Na2S

73. Specify the standard substance for thestandardization of 0,1 M of hydrochloricacid solution:

A. Sodium carbonateB. Ammonium hydroxideC. Oxalic acidD. Sodium chlorideE. Zinc sulphate

74. A patient with a diagnosis of drug poi-soning has been admitted to the resusci-tation department. The patient is in grave

condition. Respiration is rapid, superfi-cial, with periods of apnea (Biot’s respi-ration). What was the main cause of thedevelopment of periodic breathing in thepatient?

A. Inhibition of the respiratory centerfunctionB. Impaired function of spinal cordmotoneuronsC. Impaired function of the neuromuscularsystemD. Diminished chest mobilityE. Pulmonary dysfunction

75. Specify the number of electronsinvolved into formation of the isolatedconjugated system in the pyrimidinemolecule:

A. 6B. 4C. 10D. 2E. 8

76. In course of long-term treatment ofan infectious patient with penicillin, thepathogen transformed into the L-form.What changes occur in the pathogen cellin case of L-transformation?

A. Absence of a cell wallB. Absence of flagellaC. Absence of a capsuleD. Absence of a sporeE. Absence of inclusions

77. Dosage forms produced as coarse di-spersion systems with the liquid dispersi-on medium and the solid phase are called:

A. SuspensionB. EmulsionC. AerosolD. PowderE. Foam

78. Ethanol can be distinguished fromglycerol by the reaction with the followingreagent:

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A. Cu(OH)2

B. HBrC. FeCl3D. KMnO4

E. Ag2O

79. A patient was found to have atumor of the pancreatic head, which isaccompanied by the impaired patencyof the common bile duct. Blood test wi-ll reveal an increase in the followingsubstance level:

A. BilirubinB. UreaC. HemoglobinD. InsulinE. Adrenaline

80. On the 2nd day after developing acuteinflammation of the knee joint, the patientexhibits the joint enlargement, swelling ofthe skin. At what stage of inflammationare these signs typically observed?

A. ExudationB. AlterationC. ProliferationD. RegenerationE. Sclerosis

81. Quite often, the soil may contain anumber of pathogenic microorganisms.The causative agents of the following di-sease may stay viable in the soil for a longtime:

A. AnthraxB. DiphtheriaC. Viral hepatitisD. PertussisE. Dysentery

82. As a result of an accident (snakebi-te) a male patient has the following bloodvalues: Hb- 80 g/l, RBC- 3, 0 ·1012/l; WBC-5, 5·109/l. What type of anemia is observedin this case?

A. HemolyticB. Folic acid-deficiencyC. PosthemorrhagicD. AplasticE. Iron-deficiency

83. Emulsions of 0,1 - 74% dispersed-phase volume relate to:

A. ConcentratedB. DilutedC. Highly concentratedD. W/O typeE. O/W type

84. Bacteriological inspection of disi-nfection quality at a pharmacy revealeda microorganism in an utility room (in thesink). The microorganism has the followi-ng properties: mobile nonspore-forminggram-negative bacteria that form capsularsubstance, grow well on ordinary nutrientmedia, secrete the blue-green pigment.This microorganism is most likely to beof the following genus:

A. PseudomonasB. ProteusC. ClostridiumD. ShigellaE. Vibrio

85. Microbiological analysis of medicinalraw materials revealed capsular bacteria.What stain method was used to detect thecapsules?

A. Gin’sB. Ziehl-Neelsen’sC. Neisser’sD. Gram’sE. Ozheshko’s

86. At pH value 5,0 and isoelectricpoint 4,0, the protein will migratetoward the following electrode duringelectrophoresis:

A. AnodeB. CathodeC. CalomelD. Silver chlorideE. Platinum

87. The intracellular metabolism ofglycerol starts with its activation. Whatcompound is formed as a result of the firstreaction of its conversion?

A. Alpha-glycerolophosphateB. PyruvateC. LactateD. CholineE. Acetyl coenzyme A

88. A 40-year-old patient has a history ofbronchial asthma and bradyarrhythmia.In order to eliminate bronchospasm, thedrugs of the following pharmacologicalgroup should be administered:

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A. M-anticholinergicsB. β-adrenergic blocking agentsC. M-cholinergic agentsD. Anticholinesterase agentsE. Muscle relaxants

89. Which representative of the Rosaseaefamily has spring bloom in form of whi-te, fragrant flowers gathered in pendulousracemes at the ends of short shoots?

A. Padus rasemosa (P.avia)B. Potentilla erectaC. Sorbus aucupariaD. Cerasus vulgarisE. Crataegus sanquinea

90. A patient had been diagnosed wi-th right lung cancer and administeredsurgical treatment. After right-sidedpulmonectomy the patient developed evi-dent dyspnea. What form of respiratoryfailure developed in this patient?

A. Pulmonary restrictiveB. CentralC. PeripheralD. Pulmonary obstructiveE. Thoracodiaphragmal

91. A 22-year-old male was stung by bees,the affected region became hyperemic andedematous. What is the leading mechani-sm of edema development in this patient?

A. Increased permeability of the capillariesB. Decreased hydrostatic blood pressurein the capillariesC. Increased oncotic pressure of tissuefluidD. Impaired lymphatic effluxE. Reduced oncotic pressure of blood

92. A patient has obstruction of thecommon bile duct. Which of thesesubstances is usually found in urine insuch cases?

A. BilirubinB. Ketone bodiesC. Uric acidD. CreatinineE. Glucose

93. A ground for separating lead (II)chloride from the other chlorides of theII analytical group (acid-base classificati-on) is its different solubility in:

A. Hot waterB. Hydrochloric acidC. AlkalisD. Ammonia solutionE. Sulfuric acid

94. A student analyzes an axial plantorgan characterized by radial symmetry,unlimited growth, positive geotropism. Itprovides nutrition, vegetative propagati-on, anchorage of plant in the soil. Thisorgan should be identified as:

A. RootB. StemC. LeafD. RhizomeE. Seed

95. Cross section of a root conductingzone shows pericycle that gives rise to:

A. Lateral rootsB. TrichomesC. Adventitious rootsD. Root fibrillaE. Root cap

96. Select a name that corresponds withthe formula: CH3 − C ≡ N :

A. Acetic acid nitrileB. AcetamideC. Acetic anhydrydeD. AcetoximeE. Ethyl isocyanide

97. What data is required to measure theactivation energy?

A. Constants of reaction rate at twotemperaturesB. Thermal energy of the reactionC. Energy change of the systemD. Internal energy of the systemE. Reaction order

98. A patient with chronic renal fai-lure exhibits azotemia, hypo- andisosthenuria. What is the main factor inthe pathogenesis of these symptoms in thepatient?

A. Reduction of existing nephrons massB. Increase in glomerular filtration rateC. Reduction of tubular secretionD. Disturbance of the permeability of theglomerular membraneE. Decrease in glomerular filtration rate ineach nephron

99. Which of the given compounds WILLNOT decolorize the bromine water?

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A. CH3 − CH3

B. CH2 = CH2

C. CH ≡ CHD. CH3 − CH = CH2

E.

100. Chemically, ethers are quite inertcompounds. Ethers decompose even ata room temperature under the effect ofthe following haloid acid:

A. HIB. HBrC. HClD. HFE. HClO

101. Specify the number of existingstereoisomeric aldopentoses:

A. 8B. 2C. 4D. 6E. 16

102. This scheme of nitroalkane synthesisis called the reaction of:

A. KonovalovB. ZininC. KucherovD. TishchenkoE. Chichibabin

103. A hospital admitted a patient wi-th arterial hypertension induced by renalartery stenosis. The patient complains ofpersistent nausea and headache. The mainelement in the pathogenesis of hypertensi-on is the activation of the followingsystem:

A. Renin-angiotensinB. Hypothalamic-pituitaryC. Kallikrein-kininD. SympathoadrenalE. Parasympathetic

104. The products of the toluene nitrationare mainly:

A.

B.

C.

D.

E.

105. Halogen atoms in an organiccompound can be detected by means of:

A. Beilstein testB. Molisch’s testC. Bayer’s testD. Lucas’ testE. Iodoform test

106. Before a surgical operation, asurgeon treated his hands with an alcohol-containing solution. Which group of drugsdoes this solution relate to?

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A. AntisepticsB. DisinfectantsC. Sterilizing solutionsD. DetergentsE. Surface-active substances

107. Aniline can be converted into thewater-soluble salt through the treatmentwith a solution of:

A. Hydrochloric acidB. Sodium hydroxideC. Sodium sulfateD. EthanolE. Dimethylamine

108. Select the correct product of thereaction:

A.

B.

C.

D.

E.

109. Select the formula for pentene-2 fromthe list:

A. CH3 − CH2 − CH = CH − CH3

B. CH3 − CH2 − CH2 − CH2 − CH3

C. CH3 − CH2 − CH2 − CH = CH2

D. CH3 − CH2 − CH2 − CH3

E. CH3 − CH = CH − CH3

110. Specify a compound having the mostpronounced basic properties in the gasphase:

A.

B.

C.

D. NH3

E.

111. Specify the correct name for theproduct of the acetaldehyde reacting withhydrazine:

A. Acetaldehyde hydrazoneB. Acetaldehyde oximeC. AcetaldimineD. Acetaldehyde phenylhydrazoneE. Acetaldehyde semicarbazone

112. Select a conjugated diene from the li-st of diene hydrocarbons:

A. CH2 = CH�CH = CH2

B. CH2 = C = CH�CH3

C. CH2 = CH�CH2�CH = CH2

D.

E. CH2 = CH�CH2�CH2�CH = CH2

113. Under the given conditions, theunsaturated organic compounds arereduced with the following reagent:

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A. H2, Ni, tB. HNO3, p, tC. NaOH , H2OD. K2Cr2O7, H+

E. H2O, Hg2+, H+

114. Which of the following compoundsrelates to the conjugated dienes?

A. CH3�CH2�CH = CH�CH = CH2

B. CH2 = C = CH�CH2�CH2�CH3

C. CH2 = CH�CH2�CH2�CH = CH2

D. CH3�CH = C = CH�CH2�CH3

E.

115. Which of the following solutions wi-th the same molar concentration has themaximum osmotic pressure?

A. Aluminium nitrateB. GlucoseC. Sodium chlorideD. Magnesium sulfateE. Potassium iodide

116. What class of organic compounds ischaracterized by the presence of C ≡ Ngroup?

A. NitrilesB. AminesC. Nitro compoundsD. AlcoholsE. Aldehydes

117. If the amount of a high-molecularsubstance added to the sol is very small, itmay not increase but decrease its stability.This phenomenon is called:

A. SensibilizationB. SolubilizationC. Mutual coagulationD. Colloidal protectionE. Sol habituation

118. Which medicinal plant of theAsteraceae family has only disk flowersin the flowerhead?

A. Three-part beggarticks (Bidens triparti-ta)B. Dandelion (Taraxacum officinale)C. Echinacea purpureaD. Cornflower (Centaurea cyanus)E. Common yarrow (Achillea millefolium)

119. Spore and pollen analysis revealed inthe pollen some tetrahedral spores with asemi-circular base and a reticular surface,

which may belong to:

A. LycopodiophytaB. EquisetiphytaC. BryophytaD. PolypodiophytaE. Pinophyta

120. Many species of wild rose are a sourceof vitamins, fatty oils and herbal materi-al. Specify the juicy pseudocarps that areprocured as herbal raw material:

A. Rose hipsB. CoenobiaC. HesperidesD. Aggregate-accessory fruitsE. Cenocarp stone-fruits

121. Comparison of the undergroundorgans of herbaceous plants revealed thatin the bipartite annuals the followingorgan prevails:

A. Main root systemB. Adventitious root systemC. RhizomeD. BulbE. Corm

122. Growth of some cancer cells is causedby a certain growth factor. Treatment ofleukemia involves applying an enzymethat destroys this essential factor. Speci-fy this enzyme:

A. AsparaginaseB. GlutaminaseC. Succinate dehydrogenaseD. Citrate synthaseE. Aspartate aminotransferase

123. The anti-tumor preparationMethotrexate is a structural analogue offolic acid. The mechanism of its action isbased on the inhibition of the followingenzyme:

A. Dihydrofolate reductaseB. Xanthine oxidaseC. HexokinaseD. Creatine kinaseE. Lactate dehydrogenase

124. A sample of a finished dosage formwas found to be contaminated with somemicroorganisms exhibiting the followingproperties: greenish fluorescent coloniesof gram-negative nonsporeforming bacillithat grew on the medium for the detectionof pyocyanin. The bacilli release the blue-green pigment into the medium. What mi-croorganisms contaminated the finished

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dosage form?

A. Pseudomonas aeruginosaB. EnterobacteriaceaeC. Staphylococcus aureusD. Staphylococcus epidermidisE. Staphylococcus saprophyticus

125. Vaccines are the artificial or naturalpreparations produced from bacteria, vi-ruses and other microorganisms, theirchemical components and waste products.They are used for the active immunizationof humans and animals for the preventionand treatment of infectious diseases. Theattenuated vaccines consist of:

A. Viable microbesB. Dead microbesC. AnatoxinD. Dead microbes and toxoidE. Immunoglobulins

126. What method of sterilization shouldbe used during the manufacturing liquiddosage forms containing proteins?

A. FilteringB. BoilingC. Gas sterilizationD. AutoclavingE. Pasteurization

127. Blood pressure is regulated by anumber of biologically active compounds.What peptides that enter the bloodstreamcan affect the vascular tone?

A. KininsB. LeukotrienesC. EnkephalinsD. IodothyroninesE. Endorphins

128. Addison’s (bronze) disease is treatedwith glucocorticoids. Their effect is provi-ded by the potentiation of the followingprocess:

A. GluconeogenesisB. GlycolysisC. Pentose phosphate cycleD. GlycogenolysisE. Ornithine cycle

129. Representatives of Asteraceae fami-ly have various types of flowers EXCEPTFOR:

A. BilabiateB. TubularC. FunnelformD. LigulateE. Pseudoligulate

130. Datura stramonium has dry many-seeded fruits formed by syncarpousgynoecium that dehisce when the valvesare broken off. Specify the fruit type:

A. CapsuleB. FollicleC. SiliquaD. CoenobiumE. Hesperidium

131. A sample of water used in drugproduction has been sent to a laboratoryfor sanitary and virological analysis.Presence of what virus group will be indi-cative of faecal contamination of waterand thus the need for its additional purifi-cation?

A. PicornaviridaeB. HerpesviridaeC. OrthomyxoviridaeD. RetroviridaeE. Flaviviridae

132. Specify the order of the reaction, forwhich К=1/t (1/c - 1/c0):

A. SecondB. ThirdC. FirstD. ZerothE. Fractional

133. After an insulin injection a 45-year-old female with a long history of di-abetes mellitus has developed weakness,paleness, palpitation, anxiety, double visi-on, numbness of lips and the tip of tongue.Blood glucose is at the rate of 2,5 mmol/l.What complication has developed in thepatient?

A. Hypoglycemic comaB. Hyperosmolar comaC. Hyperglycemic comaD. Hyperketonemic comaE. Uremic coma

134. A 45-year-old male patient was di-agnosed with stomach ulcer. After theconservative treatment the pain andheartburn disappeared, the function ofthe gastrointestinal tract was normali-zed. Endoscopic examination of stomachrevealed cicatrization of the ulcer. Qualifythis course of the disease:

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A. RemissionB. RelapseC. Latent periodD. RecoveryE. Prodromal stage

135. An older patient exhibits low levelsof red blood cells and hemoglobin inblood, but the color index is 1,3. Bloodsmear analysis revealed megaloblasts.What type of anemia is observed in thiscase?

A. B12-folic acid deficiencyB. Iron-deficiencyC. Acquired hemolyticD. Hereditary hemolyticE. Chronic posthemorrhagic

136. Morphological analysis of poplarinflorescence showed that it is a simplemonopodial inflorescence: main axis isdrooping, the flowers are sessile, uni-sexual. Specify the type of inflorescence:

A. CatkinB. HeadC. CapitulumD. CymeE. Panicle

137. During the morphologic analysis ofvarious plant leaves the students foundthe leaves, whose length of the leaf bladeis 5 times more than its width. Specify theshape of the leaf blade:

A. LinearB. EllipticalC. LanceolateD. OvoidE. Reniform

138. Food rich in carbohydrates at fi-rst increases the blood sugar and thendecreases its rate due to the insulin acti-on. What process is activated by thishormone?

A. Synthesis of glycogenB. GluconeogenesisC. Breakdown of glycogenD. Breakdown of proteinsE. Breakdown of lipids

139. After drinking milk a 1-year-old chi-ld developed diarrhea, flatulence. Thebaby is likely to have the deficiency ofthe following enzyme:

A. LactaseB. MaltaseC. AldolaseD. HexokinaseE. Glycosidase

140. A patient has developed megaloblasticanemia on a background of alcoholic ci-rrhosis. The main cause of anemia in thispatient is the following vitamin deficiency:

A. Folic acidB. Lipoic acidC. BiotinD. ThiaminE. Pantothenic acid

141. The fruit of black locust is dry, formedof a single carpel, dehisces by the ventraland dorsal sutures on two sides, the seedsare attached along the ventral suture. Suchfruit is called:

A. LegumeB. SiliquaC. FollicleD. CapsuleE. Silicula

142. At a chemical analytical laboratory, atechnician examines a solution of the VIanalytical group cations. After the additi-on of ammonium thiocyanate and amylalcohol, the organic layer turned blue.What cation is present in the solution?

A. Co2+

B. Ni2+

C. Cu2+

D. Hg2+

E. Cd2+

143. Microscopic study of soybean seedsstained with Sudan III revealed somedroplets of various sizes. They are:

A. LipidsB. ProteinsC. StarchD. InulinE. Glycogen

144. An analytical chemist determi-nes sodium cations by ion-exchangechromatography. In order to prepare thecation-exchange resin in the H+ form, theanalyst uses:

A. HClB. CH3COOHC. C2H5OHD. H3PO4

E. CH3OH

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145. When studying the diagnosticfeatures of Origanum vulgare, thestudents noticed that the plant had acompound monopodial inflorescence. Itis called:

A. Corymbose panicleB. Cluster of headsC. CincinnusD. BostyxE. Head

146. While preparing a solution, apharmaceutical analyst converted afreshly formed precipitate into a sol bytreating it with an electrolyte soluti-on. What method of obtaining dispersesystems was used by the analyst?

A. PeptizationB. Physical condensationC. Chemical condensationD. Solvent exchange methodE. Condensation from steam

147. Sol of iron (III) hydroxide is positi-vely charged. Specify the ion which hasthe lowest coagulation threshold:

A. SO2−4

B. Cl−

C. Cu2+

D. Na+

E. J−

148. The method of treating people withserious diseases and intoxications is basedon the absorption of toxic substances fromthe blood. What is this method called?

A. HemosorptionB. ElectrophoresisC. HemadsorptionD. DialysisE. Ultrafiltration

149. It is known that malonyl CoA isformed from acetyl CoA and carbon di-oxide under the influence of acetyl CoAcarboxylase. What vitamin is a coenzymeof this enzyme?

A. BiotinB. Folic acidC. Pantothenic acidD. AscorbateE. Thiamine

150. Specify the standard solutions thatare used in permanganatometry to quanti-fy the oxidants by the residual titrationmethod:

A. Potassium permanganate, iron (II)sulfateB. Potassium dichromate, sodium thi-osulfateC. Potassium bromate, sodium thiosulfateD. Potassium iodate, sodium thiosulfateE. Cerium (IV) sulfate, iron (II) sulfate

151. What indicator is used for fixing theendpoint of mercurimetric titration?

A. Thiocyanate complexes of iron (III)B. FluoresceinC. EosinD. MurexideE. Potassium chromate

152. Vitamin B1 deficiency has a negativeeffect on a number of processes. This iscaused by the dysfunction of the followi-ng enzyme:

A. Pyruvate dehydrogenase complexB. AminotransferaseC. Succinate dehydrogenaseD. GlutamateE. Lactate dehydrogenase

153. A patient with tuberculosis has beenprescribed some anti-TB preparations.Which of the following chemotherapeuticdrugs has an effect on the tuberculosispathogen?

A. FtivazideB. FuracilinumC. MethisazonumD. SulfadimezinumE. Phtalazolum

154. Many diseases of medicinal plants arecaused by bacteria of the Pseudomonasgenus. Select the bacteria relating to thisgenus:

A. Blue pus bacillusB. Colon bacillusC. ProteusD. MycoplasmaE. Micrococci

155. Microbiological studies of air in thepharmacy room revealed the presenceof pathogenic staphylococci. Select themedium in which you can detect thelecithinase activity of the isolated mi-croorganism:

A. Yolk-salt agarB. Blood agarC. Bismuth sulfite agarD. Sugar agarE. Meat-extract agar

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156. Colloid silver preparationsProtargolum and Collargolum are wi-dely used in medical practice as bacteri-cidal drugs. In addition to the activeingredients, these drugs contain proteincompounds. What is the function ofproteins in these preparations?

A. Prevention of coagulation of the colloi-dal solutionB. Prolongation of shelf-lifeC. Reduction of the side effectsD. Improvement of the drug technologyE. Potentiation of the bactericidal actionof silver

157. Therapeutic preparations for topi-cal use (transdermal, vaginal, etc.) do notrequire sterility. However, the total permi-ssible number of microbial cells and fungiin 1 g (ml) of a drug should not exceed:

A. 100B. 10C. 500D. 1000E. 10 0000

158. P.Ehrlich is considered to be thefounder of modern chemotherapy. Whatchemotherapy drug was developed by thisscientist?

A. SalvarsanB. SolusurminumC. CalomelD. NovarsenolumE. Osarsolum

159. A patient was admitted to a hospitalin a state of hypoglycemic coma. It occursat the following level of blood glucose:

A. 2,5 mmol/l or lessB. 4,0 mmol/lC. 3,3 mmol/lD. 4,5 mmol/lE. 5,5 mmol/l

160. A patient who had been continuouslytreated with glucocorticoids was found tohave a duodenal ulcer. What mechanismplays a major part in its development?

A. Increase of gastric juice secretion andacidityB. Acceleration of histamine inactivationin the stomachC. Inhibition of gastrin secretion in thestomachD. Excess production of prostaglandin EE. Hyperglycemia

161. To isolate the lead (II) chloride fromthe other cations of the II analytical groupin the systematic analysis, the chlorideprecipitate should be processed with:

A. Hot waterB. Ammonia solutionC. Nitric acid solutionD. Acetate acid solutionE. Alkali solution

162. What reagent is used to separatethe cations of copper (II) and mercuryfrom the other cations of the VI analyticalgroup?

A. Sodium thiosulfateB. Sodium sulfateC. Bromine waterD. Potassium sulfideE. Excess of the concentrated ammoniasolution

163. For cultivation of Brucella, purecultures should be incubated in CO2 enri-ched atmosphere. What type of breathingis typical for Brucella?

A. CapnophilicB. Facultative anaerobicC. Obligate anaerobicD. Obligate aerobicE. Any

164. Some success in reducing malariatransmission was achieved through themass destruction of transmitting mosqui-toes and their larvae. The measures aimedat the destruction of insects are called:

A. DisinfestationB. DisinfectionC. DeratizationD. SterilizationE. Decontamination

165. On the photomicrograph of aherbaceous plant stem the bicollateralvascular bundles are clearly visible. Themicrospecimen represents the stem of thefollowing plant:

A. PumpkinB. RyeC. FlaxD. CornE. Solomon’s seal

166. What type of conducting bundles istypical for all root zones of one-seededplants?

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A. RadicalB. Central phloemC. Central xylemD. BilateralE. Collateral

167. Antidepressants can increase theconcentartion of catecholamines in thesynaptic cleft. What is the mechanism ofaction of these drugs?

A. Inhibition of monoamine oxidaseB. Activation of monoamine oxidaseC. Inhibition of xanthine oxidaseD. Activation of acetylcholinesteraseE. Inhibition of acetylcholinesterase

168. The figwort family Scrophulariaceaeincludes a biennial plant up to 1,5 m hi-gh, with golden-yellow flowers gatheredin spiked inflorescences. The flowers havefive stamens. Specify this plant:

A. Verbascum flomoidesB. Digitalis purpureaC. Digitalis grandifloraD. Digitalis lanataE. Digitalis Ferruginea

169. Permanganometric titration ofhydrogen peroxide is carried out in thefollowing medium:

A. SulfateB. AlkalineC. NitrateD. HydrochloricE. Alcohol

170. Quantitative analysis of zinc saltsis performed by method of trilonometry.What indicator is used for this purpose?

A. Eriohrome black TB. PhenolphtaleinC. Methyl blackD. Potassium dichromateE. Thymol blue

171. In response to the administrationof protein drugs, a patient developed anallergic reaction. The development of theallergic reaction is caused by the increasedsynthesis of the following compound:

A. HistamineB. CholineC. AdrenalineD. HistidineE. Serotonin

172. Astragalus dasyanthus has sessileflowers gathered into inflorescences with ashort thick axis. This kind of inflorescence

is called:

A. CapitulumB. CymeC. RacemeD. HeadE. Calathidium

173. The technology of drug productionwidely uses the phenomena of absorptionand ion exchange. Which of the ions willbe selectively adsorbed on the surface ofa silver chloride crystal from an aqueoussolution?

A. Ag+

B. Cu2+

C. NO−3

D. H+

E. OH−

174. A patient with acute myocarditisexhibits rapid fatigability, shortness ofbreath, edemata of legs, hepatomegaly.Classify the type of heart failure by themechanism of its development:

A. MyocardialB. OverloadC. CompensatedD. SubcompensatedE. Combined

175. A child with PKU has an unpleasantmouse-like odor, growth retardation,mental retardation.These symptoms areassociated with the high concentration ofthe following substance in blood:

A. Phenylpyruvic acidB. GlucoseC. CholesterolD. AdrenalineE. Uric acid

176. After a contact with a person havi-ng an infectious diseases, the diseasepathogens entered the patient’s body andstarted to multiply, but the symptoms ofthe disease were not yet observable. Whatperiod of the disease is this typical for?

A. LatentB. ProdromalC. Manifest illness stageD. Clinical outcomeE. Relapse

177. Extraction is commonly usedin pharmacy for separating mixtures,increasing the concentration of any soluteand extracting lipophilic compounds fromthe herbal material. This process is based

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on:

A. Nernst distribution lawB. Konovalov’s first lawC. Dalton’s second lawD. Third law of thermodynamicsE. Hess’s Law

178. The rate of extraction of a drugsubstance depends on the value of its di-stribution coefficient. If the distributedsubstance is characterized by differentrates of dissociation or association in di-fferent phases, the distribution coefficientis calculated by:

A. Shilov-Lepin equationB. Nernst distribution lawC. Gibbs’ phase ruleD. The first Raoult’s lawE. Van’t Hoff rule

179. A male patient developed fever upto 40oC, there are vomiting, diarrhea,the patient is in grave condition. Bloodosmolality is 270 mOsm/l. What disorderof water-salt metabolism is observed inthe patient?

A. Hypoosmolar hypohydrationB. Isoosmolar hypohydrationC. Hyperosmolar hypohydrationD. Isoosmolar hyperhydrationE. Hypoosmolar hyperhydration

180. A 40-year-old male presented tothe endocrinology department with di-sproprortionate enlargement of limbs,mandible and nose. These manifestationsare caused by the overproduction of thefollowing hormone:

A. SomatostatinB. CorticotropinC. AldosteroneD. AdrenalineE. Vasopressin

181. Surfactants are commonly used inpharmaceutical production. What kind ofsurfactant is potassium oleate?

A. AnionicB. CationicC. NonionicD. AmphotericE. None of the above

182. Diabetes and starvation cause theexcess production of ketone bodies thatare used as an energy source. They areproduced from the following compound:

A. Acetyl-CoAB. IsocitrateC. LactateD. MalateE. Ketoglutarate

183. Allantoic fluid of a chicken embryocontaminated with nasopharyngeal flushof a patient was found to contain a virus.What diagnostic agents should be used toidentify it?

A. Standard antiviral seraB. Viral diagnosticumsC. Serum preparationsD. Diagnosticums produced of standardvirus strainsE. Polyvalent immune diagnostic sera

184. A patient complains of severeabdominal pain, cramps, blurred vision.His relatives exhibit the same symptoms.The urine is of red colour. The patient hasbeen hospitalized for acute intermittentporphyria. This disease might have beencaused by the impaired synthesis of thefollowing compound:

A. HemeB. InsulinC. Bile acidsD. ProstaglandinsE. Collagen

185. Common nettle, hop, blackelderberry relate to the plants that requiresoils rich in nitrogen compounds, that is,such plants are called:

A. NitrophytesB. NitrophobesC. CalciphilesD. CalciphobesE. Halophytes

186. A 40-year-old female farmworkerhas been diagnosed with brucellosis andadministered causal chemotherapy. Whatgroup of drugs will be used for thispurpose?

A. AntibioticB. Donor immunoglobulinC. Inactivated therapeutic vaccineD. Polyvalent bacteriophageE. Antitoxic serum

187. A male received a radiation dose of30 Gy. He presents with necrotic angi-na, disorders of the gastrointestinal tract.Blood tests revealed anemia, leukopeniaand thrombocytopenia. What phase ofacute radiation syndrome is observed in

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the patient?

A. Manifest illness stageB. Primary reactionsC. LatentD. Outcome of diseaseE. -

188. As a result of hypothermia amale patient developed acute diffuseglomerulonephritis. What type of allergicreaction caused damage to the glomerularcapillaries in the patient?

A. ImmunocomplexB. AnaphylacticC. CytotoxicD. Cell-mediatedE. Stimulating

189. A patient with hyperproductionof thyroid hormones has been prescri-bed Merkazolilum. This drug inhibitsthe following enzyme of iodothyroninesynthesis:

A. Iodide peroxidaseB. AromataseC. ReductaseD. DecarboxylaseE. Aminotransferase

190. A patient with Parkinson’s diseaseexhibits low level of dopamine whichis produced from dihydroxyphenylalani-ne (DOPA). What enzyme catalyzes thisconversion?

A. DecarboxylaseB. DeaminaseC. HydrolaseD. AminotransferaseE. Carboxypeptidase

191. As a result of an emergency situation(shipwreck) a man had to drink sea (salty)water. What form of water-salt imbalancemay occur in this case?

A. Hyperosmolar hyperhydrationB. Hypoosmolar hyperhydrationC. Hypotonic hyperhydrationD. Isoosmolar hyperhydrationE. Isotonic hyperhydration

192. Hemoglobin catabolism results inrelease of iron which is transported tothe bone marrow by a certain transferprotein and used again for the synthesis ofhemoglobin. Specify this transfer protein:

A. Transferrin (siderophilin)B. TranscobalaminC. HaptoglobinD. CeruloplasminE. Albumin

193. A laboratory received a food productthat had been taken from the focus offood poisoning and presumably containedbotulinum toxin. To identify the type oftoxin, the neutralization reaction must beperformed on white mice. What biologicalproduct is used in this reaction?

A. Antitoxic serumB. Normal serumC. Antibacterial serumD. DiagnosticumE. Allergen

194. For the specific prevention ofinfluenza, the employees of an enterpri-se were vaccinated with "Influvac". Whattype of immunity will develop in the bodyof the vaccinated?

A. Artificial activeB. Innate congenitalC. Artificial passiveD. Natural activeE. Natural passive

195. Suspension is a form of pharmaceuti-cals used in medical practice. Which pairof substances is able to form a suspension?

A. Water-clayB. Water-oilC. Water-ethanolD. Ethanol-ethyl acetateE. Ethanol-diethyl ether

196. In a sample studied under amicroscope the multilayer palisade(columnar) parenchyma can be clearlyseen. Such structure is typical for:

A. LeafB. RootC. Dicotyledon stemD. Rhizomes of fernsE. Adventitious roots

197. A patient exhibits small (petechial)hemorrhages under the skin and mucousmembranes, bleeding gums, tooth decay,general weakness, edemata of the lowerextremities. What vitamin deficiency canbe suspected?

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A. CB. B1

C. AD. DE. E

198. A parturient woman diagnosed wi-th uterine inertia has been delivered tothe maternity ward. The doctor gave heran injection of the drug that activatesthe contraction of smooth muscles of theuterus. What hormone is a component ofthis drug?

A. OxytocinB. GastrinC. SecretinD. AngiotensinE. Bradykinin

199. Soil microflora often includes

the representatives of pathogenic mi-croorganisms. Specify the diseases, whosecausative agents may say viable in the soilfor a long time:

A. Tetanus and gas anaerobic infectionB. Tuberculosis and mycobacteriosesC. Colibacillosis and choleraD. Leptospirosis and plagueE. Typhoid fever and dysentery

200. The one-way penetration of solventmolecules into the polymer phase resulti-ng in complete dissolution of the polymeris called:

A. Unlimited swellingB. Limited swellingC. CoacervationD. Salting-outE. Thixotropy