introduction to clinical epidemiology hui jin department of epidemiology and health statistics...
TRANSCRIPT
![Page 1: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/1.jpg)
Introduction to clinical epidemiology
Hui JinDepartment of Epidemiology and Health StatisticsSchool of Public HealthSoutheast University Email: [email protected]
![Page 2: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/2.jpg)
Key content
• Definition of epidemiology• Definition of clinical epidemiology• The purpose of epidemiology• The use of epidemiology• The types of epidemiology
• What-why-where-when-which
![Page 3: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/3.jpg)
Increasing demands on their time are squeezing out opportunities to stay abreast of the literature, much less read it critically. Results of several studies indicate an inverse relation between knowledge of contemporary care and time since graduation from medical school. In many jurisdictions, attendance at a specified number of hours of continuing medical education courses is mandatory to maintain a licence to practise. However, the failure of these courses to improve patient care emphasises the importance of selfdirected learning through reading. Many clinicians in practice, though, report that they feel unqualified to read the medical literature critically.
Scientific illiteracy is a major failing of medical education.
Clinicians today are in a bind.
Grimes DA, Schulz KF. An overview of clinical research: the lay of the land. Lancet 2002; 359:57-61.
![Page 4: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/4.jpg)
Field of Medicine
• Basic medicine ----cell,• Clinical medicine ---organ, system, person• Population medicine ---public health
![Page 5: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/5.jpg)
• Public health is "the science and art of preventing disease, prolonging life and promoting health through the organized efforts and informed choices of society, organizations, public and private, communities and individuals.“
2 distinct characteristics: preventive rather than curative
population-level rather than individual-level
![Page 6: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/6.jpg)
Quantitative Methods
• Epidemiology and biostatistics are the basic sciences of public health, as quantitative methods in Public health investigations
• Epidemiology is about the understanding of disease development and the methods used to uncover the etiology, progression, and treatment of the disease
• Information (data) is collected to investigate a question
• The methods and tools of biostatistics are used to analyze the data to aid decision making
![Page 7: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/7.jpg)
What is Epidemiology?What is Epidemiology?
![Page 8: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/8.jpg)
• Epidemiology is the study of the distribution and determinants of health-related states or events in specified populations, and the application of this study to control of health problems
![Page 9: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/9.jpg)
Disease
Distribution of people, place and time
Risk factors
Such as, smoking, exercise, fatty foods,
stress
Such as, heart disease, a felling of well-being,
lung cancer
Such as, Men 25-40, children, 7 out of 10 women
What is Epidemiology?What is Epidemiology?
![Page 10: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/10.jpg)
THE THREE ESSENTIAL CHARACTERISTICS OF DISEASE WE LOOK FOR :
• TIME• PLACE• PERSON
![Page 11: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/11.jpg)
TimeTime
• Changing or stable?
• Seasonal variation.
• Clustered (epidemic) or evenly distributed (endemic)?
• Point source or propagated.
![Page 12: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/12.jpg)
TimeTime
![Page 13: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/13.jpg)
TimeTime
![Page 14: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/14.jpg)
14
a single point source exposure mode
![Page 15: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/15.jpg)
15
Multi-points spread - human-to-human transmission mode
![Page 16: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/16.jpg)
PlacePlace
• Geographically restricted or widespread (pandemic)?
• Relation to water or food
supply. • Multiple clusters or one?
![Page 17: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/17.jpg)
PlacePlace
![Page 18: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/18.jpg)
PlacePlace
![Page 19: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/19.jpg)
PersonPerson• Age
• Socio-economic status
• Gender
• Ethnicity/Race
• Behavior
![Page 20: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/20.jpg)
Some famous examples in the history of Epidemiology
![Page 21: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/21.jpg)
John Snow- 1830’s cholera epidemic spread from
Asia, >60,000 deaths
- New epidemic 1850’s ~ Great Britain
- John Snow, plotted location of deaths in London
- Postulated association between deaths & provision of water
Photo source of color image: Sukon KanchanaraksaPhoto source of portrait: http://www.ph.ucla.edu/epi/snow/fatherofepidemiology.html. Public Domain
![Page 22: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/22.jpg)
Snow’s Cholera Map, 1854
![Page 23: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/23.jpg)
Cholera example Water Population Deaths from Supplier 1851
Cholera Rate*
•Southwark 167,654 844 5.0& Vauxhall
•Lambeth 19,133 18 0.9
•Both 300,149 652 2.2
*Death rate per 1000
![Page 24: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/24.jpg)
20th CenturySmoking & lung cancer
- Increase in lung cancer deaths in 1940s (x 6 within 30 years) published in BMJ
- Postulated cause?
- Doll & Hill published a case-control study (1950) – smokers at higher risk (interviews with hospitalised men)
- Study design criticised
- Subsequent cohort studies – British Doctors Study - provided firm evidence of relationship- demonstrated reversibility of effect
![Page 25: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/25.jpg)
Sir Richard Doll (1912 – 2005) was a British physiologist who became the foremost epidemiologist of the 20th century. He was a pioneer in research linking smoking to health problems. With Bradford Hill, he was credited with being the first to prove that smoking caused lung cancer and increased the risk of heart disease.
• Sir Austin Hill(1897 - 1991), English epidemiologist and statistician, pioneered the randomized clinical trial and, together with Richard Doll, was the first to demonstrate the connection between cigarette smoking and lung cancer.
![Page 26: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/26.jpg)
Use of epidemiology
• Disease surveillance• Causation• Natural history of disease• Description of health status in populations• Evaluation of interventions
![Page 27: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/27.jpg)
Use of epidemiology (Disease surveillance)
1. Frequency with which the disease occurs
2. Definition of the disease 3. Size of the population
from which the cases develop
4. Completeness of the reporting of the cases.
![Page 28: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/28.jpg)
Use of epidemiology (Causation)
Good health Ill health
Genetic factors
Environmental factors (including life style)
![Page 29: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/29.jpg)
Natural history of diseaseNatural history of disease
Stage ofsusceptibility
Stage of subclinical
disease
Stage of clinical disease
Stage of recovery,
disability or death
PRIMARY PRIMARY PREVENTIONPREVENTION SECONDARY SECONDARY
PREVENTIONPREVENTION TERTIARY TERTIARY PREVENTIONPREVENTION
Exposure
Pathologicchanges
Onset of symptoms
Usual time of diagnosis
![Page 30: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/30.jpg)
Use of epidemiology(Description of health status in populations)
Good health
Ill health
TimeProportion with ill health,change over time, change with age, etc.
![Page 31: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/31.jpg)
Use of epidemiology(Evaluation of interventions)
Good health Ill health
Health promotionPreventive measuresPublic health services
![Page 32: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/32.jpg)
Two Broad Types of EpidemiologyTwo Broad Types of Epidemiology
Examining the distribution of a disease in a population, and observing the basic features of its distribution in terms of time, place, and person.
Typical study design:
community health survey (approximate synonyms - cross-sectional study, descriptive study)
Hypothesis generating
Testing a specific hypothesis about the relationship of a disease to a putative cause, by conducting an epidemiologic study that relates the exposure of interest to the disease of interest.
Typical study designs: cohort, case-control
Hypothesis testing
DESCRIPTIVE EPIDEMIOLOGY ANALYTIC EPIDEMIOLOGY
![Page 33: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/33.jpg)
Two Broad Types of EpidemiologyTwo Broad Types of Epidemiology
what Hypothesis generating
States what happened
Explains what a theory says
Lists details
why
Hypothesis testingIdentifies the significance
Shows why something is relevant or suitable
Evaluates the relative significance of details
DESCRIPTIVE EPIDEMIOLOGY ANALYTIC EPIDEMIOLOGY
Her skin is very white, a heritage from her mother.
![Page 34: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/34.jpg)
Descriptive Studies• Correlational studies (may be called ecological
studies)– Examine characteristics of entire populations
• Example: Examination of state data on tobacco sales and mortality from CHD
– First step in examination of a disease exposure relationship
– Strength • Quick and inexpensive, can be used as first step
– Limitation• Doesn’t link specific persons’ exposure with specific outcome
Risk of ecological fallacy• Can’t control for potential confounding factors
![Page 35: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/35.jpg)
Descriptive Studies• Case Reports and Case Series
– Describes single patient or group of patients experience
– Most common form of study published in medical journals
– Strengths• May lead to formulation of new hypotheses
• Important link between clinical medicine and epidemiology
– Limitation• Cannot be used to test hypotheses
![Page 36: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/36.jpg)
Descriptive Studies• Cross-Sectional (or prevalence) Survey
– Exposure and disease status are simultaneously assessed in a population
– Strength• Provides information about the frequency and characteristics
of a disease– Useful for public health– Can provide information concerning the prevalence of
disease or other health outcome in special groups (e.g. occupations)
– Limitation• Can’t determine whether exposure preceded or occurred as a
result of the disease
![Page 37: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/37.jpg)
Descriptive Epidemiology Is Descriptive Epidemiology Is A Necessary Antecedent Of A Necessary Antecedent Of
Analytic EpidemiologyAnalytic Epidemiology To undertake an analytic
epidemiologic study you must first:• Know where to look • Know what to control for • Be able to formulate hypotheses
compatible with laboratory evidence
![Page 38: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/38.jpg)
The Basic Triad Of The Basic Triad Of Analytic EpidemiologyAnalytic Epidemiology
THE THREE PHENOMENA ASSESSED IN ANALYTIC EPIDEMIOLOGY ARE:
HOST
ENVIRONMENTAGENT
![Page 39: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/39.jpg)
AgentsAgents
• Nutrients• Poisons • Allergens • Radiation • Physical trauma • Microbes • Psychological experiences
![Page 40: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/40.jpg)
Host FactorsHost Factors
• Genetic endowment
• Immunologic state
• Age
• Personal behavior
![Page 41: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/41.jpg)
EnvironmentEnvironment
• Crowding
• Atmosphere• Modes of communication –
phenomena in the environment that bring host and agent together, such as:– Vector– Vehicle
![Page 42: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/42.jpg)
Analytic Studies• Explicit comparison of exposure and disease
• Groups are assembled to determine whether risk is different for exposed and unexposed
• Appropriate comparison group
• Hypothesis testing
• Two types– Observational - natural course of events
– Intervention - investigator allocates exposure and follows subjects
![Page 43: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/43.jpg)
Observational Studies• Case-Control
– Persons with disease
– Comparison group
• Cohort– Subjects classified on basis of exposure of a
factor
– Follow-up to determine presence of disease• Prospective vs. retrospective
![Page 44: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/44.jpg)
Intervention Studies• Experimental studies - clinical trials
– Provides most reliable evidence
– Randomization• Controls for known risk factors
• Controls for unknown risk factors
– Useful for studying small to moderate effects
– Ethical considerations• Human rights review
• Data monitoring – “DSMB”
![Page 45: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/45.jpg)
Assign exposures?
Experimental study Observational study
Random allocation? Comparison group?
Randomized controlled
trial
Non-randomized controlled
trial
Analyticalstudy
Descriptivestudy
Direction?
Cohort study
Case-control study
Cross-sectional
study
Yes No
Yes YesNo No
Exposure Outcome Exposure Outcome Exposure and Outcome at the same time
![Page 46: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/46.jpg)
Epidemiologists are required to have some knowledge of the disciplines of public health, clinical medicine, pathophysiology, statistics, and the social sciences.
• public health, because of the emphasis on disease prevention.
• clinical medicine, because of the emphasis on disease classification and diagnosis.
• pathophysiology, because of the need to understand basic biological mechanisms in disease.
• statistics, because of the need to quantify disease frequency and its relationships to antecedents.
• social sciences, because of the need to understand the social context in which disease occurs and presents.
![Page 47: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/47.jpg)
Purposes Of EpidemiologyPurposes Of Epidemiology
1. Identify causes and risk factors for disease.
2. Determine the extent of disease in the community.
3. Study natural history and prognosis of disease.
4. Evaluate preventive and therapeutic measures
5. Provide foundation for public policy
![Page 48: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/48.jpg)
Men Women
Children
Total
1st class 67% 3% 0 38%
2nd class 92% 14% 0 59%
3rd class 84% 54% 66% 62%
Total 82% 26% 48% 62%
EVERY HEALTH OUTCOME HAS SOME INTERESTING AND USEFUL EPIDEMIOLOGIC
CHARACTERISTIC
DEATH RATES BY SOCIAL CLASS FROM A CERTAIN CAUSE AMONG 1,316 PEOPLE
WHAT CAUSE OF DEATH IS THIS?
![Page 49: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/49.jpg)
The previous slide shows death The previous slide shows death rates by class of ticket on the rates by class of ticket on the
Titanic, a large ocean liner that Titanic, a large ocean liner that sank after colliding with an iceberg sank after colliding with an iceberg
in 1912 in 1912
![Page 50: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/50.jpg)
Clinical Epidemiology
Epidemiology is used in clinical medicine to:
• evaluate diagnostic testing • evaluate prognosis • The goal
- by improving diagnosis and treatment of disease
- by improving the prognosis of patients not to prevent the disease, just to promote clinicial
decisions.
[Greenberg RS (ed.) Medical Epidemiology, 1993]
![Page 51: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/51.jpg)
1 MacMahon B and Pugh TF. Epidemiology Principles and Methods. Boston: Little, Brown and Company. 1970.
2 Lilienfeld AM and Lilienfeld DE. Foundations of Epidemiology (2nd ed.). New York: Oxford University Press. 1980
3 Last JM. A dictionary of epidemiology. Oxford University Press. 1983.
4 Haynes RB, Sackett DL, Guyatt GH, Tugwell P. Clinical Epidemiology: How to Do Clinical Practice Research, 3rd edition. Philadelphia: Lippincott Williams & Wilkins, 2005.
5 Rothman KJ. Modern Epidemiology, 3rd. Lippincott Williams & Wilkins. 2008
Classic BooksClassic Books
![Page 52: Introduction to clinical epidemiology Hui Jin Department of Epidemiology and Health Statistics School of Public Health Southeast University Email: jinhuimc@163.comjinhuimc@163.com](https://reader035.vdocuments.mx/reader035/viewer/2022062308/56649cc45503460f9498cbe8/html5/thumbnails/52.jpg)
Question?
Assigned readings, session 1:• Grimes DA, Schulz KF. An overview of clinical
research: the lay of the land. Lancet 2002; 359:57-61.
What is epidemiology?
What is the limitation of epidemiology?