Discussion: The results of this study confirm the associationbetween MPA and schizophrenia. The excess of MPAs in schizo-phrenia is in agreement with the neurodevelopmental hypothesis ofthis disorder that posits a role for genetic and environmental factorsin the development of the disorder during critical intrauterine andperinatal periods.

doi:10.1016/j.schres.2010.02.253

Poster 26IMPROVING DETECTION OF FIRST EPISODE PSYCHOSISBY MENTAL HEALTH CARE SERVICES USING A SELFREPORT QUESTIONNAIRE

NynkeBoonstra1,2,3, LexWunderink1,2, Sjoerd Sytema2,DurkWiersma21Friesland Mental Health services Leeuwarden, Friesland, Netherlands;2University Center of Psychiatry, University medical Center Groningen,Groningen, Netherlands; 3NHL University of Applied science Leeuwarden,Friesland, Netherlands

Background: To examine the utility of the Community Assessmentof Psychic Experiences (CAPE)-42, a self report questionnaire, toimprove detection of the first episode psychosis in new referrals tomental health services.Methods: At first contact with mental health care services patientswere asked to complete the CAPE-42 and were than routinelydiagnosed by a clinician. Standard diagnosis were obtained by meansof the mini- Schedule for Clinical Assessment in Neuropsychiatry.Results: Of the 246 included patients, 26 (10.6%) were diagnosedwith psychosis according to the mini- Schedule for ClinicalAssessment in Neuropsychiatry. Only 10 of them were recognizedby clinical routine, and 16 psychotic patients were not properlyidentified. Using an optimal cut-off of 50 on the frequency ordistress dimension of the positive subscale of the CAPE-42, detected14 of these misdiagnosed patients. The sensitivity of the CAPE-42 atthis cut-off point was 77.5 and the specificity was 70.5.Discussion: We found that in routine clinical practice patients werenot appropriately recognized leaving a substantial number ofpsychotic patients undetected. Implementation of systematicscreening using a self report questionnaire for psychotic symptomsimproves routine detection of psychotic patients when they firstcome into contact with mental health services.

doi:10.1016/j.schres.2010.02.254

Poster 27PARENTAL AGE AND THE RISK OF PSYCHIATRIC DISORDERS

Jacobine E. Buizer-Voskamp1,2, Wijnand Laan3, Marco P.M. Boks1,3,Wouter G. Staal4, Eric A.M. Hennekam5, Maartje F. Aukes1,3,Rene S. Kahn1, Roel A. Ophoff2,61Rudolf Magnus Institute of Neuroscience, Department of Psychiatry,University Medical Center Utrecht Utrecht, Utrecht, Netherlands;2Complex Genetics Section, Department of Medical Genetics, UniversityMedical Center Utrecht Utrecht, Utrecht, Netherlands; 3Julius Center forHealth Sciences and Primary Care, University Medical Center UtrechtUtrecht, Utrecht, Netherlands; 4Department of Child and AdolescentPsychiatry, UniversityMedical Center Utrecht Utrecht, Utrecht, Netherlands;5Department of Clinical Genetics, UniversityMedical Center Utrecht Utrecht,Utrecht, Netherlands; 6UCLACenter forNeurobehavioralGenetics, Universityof California Los Angeles Los Angeles, California, USA

Background: It has been suggested that increased parental age is a riskfactor for developing psychiatric disorders. Parental agemay be linkedto increased de novo germline mutations or epigenetic changesaffecting neurodevelopment and leading to increased susceptibilityto schizophrenia and other neuropsychiatric disorders in the offspring.So far, studies on this subject have been scarce and oftentimesaccompanied with methodological limitations such as limited samplesize or selective samples. In this study we examine parental age andthe risk for developing different psychiatric disorders includingschizophrenia, bipolar disorder, major depression disorder and autismin the Dutch population using a population-based registry.Methods: Patientswith the diagnoses schizophrenia, bipolar disorder,major depression disorder, and autism are collected through a patientregistry from the central part of The Netherlands. From these patients,date of birth, sex, birth order, and ethnicity are collected. Date of birthfrom their parents is received from the database of Statistics Nether-lands (CBS). Social Economic Status (SES) of the residential area istaken as a proxy for parental education. A fourfold number ofmatchedcontrol subjects is collected from the CBS population database,matched on month and year of birth, residential area, sex, andethnicity. Parental ages at time of birth of the proband is calculated indays and logistic regression is carried out using the followingequation/parameters: Psychiatric diagnoses∼age_father*b1+difference_in_years_with_age_mother*b2+SES*b3.Results: In total, 2,627 Schizophrenic, 2,329 Autistic, 8,634 Majordepression, and 1,133 Bipolar disorder patients were available foranalyses. Data on parental age and the risk for developing thesedisorders will be presented. We hypothesize that the risk fordeveloping a psychiatric diagnosis increases linearly with age of thefather, adjusted for age of the mother, age difference between parentsand socio-economic status. Previous studies indicated that schizo-phrenia is associated with higher paternal age, whereas bipolardisorder and autism seem to be associated with both paternal andmaternal ages. Thus far, no studies reported an association betweenparental age and the risk for major depression disorder.Discussion: Although schizophrenia, bipolar disorder, autism, andmajor depression are heterogeneous disorders, results from theparental age analyses could give more inside in the etiology of thesediseases. If advanced parental age is associated with risk todeveloping psychiatric disorders, we should examine whether denovo genetic mutations or epigenetic mechanisms may contributeto this effect. As far as we are aware, this is the first large-scalepopulation-based study to compare the four main psychiatricdiagnoses on parental age in a single cohort.

doi:10.1016/j.schres.2010.02.255

Poster 28IS TRAUMATIC BRAIN INJURY A RISK FACTOR FOR PSYCHOSIS? ASYSTEMATIC REVIEW AND META-ANALYSIS

Charlene Molloy1, Ronan Conroy2, Dearbhla Connor1, David Cotter1,Mary Cannon1

1Department of Psychiatry, Royal College of Surgeons in Ireland andBeaumont Hospital, Dublin Ireland; 2Department of Epidemiology,Division of Population Health |Sciences, Royal College of Surgeons inIreland Dublin Ireland

Background: Traumatic brain injury (TBI) has long been implicated inthe development of a range of neuropsychiatric disturbances, such ascognitive impairments, mood disorders, anxiety disorder and beha-vioural problems. However the question of whether TBI is a risk factorfor psychosis remains somewhat controversial. To help clarify theevidence we conducted a systematic review and meta-analysis ofavailable studies onpsychosis among individualwhohave sufferedTBI.

Abstracts194