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REPORTOFTHEIndo-Usworksh

oponLow-cost

diagnosticandTher

apeuticmed

icalTechno

logies

30 June 2009

National Institute of Biomedical Imaging and

Bioengineering (NIBIB)

United States

Department of Biotechnology (DBT)

India

Report of the Workshop in Hyderabad, India

November 2009

Workshop Summary

Recommendations of Workshop Participants

Next Steps

Website

Travel supplements/pilot studies/collaborations

DBT-NIBIB Joint Funding Initiatives

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Table of ContentsOverview........................................................................................................................................................ 3

Purpose of the Workshop ............................................................................................................................ 5

Goals of the Workshop ................................................................................................................................. 5

Outcomes and Priority Recommendations of the Workshop ................................................................... 6

Other recommendations and highlights of workshop presentations........................................................ 9

Participants ..................................................................................................................................................11

Workshop Sponsors.....................................................................................................................................28

Indo-U.S. Science and Technology Forum ............................................................................................ 28

National Institute of Biomedical Imaging and Bioengineering ......... ........... .......... .......... ........... ........... 29

Department of Biotechnology, Ministry of Science and Technology .................................................... 30

Acknowledgements ......................................................................................................................................31

Authors .........................................................................................................................................................32

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Report of the Indo-US Workshop on Low-Cost Diagnosticand Therapeutic Medical Technologies:

Overview

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) of the National Institutes ofHealth in the US and the Department of Biotechnology (DBT) of the Ministry of Science andTechnology in India issued a joint statement on 5 October 2007 to cooperate on the development oflow-cost diagnostic and therapeutic medical technologies. This workshop brought together interestedparties from each country to identify joint opportunities for productive collaborations.

Scientists, engineers and clinicians from the U.S. and India participated in the workshop on low-costdiagnostic and therapeutic technologies, 18-20 November 2008 in Hyderabad, India. Participantspresented talks, recommended priorities for medical technologies needed in low-resource settings, andidentified six priority areas. Over the course of the two-day meeting, attendees discussed clinical needsand technological opportunities and participated in panel discussions on ideas and recommendations.Six priority areas opportunity resulted from these discussions including the top priorities of:

1. Low-cost glucose monitoring for diabetes care

2. Low-cost, platform technologies for multiple diagnostic tests:

a. A multiplex, lab-on-a-chip technology for STD and other infectionsb. Point-of-care diagnostics for infant screeningc. A pre-screening test for blood bank safety.d. Early detection of cardiovascular disease.e. Point-of-care tests and reagents for cancer screening

As a result of the workshop, NIBIB and DBT plan to collaborate and jointly fund initiatives in therecommended priority areas. The priorities recommended above were distilled from a long list ofideas and recommendations that had been discussed in workshop presentations and panel discussionsover the previous two days (See additionalrecommendationsbelow.). Workshop sessions on low-costtechnologies spanned the chronic disease spectrum with focus on:

1. Cancer,

2. Cardiovascular disease,

3. Diabetes,

4. Gastrointestinal tract disorders and liver disease, and

5. Maternal, newborn and infant health.

Indian manufacturing opportunities and regulatory issues were also presented. The workshop endedwith a review of recommendations and a discussion of the next steps.

The workshop was structured to explore shared needs and opportunities for improving theeffectiveness of medical technologies to reduce health disparities for chronic medical conditions. Onefocus was to identify appropriate diagnostic and therapeutic technologies. The appropriate medicaltechnologies are those that that are useable, cost effective, sustainable, and effective in meeting asignificant clinical need for a given healthcare setting. The medical technologies discussed at the

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workshop were those that could address global health disparities and significantly impact underservedpopulations within both the US and India. Within this context the goals were:

to identify areas of opportunity for improving health care delivery for chronic diseases;

to identify potential appropriate technologies that can contribute to healthcare in low-resourcesettings;

to identify specific technology challenges in target appropriate technologies;

to identify and lay foundations for partnerships between researchers in the US and India; and

to plan the next steps in implementing collaborative programs and joint activities that makeeffective use of the strengths of both countries.

To accomplish these goals, the meeting had three major components:

Plenary talks on emerging technologies and emerging technological resources;

working sessions organized around specific disease conditions and relevant technologies; and

a session to develop recommendations and next steps.

The first 2 components of the workshop formed the foundation for the concluding session whichfocused on next steps in advancing a US-India partnership:

What are some of the leading candidates for a joint activity?

Are there low hanging fruits that should be worked on at once?

Are there long-term strategic activities that will significantly advance health care in low-resource settings?

Figure 1. Participants from the U.S. and India at the workshop on low-costdiagnostic and therapeutic technologies, 18-20 Nov 2008 in Hyderabad, India.

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Purpose of the Workshop

Diagnostic and therapeutic technologies are critical for quality health care, yet there remains a widedisparity between those who have access to modern medical technologies and those who do not. Thesehealth disparities are due, in part, to the high cost of medical technologies used to diagnose and treatdisease. Despite the enormous intellectual resources and engineering capacity of both India and theUnited States and state-of-the-art resources at major medical and research centers, there remains alarge proportion of people who do not have access to modern medical technologies1. Jointdevelopment of affordable, innovative devices is needed, with particular emphasis on early detectionand the efficient treatment of disease and injury.

The Indo-US workshop on Low-Cost Diagnostic and Therapeutic Medical Technologies brought

together U.S. and Indian scientists, engineers, and clinicians to discuss collaboration on thedevelopment of low-cost diagnostic and therapeutic medical technologies. India has enormoushuman resources in engineering, manufacturing and biomedical science. One purpose of thisworkshop was to harness the intellectual capacity of Indian engineers and scientists, and focus theirefforts to solve the engineering problems associated with developing low-cost medical devices.Complimentary expertise and technologies are found in the United States. Thus, U.S. scientists andengineers can work with their counterparts in India to develop nascent technologies, with the goal ofmaking low-cost medical technologies that could become more widely available in the U.S. and India.

Outcomes of the WorkshopThe workshop was structured to:

1. Develop an outline for joint Indo-U.S. (DBT-NIH) initiatives to foster collaboration betweenUS and Indian scientists on low-cost, diagnostic and therapeutic technologies.

2. Identify low-cost diagnostic and therapeutic medical technology needs/opportunities.

3. Identify clinical priorities that can be addressed by new, low-cost technologies.

Workshop speakers gave overviews of clinical needs and technological opportunities. Speakersand panel discussions produced key recommendations regarding clinical needs and priorities in

1Newsweek International, October 30, 2006

India U.S.Needs and

Opportunities

Figure 2. India and the U.S. both have enormous intellectual resources andengineering capacities that can address common medical needs. The purposeof the Indo-US workshop was to explore opportunities for collaboration toaddress overlapping healthcare needs in low-resource settings.

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low-resource settings as well as opportunities for the development of low-cost diagnostic andtherapeutic devices. Potential joint funding initiatives between DBT and NIBIB were discussed inthe recommended priority areas, including low-cost glucose monitors and platform technologiesfor multiple diagnostic tests. The recommendations from the workshop participants are containedin the report below.

Outcomes and Priority Recommendations of the Workshop

Prioritized Recommendations

Workshop participants recommended priorities for medical technologies needed in low-resourcesettings. There were six priority areas identified: 1) Glucose monitoring 2) low-cost, platformtechnologies for diagnostic tests 3) Imaging biomarker development 4) Low-cost, digital x-rayimaging 5) E-health technologies and 6) Low-cost, surgical technologies. Among these six topicsdescribed below, the first two were considered very high-priority areas and were discussed at somelength at the conclusion of the workshop.

1. Glucose monitoring

Low-cost glucose monitors for the management of diabetes are needed, particularly in low-resource settings in India. Ideally, glucose monitors could be developed that work on acontinuous basis and use no consumables. In addition to glucose meters, and continuousglucose monitoring, additional technologies are required for diabetes management. Theseinclude point of care glycosalated haemoglobin (HbA1c) measurement and insulin pumps.Another long-term goal is the development of an artificial pancreas (a closed loop system).

Near-term, glucose meter strips are a high priority. The cost of glucose meter strips(consumables), driven by the US market, is prohibitive. The glucose meter strip industry is

currently US$5-10 billion. The barriers to manufacturing a low-cost strip or manufacturing inIndia need to be explored and a low cost strip developed, as well as open-standard readers andstrips.

Discussion during concluding session also shared the need to implement strategies to preventmetabolic syndrome and diabetes by introducing lifestyle changes (food, exercise).

2. Low-cost, platform technologies for multiple diagnostic tests.

The development of low-cost, high-impact diagnostic tests was identified as a high-priority.Development of diagnostics is long term and expensive. An estimate of the time and cost todevelop a diagnostic test is 5 years and US$20 million). 70% of the cost is for field validation,2production and marketing, which are not often funded by government agencies. Thus, morepublic funding is required for these downstream processes.

Examples and issues include:

Diagnostic intermediates/biomarker development (e.g. recombinant proteins,monoclonal antibodies) are required for low-cost screening kits;

2 Bernhard Weigl, Program for Appropriate Technology in Health (PATH), Seattle, Washington, USA.

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the development of non-invasive screening technologies (e.g. imaging, microfluidics,microchip blood tests to detect circulating tumor cells.);

decoupling sensors (small) from processors (bulky) by transmitting data through web;

openstandards for platforms and networking;

and diagnostic screening technologies simple enough to be operated by people withminimal education (10th grade).

There is a need to develop multiplexed, lab-on-chip technologies to bring multiplebiomarker tests on to a single, universal platform, instead of multiple diagnostic tests onmultiple different instruments. Lab-on-a-chip technologies could be used in remote clinicsand low-resource settings as well as secondary and primary hospitals. For example,multiplexed, lab-on-a-chip (or strip) technologies could be developed for the diagnosis ofsexually transmitted diseases (STDs), rainy season diseases, fevers and other infections. Inaddition, the creation of a program for newborn screening was recommended along with thedevelopment of lab-on-a-chip, microfluidic technologies for the detection ofhemoglobinopathies, hypothyroidism and other conditions in newborns. The diagnosis ordetection of newborn disorders would have to be linked with viable treatments. Furthermore,this population screening in low-resource and rural areas requires portable technology (e.g.,

lab in a back-pack). An investment in multiplex, point-of-care technologies that coulddiagnose multiple diseases could solve many problems.

There is a critical need to develop a multiplexed strip assay to test blood at Indian blood banks.Currently, blood is tested post-donation. There is a need to develop a pre-screening,multiplexed test before blood is donated.

Low-cost, multiplex diagnostic tests could also be developed for the early detection ofcardiovascular disease. New, portable tests for the prediction and diagnosis of heart diseaseare needed.

Team science is needed to develop new diagnostic technologies. For example, a urologist,

biomathematician, engineers, and infectious disease specialist came together to develop theurosensor, an electrochemical sensor to detect pathogens associated with urinary tractinfections (UTIs).

In summary, the development of low-cost, platform technologies for diagnostic tests wasidentified as a high-priority for:

a. A multiplex, lab-on-a-chip technology for STD and other infectionsb. Point-of-care diagnostics for infant screeningc. A pre-screening test for blood bank safety.d. Early detection of cardiovascular disease.e. Point-of-care tests and reagents for cancer screening

3. Imaging biomarker development

Imaging biomarker development is important for specificity in the detection and diagnosis ofdisease. An area emphasis is on the development of quantitative, low-cost early screening forpre-cancerous lesions. New biomarkers could be tested in high-risk populations and inpatients who have undergone treatment (to monitor recurrence).

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4. Low-cost, digital x-ray imagingDigital x-ray systems would obviate the need for film and related supplies, and enableteleradiology applications, including the transmission of digital x-ray images to centralfacilities for expert interpretation. Representatives from General Electric in Bangalore

described work on the development of a complete digital x-ray system for use in remotesettings. A low-cost, digital x-ray detector (e.g., liquid crystal, x-ray light valve) is alsobeing developed by Dr. John Rowlands for integrated radiography and teleradiologyapplications.

5. E-health technologies

Many chronic conditions such as congestive heart failure are not adequately monitored usingtraditional office visits and, as a result, patients frequently experience avoidable hospitaladmissions. A paradigm shift is occurring from hospital-based treatment to preventivescreening, monitoring and self-monitoring using e-health technologies at home, in thecommunity, or at remote locations. An open-source, home based monitoring system for

diagnosis and e-health was recommended.

E-health applications can also be used to build a database for patients and the community byrecording family history, hospital tests, etc. These types of databases can provide clinicalinsight, as well as information towards new medical product development for the community.The development of e-health databases requires regulations to prevent abuse of theinformation and maintain patient confidentiality. With appropriate regulations in place for e-health studies, there is also a need to expedite institutional review board (IRB) and otherapprovals by both governments, India and the U.S.

6. Low-cost, surgical technologies.

The high cost of surgical technologies drives up the cost of surgery. Particularly in India,there is a need for low-cost surgical technologies in multiple settings. Specifically, there is aneed for indigenously developed and manufactured, low-cost hemostats, surgifoam, gelfoam,implants, sutures, pre-loaded syringes, and fixative. In addition, Indian industries need tomanufacture routinely used cardiac surgery and monitoring devices (ECG, echocardiogrammachines, monitors, tubing, and other surgical equipment).

Next Steps, Pilot activities and Joint Research Programs

The workshop ended with a prioritization of recommendations (above) and a discussion of the next

steps. A first step will be the development of a website describing the collaboration and joint programbetween the Indian Department of Biotechnology and the U.S. National Institute of BiomedicalImaging and Bioengineering, NIH. It is anticipated that this website will be hosted in India, and a URLwill be provided at a later date. Initial content of the site will include:

Program from the workshop

Workshop presentations

Biography /interest information on participants and others interested scientists and engineers

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Additional features of the website may include discussion areas for select topics and a directory ofU.S. and Indian scientists and engineers interested in low-cost diagnostic and therapeutic devices.

Pilot activities and Joint Initiatives

NIBIB will identify current NIBIB grantees in the U.S. with interest or existing collaborations with

Indian scientists for review of potential supplements to fund travel for pilot activities or planning inIndia. Similarly, DBT will identify Indian scientists for potential travel grants or collaborative pilotprojects with U.S. scientists.

Staff from NIH and DBT are working together to identify grand challenges based on the discussion atthe workshop for consideration by senior staff as potential joint targeted initiatives of the two agencies,DBT and NIBIB. Staff from NIH and DBT will formulate a structure for a first joint research programbased on the priorities identified at the workshop.

Other recommendations and highlights of workshop presentations

Remarks by Dr M.K. Bhan, Secretary, Department of Biotechnology (DBT), India

- This Indo-US collaboration will benefit other low resource settings globally.

- DBT is providing generous new schemes to fund industrial innovation. They are looking for low

hanging fruit, but also funding high-risk futuristic initiatives.

- DBT plans to put together a directory of Indian scientists and technologists with expertise in

platform design and diagnostics development.

Session I: Cancer Screening

In addition to the cancer diagnosis and screening technologies prioritized above, the followingrecommendations were also made.

- New technologies need to be developed as collaboration between engineers, clinicians,

technologists and global health experts.

- Screening technologies in India need to be simple enough to be operated by people with minimal

education (10th grade).

- Quantitative tools for monitoring therapy and for pre-clinical models

Session II: Cardiovascular diseases

- There are currently no Indian manufacturers of vacutainers, or pre-loaded emergency drugs in

syringes; these are urgently needed.

- A few immediate needs for detection and monitoring of cardiovascular diseases were identified.

These are depot penicillin, Prothrombin kit, Troponin kit.

Session III: Endocrine Disorders

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Diagnostic and therapeutic technologies for endocrine disorders, and specifically diabetes, aredescribed among the six priority areas above.

Session IV: GI Tract diseases

- New technologies for imaging were described, including, capsule endoscope, Magnetic Resonance

Elastography (MRE), and microfluidic microscope on a chip

- Mid-infra-red (IR) spectroscopy should be explored for breath analysis as a non-invasive

technology.

Plenary: Translational Research

- Technologies developed in the West need to be re-engineered to suit local needs. For example,

technologies developed in India such as the flow cytometer (ReaMetrix), insulin pump (Amrita-

Biocon), can be made using readily available standard components.

- Involvement of non-government organizations (NGOs), government funding agencies and industry

is required for technology innovation, wellness management and healthcare delivery. One

example is the Saantwanam health action program in Kerala.

Session V: Maternal/Neonatal/Infant Health

Recommendations included:

- The need to focus on a single high-priority problem with significant outcome.

- Regular forum (or virtual meetings) are needed for low-cost diagnostics where industry,

academia and government (funding agencies) work together.

- Expansion of a national program to prevent hypothyroidism.

Session VI: Trauma and Injury

Recommendations:

- There is a critical need in India for training in trauma care

- Low cost manufacturing of mannequins for training paramedics and physicians

- Low cost prosthetic materials

- Low-cost CT for tertiary care hospital

- EMRS low end technologies open source GPS

- More leverage should be given to indigenous industry to assist in patent and regulatory issues

- Pre-hospital care requires:

o Protocols

o Trauma backpack

o Mobile CT scanner

o Telemedicine

- At hospital ER, ICU and Operation Room:

o Indigenously developed, low-cost hemostats, surgifoam, gelfoam, implants, sutures,

pre-loaded syringes, fixative

o Low-cost C-arm, ultrasound, and CT

- Rehabilitation

o Low-cost wheelchair (designed, but not manufactured)

o Low-cost prosthetics and materials for prosthetic

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- Need to take innovation to production line

o Airway clearing, CNS assessment

Participants

WORKSHOP PARTICIPANTS FROM INDIA

Lakshmaiah AAssistant Director, Social and Preventive MedicineNational Institute of NutritionJamai-Osmania Post, Tarnaka, Hyderabad500 007Tel: +91-40-27008921 Extn. 277 Fax: +91-40-27018904abulalaxman@yahoo.com

Rakesh Agarwal

Dept of GastroenterologySanjay Gandhi Postgraduate Institute of Medical SciencesRaebareli Road, Lucknow226 014Tel : +91-522-2668004/2668008rakesh@sgpgi.ac13

Balram BhargavaProfessor, Department of CardiologyCardiothoracic Sciences CentreExecutive Director, Stanford India Biodesign ProgrammeAll India Institute of Medical Sciences,

New Delhi - 110029, INDIA,Tel: +91-11-26588663 Fax: +91-11-26588641balrambhargava@yahoo.com

Shama BhatManaging DirectorBhat Biotech India (P) Ltd, No.11-A, 4th CrossVeerasandra Industrial Area, Electronics City, Bengaluru560 100bhatbiotech@vsnl.com

P Sarat Chandra

Dept. of NeurosurgeryAll India Institute of Medical SciencesAnsari Nagar,New Delhi110 029saratpchandra@aiims.ac.in

Suresh DevasahayamProfessor of BioengineeringChristian Medical CollegeVellore - 632 002

mailto:abulalaxman@yahoo.commailto:abulalaxman@yahoo.commailto:rakesh@sgpgi.ac13mailto:rakesh@sgpgi.ac13mailto:balrambhargava@yahoo.commailto:balrambhargava@yahoo.commailto:bhatbiotech@vsnl.commailto:bhatbiotech@vsnl.commailto:saratpchandra@aiims.ac.inmailto:saratpchandra@aiims.ac.inmailto:saratpchandra@aiims.ac.inmailto:bhatbiotech@vsnl.commailto:balrambhargava@yahoo.commailto:rakesh@sgpgi.ac13mailto:abulalaxman@yahoo.com

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Tel: +91-416-228 4298surdev@cmcvellore.ac.in

T S GanesanDept. of Medical Oncology

Amrita Institute of Medical Sciences & Research CentreAmrita Lane, Etamakkara Post, Kochi, Kerala - 682 026Tel: +91-484-2801234, 2804321 Fax:+91-484-2802020tsganesan@aims.amrita.edu

C C KarthaCardiologistSree Chitra Tirunal Institute of Medical Sciences & TechnologyThiruvananthapuram - 695 011, KeralaTel: +91-471-2524400, 2443085 12N Krishna Reddy

Managing DirectorCARE Hospitals, Road No.1, Banjara Hills, Hyderabad500 034.Tel: +91-40-30418888 Fax: +91-40-30418488

Navin KhannaInternational Centre for Genetic Engineering & Biotechnology,P O Box : 10504, Aruna Asaf Ali Marg,New Delhi110 067.Tel : +91-11-2674135/61 Fax: +91-11-26742316navin@icgeb.res.in

Anoop MisraDirectorDept. of Diabetes & Metabolic disordersFortis Hospital, New DelhiS K PandaProfessor of PathologyAll India Institute of Medical SciencesAnsari Nagar, New Delhi110 029skpanda@aiims.ac.in & subrat@gmail.com

Mahesh C MisraProfessor & Head,Head, Minimal Access Surgery Unit,Incharge, Breast Cancer Clinic,Department of Surgical Disciplines andChief, JPN Apex Trauma Center,All India Institute of Medical SciencesAnsari Nagar, New Delhi - 110 029Tel: +91-11-26594776, 26593206, +91-9811896246, 9868397701,+91-11-26589655, 26594531Fax: +91-11-26588663, 26588641mcmisra@gmail.com, misramahesh@hotmail.com

mailto:surdev@cmcvellore.ac.inmailto:surdev@cmcvellore.ac.inmailto:tsganesan@aims.amrita.edumailto:tsganesan@aims.amrita.edumailto:navin@icgeb.res.inmailto:navin@icgeb.res.inmailto:navin@icgeb.res.inmailto:tsganesan@aims.amrita.edumailto:surdev@cmcvellore.ac.in

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V MohanChairman & Chief DiabetologistDr Mohans Diabetes Specialities CentreWHO Collaborating Centre for Non Communicable

Diseases Prevention & ControlPresident & Chief of Diabetes Research, Madras Diabetics Research FoundationICMR Advanced Centre for Genomics of Diabetes6 B, Conran Smith Road, Gopalapuram, Chennai600 086Tel: +91-44-43968888drmohans@vsnl.net

Rakesh MullickProject LeaderGE John F Welch Tech Center Imaging Technology LabEPIP Phase-II, Hoodi Village, Whitefield Road, Bengaluru560 066

N G Badari NarayanManaging DirectorRelisys Medical Devices LtdPlot No.82, Road No.6, Arunodaya Nagar, Nagole, Hyderabad500 068Tel: +91-40-23493311 Fax:+91-40-24222206 Email :ngbadari@gmail.com15B V RavikumarManaging DirectorXcyton Diagnostics Ltd449, 10th Cross, 4th Phase, Peenya Industrial Area, Bengaluru560 058Tel:+91-80-28367582-83 Fax : +91-80-28367581xcyton2002@yahoo.co.inxcytondiagnostics@gmail.com

Shubha R PhadkeProfessor, Department of Medical GeneticsSanjay Gandhi Postgraduate Institute of Medical SciencesLucknow - 226 014, IndiaTel: +91-522-2668800, 2668005 to 8 Extn: 2325(O), 2562(R) Fax: +91-522-266801 14S K GuptaNational Institute of ImmunologyAruna Asaf Ali Marg, New Delhi - 110 067Tel: +91-11-26703509skgupta@nii.res.in

M. Radhakrishna PillaiDirectorRajiv Gandhi Centre for BiotechnologyThiruvananthapuram- 695 014, IndiaTel: +91-471-2347973 Fax: +91-471-2349303(www.rgcb.res.in)

mailto:xcyton2002@yahoo.co.inmailto:xcyton2002@yahoo.co.inmailto:xcytondiagnostics@gmail.commailto:xcytondiagnostics@gmail.commailto:skgupta@nii.res.inmailto:skgupta@nii.res.inmailto:skgupta@nii.res.inmailto:xcytondiagnostics@gmail.commailto:xcyton2002@yahoo.co.in

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mrpillai@rgcb.res.in, mrpillai@gmail.com

Chander P PuriChief Executive Officer

Yashraj Biotechnology LimitedPlot No.C-232, TTC Industrial Area, MIDC, Navi Mumbai400 705Tel: +91-22-27681949/6285/6226 Fax: +91-22-27686087Website: www.yashraj.comvichin@vsnl.com

D Prasada RaoDirectorNizams Institute of Medical SciencesPanjagutta, Hyderabad500 082.Tel: +91-40-23489000

Fax : +91-40- 23310076director.nims@ap.nic.in

B RavindranDirectorInstitute of Life Sciences,Nalco Square, Bhubaneswar - 751 023Tel: +91-674-2300137/ 2301476 Ext. 204 Fax: +91-674-2300728balaravi@ils.res.inravindran8@gmail.com

D Nageshwar ReddyAsian Institute of Gastroenterology6-3-661, Somajiguda,Hyderabad500 082.Tel: +91-40-23378888

Rajiv SarinDirectorAdvanced Centre for Treatment, Research and Education in CancerTata Memorial Centre, Kharghar, Navi Mumbai410 208Tel: +91-22-27405035rsarin@actrec.gov.in

M.S.SeshadriProfessor & Head Department of Endocrinology,CMC Hospital, Vellore - 632 004, IndiaTel: +91-416-222102 Extn 2528, 2181 Fax: +91-416 232035,232103,232054endocrine@cmcvellore.ac.in

B Somaraju

mailto:vichin@vsnl.commailto:vichin@vsnl.commailto:director.nims@ap.nic.inmailto:director.nims@ap.nic.inmailto:balaravi@ils.res.inmailto:balaravi@ils.res.inmailto:ravindran8@gmail.commailto:ravindran8@gmail.commailto:endocrine@cmcvellore.ac.inmailto:endocrine@cmcvellore.ac.inmailto:endocrine@cmcvellore.ac.inmailto:ravindran8@gmail.commailto:balaravi@ils.res.inmailto:director.nims@ap.nic.inmailto:vichin@vsnl.com

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CMD, CARE HospitalsHyderabaddrbsomaraju@hotmail.com

Shri Kumar SuryanarayanDirector General

Association of Biotechnology Led Enterprises (ABLE), BengaluruTel : +91-80-41636853 Fax : +91-80-25533938Website :www@ableindia.orgshri@ableindia.org

Nikhil TandonEndocrinologist, Dept of EndocrinologyAll India Institute of Medical SciencesAnsari Nagar, New Delhi110 029Tel: +91-11-20588500/700nikhil2811tandon@gmail.com; ntandon@aiims.ac.in

PARTICIPANTS FROM NORTH AMERICA

Charles Buck Purdue UniversityBindley Bioscience Center1203 West State StreetWest Lafayette, IN 47907-2057cbuck@purdue.edu

Satish GargProfessor of Medicine and PediatricsBarbara Davis Center for Diabetesat the University of Colorado Health Sciences CenterDenver, Colorado, USAMail Stop: A140 P.O. Box 6511 Aurora, CO 80045-6511, USATel: 303-724-6713 (Work) or 303-724-6770 Fax: 303-724-6784satish.garg@uchsc.edu

David HaakeAssociate Professor of MedicineDavid Geffen School of Medicine at UCLADivision of Infectious Diseases,111F VA Greater Los Angeles Healthcare System11301 Wilshire Blvd, Los Angeles, CA 90073, USAFax: (310) 268-4928dhaake@ucla.edu

James W HansonDirectorNational Institute of Child Health & Human Development6100, Executive Blvd Room 4A05MSC 7510, Bethesda MD 20892-7510 USA

mailto:Hyderabaddrbsomaraju@hotmail.commailto:Hyderabaddrbsomaraju@hotmail.commailto:cbuck@purdue.edumailto:cbuck@purdue.edumailto:satish.garg@uchsc.edumailto:satish.garg@uchsc.edumailto:dhaake@ucla.edumailto:dhaake@ucla.edumailto:dhaake@ucla.edumailto:satish.garg@uchsc.edumailto:cbuck@purdue.edumailto:Hyderabaddrbsomaraju@hotmail.com

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Tel : +001-301-496-8535hansonj@mail.nih.gov

Craig LehmannDean of School of Health Technology and ManagementStony Brook University

L2-402 Health Sciences CenterStony Brook, NY 11794-8200Tel: (613) 444-2253Craig.Lehmann@stonybrook.edu

Thomas MampillyFogarty International Center31 Center DriveMSC 2220Bethesda, MD 20892Tel: (301) 402-6212

mampillyt@mail.nih.gov

John McDevittProfessor of Chemistry and BiochemistryCollege of Natural SciencesThe University of Texas at Austin, Austin, Texas, USATel: 512-471-0046 or 512-471-3654Website:http://www.cm.utexas.edu/directory/john_mcdevitt/mcdevitt@mail.utexas.edu

Roderic PettigrewDirectorNational Institute of Biomedical Imaging and BioengineeringNational Institutes of HealthDemocracy Plaza II, Suite 200Tel: 301-451-6768pettigrr@mail.nih.gov

Rebecca Richards-KortumStanley C. Moore Professor of Bioengineeringand Chair, Department of BioengineeringRice University, Houston, Texas, USArkortum@rice.edu

John A. RowlandsSenior Scientist, Sunnybrook Research InstituteProfessor, Departments of Medical Biophysics,Radiation Oncology and Medical ImagingUniversity of TorontoSunnybrook Health Sciences Centre,Toronto, Ontario, Canada.Tel: (416) 480-5708

mailto:hansonj@mail.nih.govmailto:hansonj@mail.nih.govmailto:Craig.Lehmann@stonybrook.edumailto:Craig.Lehmann@stonybrook.edumailto:mampillyt@mail.nih.govmailto:mampillyt@mail.nih.govhttp://www.cm.utexas.edu/directory/john_mcdevitt/http://www.cm.utexas.edu/directory/john_mcdevitt/http://www.cm.utexas.edu/directory/john_mcdevitt/mailto:mcdevitt@mail.utexas.edumailto:mcdevitt@mail.utexas.edumailto:pettigrr@mail.nih.govmailto:pettigrr@mail.nih.govmailto:rkortum@rice.edumailto:rkortum@rice.edumailto:rkortum@rice.edumailto:pettigrr@mail.nih.govmailto:mcdevitt@mail.utexas.eduhttp://www.cm.utexas.edu/directory/john_mcdevitt/mailto:mampillyt@mail.nih.govmailto:Craig.Lehmann@stonybrook.edumailto:hansonj@mail.nih.gov

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john.rowlands@sunnybrook.ca

Nimmi RamanujamDuke University

Biomedical Engineering Department at Pratt School of EngineeringBox 90281Durham, NC 27708-0281Tel: (919) 660-5307nimmi@duke.edu

Kent StevensJohns Hopkins UniversityDepartment of Surgery600 North Wolfe StreetHalsted 608Baltimore, MD 21287

Tel: 410-955-5544Fax: (410) 614-3833ksteve14@jhmi.edu

Jayant A. TalwalkarAssociate Professor of MedicineGastroenterology and Mayo Clinic Transplant CenterMayo Clinic,Rochester, Minnesota, USAtalwalkar.jayant@mayo.edu

Mehmet TonerProfessor of Surgery (Biomedical Engineering) andHealth Sciences & Technology,Harvard Medical School, Massachusetts General Hospital, Cambridge, MA, USATel:617-371-4883mtoner@hms.harvard.eduBernhard WeiglPATH (Program for Appropriate Technologies in Health)Seattle, Washington, USAbweigl@path.org

Richard WestPresident and CEOAdvanced Liquid LogicTel: (919) 287-9010RWest@Liquid-Logic.com

Changhuei YangAssistant Professor of Electrical Engineering and BioengineeringCalifornia Institute of Technology1200 East California Blvd., MS 136-93Pasadena, CA 91125 USA

mailto:john.rowlands@sunnybrook.camailto:john.rowlands@sunnybrook.camailto:nimmi@duke.edumailto:nimmi@duke.edumailto:nimmi@duke.edumailto:ksteve14@jhmi.edumailto:ksteve14@jhmi.edumailto:talwalkar.jayant@mayo.edumailto:talwalkar.jayant@mayo.edumailto:617-371-4883mtoner@hms.harvard.edumailto:617-371-4883mtoner@hms.harvard.edumailto:617-371-4883mtoner@hms.harvard.edumailto:bweigl@path.orgmailto:bweigl@path.orgmailto:RWest@Liquid-Logic.commailto:RWest@Liquid-Logic.commailto:RWest@Liquid-Logic.commailto:bweigl@path.orgmailto:617-371-4883mtoner@hms.harvard.edumailto:talwalkar.jayant@mayo.edumailto:ksteve14@jhmi.edumailto:nimmi@duke.edumailto:john.rowlands@sunnybrook.ca

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MC 136-93, 13 MooreTel: (626)395-8922chyang@caltech.edu

WORKSHOP MODERATORS

J GowrishankarDirectorCentre for DNA Fingerprinting and DiagnosticsECIL Road, Nacharam, Hyderbad500076Tel : +91-40-27155605 Email :director@cdfd.org.in

T S RaoAdviserDepartment of BiotechnologyMinistry of Science and Technology

Block-2, 7th Floor, CGO Complex, Lodhi Road, New Delhi 110 003Tel : +91-11-24364065Email :tsrao@dbt.nic.in

John W. HallerLiaison for International ActivitiesNational Institute of Biomedical Imaging and BioengineeringNational Institutes of Health6707 Democracy Blvd. Suite 200 Bethesda, MD 20892-5649Tel: 301.451.4780 Fax: 301.480.1614hallerj@mail.nih.gov

William J. HeetderksDirector, Extramural Science ProgramsNational Institute of Biomedical Imaging and BioengineeringNational Institutes of HealthDemocracy Plaza II, Suite 200Tel: 301-451-4772 Fax: 301-480-1614heetderw@mail.nih.gov

Brenda KorteProgram DirectorNational Institute of Biomedical Imaging and BioengineeringNational Institutes of HealthDemocracy Plaza II, Suite 200Tel: 301-451-4778 Fax: 301-480-1614kortebr@mail.nih.gov

Alka SharmaJoint DirectorDepartment of BiotechnologyMinistry of Scienmce & Technology

mailto:395-8922chyang@caltech.edumailto:395-8922chyang@caltech.edumailto:395-8922chyang@caltech.edumailto:director@cdfd.org.inmailto:director@cdfd.org.inmailto:tsrao@dbt.nic.inmailto:tsrao@dbt.nic.inmailto:tsrao@dbt.nic.inmailto:hallerj@mail.nih.govmailto:hallerj@mail.nih.govmailto:heetderw@mail.nih.govmailto:heetderw@mail.nih.govmailto:kortebr@mail.nih.govmailto:kortebr@mail.nih.govmailto:kortebr@mail.nih.govmailto:heetderw@mail.nih.govmailto:hallerj@mail.nih.govmailto:tsrao@dbt.nic.inmailto:director@cdfd.org.inmailto:395-8922chyang@caltech.edu

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Block2 (7th Floor), CGO Complex, Lodhi Road, New Delhi110 003Tel: +91-11-24363699alka@dbt.nic.in

Rakesh Agarwal

Dept of GastroenterologySanjay Gandhi Postgraduate InstituteOf Medical Sciences, Raebareli RoadLucknow226 014Tel: 0522-2668004/2668008Email:rakesh@sgpgi.ac

N G Badari NarayanManaging DirectorRelisys Medical Devices LtdPlot No.82, Road No.6

Arunodaya Nagar, NagoleHyderabad500 068Tel: +91-40-23493311Fax: +91-40-24222206Email:ngbadari@gmail.com

M K BhanSecretaryDepartment of BiotechnologyMinistry of Science & TechnologyBlock-2 (7th Floor), CGO Complex, Lodi Road

New Delhi - 110 003Tel: +91-11-24362950Fax: +91-11-24360747Email:mkbhan@dbt.nic.in

Balram BhargavaProfessorDepartment of CardiologyCardiothoracic Sciences CentreExecutive DirectorStanford India Biodesign Programme

All India Institute of Medical Sciences, New Delhi110029, INDIA,Tel: +91-11-26588663Fax: +91-11-26588641Email:balrambhargava@yahoo.com

Shama BhatManaging DirectorBhat Biotech India (P) Ltd, No.11-A, 4

thCross

Veerasandra Industrial Area

mailto:alka@dbt.nic.inmailto:alka@dbt.nic.inmailto:rakesh@sgpgi.acmailto:rakesh@sgpgi.acmailto:rakesh@sgpgi.acmailto:ngbadari@gmail.commailto:ngbadari@gmail.commailto:ngbadari@gmail.commailto:mkbhan@dbt.nic.inmailto:mkbhan@dbt.nic.inmailto:mkbhan@dbt.nic.inmailto:balrambhargava@yahoo.commailto:balrambhargava@yahoo.commailto:balrambhargava@yahoo.commailto:balrambhargava@yahoo.commailto:mkbhan@dbt.nic.inmailto:ngbadari@gmail.commailto:rakesh@sgpgi.acmailto:alka@dbt.nic.in

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Electronics CityBengaluru560100Email:Bharatbiotech@vsnl.com

Suresh Devasahayam

Professor of BioengineeringChristian Medical CollegeVellore 632002Ph. +91-416-228 4298Emailsurdev@cmcvellore.ac.in

T S GanesanDept. of Medical OncologyAmrita Institute of Medical Sciences& Research CentreAmrita Lane, Etamakkara post

KochiKerala682 026Tel: 04842801234, 2804321Fax: 04842802020Email:tsganesan@aims.amrita.edu

Satish K. GargProfessor of Medicine and PediatricsBarbara Davis Center for Diabetes at the University of Colorado Health Sciences CenterDenver, Colorado, USAMail Stop: A140P.O. Box 6511Aurora, CO 80045-6511, USATel: (303) 724-6713 (Work) or (303) 724-6770Email:Satish.Garg@UCHSC.edu

S K GuptaNational Institute of ImmunologyAruna Asaf Ali Marg, New Delhi.Tel # +91-11-26703509Email:skgupta@nii.res.in

David HaakeAssociate Professor of MedicineDavid Geffen School of Medicine at UCLADivision of Infectious Diseases, 111FVA Greater Los Angeles Healthcare System11301 Wilshire BlvdLos Angeles, CA 90073, USAFax (310)268-4928Emaildhaake@ucla.edu

mailto:Bharatbiotech@vsnl.commailto:Bharatbiotech@vsnl.commailto:Bharatbiotech@vsnl.commailto:surdev@cmcvellore.ac.inmailto:surdev@cmcvellore.ac.inmailto:surdev@cmcvellore.ac.inmailto:tsganesan@aims.amrita.edumailto:tsganesan@aims.amrita.edumailto:tsganesan@aims.amrita.edumailto:Satish.Garg@UCHSC.edumailto:Satish.Garg@UCHSC.edumailto:Satish.Garg@UCHSC.edumailto:skgupta@nii.res.inmailto:skgupta@nii.res.inmailto:skgupta@nii.res.inmailto:dhaake@ucla.edumailto:dhaake@ucla.edumailto:dhaake@ucla.edumailto:dhaake@ucla.edumailto:skgupta@nii.res.inmailto:Satish.Garg@UCHSC.edumailto:tsganesan@aims.amrita.edumailto:surdev@cmcvellore.ac.inmailto:Bharatbiotech@vsnl.com

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James W HansonDirectorNational Institute of Child Health & Human Development6100, Executive Blvd Room 4A05

MSC 7510, Bethesda MD 20892-7510Tel: +001-301-496-8535Email:hansonj@mail.nih.gov

C C KarthaCardiologistSree Chitra Tirunal Institute of MedicalSciences & TechnologyThiruvananthapuram695 011KeralaTel: 471-2524400, 2443085

David KelsoAssociate ProfessorNorthwestern University2145 Sheridan Road, E310Evanston, IL 60208-3107Phone: 847-467-2167Fax: 847-491-4928kels@northwestern.edu

Navin KhannaInternational Centre for Genetic Engineering & Biotechnology,P O Box: 10504,Aruna Asaf Ali Marg,New Delhi110 067.Tel: +91-11-2674135/61Fax: +91-11-26742316Email: navin2icgeb.res.in

N Krishna ReddyManaging DirectorCARE Hospitals, Road No.1, Banjara Hills,Hyderabad500034.Tel 040-30418888,Fax 040-30418488

Shri Kumar SuryanarayanDirector GeneralAssociation of Biotechnology Led Enterprises (ABLE)BengaluruTel: +91-80-41636853, Fax: +91-80-25533938Website:www@ableindia.org

mailto:hansonj@mail.nih.govmailto:hansonj@mail.nih.govmailto:hansonj@mail.nih.govmailto:kels@northwestern.edumailto:kels@northwestern.edumailto:www@ableindia.orgmailto:www@ableindia.orgmailto:www@ableindia.orgmailto:www@ableindia.orgmailto:kels@northwestern.edumailto:hansonj@mail.nih.gov

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Email:shri@ableindia.org

Lakshmaiah AAssistant Director

Social and Preventive MedicineNational Institute of NutritionJamai-Osmania PostTaranaka, Hyderabad500 007Ph: 27008921, Extn. 277Fax: 27018904Email:abulalaxman@yahoo.com

Craig Lehmann, Ph.D.Dean of School of Health Technology and ManagementStony Brook University

L2-402 Health Sciences CenterStony Brook, NY 11794-8200Email:Craig.Lehmann@stonybrook.edu

Thomas MampillyFogarty International Center, NIH31 Center DriveMSC 2220Bethesda, MD 20892

John McDevittProfessor of Chemistry and BiochemistryChemistry and BiochemistryCollege of Natural SciencesThe University of Texas at AustinAustin, Texas, USATel: 512-471-0046 or 512-471-3654E-mail: mcdevitt@mail.utexas.eduWebsite: http://www.cm.utexas.edu/directory/john_mcdevitt/

Anoop MisraDirectorDept. of Diabetes & Metabolic disordersFortis HospitalNew Delhi

Mahesh C MisraProfessor & Head,Head, Minimal Access Surgery Unit,Incharge, Breast cancer Clinic,Department of Surgical DisciplinesAnd

mailto:abulalaxman@yahoo.commailto:abulalaxman@yahoo.commailto:abulalaxman@yahoo.commailto:Craig.Lehmann@stonybrook.edumailto:Craig.Lehmann@stonybrook.edumailto:Craig.Lehmann@stonybrook.eduhttp://www.cm.utexas.edu/directory/john_mcdevitt/http://www.cm.utexas.edu/directory/john_mcdevitt/http://www.cm.utexas.edu/directory/john_mcdevitt/mailto:Craig.Lehmann@stonybrook.edumailto:abulalaxman@yahoo.com

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Chief, JPN Apex Trauma Center,All India Institute of Medical Sciences, Ansari Nagar, New Delhi - 110029Phone: +91 11 26594776, 26593206, +91 9811896246, 9868397701, +91 11 26589655,26594531,Fax: +91 11 26588663, 26588641;

E-mail:mcmisra@gmail.com,misramahesh@hotmail.com

V MohanChairman & Chief DiabetologistDr Mohans Diabetes Specialities CentreWHO Collaborating Centre for Non CommunicableDiseases Prevention & ControlPresident & Chief of Diabetes ResearchMadras Diabetics Research FoundationICMR Advanced Centre for Genomics of Diabetes6 B, Conran Smith Road

GopalapuramChennai600086Tel: +91-44-43968888Email:drmohans@vsnl.net

Rakesh MullickProject LeaderGE John F Welch Tech CenterImaging Technology LabEPIP Phase-II, Hoodi VillageWhitefield RoadBangalore560066

D Nageshwar ReddyAsian Institute of Gastroenterology, 6-3-661,Somajiguda, Hyderabad500082.Tel: 23378888

S K PandaProfessor of PathologyAll India Institute of Medical SciencesAnsari NagarNew Delhi110 029Tel # +91-91-26588Email:skpanda@aiims.ac.in&subrat@gmail.com

Roderic PettigrewDirectorNational Institute of Biomedical Imaging and BioengineeringNational Institutes of Health6707 Democracy Blvd. Suite 200Bethesda, MD 20892-5649

mailto:mcmisra@gmail.commailto:mcmisra@gmail.commailto:mcmisra@gmail.commailto:misramahesh@hotmail.commailto:misramahesh@hotmail.commailto:misramahesh@hotmail.commailto:drmohans@vsnl.netmailto:drmohans@vsnl.netmailto:drmohans@vsnl.netmailto:skpanda@aiims.ac.inmailto:skpanda@aiims.ac.inmailto:skpanda@aiims.ac.inmailto:subrat@gmail.commailto:subrat@gmail.commailto:subrat@gmail.commailto:subrat@gmail.commailto:skpanda@aiims.ac.inmailto:drmohans@vsnl.netmailto:misramahesh@hotmail.commailto:mcmisra@gmail.com

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Tel: 301-496-8859Fax: 301-480-4973

E-mail:pettigrr@mail.nih.gov

Shubha R PhadkeProfessorDepartment of Medical GeneticsSanjay Gandhi Postgraduate institute of Medical SciencesLucknow, India 226014Phone +91-522-2668800, 2668005 to 8 ext 2325(o), 2562(r)Fax: +91-522-266801

D Prasada RaoDirectorNizams Institute of Medical Sciences Panjagutta,Hyderabad500082.Tel: +91-40-23489000

Fax: +91-40- 23310076Emaildirector.nims@ap.nic.in

Chander P PuriChief Executive OfficerYashraj Biotechnology LimitedPlot No.C-232, TTC Industrial Area, MIDCNavi Mumbai400705Tel # +91-22-27681949/6285/6226Fax # +91-22-27686087Email:vichin@vsnl.com

Website:www.yashraj.com

M. Radhakrishna PillaiDirectorRajiv Gandhi Centre for BiotechnologyThiruvananthapuram 695014, IndiaPhone: +91 471 2347973Fax: +91 471 2349303Email:mrpillai@rgcb.res.in,mrpillai@gmail.com(www.rgcb.res.in)

Nimmi Ramanujam, Ph.D.Associate ProfessorDuke UniversityBox 90281Durham, NC 27708-0281919-660-5307mimmi@duke.edu

B Ravindran

mailto:pettigrr@mail.nih.govmailto:pettigrr@mail.nih.govmailto:pettigrr@mail.nih.govmailto:director.nims@ap.nic.inmailto:director.nims@ap.nic.inmailto:director.nims@ap.nic.inmailto:vichin@vsnl.commailto:vichin@vsnl.commailto:vichin@vsnl.comhttp://www.yashraj.com/http://www.yashraj.com/http://www.yashraj.com/mailto:mrpillai@rgcb.res.inmailto:mrpillai@rgcb.res.inmailto:mrpillai@rgcb.res.inmailto:mrpillai@gmail.commailto:mrpillai@gmail.commailto:mrpillai@gmail.commailto:mimmi@duke.edumailto:mimmi@duke.edumailto:mimmi@duke.edumailto:mrpillai@gmail.commailto:mrpillai@rgcb.res.inhttp://www.yashraj.com/mailto:vichin@vsnl.commailto:director.nims@ap.nic.inmailto:pettigrr@mail.nih.gov

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DirectorInstitute of Life SciencesNalco Square, Bhubaneswar-751023Ph: 0674-2300137/ 2301476 Ext. 204Fax: 0674-2300728

Email:balaravi@ils.res.inravindran8@gmail.com

B V RavikumarManaging DirectorXcyton Diagnostics Ltd449, 10th Cross, 4th PhasePeenya Industrial AreaBengaluru560058Tel: +91-80-28367582-83Fax: +91-80-28367581

Email:xcyton2002@yahoo.co.in,xcytondiagnostics@gmail.com

Rebecca Richards-KortumStanley C. Moore Professor of Bioengineeringand Chair, Department of BioengineeringRice University6100 Main StreetHouston, TX 77005Email:rkortum@rice.edu

John A. RowlandsSenior Scientist, Sunnybrook Research InstituteProfessor, Departments of Medical Biophysics, Radiation Oncology and Medical ImagingUniversity of TorontoSunnybrook Health Sciences Centre,Toronto, Ontario, Canada.Tel: 416-480-5708Email:john.rowlands@sunnybrook.ca

P Sarat ChandraDept. of NeurosurgeryAll India Institute of Medical SciencesAnsari NagarNew Delhi110 029Email:saratpchandra@aiims.ac.in

Rajiv SarinDirectorAdvanced Centre for Treatment, Researchand Education in CancerTara Memorial Centre, KhargharNavi Mumbai410208

mailto:balaravi@ils.res.inmailto:balaravi@ils.res.inmailto:balaravi@ils.res.inmailto:ravindran8@gmail.commailto:ravindran8@gmail.commailto:info@xcyton.commailto:info@xcyton.commailto:xcytondiagnostics@gmail.commailto:xcytondiagnostics@gmail.commailto:xcytondiagnostics@gmail.commailto:rkortum@rice.edumailto:rkortum@rice.edumailto:rkortum@rice.edumailto:john.rowlands@sunnybrook.camailto:john.rowlands@sunnybrook.camailto:john.rowlands@sunnybrook.camailto:saratpchandra@aiims.ac.inmailto:saratpchandra@aiims.ac.inmailto:saratpchandra@aiims.ac.inmailto:saratpchandra@aiims.ac.inmailto:john.rowlands@sunnybrook.camailto:rkortum@rice.edumailto:xcytondiagnostics@gmail.commailto:info@xcyton.commailto:ravindran8@gmail.commailto:balaravi@ils.res.in

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Tel # +91-22-27405035Email:rsarin@actrec.gov.in

M.S. SeshadriProfessor & Head Department of Endocrinology,

CMC Hospital, Vellore, India 632004Tel 91 416 222102 Extn 2528, 2181Fax 0416 232035,232103,232054Email:endocrine@cmcvellore.ac.in

Kent StevensAssistant ProfessorJohns HopkinsDepartment of Surgery600 North Wolfe StreetHalsted 608

Baltimore, MD 21287Office: 410-955-5544Fax: 410-614-3833Ksteve14@jhmi.edu

Jayant A. TalwalkarAssociate Professor of MedicineGastroenterology and Mayo Clinic Transplant CenterMayo ClinicRochester, Minnesota, USAEmail:talwalkar.jayant@mayo.edu

Mehmet TonerProfessor of Surgery (Biomedical Engineering) andHealth Sciences & Technology,Harvard Medical SchoolMassachusetts General HospitalCambridge, MA, USATel: 617-371-4883Email:mtoner@hms.harvard.edu

Nikhil TandonEndocrinologist, Dept of EndocrinologyAll India Institute of Medical SciencesAnsari NagarNew Delhi110 029Tel # +91-11-20588500/700Email:nikhil2811tandon@gmail.comntandon@aiims.ac.in

Abhi VaseCo-Founder, MicroClinic

mailto:rsarin@actrec.gov.inmailto:rsarin@actrec.gov.inmailto:rsarin@actrec.gov.inmailto:endocrine@cmcvellore.ac.inmailto:endocrine@cmcvellore.ac.inmailto:endocrine@cmcvellore.ac.inmailto:Ksteve14@jhmi.edumailto:Ksteve14@jhmi.edumailto:talwalkar.jayant@mayo.edumailto:talwalkar.jayant@mayo.edumailto:talwalkar.jayant@mayo.edumailto:mtoner@hms.harvard.edumailto:mtoner@hms.harvard.edumailto:mtoner@hms.harvard.edumailto:nikhil2811tandon@gmail.commailto:nikhil2811tandon@gmail.commailto:nikhil2811tandon@gmail.commailto:ntandon@aiims.ac.inmailto:ntandon@aiims.ac.inmailto:ntandon@aiims.ac.inmailto:nikhil2811tandon@gmail.commailto:mtoner@hms.harvard.edumailto:talwalkar.jayant@mayo.edumailto:Ksteve14@jhmi.edumailto:endocrine@cmcvellore.ac.inmailto:rsarin@actrec.gov.in

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687 Rustic LaneMountain View, CA 94040(650) 387-5948Email:abhi.vase@gmail.com

Bernhard WeiglDirector, PATH Diagnostics GroupPATH (Program for Appropriate Technologies in Health)1455 NW Leary WaySeattle, Washington, 98107Email:bweigl@path.org

Changhuei Yang, Ph.D.Assistant Professor of Electrical Engineering and BioengineeringCalifornia Institute of TechnologyBiophotonics Laboratory

MC 136-93, Moore1200 E. California Blvd.Pasadena, CA 91125chyang@caltech.edu

mailto:abhi.vase@gmail.commailto:abhi.vase@gmail.commailto:abhi.vase@gmail.commailto:bweigl@path.orgmailto:bweigl@path.orgmailto:bweigl@path.orgmailto:chyang@caltech.edumailto:chyang@caltech.edumailto:chyang@caltech.edumailto:bweigl@path.orgmailto:abhi.vase@gmail.com

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Workshop Sponsors

Indo-U.S. Science and Technology ForumFulbright House, 12 Hailey Road, New Delhi 110 001, India

Website: www.indousstf.org

The Indo-U.S. Science and Technology Forum (IUSSTF) was established in 2000 under anagreement between the Governments of India and United States of America with a mandate topromote, catalyze and seed bilateral collaboration in science, technology, engineering and biomedicalresearch through substantive interaction amongst government, academia and industry.

As its mandate, IUSSTF provides an enabling platform to the scientific enterprises of the two nationsby supporting an S&T program portfolio that is expected to foster sustainable interactions with apotential to forge long term collaborations. IUSSTF program manifests are largely catalytic in naturethat helps to create awareness through exchange and dissemination of information and opportunities inpromoting bilateral scientific and technological cooperation.

IUSSTF has an evolving program portfolio that is largely conceived and driven by scientific

communities of both the countries through extending support for symposia, workshops, conferences ontopical and thematic areas of interest; visiting professorships and exchange programs; travel grants;fellowships; advanced training schools; public-private networked centres and knowledge R & Dnetworked centres. IUSSTF also works towards nurturing contacts between young and mid careerscientists by convening stimulating flagship events like the Frontiers of Science and Frontiers ofEngineering symposium through the U.S. National Academies model. At the same time it reaches outto industries by partnering with business associations to generate high quality events on technologyopportunities for business development to foster elements of innovation and enterprise throughnetworking between academia and industry.

IUSSTF maintains a close working relationship with the federal agencies, laboratories, government

institutions, and the academia in U.S. and India, cutting across all disciplines. As an autonomous, not-for-profit society, IUSSTF has the ability, agility and flexibility to engage and involve industry, privateR&D labs; and non governmental entities in its evolving activity manifold. This operationaluniqueness allows the IUSSTF to receive grants and contributions from independent sources both inIndia and USA, besides the assured core funding from the two governments.

IUSSTF solicits proposals for its activities thrice a year (January, May and September) and awards aremade on the basis of peer reviews both in India and USA.

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IUSSTF values your interactions and looks forward to work with the S&T community of bothcountries to implement new ideas that endeavor to promote cutting edge Indo-U.S. Science andTechnology collaborations.

National Institute of Biomedical Imaging and Bioengineering

National Institutes of Health

U.S. Department of Health and Human Services

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) is dedicated toimproving human health through the integration of the physical and biological sciences. The researchagenda of the NIBIB will dramatically advance the Nations health by improving the detection,management, understanding, and ultimately, the prevention of disease.

Created December 29, 2000, the NIBIB is part of the National Institutes of Health (NIH), within theDepartment of Health and Human Services; the Federal governments premier biomedical researchagency. NIBIB-supported research brings advances in fields ranging from physics to nanotechnologyto bear on the challenges of diagnosing, preventing and treating disease. Ultimately, the NIBIB seeksto translate research findings from the laboratory to the patient to improve quality of life and reducethe burden of disease. Health care and technology have long been linked in the United States. Today,cardiac pacemakers, mammograms, sustained-release medications, and artificial hips are but a fewexamples of how biomedical imaging and bioengineering are transforming health care.

Biomedical imaging is an indispensable tool for the diagnosis and treatment of a variety of diseases. In

the early twentieth century, incremental advances in imaging were achieved at a relatively slow rate.However, in the last 40 years, improvements and new discoveries in imaging technology haveoccurred much more rapidly. The x-rays of over 100 years ago have been replaced by the discovery ofultrasound, optical imaging, computed tomography (CT), and magnetic resonance imaging (MRI).Now, researchers and physicians can choose to image not only the entire body or individual organs,but even specific cells or molecules within an organ or tissue.

NIBIB is building on these advances by supporting pioneering research to develop new technologiesand to improve existing imaging systems. For example, an NIBIB-supported scientist is using

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sophisticated imaging technologies to improve surgical techniques for treating weakened knees andjoints.

These are just a few examples of the imaging and bioengineering projects under way. Other examplesof innovative technologies supported by the NIBIB include:

Ways to treat medical problems based on an individuals genetic makeup.

Light-based tools used in medicine and surgery that provide new ways to study, diagnose, andtreat medical problems.

Smart sensors that use chemical and physiological signals from the body to release drugs at theright dose in the right place at the right time.

New imaging technologies and improvements in existing technologies to improve thediagnosis and treatment of many diseases.

Drug delivery devices such as microneedles to painlessly deliver drugs and implantabledevices that release drugs as needed.

Tissue engineering research to promote the growth of skin on burn victims, restore vision indamaged eyes, and generate new organs for transplant.

The NIBIB is committed to driving medical innovation and expanding biomedical knowledgefor this and future generations. The Institute envisions a day when disease is preventable,health is predictable, and many of todays medical treatments are a thing of the past.

Department of Biotechnology, Ministry of Science and Technology

Republic of India

The setting up of a separate Department of Biotechnology (DBT), under the Ministry of Science andTechnology in 1986 gave a new impetus to the development of the field of modern biology andbiotechnology in India. In more than a decade of its existence, the department has promoted andaccelerated the pace of development of biotechnology in the country. Through several R&D projects,demonstrations and creation of infrastructural facilities a clear visible impact of this field has beenseen. The department has made significant achievements in the growth and application ofbiotechnology in the broad areas of agriculture, health care, animal sciences, environment, andindustry.

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The impact of the biotechnology related developments in agriculture, health care, environment andindustry, has already been visible and the efforts are now culminating into products and processes.More than 5000 research publications, 4000 post-doctoral students, several technologies transferred toindustries and patents filed including US patents, can be considered as a modest beginning.Department of Biotechnology (DBT) has been interacting with more than 5,000 scientists per year in

order to utilise the existing expertise of the universities and other national laboratories. A very strongpeer reviewing and monitoring mechanism has been developed. There has been close interaction withthe State Governments particularly through State S & T Councils for developing biotechnologyapplication projects, demonstration of proven technologies, and training of human resource in Statesand Union Territories. Programmes with the states of Gujarat, Rajasthan, Madhya Pradesh, Orissa,West Bengal, Haryana, Punjab, Jammu & Kashmir, Mizoram, Andhra Pradesh and Uttar Pradesh havebeen evolved. Biotechnology Application Centres in Madhya Pradesh and West Bengal have alreadybeen started.

A unique feature of the department has been the deep involvement of the scientific community of thecountry through a number of technical task forces, advisory committees and individual experts inidentification, formulation, implementation and monitoring of various programmes and activities.

In India, more than a decade of concerted effort in research and development in identified areas ofmodern biology and biotechnology have given rich dividends. The proven technologies at thelaboratory level have been scaled up and demonstrated in field. Patenting of innovations, technologytransfer to industries and close interaction with them have given a new direction to biotechnologyresearch. Initiatives have been taken to promote transgenic research in plants with emphasis on pestand disease resistance, nutritional quality, silk-worm genome analysis, molecular biology of humangenetic disorders, brain research, plant genome research, development, validation andcommercialisation of diagnostic kits and vaccines for communicable diseases, food biotechnology,biodiversity conservation and bioprospecting, setting up of micropropagation parks and biotechnologybased development for SC/ST, rural areas, women and for different States.

Necessary guidelines for transgenic plants, recombinant vaccines and drugs have also been evolved. Astrong base of indigenous capabilities has been created. The field of biotechnology both for newinnovations and applications would form a major research and commercial endeavor for socio-economic development in the next millennium.

Acknowledgements

The authors of this report would like to acknowledge the support and contributions of the Indo-U.S.Science and Technology Forum; the National Institute of Biomedical Imaging and Bioengineering of

the National Institutes of Health in the United States Department of Health and Human Services; theDepartment of Biotechnology (DBT) of the Ministry of Science and Technology in the Republic ofIndia; and the Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India. In addition, theauthors would like to acknowledge the efforts of Dr. M. K. Bhan, Secretary to the Government ofIndia, Department of Biotechnology, Ministry of Science and Technology, New Delhi, and Dr.Roderic Pettigrew, Director of the National Institute of Biomedical Imaging and Bioengineering, NIH,Bethesda, Maryland. Finally, we would like to acknowledge the many ideas and recommendationscontributed by the workshop participants listed in this report above.

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Authors

John Haller, NIBIB/NIH T.S. Rao, DBT

William Heetderks, NIBIB/NIH Alka Sharma, DBT

Brenda Korte, NIBIB/NIH J Gowrishankar, CDFD

P. Janila, CDFD