human memory declarative (explicit) nondeclarative (implicit) facts events procedural (skills and...
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Cellular Basis of Learning and MemoryBIPN 148
Spring 2007April 2-June 8, 2007
This course will examine the cellular and molecular mechanisms that underlielearning and memory. Top ics covered will include the role of the hippocampus inlearning and memory, neurotransmitter systems and receptors involved inlearning and memory, and biochemical mechanisms of synaptic plasticity.Emphasis will be placed on discussing experiments from the primary literature. Asolid background in cell and molecular biology is expected.
Prerequisites: BILD 1; BILD 2; BIBC 100/102; BIPN140 highly recommended.
Times: MWF at 3:00Location: CSB2Web Site: http://www.biology.ucsd.edu/classes/bipn148.SP07/
Recommended Text Ghosh and Scanziani 2007 Lecture NotesLecture notes are available for purchase through University Readers athttp://www.universityreaders.com/students
Grading: Weekly Quizzes: 40%Group paper: 20%Group presentation: 10%Final Exam: 30%Grading is on a curve.
Discussion Sessions/TA office hours (optional)Monday, 10-11 (Lara Pickle and Lauren Hollingsworth)Thursday, 4-5 (Dan Keller, 111 5 Pacific Hall)
CONTACT INFORMATION
PROFESSORSAnirvan Ghosh, Pacific Hall 1123, [email protected], 822 4142.Massimo Scanziani, CMG 2nd Floor, [email protected], 822 3839
TEACHING ASSISTANTSDan Keller, [email protected] Pickle, [email protected] Hollingsworth, [email protected]
Office Hours for Professors by appointment
HUMAN MEMORY
DECLARATIVE(EXPLICIT)
NONDECLARATIVE(IMPLICIT)
FACTS EVENTS
PROCEDURAL (SKILLS AND
HABITS)
PRIMING SIMPLE CLASSICAL
CONDITIONING
NONASSOCIATIVELEARNING
EMOTIONAL RESPONSES
SKELETAL MUSCULATURE
MEDIAL TEMPORAL
LOBE
STRIATUM NEOCORTEX AMYGDALA CEREBELLUM REFLEXPATHWAYS
Subdivisions of Human Memory
Milner B, Squire LR, Kandel ER: "Cognitive neuroscience and the study of memory". Neuron 1998, 20:445-468.
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Ivan Pavlov
Classical Conditioning(an example of implicit memory)
Implicit Memory: Pavlovian Associative Conditioning
Conditioned Stimulus
UnconditionedStimulus
Conditioned Stimulus
UnconditionedResponse
ConditionedResponse
TRAINING
CONTEXTUAL TEST CUED TEST
•Animal is placed in novel context•Hears a tone•Receives foot shock
•Animal is returned to same context•Test for freezing behavior
•Animal is placed in modified context•Hears a tone•Test for freezing behavior
Implicit Memory: Fear Conditioning
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Implicit memory: Conditioned Taste Aversion
DAY 1
DAY 2
1st Exposure to Food Item
2nd Exposure to Food Item
Injection of LiCl or NaCl
Grams Ingested on 2nd Exposure(LiCl treated group compared to NaCl treated
control)
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Implicit Memory: Neophobia
DAY 1
DAY 2
1st Exposure to Food Item
A
Grams Ingested(1st exposure compared to second exposure)
B
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2nd Exposure to Food Item
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Hermann Ebbinghaus(Distinction between short-term
and long term memory)
Sensory Information
Working Memory/Short term Memory(Minutes)
Long Term Memory(Hours/Days/Years)
By testing subjects after various delays Ebbinghaus developed the concept of short-term and long term memory