hyperbilirubinemia in infants christine piper, bsn, rn, cpn [email protected] alverno college msn...
TRANSCRIPT
![Page 1: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/1.jpg)
Hyperbilirubinemia in Infants
Christine Piper, BSN, RN, [email protected]
Alverno CollegeMSN 621May 2006
![Page 2: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/2.jpg)
Pick a topic to get started!
Introduction
Diagnosis
Pathophysiology
Treatment
Genetics
References
Risk Factors & Symptoms
Hyperbilirubinemia
Links
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How To Use This Tutorial• Each page will have action buttons that allow
the user to “go back” or to “move forward” found in the lower right hand corner
• There are action buttons on the main page that allow the user to navigate to main topics, reference pages, and other internet links that might be of interest
• To reach the main page after you are in a topic, there will be a home button located in the lower left hand corner that allows the user to go back to the main page
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How To Use This Tutorial
• Throughout this tutorial all italicized words are defined if you roll over the word with the mouse
• Please note there are sound effects throughout the presentation
![Page 5: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/5.jpg)
Purpose
• The purpose of this tutorial is to provide information regarding the pathophysiology, risk factors, symptoms, diagnosis, and current treatment recommendations regarding hyperbilirubinemia in infants
![Page 6: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/6.jpg)
Objectives
• To understand the pathophysiology of hyperbilirubinemia
• To identify risk factors for hyperbilirubinemia • To identify signs and symptoms of
hyperbilirubinemia• To understand diagnosing of hyperbilirubinemia in
infants• To understand current treatment recommendations
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What Is Hyperbilirubinemia?
• Hyperbilirubinemia (also known as jaundice) is an increased level of bilirubin in the blood
• It may occur due to physiologic factors that are seen as “normal” in the newborn
• It may be due to pathologic factors that alter the usual process in bilirubin metabolism (1)
![Page 8: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/8.jpg)
What Is Hyperbilirubinemia?
A. An increase in the amount of bilirubin in the blood
B. A decrease in the amount of bilirubin in the blood
C. There is no change in the amount of bilirubin in the blood
![Page 9: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/9.jpg)
Correct
Hyperbilirubinemia is an increase of bilirubin in the blood
![Page 10: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/10.jpg)
Incorrect
Try againIf you break the word apart
it helps you to define the word. For example
hyper = high, excessive
bilirubin = bilirubin
emia = blood
![Page 11: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/11.jpg)
Incorrect
Try againIf you break the word apart
it helps you define the word. For example
hyper = high, excessive
bilirubin = bilirubin
emia = blood
![Page 12: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/12.jpg)
What Is Bilirubin?• Bilirubin is the by product of the breakdown of
heme which is found in red blood cells (1)• Normal red blood cell destruction accounts for
80% of daily bilirubin produced in the newborn (10)
• Infants produce twice as much bilirubin per day than as an adult (1)
• There are two types of bilirubin - unconjugated (indirect) bilirubin and conjugated (direct) bilirubin
![Page 13: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/13.jpg)
Unconjugated Bilirubin
• Unconjugated (indirect) bilirubin– Fat-soluble– Not yet metabolized by by the liver– Is not easily excreted– Is the biggest concern for newborn jaundice– If it is not converted it can be deposited into
the skin which causes the yellowing of the skin or into the brain which can lead to kernicterus (1)
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Conjugated Bilirubin
• Conjugated (direct) bilirubin – Water soluble– It is metabolized by the liver– It is mostly excreted in stool and some in the
urine
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True or False
Unconjugated (indirect) bilirubin is bilirubin that is broken down by the liver and is excreted through the urine and stool
![Page 16: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/16.jpg)
Incorrect
Unconjugated (indirect) bilirubin is bilirubin that has not
yet been broken down by the liver
![Page 17: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/17.jpg)
Correct
Conjugated (direct) bilirubin is bilirubin that is broken down by the liver and is excreted in urine or stool
![Page 18: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/18.jpg)
Bilirubin Metabolism
Red blood cells are broken down in the Reticuloendothelial System (1)
Red blood cells break down to hemoglobin which is further broken down to iron, globin, and heme (1)
Iron
Globin
Heme
Biliverdin
Unconjugated bilirubin
HemoglobinRed blood cells
Liver
Conjugated bilirubin
Urobilinogen
Stercobilin
Reticuloendothelial System
Bilirubin albumin complex
![Page 19: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/19.jpg)
Bilirubin Metabolism
Iron
Globin
Heme
Biliverdin
Unconjugated bilirubin
HemoglobinRed blood cells
Liver
Conjugated bilirubin
Urobilinogen
Stercobilin
Reticuloendothelial System
Unconjugated bilirubin is then carried to the liver by albumin (1)
Heme is further broken down to biliverdin then to unconjugated bilirubin by the enzyme biliverdin reductase (1) Bilirubin albumin
complex
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Bilirubin Metabolism
Iron
Globin
Heme
Biliverdin
Unconjugated bilirubin
HemoglobinRed blood cells
Liver
Conjugated bilirubin
Urobilinogen
Stercobilin
Reticuloendothelial System
The liver then converts unconjugated bilirubin to conjugated bilirubin where it is excreted in the intestines (1)
The intestines then convert the conjugated bilirubin into urobilinogen and then stercobilin (1)
Bilirubin albumin complex
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Bilirubin Metabolism
Iron
Globin
Heme
Biliverdin
Unconjugated bilirubin
HemoglobinRed blood cells
Liver
Conjugated bilirubin
Urobilinogen
Stercobilin
Reticuloendothelial System
Urobilinogen is excreted in the urine (1)
Stercobilin is excreted in the stool (1)
Bilirubin albumin complex
![Page 22: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/22.jpg)
Click On The Correct Response To Complete The Diagram
Red blood cells are broken down to hemoglobin
Unconjugated bilirubin is carried to the liver by albumin
Urobilinogen is excreted in the urine
Stercobilin is excreted in the stool
Intestines convert conjugated bilirubin into urobilinogen and stercobilin
Liver converts unconjugated bilirubin to conjugated bilirubin where it is excreted in the intestines
Hemoglobin is further broken down to iron, globin, and heme
Heme is further broken down to bilverdin then to unconjugated bilirubin by the enzyme biliverdin reductase
![Page 23: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/23.jpg)
Click On The Correct Response To Complete The Diagram
Red blood cells are broken down to hemoglobin
Unconjugated bilirubin is carried to the liver by albumin
Urobilinogen is excreted in the urine
Stercobilin is excreted in the stool
Intestines convert conjugated bilirubin into urobilinogen and stercobilin
Liver converts unconjugated bilirubin to conjugated bilirubin where it is excreted in the intestines
Hemoglobin is further broken down to iron, globin, and heme
Heme is further broken down to bilverdin then to unconjugated bilirubin by the enzyme biliverdin reductase
![Page 24: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/24.jpg)
Click On The Correct Response To Complete The Diagram
Red blood cells are broken down to hemoglobin
Unconjugated bilirubin is carried to the liver by albumin
Urobilinogen is excreted in the urine
Stercobilin is excreted in the stool
Intestines convert conjugated bilirubin into urobilinogen and stercobilin
Liver converts unconjugated bilirubin to conjugated bilirubin where it is excreted in the intestines
Hemoglobin is further broken down to iron, globin, and heme
Heme is further broken down to bilverdin then to unconjugated bilirubin by the enzyme biliverdin reductase
![Page 25: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/25.jpg)
Click On The Correct Response To Complete The Diagram
Red blood cells are broken down to hemoglobin
Unconjugated bilirubin is carried to the liver by albumin
Urobilinogen is excreted in the urine
Stercobilin is excreted in the stool
Intestines convert conjugated bilirubin into urobilinogen and stercobilin
Liver converts unconjugated bilirubin to conjugated bilirubin where it is excreted in the intestines
Hemoglobin is further broken down to iron, globin, and heme
Heme is further broken down to bilverdin then to unconjugated bilirubin by the enzyme biliverdin reductase
![Page 26: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/26.jpg)
Click On The Correct Response To Complete The Diagram
Red blood cells are broken down to hemoglobin
Unconjugated bilirubin is carried to the liver by albumin
Urobilinogen is excreted in the urine
Stercobilin is excreted in the stool
Intestines convert conjugated bilirubin into urobilinogen and stercobilin
Liver converts unconjugated bilirubin to conjugated bilirubin where it is excreted in the intestines
Hemoglobin is further broken down to iron, globin, and heme
Heme is further broken down to bilverdin then to unconjugated bilirubin by the enzyme biliverdin reductase
![Page 27: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/27.jpg)
Click On The Correct Response To Complete The Diagram
Red blood cells are broken down to hemoglobin
Unconjugated bilirubin is carried to the liver by albumin
Urobilinogen is excreted in the urine
Stercobilin is excreted in the stool
Intestines convert conjugated bilirubin into urobilinogen and stercobilin
Liver converts unconjugated bilirubin to conjugated bilirubin where it is excreted in the intestines
Hemoglobin is further broken down to iron, globin, and heme
Heme is further broken down to bilverdin then to unconjugated bilirubin by the enzyme biliverdin reductase
![Page 28: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/28.jpg)
Click On The Correct Response To Complete The Diagram
Red blood cells are broken down to hemoglobin
Unconjugated bilirubin is carried to the liver by albumin
Urobilinogen is excreted in the urine
Stercobilin is excreted in the stool
Intestines convert conjugated bilirubin into urobilinogen and stercobilin
Liver converts unconjugated bilirubin to conjugated bilirubin where it is excreted in the intestines
Hemoglobin is further broken down to iron, globin, and heme
Heme is further broken down to bilverdin then to unconjugated bilirubin by the enzyme biliverdin reductase
![Page 29: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/29.jpg)
Click On The Correct Response To Complete The Diagram
Red blood cells are broken down to hemoglobin
Unconjugated bilirubin is carried to the liver by albumin
Urobilinogen is excreted in the urine
Stercobilin is excreted in the stool
Intestines convert conjugated bilirubin into urobilinogen and stercobilin
Liver converts unconjugated bilirubin to conjugated bilirubin where it is excreted in the intestines
Hemoglobin is further broken down to iron, globin, and heme
Heme is further broken down to bilverdin then to unconjugated bilirubin by the enzyme biliverdin reductase
![Page 30: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/30.jpg)
What Is Physiologic Jaundice?
• Physiologic jaundice is an exaggerated normal process seen in 60% of term infants, and 80% of premature infants (1)
• It normally occurs during the first week of life
• It is normally benign and self-limiting• Associated with a bilirubin level greater
than 5-7mg/dL (1)
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Factors That Contribute To Physiologic Jaundice
• Prematurity• Polycythemia
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Prematurity & Hyperbilirubinemia
• Premature infants are more susceptible to hyperbilirubinemia due to:
• Immature hepatic system
• Delayed enteral feedings
• Decrease in serum albumin levels
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Prematurity & Hyperbilirubinemia• Immature hepatic system - leads to decreased elimination of
bilirubin from the system; therefore, higher levels of indirect bilirubin are in the blood which leads to hyperbilirubinemia
Iron
Globin
Heme
Biliverdin
Unconjugated bilirubin
HemoglobinRed blood cells
Liver
Conjugated bilirubin
Urobilinogen
Stercobilin
Reticuloendothelial System
Bilirubin albumin complex
![Page 34: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/34.jpg)
Prematurity & Hyperbilirubinemia
• Delayed enteral feedings - if feedings are delayed it decreases intestinal motility and removal of meconium, which leads to reabsorption of direct bilirubin, which is converted back to indirect bilirubin. Which means bilirubin increases in the blood and leads to hyperbilirubinemia (10)
Iron
Globin
Heme
Biliverdin
Unconjugated bilirubin
HemoglobinRed blood cells
Liver
Conjugated bilirubin
Urobilinogen
Stercobilin
Reticuloendothelial System
Bilirubin albumin complex
![Page 35: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/35.jpg)
Prematurity & Hyperbilirubinemia• Decrease in serum albumin levels - if there is a decrease
in the amount of albumin receptors available, bilirubin does not bind to the albumin; therefore, is considered “free” bilirubin. Which means bilirubin increases in the blood and leads to hyperbilirubinemia (1)
Iron
Globin
Heme
Biliverdin
Unconjugated bilirubin
HemoglobinRed blood cells
Liver
Conjugated bilirubin
Urobilinogen
Stercobilin
Reticuloendothelial System
Bilirubin albumin complex
![Page 36: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/36.jpg)
Polycythemia & Hyperbilirubinemia
• Polycythemia is an increased level of red blood cells (RBCs) in the circulatory system
• A infant has more RBCs than an adult, and the lifespan of an RBC is shorter in neonates (1)
• Increased RBCs and a shorter lifespan leads to increased destruction of RBCs, which leads to more bilirubin in the blood, which leads to hyperbilirubinemia
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What percent of term infants have jaundice?
A. 80%
B. 50%
C. 60%
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Incorrect
Please try again
![Page 39: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/39.jpg)
Incorrect
Please try again
![Page 40: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/40.jpg)
Correct
60% of term infants have physiologic jaundice
![Page 41: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/41.jpg)
What Is Pathologic Jaundice?
• Pathologic jaundice is due to factors that alter the process of bilirubin metabolism
• It usually appears within 24 hours of life
• Associated with a bilirubin level increase of 0.5 mg/dL/ hour or 5mg/dL per day (10)
• Persists for longer than 7 to 10 days (10)
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Factors That Contribute To Pathologic Jaundice
• Hemolytic anemia • Rh incompatibility
• ABO incompatibility
• G6PD (glucose-6-phosphate deficiency) deficiency
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Hemolytic Anemia & Hyperbilirubinemia
• Hemolytic anemia is an incompatibility between the blood of the mother and her fetus
• This can occur due to Rh incompatibility or ABO blood incompatibility
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Rh Incompatibility
• Rh incompatibility is when the mother lacks the Rh factor on the surface of her red blood cells and her baby is born with the Rh factor on his or her red blood cells (13)
• This occurs in about 15% of the Caucasian population and 7% of the African American population (13)
• It does not occur with the first born child
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Rh Incompatibility
• In Rh incompatibility there is potential for the infant’s blood to enter the mother’s system (13)
• If this happens the mother will develop antibodies against the fetal blood cells which may cross the placenta and destroy the infant’s red blood cells (13)
• Increased destruction of red blood cells leads to increased bilirubin in the blood; therefore, leading to hyperbilirubinemia
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Treatment for Rh Incompatibility
• There is an injection called Rh immune globulin (also known as Rhogam) which is given to pregnant women at 28 weeks of pregnancy and within 72 hours of delivering an infant who is born Rh positive (13)
• This injection prevents the mother’s body from forming antibodies against the Rh factor found on fetal red blood cells (13)
• If the mother is already sensitized, meaning her body has already made antibodies against the Rh factor, the injection will be ineffective (13)
• This injection prevents sensitization in more than 95% of Rh negative women (13)
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ABO Blood Incompatibility
• ABO incompatibility occurs with any blood type; however, it is more common if the mother has type O blood and the infant has blood type A, B, or AB
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ABO Blood Incompatibility
• Fetal cells cross the placenta and enter the mother’s bloodstream (6)
• When this occurs the mother’s body forms antibodies against the fetal cells (6)
• Those antibodies are then small enough to cross back through the placenta into the baby’s circulation and cause destruction of red blood cells (6)
• Increased destruction of red blood cells leads to increased bilirubin in the blood; therefore, leading to hyperbilirubinemia
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Glucose-6-Phosphate Dehydrogenase G6PD
• The function of G6PD enzyme is to initiate an oxidation/reduction reaction (3)
• An oxidation/reduction reaction is transferring electrons from one molecule to the next (3)
• Oxidation is the loss of electrons and reduction is the gain of electrons (3)
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G6PD
The G6PD enzyme is responsible for reducing NADP+(nicotinamide adenine dinucleotide phosphate) to NADPH (reduced nicotinamide adenine dinucleotide phosphate) (3)
Retrieved from http://www.malariasite.com/malaria/g6pd.htm
Used with permission (11)
Pentose Phosphate Pathway
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G6PD• Without adequate levels of NADPH, red blood
cells are more prone to stress and oxidation, which leads to hemolysis of red blood cells (3)
• If there is a G6PD deficiency there will not be adequate levels of NADPH; therefore, leading to increased hemolysis of red blood cells
• Increased hemolysis of red blood cells leads to increased levels of bilirubin, which then leads to hyperbilirubinemia
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Physiologic
Occurs 24 hours after birth
Prematurity
Polycythemia
Pathologic
Occurs less than 24 hours after birth
Hemolytic anemia
G6PD deficiency
Physiologic Jaundiceversus
Pathologic Jaundice
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Identify The Causes Of Pathologic Jaundice
Hemolytic anemia
ABO incompatibility
Increased fluid intake
G6PD deficiency
Prematurity
Polycythemia
Rh incompatibility
Headache
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Kernicterus
• Kernicterus is a rare, irreversible complication of hyperbilirubinemia
• If bilirubin levels become markedly elevated, the unconjugated bilirubin may cross into the blood brain barrier and stain the brain tissues (1)
• If staining of the brain tissues occurs there is permanent injury sustained to areas of the brain which leads to neurological damage (10)
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Kernicterus
• “Kernicterus is used to describe the yellow staining of the brain nuclei as seen on autopsy (kern means nuclear region of the brain; icterus means jaundice)” (Juretschke, 2005, p. 10)
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Picture Of A Brain With Kernicterus
Yellow staining in the brain due to
increased unconjugated
bilirubin passing through the
blood brain barrier
Retrieved April 30, 2006, from
http://www.urmc.rochester.edu/neuroslides/slide156.html
Used with permission (9)
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Kernicterus
• Early signs of kernicterus are: lethargy, poor feeding, temperature instability, and hypotonia (1)
• Symptoms then progress to: hypertonia, opisthotonos and arching, fever, seizures, and high pitched cry (10)
• Long term effects are: choreoathetoid cerebral palsy, tremerousness, mental retardation, sensorineural hearing loss, dental dysplasia, and upward gaze paresis (10)
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True or False
Genetics play a part in hyperbilirubinemia
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Correct
There are studies that link genetic mutations in enzymes to increased risk
for hyperbilirubinemia
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Incorrect
There are studies that link genetic mutations in enzymes to increased risk
for hyperbilirubinemia
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Genetics & Hyperbilirubinemia
• A study done from 2001 to 2003 looked at three enzymes with possible genetic defects that were linked to increased rates of hyperbilirubinemia in the Asian population (7)
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Genetics & Hyperbilirubinemia
• The study was conducted in Taiwan• The reason for this is because the Asian
population has twice the incidence of hyperbilirubinemia than the Caucasian population (7)
• They were looking to identify potential genetic defects that contribute to the higher incidence of hyperbilirubinemia
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Genetics & Hyperbilirubinemia
The three enzymes are: • G6PD - glucose-6-phosphate
dehydrogenase• OTAP 2 - organic anion
transporter 2• UGT1A1 - UDP-
glucuronsyltransferase 1A1
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G6PD
The G6PD enzyme is responsible for reducing NADP+(nicotinamide adenine dinucleotide phosphate) to NADPH (reduced nicotinamide adenine dinucleotide phosphate) (3)
Retrieved from http://www.malariasite.com/malaria/g6pd.htm
Used with permission (11)
Pentose Phosphate Pathway
![Page 65: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/65.jpg)
Glucose-6-Phosphate Dehydrogenase G6PD
• The function of G6PD enzyme is to initiate an oxidation/reduction reaction (3)
• An oxidation/reduction is transferring electrons from one molecule to the next (3)
• Oxidation is the loss of electrons and reduction is the gain of electrons (3)
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G6PD• G6PD is also responsible for maintaining adequate
levels of NADPH inside the cells (3)• If there is a G6PD deficiency there will not be
adequate levels of NADPH• Without adequate levels on NADPH, red blood cells
are more prone to stress and oxidation, which leads to hemolysis of red blood cells (3)
• If there is increased hemolysis of red blood cells, there will be increased levels of bilirubin, which then leads to hyperbilirubinemia
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G6PD enzyme
Retrieved April 8, 2006, from http://www.rcsb.org/pdb/explore.do?structureId=1QKI
Used with permission
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Organic Anion Transporter 2 OATP 2
• The function of the OATP 2 enzyme is involved in the hepatic uptake of unconjugated bilirubin (7)
Iron
Globin
Heme
Biliverdin
Unconjugated bilirubin
HemoglobinRed blood cells
Liver
Conjugated bilirubin
Urobilinogen
Stercobilin
Reticuloendothelial System
Bilirubin albumin complex
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Organic Anion Transporter 2 OATP 2
• In the study done, the authors identified polymorphisms in the OATP 2 enzyme, which led to increased risk for hyperbilirubinemia in the Asian population (7)
• If the enzyme activity is delayed there will be increased levels of unconjugated bilirubin in the blood, therefore leading to hyperbilirubinemia
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UDP - Glucuronsyltransferase 1A1
UGT1A1• The function of UGT1A1 is to convert
unconjugated or indirect bilirubin to conjugated or direct bilirubin (7)
Iron
Globin
Heme
Biliverdin
Unconjugated bilirubin
HemoglobinRed blood cells
Liver
Conjugated bilirubin
Urobilinogen
Stercobilin
Reticuloendothelial System
Bilirubin albumin complex
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UDP - Glucuronsyltransferase 1A1 UGT1A1
• In the study done, the authors identified polymorphisms in the UGT1A1 enzyme which, led to increased risk for hyperbilirubinemia in the Asian population (7)
• If the enzyme activity is delayed there will be increased bilirubin in the blood, therefore leading to hyperbilirubinemia
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What enzyme is responsible for converting unconjugated (indirect) bilirubin to conjugated (direct) bilirubin?
A. G6PD
B. UGT1A1
C. OATP 2
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Correct
The UGT1A1 is responsible for converting unconjugated (indirect)
bilirubin to conjugated (direct) bilirubin
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IncorrectPlease try again!
The G6PD enzyme is responsible for
maintaining adequate levels of NADPH in the red blood cells
which helps prevent hemolysis of red
blood cells
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Incorrect
Please try again!
The OATP 2 enzyme is involved in the
hepatic uptake of unconjugated
bilirubin
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What enzyme is responsible for maintaining adequate levels of NADPH in the red blood cells which helps prevent hemolysis of red blood cells?
A. G6PD
B. OATP 2
C. UGT1A1
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Correct
The G6PD enzyme is responsible for maintaining adequate levels of NADPH in the red blood cells which helps prevent hemolysis of
red blood cells
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Incorrect
Please try again!
The OATP 2 enzyme is involved in the
hepatic uptake of unconjugated
bilirubin
![Page 79: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/79.jpg)
Incorrect
Please try again!
The UGT1A1 is responsible for
converting unconjugated
(indirect) bilirubin to conjugated (direct)
bilirubin
![Page 80: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/80.jpg)
What enzyme is involved in the hepatic uptake of unconjugated bilirubin?
A. G6PD
B. OATP 2
C. UGT1A1
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Correct
The OATP 2 enzyme is involved in the hepatic uptake of unconjugated
bilirubin
![Page 82: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/82.jpg)
Incorrect
Please try again!
The G6PD enzyme is responsible for
maintaining adequate levels of NADPH in the red blood cells which
helps prevent hemolysis of red
blood cells
![Page 83: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/83.jpg)
Incorrect
Please try again!
The UGT1A1 is responsible for
converting unconjugated
(indirect) bilirubin to conjugated (direct)
bilirubin
![Page 84: Hyperbilirubinemia in Infants Christine Piper, BSN, RN, CPN cpiper79@wi.rr.com Alverno College MSN 621 May 2006](https://reader035.vdocuments.mx/reader035/viewer/2022062516/56649e235503460f94b0fff4/html5/thumbnails/84.jpg)
Major Risk Factors for Hyperbilirubinemia in Full-Term
Newborns • Jaundice within first 24 hours after birth
• A sibling who was jaundiced as a neonate
• Unrecognized hemolysis such as ABO blood type incompatibility or Rh incompatibility
• Nonoptimal sucking/nursing
• Deficiency in glucose-6-phosphate dehydrogenase, a genetic disorder
• Infection
• Cephalohematomas /bruising
• East Asian or Mediterranean descent
Retrieved April 18, 2006, from http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5023a4.htm
Used with permission (2)
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Signs & Symptoms
• Poor feeding
• Increased sleepiness
• Increased yellowing of the skin or sclera
• Increased bilirubin level
• Hypotonia
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Diagnosis
•Check bilirubin level
•Check complete blood count
•Check reticulocyte count
•Coombs test
•Blood groups & types
•G6PD level
•Albumin level
•Visual assessment (least reliable)
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Bilirubin Level
• This test is to measure the amount of bilirubin in the blood
• Increased bilirubin = hyperbilirubinemia
• In term infants a normal bilirubin level is between 1.0 - 10.0 mg/dL (4)
• There is NO safe bilirubin level identified
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Complete Blood Count
• This test will determine if the infant has increased red blood cells in the circulatory system (polycythemia)
• If an infant has a hematocrit greater than 65% this places that infant at risk for hyperbilirubinemia (16)
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Reticulocyte Count• This test measures young non-nucleated
red blood cells (4)
• If the reticulocyte count is greater than 5% in the first week of life, this identifies the infant as trying to replace destroyed red blood cells (16)
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Blood Groups & Types
• ABO grouping and Rh types are confirmed by examining RBCs for presence of blood group antigens and RBCs and antibodies against these antigens (4)
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Direct Coombs Test
Retrieved April 18, 2006, from
http://en.wikipedia.org/wiki/Image:Coombs_test_schematic.png
Used with Permission (15)
• “The direct coombs test is a direct measure of the amount of maternal antibody coating the infant’s red blood cell” (Blackburn, 1995, p. 21)
• If the antibody is present, the test is positive
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Indirect Coombs Test
• “The indirect coombs test measures the effect of a sample of the infant’s serum (which is thought to contain maternal antibodies) on unrelated adult RBCs” (Blackburn, 1995, p. 21)
• “If the infant’s serum contains antibodies, they will interact with and coat these adult RBCs (positive test)” (Blackburn, 1995, p. 21)
Retrieved April 18, 2006, from
http://en.wikipedia.org/wiki/Image:Coombs_test_schematic.png
Used with Permission (15)
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G6PD Level
• The G6PD level is done to identify neonates at risk for G6PD deficiency
• “The Beutler fluorescent spot test is a rapid and inexpensive test that visually identifies NADPH produced by G6PD under ultraviolet light. When the blood spot does not fluoresce, the test is positive; it can be false-positive in patients who are actively hemolysing. It can therefore only be done several weeks after a hemolytic episode” (Glucose-6-phosphate-dehydrogenase deficiency, n.d., ¶ 16)
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Albumin Level
• This test indicates the reserve amount of serum albumin available for binding indirect bilirubin (16)
• A normal albumin level in a term infant is between 2.6 - 3.6 g/dL (4)
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Visual Assessment
• “Visual assessment of jaundice is most accurate when the infant’s skin is blanched with light digital pressure in a well-lit room” (Juretschke, 2005, p. 11)
• “As bilirubin levels rise, the accuracy of visual assessment decreases” (Juretschke, 2005, p. 11)
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Zones Showing Kramer’s Progression Of Jaundice
• Jaundice proceeds in a cephalopedal progression, meaning jaundice progresses from the head down to the toes (10)
• This diagram demonstrates what level the bilirubin is at depending on what areas of the infant’s body is jaundiced
• For example, if the infant was noted to be jaundiced from the head to the neck that would be zone 1 and the bilirubin level would be between 4 – 8 mg/dL
After Kramer, 1969 (12)
Zone 1 2 3 4 5
Bilirubin 4-8 5-12 8-16 11-18 >15
Level (mg/dL)
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Treatment
• Phototherapy is treatment of choice
• Encourage frequent feedings
• Intravenous hydration
• Intravenous immune globulin
• Exchange transfusion
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Phototherapy
• “In the mid-1950s, Sister Jean at Rochford General Hospital in England noted that infants exposed to sunlight were less jaundiced in the uncovered skin areas than their nonexposed counterparts” (17)
• Phototherapy works by converting indirect bilirubin to lumirubin, a water-soluble compound that is a more excretable form of bilirubin (10)
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Phototherapy• “Only certain wavelengths (colors) of light are
absorbed by bilirubin; as bilirubin is a yellow pigment, blue is absorbed more effectively, however, green light is more deeply absorbed into the skin” (17)
Retrieved April 24, 2006, fromhttp://en.wikipedia.org/wiki/Image:Infant_jaundice_treatment.jpg
Used with permission
An infant undergoing
phototherapy
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Frequent Feedings
• Encouraging frequent feedings at least eight times per day helps to stimulate intestinal motility and removal of meconium, thus reducing reabsorption of direct bilirubin into the system (1)
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Intravenous Hydration
• Intravenous hydration of infants with hyperbilirubinemia was thought to decrease bilirubin levels, however, unless an infant is dehydrated intravenous hydration is not indicated (17)
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Intravenous Immune Globulin
• Intravenous immune globulin (IVIG) has been used to decrease bilirubin levels due to hemolytic anemia
• It is thought that IVIG interferes with receptors in the reticulendothelium that are necessary for hemolysis to occur (10)
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Exchange Transfusion
• An exchange transfusion is used only in extreme cases when phototherapy has failed
• The process for an exchange transfusion involves small amounts of blood being removed from the infant and then replaced with the same amount of donor RBCs and plasma (1)
• The process continues until twice the circulating volume has been replaced (1)
• The exchange replaces ~ 87% of the circulating blood volume and decreases the bilirubin level by ~ 55% (1)
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Links• For information on kernicterus there is a
website entitled Parents of Infants and children with Kernicterus. Their website is http://www.pickonline.org/
• A Sentinel Alert was issued in April 2001 by the Joint Commission on Accreditation of Healthcare Organizations on Kernicterus. The website address is http://www.jointcommission.org/SentinelEvents/SentinelEventAlert/sea_18.htm
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References1. Blackburn, S. (1995). Hyperbilirubinemia and neonatal jaundice.
Neonatal Network, 14(7), 15-29.
2. Center for Disease Control and Prevention. (2001). Kernicterus in full-term infants-United States, 1994-1998. Morbidity and Mortality Weekly Report, 50(23), p. 494. Retrieved April 18, 2006, from
http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5023a4.htm
3. Ethnasios, R. (2003). Physiology of G6PD. Retrieved March 2, 2006, from http://www.rialto.com/g6pd/physiolo.htm
4. Fischbach, F. Nurses’ quick reference to common laboratory and diagnostic tests (2nd ed.). Philadelphia: Lippincott-Raven.
5. Glucose-6-phosphate dehydrogenase deficiency. (n.d.). Wikipedia. Retrieved May 1, 2006, from Answers.com Web site: http://www.answers.com/topic/glucose-6-phosphate-dehydrogenase-deficiency
6. Hull, J. (2006). ABO incompatibility. Retrieved March 31, 2006, from http://www.drhull.com/EncyMaster/A/ABO_incompatibility.html
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References7. Huang, M., Kua, K., Teng, H., Tang, K., Weng, H., & Huang, C.
(2004). Risk factors for severe hyperbilirubinemia in neonates. Pediatric Research, 56(5), 682-89.
8. Infant undergoing home phototherapy for jaundice. (2005). Retrieved April 25, 2006, from http://en.wikipedia.org/wiki/Image:Infant_jaundice_treatment.jpg
9. Józefowicz, R., Miller, J., & Powers, J. (2000). Neuropathy and neuroimaging laboratory: Mind, brain, and behavior course. University of Rochester School of Medicine and Dentistry. Retrieved April 30, 2006 from http://www.urmc.rochester.edu/neuroslides/slide156.html
10. Juretschke, L. (2005). Kernicterus: Still a concern. Neonatal Network, 24(2), 7-19.
11. Kakkilaya, B., M.D. (2005). Glucose 6 phosphate dehydrogenase deficiency. Retrieved March 18, 2006, from http://www.malariasite.com/malaria/g6pd.htm
12. Kramer, L. (1969). Advancement of dermal icterus in the jaundiced newborn. American Journal of Diseases of Children, 118(3), 454-458. Copyright © (1969), American Medical Association, All Rights Reserved.
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References13. March of Dimes Birth Defects Foundation. (2001). Quick reference
and fact sheets: Rh disease. Retrieved February 28, 2006, from
http://www.marchofdimes.com/printableArticles/681_1220.asp?printable=true
14. PDB ID: 1QKI (Identification of the enzyme in the database)Au, S.W.N., Gover, S., Lam, V.M.S., & Adams, M.J. Human Glucose-6-Phosphate Dehydrogenase: The Crystal Structure Reveals a Structural Nadp+ Molecule and Provides Insights Into Enzyme Deficiency.Stucture v8 pp. 293 (2000).Retrieved April 8, 2006, from http://www.rcsb.org/pdb/explore.do?structureId=1QKI
15. Rad, A. (2006). Coombs test. Retrieved May 1, 2006, from http://en.wikipedia.org/wiki/Coombs_test
16. Schwobel, A. & Sakraida, S. (1997). Hyperbilirubinemia: new approaches to an old problem. Journal of Perinatal & Neonatal Nursing, 11(3), 78-98.
17. Steffensrud, S. (2004). Hyperbilirubinemia in term and near term infants: Kernicterus on the rise? Newborn and Infant Nursing Reviews, 4(4), 191-200.
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References18. Venes, D. (Ed.). (2005). Taber’s cyclopedic medical dictionary
(20th ed.), Philadelphia: F.A. Davis Company.
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The End!• Thank you for taking the time to complete
this tutorial on neonatal jaundice
• If there are any questions, please contact me at [email protected]