Junyu Ma, Ph.D Curriculum Vitae

Columbus, OH 43202

junyuma@gmail.com

(803)-586-2871

•Over 10 years solid professional experience in cell culture, target drug delivery and cancer diagnosis device development• In-depth knowledge of using principle of cell biology, molecular biology, materials science and engineering to solve biotechnology problems • Excellent hands on skills of cell culture, cell based assay, polymer synthesis, drug loaded nanoparticle preparation and medical device fabrication• Strong analytical, problem solving and multitasking skills coupled with ability to work both independently and as part of a multidisciplinary team• Eligible to working for any employers in USA without sponsorship

Results-oriented and self-motivated biomedical engineering professional seeking R&D position in Biotech/Medical Device industry

Objective

Key Qualifications

Education

1999~2003

2003~06

2006~2011

B.S. in Life Sciences, University of Science and Technology of China

M.S. in Biochemical Engineering, Dalian Institute of Chemical Physics. P.R. China

Ph.D. in Chemical Engineering, University of South Carolina, Columbia, SC

Technical SkillsCell Biology Techniques:

mammalian and bacteria cell culture, cell-based toxicity test, bacteria transformation, cell transfection, flow cytometry, fluorescent microscopy, confocal microscopy

Immunology Techniques:

immunostaining, ELISA development

Molecular Biology Techniques:

RNA and DNA Extraction, PCR, DNA Gel Analysis, Western Blotting

Animal Manipulation:

handling and breeding, primary cells generation, injection, blood withdrawal, survival surgery and post-operative care of rodents

Analytical Techniques:

GPC, HPLC, LC-MS, NMR, SEM, spectrophotometry

Professional ExperiencePostdoctoral Researcher, The Ohio State University, Department of Chemical& Biomolecular Engineering May 2011-present

• Develop a non-invasive detection method, tethered cationic lipoplex nanoparticles biochip, to simultaneously captures and characterize tumor biomarkers such as circulating tumors cells

and exosomes.• Successfully generated induced neuron from embryonic and adult

fibroblast cells with nonviral method, achieving low tumorgenicity and mutation compared with traditional viral method • Fabricated a multifunctional device by combining release chamber

and cell microencapsulation for therapeutic and pharmaceutics applications, such as treating diabetics and monitoring inflammation

• Develop a non-invasive detection method, tethered cationic lipoplex nanoparticles biochip, to simultaneously captures and characterize tumor biomarkers such as circulating tumors cells

and exosomes.• Successfully generated induced neuron from embryonic and adult

fibroblast cells with nonviral method, achieving low tumorgenicity and mutation compared with traditional viral method • Fabricated a multifunctional device by combining release chamber

and cell microencapsulation for therapeutic and pharmaceutics applications, such as treating diabetics and monitoring inflammation

Professional ExperienceResearch Assistant August 2006-May 2011University of South Carolina, Department of Chemical Engineering“Tissue engineered bone regeneration in a biodegradable osteoinductive scaffold”

• Studied methods for synthesis of complex organic molecules, such as macromers and peptides

• Implemented chemical variations to polymers to introduce functionality• Studied techniques for culture, differentiation, and analysis of bone marrow stromal cells• Characterized the biocompatibility and osteogenic potential of scaffolds in vivo

(subcutaneous implantation, critical femoral defect of rats, and others )

 “

“Tissue engineered bone regeneration in a biodegradable osteoinductive scaffold”• Studied methods for synthesis of complex organic molecules, such as macromers and

peptides• Implemented chemical variations to polymers to introduce functionality• Studied techniques for culture, differentiation, and analysis of bone marrow stromal cells• Characterized the biocompatibility and osteogenic potential of scaffolds in vivo

(subcutaneous implantation, critical femoral defect of rats, and others )

 “

Professional ExperienceResearch Assistant August 2006-May 2011University of South Carolina, Department of Chemical Engineering

“Multi-functional nanoparticles for drug delivery in vitro and in vivo study”• Conjugated and encapsulated rhBMP-2 in NPs for differentiation of bone marrow

stromal cells• Encapsulated Paclitaxel in biodegradable self-assembled core-shell poly(lactide-co-

glycolide ethylene oxide fumarate) nanoparticles for targeted anti-tumor drug delivery

 “

“Multi-functional nanoparticles for drug delivery in vitro and in vivo study”• Conjugated and encapsulated rhBMP-2 in NPs for differentiation of bone marrow

stromal cells• Encapsulated Paclitaxel in biodegradable self-assembled core-shell poly(lactide-co-

glycolide ethylene oxide fumarate) nanoparticles for targeted anti-tumor drug delivery

 “

Professional ExperienceResearch Assistant August 2003- May 2006Dalian Institute of Chemical Physics

• Fabricated artificial pancreas based on cell microencapsulation technology to treat diabetes

• Transplanted alginate-chitosan-alginate microencapsulated bovine chromaffin cells to mice intraperitoneal cavity, achieving long term analgesic effect

• Immobilized endostatin secreting CHO cells in microcapsules and optimized production of endostatin in bioreactors

• Fabricated artificial pancreas based on cell microencapsulation technology to treat diabetes

• Transplanted alginate-chitosan-alginate microencapsulated bovine chromaffin cells to mice intraperitoneal cavity, achieving long term analgesic effect

• Immobilized endostatin secreting CHO cells in microcapsules and optimized production of endostatin in bioreactors

Publications• 1. J. Ma, X. He, E. Jabbari. “Osteogenic Differentiation of Marrow Stromal Cells on Random and Aligned

Electrospun Poly(L-lactide) Nanofibers”. Annals of Biomedical Engineering. 2011, 39(1): 14-25• 2. X. He, J. Ma, E. Jabbari. “Migration of marrow stromal cells in response to sustained release of stromal-

derived factor-1α from poly(lactide ethylene oxide fumarate) hydrogels”. International Journal of Pharmaceutics. 2010, 390(2):107-116

• 3. W. Xu, J. Ma, X. He, E. Jabbari. “Material properties and osteogenic differentiation of marrow stromal cells on fiber-reinforced laminated hydrogel nanocomposites”. Acta Biomaterialia. 2010, 6(6):1992-2002

• 4. A.E. Mercado, J. Ma, X. He, E. Jabbari. “Release characteristics and osteogenic activity of recombinant human bone morphogenetic protein-2 grafted to novel self-assembled poly(lactide-co-glycolide fumarate) nanoparticles”. J. Control. Release. 2009, 140: 148-156.

• 5. X. He, J. Ma, A. E. Mercado, W. Xu, E. Jabbari. “Cytotoxicity of Paclitaxel in Biodegradable Self-Assembled Core-Shell Poly(Lactide-Co-Glycolide Ethylene Oxide Fumarate) Nanoparticles”. Pharm. Res. 2008, 25(7):1552-1562.

• 6. X. He, J. Ma, E. Jabbari. “Effect of grafting RGD and BMP-2 protein-derived peptides to a hydrogel substrate on osteogenic differentiation of marrow stromal cells”. Langmuir. 2008, 24 (21): 12508–12516

• 7. S. Moeinzadeh, S. Khorasani, J. Ma, X. He, E. Jabbar. “Synthesis and gelation characteristics of photo-crosslinkable star Poly(ethylene oxide-co-lactide-glycolide acrylate) macromonomers”. Polymer. 2011,52(18): 3887–3896

• 8. J. Zhou, Y. Zhang, W. Wang, J. Ma, H. Zhang, X. Guo, X. Ma. “The Effect of Glutamine on the Growth, Metabolism and Endostatin Production of Microencapsulated rCHO Cells”. Chinese Journal of Biotechnology.2006, 22(1): 162-166