indrashil university · hetreocycles, alkaloids, terpenes, drugs and pharmaceuticals 3-1-0 4 ......

INDRASHILUNIVERSITY(EstablishedbyanActundertheGujaratPrivateUniversitiesAct,2009)

ALifeSciencesUniversitySustainedExcellencewithRelevance

1

INDRASHIL UNIVERSITY

DEPARTMENT OF CHEMISTRY (CHE)

PROGRAM STRUCTURE

B. Sc CHEMISTRY (Hons) 2019-2022



2

SEMESTER– ISubjectcode SubjectName L-T-P Credits

CH1101FoundationCourseforBiology(GroupA)/FoundationCourseforMathematics

(GroupB)2-0-0 2

CH1102 BasicPhysicsI 3-1-0 4

CH1103 BasicChemistryI 3-1-0 4

CH1104 BasicLifeSciencesI 3-0-0 3

CH1105 EnvironmentalScience 3-1-0 4

CH1106 Lab1VolumetricAnalysis 0-0-4 2

CH1107 Lab2PhysicsI 0-0-4 2

CH1108 Lab3LifeSciencesI 0-0-2 1

IU1001 SoftSkills-I 1-0-0 0

Total 15L+3T+10P 22

SEMESTER– IISubjectcode SubjectName L-T-P Credits

CH1201 BasicPhysicsII 3-1-0 4

CH1202 BasicChemistryII 3-1-0 4

CH1203 BasicLifeSciencesII 3-1-0 4

CH1204 MathematicsandStatistics 3-1-0 4

CH1205 CommunicationSkillsI 1-1-0 2

CH1206 Lab4OrganicandPhysicalChemistry 0-0-4 2

CH1207 Lab5PhysicsII 0-0-4 2

CH1208 Lab 6LifeSciencesII 0-0-4 2

Total 13L+5T+12P 24



3

SEMESTER– IIISubjectcode SubjectName L-T-P Credits

CH2101 PhysicsIII 3-0-0 3

CH2102StereochemistryofCycloalkanes,

ConformationalAnalysisandAromaticity3-0-0 3

CH2103 ChemicalThermodynamics 3-0-0 3

CH2104 LifeSciencesIII 3-0-0 3

CH2105 IndustrialChemistry 2-0-0 2

CH2106 Seminar&SoftSkillsII 1-0-0 1

CH2107 Lab 7OrganicQualitativeAnalysis 0-0-8 4

CH2108 Lab8PhysicsIII 0-0-4 2

CH2109 Lab 9LifeSciencesIII 0-0-4 2

IU2000 CommunityConnectProject 1-0-0 1

Total 16L+16P 24

SEMESTER– IVSubjectcode SubjectName L-T-P Credits

CH2201 PhysicsIV 3-0-0 3

CH2202PeriodicityofElements,Chemistryofsand

pBlockElements,Noblegases3-0-0 3

CH2203ChemicalKinetics,CatalysisandChemical

Equilibrium3-0-0 3

CH2204 LifeSciencesIV 3-0-0 3

CH2205 OrganicChemistry 3-0-0 3

CH2206 CommunicationSkillsII 1-1-0 0

CH2207 Seminar 1-0-0 1

CH2208Lab 10InorganicQualitativeAnalysisand

GravimetricAnalysis0-0-6 3

CH2209 Lab11PhysicalChemistry 0-0-6 3

CH2210 Lab12LifeSciencesIV 0-0-4 2

CH2211 Lab13Physics 0-0-4 2

Total 17L+1T+20P 26



4

SEMESTER– VSubjectcode SubjectName L-T-P Credits

CH3101OrganicReactionsofCarbonylCompounds,SulphurContaining

Compounds3-1-0 4

CH3102 ChemistryofdandfBlockElements 3-1-0 4

CH3103 ElectrochemistryandSurfaceChemistry 3-1-0 4

CH3104MolecularSpectroscopyandStructure

Elucidation3-1-0 4

CH3105 Lab 14OrganicChemistry 0-0-6 3

CH3106 Lab 15PhysicalandInorganic 0-0-6 3

CH3107 Lab16AnalyticalTools 0-0-6 3

Total 12L+4T+18L 25

SEMESTER– VISubjectcode SubjectName L-T-P Credits

CH3201Hetreocycles,alkaloids,terpenes,drugs

andpharmaceuticals3-1-0 4

CH3202 OrganometallicandCatalysis 3-1-0 4

CH3203 QuantumChemistry 3-1-0 4

CH3204 BioorganicandBioinorganicChemistry 3-1-0 4

CH3205ChemistryProject/Industrial

visit/Comprehensiveviva(6sems)0-0-12 6

IU-CCIDInnovativeproject (concept,conceive,

implementanddeliver) 2*

Total 12L+4T+12P 24

*Studentcantakeupthis innovativeprojectin-between Semesters III&IV.Credittohourscalculation:Lecture:1h=1CPracticals:2h=1CTotalCredits:145



5

B.Sc.Chemistry(Hons)SEMESTERI

CH1 101FoundationCourseforBiology(GroupA) (L-T-P-C:2-0-0-2)

Unit1:Origin and evolution of life on earth; Theory of special creation, Cosmogonic theory,Continental Drifting theory; Theory of biogenesis and abiogenesis, Evolution theories(Darwin and Lamarck), Haldane theory of chemical evolution; Theories on structuralcomplementarityofbiomoleculesanditsroleevolution.Urey-millertheory–Ribozymeasevidenceoflife;RNAVsDNAVsProteinworld;EvidenceofDNA;Avery–MacLeod–McCartyexperiments Hershey–Chase Exp.; one gene - one enzyme/one polypeptide/one peptidetheory. Colonizationofmicroorganisms, Endosymbiotic theory.Taxonomy;Five kingdomclassification;Cavalier-Smith’sclassification.Scopeofbiologyinresearchandindustry.Unit2:Buffer Systems in living organisms, biological applications of pH, Some breakthroughdiscoveries in the field of Biology and Chemistry: Louis pasture (Fermentation&microbiology);Vaccination-EdwardJenner,penicillin-AlexanderFleming (1920sto1930s),Tetracycline-Benjamin Minge Duggar (1945),The Human Retrovirus HIV (1980s)-RobertGallo and LucMontagnier, DNA Structure and function-JamesWatson and Francis Crick(1950s);Bragg's x-ray crystallography, Magic bullet of Paul Ehrlich (Salavarsan) andAspirin-1899Bayer,Insulin-1922,Globalwarmingandemergenceofdiseases.ConceptsofMultidrugresistance.Roleofchemistsindrugdiscoveryandbiologicalresearch.

TextBooks:1. NoTextbookispreferred,suggestedtotakeLecturer’sNotes.

ReferenceBooks:1. DNA:The Secret Life by JamesD.Watson, AndrewBerry, Publisher: AlfredAKnopf,

2003.2. Cooper, G.M. and Hausman, R.E. 2009. The Cell: A Molecular Approach. 5th edition.

ASMPress&Sunderland,Washington,D.C.;SinauerAssociates,MA3. Griffiths, A. J. F., Miller, J. H., Suzuki, D. T., Lewontin, R. C., Gelbart, W. M. An

“IntroductiontoGeneticAnalysis”,W.H.Freeman&Company,NewYork.4. LehningerPrinciplesofBiochemistry byAlbertL.Lehninger,DavidL.Nelson,Michael

M.Cox,UniversityMichaelM Cox,W.H.Freeman,20055. AutobiographiesofScientists(Articlespublishedinannualreviews)6. Brock’sbiology

https://groups.chem.ubc.ca/courseware/pH/section19/index.htmlhttp://www.bbc.co.uk/history/historic_figures/fleming_alexander.shtmlhttps://www.google.co.in/search?tbo=p&tbm=bks&q=inauthor:%22Albert+L.+Lehninger%22https://www.google.co.in/search?tbo=p&tbm=bks&q=inauthor:%22David+L.+Nelson%22https://www.google.co.in/search?tbo=p&tbm=bks&q=inauthor:%22Michael+M.+Cox%22https://www.google.co.in/search?tbo=p&tbm=bks&q=inauthor:%22Michael+M.+Cox%22https://www.google.co.in/search?tbo=p&tbm=bks&q=inauthor:%22University+Michael+M+Cox%22



6

CH1101FoundationCourseforMathematics(GroupB)(L-T-P-C:2-0-0-2)

Unit 1:BasicMathematicsBasic algebraic rules, Function, Exponential and logarithmic function, Solving quadraticequation,Basicgeometry,TrigonometryUnit 2:DifferentialCalculusBasic concepts of a limit, Continuity and differentiability of function of one and severalvariables, Rules of differentiation (Without proof), Derivative of implicit functions,Derivative of parametric functions, Indeterminate forms, Applications of Derivatives:Increasing&decreasingfunctions,maximaandminima,concavity&convexityofafunctionUnit 3:IntegralCalculusStandard integration formulae, integration by themethod of substitution, Integration byparts, Integration by the method of partial fractions, properties of definite integrals(Withoutproof),Evaluationofdefiniteintegrals,AreaunderacurveasadefiniteintegralUnit 4:DifferentialEquationsFormulationofordinarydifferentialequations,DegreeandorderofODE,FirstorderODE,Variable separation method, Homogeneous and linear first order ODE, Applications:GrowthandDecayproblem,Chemicalreactions

ReferenceBooks:1. ThecalculuswithAnalyticalGeometrybyLouisLeithold,1981.2. Differentialcalculusbyshantynarayan,1996.3. Thomas'Calculus,13thEdition,GeorgeB.Thomas,Jr.,MauriceD.Weir,JoelR.Hass.4. IntroductiontocalculusbyV.M.Shah,1980.5. CalculusandAnalyticalgeometrybyG.B.ThomasJrandFinneyF.L.



7

CH1102 BasicPhysicsI (L-T-P-C:3-1-0-4)

Unit 1:VectorPhysicsIntroductiontoScalarandVectors,DotandCrossProducts,TripleProductsandItsPhysicalInterpretation, ∇ Operator, Vector Operations: Gradient, Divergence and Curl, TheirPhysicalInterpretation,Gauss'DivergenceTheorem,StokesTheorem,Problems.Unit 2:MotionandCentralForceMotion under a central force, Conservation of angular momentum, Kepler’s laws,Gravitational Field and potential due to spherical bodies, Gauss and Poisson equations,Gravitational self-energy, Two-bodyproblem; Reducedmass, scatteringby hard spheres,Centre of mass and laboratory reference frames, Collisions in 2D & 3D, IllustrativeproblemsfromtextbooksUnit3:SolidStatePhysicsCrystal Lattice and Translation Vectors, Unit Cell, Basis, Symmetry Operations, PointGroupsandSpaceGroups, Typesof Lattices, Simple Crystal Structures, X-rayDiffraction,Bragg’s Law, X-ray Diffraction methods: Laue method, Rotating Crystal Method, PowderMethod,ReciprocalLattice,Illustrativeexamples.Unit 4:MechanicsandContinuousMediaElastic constants of an isotropic solid, Poisson’s ratio, Relations connecting the elasticConstants, Determination of Young’s Modulus of a Material, Determination of Poisson’sratio (σ) of rubber, Dynamical method (Maxwell’s needle) of determination of thecoefficient of rigidity (η) of a wire. Bending of beam, Bending Moment, The cantilever,Determinationof‘Y’ofthematerialofacantilever– casestudy.

TextBooks:1. IntroductiontoClassicalMechanics byR.G.Takwale andP.S.Pauranik (TataMcGrew-

HillPub.Com.Ltd.)2. EngineeringphysicsbyR.K.GaurandS.L.Gupta.

ReferenceBooks:1. MechanicsbyD.S.Mathur(S.Chand&Co.Ltd.)2. MathematicalMethodsinPhysicalSciencesbyM.L.Boas



8

CH1103 BasicChemistry I (L-T-P-C:3-1-0-4)

Unit1: AtomicStructureBohr’stheory,itslimitationsandatomicspectrumofhydrogenatom.Wavemechanics:deBroglie equation, Heisenberg’s Uncertainty Principle and its significance, Schrödinger’swave equation, significance of ψ and ψ2. Quantum numbers and their significance.Normalized and orthogonal wave functions. Sign of wave functions. Radial and angularwavefunctionsforhydrogenatom.Radialandangulardistributioncurves.Shapesofs,p,dand f orbitals. Contour boundary and probability diagrams. Pauli’s Exclusion Principle,Hund’s rule ofmaximummultiplicity, Aufbau’s principle and its limitations, Variation oforbitalenergywithatomicnumber.Unit 2:PrinciplesofVolumetricAnalysisAcidsandbases:Moderntheoryof acidsandbases– Bronsted–LowryconceptandLewisconcept, factors that influence the strengthof acidsandbases.DefinitionofpHandpKa.Buffers – mechanism of buffer action – Henderson – Hasselbach equations. (problemsalso)- Hydrolysisofsalts– neutralization.Hydrolysisofsaltsofstrongacidandweakbaseandsaltofweakacidandstrongbase- derivationofKa,KbandKwandproblems.RedoxReactions: Oxidationandreductionreactions– oxidationnumberconcept,balancingredoxequationsbyoxidationnumbermethodandionelectronmethod– equivalentweightofoxidizingandreducingagents.Mole concept,Equivalentweight, atomicweight,molecularweight, concentration terms -ppm, mole fraction, normality, molarity, molality. Principles of titrations – standardsolutions– primaryandsecondarystandards– typesoftitrimetricanalysis– neutralization,redox, precipitation titrations. Indicators - neutralization –redox indicator, universalindicators.Unit 3: GaseousStateKineticmolecularmodel of a gas: postulates and derivation of the kinetic gas equation;collision frequency; collision diameter; mean free path and viscosity of gases, includingtheir temperature and pressure dependence, relation between mean free path andcoefficientofviscosity,calculationofσfromη;variationofviscositywithtemperatureandpressure.Maxwelldistributionanditsuseinevaluatingmolecularvelocities(average,rootmean square and most probable) and average kinetic energy, law of equipartition ofenergy,degreesoffreedomandmolecularbasisofheatcapacities.Behaviourofrealgases:Deviationsfromidealgasbehaviour,compressibilityfactor,Z,andits variationwith pressure for different gases. Causes of deviation from ideal behaviour.Vander Waals equation of state, its derivation and application in explaining real gasbehaviour,mentionofotherequationsofstate(Berthelot,Dietrici);virialequationofstate;van der Waals equation expressed in virial form and calculation of Boyle temperature.IsothermsofrealgasesandtheircomparisonwithvanderWaalsisotherms,continuityofstates,criticalstate,relationbetweencriticalconstantsandvanderWaalsconstants,lawofcorrespondingstates.



9

Unit 4: BasicsofOrganicChemistryOrganicCompounds:Classification,andNomenclature,Hybridization,Shapesofmolecules,Influenceofhybridizationonbondproperties.Electronic Displacements: Inductive, electromeric, resonance and mesomericeffects,hyperconjugation and their applications; Dipolemoment; Organic acids and bases; theirrelativestrength.Homolytic and Heterolytic fission with suitable examples. Curly arrow rules, formalcharges; Electrophiles and Nucleophiles; Nucleophlicity and basicity; Types, shape andtheirrelativestabilityofCarbocations,Carbanions,FreeradicalsandCarbenes.Fischer Projection, Newmann and Sawhorse Projection formulae and theirinterconversions;Geometricalisomerism:cis–transand,syn-antiisomerismE/ZnotationswithC.I.Prules.Optical Isomerism:OpticalActivity,SpecificRotation,Chirality/Asymmetry,Enantiomers,Molecules with two or more chiral-centres, Distereoisomers, meso structures, Racemicmixtureandresolution.Relativeandabsoluteconfiguration:D/LandR/Sdesignations.

References Books:1. PrinciplesofphysicalchemistrybyPruttonandMarron.2. TextBookofPhysicalChemistrybySoniandDharmahara.3. TextBookofPhysicalChemistrybyPuriandSharma.4. TextBookofPhysicalChemistrybyK.L.Kapoor.5. OrganicChemistrybyJ.Clayden.6. StereochemistryofOrganicCompoundsbyD.Nasipuri7. StereochemistryofOrganiccompoundsbyELEliel.



10

CH1104BasicLifeSciencesI (L-T-P-C:3-0-0-3)

Unit1:Basicsoflivingorganism’sclassification.Fivekingdomclassification.Introductionandclassificationoforganismsbycellstructure(ProkaryoteandEukaryote),cytosol, compartmentalizationofeukaryoticcells,cellfractionation.Cell Membrane and Permeability: Chemical components of biological membranes,organizationandFluidMosaicModel.Unit2:Cytoskeleton and cell motility: Structure and function of microtubules, Microfilaments,Intermediatefilaments.Endoplasmicreticulum:Structure,functionincludingroleinproteinsegregation.Golgicomplex:Structure,biogenesisandfunctionsincludingroleinproteinsecretion.Unit3:Lysosomes:Vacuolesandmicrobodies:StructureandfunctionsRibosomes:Structuresandfunctionincludingroleinproteinsynthesis.Mitochondria:Structureandfunction,Genomes,biogenesis.Chloroplasts:Structureandfunction,genomes,biogenesisNucleus:Structureandfunction,chromosomesandtheirstructure.Unit4:Extracellular Matrix: Composition, molecules that mediate cell adhesion, membranereceptorsforextracellularmatrix,macromolecules,regulationofreceptorexpressionandfunction.Signaltransduction.Conceptsofcelldivisionandcelldeath.Cancer: Carcinogenesis, agents promoting carcinogenesis, characteristics and molecularbasisofcancer.

SuggestedReadings:1. Karp,G.2010.CellandMolecularBiology:ConceptsandExperiments.6thEdition.John

Wiley&Sons.Inc.2. DeRobertis,E.D.P.andDeRobertis,E.M.F.2006.CellandMolecularBiology.8th edition.

LippincottWilliamsandWilkins,Philadelphia.3. Cooper,G.M. andHausman,R.E.2009.TheCell:AMolecularApproach.5thedition. ASM

Press &Sunderland,Washington,D.C.;SinauerAssociates,MA.4. Becker,W.M.,Kleinsmith,L.J.,Hardin.J.andBertoni,G.P.2009.TheWorldoftheCell.

7th edition.PearsonBenjamin CummingsPublishing,SanFrancisco.



11

CH1105 Environmental Science (L-T-P-C:3-1-0-4)

Unit1:EcosystemsandBiodiversitya.Conceptofanecosystemb.Structureandfunctionsofanecosystemc.Producers,consumersanddecomposersd.Foodchain,foodwebsandecologicalpyramidse. Characteristic features of the following ecosystems: Forest ecosystems, Desertecosystem,Aquaticecosystems.f.Valueofbiodiversity:Consumptiveuseandproductiveuse.Unit2:NaturalResourcesDefinition,scopeandimportance.Needforpublicawareness:a.Forestresources:Usesandover-exploitation.Deforestation,miningandconstructionofdams. b.Water resources:Uses andover-utilization. Effects of over utilization of surfaceand ground (sub- surface) water. c. Mineral resources: Uses and exploitation,environmentaleffectsofextractionanduseofmineralresources.d.Foodresources:Worldfoodproblems,Effectsofmodernagriculture:byusingfertilizersandpesticides.e.Energyresources: Growing energy needs, renewable and non-renewable energy sources, use ofalternateenergysources.Unit3:EnvironmentalPollutiona.Definitionb.Causes,effectsandcontrolmeasuresfori.Airpollutionii.Waterpollutioniii.Soilpollutioniv.Noisepollution. GlobalwarmingandOzonelayerdepletion.EnvironmentalprotectionAct.c.Roleofindividualinprevention ofpollutionUnit 4:SocialIssuesandtheEnvironment1. Waterconservation,rainwaterharvestingandwatershedmanagement.2. Populationexplosionanditsimpactonenvironment.3. Environmentalandhumanhealth4. RoleofInformationTechnologyinEnvironmentalandhumanhealth.

ReferenceBooks:1. EnvironmentalStudiesbyDr.M.Satyanarayana,Dr.M.V.R.K.Narasimhacharyulu,Dr.G.

RambabuandDr.V.Viveka VardhaniPublishedbyTeluguAcademy,Hyderabad.2. EnvironmentalStudiesbyR.C.Sharma,GurbirSanghapublishedbyKalyaniPublishers.3. EnvironmentalStudiesbyPurnimaSmarathpublishedbyKalyaniPublishers.



12

CH1106 Lab1VolumetricAnalysis(L-T-P-C:0-0-4-2)

1. TitrimetricAnalysisa. Calibrationanduseofapparatusb. PreparationofsolutionsofdifferentMolarity/Normalityoftitrants2. Acid-BaseTitrationsa. Estimationofcarbonateandhydroxidepresenttogetherinmixture.b. Estimationofcarbonateandbicarbonatepresenttogetherinamixture.c. Estimationoffreealkalipresentindifferentsoaps/detergents3. Oxidation-ReductionTitrimetrya. EstimationofFe(II)andoxalicacidusingstandardizedKMnO4 solution.b. Estimationofoxalicacidandsodiumoxalateinagivenmixture.c. EstimationofFe(II)withK2Cr2O7 usinginternal(diphenylamine,anthranilicacid)and

externalindicator.

Reference:1. AText-BookofVolumetricAnalysis by HW. Schimpf.

CH1107Lab2PhysicsI (L-T-P-C:0-0-4-2)

1. Basicmeasurementtechniques(Verniercalliper,Screwgauge)2. Newton’srings3. Fullwave,HalfwaveRectifier4. Melde’sExperiment5. TheDiffractionGratingSpectrometer6. SeriesandParallelResonanceCircuit7. Refractiveindexofliquid8. Measurementofsurfacetensionofaliquidbycapillaryrisemethod

CH1108Lab3LifeSciences I(L-T-P-C:0-0-2-1)

1. Microscopy2. MitosisandtheCellCycleinOnionRoot-TipCells3. CellCountingandviability4. BloodSmearPreparationandStaining(Horizontalstainingprocedure)5. Permanentslidepreparation6. StainingofCellOrganelle(mitochondria).



13

IU1001SoftSkills I (L-T-P-C:1-0-0-0)

Unit 1: SelfAnalysisandAttitude∑ SWOTAnalysis∑ WhoamI?∑ FactorsinfluencingSelfPerception∑ Self Esteem∑ Understandingpositiveandnegativeattitudes

Unit 2: GoalSetting∑ TypesofGoals:Immediate,Shortterm,Longterm∑ StrategiestoAchieveGoals

Unit 3: Creativity∑ Outofboxthinking∑ LateralThinking∑ InnovativeThinking

Unit 4: CorporateEtiquettes∑ E-mailetiquette,Telephoneetiquette,∑ Diningetiquette,Officemeetingetiquettes,Dressetiquette

TextBooks:1. SoftSkillsforEveryonebyJeffButterfield,Cengagepublications

ReferenceBooks:1. PersonalityDevelopmentandSoftSkillsbyBarunKMitra2. LateralThinking:CreativityStepbyStepbyEdwarddeBono



14

SEMESTER- II

CH1201BasicPhysicsII (L-T-P-C:3-1-0-4)

Unit1:ThermodynamicsHeat,HeatEngine,ZerothLawofThermodynamics,FirstLawofThermodynamicsandItsLimitations, Second Law of Thermodynamics, Adiabatic, Isobaric, Isotonic Reactions,Entropy,ReversibleandIrreversibleProcess,IncreaseofEntropyConcept,Enthalpy.Unit2:PropertiesGasPostulatesofKineticTheoryofGas,DerivationofPressureandR.M.S.Velocity,DegreesofFreedom,DegreesofFreedomforMono,DiandTryAtomicMolecules,LawofEquipartitionEnergyExpression ofMean Free Path, TransportPhenomena,Derivations: Expression ofViscosity Coefficient, Expression of Thermal Conductivity, Expression of DiffusionCoefficient.Unit3:LiquefactionofGasRealGasCorrectionTermsinIdealGasEquation,VanDerWaalsModelforRealGas,CriticalConstants,Joule-ThomsonPorousPlugExperiment,CascadeCooling,Linde’sMethodofAirCooling,AdiabaticDemagnetizationMethodandDerivation,MeasurementTechniques forLowTemperatures,Refrigerator.Unit4:MaterialsScienceandNanotechnologyBand theory of solids: Introduction,Metals, InsulatorsandSemiconductors, Energybandgap, Fermi Level and Fermi energy, Types of magnetic material, Superconductivity,Properties of superconductors,Typesof superconductors (Type I andType II), London’sPenetrationdepth,ApplicationsofSuperconductors.Nanotechnology:IntroductiontoNanoScienceandNanotechnology,MethodofProducing,Properties, Physics of nonmaterial, Quantum Confinement, Synthesis of Nano Materials,ShapeMemoryAlloysandMetallicGlasses.

TextBooks:1. Brijlal,SubramaniyamN.HeatandThermodynamics,SChand&Co.Ltd,NewDelhi.2. Gupta,A.B.andRoy,H.P.HeatandThermodynamics.NewCentralBookAgencyPvt.

Ltd.,Kolkata1999.

ReferenceBooks:1. Kittel,C.IntroductiontoSolidStatePhysics,8thEd.JohnWiley&Sons.2. Pradeep,T.A.TextbookofNano scienceandNano technologyTextbook.TataMcGraw

HillEducationPrivateLimited.



15

CH1202BasicChemistryII (L-T-P-C:3-1-0-4)

Unit1: ChemicalBondingIonic bond: General characteristics, types of ions, size effects, radius ratio rule and itslimitations. Packing of ions in crystals. Born-Landé equation with derivation andimportanceofKapustinskiiexpression for latticeenergy.Madelungconstant,Born-Habercycleanditsapplication,Solvationenergy.Covalent bond: Lewis structure, Valence Bond theory (Heitler-Londonapproach).Energetics of hybridization, equivalent and non-equivalent hybrid orbitals.Bent’s rule,Resonanceand resonanceenergy,Molecularorbital theory.MolecularorbitaldiagramsofdiatomicandsimplepolyatomicmoleculesN2,O2,C2,B2,F2,CO,NO,andtheirions;HCl,BeF2,CO2,(ideaofs-pmixingandorbitalinteractiontobegiven).Formalcharge,Valenceshellelectronpairrepulsiontheory(VSEPR),shapesofsimplemoleculesandionscontaining lone pairs and bond pairs of electrons, multiple bonding (σ and π bondapproach)andbondlengths.Covalentcharacterinioniccompounds,polarizingpowerandpolarizability.Fajan’srulesandconsequencesofpolarization.Ionic character in covalent compounds: Bond moment and dipole moment. Percentageioniccharacterfromdipolemomentandelectronegativitydifference.Metallic Bond: Qualitative idea of valence bond and band theories. Semiconductors andinsulators,defectsinsolids.WeakChemicalForces:vanderWaalsforces,ion-dipoleforces,dipole-dipole interactions,induced dipole interactions, Instantaneous dipole-induced dipole interactions. Repulsiveforces,Hydrogenbonding(theoriesofhydrogenbonding,valencebondtreatment)Effectsofchemicalforce,meltingandboilingpoints,solubilityenergeticsofdissolutionprocess.Unit2: LiquidandSolidStatePhysicalpropertiesofliquids:Vapourpressure,surfacetensionandcoefficientofviscosity,and their determination. Effect of addition of various solutes on surface tension andviscosity.Explanationofcleansingactionofdetergents.Temperaturevariationofviscosityofliquidsandcomparisonwiththatofgases.Nature of the solid state, law of constancy of interfacial angles, law of rational indices,Miller indices, elementary ideas of symmetry, symmetry elements and symmetryoperations,qualitativeideaofpointandspacegroups,sevencrystalsystemsandfourteenBravaislattices;X-raydiffraction,Bragg’slaw,asimpleaccountofrotatingcrystalmethodandpowderpatternmethod.Defectsincrystalsandliquidcrystals.Unit3: IonicEquilibriumStrong,moderate andweak electrolytes, degree of ionization, factors affecting degree ofionization, ionization constant and ionic product ofwater. Ionization ofweak acids andbases,pHscale,commonioneffect;dissociationconstantsofmono-,di-andtriproticacids(exacttreatment).Salthydrolysis-calculationofhydrolysisconstant,degreeofhydrolysisandpHfordifferentsalts. Buffer solutions; derivation of Henderson equation and its applications; buffercapacity,bufferrange,bufferactionandapplicationsofbuffersinanalyticalchemistryandbiochemicalprocessesinthehumanbody.



16

Solubility and solubility product of sparingly soluble salts – applications of solubilityproductprinciple.Qualitativetreatmentofacid– basetitrationcurves(calculationofpHatvarious stages). Theory of acid–base indicators; selection of indicators and theirlimitations.Multistageequilibriainpolyelectrolytesystems;hydrolysisandhydrolysisconstants.Unit4: BasicsofOrganicChemistryIntroductiontotypesoforganicreactionsandtheirmechanism:Addition,EliminationandSubstitutionreactions.ChemistryofAliphaticHydrocarbons,Carbon-CarbonsigmabondsChemistryofalkanes:Formationofalkanes,WurtzReaction,Wurtz-FittigReactions,Freeradicalsubstitutions:Halogenation-relativereactivityandselectivity.Carbon-Carbon pi bonds: Formation of alkenes and alkynes by elimination reactions,MechanismofE1,E2,E1cbreactions.SaytzeffandHofmanneliminations.Reactions of alkenes: Electrophilic additions their mechanisms (Markownikoff/ AntiMarkownikoff addition), mechanism of oxymercuration-demercuration, hydroboration-oxidation, ozonolysis, reduction (catalytic and chemical), syn and anti-hydroxylation(oxidation).1,2-and1,4-additionreactionsinconjugateddienesand,Diels-Alderreaction;Allylic and benzylicbromination and mechanism, e.g. propene, 1-butene, toluene, ethylbenzene.Reactionsofalkynes:Acidity,ElectrophilicandNucleophilicadditions.Hydration to formcarbonylcompounds,Alkylationofterminalalkynes

ReferenceBooks:1. PhysicalchemistrybyGurudeepChatwal.2. TextBookofPhysicalChemistrybySoniandDharmahara.3. TextBookofPhysicalChemistrybyPuriandSharma.4. TextbookoforganicchemistrybyMorrisonandBoyd.5. ATextBookofOrganicChemistrybyBahlandArunBahl.



17

CH1203BasicLifeSciences II (L-T-P-C:3-1-0-4)

Unit1:Fundamentals, History and Evolution of Microbiology. Classification of microorganisms:Microbial taxonomy, criteria used including molecular approaches, Microbial phylogenyandcurrentclassificationofbacteria.MicrobialDiversity:DistributionandcharacterizationProkaryotic and Eukaryotic cells, Morphology and cell structure of major groups ofmicroorganisms eg. Bacteria, Algae, Fungi, Protozoa, Archaea and Unique features ofviruses.Unit 2: BasicTechniquesofMicrobiologyNutritional categories of micro-organisms, methods of isolation, Purification andpreservation.Unit3: MicrobialgrowthGrowthcurve,Generation time,synchronousbatchandcontinuousculture,measurementofgrowthandfactorsaffectinggrowthofbacteria.Gene transfer: Transformation, Transduction and Conjugation. Bacterial differentiation-Endosporeandsporulation.Unit4:ControlofMicroorganismsBy physical, chemical and chemotherapeutic Agents Water Microbiology: Bacterialpollutants of water, coliforms and non coliforms. Sewage composition and its disposal.Food Microbiology: Important microorganism in food Microbiology: Moulds, Yeasts,bacteria. Major food born infections and intoxications, Preservation of various types offoods.FermentedFoods.

SuggestedReadings:1. Alexopoulos CJ, Mims CW, and Blackwell M. (1996). Introductory Mycology. 4 th

edition.JohnandSons,Inc.2. Jay JM, Loessner MJ and Golden DA. (2005). Modern FoodMicrobiology. 7thedition,

CBSPublishersandDistributors,Delhi,India.3. KumarHD.(1990).IntroductoryPhycology.2ndedition.AffiliatedEastWesternPress.4. MadiganMT,MartinkoJMandParkerJ.(2009).BrockBiologyofMicroorganisms.12th

edition.Pearson/BenjaminCummings.5. Pelczar MJ, Chan ECS and Krieg NR. (1993). Microbiology. 5th edition. McGraw Hill

BookCompany.6. StanierRY,IngrahamJL,WheelisML,andPainterPR.(2005).General Microbiology.5th

edition.McMillan.7. TortoraGJ,FunkeBR,andCaseCL.(2008).Microbiology:AnIntroduction.9thedition.

PearsonEducation.8. Willey JM, Sherwood LM, and Woolverton CJ. (2008). Prescott, Harley and Klein’s

Microbiology.7thedition.McGrawHillHigherEducation



18

CH1 204MathematicsandStatistics (L-T-P-C:3-1-0-4)

Unit1:IntroductiontoMatricesAddition and multiplication of Matrices, special types of matrices and their properties.Determinantofmatricesoforder2,3and4,inverseofamatrix,Cayley- Hamiltontheorem(Withoutproof)&Characteristicvalues.Unit2:ElementaryoperationsofMatricesElementary operations and Elementary matrices, Rank of a matrix, Invariance of rankunderelementaryoperations,Rowreducedechelonformofamatrix,homogenousandNon–homogeneoussystemoflinearequations,Cramer’srule.Unit 3: ReorientationDefinition ofprobability, Exhaustive events, Pairwise independent events,Multiplicativelawofprobability,Conditionalprobability, Baye’stheoremProbability Distributions: Random variable,Mathematical Expectation, Binomial, PoissonandNormaldistributions.Unit 4:StatisticsDescriptiveStatistics:Mean,Median,Mode,Standarddeviation,SkewnessCurve Fitting: Fitting of Linear, Quadratic, Exponential and Logarithmic curves, LeastsquaresmethodCorrelation and Regression: Bivariate distribution, Correlation coefficients, Regressionlines,FormulasforRegressioncoefficients,Rankcorrelation

Suggestedbooks:1. E.Kreyszig,AdvancedEngineeringMathematics(8thEdition),JohnWiley(1999)2. MatricesbyJ.N.KapurandM.K.Singal.3. AnintroductiontolinearalgebrabyV.Krishnamurthy,V.P.MainraandJ.L.Arora.4. AtextbookofmatricesbyShantinarayanandR.K.Mittal.5. ProbabilityandStatisticsbyJohnsonRichardA.,MillerandFreund's- (8thEdition).6. Gupta,S.P.,StatisticalMethods,SultanChandandSons,NewDelhi



19

CH1205Communication Skills I (L-T-P-C:1-1-0-2)

Unit1:CommunicationSkillsImportance of Communication Skills, Communication Cycle, Types, Flows, Barriers, Non-verbalcommunicationUnit2:ListeningskillsTypesofListening,BarrierstoEffectiveListening,TipstoimproveListeningSkillsUnit3:GrammarArticles,Prepositions,Tenses,Concord,Adjectives&degreesofComparison,AdverbsUnit4:SpeakingSkillsImpromptu,Shortsituationaldialogues/conversation,Shortspeeches,PresentationsUnit5:ReadingSkillsDifference between Skimming& Scanning, identifyingmain idea and topic, guessing themeaningsofwords

TextBooks:1. “CommunicationSkills’,- Dr. SanjayKumarandDr. PushpLata,OxfordUniversityPress2. “Technical Communication; Principles and Practice” – Meenakshi Raman & Sangita

Sharma(OxfordUniversityPress.

ReferenceBooks:1. “EffectiveTechnicalCommunication”-MAshrafRizvi2. “TextBookofCommunicationSkills”– VitthalPatel&UnnatPatel,RiaPublishingHouse3. “HighSchoolEnglishGrammar”–Wren&Martin4. “CommunicationSkills”–AshaKaul,TataMcGrawHill,2nd Ed.Note:TutorialsviaLanguageLabsessionswillbebasedontheabovecourse.



20

CH1206Lab4 OrganicandPhysicalChemistry (L-T-P-C:0-0-4-2)

1. Checkingthecalibrationofthethermometer2. Purificationoforganiccompoundsbycrystallization,distillationandsublimation.3. Determination of the melting points of above compounds and unknown organic

compounds(electricallyheatedmeltingpointapparatus)4. Effectofimpuritiesonthemeltingpoint– mixedmeltingpointoftwounknownorganic

compounds5. Surfacetensionmeasurements.

Determinethesurfacetensionby(i)dropnumber(ii)dropweightmethod.Studythevariationofsurfacetensionofdetergentsolutionswithconcentration.

6. ViscositymeasurementusingOstwald’sviscometer.Determination of viscosity of aqueous solutions of (i) polymer (ii) ethanol and (iii)sugaratroomtemperature.Studythevariationofviscosityofsucrosesolutionwiththeconcentrationof solute.

ReferenceBooks:1. B.D.Khosla,SeniorPracticalPhysicalChemistry,R.Chand&Co.2. A.I.Vogel:TextbookofPracticalOrganicChemistry,5thedition,PrenticeHall.3. F.G.Mann&B.C.Saunders,PracticalOrganicChemistry,OrientLongman(2001).

CH1207Lab5PhysicsII (L-T-P-C:0-0-4-2)

1. p-nJunctionCharacteristics2. LogicGates3. e/mratiobyThomson’sMethod4. specificrotationofsugarsolution5. HallEffectanditsmeasurement6. NumericalapertureofFiberoptics7. StudyofaTransformer8. StudyofmagneticfieldofSolenoid

CH1208Lab6LifeSciencesII (L-T-P-C:0-0-4-2)

1. Preparationofmedia.2. Isolationofcoliformbacteriafromwastewaterandtheiridentification.3. IsolationofBacillus spp.fromsoilsample.4. Stainingmethods:Monochromestaining,Gram’sstaining,Capsulestaining.5. EffectofUVradiationonpigmentproductionofSerratiamarcescens.



21

SEMESTER- III

CH2 101 BasicPhysicsIII (L-T-P-C:3-0-0-3)

Unit1:OpticsInterference,TypesofInterference,Fresnel’sbiprism,WhiteLightFringes,Determinationofthethicknessofathinsheetoftransparentmaterial,interferenceinthinfilms,Newton’srings, Michelson interferometer, Febry-Perot interferometer, Diffraction and its types,Franhoferdiffractionatacircularaperture,Planediffractiongrating,dispersivepowerofgrating,Resolvingpowerofgrating,Prism,TelescopeandMicroscopeUnit2:WavesTypesofwaves,Waveequationdevelopment:Stringcase,Idealstringconstraints,Solutionof Stringwave,Travellingwave solution for string, Energy inwavemotion,Wave speed,speedofsoundinair: Newton’sformula,Laplacecorrection.Unit3:ResolvingPowerRayleigh’s criterion, Resolving power of optical instrument : Telescope and Microscope,Relation between resolving power and magnifying power, Resolving power of a planediffraction grating, Huygen’s and Ramsden’s eye-piece. Polarization: Polarization byscattering and by selective Absorption Double refraction, Huygen’s theory of doublerefraction, Nicol’s prism, Production and detection of plane, elliptically and circularlypolarizedlights.Unit4:LasersAttenuation of light in an opticalmedium,Thermal equilibrium, Interactionof lightwithmatter, Absorption, Spontaneous emission, Einstein’s prediction, Stimulated emission,Einstein relations, Light amplification, condition for stimulated emission to dominatespontaneous emission and absorption, population inversion, active medium, pumpingmethods,meta-stable states, principle of pumping schemes-three and four level scheme,opticalresonantcavity,lasingaction,He-NeLaser,P-NJunctionLaser.

ReferenceBooks:1. ATextbookofOptics,N.SubrahmanyamBrijlal,M.N.Avadhanulu(S.Chand&Co.Ltd.)2. Optics– AjayGhatak,TMHEdition3. Atextbookonoscillations,waves&AcousticsbyM.Ghosh,D.Bhattacharya(S.Chand)4. Mechanics, Wave motion & Heat by Francis Weston Sears (Addision Wesley

Publication)



22

CH2 102StereochemistryofCycloalkanes,ConformationalAnalysisandAromaticity(L-T-P-C:3-0-0-3)

Unit1: IntroductiontoStereochemistryFischer Projection, Newmann and Sawhorse Projection formulae and theirinterconversions;Geometricalisomerism:cis–transand,syn-antiisomerismE/ZnotationswithC.I.Prules.Unit2:OpticalIsomerismOpticalActivity,SpecificRotation,Chirality/Asymmetry,Enantiomers,Moleculeswith twoormorechiral-centres,Distereoisomers,mesostructures,Racemicmixtureandresolution.Relativeandabsoluteconfiguration:D/LandR/Sdesignations.Unit3:Stereochemistry of CycloalkanesandConformationalAnalysisTypes of cycloalkanes and their relative stability, Baeyer strain theory, Conformationanalysis of alkanes: Relative stability: Energy diagrams of cyclohexane: Chair, Boat andTwistboatforms;Relativestabilitywithenergydiagrams.Unit4:Stereochemistry of AromaticHydrocarbonsAromaticity: Hückel’s rule, aromatic character of arenes, cyclic carbocations/carbanionsandheterocyclic compounds with suitable examples. Electrophilic aromatic substitution:halogenation, nitration, sulphonation and Friedel-Craft’s alkylation/acylation with theirmechanism.Directingeffectsofthegroups.

ReferenceBooks:1. StereochemistryoforganiccompoundsE.L.Eliel.2. IntroductiontostereochemistryByKurtMislow3. StereochemistryoforganiccompoundsD.Nasipuri.4. Stereochemistry:ConformationandmechanismP.S.Kalsi.



23

CH2 103ChemicalThermodynamics (L-T-P-C:3-0-0-3)

Unit1:IntroductiontoChemicalThermodynamicsIntensive and extensive variables; state and path functions; isolated, closed and opensystems;zerothlawofthermodynamics.First law: Concept of heat, q, work, w, internal energy, U, and statement of first law;enthalpy,H,relationbetweenheatcapacities,calculationsofq,w,UandHforreversible,irreversibleand freeexpansionofgases(idealandvander Waals)underisothermalandadiabaticconditions.Unit2:ThermochemistryHeats of reactions: standard states; enthalpy of formation of molecules and ions andenthalpyofcombustionanditsapplications;calculationofbondenergy,bonddissociationenergyandresonanceenergyfromthermochemicaldata,effectoftemperature(Kirchhoff’sequations)andpressureonenthalpyofreactions.Adiabaticflametemperature,explosiontemperature.Second Law: Concept of entropy; thermodynamic scale of temperature, statement of thesecond law of thermodynamics; molecular and statistical interpretation of entropy.Calculationofentropychangeforreversibleandirreversibleprocesses.Third Law: Statement of third law, concept of residual entropy, calculation of absoluteentropyofmolecules.Unit3:FreeEnergyFunctionsGibbs and Helmholtz energy; variation of S, G, A with T, V, P; Free energy change andspontaneity. Relation between Joule-Thomson coefficient and other thermodynamicparameters; inversion temperature; Gibbs-Helmholtz equation; Maxwell relations;thermodynamicequationofstate.Partial molar quantities, dependence of thermodynamic parameters on composition;Gibbs-Duhem equation, chemical potential of ideal mixtures, change in thermodynamicfunctionsin mixingofidealgases.

ReferenceBooks:1. ChemicalengineeringThermodynamicsbyM.J.Smith.2. AtextbookofChemicalengineeringThermodynamicsByKVNarayanan.3. EngineeringThermodynamicsByP.K.Nag.4. FundamentalsofEngineeringThermodynamicsByMoranM.JandShapiro.



24

CH2 104Lifesciences III(L-T-P-C:3-0-0-3)

Unit1: DNAReplicationDNA Replication in prokaryotes and eukaryotes. Stages in DNA replication- initiation,elongationandtermination.EnzymesandproteinsinvolvedinDNAreplication.DNArepairmechanism.DrugsthatinhibitDNAreplication.Mutagenesis,Mutations,andMutants- Terminology,TypesofMutations,BiochemicalBasisofMutantsandmutagenesisUnit2:TranscriptionIntroduction to transcription, RNA polymerases, Promoter, terminator and otherregulatory elements. Process of transcription; Initiation, elongation and termination,Transcription inhibitors (Rifampicin, Actinomycin D and α-Amanitin). Types of RNA;mRNA,rRNAandtRNA.PosttranscriptionalmodificationsofRNA.Unit3:TranslationGeneticcodon,Structureandassemblyofeukaryoticandprokaryoticribosomes,peptidyltransferaseandaminoacyltRNAsynthetases. Processof translation; Initiation,elongationandtermination,Posttranslationalmodification.Translationinhibitors(Chloramphenicol,Tetracyclin,Ricin,NeomycinandPuromycinetc.)Unit4:RecombinantDNATechnologyExtractionandPurificationofnucleicacids,DetectionandQuantitationofNucleicacids,GelElectrophoresis. Vectors for Gene Cloning- plasmids, ColEI bacteriophages, cosmids, BACandYAC. RestrictionEndonucleases, Ligases, Endmodification enzymesetc., Selection ofrecombinants. PCR : basic features and application. Application of recombinant DNAtechnology,BasicstepsinvolvedinRDT,BasicPCRanditsapplications.

SuggestedReadings:1. AlbertsB,BrayD,LewisJ,RaffM,RobertsK,andWatsonJ.D.“MolecularBiologyofthe

Cell”.GarlandScience.2. WatsonJ.D,BakerT.A,BellS.P,GannA,LevineMandLosickR.”MolecularBiologyofthe

Gene”..Benjamin-CumminsPublishingCo.,3. T.A. Brown,GeneCloningandDNAAnalysis:AnIntroduction,7th Ed.,WileyBlakwell

publication4. LewinB.“Genes”.Jones&BartlettPublishers

https://en.wikipedia.org/wiki/Rifampicin



25

CH2 105IndustrialChemistry (L-T-P-C:2-0-0-2)

Unit1:SilicateIndustriesGlass: Glassy state and its properties, classification (silicate and non-silicateglasses).Manufactureandprocessingofglass.Compositionandpropertiesofthefollowingtypesofglasses:Sodalimeglass,leadglass,armouredglass,safetyglass,borosilicateglass,fluorosilicate,colouredglass.Cements:Classificationofcement, ingredientsand their role,Manufactureofcementandthesettingprocess,quicksettingcements.Unit2:FertilizersDifferent types of fertilizers. Manufacture of the following fertilizers: Urea, ammoniumnitrate,calciumammoniumnitrate,ammoniumphosphates;polyphosphate.Unit3:BatteriesPrimary and secondary batteries, battery components and their role, Characteristics ofBattery.Working of following batteries: Pb acid, Li-Battery, Solid state electrolytebattery.Fuelcells,Solarcellandpolymercell.Unit4:AlloysClassification of alloys, ferrousandnon-ferrous alloys, Specific properties of elements inalloys. Manufacture of Steel (removal of silicon decarbonization, demanganization,desulphurization dephosphorisation) and surface treatment (argon treatment, heattreatment,nitriding,carburizing).Compositionandpropertiesofdifferenttypesofsteels.

Reference Books:1. E.Stocchi:IndustrialChemistry,Vol-I,,EllisHorwoodLtd.UK.2. R. M. Felder, R. W. Rousseau: Elementary Principles of Chemical Processes, Wiley

Publishers,NewDelhi.3. W.D.Kingery,H.K.Bowen,D.R.Uhlmann:IntroductiontoCeramics,WileyPublishers,

NewDelhi.4. J.A.Kent:RiegelsHandbookofIndustrialChemistry,CBSPublishers,NewDelhi.5. P.C.Jain,M.Jain:EngineeringChemistry,DhanpatRai&Sons,Delhi.6. R.Gopalan,D.Venkappayya,S.Nagarajan:EngineeringChemistry,VikasPublications,

NewDelhi.7. B.K.Sharma:EngineeringChemistry,GoelPublishingHouse,Meerut



26

CH2 106Seminar &SoftskillsII (L-T-P-C:1-0-0-1)

Unit1:InterpersonalSkills∑ UnderstandingProfessionalRelationship∑ RespectingSocialProtocols∑ HandlingSocialMedia∑ ShowingBasicsOfficeCourtesies∑ ImageBuilding

Unit2:PersonalSkills∑ BodyLanguage∑ TimeManagement∑ NegotiationSkills∑ PersuasionSkill

Unit3:MakingEffectivePresentations∑ Patterns&MethodsofPresentation,OralPresentation:Planning&Preparation∑ Tolearntheskillofpresentation,Howtopreparethepresentation,∑ Knowingtheaudienceandtheirrequirements∑ Effectivewaystodeliverpresentation∑ Howtopreparemulti-mediapresentation

Unit4:GroupDiscussions∑ Purpose(IntellectualAbility,Creativity,Approachto aProblem,Solving,Tolerance)∑ GroupBehavior∑ AnalyzingPerformance

TextBooks:1. SoftSkillsforEveryonebyJeffButterfield,Cengagepublications

ReferenceBooks:1. PersonalityDevelopmentandSoftSkillsbyBarunKMitra2. LateralThinking:CreativityStepbyStepbyEdwarddeBono3. TeachYourselftoThinkbyEdwarddeBono4. SixThinkingHatsbyEdwarddeBono



27

CH2 107Lab7OrganicQualitativeAnalysis (L-T-P-C:0-0-8-4)

1. QualitativeanalysisofSingleOrganicCompoundatleastonebelongingfromeachtype2. Type,Preliminarytests,elements,functionalgroup.Physicalconstants.a. BenzoicAcid,SalicyclicAcid,CinnamicAcid,PhthalicAcidandOxalicacidb. Beta-Naphthol,Alpha-Naphtholc. Aniline,N-methylaniline,N,N-Demethylanilined. Naphtalene,thiourea,Urea,m-Dinitrobenzene,chloroform,ethylmethylketone,ethyl

acetate,chlorobenzene3. ThinLayerchromatography,columnchromatography

Reference Books:1. A.I.Vogel:TextbookofPracticalOrganicChemistry,5thedition,PrenticeHall.2. F.G.Mann&B.C.Saunders,PracticalOrganicChemistry,OrientLongman(2001)

CH2 108Lab8PhysicsIII (L-T-P-C:0-0-4-2)

1. Diffractiongrating2. Cauchy’sconstants3. Fresnel’sbi-prism4. Thermalconductivityofglass5. ThermalconductivitybyLee’sdiscmethod6. Stefan’sconstantusingfilamentlamp7. Magneticfieldalongsolenoidaxis8. Magnetichysteresis9. RigiditybyMaxwell’sneedlemethod10. Rigiditybystatistical method

CH2 109 Lab9LifeSciencesIII (L-T-P-C:0-0-4-2)1. EstimationofDNAbyDPAmethod2. EstimationofRNAbyorcinolmethod3. EstimationofproteinbyFolinLowryandBradford’smethod4. IsolationandextractionofDNAfrombacterialcultureusingchloroform:isoamyl

alcoholmethod5. Qualitative analysisofDNA6. IsolationandextractionofplasmidDNA

IU2 000CommunityConnectProject(L-T-P-C:1-0-0-1)



28

SEMESTER-IV

CH2 201PhysicsIV (L-T-P-C:3-0-0-3)

Unit1:NuclearChemistryStructure of atomic nucleus, Segre Chart, Instability of nucleus, Radioactivity, Decayconstant and half-life, isotopes, isotones, simple nuclear reactions, “ideal, transient andsecularequilibrium”,Qvalueofnuclearreactions,Thresholdenergyofnuclearreactions,Energy difference in Chemical and nuclear reaction, Nuclear fission, Nuclear reactor,Nuclearfusion,Energyproductioninstars,Illustrativeexamples.Unit 2:ElectronicsSemiconductors,Intrinsicandextrinsicsemiconductorstructure,PNJunctiondiode,FBandRB condition for PN junction and IV characteristics, LED, Half wave-full wave rectifier,Photodiode, Varactor Diode, Filter circuits: L, C and Π type filters, Transistor, IVcharacteristics of CE mode, Binary-octal-hex decimal number system and mutualconversions,IllustrativeexamplesUnit 3:Electricity&MagnetismGauss’Lawintegrationanddifferentialform,PoissonandLaplaceequation,ApplicationofGauss’ Law – chare on sphere all cases; charge in hollow sphere all cases, Charging anddischargingofLRandLCcircuitsMagnetic field andunits,Motion of charge inmagnetic field,Magnetic Susceptibility andtypesofmaterialonthebasesofitsvalue.Hysteresis.Unit4:ModernPhysicsMillikan'soildropexperimentforelectroniccharge,Determinationofq/mofpositiverays,Astonmass spectrograph.XRaysproduction,originandproperties,diffractionofX rays,Bragg’s law, Moseley’s law. Wave behaviour of particles; De Broglie wave length wavepackets and particles; Heinsenberg's uncertainty relation; Wave function; PhysicalinterpretationoftrappedparticlesandProbabilitydensities.

ReferenceBooks:1. NuclearPhysics– Anintroduction,S.B.Patel,NewAgeInternationalLimited.2. PrinciplesofElectronics,V.K.Mehta(S.Chand&Co.Ltd.).3. ElectricityandMagnetismwithElectronics,K.K.Tewari(S.chand&Co.Ltd.).4. ModernphysicsbyGAruldhasandPRajgopal5. ModernphysicsbyDSehgal,KChopraandNSehgal(SChandandCo,NewDelhi)6. Fundamentals of modern physics by J P Agrawal and A Agrawal Pragati Prakashan

(Meerut)7. ConceptsofModernPhysicsbyBieser(TataMcGraw-Hill)



29

CH2 202PeriodicityofElements,Chemistryofs andp BlockElements,NobleGases(L-T-P-C:3-0-0-3)

Unit1:PeriodicityofElementss,p,d,fblockelements,thelongformofperiodictable.Detaileddiscussionofthefollowingpropertiesoftheelements,withreferencetos & p-block.(a) Effectivenuclearcharge,shieldingorscreeningeffect,Slaterrules,variationofeffectivenuclearchargeinperiodictable.(b)Atomicradii(vanderWaals)(c) Ionicandcrystalradii.(d)Covalentradii(octahedralandtetrahedral)(e) Ionizationenthalpy,Successiveionizationenthalpiesandfactorsaffectingionizationenergy.Applicationsofionizationenthalpy.(f) Electrongainenthalpy,trendsofelectrongainenthalpy.(g) Electronegativity, Pauling’s/ Mulliken’s/ Allred Rachow’s/ and Mulliken-Jaffé’selectronegativity scales. Variation of electronegativity with bond order, partial charge,hybridization,groupelectronegativity.Sanderson’selectrondensityratio.Unit2:Chemistryofsandp BlockElementsInertpair effect, Relative stability ofdifferent oxidation states, diagonal relationship andanomalous behaviour of first member of each group. Allotropy and catenation.Complexformation tendencyofsandpblockelements.Hydridesandtheirclassificationionic,covalentandinterstitial.Basicberylliumacetateandnitrate.Study of the following compounds with emphasis on structure, bonding, preparation,propertiesanduses.Boricacidandborates,boronnitrides,borohydrides(diborane)carboranesandgraphiticcompounds, silanes, Oxides and oxoacids of nitrogen, Phosphorus and chlorine. Peroxoacids of sulphur, interhalogen compounds, polyhalide ions, pseudohalogens and basicpropertiesofhalogens.

Reference Books:1. PrinciplesofInorganicChemistrybyPuri,SharmaandKaliaVishalPublications1996.2. ConciseInorganicChemistrybyJ.D.Lee3rdEd.3. BasicInorganicChemistrybyF.A. Cotton,G. WilkinsonandPaul. L.Gaus3rdEd. Wiley

Publishers2001.Chem.4. InorganicChemistryPrinciplesofstructureandreactivitybyJamesE. Huhey5. SelectedtopicsinInorganicChemistrybyMadan,MalikandTuli.



30

CH2 203ChemicalKinetics,CatalysisandChemicalEquilibrium(L-T-P-C:3-0-0-3)

Unit1:ChemicalKineticsOrderandmolecularityofareaction,ratelawsintermsoftheadvancementofareaction,differential and integrated form of rate expressions up to second order reactions,experimental methods of the determination of rate laws, kinetics of complex reactions(integrated rate expressions up to first order only): (i) Opposing reactions (ii) parallelreactionsand(iii)consecutivereactionsandtheirdifferentialrateequations(steady-stateapproximationinreactionmechanisms)(iv)chainreactions.Temperature dependence of reaction rates; Arrhenius equation; activation energy.Collision theory of reaction rates, Lindemann mechanism, qualitative treatment of thetheoryofabsolutereactionrates.Unit2:CatalysisTypes of catalyst, specificity and selectivity, mechanisms of catalyzed reactions at solidsurfaces; effect of particle size and efficiency of nanoparticles as catalysts. Enzymecatalysis,Michaelis-Mentenmechanism,acid-basecatalysis.Unit2:ChemicalEquilibriumCriteria of thermodynamic equilibrium, degree of advancement of reaction, chemicalequilibria in ideal gases, concept of fugacity. Thermodynamic derivation of relationbetween Gibbs free energy of reaction and reaction quotient. Coupling of exergonic andendergonic reactions. Equilibrium constants and their quantitative dependence ontemperature, pressure and concentration. Free energy of mixing and spontaneity;thermodynamicderivation of relations between the variousequilibrium constantsKp ,Kcand Kx. Le Chatelier principle (quantitative treatment); equilibrium between ideal gasesandapurecondensedphase.

Reference Books:1. ChemicalKineticsbyK.J.Laidler2. Chemical Kinetic Methods–Principles of Relaxation techniques & Applications by C.

Kalidas.



31

CH2 204LifeSciencesIV (L-T-P-C:3-0-0-3)

Unit1:CellsandOrgansofImmuneSystem(a)Lymphocytesasmainactors;Typesof lymphocytes,B cells,T cells andNull cells. (b)Importanceofantigenpresentingcells in IR. (c)An introduction to theprimary(central)and secondary (peripheral) lymphoid organs. Antigens, Antibodies and their Reaction,Antigens, Concept of antigen, immunogen and hapten, Physico-chemical and biologicalpropertiesofantigens,Various typesofantigens,Antigensoccurring inbacterial cell. (b)Antibodies- Conceptofantibody,immunoglobulinandmyelomaproteins,Basicstructureofantibodies,Classesofimmunoglobulins;Physicochemicalandbiologicalproperties,ClonalselectionandAntibodydiversity.Unit2:ImmunityanditsTypes(a) Immunity - Concept of innate (native) and acquired (adaptive) immunity, Types ofimmunity, Innate immunity:species, racialandindividual,Acquiredimmunity:activeandpassive; natural and artificial, Concept of herd immunity. (b) Immune response (IR)-ConceptandbasicfunctionsofIR,twoarms(branches)ofIR:Antibodymediated(humoral)andcellmediatedimmune(CMI),CharacteristicsofIR:Discrimination,diversity,specificity,memoryandtransferability.(c)PrimaryandsecondaryIRUnit3:Antigen-AntibodyReactions(a) Mechanism of antigen-antibody reactions (zone phenomenon); Concept of latticeformation. (b) Principles and applications antigen-antibody reactions, Precipitationreaction, Agglutination reaction, Complement fixation reaction, Immunofluorescence,EnzymeLinkedImmunosorbantAssay(ELISA),RadioImmunoassay(RIA);Radio-Allergo-Sorbenttest(RAST),Westernblottechnique.(C)VariousskintestsUnit4:ImmuneDisorders(a)Conceptofhyperandhypo functioningofimmunesystem.(b)Typesimmunedisorder-Hypersensitivity, Autoimmunity and autoimmune disorders. (c) Immunodeficiency. (d)Transplantationimmunity,conceptofimmunesuppression.(e)MHCandit’simportance

SuggestedReadings:1. Abbas AK, Lichtman AH, Pillai S. (2007). Cellular and Molecular Immunology. 6 th

editionSaundersPublication,Philadelphia.2. Delves P, Martin S, Burton D, Roitt IM. (2006). Roitt’s Essential Immunology. 11th

editionWiley-BlackwellScientificPublication, Oxford.3. Goldsby RA, Kindt TJ, Osborne BA. (2007). Kuby’s Immunology. 6th edition W.H.

FreemanandCompany,NewYork.4. Murphy K, Travers P, Walport M. (2008). Janeway’s Immunobiology. 7th edition

GarlandSciencePublishers,NewYork.5. Peakman M, and Vergani D. (2009). Basic and Clinical Immunology. 2nd edition

ChurchillLivingstonePublishers,Edinberg.6. RichardCandGeiffreyS.(2009).Immunology.6thedition.WileyBlackwellPublication.



32

CH2 205OrganicChemistry (L-T-P-C:3-0-0-3)

Unit1:ChemistryofHalogenatedHydrocarbonsAlkylhalides:Methods ofpreparation, nucleophilic substitution reactions– SN1, SN2andSNimechanisms with stereochemical aspects and effect of solvent etc.; nucleophilicsubstitutionvs.elimination.Aryl halides: Preparation, including preparation from diazonium salts. nucleophilicaromatics ubstitution;SNAr,Benzynemechanism.Relative reactivity of alkyl, allyl/benzyl, vinyl and aryl halides towards nucleophilicsubstitutionreactions.OrganometalliccompoundsofMgandLi – Useinsynthesisoforganiccompounds.Unit2:Alcohols,Phenols,EthersandEpoxidesAlcohols:preparation,propertiesandrelativereactivityof1°,2°,3°alcohols,Bouvaelt-BlancReduction;Preparationandpropertiesofglycols:Oxidationbyperiodicacidandleadtetraacetate,Pinacol-Pinacolonerearrangement;Phenols: Preparation and properties; Acidity and factors effecting it, Ring substitutionreactions, Reimer–Tiemann and Kolbe’s–Schmidt Reactions, Fries and Claisenrearrangementswithmechanism;Ethers and Epoxides: Preparation and reactions with acids. Reactions of epoxides withalcohols,ammoniaderivativesandLiAlH4

ReferenceBooks:1. OrganicChemistrybyJ.Clayden.2. OrganicChemistrybyR.N.BoydandR.T.Morrison3. TextbookofOrganicChemistryby(2019)ArunBahlandBSBahl,Schandseries.4. OrganicChemistrybyPYBruice(Pearson,2019)



33

CH2206CommunicationSkills II (L-T-P-C:1-1-0-0)

Unit1:BusinessCommunicationTypesofLettersandformat,complaintlettersandlettersofregretandadjustment,E-mail-DosandDon’tsUnit2:ResumeandjobapplicationUnit3:SpeakingSkillsPresentationsbasedoncaselets,GroupDiscussion&PersonalInterviewUnit4:ReportWriting

Reference Books:1. BusinessCommunication:AshaKaul2. BusinessCorrespondenceandReportWriting– R.C.Sharma,KrishnaMohan(Tata

McGraw)

CH2207Seminar (L-T-P-C:1-0-0-1)



34

CH2208Lab 10InorganicQualitativeandGravimetricAnalysis (L-T-P-C:0-0-6-3)

Inorganica. InorganicQualitativeanalysis(fourmixtures tobeanalysed includingphosphateand

Borate)Gravimetrica. Determinationofwaterofcrystallisationofgivensalt.BaCl2 2H2O,Mg.SO4 7H2Ob. DeterminationofPercentagePurityofgivensalt(Na2CO3,NaHCO3)SolventExtractiona. ToseparateamixtureofNi2+&Fe2+ bycomplexationwithDMGandextractingtheNi2+-

DMGcomplexinchloroform,anddetermineitsconcentrationbyspectrophotometryIonexchangea. Determination of exchange capacity of cation exchange resins and anion exchange

resins.b. Separationofmetalionsfromtheirbinarymixture.c. Separationofaminoacidsfromorganicacidsbyionexchangechromatography.

CH2209Lab11PhysicalChemistry (L-T-P-C:0-0-6-3)

1. PreparationofbuffersolutionsofdifferentpHa. Sodiumacetate-aceticacidb.Ammoniumchloride-ammoniumhydroxide

2. pHmetrictitrationof(i)strongacidvs.strongbase,(ii)weakacidvs.strongbase.3. Determinationofdissociationconstantofaweakacid.4. Determination of heat capacity of the calorimeter and enthalpy of neutralization of

hydrochloricacidwithsodiumhydroxide5. Determinationofenthalpyofhydrationofcoppersulphate.6. Studyofthesolubilityofbenzoicacidinwateranddeterminationof∆H.7. Performthefollowingconductometrictitrations:a. Strongacidvs.strongbaseb. Weakacidvs.strongbasec. Mixtureofstrongacidandweakacidvs.strongbased. Strongacidvs.weakbase

8. Potentiometry: -Performthefollowingpotentiometrictitrations:a. Strongacidvs.strongbaseb. Weakacidvs.strongbasec. Dibasicacidvs.strongbased. Potassiumdichromatevs.Mohr'ssalt



35

CH2 210 Lab12LifeSciences (L-T-P-C:0-0-4-2)

1. Bloodsmearpreparation2. RBCandWBCenumeration3. Totalcountanddifferentialcount4. BloodgroupingandRhtyping5. Separationoflymphocytesfromblood6. Widaltest7. Immunoelectrophoresisandserumelectrophoresis8. DemonstrationofdetectionofHbsAgbyELISA9. Singleimmune-diffusiontechniqueseg.Radialimmune-diffusion10. Blood-glucoseestimation

CH2 211 Lab13Physics (L-T-P-C:0-0-4-2)

1. Filtercircuit2. Kater’spendulum3. Flywheel4. Doublerefraction5. Polarimeter6. Smallthicknessbyopticallever7. Charging-dischargingofacapacitor(RCcircuit)8. Transistoramplifier– current,voltageandpowergains9. Figureofmeritofaballisticgalvanometer10. Highresistancebysubstitutionmethod



36

SEMESTER - V

CH3101OrganicReactionsofCarbonylCompounds,SulphurContainingCompounds(L-T-P-C:3-1-0-4)

Unit1:CarbonylCompoundsStructure, reactivity and preparation; Nucleophilic additions, Nucleophilic additioneliminationreactionswithammoniaderivativeswithmechanism;MechanismsofAldolandBenzoin condensation, Knoevenagel condensation, Claisan-Schmidt, Perkin, CannizzaroandWittigreaction,BeckmannandBenzil-Benzilicacidrearrangements,haloformreactionand Baeyer Villiger oxidation, α - substitution reactions, oxidations and reductions(Clemmensen,Wolff-Kishner, LiAlH4, NaBH4,MPV, PDC and PGC); Addition reactions ofunsaturated carbonyl compounds:Michael addition. Activemethylene compounds:Keto-enoltautomerism. Preparation and synthetic applications of diethyl malonate and ethylacetoacetate.Unit2:CarboxylicAcidsandtheirDerivativesPreparation,physicalpropertiesandreactionsofmonocarboxylicacids:Typicalreactionsofdicarboxylicacids,hydroxyacidsandunsaturatedacids:succinic/phthalic, lactic,malic,tartaric, citric, maleic and fumaric acids; Preparation and reactions of acid chlorides,anhydrides,estersandamides;Comparativestudyofnucleophilicsustitutionatacylgroup-Mechanism of acidic and alkaline hydrolysis of esters, Claisen condensation, DieckmannandReformatskyreactions,Hofmann-bromamidedegradationandCurtiusrearrangement.Unit3:SulphurContainingCompoundsPreparationandreactionsofthiols,thioethersandsulphonicacidsUnit4:NitrogenContainingFunctionalGroupsPreparation and important reactions of nitro and compounds, nitriles and isonitriles.Amines:Effectofsubstituentandsolventonbasicity;Preparationandproperties:Gabrielphthalimide synthesis, Carbylamine reaction, Mannich reaction, Hoffmann’s exhaustivemethylation,Hofmann-eliminationreaction;Distinctionbetween1°,2°and3°amineswithHinsberg reagent and nitrous acid. Diazonium Salts: Preparation and their syntheticapplications.Unit5:PolynuclearHydrocarbonsReactions of naphthalene phenanthrene and anthracene Structure, Preparation andstructure elucidation and important derivatives of naphthalene and anthracene;Polynuclearhydrocarbons.

Reference Books:a. Aguidebooktoreactionmechanismsinorganicchemistry– PeterSykesb. Mechanismandstructureinorganicchemistry- S.M.Mukherji&S.P.Singhc. OrganicChemistry- L.G.WadeJrd. AdvancedOrganicChemistry,PartA:StructureandMechanisms- FrancisA.Careyand

RichardJ.Sundberg5. Advanced Organic Chemistry: Part B: Reaction and Synthesis - Francis A. Carey and

RichardJ.Sundberg



37

6. OrganicChemistry- Greeves,Warren,andWothers Clayden7. OrganicChemistry- PaulaY.Bruice



38

CH3 102ChemistryofdandfBlockElements (L-T-P-C:3-1-0-4)

Unit1:CoordinationChemistryWerner’s theory, valence bond theory (inner and outer orbital complexes),electroneutralityprincipleandbackbonding.Crystalfieldtheory,measurementof10Dq(o),CFSEinweakandstrongfields,pairingenergies,factorsaffectingthemagnitudeof10Dq(o, t).Octahedralvs. tetrahedralcoordination, tetragonaldistortions fromoctahedralgeometryJahn-Tellertheorem,squareplanargeometry.QualitativeaspectofLigandfieldandMOTheory.IUPACnomenclatureof coordinationcompounds, isomerism incoordination compounds.Stereochemistry of complexes with 4 and 6 coordination numbers. Chelate effect,polynuclearcomplexes,Labileandinertcomplexes.Unit2:TransitionElementsGeneral group trendswith special reference to electronic configuration, colour, variablevalency,magnetic andcatalyticproperties, ability to formcomplexes. Stabilityofvariousoxidation states and e.m.f. (Latimer & Bsworth diagrams).Difference between the first,secondandthirdtransitionseries.ChemistryofTi,V,CrMn,FeandCoinvariousoxidationstates(excludingtheirmetallurgy)Unit2:LanthanoidsandactinoidsElectronic configuration, oxidation states, colour, spectral and magnetic properties,lanthanidecontraction,separationoflanthanides(ion-exchangemethodonly).

Reference Books:1. PrinciplesofInorganicChemistrybyPuri,SharmaandKaliaVishalPublications1996.2. ConciseInorganicChemistrybyJ.D.Lee3rdEd.3. BasicInorganicChemistrybyF.A. Cotton,G. WilkinsonandPaul. L. Gaus.4. ChemistryoftheelementsbyN.N. GreenwoodandA.EarnshawPergamonPress1989.5. InorganicChemistrybyShriverandAtkins3rdednOxfordPress1999.6. Inorganic Chemistry Principles of structure and reactivity by James E. Huhey, E.A.

KeiterandR.L.Keiter4th Ed.7. TextbookofinorganicchemistrybyRGopalan.8. SelectedtopicsinInorganicChemistrybyMadan,MalikandTuli.



39

CH3 103ElectrochemistryandSurfaceChemistry(L-T-P-C:3-1-0-4)

Unit1:Electrochemistry IArrhenius theory of electrolytic dissociation. Conductivity, equivalent and molarconductivity and their variation with dilution for weak and strong electrolytes. Molarconductivityat infinite dilution. Kohlrauschlawofindependentmigrationofions. Debye-Hückel-Onsagerequation,Wieneffect,Debye-Falkenhageneffect,Walden’srules.Ionic velocities, mobilities and their determinations, transference numbers and theirrelation to ionic mobilities, determination of transference numbers using Hittorf andMoving Boundary methods. Applications of conductance measurement: (i) degree ofdissociationofweakelectrolytes, (ii) ionicproductofwater (iii) solubility andsolubilityproduct of sparingly soluble salts, (iv) conductometric titrations, and (v) hydrolysisconstantsofsalts.Unit2:Electrochemistry IIQuantitativeaspectsofFaraday’slawsofelectrolysis,rulesofoxidation/reductionofionsbasedonhalf-cellpotentials,applicationsofelectrolysisinmetallurgyandindustry.Chemicalcells,reversibleandirreversiblecellswithexamples. Electromotiveforceofacelland its measurement, Nernst equation; Standard electrode (reduction) potential and itsapplication to different kinds of half-cells. Application of EMF measurements indetermining (i) free energy, enthalpy and entropy of a cell reaction, (ii) equilibriumconstants, and (iii) pH values, using hydrogen, quinone-hydroquinone, glass electrodes.Concentration cells with and without transference, liquid junction potential. Fuel Cell:Principle,typesandtheirfunctioning.Unit3:SurfaceChemistryReactiononSurfaces-Physisorptionandchemisorption,adsorptionisotherms,derivationsofLangmuiradsorptionisotherm,mechanismofsurfacereactions

Reference Books:1. AnIntroductiontoElectrochemistry- SamuelGlasstone(10thEd)2. ElectrochemistrybyM.S.Yadav.3. Textbookofphysicalchemistry-Puri&Sharma.4. Textbookofadvancedphysicalchemistry– Gurudeepraj.



40

CH3 104MolecularSpectroscopyandStructureElucidation(L-T-P-C:3-1-0-4)

Unit1:MolecularSpectroscopyInteractionofelectromagneticradiationwithmoleculesandvarioustypesofspectra;Born-Oppenheimerapproximation.GeneralprinciplesIntroductiontoabsorptionandemissionspectroscopy.Rotationspectroscopy:Selectionrules,intensitiesofspectrallines,determinationofbondlengthsofdiatomicandlineartriatomicmolecules,isotopicsubstitution.Vibrational spectroscopy: Classical equation of vibration, computation of force constant,amplitudeofdiatomicmolecularvibrations, anharmonicity,Morsepotential, dissociationenergies, fundamental frequencies, overtones, hot bands, degrees of freedom forpolyatomicmolecules,modesofvibration,conceptofgroupfrequencies.Vibration-rotationspectroscopy:diatomicvibratingrotator,P,Q,Rbranches.Raman spectroscopy:Qualitative treatment ofRotational Raman effect; Effect of nuclearspin, Vibrational Raman spectra, Stokes and anti-Stokes lines; their intensity difference,ruleofmutualexclusion.Electronicspectroscopy:Franck-Condonprinciple,electronictransitions,singletandtripletstates, fluorescenceandphosphorescence,dissociationandpredissociation,calculationofelectronictransitionsofpolyenesusingfreeelectronmodel.Nuclear Magnetic Resonance (NMR) spectroscopy: Principles of NMR spectroscopy,Larmor precession, chemical shift and low resolution spectra, different scales, spin-spincouplingandhighresolutionspectra,interpretationofPMRspectraoforganicmolecules.Electron Spin Resonance (ESR) spectroscopy: Its principle, hyperfine structure, ESR ofsimpleradicals.Unit2:OrganicSpectroscopyUVSpectroscopy: Types of electronic transitions, λmax, Chromophores andAuxochromes,BathochromicandHypsochromicshifts,Intensityofabsorption;ApplicationofWoodwardRules for calculation of λmax for the following systems: α,β unsaturated aldehydes,ketones, carboxylic acids and esters; Conjugated dienes: alicyclic, homoannular andheteroannular;Extendedconjugatedsystems(aldehydes,ketonesanddienes);distinctionbetweencisandtransisomers.IRSpectroscopy: Fundamental andnon-fundamentalmolecularvibrations; IRabsorptionpositions of O, N and S containing functional groups; Effect of H-bonding, conjugation,resonance and ring size on IR absorptions; Fingerprint region and its significance;applicationinfunctionalgroupanalysis.NMR Spectroscopy: Basic principles of Proton Magnetic Resonance, chemical shift andfactors influencing it; Spin – Spin coupling and coupling constant; Anisotropic effects inalkene, alkyne, aldehydes and aromatics, Interpretation of NMR spectra of simplecompounds.ApplicationsofIR,UVandNMRforidentificationofsimpleorganicmolecules.

Reference Books:1. InstrumentalmethodsofAnalysis- Willard,Dean&Settle.2. PrinciplesofInstrumentalAnalysis- Skoog,HollerandWieman.



41

3. Introductiontophotoelectronspectroscopy- P.K.Ghosh.4. ApplicationsofMössbauerSpectroscopy- GreenWood.5. Structuralinorganicchemistry-Mössbauerspectroscopy– Bhide.6. Spectroscopicidentificationoforganiccompounds- Silverstein,BasselerandMorril.7. Applicationofabsorptionspectroscopy- JohnR.Dyer.8. NMRinchemistry-Amultinuclearintroduction- WillamKemp.9. OrganicSpectroscopy- WilliamKemp.10. SpectroscopicmethodsinOrganicchemistry- DHWilliamsandIFleming.11. ModernNMRtechniquesfor chemistryresearch- AndrewBDerome.12. Introductiontoorganicspectroscopy– Pavia.13. Applications ofMössbauer spectroscopy -N.N.GreenwoodandT.C. Gibb, Chapman&

Hall.14. PrinciplesofMössbauerspectroscopy-T.C. Gibb,Chapman&Hall.15. Physicalmethodsforchemists- R.S.Drago,2ndEd.16. Spectroscopyoforganiccompounds- P.S.Kalsi.



42

CH3105Lab14 OrganicChemistry (L-T-P-C:0-0-6-3)

1. Twoorganiccomponentmixtureseparation(Mixtureseparationoforganicacid,base,phenol,neutralcomponentsbychemicalmethod

2. Extractionofcaffeinefromtealeaves.3. Preparationofureaformaldehyde.4. AnalysisofCarbohydrate:aldosesandketoses,reducingandnon-reducingsugars.5. Qualitative analysis of unknown organic compounds containing monofunctional

groups(carbohydrates,arylhalides,aromatichydrocarbons,nitrocompounds,aminesand amides) and simple bifunctional groups, for e.g. salicylic acid, cinnamic acid,nitrophenolsetc.

6. Preparationofmethylorange.

CH3106Lab15 PhysicalandInorganic (L-T-P-C:0-0-6-3)

PhysicalStudythekineticsofthefollowingreactions.1. Initialratemethod:Iodide-persulphatereaction2. Integratedratemethod:a.Acidhydrolysisofmethylacetatewithhydrochloricacid.b. Saponificationofethylacetate.

3. Compare the strengths of HCl and H2SO4 by studying kinetics of hydrolysis ofmethylacetate.

4. DeterminetherateconstantfortheinversionofsucroseusingapolarimeterAdsorptionVerify the FreundlichandLangmuir isotherms foradsorptionof acetic acidon activatedcharcoalInorganic1. Measurementof10Dqbyspectrophotometricmethod2. Verificationofspectrochemicalseries.3. Controlled synthesis of two copper oxalate hydrate complexes: kinetic vs

thermodynamicfactors.4. PreparationofacetylacetanatocomplexesofCu2+/Fe3+.Findtheλmax ofthecomplex.5. Synthesis of ammine complexes of Ni(II) and its ligand exchange reactions (e.g.

bidentateligandslikeacetylacetone,DMG,glycine)bysubstitutionmethod



43

CH3107Lab16 AnalyticalTools (L-T-P-C:0-0-6-3)

UV/Visiblespectroscopy1. Studythe200-500nmabsorbancespectraofKMnO4 andK2Cr2O7 (in0.1MH2SO4)and

determine the λ max values. Calculate the energies of the two transitions in differentunits(Jmolecule-1,kJmol-1,cm-1,eV).

2. StudythepH-dependenceoftheUV-Visspectrum(200-500nm)ofK2Cr2O7.3. Recordthe200-350nmUVspectraofthegivencompounds(acetone,acetaldehyde,2-

propanol,aceticacid)inwater.CommentontheeffectofstructureontheUVspectraoforganiccompounds.

4. IdentificationofsimpleorganiccompoundsbyIRspectroscopyandNMRspectroscopy(Spectratobeprovided).

Colorimeter1. VerifyLambert-Beer’slawanddeterminetheconcentrationofCuSO4/KMnO4/K2Cr2O7

inasolutionofunknownconcentration2. DeterminetheconcentrationsofKMnO4 andK2Cr2O7 inamixture.3. Studythekineticsofiodinationofpropanoneinacidicmedium.4. Determinetheamountofironpresentinasampleusing1,10-phenathroline.5. Determinethedissociationconstantofanindicator(phenolphthalein).6. Study the kinetics of interaction of crystal violet/phenolphthalein with

sodiumhydroxide.7. Analysisofthegivenvibration-rotationspectrumofHCl(g)



44

SEMESTER- VI

CH3 201Hetreocycles,Alkaloids,Terpenes,DrugsandPharmaceuticals(L-T-P-C:3-1-0-4)

Unit1:HeterocyclicCompoundsClassification and nomenclature, Structure, aromaticity in 5-numbered and 6-memberedrings containing one heteroatom; Synthesis, reactions and mechanism of substitutionreactions of: Furan, Pyrrole (Paal-Knorr synthesis, Knorr pyrrole synthesis, Hantzschsynthesis),Thiophene,Pyridine(Hantzschsynthesis),Pyrimidine,Structureelucidationofindole, Fischer indole synthesis and Madelung synthesis), Structure elucidation ofquinoline and isoquinoline, Skraup synthesis, Friedlander’s synthesis, Knorr quinolinesynthesis, Doebner-Miller synthesis, Bischler-Napieralski reaction, Pictet-Spenglerreaction,Pomeranz-FritschreactionDerivativesoffuran:Furfuralandfuroicacid.Unit2:AlkaloidsNaturaloccurrence,Generalstructuralfeatures,IsolationandtheirphysiologicalactionHoffmann’s exhaustive methylation, Emde’s modification, Structure elucidation andsynthesis of Hygrine and Nicotine. Medicinal importance of Nicotine, Hygrine, Quinine,Morphine,Cocaine,andReserpineUnit3: TerpenesOccurrence, classification, isoprene rule; Elucidation of stucture and synthesis of Citral,Neralandα-terpineol.Unit4:Drugs&PharmaceuticalsDrugdiscovery,designanddevelopment;BasicRetrosyntheticapproach.Synthesisoftherepresentative drugs of the following classes: analgesics agents, antipyretic agents, anti-inflammatory agents (Aspirin, paracetamol, lbuprofen); antibiotics (Chloramphenicol);antibacterial and antifungal agents (Sulphonamides; Sulphanethoxazol, Sulphacetamide,Trimethoprim); antiviral agents (Acyclovir), Central Nervous System agents(Phenobarbital,Diazepam),Cardiovascular(Glyceryltrinitrate),antilaprosy(Dapsone),HIV-AIDSrelateddrugs(AZT- Zidovudine).

Reference Books:1. OrganicChemistry– Volume-I&II– I.L.Finar2. Heterocycles– R.K.Bansal3. Anintroductiontochemistryofheterocycliccompounds– R.M.Acheson4. Anintroductiontochemistryofterpenoidsandsteroids– WilliamTempleton5. Thealkaloids– KennethWalterBentley



45

CH3 202OrganometalicandCatalysis (L-T-P-C:3-1-0-4)

Unit1:IntroductiontoOrganometallicCompounds &PropertiesDefinitionandclassificationoforganometalliccompoundsonthebasisofbondtype.Conceptofhapticityoforganicligands.Metal carbonyls: 18 electron rule, electron count of mononuclear, polynuclear andsubstituted metal carbonyls of 3d series. General methods of preparation (directcombination,reductivecarbonylation,thermalandphotochemicaldecomposition)ofmonoandbinuclearcarbonylsof3dseries. StructuresofmononuclearandbinuclearcarbonylsofCr, Mn, Fe, Co and Ni using VBT.π-acceptor behaviour of CO (MO diagram of CO to bediscussed),synergiceffectanduseofIRdatatoexplainextentofbackbonding.Zeise’s salt: Preparation and structure, evidences of synergic effect and comparison ofsynergiceffectwiththatincarbonyls.Metal Alkyls: Important structural features of methyl lithium (tetramer) and trialkylaluminium (dimer), concept of multicentre bonding in these compounds. Role oftriethylaluminiuminpolymerisationofethene(Ziegler– NattaCatalyst).SpeciespresentinethersolutionofGrignardreagentandtheirstructures,Schlenkequilibrium.Ferrocene: Preparation and reactions (acetylation, alkylation, metallation, MannichCondensation). Structureandaromaticity. Comparisonof aromaticityand reactivitywiththatofbenzene.Unit2:ReactionKineticsandMechanismIntroduction to inorganic reaction mechanisms. Substitution reactions in square planarcomplexes,Trans- effect,theoriesoftranseffect,Mechanismofnucleophilicsubstitutioninsquare planar complexes, Thermodynamic and Kinetic stability, Kinetics of octahedralsubstitution, Ligand field effects and reaction rates, Mechanism of substitution inoctahedralcomplexes.Unit3:CatalysisbyOrganometallicCompoundsStudyofthefollowingindustrialprocessesandtheirmechanism:1. Alkenehydrogenation(WilkinsonsCatalyst)2. Hydroformylation(Cosalts)3. WackerProcess4. Syntheticgasoline(FischerTropschreaction)5. SynthesisgasbymetalcarbonylcomplexesUnit4:OrganometallicandOrganicSynthesisReactionsofMg,Li,Cu,Zn,Pd,Co,Cr

Reference Books:1. OrganometallicChemistry,R.C.MehrotraandA.Singh,Newageinternational.2. MetalorganicChemistry,A.J.Pearson,Wiley.3. OrganometallicchemistrybyRCMalhothra



46

CH3 203QuantumChemistry (L-T-P-C:3-1-0-4)

Unit1:QuantumChemistryPostulates of quantummechanics, quantummechanical operators, Schrödinger equationand its application to free particle and “particle-in-a-box” (rigorous treatment),quantization of energy levels, zero-point energy and Heisenberg Uncertainty principle;wavefunctions,probabilitydistribution functions,nodalproperties,Extension to twoandthreedimensionalboxes,separationofvariables,degeneracy.Qualitativetreatmentofsimpleharmonicoscillatormodelofvibrationalmotion:SettingupofSchrödingerequationanddiscussionofsolutionandwavefunctions.Vibrationalenergyofdiatomicmoleculesandzero-pointenergy.Angular momentum: Commutation rules, quantization of square of total angularmomentumandz-component.Rigidrotatormodelofrotationofdiatomicmolecule.Schrödingerequation,transformationto spherical polar coordinates.Separation of variables.Sphericalharmonics.Discussion ofsolution.Qualitativetreatmentofhydrogenatomandhydrogen-likeions:settingupofSchrödingerequation in spherical polar coordinates, radial part, quantization of energy (only finalenergyexpression).Averageandmostprobabledistancesofelectronfromnucleus.Setting up of Schrödinger equation for many-electron atoms (He, Li). Needforapproximationmethods.Statement of variation theorem and application to simplesystems(particle-in-a-box,harmonicoscillator,hydrogenatom).Unit2:Chemicalbonding:Covalentbonding,valencebondandmolecularorbitalapproaches,LCAO-MOtreatmentofH2+.Bondingandantibondingorbitals. Qualitativeextension toH2.ComparisonofLCAO-MOandVBtreatmentsofH2 (onlywavefunctions,detailedsolutionnotrequired)andtheirlimitations. Refinements of the two approaches (Configuration Interaction forMO, ionicterms in VB).Qualitative description of LCAO-MO treatment of homonuclear andheteronucleardiatomicmolecules(HF,LiH).Localisedandnon-localisedmolecularorbitalstreatmentoftriatomic(BeH2,H2O)molecules.QualitativeMOtheoryanditsapplicationtoAH2 typemolecules.

Reference Books:1. QuantumChemistry,IraN.Levine,PrenticeHall.2. IntroductiontoQuantumChemistry,A.K.Chandra,TataMcGrawHill.3. ConciseInorganicChemistrybyJ.D.Lee3rdedn.4. BasicInorganicChemistrybyF.A.Cotton,G.WilkinsonandPaul.L.Gaus3rdednWiley

Publishers2001.Chem5. AnalyticalchemistrybyG.L.DavidKrupadanam,D.VijayaPrasad,K.VaraprasadaRao,

K.L.N.ReddyandC.Sudhakar.



47

CH3 204BioorganicandBioinorganicChemistry(L-T-P-C:3-1-0-4)

Unit1:AminoAcids,PeptidesandProteinsAminoacids,Peptidesandtheirclassification. α-AminoAcids- Synthesis,ionicpropertiesand reactions. Zwitterions, pKa values, isoelectric point and electrophoresis; Study ofpeptides: determination of their primary structures-end group analysis, methods ofpeptidesynthesis.SynthesisofpeptidesusingN-protecting,C-protectingandC-activatinggroups-Solid-phasesynthesisUnit2:CarbohydratesOccurrence,classificationand theirbiological importance. Monosaccharides:Constitutionand absolute configuration of glucose and fructose, epimers and anomers,mutarotation,determinationofringsizeofglucoseandfructose,Haworthprojectionsandconformationalstructures; Interconversions of aldoses and ketoses; Killiani-Fischer synthesis and Ruffdegradation; Disaccharides – Structure elucidation of maltose, lactose and sucrose.Polysaccharides– Elementarytreatmentofstarch,celluloseandglycogenUnit3:LipidsIntroductiontooilsandfats;commonfattyacidspresentinoilsandfats,Hydrogenetionoffatsandoils,Saponificationvalue,acidvalue,iodinenumber.Reversionandrancidity.Unit4:NucleicAcidsComponents of nucleic acids, Nucleosides and nucleotides; Structure, synthesis andreactionsof:Adenine,Guanine,Cytosine,UracilandThymine;Structureofpolynucleotides.Unit5:Bio-InorganicChemistryA brief introduction to bio-inorganic chemistry. Role ofmetal ions present in biologicalsystemswithspecialreferencetoNa+,K+ andMg2+ ions:Na/Kpump;RoleofMg2+ ionsinenergyproductionandchlorophyll. RoleofCa2+ inbloodclotting, stabilizationofproteinstructures andstructuralrole(bones).Bio-InorgnaicChemistryofIron,HaemProteins,VitaminB-12-StructureandApplications

Reference Books:1. BioinorganicChemistry,L.Bertini,H.B.Gray,S.J.Lippardand S.J.Valentine,VivaLow-

PricedStudentedition.2. PrinciplesofBioinorganicChemistry,S.J.LippardandBerg.8.BioinorganicChemistry,

K.HussainReddy,NewAgeinternationalPublishers3. BioorganicchemistrybyH.Dugas.4. BioinorganicandBioorganic chemistrybyP.S.Kalsi.

CH3205ChemistryProject/IndustrialVisit/ComprehensiveViva (6sems) (L-T-P-C:0-0-12-6)

IUCCIDInnovativeProject(Concept,Conceive,ImplementandDeliver) (L-T-P-C:0-0-0-2)

indrashil university · hetreocycles, alkaloids, terpenes, drugs and pharmaceuticals 3-1-0 4 ......

Documents