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Kingdom of Saudi Arabia

The National Commission for Academic Accreditation & Assessment

COURSE SPECIFICATION

Biochemistry I, 255 DMS

Revised Dec. 2011

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Course Specification Institution Jazan University College/Department : Faculty of Dentistry

A Course Identification and General Information

1 Course title and code Biochemistry I (255 DMS) 2 Credit hours 2 Credit hours (2+0+1) 3 Contact hours 3 contact hours 4 Program(s) in which the course is offered Dentistry 5 Name of faculty member responsible for the course Dr. Ayman Darwish 6 Level at which this course is offered 3rd Level 7 Year at which this course is offered Second Year

8 Pre-requisites for this course 106 PRE, 109 PRE

9 Co-requisites for this course ------ 10 Location if not on main campus Al-shawgra

B Objectives

At the end of the course the students should be able to:

1. Define the biochemistry; describe the chemical composition of humans. 2. Describe the carbohydrate, and lipid compounds found in humans. 3. Describe the general structure of fatty acid 4. To define and identify high energy bonds 5. To describe the glycogen metabolism, glycolytic pathway, citric acid cycle, hexose

monophosphate shunt, gluconeogenesis with particular stress on its regulation, and the role in metabolism

6. To describe lipid digestion 7. To depict fatty aid activation and oxidation 8. To describe fatty aid biosynthesis y fatty acid Synthase multi-enzyme complex and triglyceride

biosynthesis 9. To outline ketone body metabolism 10. To depict the structure and classes of lipoprotein

2. Plans for developing and improving the course: 1. Review and analyse collective summary of student performance of all teaching section of the

course every year. 2. Acquire feedback regarding planning for improvement of transferable skills and level of

retention of required knowledge from faculty teaching courses that demand this course as prerequisite.

C. Course Description: The course is required for all undergraduate 2nd year BDS students. This course is designed to

equip the students with necessary knowledge of biochemistry that would enable them to work with proficiency in a hospital environment.

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I. Topics to be covered

Topics No. of Weeks Introduction 1 Intermediary Metabolism 4 ½ W Integration of Metabolism 1 W Lipid Metabolism 5 ½ W

II. Course components (total contact hours per semester):

Topics No. of Weeks Date Contact hours

Introduction 1 10-9-2011 2 Intermediary Metabolism:

1) Introduction to carbohydrates 2) Digestion and absorption of carbohydrates 3) Glycogen metabolism 4) Oxidative Phosphorylation 5) Glycolysis 6) Tricarboxylic acid cycle 7) Gluconeogenesis 8) Pentose phosphate pathway and NADPH

1

½ W

1 W ½ W ½ W ½ W ½ W

17-9-2011 23-9-2011

24-9-2011 1-10-2011 1-10-2011 8-10-2011 8-10-2011

2 1

2 1 1 1 1

Integration of Metabolism 1. Insulin a. Regulation of insulin secretion b. Metabolic effects of insulin 2. Hypoglycemia and its types 3. Diabetes Mellitus 4. OBESITY To be continued after EID vacation

1 W 15-10-2011 2

TUTORIAL 1 W 22-10-2011 Lipid Metabolism

1) Introduction to Lipids 2) Lipoproteins & lipid profile 3) Cell membranes 4) Digestion and absorption of Lipids 5) Metabolism of dietary lipids 6) Fatty acid and triglyceride metabolism specially:

a. β-oxidation of fatty acids b. Ketogenesis & Ketolysis & Ketosis c. Fatty acid synthesis d. Triglyceride synthesis and catabolism and

hormonal regulation 7) Cholesterol synthesis

1 W ½ W ½ W ½ W ½ W

½ W ½ W ½ W ½ W

½ W

12-11-2011 19-11-2011 19-11-2011 19-11-2011 26-11-2011

26-11-2011 3-12-2011 3-12-2011 10-12-2011

10-12-2011

2 1 1 1 1

1 1 1 1

1 TUTORIAL 1 W 17-12-2011 2 Lecture: 26 Tutorial: 4

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3. Development of Learning Outcomes in Domains of Learning

a. Knowledge

(i) Description of the knowledge to be acquired a. At the end of the course the students should be able to understand, recall, describe(read): a) The basic processes of life in molecular terms using the cell as a unit of study. b) The normal and abnormal biochemical processes in man. c) The impact of the inherited metabolic disorders in medicine. b. At the end of the course the students should be able to integrate theoretical knowledge related

to biochemistry into clinical practice (ii) Teaching strategies to be used to develop that knowledge

1. Lectures /small group discussion to present main themes and concepts of theories. 2. Brainstorming to illustrate the differences in core concepts

(iii) Methods of assessment of knowledge acquired:

1. Multiple choice question (MCQ). 2. Matching.

b. Cognitive Skills

(i)Cognitive skills to be developed

1. Demonstrate ability to use biochemical markers of diabetes and lipid profiles on working with colleagues, family members, and teacher.

(ii) Teaching strategies to be used to develop these cognitive skills

1. Case study approach to develop rationales for diagnosis of metabolic problems.

(iii) Methods of assessment of students cognitive skills

1. MCQ (to assess and recognize the different metabolic abnormalities). 2. Scenarios or real-life simulation (to interpret/ apply psychodynamic of dentist in clinic in

presence of diabetic patient).

c. Interpersonal Skills and Responsibility

(i) Description of the interpersonal skills and capacity to carry responsibility to be developed

1. Develop awareness into one’s own attitude towards medical disorders of the dental patients.

(ii) Teaching strategies to be used to develop these skills and abilities

1. Direct interactions with students to apply and critique interpersonal skills.

d. Communication, Information Technology and Numerical Skills

(i) Description of the skills to be developed in this domain.

1. Use of web based material related to medical biochemistry of metabolism.

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(ii) Teaching strategies to be used to develop these skills

1. Group tutorial to facilitate selection & utilization of appropriate web material

(iii) Methods of assessment of students numerical and communication skills

1. Assignments (to present recent different topic related to metabolic diseases)

5. Schedule of Assessment Tasks for Students During the Semester Assessment Assessment task

(eg. essay, test, examination etc.) Week due

Proportion of Final Assessment

1 Quiz 1 5th 15% 2 Quiz 2 10th 25%

3 Activities (Seminars, assignment …. etc) ------ 10% 4 Written exam 14th 50%

D. Student Support

1. Arrangements for availability of faculty for individual student consultations and academic advice. Consultations: 2hrs/ week academic advice: 2hrs/ week E Learning Resources

1. Required Text: 1. A Textbook of Biochemistry with Clinical Correlations. T. M. Devlin, 6th Edition,

2006, Wiley- Liss publisher. ISBN 978-0-470-28173-4 1. Essential References:

1. Biochemistry: A Short Course [Deckle Edge]. John L. Tymoczko, Jeremy M. Berg, Lubert

Stryer. 2010, W. H. Freeman and Company publisher. ISBN: 0-7167-5840-7.

2. Biochemistry, Lippincott’s Illustrated Reviews. Richard Harvey & Denise Ferrier, 5th Edition,

2010, Lippincott Williams & Wilkins Publisher. ISBN: 9781609139988.

4-.Electronic Materials, Web Sites etc • Medicare web Site. • Pub med. • Sciencedirect

F. Facilities Required 1. Computing resources

1. Internet. 3. Other resources

1. PowerPoint G Course Evaluation and Improvement Processes

1 Strategies for Obtaining Student Feedback on Effectiveness of Teaching 1. Students/teacher focus groups. 2. Students' personal written reflections. 3. Students' teaching appraisal questionnaire.

2 Other Strategies for Evaluation of Teaching by the Instructor or by the Department 1. Analysis of students' performance progress through factor analysis of written periodical exams. 2. Criteria analysis of students' performance progress for practice and interpersonal skills by the

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department. 3. Peer evaluation of the instructor.

3. Processes for Improvement of Teaching 1. Continuous education for new areas that will enhance present performance. 2. Visitors of teaching experts in the field for modelling performance.

4. Processes for Verifying Standards of Student Achievement (e.g. check marking by an independent faculty member of a sample of student work, periodic exchange and remarking of a sample of assignments with a faculty member in another institution)

1. Periodic exchange and remarking of a sample of assignments with a faculty member in another institution.

2. Departmental committee to revise sample of randomly selected exams 3. Departmental revision of exam report (grade, maximum, min, average, mode and median)

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Kingdom of Saudi Arabia

The National Commission for Academic Accreditation &

Assessment

COURSE SPECIFICATION

Biochemistry II, 256 DMS

Revised Dec. 2011

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Course Specification Institution Jazan University College/Department : Faculty of Dentistry

A Course Identification and General Information

1 Course title and code Biochemistry II (256 DMS) 2 Credit hours 2 Credit hours (2+3+0) 3 Contact hours 5 contact hours 4 Program(s) in which the course is offered Dentistry 5 Name of faculty member responsible for the course Dr. Ayman Darwish 6 Level at which this course is offered 4th Level 7 Year at which this course is offered Second Year 8 Pre-requisites for this course 255 DMS 9 Co-requisites for this course ------

10 Location if not on main campus Al-shawgra

B Objectives

At the end of the course the students should be able to:

1. Describe the protein compounds found in humans. 2. Describe the general structure of amino acid 3. To define and identify protein structure, and types. 4. To describe conversion of amino acids to specialized products. 5. To describe nucleotide metabolism. 6. To show DNA structure, replication, and repair 7. To depict RNA structure, synthesis and processing 8. To describe regulation of gene expression 9. To outline the molecular basis of biotechnology and human disease 10. To have a sound knowledge on both water soluble vitamins and fat soluble vitamins, with

special emphasis on their role in metabolism and diseases caused by their deficiency. 11. To describe the role played by minerals in dentistry and medicine. 12. To describe the biochemistry of blood with special stress on blood diseases.

2. Plans for developing and improving the course: 1. Review and analyse collective summary of student performance of all teaching section of the

course every year. 2. Acquire feedback regarding planning for improvement of transferable skills and level of

retention of required knowledge from faculty teaching courses that demand this course as prerequisite.

C. Course Description: The course is required for all undergraduate 2nd year BDS students. This course is designed to

equip the students with necessary knowledge of biochemistry that would enable them to work with proficiency in a hospital environment.

III. Topics to be covered

Topics No. of Weeks Protein Structure and Function 2 W Nitrogen Metabolism 2 W Storage and Expression of Genetic Information 4 W

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Water soluble vitamins 2 W Fat soluble vitamins 1 W Minerals 1 W Blood 1 W IV. Topics to be covered

Topics No. of Weeks Date Contact

hours Protein Structure and Function

1. Amino acids structure and classifications

2. Protein structure

3. Globular protein 4. Fibrous protein 5. Enzymes

1 W ½ W ½ W ½ W 1 W

28/1/2012

4/2/2012

11/2/2012 18/2/2012

2 1 1 1 2

Nitrogen Metabolism

2. Amino Acids: Disposal of Nitrogen 3. Amino Acid Degradation and

Synthesis 4. Conversion of Amino Acids to

Specialized Products 5. Nucleotide Metabolism

½ W ½ W ½ W 1 W

25/2/2012

3/3/2012

1 1 1 2

Storage and Expression of Genetic Information

1) DNA Structure, Replication, and Repair 2) RNA Structure, Synthesis and Processing 3) Protein Synthesis 4) Regulation of Gene Expression 5) Biotechnology and Human Disease

a. Restriction Endonucleases b. DNA Cloning c. Vectors d. DNA libraries:

a) Sequencing of cloned DNA fragments

b) Probes I) Hybridization of a probe to

DNA fragments II) Synthetic oligonucleotide

probes e. Southern Blotting f. Restriction Fragment Length

Polymorphism a) Tracing chromosomes from parent to

offspring b) Prenatal diagnosis

g. Polymerase Chain Reaction h. Analysis of Gene Expression i. Gene Therapy j. Transgenic Animals

1 W ½ W 1 W ½ W ½ W ½ W ½ W

10/3/2012 17/3/2012

31/3/2012

7/4/2012

14/4/2012

2 1 2 1 1 1 1

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Water soluble vitamins 1. Vitamin B1 2. Vitamin B2 3. Niacin 4. Vitamin B6 5. Vitamin B12 6. Folic Acid 7. Biotin 8. Vitamin C

½ W ½ W ½ W ½ W

21/4/2012

28/4/2012

1 1 1 1

Fat soluble vitamins

1. Vitamin A 2. Vitamin D 3. Vitamin K 4. Vitamin E

½ W ½ W

5/5/2012

1 1

Minerals

1. Calcium 2. Phosphorus 3. Sodium 4. Potassium 5. Fluorine

½ W ½ W

12/5/2012

1 1

Blood

1. Haemoglobin structure 2. Haem structure and synthesis 3. Types of normal haemoglobin 4. Types of abnormal haemoglobin 5. Porphyrias 6. Jaundice 7. Sickle cell anaemia. 8. Thalassemia

½ W ½ W

19/5/2012

1 1

# Practical Topic Week 1 Colorimetry

2nd W

2 Serum Glucose

3rd W

3 Oral Glucose Tolerance Test

4th W

4 Colorimetric Estimation of Cholesterol in the serum 5th W 5 Colorimetric Estimation of Triglycerides in the serum 6th W 6 Creatinine Clearance Test

7th W

7 Colorimetric Estimation of urea in plasma

8th W

8 Colorimetric estimation of uric acid in plasma

9th W

9 Colorimetric estimation of serum proteins

10th W

10 Colorimetric estimation of bilirubin in plasma 11th W 11 Revision 12th W 12 Exam 13th W

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3. Development of Learning Outcomes in Domains of Learning

a. Knowledge

1) Description of the knowledge to be acquired a. At the end of the course the students should be able to understand, recall, describe(read): a) The basic processes of life in molecular terms using the cell as a unit of study. b) The normal and abnormal biochemical processes in man. c) The impact of the inherited metabolic disorders in medicine. b. At the end of the course the students should be able to integrate theoretical knowledge

related to biochemistry into clinical practice 2) Teaching strategies to be used to develop that knowledge

1. Lectures /small group discussion to present main themes and concepts of theories. 2. Brainstorming to illustrate the differences in core concepts

3) Methods of assessment of knowledge acquired:

1. Multiple choice question (MCQ). 2. Matching.

b. Cognitive Skills

(i)Cognitive skills to be developed

1. Demonstrate ability to use biochemical markers of protein, nucleic acids, blood, vitamins, minerals on working with colleagues, family members, and teacher.

(ii) Teaching strategies to be used to develop these cognitive skills

1. Case study approach to develop rationales for diagnosis of blood and minerals problems.

(iii) Methods of assessment of students cognitive skills : MCQ

c. Interpersonal Skills and Responsibility

(i) Description of the interpersonal skills and capacity to carry responsibility to be developed:

Develop awareness into one’s own attitude towards medical disorders of the dental patients.

(ii) Teaching strategies to be used to develop these skills and abilities: by Direct interactions with students to apply and critique interpersonal skills.

d. Communication, Information Technology and Numerical Skills

(i) Description of the skills to be developed in this domain: by Use of web based material related to medical biochemistry of metabolism.

(ii) Teaching strategies to be used to develop these skills: by Group tutorial to facilitate selection & utilization of appropriate web material

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5. Schedule of Assessment Tasks for Students During the Semester Assessment Assessment task

(eg. essay, test, examination etc.) Week due

Proportion of Final Assessment

1 Quiz 1 5th 5% 2 Mid-term exam 7th 20% 3 Quiz 2 10th 5% 4 Practical 14th 10% 5 Activities (Seminars, assignment …. etc) ------ 10% 6 Written exam 15th 50%

D. Student Support

1. Arrangements for availability of faculty for individual student consultations and academic advice. Consultations: 2hrs/ week academic advice: 2hrs/ week E Learning Resources

1. Required Text: A Textbook of Biochemistry with Clinical Correlations. T. M. Devlin, 6th Edition, 2006, Wiley- Liss publisher. ISBN 978-0-470-28173-4

2. Essential References: 1) Biochemistry: A Short Course [Deckle Edge]. John L. Tymoczko, Jeremy M. Berg, Lubert

Stryer. 2010, W. H. Freeman and Company publisher. ISBN: 0-7167-5840-7. 2) Biochemistry, Lippincott’s Illustrated Reviews. Richard Harvey & Denise Ferrier, 5th Edition,

2010, Lippincott Williams & Wilkins Publisher. ISBN: 9781609139988.

3. Electronic Materials, Web Sites etc • Medicare web Site. • Pub med. • Sciencedirect

F. Facilities Required 1. Computing resources as internet. 2. Other resources as PowerPoint

G Course Evaluation and Improvement Processes 1 Strategies for Obtaining Student Feedback on Effectiveness of Teaching

1) Students/teacher focus groups. 2) Students' personal written reflections. 3) Students' teaching appraisal questionnaire.

2 Other Strategies for Evaluation of Teaching by the Instructor or by the Department 1) Analysis of students' performance progress through factor analysis of written periodical exams. 2) Criteria analysis of students' performance progress for practice and interpersonal skills by the

department. 3) Peer evaluation of the instructor.

3. Processes for Improvement of Teaching 1) Continuous education for new areas that will enhance present performance. 2) Visitors of teaching experts in the field for modelling performance.

12

4. Processes for Verifying Standards of Student Achievement (e.g. check marking by an independent faculty member of a sample of student work, periodic exchange and remarking of a sample of assignments with a faculty member in another institution)

1) Periodic exchange and remarking of a sample of assignments with a faculty member in another institution.

2) Departmental committee to revise sample of randomly selected exams 3) Departmental revision of exam report (grade, maximum, min, average, mode and median)