By: Brian

-Hemophilia is a bleeding disorder that slows down the blood clotting process. People who have Hemophilia often have longer bleeding after some sort of contact to injury. People who have severe Hemophilia start to have spontaneous bleeding in the joints and muscles all around your body. Hemophilia is more common in males than females.

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Types of HemophiliaHemophilia A:

Also known as classic hemophilia or Factor VIII DeficiencyPeople with this type of hemophilia have low levels of a blood clotting factor called figure 8 (FVIII)

Hemophilia B:Also known as Christmas disease or Factor IX DeficiencyPeople with this type of hemophilia have low levels of a blood clotting factor called figure 9 (FIX)

-The two different types of hemophilia are caused by permanent gene changes (mutations). Mutations in the FVIII gene cause Hemophilia A. Mutations in the FIX gene cause Hemophilia B.

Hemophilia A:Also known as classic hemophiliaPeople with this type of hemophilia have low levels of a blood clotting factor called figure 8 (FVIII)

-Severe Hemophilia A: Spontaneous joint or deep muscle bleeding. Usually diagnosed within first two years of life.-Moderate Hemophilia A: spontaneous bleeding, delayed oozing after minor injury, and usually diagnosed before they are 5 to 6 years old. - Mild Hemophilia A: Do NOT have spontaneous bleeding but unusual bleeding occurs with surgery and tooth extractions. People are usually diagnosed with this in later life.

Hemophilia A

Hemophilia B:Also known as Christmas diseasePeople with this type of hemophilia have low levels of a blood clotting factor called figure 9 (FIX)

-Severe Hemophilia B: Spontaneous joint or deep muscle bleeding is the most frequent symptom. People are usually diagnosed in the first 2 years of life.-Moderate Hemophilia B: spontaneous bleeding, delayed oozing after minor injury, and usually diagnosed before they are 5 to 6 years old- Mild Hemophilia B: Do NOT have spontaneous bleeding but unusual bleeding occurs with surgery and tooth extractions. People are usually diagnosed with this in later life.

The two different types of hemophilia are caused by permanent gene changes (mutations). Mutations in the FVIII gene cause Hemophilia A. Mutations in the FIX gene cause Hemophilia B.

Which type is more common?Hemophilia A is more common than Hemophilia B. One in 5000-10000 males around the world have Hemophilia A. One in 20,000- 34,500 males around the world have Hemophilia B.

Symptoms Of HemophiliaPerpetuated oozing after injuriesrepeated bleeding after first bleedingEasy or spontaneous bruisingPerpetuated bleeding

- The most frequent symptom for Hemophilia’s types A&B is spontaneous joint bleeding.

How is Hemophilia diagnosed?Hemophilia A&B are diagnosed by measuring factor clotting activity. Individuals who have Hemophilia A have low factor VIII clotting activity. Individuals who have hemophilia B have low factor IX clotting activity. Genetic testing is also available for the factor VIII gene and the factor IX gene. Genetic testing of the FVIII gene finds a disease-causing mutation in up to 98 percent of individuals who have hemophilia A. Genetic testing of the FIX gene finds disease-causing mutations in more than 99 percent of individuals who have hemophilia B. Genetic testing is usually used to identify women who are carriers of a type FVIII or FIX gene mutation, and to diagnose hemophilia in a fetus during a pregnancy. It is sometimes used to diagnose individuals who have mild symptoms of hemophilia A or B.

Hemophilia A and hemophilia B are inherited in an X-linked recessive pattern. The genes associated with these conditions are located on the X chromosome, which is one of the two sex chromosomes. In males (who have only one X chromosome), one changed copy of the gene in each cell is sufficient to cause the condition. In females (who have two X chromosomes), a mutation would have to occur in both copies of the gene to cause the disorder. Because it is unlikely that females will have two changed copies of this gene, it is very rare for females to have hemophilia. A characteristic of X-linked inheritance is that fathers cannot pass X-linked traits to their sons. In X-linked recessive inheritance, a female with one changed copy of the gene in each cell is called a carrier. Carrier females have about half the usual amount of clotting factor VIII or clotting factor IX, which is generally enough for normal blood clotting. However, about 10 percent of carrier females have less than half the normal amount of one of these clotting factors; these individuals are at risk for unusual bleeding, particularly after an injury, surgery, or tooth extraction.

Is Hemophilia inherited?

Right now, there is no cure for Hemophilia but, there are some treatments being used depending on the` severity of hemophilia

Is there a cure for Hemophilia?

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