introduction to cancer diagnosis & treatment
DESCRIPTION
Introduction To Cancer Diagnosis & Treatment. By Prof Ahmed Abd El-Warith. Objectives. 1- definition of cancer 2- etiology of cancer 3- staging of malignant diseases 4- principals of pathological classification of malignant diseases 5- general symptoms and signs of malignancy - PowerPoint PPT PresentationTRANSCRIPT
Introduction To Cancer Diagnosis amp Treatment
By
Prof Ahmed Abd El-Warith
Objectives bull 1- definition of cancer
bull 2- etiology of cancer
bull 3- staging of malignant diseases
bull 4- principals of pathological classification of malignant diseases
bull 5- general symptoms and signs of malignancy
bull 6- principals of cancer management
( curative Vs palliative concept)
Definitions
Defining Cancer
Cancer is a term used for diseases in which abnormal cells divide and
escape the body control
These cells are able to
1-Invade surrounding tissues
2-Send distant metastases
3 -Lost their functions
Abnormal cell division Normal cell division
Cth toxicityHairEpitheliumNailsGerm cellsBone marrow
Escape body control
Suppressed immunityDisease
-Drugs-Infective agents
Defining Cancer
bull1048708 Primary Tumors
Represent de novo tumors in their initial site
bull1048708 Metastatic Tumors
Originate from the distant growth of the
primary tumors
History
scienceblogcancerresearchukorg
Posted on October 14 2010 by Kat Arney
Claims that cancer is only a lsquomodern man-made diseasersquo are false and
misleading
This is not only scientifically incorrect but misleading
Cancer has always been with us from ancient civilizations to today
Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of CancerBy Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou
Annals of Surgical Oncology Vol17 (2010)
The origin of the word lsquolsquocancerrsquorsquo is credited to the Hippocratic physicians who used the terms karkinos and karkinoma
What causes cancer
DNA controls cell functions
Cell division
Nucleolus control the cell function
Stem
cell end stage
Development of Malignant Disease
Cell Arrest amp clonal expansion
Genetic mutation
Activation of pro=oncogene
What causes cancer
Cancer arises from the mutation of a normal gene
Mutated genes that cause cancer are called oncogenes
Causes of Cancer
bull bullDNA Mutations
bull ndashRadiation ndash and other environmental factors (Tobacco Alcohol Radon Asbestos etc)
bull ndashRandom somatic mutations
bull ndashInherited germ line mutations
Causes of Cancer
bull bullGenetic predisposition-bull ndashRb p53 APC CDKN2A BRCA1 BRCA2
bull bullInfectious agentsbull ndashViral
bull bullHPV ndash cervical cancerbull bullHepatitis ndash liver cancer
bullndashBacterialbull bullH pylori ndash stomach cancer
bullEBV - Lymphoma
Hallmarks of Cancerbull Summarized by Hanahan and Weinberg (2000)
Six changes for cancer ndash found in most if not all
bull1ndash Self-sufficiency in growth signals
bull2 ndashInsensitivity to growth-inhibitory signals
bull3 ndashAbsence of apoptosisbull4 ndashLimitless prolferative
capacitybull5 ndashSustained angiogenesis
bull6 ndashTissue invasion and metastasis
If you decided to be an oncologist What should you know
bull 1-When to suspect cancerbull 2-How to diagnose cancerbull 3-What the essential work up for
stagingbull 4-How to treat cancerbull 5-What is the prognosis of your
patient
1 -When to suspect cancer
Cancer Signs and Symptoms-Cancer gives most people no symptoms
or signs that exclusively indicate the disease
-Unfortunately every complaint or symptom of cancer can be explained by a
harmless condition as well
1 -When to suspect cancer
Cancer Signs and Symptoms
What are the clues-Persistent
-Progressive-Disabling
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Objectives bull 1- definition of cancer
bull 2- etiology of cancer
bull 3- staging of malignant diseases
bull 4- principals of pathological classification of malignant diseases
bull 5- general symptoms and signs of malignancy
bull 6- principals of cancer management
( curative Vs palliative concept)
Definitions
Defining Cancer
Cancer is a term used for diseases in which abnormal cells divide and
escape the body control
These cells are able to
1-Invade surrounding tissues
2-Send distant metastases
3 -Lost their functions
Abnormal cell division Normal cell division
Cth toxicityHairEpitheliumNailsGerm cellsBone marrow
Escape body control
Suppressed immunityDisease
-Drugs-Infective agents
Defining Cancer
bull1048708 Primary Tumors
Represent de novo tumors in their initial site
bull1048708 Metastatic Tumors
Originate from the distant growth of the
primary tumors
History
scienceblogcancerresearchukorg
Posted on October 14 2010 by Kat Arney
Claims that cancer is only a lsquomodern man-made diseasersquo are false and
misleading
This is not only scientifically incorrect but misleading
Cancer has always been with us from ancient civilizations to today
Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of CancerBy Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou
Annals of Surgical Oncology Vol17 (2010)
The origin of the word lsquolsquocancerrsquorsquo is credited to the Hippocratic physicians who used the terms karkinos and karkinoma
What causes cancer
DNA controls cell functions
Cell division
Nucleolus control the cell function
Stem
cell end stage
Development of Malignant Disease
Cell Arrest amp clonal expansion
Genetic mutation
Activation of pro=oncogene
What causes cancer
Cancer arises from the mutation of a normal gene
Mutated genes that cause cancer are called oncogenes
Causes of Cancer
bull bullDNA Mutations
bull ndashRadiation ndash and other environmental factors (Tobacco Alcohol Radon Asbestos etc)
bull ndashRandom somatic mutations
bull ndashInherited germ line mutations
Causes of Cancer
bull bullGenetic predisposition-bull ndashRb p53 APC CDKN2A BRCA1 BRCA2
bull bullInfectious agentsbull ndashViral
bull bullHPV ndash cervical cancerbull bullHepatitis ndash liver cancer
bullndashBacterialbull bullH pylori ndash stomach cancer
bullEBV - Lymphoma
Hallmarks of Cancerbull Summarized by Hanahan and Weinberg (2000)
Six changes for cancer ndash found in most if not all
bull1ndash Self-sufficiency in growth signals
bull2 ndashInsensitivity to growth-inhibitory signals
bull3 ndashAbsence of apoptosisbull4 ndashLimitless prolferative
capacitybull5 ndashSustained angiogenesis
bull6 ndashTissue invasion and metastasis
If you decided to be an oncologist What should you know
bull 1-When to suspect cancerbull 2-How to diagnose cancerbull 3-What the essential work up for
stagingbull 4-How to treat cancerbull 5-What is the prognosis of your
patient
1 -When to suspect cancer
Cancer Signs and Symptoms-Cancer gives most people no symptoms
or signs that exclusively indicate the disease
-Unfortunately every complaint or symptom of cancer can be explained by a
harmless condition as well
1 -When to suspect cancer
Cancer Signs and Symptoms
What are the clues-Persistent
-Progressive-Disabling
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Definitions
Defining Cancer
Cancer is a term used for diseases in which abnormal cells divide and
escape the body control
These cells are able to
1-Invade surrounding tissues
2-Send distant metastases
3 -Lost their functions
Abnormal cell division Normal cell division
Cth toxicityHairEpitheliumNailsGerm cellsBone marrow
Escape body control
Suppressed immunityDisease
-Drugs-Infective agents
Defining Cancer
bull1048708 Primary Tumors
Represent de novo tumors in their initial site
bull1048708 Metastatic Tumors
Originate from the distant growth of the
primary tumors
History
scienceblogcancerresearchukorg
Posted on October 14 2010 by Kat Arney
Claims that cancer is only a lsquomodern man-made diseasersquo are false and
misleading
This is not only scientifically incorrect but misleading
Cancer has always been with us from ancient civilizations to today
Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of CancerBy Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou
Annals of Surgical Oncology Vol17 (2010)
The origin of the word lsquolsquocancerrsquorsquo is credited to the Hippocratic physicians who used the terms karkinos and karkinoma
What causes cancer
DNA controls cell functions
Cell division
Nucleolus control the cell function
Stem
cell end stage
Development of Malignant Disease
Cell Arrest amp clonal expansion
Genetic mutation
Activation of pro=oncogene
What causes cancer
Cancer arises from the mutation of a normal gene
Mutated genes that cause cancer are called oncogenes
Causes of Cancer
bull bullDNA Mutations
bull ndashRadiation ndash and other environmental factors (Tobacco Alcohol Radon Asbestos etc)
bull ndashRandom somatic mutations
bull ndashInherited germ line mutations
Causes of Cancer
bull bullGenetic predisposition-bull ndashRb p53 APC CDKN2A BRCA1 BRCA2
bull bullInfectious agentsbull ndashViral
bull bullHPV ndash cervical cancerbull bullHepatitis ndash liver cancer
bullndashBacterialbull bullH pylori ndash stomach cancer
bullEBV - Lymphoma
Hallmarks of Cancerbull Summarized by Hanahan and Weinberg (2000)
Six changes for cancer ndash found in most if not all
bull1ndash Self-sufficiency in growth signals
bull2 ndashInsensitivity to growth-inhibitory signals
bull3 ndashAbsence of apoptosisbull4 ndashLimitless prolferative
capacitybull5 ndashSustained angiogenesis
bull6 ndashTissue invasion and metastasis
If you decided to be an oncologist What should you know
bull 1-When to suspect cancerbull 2-How to diagnose cancerbull 3-What the essential work up for
stagingbull 4-How to treat cancerbull 5-What is the prognosis of your
patient
1 -When to suspect cancer
Cancer Signs and Symptoms-Cancer gives most people no symptoms
or signs that exclusively indicate the disease
-Unfortunately every complaint or symptom of cancer can be explained by a
harmless condition as well
1 -When to suspect cancer
Cancer Signs and Symptoms
What are the clues-Persistent
-Progressive-Disabling
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Defining Cancer
Cancer is a term used for diseases in which abnormal cells divide and
escape the body control
These cells are able to
1-Invade surrounding tissues
2-Send distant metastases
3 -Lost their functions
Abnormal cell division Normal cell division
Cth toxicityHairEpitheliumNailsGerm cellsBone marrow
Escape body control
Suppressed immunityDisease
-Drugs-Infective agents
Defining Cancer
bull1048708 Primary Tumors
Represent de novo tumors in their initial site
bull1048708 Metastatic Tumors
Originate from the distant growth of the
primary tumors
History
scienceblogcancerresearchukorg
Posted on October 14 2010 by Kat Arney
Claims that cancer is only a lsquomodern man-made diseasersquo are false and
misleading
This is not only scientifically incorrect but misleading
Cancer has always been with us from ancient civilizations to today
Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of CancerBy Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou
Annals of Surgical Oncology Vol17 (2010)
The origin of the word lsquolsquocancerrsquorsquo is credited to the Hippocratic physicians who used the terms karkinos and karkinoma
What causes cancer
DNA controls cell functions
Cell division
Nucleolus control the cell function
Stem
cell end stage
Development of Malignant Disease
Cell Arrest amp clonal expansion
Genetic mutation
Activation of pro=oncogene
What causes cancer
Cancer arises from the mutation of a normal gene
Mutated genes that cause cancer are called oncogenes
Causes of Cancer
bull bullDNA Mutations
bull ndashRadiation ndash and other environmental factors (Tobacco Alcohol Radon Asbestos etc)
bull ndashRandom somatic mutations
bull ndashInherited germ line mutations
Causes of Cancer
bull bullGenetic predisposition-bull ndashRb p53 APC CDKN2A BRCA1 BRCA2
bull bullInfectious agentsbull ndashViral
bull bullHPV ndash cervical cancerbull bullHepatitis ndash liver cancer
bullndashBacterialbull bullH pylori ndash stomach cancer
bullEBV - Lymphoma
Hallmarks of Cancerbull Summarized by Hanahan and Weinberg (2000)
Six changes for cancer ndash found in most if not all
bull1ndash Self-sufficiency in growth signals
bull2 ndashInsensitivity to growth-inhibitory signals
bull3 ndashAbsence of apoptosisbull4 ndashLimitless prolferative
capacitybull5 ndashSustained angiogenesis
bull6 ndashTissue invasion and metastasis
If you decided to be an oncologist What should you know
bull 1-When to suspect cancerbull 2-How to diagnose cancerbull 3-What the essential work up for
stagingbull 4-How to treat cancerbull 5-What is the prognosis of your
patient
1 -When to suspect cancer
Cancer Signs and Symptoms-Cancer gives most people no symptoms
or signs that exclusively indicate the disease
-Unfortunately every complaint or symptom of cancer can be explained by a
harmless condition as well
1 -When to suspect cancer
Cancer Signs and Symptoms
What are the clues-Persistent
-Progressive-Disabling
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Abnormal cell division Normal cell division
Cth toxicityHairEpitheliumNailsGerm cellsBone marrow
Escape body control
Suppressed immunityDisease
-Drugs-Infective agents
Defining Cancer
bull1048708 Primary Tumors
Represent de novo tumors in their initial site
bull1048708 Metastatic Tumors
Originate from the distant growth of the
primary tumors
History
scienceblogcancerresearchukorg
Posted on October 14 2010 by Kat Arney
Claims that cancer is only a lsquomodern man-made diseasersquo are false and
misleading
This is not only scientifically incorrect but misleading
Cancer has always been with us from ancient civilizations to today
Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of CancerBy Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou
Annals of Surgical Oncology Vol17 (2010)
The origin of the word lsquolsquocancerrsquorsquo is credited to the Hippocratic physicians who used the terms karkinos and karkinoma
What causes cancer
DNA controls cell functions
Cell division
Nucleolus control the cell function
Stem
cell end stage
Development of Malignant Disease
Cell Arrest amp clonal expansion
Genetic mutation
Activation of pro=oncogene
What causes cancer
Cancer arises from the mutation of a normal gene
Mutated genes that cause cancer are called oncogenes
Causes of Cancer
bull bullDNA Mutations
bull ndashRadiation ndash and other environmental factors (Tobacco Alcohol Radon Asbestos etc)
bull ndashRandom somatic mutations
bull ndashInherited germ line mutations
Causes of Cancer
bull bullGenetic predisposition-bull ndashRb p53 APC CDKN2A BRCA1 BRCA2
bull bullInfectious agentsbull ndashViral
bull bullHPV ndash cervical cancerbull bullHepatitis ndash liver cancer
bullndashBacterialbull bullH pylori ndash stomach cancer
bullEBV - Lymphoma
Hallmarks of Cancerbull Summarized by Hanahan and Weinberg (2000)
Six changes for cancer ndash found in most if not all
bull1ndash Self-sufficiency in growth signals
bull2 ndashInsensitivity to growth-inhibitory signals
bull3 ndashAbsence of apoptosisbull4 ndashLimitless prolferative
capacitybull5 ndashSustained angiogenesis
bull6 ndashTissue invasion and metastasis
If you decided to be an oncologist What should you know
bull 1-When to suspect cancerbull 2-How to diagnose cancerbull 3-What the essential work up for
stagingbull 4-How to treat cancerbull 5-What is the prognosis of your
patient
1 -When to suspect cancer
Cancer Signs and Symptoms-Cancer gives most people no symptoms
or signs that exclusively indicate the disease
-Unfortunately every complaint or symptom of cancer can be explained by a
harmless condition as well
1 -When to suspect cancer
Cancer Signs and Symptoms
What are the clues-Persistent
-Progressive-Disabling
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Defining Cancer
bull1048708 Primary Tumors
Represent de novo tumors in their initial site
bull1048708 Metastatic Tumors
Originate from the distant growth of the
primary tumors
History
scienceblogcancerresearchukorg
Posted on October 14 2010 by Kat Arney
Claims that cancer is only a lsquomodern man-made diseasersquo are false and
misleading
This is not only scientifically incorrect but misleading
Cancer has always been with us from ancient civilizations to today
Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of CancerBy Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou
Annals of Surgical Oncology Vol17 (2010)
The origin of the word lsquolsquocancerrsquorsquo is credited to the Hippocratic physicians who used the terms karkinos and karkinoma
What causes cancer
DNA controls cell functions
Cell division
Nucleolus control the cell function
Stem
cell end stage
Development of Malignant Disease
Cell Arrest amp clonal expansion
Genetic mutation
Activation of pro=oncogene
What causes cancer
Cancer arises from the mutation of a normal gene
Mutated genes that cause cancer are called oncogenes
Causes of Cancer
bull bullDNA Mutations
bull ndashRadiation ndash and other environmental factors (Tobacco Alcohol Radon Asbestos etc)
bull ndashRandom somatic mutations
bull ndashInherited germ line mutations
Causes of Cancer
bull bullGenetic predisposition-bull ndashRb p53 APC CDKN2A BRCA1 BRCA2
bull bullInfectious agentsbull ndashViral
bull bullHPV ndash cervical cancerbull bullHepatitis ndash liver cancer
bullndashBacterialbull bullH pylori ndash stomach cancer
bullEBV - Lymphoma
Hallmarks of Cancerbull Summarized by Hanahan and Weinberg (2000)
Six changes for cancer ndash found in most if not all
bull1ndash Self-sufficiency in growth signals
bull2 ndashInsensitivity to growth-inhibitory signals
bull3 ndashAbsence of apoptosisbull4 ndashLimitless prolferative
capacitybull5 ndashSustained angiogenesis
bull6 ndashTissue invasion and metastasis
If you decided to be an oncologist What should you know
bull 1-When to suspect cancerbull 2-How to diagnose cancerbull 3-What the essential work up for
stagingbull 4-How to treat cancerbull 5-What is the prognosis of your
patient
1 -When to suspect cancer
Cancer Signs and Symptoms-Cancer gives most people no symptoms
or signs that exclusively indicate the disease
-Unfortunately every complaint or symptom of cancer can be explained by a
harmless condition as well
1 -When to suspect cancer
Cancer Signs and Symptoms
What are the clues-Persistent
-Progressive-Disabling
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
History
scienceblogcancerresearchukorg
Posted on October 14 2010 by Kat Arney
Claims that cancer is only a lsquomodern man-made diseasersquo are false and
misleading
This is not only scientifically incorrect but misleading
Cancer has always been with us from ancient civilizations to today
Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of CancerBy Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou
Annals of Surgical Oncology Vol17 (2010)
The origin of the word lsquolsquocancerrsquorsquo is credited to the Hippocratic physicians who used the terms karkinos and karkinoma
What causes cancer
DNA controls cell functions
Cell division
Nucleolus control the cell function
Stem
cell end stage
Development of Malignant Disease
Cell Arrest amp clonal expansion
Genetic mutation
Activation of pro=oncogene
What causes cancer
Cancer arises from the mutation of a normal gene
Mutated genes that cause cancer are called oncogenes
Causes of Cancer
bull bullDNA Mutations
bull ndashRadiation ndash and other environmental factors (Tobacco Alcohol Radon Asbestos etc)
bull ndashRandom somatic mutations
bull ndashInherited germ line mutations
Causes of Cancer
bull bullGenetic predisposition-bull ndashRb p53 APC CDKN2A BRCA1 BRCA2
bull bullInfectious agentsbull ndashViral
bull bullHPV ndash cervical cancerbull bullHepatitis ndash liver cancer
bullndashBacterialbull bullH pylori ndash stomach cancer
bullEBV - Lymphoma
Hallmarks of Cancerbull Summarized by Hanahan and Weinberg (2000)
Six changes for cancer ndash found in most if not all
bull1ndash Self-sufficiency in growth signals
bull2 ndashInsensitivity to growth-inhibitory signals
bull3 ndashAbsence of apoptosisbull4 ndashLimitless prolferative
capacitybull5 ndashSustained angiogenesis
bull6 ndashTissue invasion and metastasis
If you decided to be an oncologist What should you know
bull 1-When to suspect cancerbull 2-How to diagnose cancerbull 3-What the essential work up for
stagingbull 4-How to treat cancerbull 5-What is the prognosis of your
patient
1 -When to suspect cancer
Cancer Signs and Symptoms-Cancer gives most people no symptoms
or signs that exclusively indicate the disease
-Unfortunately every complaint or symptom of cancer can be explained by a
harmless condition as well
1 -When to suspect cancer
Cancer Signs and Symptoms
What are the clues-Persistent
-Progressive-Disabling
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
scienceblogcancerresearchukorg
Posted on October 14 2010 by Kat Arney
Claims that cancer is only a lsquomodern man-made diseasersquo are false and
misleading
This is not only scientifically incorrect but misleading
Cancer has always been with us from ancient civilizations to today
Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of CancerBy Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou
Annals of Surgical Oncology Vol17 (2010)
The origin of the word lsquolsquocancerrsquorsquo is credited to the Hippocratic physicians who used the terms karkinos and karkinoma
What causes cancer
DNA controls cell functions
Cell division
Nucleolus control the cell function
Stem
cell end stage
Development of Malignant Disease
Cell Arrest amp clonal expansion
Genetic mutation
Activation of pro=oncogene
What causes cancer
Cancer arises from the mutation of a normal gene
Mutated genes that cause cancer are called oncogenes
Causes of Cancer
bull bullDNA Mutations
bull ndashRadiation ndash and other environmental factors (Tobacco Alcohol Radon Asbestos etc)
bull ndashRandom somatic mutations
bull ndashInherited germ line mutations
Causes of Cancer
bull bullGenetic predisposition-bull ndashRb p53 APC CDKN2A BRCA1 BRCA2
bull bullInfectious agentsbull ndashViral
bull bullHPV ndash cervical cancerbull bullHepatitis ndash liver cancer
bullndashBacterialbull bullH pylori ndash stomach cancer
bullEBV - Lymphoma
Hallmarks of Cancerbull Summarized by Hanahan and Weinberg (2000)
Six changes for cancer ndash found in most if not all
bull1ndash Self-sufficiency in growth signals
bull2 ndashInsensitivity to growth-inhibitory signals
bull3 ndashAbsence of apoptosisbull4 ndashLimitless prolferative
capacitybull5 ndashSustained angiogenesis
bull6 ndashTissue invasion and metastasis
If you decided to be an oncologist What should you know
bull 1-When to suspect cancerbull 2-How to diagnose cancerbull 3-What the essential work up for
stagingbull 4-How to treat cancerbull 5-What is the prognosis of your
patient
1 -When to suspect cancer
Cancer Signs and Symptoms-Cancer gives most people no symptoms
or signs that exclusively indicate the disease
-Unfortunately every complaint or symptom of cancer can be explained by a
harmless condition as well
1 -When to suspect cancer
Cancer Signs and Symptoms
What are the clues-Persistent
-Progressive-Disabling
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of CancerBy Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou
Annals of Surgical Oncology Vol17 (2010)
The origin of the word lsquolsquocancerrsquorsquo is credited to the Hippocratic physicians who used the terms karkinos and karkinoma
What causes cancer
DNA controls cell functions
Cell division
Nucleolus control the cell function
Stem
cell end stage
Development of Malignant Disease
Cell Arrest amp clonal expansion
Genetic mutation
Activation of pro=oncogene
What causes cancer
Cancer arises from the mutation of a normal gene
Mutated genes that cause cancer are called oncogenes
Causes of Cancer
bull bullDNA Mutations
bull ndashRadiation ndash and other environmental factors (Tobacco Alcohol Radon Asbestos etc)
bull ndashRandom somatic mutations
bull ndashInherited germ line mutations
Causes of Cancer
bull bullGenetic predisposition-bull ndashRb p53 APC CDKN2A BRCA1 BRCA2
bull bullInfectious agentsbull ndashViral
bull bullHPV ndash cervical cancerbull bullHepatitis ndash liver cancer
bullndashBacterialbull bullH pylori ndash stomach cancer
bullEBV - Lymphoma
Hallmarks of Cancerbull Summarized by Hanahan and Weinberg (2000)
Six changes for cancer ndash found in most if not all
bull1ndash Self-sufficiency in growth signals
bull2 ndashInsensitivity to growth-inhibitory signals
bull3 ndashAbsence of apoptosisbull4 ndashLimitless prolferative
capacitybull5 ndashSustained angiogenesis
bull6 ndashTissue invasion and metastasis
If you decided to be an oncologist What should you know
bull 1-When to suspect cancerbull 2-How to diagnose cancerbull 3-What the essential work up for
stagingbull 4-How to treat cancerbull 5-What is the prognosis of your
patient
1 -When to suspect cancer
Cancer Signs and Symptoms-Cancer gives most people no symptoms
or signs that exclusively indicate the disease
-Unfortunately every complaint or symptom of cancer can be explained by a
harmless condition as well
1 -When to suspect cancer
Cancer Signs and Symptoms
What are the clues-Persistent
-Progressive-Disabling
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
What causes cancer
DNA controls cell functions
Cell division
Nucleolus control the cell function
Stem
cell end stage
Development of Malignant Disease
Cell Arrest amp clonal expansion
Genetic mutation
Activation of pro=oncogene
What causes cancer
Cancer arises from the mutation of a normal gene
Mutated genes that cause cancer are called oncogenes
Causes of Cancer
bull bullDNA Mutations
bull ndashRadiation ndash and other environmental factors (Tobacco Alcohol Radon Asbestos etc)
bull ndashRandom somatic mutations
bull ndashInherited germ line mutations
Causes of Cancer
bull bullGenetic predisposition-bull ndashRb p53 APC CDKN2A BRCA1 BRCA2
bull bullInfectious agentsbull ndashViral
bull bullHPV ndash cervical cancerbull bullHepatitis ndash liver cancer
bullndashBacterialbull bullH pylori ndash stomach cancer
bullEBV - Lymphoma
Hallmarks of Cancerbull Summarized by Hanahan and Weinberg (2000)
Six changes for cancer ndash found in most if not all
bull1ndash Self-sufficiency in growth signals
bull2 ndashInsensitivity to growth-inhibitory signals
bull3 ndashAbsence of apoptosisbull4 ndashLimitless prolferative
capacitybull5 ndashSustained angiogenesis
bull6 ndashTissue invasion and metastasis
If you decided to be an oncologist What should you know
bull 1-When to suspect cancerbull 2-How to diagnose cancerbull 3-What the essential work up for
stagingbull 4-How to treat cancerbull 5-What is the prognosis of your
patient
1 -When to suspect cancer
Cancer Signs and Symptoms-Cancer gives most people no symptoms
or signs that exclusively indicate the disease
-Unfortunately every complaint or symptom of cancer can be explained by a
harmless condition as well
1 -When to suspect cancer
Cancer Signs and Symptoms
What are the clues-Persistent
-Progressive-Disabling
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
DNA controls cell functions
Cell division
Nucleolus control the cell function
Stem
cell end stage
Development of Malignant Disease
Cell Arrest amp clonal expansion
Genetic mutation
Activation of pro=oncogene
What causes cancer
Cancer arises from the mutation of a normal gene
Mutated genes that cause cancer are called oncogenes
Causes of Cancer
bull bullDNA Mutations
bull ndashRadiation ndash and other environmental factors (Tobacco Alcohol Radon Asbestos etc)
bull ndashRandom somatic mutations
bull ndashInherited germ line mutations
Causes of Cancer
bull bullGenetic predisposition-bull ndashRb p53 APC CDKN2A BRCA1 BRCA2
bull bullInfectious agentsbull ndashViral
bull bullHPV ndash cervical cancerbull bullHepatitis ndash liver cancer
bullndashBacterialbull bullH pylori ndash stomach cancer
bullEBV - Lymphoma
Hallmarks of Cancerbull Summarized by Hanahan and Weinberg (2000)
Six changes for cancer ndash found in most if not all
bull1ndash Self-sufficiency in growth signals
bull2 ndashInsensitivity to growth-inhibitory signals
bull3 ndashAbsence of apoptosisbull4 ndashLimitless prolferative
capacitybull5 ndashSustained angiogenesis
bull6 ndashTissue invasion and metastasis
If you decided to be an oncologist What should you know
bull 1-When to suspect cancerbull 2-How to diagnose cancerbull 3-What the essential work up for
stagingbull 4-How to treat cancerbull 5-What is the prognosis of your
patient
1 -When to suspect cancer
Cancer Signs and Symptoms-Cancer gives most people no symptoms
or signs that exclusively indicate the disease
-Unfortunately every complaint or symptom of cancer can be explained by a
harmless condition as well
1 -When to suspect cancer
Cancer Signs and Symptoms
What are the clues-Persistent
-Progressive-Disabling
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Stem
cell end stage
Development of Malignant Disease
Cell Arrest amp clonal expansion
Genetic mutation
Activation of pro=oncogene
What causes cancer
Cancer arises from the mutation of a normal gene
Mutated genes that cause cancer are called oncogenes
Causes of Cancer
bull bullDNA Mutations
bull ndashRadiation ndash and other environmental factors (Tobacco Alcohol Radon Asbestos etc)
bull ndashRandom somatic mutations
bull ndashInherited germ line mutations
Causes of Cancer
bull bullGenetic predisposition-bull ndashRb p53 APC CDKN2A BRCA1 BRCA2
bull bullInfectious agentsbull ndashViral
bull bullHPV ndash cervical cancerbull bullHepatitis ndash liver cancer
bullndashBacterialbull bullH pylori ndash stomach cancer
bullEBV - Lymphoma
Hallmarks of Cancerbull Summarized by Hanahan and Weinberg (2000)
Six changes for cancer ndash found in most if not all
bull1ndash Self-sufficiency in growth signals
bull2 ndashInsensitivity to growth-inhibitory signals
bull3 ndashAbsence of apoptosisbull4 ndashLimitless prolferative
capacitybull5 ndashSustained angiogenesis
bull6 ndashTissue invasion and metastasis
If you decided to be an oncologist What should you know
bull 1-When to suspect cancerbull 2-How to diagnose cancerbull 3-What the essential work up for
stagingbull 4-How to treat cancerbull 5-What is the prognosis of your
patient
1 -When to suspect cancer
Cancer Signs and Symptoms-Cancer gives most people no symptoms
or signs that exclusively indicate the disease
-Unfortunately every complaint or symptom of cancer can be explained by a
harmless condition as well
1 -When to suspect cancer
Cancer Signs and Symptoms
What are the clues-Persistent
-Progressive-Disabling
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
What causes cancer
Cancer arises from the mutation of a normal gene
Mutated genes that cause cancer are called oncogenes
Causes of Cancer
bull bullDNA Mutations
bull ndashRadiation ndash and other environmental factors (Tobacco Alcohol Radon Asbestos etc)
bull ndashRandom somatic mutations
bull ndashInherited germ line mutations
Causes of Cancer
bull bullGenetic predisposition-bull ndashRb p53 APC CDKN2A BRCA1 BRCA2
bull bullInfectious agentsbull ndashViral
bull bullHPV ndash cervical cancerbull bullHepatitis ndash liver cancer
bullndashBacterialbull bullH pylori ndash stomach cancer
bullEBV - Lymphoma
Hallmarks of Cancerbull Summarized by Hanahan and Weinberg (2000)
Six changes for cancer ndash found in most if not all
bull1ndash Self-sufficiency in growth signals
bull2 ndashInsensitivity to growth-inhibitory signals
bull3 ndashAbsence of apoptosisbull4 ndashLimitless prolferative
capacitybull5 ndashSustained angiogenesis
bull6 ndashTissue invasion and metastasis
If you decided to be an oncologist What should you know
bull 1-When to suspect cancerbull 2-How to diagnose cancerbull 3-What the essential work up for
stagingbull 4-How to treat cancerbull 5-What is the prognosis of your
patient
1 -When to suspect cancer
Cancer Signs and Symptoms-Cancer gives most people no symptoms
or signs that exclusively indicate the disease
-Unfortunately every complaint or symptom of cancer can be explained by a
harmless condition as well
1 -When to suspect cancer
Cancer Signs and Symptoms
What are the clues-Persistent
-Progressive-Disabling
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Causes of Cancer
bull bullDNA Mutations
bull ndashRadiation ndash and other environmental factors (Tobacco Alcohol Radon Asbestos etc)
bull ndashRandom somatic mutations
bull ndashInherited germ line mutations
Causes of Cancer
bull bullGenetic predisposition-bull ndashRb p53 APC CDKN2A BRCA1 BRCA2
bull bullInfectious agentsbull ndashViral
bull bullHPV ndash cervical cancerbull bullHepatitis ndash liver cancer
bullndashBacterialbull bullH pylori ndash stomach cancer
bullEBV - Lymphoma
Hallmarks of Cancerbull Summarized by Hanahan and Weinberg (2000)
Six changes for cancer ndash found in most if not all
bull1ndash Self-sufficiency in growth signals
bull2 ndashInsensitivity to growth-inhibitory signals
bull3 ndashAbsence of apoptosisbull4 ndashLimitless prolferative
capacitybull5 ndashSustained angiogenesis
bull6 ndashTissue invasion and metastasis
If you decided to be an oncologist What should you know
bull 1-When to suspect cancerbull 2-How to diagnose cancerbull 3-What the essential work up for
stagingbull 4-How to treat cancerbull 5-What is the prognosis of your
patient
1 -When to suspect cancer
Cancer Signs and Symptoms-Cancer gives most people no symptoms
or signs that exclusively indicate the disease
-Unfortunately every complaint or symptom of cancer can be explained by a
harmless condition as well
1 -When to suspect cancer
Cancer Signs and Symptoms
What are the clues-Persistent
-Progressive-Disabling
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Causes of Cancer
bull bullGenetic predisposition-bull ndashRb p53 APC CDKN2A BRCA1 BRCA2
bull bullInfectious agentsbull ndashViral
bull bullHPV ndash cervical cancerbull bullHepatitis ndash liver cancer
bullndashBacterialbull bullH pylori ndash stomach cancer
bullEBV - Lymphoma
Hallmarks of Cancerbull Summarized by Hanahan and Weinberg (2000)
Six changes for cancer ndash found in most if not all
bull1ndash Self-sufficiency in growth signals
bull2 ndashInsensitivity to growth-inhibitory signals
bull3 ndashAbsence of apoptosisbull4 ndashLimitless prolferative
capacitybull5 ndashSustained angiogenesis
bull6 ndashTissue invasion and metastasis
If you decided to be an oncologist What should you know
bull 1-When to suspect cancerbull 2-How to diagnose cancerbull 3-What the essential work up for
stagingbull 4-How to treat cancerbull 5-What is the prognosis of your
patient
1 -When to suspect cancer
Cancer Signs and Symptoms-Cancer gives most people no symptoms
or signs that exclusively indicate the disease
-Unfortunately every complaint or symptom of cancer can be explained by a
harmless condition as well
1 -When to suspect cancer
Cancer Signs and Symptoms
What are the clues-Persistent
-Progressive-Disabling
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Hallmarks of Cancerbull Summarized by Hanahan and Weinberg (2000)
Six changes for cancer ndash found in most if not all
bull1ndash Self-sufficiency in growth signals
bull2 ndashInsensitivity to growth-inhibitory signals
bull3 ndashAbsence of apoptosisbull4 ndashLimitless prolferative
capacitybull5 ndashSustained angiogenesis
bull6 ndashTissue invasion and metastasis
If you decided to be an oncologist What should you know
bull 1-When to suspect cancerbull 2-How to diagnose cancerbull 3-What the essential work up for
stagingbull 4-How to treat cancerbull 5-What is the prognosis of your
patient
1 -When to suspect cancer
Cancer Signs and Symptoms-Cancer gives most people no symptoms
or signs that exclusively indicate the disease
-Unfortunately every complaint or symptom of cancer can be explained by a
harmless condition as well
1 -When to suspect cancer
Cancer Signs and Symptoms
What are the clues-Persistent
-Progressive-Disabling
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
If you decided to be an oncologist What should you know
bull 1-When to suspect cancerbull 2-How to diagnose cancerbull 3-What the essential work up for
stagingbull 4-How to treat cancerbull 5-What is the prognosis of your
patient
1 -When to suspect cancer
Cancer Signs and Symptoms-Cancer gives most people no symptoms
or signs that exclusively indicate the disease
-Unfortunately every complaint or symptom of cancer can be explained by a
harmless condition as well
1 -When to suspect cancer
Cancer Signs and Symptoms
What are the clues-Persistent
-Progressive-Disabling
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
1 -When to suspect cancer
Cancer Signs and Symptoms-Cancer gives most people no symptoms
or signs that exclusively indicate the disease
-Unfortunately every complaint or symptom of cancer can be explained by a
harmless condition as well
1 -When to suspect cancer
Cancer Signs and Symptoms
What are the clues-Persistent
-Progressive-Disabling
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
1 -When to suspect cancer
Cancer Signs and Symptoms
What are the clues-Persistent
-Progressive-Disabling
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Cancer Signs and Symptoms
What are the clues -Symptoms amp Signs
changes according to the site of origin
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Cancer Signs and Symptoms
Think about the pathology and site -Mass that is able to invade locally
and spread distantly
Mass
lump
Pressure =on vital
organs
Blood vessels = bleedingNerves = pain
Obstruction =of lumens
To bone brain lung liver
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Cancer Signs and Symptoms
Do not forget the constitutional symptoms
-Fatigue-Fever
-Sweating-Wt loss
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
2 -How to diagnose cancer
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
2 -How to diagnose cancer
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
2 -How to diagnose cancer
CANCER DIAGNOSIS - IS NOT A CLINCAL DIAGNOSIS X
- IT IS NOT A RADIOLOLOGICAL DIAGNOSIS X - IT IS NOT SEROLOGICAL DGNOSIS X
- IT IS A PATHOLOGICAL DIAGNOSI - IT IS A TISSUE DIAGNOSIS-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
GROSS AND MICROSCOPIC PICTURE OF RCC
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Categories of malignant disorders
bull Liquid malignancies
1-Myeloproliferative disorders= leukemia
2-lymphopoliferative disorders= leukemia
bull Solid malignancies
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Categories of malignant disorders
Solid malignancies
Epithelial tissues Connective tissues
Surface glandular Bone Soft tissues
Carcinoma Sarcoma
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
3- What the essential work up for staging
T= tumorN= NodeM= Metastases
Clinical TNMRadiological TNMPathological TNM
-RADIOLOGYXRAYMRICTUS
SURGICAL STAGING
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
4 -How to treat cancer
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Patient withEstablished
Cancer diagnosis
Answer the following questions1-Does the patient have cancer2-What type of cancer3-What stage of cancer
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
ManagementMultidisciplinary
RADIATION MEDICAL ONCSURGERY
-Other Disciplines Radiology Pathology Lab
-Combined clinics-Tumor board
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Types of oncology problems
Patient with Suspected
Cancer diagnosis
Patient withEstablished
Cancer diagnosis
-Define the type-Define the stage Management
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
MANAGEMENT
DETERMINE THE TREATMENT OBJECTIVE
CURATIVE PALLIATIVE
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
TREATMENT MODALITIES
CURATIVE
THERAPY
Aggressive Expensive recent updated complex
TOXICITY
LONG TERM IRREVERSIBLE
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
TREATMENT MODALITIES
PALLIATIVETreatment Simplest Avoid hospitalization Availability
Least toxic
TOXICITY
SHORT TERM ACUTE QUALITY OF LIFE
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Different Treatment Modalities
bull Local therapy = Surgery amp RTH
bull Systemic therapy = Cth Hormones Biologicals
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
Categories of malignant disorders
bull Liquid malignancies 1-Myeloproliferative disorders= leukemia 2-lymphopoliferative disorders= lymphoma
Systemic therapy bull Solid malignancies
According to stage
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
EarlyLocally
Advanced
General Staging of solid malignancies
Metastatic
local
+- Systemic
local
amp Systemic Systemic
+- Local
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
5-What is the prognosis of your patient
What can medicine offer the cancer patient
1-The cancer type amp extent ( stage)2-The host factors (age sex
co morbidities(3 -The available tools
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
5-What is the prognosis of your patient
1- Tumors that can be cured lymphomas leukemia early solid tumors
2- Tumors that can have prolonged survivalLocally advanced and some of the metastatic tumors
3- Tumors that can be palliatedMetastatic solid tumors
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-
THANK YOU
- Introduction To Cancer Diagnosis amp Treatment
- Objectives
- Definitions
- Defining Cancer
- PowerPoint Presentation
- Slide 6
- History
- scienceblogcancerresearchukorg
- Ancient Greek and GrecondashRoman Methods in Modern Surgical Treatment of Cancer By Niki Papavramidou Theodossis Papavramidis and Thespis Demetriou Annals of Surgical Oncology Vol17 (2010)
- What causes cancer
- Slide 11
- Slide 12
- Slide 13
- Causes of Cancer
- Slide 15
- Hallmarks of Cancer bull Summarized by Hanahan and Weinberg (2000) Six changes for cancer ndash found in most if not all
- If you decided to be an oncologist What should you know
- 1- When to suspect cancer
- Slide 19
- Cancer Signs and Symptoms
- Slide 21
- Slide 22
- 2- How to diagnose cancer
- Slide 24
- Slide 25
- GROSS AND MICROSCOPIC PICTURE OF RCC
- Categories of malignant disorders
- Categories of malignant disorders
- 3- What the essential work up for staging
- 4- How to treat cancer
- Slide 31
- Slide 32
- Slide 33
- Slide 34
- Slide 35
- Slide 36
- Slide 37
- Different Treatment Modalities
- Slide 39
- General Staging of solid malignancies
- 5-What is the prognosis of your patient
- Slide 42
- THANK YOU
-