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John Chant, a postdoctoral fellow in the laboratory of John Pringle (University of North Carolina,Chapel Hill) will visit Hsiao-Ping Moore's laboratory at the University of California, Berkeley.

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The Extracellular Matrix of Plants: Molecular,Cellular and Developmental BiologyOrganizers: L Andrew Staehelin, PeterAlbersheim, Keith Roberts and Alan G. DarvillJanuary 9-15,1993; Santa Fe, New Mexico

Protein Purification and BiochemicalEngineeringOrganizers: William Drohan, Patrick LColeman and Richard R. BurgessJanuary 15-21, 1993; Santa Fe, New Mexico

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Pbosphorylation/Dephasphorylation inSignal TransductionOrganizers: Mariano Barbacid andJoseph B. BolenJanuary 17-24,1993; Keystone, Colorado

Cell Adhesion Mechanisms inLeukocyte TrafficOrganizer: Michael GallatinJanuary 24-31, 1993; Keystone, Colorado

Carbohydrate Uganda and Their ProteinReceptors: Biological Function andMolecular InteractionOrganizer: Roger A. LaineJanuary 24-31,1993; Keystone, Colorado

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Cytokines and Cytokine Receptors:From Cloning to the ClinicOrganizers: Steven Gillis and James WatsonJanuary 31-February 7, 1993; Keystone, Colorado

Molecular Mechanisms in RheumatoidArthritis and Related DiseasesOrganizers: William P. Arend andWilliam J. KoopmanJanuary 31-February 7, 1993; Keystone, Colorado

B Cell Immunobiology and Human DiseaseOrganizers: Rainer F. Storb, Carol Nottenburgand Edward ClarkFebruary 1-8, 1993; Taos, New Mexico

Molecular Aspects of B LymphocyteDifferentiationOrganizers: Randolph Wall and Paul KincadeFebruary 1-8, 1993; Taos, New Mexico

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Genetic and In Vitro Analysis of CellCompartmentalize tionOrganizer: David MeyerFebruary 8-14, 1993; Taos, New Mexico

Emerging Principles for Vaccine Development:Antigen Processing and PresentationOrganizer: Per A. PetersonFebruary 8-14,1993; Taos, New Mexico

Molecular Helminthology:An Integrated ApproachOrganizers: James Bennett, Timothy G. Geary,Roger K. Prichard, Phil Lo Verde, Fritz Rottman andSam WardFebruary 10-17, 1993; Tamarron, Colorado

Molecular Genetic Controls of MicrobialDifferentiationOrganizers: William £ Tlmberlake andRichard LosickFebruary 17-23,1993; Tamarron, Colorado

Nucleases: Structure, Function andBiological RolesOrganizers: R Stephen Lloyd, Stuart Unn andRichard J. RobertsFebruary 23-March 1, 1993; Tamarron, Colorado

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Molecular Biology of Neuronal SignalTransductionOrganizers: Tom Curfan, Moses V. Chao,James I. Morgan and Thomas L SchwarzMarch 24-31, 1993; Taos, New Mexico

Frontiers in HTV PathogenesisOrganizers: Margaret I. Johnston andDavid D. HoMarch 29-April 4, 1993; Keystone, Colorado

Progress in Basic Research of WoundRepair and its Application to ClinicalManagement of Problematic WoundsOrganizers: John M. McPherson andRichard A. ClarkMarch 29-April 4, 1993; Breckenridge, Colorado

Extracellular Matrix in Developmentand DiseaseOrganizer: A. Harri ReddiMarch 29-April 4, 1993; Breckenridge, Colorado

Genetically Targeted Research &Therapeutics: Antisense & Gene TherapyOrganizers: James W. Hawkins andW. French AndersonApril 12-18, 1993; Keystone, Colorado

Gene TherapyOrganizers: Richard C. Mulligan, Inder Vermaand David HausmanApril 12-18, 1993; Keystone, Colorado

B and T Cell LymphomasOrganizers: James Armitage, Thomas Waldmann,Franco Cavalli and Robert Peter GaleApril 17-24, 1993; Copper Mountain, Colorado

Transposition and Site-Specific Recombination:Mechanism and BiologyPOSTPONED

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Some Forthcoming ArticlesThe origin of P elements In Drosophlla melanogaster

by William R. EngelsAlzheimer's Disease untangled by Fiona Crawford and Alison

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and John P. MerlieThe molecular cell biology of anlon transport by bacteria by

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The size* of mitochondria] genomes In higher plants ire known to range from 200 to 2400 kilobtse pom(kbp, WanietaL 1981). However, bcc*u«cof the detectloo by eJectroo micro«ropy of much mailer ml-DNA molecule* (•pproximnety 30 kbp) tban would be expected from the nzt of the fcnoaic (SparVi todD«le, 19S0;Wo^aulWTklnwn, 1972), the large ilzra of tfae nM-fewma of Mjher piam* ta«vc becoattributed Co heterogeneity of the nH-DNA moleculei On the ba l l of tfae phyiicaJ maps of mt-DNAfroinBramca (Palmer and SdueJd, 1964 )u*d maize (LomdikctaL I9S4), tt h«s been pnjposcd th« theseirrodl mt-DNA rookaruka arc derived from ooe Urge, circuiw molecule called the 'muter generatecircle" of 218 t bpbBm»ka ind 570 kbp brmiic. By contimC tt hti been reyeaJed by conveotkmiiraicnacopy combiocd with pbotoruetry that cacfa mitocboodrkn iquuhed out tvom cells of AUktra cepaand Nltella flejdUi conalni one ml-oucleus, and the Intensity of the flDorescence from each mt-nucteut tsBpproxliaaKty40%(T0kbp)oftha(ofT4pboge(l70tbp, Kurolw*, l9S2,Nbh£btyasbiet aL I9S7).Tberef ore, there appean to be a diicTepoucy between the tarae size of me mitocnoadriaJ gcoomc and thetmaJI amount of DNA per Indivlduaj mltocnondfion.

Table 1. Percentage of orgam of various type] In tfaeflnt wboti poritions of ap2 mutantsOeootype(oo of fktwers icored)

QFSROLKP rSUIQATDTS Q H U m j O n OTDgADLVHaVTUUtTUCPQUIETtEKMl*# * * # * * #* * * * ** * * * * * * * * * * * * *

QFTHtOLM EKXLOASDHN O R i T T L I Q n OVCQABXVPSSVMIEKIPIUIVIHFTXERI142

2WmmDKKTVHURVmrLKWHOTIBSmTHBPHHinJBCPHLIAErmUOl'HEHliBCPELIAErSH

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ContentsVolume 103 (2) 1992

CommentariesUnderhill, C.CD44: The hyaluronan receptor 293-298

Can-away, K. L., Fregien, N., Carraway, K. L. Ill andCarraway, C. A. C.Tumor sialomucin complexes as tumorantigens andmodulators of cellular interactions and proliferation 299-307

Henson, J. H., Nesbitt, D., Wright, B. D. and Scholey, J. M.Immunolocalization of kinesin in sea urchin coelomocytes:Association of kinesin with intracellular organelles 309-320

Lahtinen, U., Dahilof, B. and Saraste, J.Characterization of a 58 kDa cis-Golgi protein in pancreaticexocrine cells 321-333

Parton, R. GM Schrotz, P., Bucci, C. and Gruenberg, J.Plasticity of early endosomes 335-348

Shih, S.-J. and Nelson, D. L.Proteolytic processing of secretory proteins in Paramecium:immunological and biochemical characterization of theprecursors of tnchocyst matrix proteins 349-361

Brodsky, V. Y., Bolkov, P. Y., Nechaeva, N. V.,Yurovitsky, Y. G., Novikova, T. E., Fateeva, V. I. andSchevchenko, N. A.The rhythm of protein synthesis does not depend onoscillations of ATP level 363-370

CoukeU, M. B., Cameron, A. M. and Adames, N. ItInvolvement of intracellular calcium in protein secretion inDictyostelium discoidcum 371 -380

Warren, S. L., Landolfi, A. S., Curtis, C. and Morrow, J. S.Cytostellm: a novel, highly conserved protein that undergoescontinuous redistribution during the cell cycle 381 -388

Vincent, C , Cheek, T. R. and Johnson, M. H.Cell cycle progression of parthenogenetically activated mouseoocytes to mterphase is dependent on the level of internalcalcium 389-396

Katsuta, J. and Shibaoka, H.Inhibition by kinase inhibitors of the development and thedisappearance of the preprophase band of microtubules intobacco BY-2 cells 397^105

McNulty, A. K. and Saunders, M. J.Purification and immunological detection of pea nuclearintermediate filaments: evidence for plant nuclear lamins 407-414

Jenkins, G. and Okumus, A.Indiscriminate synapsis in achiasmate Alliumfistulosum L.(Liliaceae) 415-422

Mardon, H. J. and Sebastio, G.Regulation of alternative splicing in the IIICS region of humanfibronectin pre-mRNA encoding cell binding sites CS1 andCS5 423-433

Aplin, J. D., Sattar, A. and Mould, A. P.Variant chonocarcinoma (BeWo) cells that differ in adhesionand migration on fibronectin display conserved patterns ofintegrin expression 435.444

Kielty, C. M., Whittaker, S. P., Grant, M. E. andShuttleworth, C A.Attachment of human vascular smooth muscle cells to intactmicrofibrillar assemblies of collagen VI and fibrillin 445-451

Swinscoe, J. C. and Carlson, E, C.Capillary endothelial cells secrete a heparin-binding mitogenforpericytes 453-461

Bogner, P., Skehan, P., Kenney, S., Salnz, E. andFriedman, S. J.Stabilization of intercellular contacts in MDCK cells duringCa2+ deprivation. Selective effects of monocarboxylic acidson desmosomes 463-473

RlddcUe, K. S., Hopkinson, S. B. and Jones, J. C. R.Hemidesmosomes in the epithelial cell line 804G: their fateduring wound closure, mitosis and drug inducedreorganization of the cytoskeleton 475-490

Truskey, G. A., Burmeister, J. S., Grapa, E. and Relchert,W.M.Total internal reflection fluorescence microscopy (TTRFM). II.Topographical mapping of relative cell/ substratum separationdistances 491-499

Grunt, Th. W., Somay, C , Oeller, H., Dlttrich, E. andDittrich,Ch.Comparative analysis of the effects of dimethyl sulfoxide andretinoic acid on the antigenic pattern of human ovarianadenocarcinoma cells 501-509

Fukamachi, H.Proliferation and differentiation of fetal rat intestinal epithelialcells in primary serum-free culture 511-519

Arciniegas, E., Sutton, A. B., EUen, T. D. and Schor, A. M.Transforming growth factor beta 1 promotes thedifferentiation of endothelial cells into smooth muscle-likecells in vitro 521-529

Gherardi, E^ Thomas, K^ Le Cras, T. D., Fitzsimmons, C ,Moorby, C. D. and Bowyer, D. E.Growth requirements and expression of LDL receptor andHMG-CoA reductase in Hep G2 hepatoblastoma cellscultured in a chemically defined medium 531-539

Moorby, C. D., Gherardi, E., Riddell, D. and Bowyer, D. E.Porcine smooth muscle cell-conditioned medium stimulatesLDL receptor activity in Hep G2 cells 541-549

Peng, H. B. and Chen, Q.Induction of dystrophin localization in cultured Xenopusmuscle cells by latex beads 551-563

Leick,V.Chemotactic properties, cellular binding and uptake ofpeptides and peptide derivatives: Studies with Tetrahymenathermophila 565-570

Fawcett, J. W., Fersht, N., Housden, L., Schachner, M. andPesbeva, P.Axonal growth on astrocytes is not inhibited byoligodendrocytes 571-579

Barofflo, A. and Blot, M.Statistical evidence for a random commitment of pluripotentcephalic neural crest cells 581-587

Dahlstrand, J., Zimmerman, L. B., McKay, R. D. G. andLendahl.U.Characterization of the human nestin gene reveals a closeevolutionary relationship to neurofilaments 589-597

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