innate + adaptive immunity
DESCRIPTION
Innate + adaptive immunity. Innate immunity only. From Thomas C. G. Bosch (Kiel). Innate Immunity (NK cells, DC, Neutrophils, Monocytes/Macrophages). Effector Functions. « Pathogens ». Initiation of Ag-specific response. Adaptive Immunity (T and B Lymphocytes ). Figure 2-1. - PowerPoint PPT PresentationTRANSCRIPT
Echinodermata
Urochordata
Vertebrata
ChondrichtyesMammalia
Chordata
MHC +TCR +NK cells +Complement system +Complement receptors (SCR) +
MHC -TCR -NK cell receptors +Complement (Bf,C3, C6-C9) +Complement receptors (SCR) +
Agnatha
CionaBotryllusHalocynthia
Petromyzon
innate+ adaptiveimmunity
innate immunity only
Cephalochordata
MHC
NK receptors-570 myr
-525 myr
Innate + adaptive immunity
Innate immunity only
From Thomas C. G. Bosch (Kiel)
« Pathogens »« Pathogens »
Innate ImmunityInnate Immunity(NK cells, DC, Neutrophils, Monocytes/Macrophages)(NK cells, DC, Neutrophils, Monocytes/Macrophages)
Adaptive Immunity Adaptive Immunity (T and B Lymphocytes )(T and B Lymphocytes )
Effector Functions
Initiation of Ag-specific response
Figure 2-1
Toll-like Receptors (TLR):innate immune sensors
Toll and TLRs
Nat Rev Immunol. 2004 Jul;4(7):521-7.
The road to Toll.Lemaitre B.
Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, F-91198 Gif-sur-Yvette, France.
1
PG, LPLP
2 3 4 5 6 7 8 9 10
dsRNALPS
Flagellin
Zym, LP
ssRNA IMQ IMQ CpG
Toll-like receptors
Figure 2-16 part 1 of 2
Figure 2-16 part 2 of 2
Figure 2-17
Mannose Rec. (MR, Endo180, DEC205, PLA2R)C-typeLectins
Others(LRR, CARD,…)
Ig-SF
TLR
h LIR (ILT)m PIR
NCRTREMhKIR
NKRP-1
mLY49
NKG2D
DC-SIGN receptorsDectin-2 (NCCL)Langerin
BDCA-2 (DLEC)
NOD moleculesTLR
Figure 2-5