Impact of Herbs and Supplements on the Aging Process

Disclosure

Greg Giant BS Pharm RPhAuthentic Pharmaca PC, President

Mission“Natural approach to wellness and disease management through the use of

nutrition, supplements and lifestyle”

This presentation was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Learning Objectives

• Discuss the principles behind the use of probiotics to stabilize the gut biome

• Describe the principles behind the use of antioxidants to manage free radical production and damaging impact on disease and inflammation

• Explain the impact of nutrition and lifestyle on the wellness of the patient

Understanding the Aging Process

From a wellness perspective,

The goal of aging is to add years to your life…and life to your years

Is “aging” something that you and your patients can affect?

Journal of Cachexia, Sarcopenia and Muscle (2015)

Biomarkers for physical frailty and sarcopenia

state ofthe science and future

developments

“Age-Associated Chronic Diseases Require Age-Old Medicine: Role

of Chronic Inflammation”

Prasad, Sahdeo, et.al Preventive Medicine 54.Suppl (2012): S29–S37.

Sanada F, Taniyama Y, Muratsu J, Otsu R, Shimizu H, Rakugi H and Morishita R 2018) Front. Cardiovasc. Med. 5:12.

Source of Chronic Inflammation in Aging

The Continuum of Aging and Age-

Related Diseases:

Common Mechanisms but Different Rates

Front. Med., 12 March 2018 https://doi.org/10.3389/fmed.2018.00061

REVIEW| VOLUME 28, ISSUE 3, P199-212, MARCH 01, 2017

Nutrition

• EFFECT ON HEALTH – is it only satisfying hunger versus what our body actually needs

• How will it affect my body

• Will the food speed my metabolism and promote muscle growth

• Will it clean and purify my body fluids and tissues

Jame Heskett, The Well Path

Nutrition

ProbioticsPrebiotics

Herbs

Vitamins

Spices

Herbal Medicine

Minerals

AntioxidantAnti-inflammatory

Ayudevic ChineseShamanic

Integrative MedicineFunctional Medicine

Synthetic vs Natural

• Fewer Pharmaceutical Medicines – reduce risk to the GUT with fewer adverse effects impacting inflammation, absorption, and the biome.

• More Prebiotics and Probiotics – can be as effective as mainstream pharmaceuticals with fewer side effects and a greater impact on managing or controlling GUT dysbiosis

• More Herb, Spices and Polyphenols – strong anti-inflammatory and anti-oxidant properties to impact cell and immuno-senescence

Importance of the GUT

GUT

BRAIN

MIND

HEART

Does Bacteria and Fungus help or hurt the GUT?

Symbiotic Relationship

• Microbes protect from dangerous bacteria.

• Microbes works hard to digestfood and create vitamins, manageour hormone levels, dispose of toxins, and create natural chemicals that help feed and protect the lining of the gut.

Good versus Bad

• Probiotic Microbes• Harmful Microbes – offer no benefits• Harm or Help Microbes

• Klebsiella – at low levels they make vitamins B12 and K in the intestines, can cause major lung infections

• Bacteroides – contribute to intestinal health and may digest dietary carbohydrates, can cause bacterial abscesses outside of intestines

Chronic Diseases Caused by Chronic Inflammation Require Chronic Treatment

Anti-inflammatory Role of Dietary Spices

Prasad and Aggarwal, Journal of Clinical Cellular Immunology 2014, 5:4

Rapidly expanding knowledge…

on the role of the gut microbiome inhealth and disease

M.C. Cénit, V. Matzaraki, E.F. Tigchelaar, A. Zhernakova Biochimica et BiophysicaActa 1842 (2014) 1981–1992

Clinical Environmental Factors

• Food

• Stress

• Exercise

• Sleep

…..and the state of the microbiome

Brian Perlmutter, Brain Maker

What makes a yard bad?

What makes a yard healthy?

Autoimmunity

Challenges to Probiotics

• Antibiotics –

• A two week course of a broad spectrum antibiotic can virtually wipe out all the good bacteria

• Low levels of antibiotics may be in meats and water that end up being part of a long term effect impacting intestinal bacteria

• good bacteria grow back slower than bad bacteria – especially if the diet is high in refined carbohydrates and low in prebiotics

Challenges to Probiotics

• American Diet –• 1 of 3 meals eaten away from home with the second meal often prepared

away from home.

• A poor diet versus a healthy diet produce different GUT bacteria

• Healthy diet bacteria break down carginogens better than poor diet bacteria

Questions about Probiotics

• What probiotic is most effective against a particular disease?• What dose should be used?• How long do they take to produce improvements?• Are combinations synergistic?• What is their effect with existing medical therapies?

Probiotics can also be used as part of a preventative strategy –• Protective role acting as a repair force to maintain health• For dysbiosis – from poor GI function coming from body stresses and medications

(antibiotics and NSAIDs)• To reduce symptoms and length of a cold

AGING (LIFESPAN)

How many issues are caused by chronic medication?

Getting back to Earth

• Antibiotics - NO• Antibacterials - NO

• Preservatives, Stabilizers, Additives - NO• We should focus on consuming foods that are

grown in the region where we live.• The microbes found in your local soil will

help you better digest the foods with customized immune defense weaponry to combat pathogens you may be exposed to regularly.

Josh Axe, Eat Dirt

ENVIRONMENTThe Food Chain

SOIL PLANTS ANIMALS KITCHEN

https://cleanairlawncare.com/soil-where-food-begins/

Soil Based Organisms (SBOs)

• Fresh fruit and vegetables from a farmer’s market with soil still coated from soil from the ground

• Bacillus subtilis – heat resistant - potent immune response that promotes healing of the gut lining and suppresses salmonella and other pathogens.

• Bacillus coagulans – heat resistant – improves nutrient absorption –producing lactic acid – reduce inflammation and symptoms of arthritis

• Medicinal Mushrooms – mycelium• Prebiotic, balances microbes in the biome, boosts the immune system,

detoxifying chemicals and heavy metals, inhibits pathological immune functions, reduce histamine release, destroys tumors and cancer cells, fights viruses and candida, reduces stress hormones – reishi, shiitake, cordyceps, lion’s mane, turkey tail.

Josh Axe, Eat Dirt

Getting back to EarthMicrobes from the soilEntered through the skin’s epidermal layer

• Reinforce the good bacteria in the gut• Teach the beneficial bacteria information about responding to pathogens in the local

area• Aid my body in creating nutrients including vitamin b12 and vitamin K• Support my digestion and absorption of minerals• Reduce my inflammation• Help heal or prevent “leaky gut”

Research has shown, having a cat or dog as a kid cuts the incidence of allergies in half

Josh Axe, Eat Dirt

Getting back to Earth

• Eat dirt as supported in over 800 studies

• Soil based organisms(SBO) help with Gut health and immune response• Known to impact…

• Allergies Asthma Bloating Flatulence Nausea• Indigestion Malabsorption Nutrient Deficiency• Autoimmune Disease Inflammatory Disease Bacterial, Fungal and Viral Diseases• Ulcerative colitis Irritable Bowel Syndrome(IBS)

Josh Axe, Eat Dirt

Authentic Pharmaca PC

Jame Heskett, The Well Path

The major sources of free radicals include: (5)•Ordinary body functions, such as breathing and digestion•Even too much exercise…overtraining•High amounts of emotional or physical stress.. cortisol•Exposure to radiation•Exposure to other environmental pollutants•Consumption of cigarettes or tobacco, drugs, and alcohol•Certain medications or high use of antibiotics•A poor diet that includes foods like unhealthy fats, too much sugar, pesticides, herbicides or synthetic additives. Many processed and refined foods contain oxidized fats that add free radicals to the body. Excessive amounts of refined sugar and sweeteners are other sources of free radical growth that contribute to aging, weight gain and inflammation.

Chronic Diseases Caused by Chronic Inflammation

Require Chronic Treatment: Anti-inflammatory Role of

Dietary Spices.

Prasad S, Aggarwal BB (2014) J Clin Cell Immunol 5:238

Tasteful Herbs and Spices

Around the world, herbs and spices add taste and health to any dish that they are used with. The nutrients add these health components:• Antioxidant – scavenges the toxic

effects of the environment and bad food that can cause tissue damage

• Anti-inflammatory – not only impacts protecting the gut, but what impacts chronic disease

• Anti-microbial, anti-viral and anti-parasitic – improves resistance to infection

• Anti-cancer – improves immunity and may actually kill cancer cells

• Cholesterol lowering – helps improved LDL/HDL ratios

• Kidney and Liver protection 36

Hierarchy of Antioxidant / Rust Preventor potency

Only mentioned are products in their original forms – not altered or synthetic[ Herbal Medicine/Supplements ]

[ Dried Herbs and Spices ][ Fresh Herbs and Spices ]

[ Berries/Legumes Products ] [ Nuts and Seeds ]

[ Dark Chocolate ][ Fruits/Vegetables ]

Dk beer/dk wine[

Most potent Herbal Rust preventers

• Peppermint *Allspice• Oregano *Thyme• Sage *Rosemary• Saffron *Estragon• Nutmeg *Turmeric• Ginger *Coriander seed• Clove *Cinnamon

FRESH SAMPLES HAD LOWER VALUES THAN CRUSHED/DRIED SAMPLES,

Ginger

Longest continuous use of any botanical remedy in the world.

Western popularity • Antinausea properties and other stomach problems

like gas, IBS, and diarrhea

Chinese use it for both medicinal and culinary purposes, • cooking seafood -detoxifier to prevent seafood

poisoning

Studied effect• Anti-oxidant and Anti-inflammatory to reduce

aging, • Anti-thrombotic and Anti-cancer

www.mnn.com/food/healthy-eating/stories/the-3-best-spices-for-a-longer-life

39

Turmeric (Curcuma longa) “Spice of Life”

• Anti-inflammatory – no ulcer formation or GI bleeding

• Anti-oxidant –reduces aging

• Lowers cholesterol, suppresses clotting and MI

• Anti-Cancer – effective for most types of cancer

without causing damage to other tissues

• Neuroprotective – Alzheimer’s and Parkinson’s Disease

• Improved Skin Conditions

http://articles.mercola.com/sites/articles/archive/2011/01/31/curcumin40

Oregano (Origanum vulgari)Mediterranean use for thousands of years as well as cuisines in the Philippines and Latin America

• Potent Antioxidant – more than fruits, berries or vegetables

• Anti-inflammatory• Antifungal and Antibacterial – UTIs and Respiratory• Anti-viral - impact on viral upper respiratory infections including

increased secretions to rid phlegm• Anti-cancer – prostate, breast, skin, leukemia and colon

Active Ingredients carvacrol, thymol, limonene, pinene, ocimene, caryophyllene, rosmarinicacid

http://articles.mercola.com/sites/articles/archive/2014/02/01/oregano-health-benefits.aspx

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Dietary PhenolsMicronutrients w/ Antioxidant and Prebiotic Effects

• Beans, Peas, Lentils, • Herbs and Spices – used with or without cooking• Fruit – consumed with the skin• Berries and Juices of dark berries(unfiltered and unsweetened)• Tea, Coffee (up to 3 cups/day)• Dark Beer(ales and stouts), Red Wine• Red Wine vinegar• Dark chocolate and cocoa powder

Network Antioxidants

• These work best as a team vs. individually

http://www.simplyantioxidant.com

Glutathione

Alpha Lipoic Acid CoEnzyme Q10

Vitamin E Vitamin C

Glutathione

Master of the antioxidant family• Detoxifies heavy metals – especially from the liver

• Low levels of glutathione in the blood may be a result of its removal with the heavy metals

• Aids in immunity by stimulating the growth of immune cells in older or chronically ill patients

• Fights cancer – helps to protect DNA and helps prevent the DNA mutations cancer

• Anti-aging – potent antioxidant

http://www.simplyantioxidant.com

Alpha Lipoic Acid (ALA) - Multitasker

Recycles all the NETWORK ANTIOXIDANTs – Universal antioxidant – water and fat soluble

HEALTH BENEFITS• Stroke – helps reduce free radicals from stroke recovery and improve outcomes• Toxic Metals – they are free radicals and ALA binds and deactivates them• Cholesterol – counters the free radicals that binds with LDL causing arterial plaque• Diabetes – helps control blood sugar and repairs nerve peripheral nerve damage caused by

glycation• AGE – diabetes and Alzheimer’s disease has these formations due to excess glucose

binding to protein in the blood which then produces free radicals that attach to nerve cells.

• Heart Disease – ischemia(heart attacks) cause a release of free radicals that can produce additional damage and aging.

http://www.simplyantioxidant.com

Alpha Lipoic Acid (ALA)Health Benefits (cont)• Eye Diseases (Cataracts) –– ALA generates the production of Glutathione

which together prevents cataracts and repairs the damages caused by these free radicals.

• Immune System – bolsters T-cell production which is the first line of immune defense

• Radiation Poisoning – aids in the recovery of radiation which is the result of free radical release

• Mitochondrial Function – combined with l-carnitine improves the absorption into the cell to rejuvenate the mitochondria to improve the production of energy.

• Brain Function –Overstressing the brain produces excessive amounts of free radicals causing damage. ALA and other fat soluble antioxidants help to neutralize these free radicals to improve brain function

http://www.simplyantioxidant.com

The New Kid on the Block

ASTAXANTHIN

Health Benefits• Anti-Inflammatory – Includes chronic inflammation and acute pain and

inflammation from strenuous exercise and free radical production.

• Eye Care – protects against Aged Related Macular Degeneration(AMD) and Diabetic Retinopathy

• Brain Health – Stroke Prevention and Recovery

• Neuro-degenerative Disease – Alzheimer’s Disease and Parkinson’s Disease

• Cardiovascular Health - controlling cholesterol

http://www.simplyantioxidant.com

Summary

• Probiotics and prebiotics are a necessary consideration for the normalization of the gut to minimize inflammation and an adverse immune response that may lead to chronic disease and auto-immune sequella.

• Anti-oxidant foods, herbs and nutritional supplements are a natural defense needed to fortify the body against the extraordinary onslaught of toxins and overstimuli that comes from poor nutrition and lifestyle.

• Malnutrition is a major part leading to Inflammaging and Proper Nutrition staying away from anything processed or synthetic is a suggested way to advise patients to a more robust and prolonged life.

Impact of Herbs and Supplements on the Aging Process

Greg Giant BS Pharm RPh Authentic Pharmaca PC