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For information on how to contribute to the Gene Wiki at Wikipedia, please see Portal:Gene Wiki.

The Gene Wiki is a project that facilitates transferring information on human genes to Wikipedia article stubs with the goal of promoting collaboration and expansion of the articles.[1][2][3]

Contents

1 Project goals and scope 1.1 Number of gene articles 1.2 Expansion 1.3 Proteins encoded by genes 2 Gene Wiki generated content 3 See also 4 References 5 Further reading 6 External links

Project goals and scopeNumber of gene articles

The human genome contains an estimated 20,000�25,000 protein-coding genes.[4] The goal of the Gene Wiki project is to create seed articles for every notable human gene, that is, every gene whose function has been assigned in the peer-reviewed scientific literature. Approximately half of human genes have assigned function, therefore the total number of articles seeded by the Gene Wiki project would be expected to be in the range of 10,000 - 15,000. To date, approximately 11,000 articles have been created or augmented to include Gene Wiki project content.[5]Expansion

Once seed articles have been established, the hope and expectation is that these will be annotated and expanded by editors ranging in experience from the lay audience to students to professionals and academics.[1]Proteins encoded by genes

The majority of genes encode proteins hence understanding the function of a gene generally requires understanding of the function of the corresponding protein. In addition to including basic information about the gene, the project therefore also includes information about the protein encoded by the gene.Gene Wiki generated content

Stubs for the Gene Wiki project are created by a bot and contain links to the following primary gene/protein databases:

HUGO Gene Nomenclature Committee � official gene name Entrez � Gene database OMIM (Mendelian Inheritance in Man) � database that catalogues all the known diseases with a genetic component Amigo � Gene Ontology HomoloGene � gene homologs in other species SymAtlasRNA � gene expression pattern in tissues[6] Protein Data Bank � 3D structure of protein encoded by the gene UniProt (universal protein resource) � a central repository of protein data

See also

Portal:Gene Wiki/Other Wikis � a list of Gene Wikis external to Wikipedia

References

Huss JW, Orozco C, Goodale J, Wu C, Batalov S, Vickers TJ, Valafar F, Su AI (July 2008). "A Gene Wiki for Community Annotation of Gene Function". PLoS Biol. 6 (7): e175. doi:10.1371/journal.pbio.0060175. PMC 2443188. PMID 18613750.Huss JW, Orozco C, Goodale J, Wu C, Batalov S, Vickers TJ, Valafar F, Su AI. "SciVee Pubcast: A Gene Wiki for Community Annotation of Gene Function". Retrieved 2008-11-19.Huss JW; Lindenbaum P; Martone M; et al. (January 2010). "The Gene Wiki: community intelligence applied to human gene annotation". Nucleic Acids Res. 38 (Database issue): D633�9. doi:10.1093/nar/gkp760. PMC 2808918. PMID 19755503.Clamp M, Fry B, Kamal M, Xie X, Cuff J, Lin MF, Kellis M, Lindblad-Toh K, Lander ES (December 2007). "Distinguishing protein-coding and noncoding genes in the human genome". Proc. Natl. Acad. Sci. U.S.A. 104 (49): 19428�33. doi:10.1073/pnas.0709013104. PMC 2148306. PMID 18040051."Gene Wiki Pages". Pages that link to {{PBB}}. Wikipedia, the free encyclopedia. Retrieved 2015-01-27.

Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, Cooke MP, Walker JR, Hogenesch JB (April 2004). "A gene atlas of the mouse and human protein-encoding transcriptomes". Proc. Natl. Acad. Sci. U.S.A. 101 (16): 6062�7. doi:10.1073/pnas.0400782101. PMC 395923. PMID 15075390.

Further reading

Good BM, Howe DG, Lin SM, Kibbe WA, Su AI (2011). "Mining the Gene Wiki for functional genomic knowledge". BMC Genomics 12: 603. doi:10.1186/1471-2164-12-603. PMC 3271090. PMID 22165947. Good BM, Clarke EL, de Alfaro L, Su AI (January 2012). "The Gene Wiki in 2011: community intelligence applied to human gene annotation". Nucleic Acids Res. 40 (Database issue): D1255�61. doi:10.1093/nar/gkr925. PMC 3245148. PMID 22075991. Good BM, Clarke EL, Loguercio S, Su AI (2012). "Linking genes to diseases with a SNPedia-Gene Wiki mashup". J Biomed Semantics. 3 Suppl 1: S6. doi:10.1186/2041-1480-3-S1-S6. PMC 3337266. PMID 22541597. Su AI, Good BM, van Wijnen AJ (December 2013). "Gene Wiki Reviews: marrying crowdsourcing with traditional peer review". Gene 531 (2): 125. doi:10.1016/j.gene.2013.08.093. PMID 24012870.

External links

Spagat E (2008-07-09). ": Edit your DNA: `Gene wiki' to debut on Wikipedia". The Associated Press (in ABC News. Retrieved 2011-09-29. McKenney AS (2008-07-08). "Archiving Information About The Human Genome Using Wikipedia". IT / Internet / E-mail News. Medical News Today. Retrieved 2008-07-19. Tay L (2008-07-10). "Wikipedia hosts human gene repository". iTnews Australia. Haymarket Media. Retrieved 2008-07-19. Mitch Waldrop (3 September 2008). "Big data: Wikiomics". Nature. pp. 22�25.