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I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

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Page 1: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff

(New Orleans, USA)

Page 2: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

ZEBRAFISH NEUROPHENOME PROJECT

The ZNP was started by the ZNRC, and is dedicated toward producing a ZND

Let’s start by defining these acronyms

Page 3: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

The ZNRCZebrafish Neuroscience Research Consortium

Allan Kalueff - USA Georgianna Gould - USA Oliver Braubach - Canada Anderson Manoel Herculano - Brazil David Echevarria - USA Joe Schroeder - USA Jason Warnick - USA Dominic Wright - SwedenCarla Denise Bonan - BrazilMônica Ryff Moreira Roca Vianna - BrazilZofia Zukowska - USA

Page 4: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

The main goal of ZNRC is to promote zebrafish neuroscience research.

Created in February 2010, ZNRC offers excellent networking opportunities and peer support for active zebrafish labs.

Page 5: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

ZNDZebrafish Neurophenome Database

Goals:PioneeringAccessibleEasy to useUseful

Page 6: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

Emerging Model Organism

The Zebrafish is an emerging model animal for vertebrate development and neurological function

Offers a good compliment to other animal models

Advantages Easy to take care of Inexpensive Easy to test Quantifiable behavioral endpoints

Page 7: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

Inspiration

MiceMouse Genome

Informatics (G+P)Mouse Phenome

Database (P)

RatsRat Genome Database

(G)National BioResource

Project (P)

ZebrafishZFIN (Genome)

NCBI (Genome)

The point?

A Phenome database for the Zebrafish does not yet exist, but inevitably will sometime soon

Page 8: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

PubMed search“zebrafish”

1900-1985 - 61 papers

1985-1990 - 114 papers

1990-1995 - 487 papers

1995-2000 - 1981 papers

2000-2005 - 4946 papers

2005-2010 - 7538 papers

Between 2005 and 2010 the total number of zebrafish-related papers ever written doubled.

Page 9: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

ZNDZebrafish Neurophenome Database

Goals:Pioneering (so far)AccessibleEasy to useUseful

Page 10: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

www.kaluefflab.com/znpindex-or-

www.tulane.edu/~znpindex/search

Page 11: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

ZNDZebrafish Neurophenome Database

Goals:Pioneering (so far)Accessible (the internet)Easy to useUseful

Page 12: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

What we see, Not easy

Page 13: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

What you’ll see

Page 14: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

What you’ll see

Page 15: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

What you’ll see

Page 16: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

Everything you need to know… Hopefully

Page 17: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

If not..

Submit your data! More on this later

Page 18: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

How it’s organized

Experiment 1

Interval 1.1

Treatment 1.1.1

Interval 1.2

Interval 1.3

Treatment 1.1.2

Parent/Child Format

Page 19: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

Caffeine L/D Box

15 min

100 mg/kg I.P.

250 mg/kg I.P.

Chronic

Acute withdraw

al

Experiment

Interval

Treatment

Page 20: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

that’s what you’re seeing here

Experiment

IntervalTreatment

TestResults

Page 21: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

ZNDZebrafish Neurophenome Database

Goals:Pioneering (so far)Accessible (the internet)Easy to use (we hope so) Useful

Page 22: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

Only With Your Help

Submit your data! (2 methods)1.Direct info submission with the

submission template (next slide)2.Send us a paper (please use step

#1)

Page 23: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

Submission Template

Page 24: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

If you send us a paper…

Page 25: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

We fill out the template

Page 26: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

ZNDZebrafish Neurophenome Database

Goals:Pioneering (so far)Accessible (the internet)Easy to use (we hope so) Useful (with your help)

Page 27: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

Special Thanks

Budd Hirons - who has been essential to the actualization of this idea.

ILC (Innovative Learning Center) & Tulane University Technology Services

Also, Tulane has been kind enough to supply us with the server space that is required to host such a database.

Page 28: I Zapolsky, E Kyzar, S Gaikwad, A Roth, J Green, M Pham, PG St. Pierre, B Hirons, AV Kalueff (New Orleans, USA)

In Conclusion

The Zebrafish is an emerging animal model for vertebrate development and neurological function

We hope to work closely with other zebrafish-based databases to help provide a better, more comprehensive user experience

Check in regularly at: http://www.tulane.edu/~znpindex/search Or just search ZNP or Zebrafish Phenome

You can help by submitting your data.

http://www.tulane.edu/~znpindex/search

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