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TRANSCRIPT
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a/ o a/
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5^aisijj<uwtiJ'u<uu)?!j'i^wei (effective list)<5s\j'uiJ<3j;n'ua-3Rjj
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effectiveness)
(maximization of cost-
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to/to
(explicit information)
Si^n'W (evidence-based literature)sliiBwmtiuwaVilunnTnmaeniQiimjfniwfo
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(Safety Monitoring Program: SMP)
(off-label indication)
(Safety
SMP
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(Drug Utilization Evaluation, DUE) IflLmaw
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(transparency) TflEJwniaumTufvniu-Bmim
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2?TO8fhtfty^4vmw*Bijftti>jn'rci ufUJPitmn
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approach)(evidence-based
Siviwwa uautitnk^mi(evidence-based information)
is\j\jfl«uuu iSafEEMCI
evidence-based information
expertjudgement
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evidence-based medicine 38l)'MaivmjWllwitf\J\JfWJUtlU ISafE uasmju EMCI Iwuri
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entnISafE aas EMCI
nsuuu ISafE ua« EMCI frrctta'rcnntwuirtrnj
ISafE tias EMCI 08l*l«1'J$ntiuwWJ
(social perspective)
cost-effectiveness analysis
(affordability)
(equity) ijnn
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/•»
am Bft8iiwii&wci,uuw& WLiU'HiiuBKLflfefbfiLniwutLurtttufissnjy.
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iuiytnvianuv-j<9n«cim)i
?s\ju\Jii«m4^snjj ^s
mvruwn
(effective list)
(pharmaceutical benefit scheme)
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en/
n.
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f l CJ ^ o/ i c. o / 9 /
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A.
B.
c.
D. wiJQ£iSfiii Vi1sI'3R'M'Mi3jtTOit<u<unj?a£Ji-3 i|15fu (absolute contraindication)
(contraindicated/serious/major drug interaction) Yl
E.
F.
m^
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iwwaA.
B.
A©
nT5^H£JTuanijqj?tnvisnii,vi-3 iP) luna'jj ACEI
enalapril (n)"
m^wl«8i«nuQnmy?£nvtahuwfln« lunau coxibsibuprofen (n)"
gastro protective agent IIJJQEJ tliu omeprazole (n)
W'Wnfi lunau coxibs WnuGI event
Health Technology Assessment (Chen
coxibs ym'U'UflMflami'vm 'wfieifi'u (QALY loss)
ibuprofen + generic omeprazole
'Jwanminfi Gl event
coxibs 5 excess risk
baseline risk(BNF ben) vtinypmui'i coxibs
prothrombotic agent S-aan^vhlwnfl myocardial
infarction Vila stroke
jj coxibs u
ezetimibe,rosuvastatin
lluri simvastatin (n) tmti/Vila atorvastatin (sto m§)
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(Department of Defense Pharmacoeconomic
Center. MTF Formulary Management for Antilipidemic I Drugs
(Statins and Adjuncts), bood)
gliptins
l$u,ri metformin (n) uas sulfonylurea wt! glipizide (n) Vila
repaglinide (-0 lu$lb{JVIlllS sulfonamides uai! a-glucosidase
inhibitors \mn acarbose (PI) lias pioglitazone (-3)
C©
H n n a TU n <3 n u ft oi s n ^ sj m i
wn
(pnstnoEn dacarbazine) uatMiaaimi
. I-] I
Imiri
reimbursable indication
foash^m rituximab tuwba diffuse large-B-cell
lymphoma)
Cki nuwmUTlUiij coxibs, saw palmetto extract, omega-en
capsule 8nvitnBffl«tn) IvTl-o
NSAIDs
coxibs vilaH GC-©-adrenergic antagonists
saw palmetto extract uasK statins vtla fibrates
omega-en capsule
C«n
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serratiopeptidase)
jJJ anti-inflammatory enzymes ( I "0
(wu acetylcysteine) In
Car
cinnarizine Lisa flunarizine flhunTvflSfi parkinsonism
cisapride on^flhunlviinw QT prolongation tiaaCi drug
interaction
fenoverine tlvinPl rhabdomyolysis
muscle relaxants t'rf'U orphenadrine
jfnvtfuyg^entjwnjj Beers Criteria boeilo
nimesulide tfniKlvflflfl fatal hepatotoxicity
short acting calcium channel blockers
nifedipine/diltiazem Wfl immediate release)
Iwuri
gatifloxacin
tegaserod
valdecoxib
rofecoxib
rosiglitazone
Cb
in Imiri
Vila cost-utility
cost-benefit Vila cost-effective
incremental cost
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ml/a!
effectiveness ratio (ICER) ehm'i © iviTua^ GDP
u @>teo,ooo tnvipia QALY gain
vila <ooo flaasn? eia QALY gain)
rmK bisphosphonatelufmita-an'Ufns^nyinsnnl™ osteoporosis(primary prevention)
QALY gain s>.mte aTUtnvi ua^
QALY gain vi ®.deo) uefutnvi
il^ultlisnil f
coxibs i^EJunn NSAIDS(ibuprofen Vila diclofenac
my? n.) win'n UfliW 'njJWQ QALY gain efaCi celecoxib (low
dose) £tirf,s:oo; celecoxib (high dose) £sxts),ooo; etoricoxib
£en©,Gnoo; meloxicam (low dose) £©o,moo; meloxicam (high
dose) £s)CT/,doo www.hta.acuk/fullmono/mongilsg)g).pdf ^<3
nei'mU'ii celecoxib nn etoricoxib fl'i ijmnajfliiflilwI'LW
etia-3^Rjja^nf)'w (fWTWtnwwwlflifHiwfrJTJj whvi £cno,ooo
eia Q ALY gain) iias«nsi€ jj'nAwin coxibs vi
• rmW PPI ueniJfyflEJnvJanuvl inw wu esomeprazole (loo
vila s:o mg) lumifntnlifl GERD •dI V
QALM (quality-adjusted life
month) ujawtiiimjnflumDu (s^s: m) vl^ PPIVia Hb receptor antagonist
PI a QALM gain (Spiegel BM. lso®o)
' QALY gain
ntu is
q (=il QALM gain O.OGT/S)
esomeprazole uiu sr ailpnv •Blt i thsi l f l GERD
to TU/
unvi (
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D.
snviei'n uw -atci w aii n-«a 3J\ tnl
(absolute contraindication)
(contra-
indicated/serious/major drug
interaction)
(absolute
contraindication)
n i uft fl vi n n VI -a Em
(contra-indicated/serious/
major drug inter-action) vunticva
(contraindicated) Vila
n n K s \ i i LI) u ati w-5 fil a) n vi fl w s 1 3 EJ
(serious) Vila
(major)
D® fovhuH fn lllu absolute contraindication
contraindication Vila precaution
relative
Dk>
Summary of Product Characteristics (5PC), US FDA official drug
labeling, Micromedex, Lexicomp, Clinical Pharmacology Vila
British National Formulary
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E.
voran
course "ya-afmintnvnnol'u
voriconazole
nu fl-anPiifinnTi liposomal
amphotericin B
®o ivin
E©voriconazole
liposomal amphotericin B
US eX tu
Em
(http://apps.who.int/medicinedocs/pdf/h6nos)sie/h mosKae.pdf)
F.
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