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©2020 Baxter Healthcare Corporation 1 Helping Empower Recovery The Online Series (Heros) PART 5: 90 Days Post Covid-19 – How Care Has Changed in the ICU June 5, 2020 1 GLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation Support for this program is provided by Baxter International Inc. This program is not an accredited continuing education (CE) program Today’s presentation slides and on-demand viewing of this program will be available by 12-June at: https://www.baxterglobal.com/nutrition_hero_series Program Disclosure 2 GLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation 1 2

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  • ©2020 Baxter Healthcare Corporation

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    Helping Empower Recovery

    The Online Series (Heros)PART 5:

    90 Days Post Covid-19 –How Care Has Changed in the ICU

    June 5, 2020

    1GLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    • Support for this program is provided by Baxter International Inc.

    • This program is not an accredited continuing education (CE) program

    • Today’s presentation slides and on-demand viewing of this program will be available by 12-June at:

    https://www.baxterglobal.com/nutrition_hero_series

    Program Disclosure

    2GLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

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    Faculty

    Elisabeth De Waele, MD, PhD

    Medical Director

    Head of Clinical Nutrition

    Critical Care Physician and Surgeon

    Universitair Ziekenhuis Brussel

    Brussels, Belgium

    3GLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    Disclosures

    Elisabeth De Waele, MD, PhD

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    Unrestricted Grants/Research Funding by:

    Belgian Federal

    Government Health

    Baxter

    Nutricia

    KCE (Belgian Health Care

    Knowledge Centre)

    Fresenius

    Nestlé

    GLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

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    • Address the nutritional requirements of COVID-19 patients

    • Discuss the role of delivery and monitoring of nutrition support in the COVID-19 ICU patient

    • Review of best practices experienced in treating COVID-19 patients

    Objectives

    5GLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    FIRST 90 DAYS POST COVID-19:

    HOW HAS CARE CHANGED IN THE ICU

    Elisabeth De Waele, MD PhD

    ICU – Nutrition Department

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    IGLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    NOW IS THE TIME TO STAND STILL AND LOOK AROUND

    Corona in Belgium

    Coronaviruscovid19.be

    Known infections Deceased

    …left the

    hospital

    …in the

    hospital

    …deceased in and

    outside hospital

    …in ICU

    2020

    Number of

    patients…

    MAR APR MAY

    7

    Belgian Government website, accessed 06/01/20

    www.coronaviruscovid19.be

    IGLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    NOW IS THE TIME TO STAND STILL AND LOOK AROUND

    Total Number Of Cases Deaths Healed

    Admitted Versus Discharged Patients In ICUAdmitted Patients In Hospital

    8Belgian Government website, accessed June 2020

    www.coronaviruscovid19.be

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    IGLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    UNIVERSITY HOSPITAL BRUSSELS – MY WORLD

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    OUTCOME OF COVID19 PATIENTS UZ BRUSSELS

    79% of all COVID19 patients

    admitted in UZ Brussel

    are home

    6% are still in the ward

    15% died

    10GLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    Quality data ICU IZBrussels, shared with permission

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    IGLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    BELGIAN OUTCOME DATA

    healed

    49%

    died

    23%

    on the

    ward

    15%

    still in

    ICU

    11%

    other hospit 2%

    ICU Patients

    healed

    27%

    died

    28%

    on the

    ward

    21%

    still in

    ICU

    21%

    other hospit 3%

    Ventilated ICU Patients

    healed

    77%

    died

    11%

    on the

    ward

    10%

    other

    hospit

    2%

    Non ICU Patients

    77% of patients

    admitted to ICU

    survived

    72% of ventilated ICU

    patients survived

    89% of ward

    patients survived

    764 278 2.969

    11de standaard June 2020

    IGLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    healed

    50%

    died

    50%

    ICU Patients

    CORONAVIRUS: NEW FIGURES ON INTENSIVE CARE

    DEATHS REVEALED

    healed

    49%

    died

    23%

    on the

    ward

    15%

    still in

    ICU

    11%

    other hospit 2%

    ICU Patients

    77% of patients

    admitted to ICU

    survived

    764

    50% of ventilated ICU

    patients survived

    12The Guardian March 28, 2020

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    IGLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    healed

    27%

    died

    28%

    on the

    ward

    21%

    still in

    ICU

    21%

    other hospit 3%

    Ventilated ICU Patients

    healed 3%

    died

    97%

    Ventilated ICU Patients

    CLINICAL COURSE AND RISK FACTORS FOR MORTALITY OF ADULT INPATIENTS

    WITH COVID19 IN WUHAN, CHINA: A RETROSPECTIVE COHORT STUDY

    191

    72% of ventilated ICU

    patients survived

    278

    3% of ventilated ICU

    patients survived

    Fei Zhou, MD; Ting Yu, MD; Ronghui Du, MD; Guohui Fan, MS; Ying Liu, MD; Zhibo Liu, MD; Jie Xiang, MS; Yeming Wang, MD; Bin Song, MS; Xiaoying Gu, PhD; Lulu Guan, MD;

    Yuan Wei, M; Hui Li, MD; Xudong Wu, MS; Jiuyang Xu, MD; Shengjin Tu, MD; Yi Zhang, MD; Prof Hua Chen, MD; Prof Bin Cao, MD

    13Zhou Lancet March 9, 2020

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    https://crossmark.crossref.org/dialog?doi=10.1016/S0140-6736(20)30566-3&domain=www.thelancet.com&uri_scheme=https:&cm_version=v2.0

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    IGLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    INTENSIVE CARE MANAGEMENT OF CORONAVIRUS DISEASE

    2019 (COVID-19): CHALLENGES AND RECOMMENDATIONSJason Phua, MRCP; Li Weng, MD; Lowell Ling, MRCP; Moritoki Egi, MD; Prof Chae-Man Lim, MD; Prof Jigeeshu Vasishtha Divatia, MD; Prof Babu Raja Shrestha, MD; Prof Yaseen M Arabi, MD;

    Jensen Ng, M Med Anaesthesiology; Prof Charles D Gomersall, FCICM; Prof Masaji Nishimura, MD; Prof Younsuck Koh, MD; Prof Bin Du, MD for the Asian Critical Care Clinical Trials Group

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    https://crossmark.crossref.org/dialog?doi=10.1016/S2213-2600(20)30161-2&domain=www.thelancet.com&uri_scheme=https:&cm_version=v2.0

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    I 17GLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation Barazzoni Clin Nutr March 2020

    IGLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    15 MARCH 2020 FIRST PATIENTS

    We Developed Our Plan March 12th

    – Almost No Guidance Around

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    STRUCTURED INTERVENTIONS – BOTTOM-UP INITIATIVES

    Macro levelOperational

    management

    Communication

    and staff

    well being

    Non-ICU

    environment

    (Coronary

    Care Unit,

    recovery room)

    Internal and

    external

    stakeholders

    contact

    Medical and

    organizational

    command

    Communication

    strategies

    Staff physical and

    psychological well-

    being

    Patient’s Family

    Care

    Management of

    ICU structure and

    medical support in

    remote ICUs

    Head of

    Department

    Senior Staff

    Member

    Senior Staff

    Member

    Staff Member with

    Combined Profile

    Management

    of non-COVID

    patients

    Communication

    support

    People

    management and

    training

    procedures

    Medical and

    practical

    management

    Back-up Members

    Crisis Unit

    Confidential

    Counselor

    Management

    Nursing

    Department

    Logistics,

    Materials, Drugs

    Senior Staff

    MemberNon-medical Head Nurses

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    STRUCTURED INTERVENTIONS – BOTTOM-UP INITIATIVES

    • Report status of capacity and infrastructure

    • Transmit needs to CEO, medical management, head of nursing, other hospital directors

    • Prepare adaptation process of ICU: discuss with stakeholders

    • Restrain non-urgent surgical procedures

    • Be in contact with Belgian National Society of Intensive Care: website was activated

    as a platform of information

    • Daily briefing on seven building blocks

    Macro level

    Internal and

    external

    stakeholders

    contact

    Head of

    Department

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    STRUCTURED INTERVENTIONS – BOTTOM-UP INITIATIVES

    • Treatment strategies: no non-invasive ventilation because too high viral load, remdesivir start at

    day one, EN and PN in nutritional approach…

    • Prepare for possible overflow and ethical decision making.

    • Design COVID-specific Standard Operating Procedures (intubation)

    • Choices in use of resources (Units and staff): move paediatric ICU to OR fertility department

    Operational

    management

    Medical and

    organizational

    command

    Senior Staff

    Member

    COVID-19 positieve patiëntenop IZ UZB

    Opvang en behandeling

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    OPTIMAL MEDICAL TREATMENT INCLUDING ECMO

    23GLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

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    STRUCTURED INTERVENTIONS – BOTTOM-UP INITIATIVES

    • Safety of Health Care Practitioners

    • Development Communication base, the centre of ICU

    • Be there: provide answers, gather questions and suggestions

    • WhatsApp group with >200 members in two days:

    >Reallocation of ICU units

    >Report on nr of treated COVID patients

    >Educational movies: how to wear protective clothes

    >Recordings of daily briefings

    >Practical callouts: urgent need of anti-fog for face shields

    Communication

    and staff

    well being

    Communication

    strategies

    Staff physical and

    psychological well-

    being

    Patient’s Family

    Care

    Senior Staff

    Member

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    STRUCTURED INTERVENTIONS – BOTTOM-UP INITIATIVES

    Creation of call centre

    • At ICU admission communication line was opened

    • Family members got medical information and kept track of their beloved ones

    • After one week 8 call takers worked under supervision of 2 MDs

    • Nurses and ICU MDs could focus on core business

    Psychological support

    • Unfavourable mental health outcomes reported in Chinese HCP exposed to COVID19 + harsh working

    circumstances

    • Psychologists present 2/d in coffee room, individual talks and handle panic attacks

    • Breathing exercise movie

    Communication

    and staff

    well being

    Communication

    strategies

    Staff physical and

    psychological well-

    being

    Patient’s Family

    Care

    Senior Staff

    Member

    25GLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    IGLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    CALL CENTER: PRACTICAL MANAGEMENT, FAMILY CONTACTS

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    MEDICAL STUDENTS LET PATIENTS TALK TO THEIR FAMILY

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    STRUCTURED INTERVENTIONS – BOTTOM-UP INITIATIVES

    • Upgrading of Coronary Care Unit to non-COVID ICU

    • Later stage: extra quarantine ICU beds

    • Additional staff: cardiologists and nephrologists followed crash courses in mechanical ventilation,

    inotropes and vasopressors, correct use of

    protective gear

    • Direct liaison with anaesthesiologists and dedicated ICU physicians

    Non-ICU

    environment

    (Coronary

    Care Unit,

    recovery room)

    Management of

    ICU structure and

    medical support in

    remote ICUs

    Staff Member with

    Combined Profile

    Management

    of non-COVID

    patients

    Medical and

    practical

    management

    Senior Staff

    Member

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    STRUCTURED INTERVENTIONS – BOTTOM-UP INITIATIVES

    • Day and night shifts, reallocation of nurses

    • Work with pharmacy, logistic department, facility care

    • Creation of new logistic areas, drug management

    • Communication between staff members

    • Professional approach daily briefings

    • Follow-up of activities of different working groups

    Communication

    support

    Back-up Members

    Crisis Unit

    Confidential

    Counselor

    Non-medical

    People

    management and

    training

    procedures

    Management

    Nursing

    Department

    Logistics,

    Materials, Drugs

    Head Nurses

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    IGLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    FOR

    ICU

    Head Nurse

    Head Emergency

    Department

    King Filip I

    of BelgiumCEO, Hospital

    UZ Brussels

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    WHAT ABOUT NUTRITION THERAPY?

    • Targets were set:

    >Protein BW x 1.3g = .. g

    >Calories: indirect calorimetry

    • To be reached by day 3-4

    • Enteral or combined with Supplemental Parenteral Nutrition

    Based on ESPEN Guidelines Critically Ill Patients

    NUTRITION COVID

    First choice = enteral

    Start prokinetics

    Start at 20 ml/h until target is known

    NO GASTRIC RV

    PN when EN is insuff or imposs

    31GLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    IGLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    Checklist Nutrition COVID19 Check

    New patient @ ICU

    Do Put feeding tube upon arrival or at time of intubation, check central line

    Start feeding

    Do Start tube feeding when lactate 65 even with vasopressors, muscle relaxant or prone position.

    How At 20cc/h of every formula (when 2kcal/ml start at 10ml/h)

    Refine and follow-up feeding

    Do Get to calories (kcal/day): indirect calorimetry or provide 25x bodyweight in kg

    Get to proteins (gram/day): provide 1.3x (adjust) bodyweight in kg

    How Put infusion pumps of enteral/parenteral on correct speed

    When enteral is not providing enough calories and proteins per day,

    (nutrition in mouth, DO NOT CHECK GRV) put parenteral on top on day 4 to cover caloric and protein goal

    Transition from ICU to the ward

    Do Do not pull out feeding tube or central line if still needed for nutrition (normal food covers less than 60% of needs)

    Communicate which kind of nutrition at what dose or follow-up yourself

    How Talk to colleagues who can do which part

    Stay safe

    Keep track of body weight, repeat indirect calorimetry once oxygen is gone, change targets. Phosphate 400 stop PN 2 days look again and restart.

    COVID19 UZBRUSSEL NUTRITION CHECKLIST BASED ON WWW.ESPEN.ORG GUIDELINES

    BRUSSELS 18TH MARCH 2020 ELISABETH, JOY, CHLOE, LODE.

    ESPEN GUIDELINES

    Available for free at:

    www.espen.org

    Available at Twitter

    @ElisabethWaele

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    http://www.espen.org/

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    WHAT ABOUT NUTRITION THERAPY?

    Based on ESPEN Guidelines Critically Ill Patients

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    179 READY TO USE PN BAGS IN 7 WEEKS

    For >150 COVID-19 ICU patients: 1.2 bags/patient

    0

    5

    10

    15

    20

    25

    30

    35

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    Use of Parenteral Nutrition

    PN SPN

    16-22

    March

    23-29

    March

    30 March –

    5 April

    6-12

    April

    13-19

    April

    20-26

    April

    27 April –

    3 May

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    DID IT ALL PAY OFF?

    Covid19 patient spend 5 weeks in ICU, different wards and now off to rehab

    Patients gave consent of use of pictures 35

    IGLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    Our first patient leaves ICU

    after intubation. Many will

    follow. Good job everyone!

    Patients gave consent of use of pictures

    “I am hungry and thirsty.

    After 5 weeks,

    my first yogurt!”

    Non-COVID 28-year old

    ICU patient spends

    3 months in ICU

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    IGLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    TAKE NUTRITIONAL THERAPY SERIOUSLY –

    ACT ON WHAT YOU PREACH

    ICU Dietitian Joy

    and MD Joop :

    Indirect calorometry

    on COVID patients

    First COVID-19

    ventilated patient

    leaves ICU in UZ Brussels

    CEO of hospital &

    Nutrition Nurse Lode

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    IGLBL/MG17/20-0021 06/2020 ©2020 Baxter Healthcare Corporation

    Checklist Nutrition COVID19 Check

    New patient @ ICU

    Do Put feeding tube upon arrival or at time of intubation, check central line

    Start feeding

    Do Start tube feeding when lactate 65 even with vasopressors, muscle relaxant or prone position. How At 20cc/h of every formula (when 2kcal/ml start at 10ml/h)

    Refine and follow-up feeding

    Do Get to calories (kcal/day): indirect calorimetry or provide 25x bodyweight in kg Get to proteins (gram/day): provide 1.3x (adjust) bodyweight in kg

    How Put infusion pumps of enteral/parenteral on correct speed

    When enteral is not providing enough calories and proteins per day, (nutrition in mouth, DO NOT CHECK GRV) put parenteral on top on day 4 to cover caloric and protein goal

    Transition from ICU to the ward

    Do Do not pull out feeding tube or central line if still needed for nutrition (normal food covers less than 60% of needs) Communicate which kind of nutrition at what dose or follow-up yourself

    How Talk to colleagues who can do which part

    Stay safe

    Keep track of body weight, repeat indirect calorimetry once oxygen is gone, change targets. Phosphate 400 stop PN 2 days look again and restart.

    COVID19 UZBRUSSEL NUTRITION CHECKLIST BASED ON WWW.ESPEN.ORG GUIDELINES BRUSSELS 18TH MARCH 2020 ELISABETH, JOY, CHLOE, LODE.

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    Thank you, Heroes!

    QUESTIONS?

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    Baxter is a trademark of Baxter International Inc.

    Thank you to all of those

    leading the fight against

    COVID-19

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