handbookbiohacker’s nutrition · fice she hangs up her coat, gets a cup fee and sits down for a...
TRANSCRIPT
1
BIO
HA
CK
ER’S
HANDBOOK
Upgrade yourself and
unleash your inner potential
Olli Sovijärvi / Jaakko H
almetoja / Teem
u Arina
03 N
UT
RIT
ION
Sold to Fred Block Block (#GJ57M
BGL)
2
Biohacker’s Handbook
Upgrade yourself and unleash your inner potential: N
utrition
Version: 1.0
Publisher:
Biohacker C
enter BH
C Inc.
PO B
ox 955
FI-00101 Helsinki, Finland
© O
lli Sovijärvi, Jaakko Halm
etoja, Teemu A
rina 2016
Layout and illustrations: Lotta Viitaniemi
Advisor and studio critic: D
r. Sam Inkinen
English translation: Salla William
s
ISBN
: 978-952-68458-0-7
This book is based on the personal experiences of its authors, and the advice it contains is based on a combination of
experience and scientific research. This book and the viewpoints that it expresses should not be treated as m
edical advice.
Consult w
ith your doctor before ordering or using any of the herbs or supplements m
entioned in this book.
Sold to Fred Block Block (#GJ57M
BGL)
3
How
can we achieve optim
al health?
We know
an approach that doesn’t w
ork: visiting the
doctor and obtaining prescriptions for pharmaceutical
drugs. D
espite over a trillion dollars of research
expenditures, few
curative drugs have b
een invented.
Antib
iotics for bacterial infections are alm
ost the
only candid
ate, and b
acteria are already evolving
resistance. Drugs often help m
itigate symptom
s, but
generally the underlying d
isease persists.
Diseases rarely go aw
ay, and aging b
rings new
disord
ers. By old
age, many have a long roster of
diagnosed
health conditions, and
an equally long
list of drug prescriptions. G
iven the failure of
pharmaceutical m
edicine, m
any have begun to
search for other means of healing.
I have been a part of that search. I d
eveloped a
chronic health condition w
hen I was taking a long
course of antibiotics for acne. Sym
ptoms such as
fatigue and m
emory loss got stead
ily worse for 15
years, until I worried I w
as developing early dementia.
After I d
iscovered the Paleo d
iet in 2005, I began
to make progress, but it took another 5 years of
research into nutrition and lifestyle to fully heal.
Eager to share what w
e’d learned
, my w
ife and I
started a blog, w
rote a book (Perfect H
ealth D
iet,
Scribner 2012), and
becam
e leaders of the ancestral
health movem
ent.
The ancestral health movem
ent is part of the larger
natural health movem
ent, which focuses on natural
interventions – diet and
lifestyle – as a means to
Preface Paul Jam
inet, Ph.D., author of the Perfect Health
Diet:
Regain
Health
and
Lose Weig
ht by E
ating
the W
ay You W
ere Mean
t to Eat
Sold to Fred Block Block (#GJ57M
BGL)
4
healing. The ancestral health movem
ent specifically
proposes that the best natural interventions are those
that mim
ic the ancestral or natural environment
experienced by wild anim
als and Pleistocene humans.
Based
on this principle our diet should
be a natural
whole food
s diet of plants and
animals, such as
ancient humans hunted
and gathered
; our lifestyle
should resem
ble the rhythmic life, attuned
to nature,
of hunter-gatherers who lack artificial light and
other mod
ern technologies.
Seeking to integrate natural health with the b
est of
mod
ern technology, a new m
ovement has arisen:
biohacking. Supported
by quantified self tools that
help us monitor personal health, it’s easier than ever
to do personal experim
ents and assess their effects
on health.
In principle, biohacking has the potential to achieve
an effective optimization of one’s personal health.
In practice, biohacking is not w
ithout risks. My
friend Seth R
oberts, an extraord
inarily creative man
who built his life around
the principle of self-experi-
mentation, d
ied prem
aturely from heart failure after
adopting a high-oil d
iet, to which he had
been led
by efforts to maxim
ize neurological performance.
High-fat d
iets are very good for nerve function, but
can be b
ad for the heart.
Self-experimenters like Seth face the problem
of
local optimization. In any experim
ental search
for one’s personal optimum
, one has to test small,
controlled interventions using b
iomarkers to
assess outcomes. A
successful experiment lead
s
to an improvem
ent in the biom
arker. Enough small
improvem
ents in enough biom
arkers, it is hoped, w
ill
lead to optim
al health.
But this strategy is like trying to get to the highest
place on earth by climb
ing uphill. Odd
s are you’ll
reach the top of a small hill, but you’ll b
e nowhere
near the summ
it of Mt. Everest.
Sold to Fred Block Block (#GJ57M
BGL)
5
To get to the summ
it of Everest by climb
ing uphill,
you have to start on the lower slopes of Everest. You
have to know w
here the summ
it is and get close to
it, before you b
egin searching for it. (It doesn’t hurt,
either, to have an experienced N
epalese Sherpa to
guide you.)
This is where the B
iohacker’s H
and
book and
its
authors, technology expert Teemu A
rina, nutritional
expert Jaakko Halm
etoja and m
edical d
octor Olli
Sovijärvi, can come to your aid
. Experienced b
io-
hackers all, they recognized the need for a biohacking
guide that could
give nascent biohackers an optim
al
starting point. They worked
for 3 years to generate
the Biohacker’s H
andb
ook.
One can quibble over ind
ividual b
its of advice, but
by and large, Teem
u, Jaakko, and O
lli have assembled
a compend
ium of the b
est wisd
om of the ancestral
health and the b
iohacking comm
unities. It’s a great
starting point for anyone’s health journey.
Follow the advice of the B
iohacker’s Hand
book,
and you’ll soon b
e feeling well. You’ll also b
e well
positioned to successfully execute any personal
experiments necessary to find
the diet and
lifestyle
that work b
est for you.
My first health advice: D
on’t climb
Everest without
a Sherpa, and d
on’t start biohacking w
ithout the
Biohacker’s H
andb
ook.
My second
: Don’t d
elay the journey. You have found
a guide; that is the b
est possible beginning. M
ay
your journey to good health b
e swiftly com
pleted!
Paul Jam
inet
Ph.D.author Perfect H
ealth D
iet
Sold to Fred Block Block (#GJ57M
BGL)
6
Dear reader! You are holding in your hands the
Biohacker’s Handbook, w
hich weaves together novel
perspectives on technology, nature and self-develop-
ment. The biohacker sees his or her body as a com
plex
system that can be probed, analyzed, understood,
and put to test. Such controlled experimentation (i.e.
biohacking) can be used to pursue self-development
and deeper self-understanding.
The idea for writing this book (w
hich combines studies,
insight and visual materials) w
as born from the insatible
thirst of its three authors for optimizing bodies and
minds, both on the individual and collective levels.
Technology expert Teemu A
rina, nutritional expert
Jaakko Halm
etoja and medical doctor O
lli Sovijärvi
met in the spring of 2013 to discuss the big challenges
of our time: w
ork pressure and incessant stress, and
their consequences to health and well-being.
This book is written for the busy person w
ho burns the
candle at both ends. Some have tried to find equilibrium
by lifestyle changes – for example through dietary
interventions, exercise routines and time m
anagement
techniques – only to end up back at square one. Indeed,
how can people learn to know
themselves, find a
balance, and successfully execute their plans for
change, when they are so stressed?
This book contains tools for those of you who are self-
made pioneers, journeying into the unknow
n, towards
a higher understanding of yourselves. It teaches you
to go deeper, to dismantle inner locks, to open new
doors, to test your own beliefs, and to overcom
e many
of the limits of your ow
n body and mind.
Whatever your background or goal, finding a balance
with your environm
ent is paramount.
Introduction Sold to Fred Block Block (#G
J57MBG
L)
7
Olli Sovijärvi, M
edical Doctor:
My reception takes care of each and every hum
an being in a holistic way, and provides individually
tailored health planning. A large proportion of m
y patients today have problems that are
increasingly brought on by chronic stress caused by a wide variety of factors. It is im
portant to seek out the root causes of illness and provide healing right at the source. From
this position we
can restore health, and also balance body, mind and spirit. By restoring our ow
n regenerative processes each of us can be cured of a num
ber of different illnesses.
The fundamental reason for w
riting this book is also based on the above lesson: self-recognition. The m
eaning of life is to recognize oneself and never stop learning how to becom
e better. To live is to be in m
otion and in play; staying put and becoming stagnant are the very opposite
of living. When a person com
es to terms w
ith him/herself, they can also m
uster the courage to be responsible for their ow
n well-being.
Jaakko Halm
etoja, Nutritional Expert:
I have always been interested in m
atters of health, physical stamina, the capacity of our m
inds and,m
ost importantly, the question: W
ho, or what, are w
e really? For many years now
I have allowed
myself to pause, every now
and then, in order to discover the deeper underlying directions and passions of m
y life. Every time the correct answ
er has been practically staring me in the face. So
how does the body of the hum
an being function? Who am
I really?
Listening to the signals sent by our own bodies, and pausing in the m
iddle of today’s information
overload, can be a daunting task, with the noise of the traffic and the seem
ingly endless list of tasks ahead. N
ew technologies can offer tools to listen to yourself and to upgrade yourself.
Sold to Fred Block Block (#GJ57M
BGL)
8
“There is hope in men, not in society, not in system
s, not in organized
religious systems, but in you and
in me.”
– Jiddu K
rishnamurti
Teemu A
rina, Technology Expert: Technological developm
ent has made it possible to know
one’s self in unprecedented ways.
A num
ber of technologies, and sources of information, that w
ere previously available only for
the privileged few, are now
available for everybody. After curing m
yself of a stress-related illness
by measuring m
yself with the help of various technological tools, sensors, internet databases,
experts in different fields and personal experiments, I am
convinced that technology is an
extension of our bodies and minds.
The Biohacker’s Handbook treats the hum
an organism as com
plicated machinery. H
ow does this
system actually w
ork? Whether it’s your sleep, w
ork, exercise, nutrition, or mind that you w
ish to
improve upon, the book provides access to “hackable” system
s and a guide to upgrading them
with the help of technological and biological tools. Since the perceived changes and actual effects
vary from individual to individual, w
e provide tools for personal experimentation, m
onitoring and
measurem
ent.
Know yourself and upgrade yourself, so you can give m
ore to others.
Sold to Fred Block Block (#GJ57M
BGL)
9
Increased productivity
Reducedstress
Lifeextension
Increased perform
anceIm
provedhealth
UPGRADE
YOURSELF
Nutrition
SleepM
ind
Work
Exercise
Sold to Fred Block Block (#GJ57M
BGL)
10
Use your m
obile device to read the following Q
R code,
or open the link in your browser, to have access to the
book’s bonus materials:
Please use the above site to give us feedback and
suggestions and, and if you find our advice useful,
tell your friends about the book.
How
to use this book
Each chapter of the book is composed of four essential parts:
If you need a QR code reader, open the follow
ing link
into a browser, http://biohack.to/qr, and dow
nload a
suitable application.
In addition, the book’s bonus materials (biohack.to/
nutrition) contains product recomm
endations, bonus
materials, videos, audio recordings, book and article
recomm
endations, references with hyperlinks, and the
opportunity to send us your feedback. These features
are accessible in a browser or a m
obile device.
1.2.3.4.
An introduction based on a story.
A theoretical section that discusses the
hackable systems.
A technological section that describes the
biological and technological tools needed for upgrading oneself.
A m
easurement section that describes the
tools needed to track progress.
biohack.to/nutrition
Sold to Fred Block Block (#GJ57M
BGL)
12
“One should
eat to live, not live to eat.”– M
olière (1622–1673)
“Let the food b
e thy med
icine and m
edicine
be thy food
.” – Hippocrates (460–370 B
CE)
“All things are poison, and
nothing is w
ithout poison: the dose alone
makes a thing not poison.”
– Paracelsus (1493–1541)
“Most people w
ork hard and
spend their
health trying to achieve wealth. Then they
retire and spend
their wealth trying to get
back their health.” – D
alai Lama (b. 1935)
Sold to Fred Block Block (#GJ57M
BGL)
13
Mary shuffles into the kitchen w
hile rubbing the sleep
out of her eyes. Feeling lethargic, she tries to think of
something convenient to take on the go. She throw
s
a yogurt and a banana into her bag and starts the car.
The morning traffic craw
ls along slowly. M
ary snacks on
the banana she brought along to postpone the hunger.
Once at the office she hangs up her coat, gets a cup
of coffee and sits down for a chat w
ith her colleagues.
Half an hour later, she refills her coffee cup and heads
for her desk. Mary feels restless and has difficulty
concentrating. The important project on her plate w
ill
have to wait until the afternoon. Responding to em
ails
feels less exhausting for now.
At lunch M
ary selects basic cafeteria fare: a white bread
sandwich w
ith mayonnaise sauce, deli m
eat and a few
lonely pieces of salad and cucumber. It fills the stom
ach
but she feels fatigued. It’s as if her brain was surrounded
by fog. Mary daydream
s about taking a long nap as
soon as she gets home.
The clock strikes five and Mary grabs her bag. There’s
a text message from
her husband: “Remem
ber to
get groceries on your way hom
e.” The supermarket
is busy as ever with everyone hurrying to get hom
e.
Mary roam
s the familiar aisles and collects m
ilk, bread,
juice, cheese, ham, yogurt and cookies in her cart. For
the kids, she picks up mac &
cheese, canned soup and
frozen lasagna. Finally, she adds a bottle of soda and a
few bottles of beer.
At the check-out, M
ary notices the radiant appearance
of the wom
an in front of her in the line. Her skin looks
amazingly sm
ooth. Her shopping basket is full of
vibrant colors: vegetables, berries and fresh produce.
A thought surfaces in M
ary’s mind: C
ould it be that her
radiant skin and positive appearance have something
to do with the food choices in her basket? H
owever,
the thought quickly passes as Mary rem
embers her
hungry family w
aiting at home.
“I gu
ess I shou
ld eat
someth
ing...”
Sold to Fred Block Block (#GJ57M
BGL)
14
Bear: Th
e Kin
g of th
e Forest
The archetype of nutrition in this book is the bear, one of
the largest land predators in the Western w
orld. The bear
is the totem of m
any indigenous peoples, a revered and
respected animal, and the sym
bol of the tribe and family.
Most bear species are om
nivores with predom
inantly
vegetarian diets. How
ever, different species have adapted
to their respective environmental challenges and there
is significant variation between them
. Polar bears’ diet
mainly consists of seals w
hereas pandas exclusively eat
bamboo shoots. A
lthough North A
merican and N
ordic
bears acquire most of their nutrition from
plants, they are
also opportunistic carnivores. They are known to eat for
example vegetables, berries, fish, m
ushrooms and honey.
During the spring season, bears m
ay also hunt elk.
Like bears, most people are also om
nivores with pre-
dominantly vegetarian diets. H
uman beings are capable
of adapting to their environment, using a variety of
ingredients for sustenance. The goal of the Nutrition
chapter of the Biohacker’s Handbook is to crystallize
the special nutritional characteristics, opportunities and
practical solutions for people in various circumstances,
working w
ith different goals and resources.
Sold to Fred Block Block (#GJ57M
BGL)
16
“Tell me w
hat you eat, and I w
ill tell you what you are.”
– French gastronome
Jean Anthelm
e Brillat-Savarin (1755–1826)
Food brings people together. It is a source of pleasure
and the foundation that makes other aspects of life
flourish. The intelligent optimization of nutrition is a top
priority in the daily life of a biohacker.
A significant challenge in nutrition is the regrettably
comm
on dualistic habit of dividing ingredients into
good and bad options. How
ever, nutrition is not as
black and white as it m
ay seem at first glance, for
instance, in the controversial case of fats vs. sugars.
The effect that food has on us varies depending on
the quality of the ingredients, the processing methods
used, as well as individual factors.
Individ
ualThe follow
ing pages outline the effects of food on
your body and health from deeper perspectives. The
traditional and restricted division of ingredients into
specific diets will not be used; rather, their detailed
characteristics are examined as part of the big picture.
Some highlighted features include the effects of ingre-
dients on various equilibria of the system, preparation
and processing methods that increase nutrient intake,
and the basis of genetics and epigenetics.
The biohacker assumes an individual approach to nutri-
tion while taking into consideration the quality factors
of the ingredients and their expected effects on the
body. Food choices are not limited to the m
ainstream
favorites – less well know
n options are also explored.
The biohacker sees nutrition as technology to be used
for leverage in the challenges of everyday life.
Op
timal
We are all aw
are of the official dietary guidelines
and the general nutrient intake recomm
endations.
Simplification and generalization are both the strength
and the weakness of these recom
mendations m
ade for
the general public.
Sold to Fred Block Block (#GJ57M
BGL)
17
The general nutrient intake recomm
endations often
represent the threshold at which the risk to develop a
certain illness is greatly reduced. How
ever, demographic
averages are not necessarily relevant for the optimal
levels of an individual. Vitamin D
is a good example.
Genetic variation in the vitam
in D receptor (VD
R) in
individuals affects the absorption of calcium and there-
fore the recomm
ended intake. 1
Diverse
The improved standard of living is not fully reflected
by improvem
ents in nutrition. Today, we spend propor-
tionally less money on food and our connection to the
origin of the food we eat is w
eaker than ever before. As
the diversity of food has decreased, many illnesses that
were rare in our ancestors have increased.
There are approximately 50.000 edible plants
in the world. The 15 of those m
ost widely used
represent roughly 90 % of energy intake. Rice, corn
and wheat alone feed approxim
ately 60 % of the
world’s population. 2 To com
pare, throughout human
history, our diet has included at least a hundred plant
species depending on the local habitat. It is worth
remem
bering that in a market econom
y, supply will
meet dem
and: our purchasing choices determine
the direction in which the food industry develops our
nutrition. The biohacker is now equipped w
ith the latest
research findings and the most advanced technology
available to bring nutrition to a personalized level.
10 MO
ST IMPO
RTAN
T CRO
PS IN TH
E WO
RLD (2008)
Source: Allianz
Sold to Fred Block Block (#GJ57M
BGL)
18
1. Eat well for tom
orrow, not just for today.
2. Improve your health even w
hen you are healthy.
3. Quality over quantity.
4. Increase the nutritional density of your food.
5. Reduce toxins.
6. Maintain a healthy balance of various ingredients.
7. Don’t eat term
s. “Low fat” or “sugar-free” does not
necessarily m
ean a healthier option.
8. Adopt nutritional principles and strategies to apply
in different situations.
9. View m
ealtimes as m
eans to share experiences
and know
ledge.
1. The ability to intelligently utilize the nutritional
resources available, even in challenging situations.
2. The means to m
aintain energy levels, clarity of
m
ind and other objectives relevant to life and
w
ell-being.
3. The knowledge and ability to increase one’s ow
n
health and w
ell-being.
1. Add natural, vibrant colors and flavors to your diet.
2. Invest in the quality of ingredients, particularly for
the products you use the m
ost.
3. Regularly measure and analyze the effects of food on
your system
. OB
JEC
TIV
ES
CO
MPA
SS
BIO
HA
CK
ER
’S N
UT
RIT
ION
M
AN
IFEST
O
10. Consider the environm
ent when m
aking choices,
both in the short and long term
.
Sold to Fred Block Block (#GJ57M
BGL)
19
STRU
CTU
RE
AN
D FU
NC
TION
S O
F THE
DIG
ESTIV
E SY
STEM
19
Sold to Fred Block Block (#GJ57M
BGL)
20
The digestive systemconsists of organs w
hose func-
tions involve digestion, nutrient
absorption, waste product rem
oval
and the formation of feces.
The digestive tract reaches from
the mouth all the w
ay to the
anus. The most im
portant parts
of the digestive tract in terms
of functions are the esophagus,
stomach and duodenum
in the
upper gastrointestinal tract and
the jejunum, ileum
, colon and
rectum in the low
er gastroin-
testinal tract. The digestive
system also includes the salivary
glands, pancreas, liver, spleen
and gallbladder, each with their
own role in digestion.
The main function of the digestive system
is to break down food and absorb
nutrients from the sm
all intestine into
the circulatory system. D
igestion can
be divided roughly into two functional
phases: mechanical digestion (the food
is broken into smaller pieces by chew
-
ing) and chemical digestion (enzym
es
break down food into m
olecules).
The importance of chew
ing for nutrient
absorption is often insufficiently con-
sidered. Eating slowly and chew
ing the
food thoroughly may create a greater
feeling of fullness and increase the
absorption of nutrients. 3
Another im
portant function of the
digestive system is the m
aintenance
of the body’s defense system against
pathogens. This is discussed in more
detail in the ”Microbiom
e” section.
Sold to Fred Block Block (#GJ57M
BGL)
23
PAR
TS OF TH
E D
IGE
STIVE
SYSTE
M
Stomach
The stomach is located
between the esophagus
and the duodenum in
the top left corner of the
abdominal cavity, im
medi-
ately below the diaphragm
.
The stomach contains tw
o
sphincters that control the
volume and m
ovement of
the stomach contents: the
lower esophageal sphincter
and the pyloric sphincter
allow the m
ass of food to
enter the duodenum.
The capacity of an empty adult stom
ach is approxi-
mately 75 m
illiliters (2.54 ounces). It can take in roughly
a liter of food. 4 The stomach secretes gastric juice
which contains horm
ones and enzymes necessary for
digestion, hydrochloric acid for breaking down food
and intrinsic factor (IF) required for the absorption of
vitamin B
12. 5
The acidity of gastric juice destroys harmful m
icro-
organisms present in food. H
owever, m
any people suffer
from a deficiency in the production of hydrochloric
acid due to stress, poor diet or harmful chem
icals. 6
Hypochlorhydria (the low
level of hydrochloric acid)
contributes to nutritional deficiencies, osteoporosis, 7
various infections, 8 and stomach cancer. The long-term
use of acid blockers may cause anem
ia, 9 vitamin B
12
deficiency, 10 and overgrowth of stom
ach and intestinal
bacteria. 11
Sold to Fred Block Block (#GJ57M
BGL)
24
Enzyme / other
compound
Pepsin
Lipase
Intrinsic factor
(IF)
Mucin
Gastric
lipase
Function in the stomach
Breaks dow
n proteins into peptides
Breaks dow
n fats into fatty acids
Binds to vitam
in B12 and prom
otes its
absorption in the small intestine
Mucous m
atter that protects the
stomach lining from
damage
Breaks dow
n fats into fatty acids
Horm
one
Gastrin
Histam
ine
Cholecystokinin
Somatostatin
Gastric inhib
itory
pep
tide (G
IP)
Enteroglucag
on
Leptin
Ghrelin
Function in the stomach
Promotes the form
ation of hydrochloric
acid and increases gastric movem
ent
Contributes to the regulation of
stomach acidity through H
2 receptors
Curbs the em
ptying of the stomach
Inhibits the secretion of gastrin,
secretin and histamine in the stom
ach
-> slow
s down digestion
Inhibits the secretion of hydrochloric
acid and reduces gastric movem
ent
Inhibits the secretion of hydrochloric
acid and reduces gastric movem
ent
Regulates appetite
Stimulates appetite and prom
otes the
emptying of the stom
ach
Sold to Fred Block Block (#GJ57M
BGL)
25
Small intestine
The small intestine is located
between the stom
ach and
the colon. The small intestine
forms a coil-like structure
roughly seven meters in
length. It is located in the
abdominal cavity, surrounded
by the colon. The small
intestine consists of the duo-
denum, jejunum
and ileum.
The small intestine receives
pre-digested food from the stom
ach and continues
to break down ingredients. The digestive process is
assisted by bile (formed in the liver but secreted
through the gallbladder) as well as pancreatic juice
which contains plenty of digestive enzym
es.
The small intestine breaks dow
n three main groups of
nutrients: proteins, fats and carbohydrates. Proteins
are broken down into peptides and am
ino acids. Fats
are broken down into fatty acids and glycerol. C
arbo-
hydrates are broken down into m
onosaccharides (for
example glucose) and starch into oligosaccharides.
Once broken dow
n, the nutrients are absorbed through
the intestinal wall. Thanks to the structure of the sm
all
intestine villi and microvilli, the surface area available
for nutrient absorption is enormous, roughly one half of
a badminton court. 12
Enzyme
Am
ylase
Lactase(not present or deficient in 75%
of the w
orld population)
Maltase
Sucrase
Function in the small intestine
Breaks dow
n carbohydrates into
shorter chains of saccharides or sugars
Breaks dow
n lactose into glucose
and galactose
Breaks dow
n maltose into glucose
Breaks dow
n sucrose into fructose
and glucose
Sold to Fred Block Block (#GJ57M
BGL)
26
Horm
one
Cholecystokinin
Secretin
Vasoactive
intestinal
pep
tide (V
IP)
Enteroglucag
on
Glucag
on-like
pep
tide-1
Function in the small intestine
• Stimulates gallbladder contractions
and intestinal m
ovements
• Stimulates the secretion of insulin,
glucagon and pancreatic polypeptides
• Stimulates the secretion of pancreatic
bicarbonate, enzym
es and insulin
• Curbs the m
ovements of the stom
ach
and sm
all intestine
• Inhibits the secretion of gastrin
• Relaxes the smooth m
uscles of the
intestine, and prom
otes the secretion
of w
ater and electrolytes in the
pancreas and sm
all intestine
• Releases other hormones from
the
pancreas, intestine and hypothalam
us
Inhibits the secretion of insulin
Promotes the secretion of insulin
Enzyme
Glucoam
ylase
Trypsin
Chym
otrypsin
Am
inopep
-
tidase and
dip
eptid
ase
Lipase (several
types) 13
Phospholip
ase
(several types) 14
Function in the small intestine
Breaks dow
n glucose polymers (for
example starch) into glucose
Breaks dow
n proteins into amino acids
Breaks dow
n proteins into amino acids
Break dow
n polypeptides and
dipeptides into peptides and amino
acids
Breaks dow
n triglycerides into fatty
acids and glycerol
Breaks dow
n phospholipids into
fatty acids and other fat-soluble
substances
Sold to Fred Block Block (#GJ57M
BGL)
27
Colon
The colon is located be-
tween the sm
all intestine
and the anus. It is roughly
1.5 meters long and consists
of the cecum, ascending
colon, transverse colon,
descending colon and
sigmoid colon. The colon
is located in the abdominal
cavity where it surrounds
the small intestine.
The functions of the colon include the maintenance
of the bacterial strain in the intestine as well as the
absorption of water and the rem
aining nutrients before
the feces move on to the rectum
. The vitamins absorbed
include K vitamins, thiam
ine (B1) and riboflavin (B
2). 15
The colon turns digested food into fecal matter. The
bacterial strain in the intestine feeds on the fiber mass
in the feces and produces fatty acids which are used as
a source of energy (see the “Microbiom
e” section for
more details). 16 The bacteria also help rem
ove waste
products and toxins.
The appendix is located below the cecum
in the colon. It
produces hormones that regulate eating (peptides). The
appendix acts as a storage space for beneficial bacteria17
and may offer protection from
some infections. 18 A
pop-
ular notion in medicine is that the appendix is unneces-
sary and may be rem
oved in the event of adulthood
appendicitis. Recent studies suggest that treatment
with antibiotics w
ill often lead to equally good results. 19
For example in Finland the prevalence of inflam
matory
bowel diseases (IB
D), such as ulcerative colitis and
Crohn’s disease, has nearly tripled in the past 15 years. 20
There is a link between the W
estern diet consisting of
large amounts of processed food and the developm
ent
of inflamm
atory bowel diseases. 21 These diseases m
ay
appear in genetically predisposed individuals due to
changes in the bacterial strain of the intestine and
disturbances in the imm
une response. According to the
latest research, these diseases are also linked to the
leaky gut syndrome and an environm
ental trigger
factors such as an infection. 22
Sold to Fred Block Block (#GJ57M
BGL)
28
A diet that rem
oves potentially intestine-damaging
antinutrients (see the “Antinutrients”section for m
ore
details) and reduces inflamm
ation is usually very
beneficial for recovery from the illness. 23 Specifically,
the role of gluten24 in the developm
ent of IBD
and the
genetic link to celiac disease have been indicated in
recent studies. 25 Based on the review
of recent
research (2014), the majority of IB
D patients benefit
from rem
oving gluten from their diet. 26
Pancreas
The pancreas is located in the abdominal cavity, behind the stom
ach and next to the
spleen, surrounded by the duodenum. The pancreas is connected to both the sm
all
intestine and the gallbladder. The pancreas has two distinct functions: the endocrine
part that consists of millions of islets (2 %
of the pancreas) secretes hormones such as
insulin and glucagon, while the exocrine part (98 %
of the pancreas) boosts the
digestive process.
Sold to Fred Block Block (#GJ57M
BGL)
29
Enzyme
Trypsinog
en
Chym
otryp-
sinogen
Carb
oxy-
pep
tidase
Pancreatic
lipase
Phospholip
ase
Pancreatic
amylase
Nucleases
Elastase
(several)
Function in the pancreas
Is converted into trypsin by entero-
peptidase28 in the sm
all intestine
Is converted into chymotrypsin by
enteropeptidase in the small intestine
(see small intestine)
Cleaves am
ino acids at the ends of
proteins
Breaks dow
n triglycerides into fatty
acids and glycerol
Breaks dow
n phospholipids into fatty
acids and other fat-soluble substances
Breaks dow
n starch and glycogen into
glucose
Break dow
n nucleic acids (DN
A and RN
A)
Breaks dow
n elastin and a few other
proteins into amino acids
Horm
one
Glucag
on
(from alp
ha
cells)
Insulin
(from b
eta
cells)
Somatostatin
(from d
elta
cells)
Pancreatic
polyp
eptid
e
(from g
amm
a
cells)
Function in the pancreas
• Raises the concentration of glucose
in the blood by converting glycogen
stored in the liver and m
uscles
• Lowers the concentration of glucose
in the blood by prom
oting its absorp-
tion into m
uscles and adipose tissue
• Other m
etabolic effects (see section
“B
lood sugar regulation” for more
details)
• Inhibits the secretion of insulin and
glucagon
• Inhibits the secretion of digestive
enzym
es
• Regulates the secretion functions
of the pancreas (endocrine and
exocrine)
• Increased secretion after eating ->
reduced appetite, less food eaten
27
Sold to Fred Block Block (#GJ57M
BGL)
30
Liver
The liver is located in the
top right corner of the ab-
dominal cavity, im
mediately
below the diaphragm
, to the
right of the stomach. Below
the liver is the gallbladder.
Com
pared to other internal
organs, the liver has a double
blood supply via the portal
vein and the hepatic
arteries.This is indicative
of the importance of the
liver to the entire system.
The liver also contains the bile duct system w
hich
collects the bile produced by the liver. Bile ducts
generally refer to all ducts through which bile travels
from the liver to the gallbladder and duodenum
.
Main functions of the liver: 29
• Carbohydrate m
etabolism:
– Produces glucose from
amino acids, lactic acid
and glycerol
– B
reaks down glycogen into glucose
– Form
s glycogen from glucose
• Fat metabolism
:
– O
xidizes fatty acids into energy
– Produces large am
ounts of cholesterol, phospho-
lipids and lipoproteins (such as LD
L, HD
L, VLDL)
• Protein metabolism
:
– B
reaks down am
ino acids
– C
onverts toxic amm
onia into urea (urea cycle)
– Produces blood plasm
a proteins (including albumin)
– Produces am
ino acids and converts them into other
com
pounds
• Bile secretion
• Production of red blood cells and coagulation agents
• Storing glucose (glycogen), fat-soluble vitamins (A
, D,
K) and vitam
in B12, iron and copper
Sold to Fred Block Block (#GJ57M
BGL)
31
Cleaning
and d
efense functions:
• Breaks dow
n several hormones (including insulin)
• Breaks dow
n and neutralizes toxins (detoxification)
• Removes (through urine) bilirubin released by red
blood cells
Liver disease mortality has tripled in the last 40 years. 30
Today's stressful work culture, alcohol, problem
atic
diet and other environmental burdens have led to
impaired liver function in som
e individuals. 31 Abdom
inal
obesity in particular contributes to the development
of fatty liver disease. 32 Various medicines also have a
significant role in the development of liver dam
age.
More than 900 m
edicines have been reported to cause
liver damage. O
ne half of all acute cases of liver failure
are caused by various medicines. 33 Som
e medicinal
herbal products may also be harm
ful for the liver. 34
The liver has an amazing ability to regenerate. Indeed,
it is the only internal organ that is capable of this. Even
when 75 %
of the liver has been destroyed, it may return
to a normal state. 35 The functions of the liver can be
supported through nutrition. This involves supporting
the cytochrome P450 enzym
e system w
hich is central to
the liver detoxification function. The system consists of
two distinct phases (1 and 2). 36
FAC
TH
epatitis C, fatty liver, an
d alcoh
ol
abu
se are the m
ost comm
on
causes of cirrh
osis of the liver.
Betw
een 10 an
d 20 p
ercent of
heavy d
rinkers w
ill develop
cirrhosis. N
early 88 000 peop
le
die of alcoh
ol related d
iseases.
It is the fou
rth lead
ing cau
se of
death
in th
e Un
ited S
tates.
Source: Stahre, M. &
Roeber, J. & Kanny, D
. & B
rewer, R.
& Zhang, X. (2014 ). C
ontribution of excessive alcohol consum
ption to deaths and years of potential life lost in the U
nited States. Preventing Chronic D
iseases 11: E109.
Sold to Fred Block Block (#GJ57M
BGL)
32
ToxinsPhase 1C
onverting foreign matter into
harmless com
pounds. Supporting nutrients:
• Vitamin B com
plex• G
lutathione (the main
antioxidant in the liver)
• Branched-chain amino acids
(BC
AA
)• Flavonoids• Phospholipids• C
arotenoids• Vitam
in C• Vitam
in E• Selenium
, zinc, copper and
manganese
• Ubiquinone (coenzym
e Q10)
• Silybum m
arianum (M
ilk thistle)• A
rtichoke • Turm
eric• C
ruciferous plants (such as
broccoli)• G
rapefruit
• Alpha lipoic acid (A
LA)
• N-acetylcysteine (N
AC
)• C
alcium D
-glucarate• M
SM• A
mino acids:
– Glycine
– Taurine – G
lutamine
– Cysteine
– Methionine
• Ingredients that contain sulfur: – Egg – C
ruciferous plants – G
arlic and other onions
Phase 2
Including meta-
bolic byproducts, pesticides, envi-ronm
ental toxins, additives and m
edicines.
A w
ater-soluble molecule is
bound to the substance to be rem
oved in order for the com-
pound to be safely removed
through the intestine or the kidneys. Supporting nutrients:
Exit from
the bod
y:
Gallb
ladd
erK
idneys
FecesU
rine
Detoxification m
echanism of the liver
Sold to Fred Block Block (#GJ57M
BGL)
33
Gallb
ladd
er
The gallbladder is located
below the right lobe of the
liver. It is a small organ,
approximately 8 centim
eters
in length, and its main func-
tion is to store the bile pro-
duced by the liver. The gall-
bladder and the hepatic duct
merge to form
the bile duct
which leads bile into the sm
all
intestine from the am
pulla
of Vater (a merging point
with the pancreatic duct). 37
Bile is secreted from
the gallbladder into the small
intestine during the digestive process. Bile facilitates
the formation of m
icelles which are essential for the
absorption of fats. Bile also has an im
portant role in the
absorption of fat-soluble vitamins (A
, D, E and K) and
the recycling of bilirubin in the body. 38 Bile acids func-
tion in a manner sim
ilar to hormones, participating in
metabolism
(energy balance, regulation of fat meta-
bolism and glycem
ic control). 39
Deficiency in the production of bile and bile acids m
ay
cause significant health problems such as excess w
eight
and insulin resistance. 40 The gallbladder may also form
gallstones due to indigestion or imbalanced diet. For
instance a deficiency in the production of bile salts in the
liver, in combination w
ith a diet rich in cholesterol, may
be a predisposing factor for the formation of gallstones. 41
Risk factors contributing to the formation of gallstones
include excess weight, rapid w
eight loss, constipation
and the decreased intake of fiber and nutrients (folate,
magnesium
, calcium and vitam
in C). A
dietary supplement
of vitamin C
may prevent the form
ation of gallstones. 42
Melatonin m
ay also be used to prevent the formation
of gallstones and possibly even treat cholelithiasis. 43
Ingredients and compounds that prom
ote the production
of bile and
bile acid
s as well as the flow
of the bile are:
• Soluble fiber
(for example from
oats)
• Phenolic compounds
(for example from
artichoke)
• Turmeric
• Flavonoids
• Orange
• Dandelion
• Bitters
Sold to Fred Block Block (#GJ57M
BGL)
34
MIC
RO
BIO
ME
The microbiom
e refers to the colonies of symbiotic
(both parties benefit from each other), com
mensal
(one party unilaterally benefits from the other) and
pathogenic (illness-causing) micro-organism
s. These
colonies exist for example on the skin's surface, on the
mucous m
embrane of the m
outh, the conjunctiva and
the intestine.
It is estimated that there are 500–1000 distinct bacterial
species living in the intestine. The most com
mon
bacterial species in the intestine are Bacteroides,
Blostridium
, Fusobacterium and B
ifidobacterium. O
ther
known strains include Escherichia and Lactobacillus. 46
The Bifidobacterium
and Lactobacillus strains are
typically present in probiotic products due to the fact
that these are most w
idely studied. 47
The functions of the bacteria in the intestine include
breaking down carbohydrates (ferm
entation) that the
body cannot otherwise digest. This process creates
short-chain fatty acids which are used for energy in
the organism. For exam
ple butyrate is utilized by the
surface cells of the intestine, propionate by the liver
and acetate by muscle cells. 48
Therefore, the condition of the intestine also has a
significant influence also on energy production. The
intestinal bacterial strain also contributes to the
absorption of K vitamins, B
vitamins and som
e minerals
(magnesium
, calcium and iron), the production of bile
acids as well as the im
mune system
. Furthermore, it
acts as a protective wall against various pathogens. 49
FAC
TD
id you know
that only 40–50 % of
the cells in your system are of hum
an
origin? The other 50–60 % is m
ade up
of the cells of the bacteria, fungi and
micro-organism
s living in your body. 44
In terms of genes, the d
ifference is
much greater – for each hum
an gene
there are 100 micro-organic genes. 45
Sold to Fred Block Block (#GJ57M
BGL)
35
Antib
iotics affect the bacterial strain
of the intestine A
single course of antibiotics can affect as much as 30 %
of the entire bacterial flora of the intestine and can throw
off the bacterial balance for six months up to tw
o years. 50
How
ever, antibiotics are necessary when a harm
ful patho-
genic bacterium, such as Salm
onella, Shigella, Cam
pylo-
bacter or Yersinia, has entered the intestine. Alongside
viruses, these bacteria are also the most com
mon
causes of traveler's diarrhea and intestinal infections.
Depending on the individual’s bacterial balance, the
liberal use of antibiotics may cause predisposition to
diarrhea51 and the clostridium
difficile infection52 as
well as overgrow
th of other harmful bacteria. 53 The
increased use of antibiotics has also resulted in an in-
crease in antibiotic resistant bacteria around the world. 54
THE D
EVELOPM
ENT O
F A
NTIB
IOTIC
RESISTAN
T BA
CTERIA
1. Antibiotic is given to
farm anim
als to keep them
healthy
2. Antibiotic protects anim
al against know
n strains of bacterial infection
3. Mutated form
of bacteriaresists antibiotic,
contaminates m
eat4. H
umans are infected by
mutant bacteria after
consumption of infected m
eat 5. Same antibiotics given to
humans has no effect as the
pathogen is already imm
une
Sold to Fred Block Block (#GJ57M
BGL)
36
Gut-b
rain axisThe gut-brain axis refers to the neurological and
biochemical connection betw
een the enteric nervous
system of the intestine and the central nervous system
.
The intestinal microbiom
e (bacterial strain) is known to
affect the function of the imm
une system, the nervous
system, 55 behavior, 56 stress tolerance, 57 m
ood58 and
issues such as anxiety and depression. 59 In the past
two decades in particular there has been a grow
ing
understanding of the significance of the intestine for
the well-being of the brain.
The brain comm
unicates with the intestine via tw
o dis-
tinct autonomic branches of the nervous system
: the HPA
axis (hypothalamus – pituitary gland – adrenal gland) and
the sympathetic nervous system
– adrenal gland axis
which regulates the lym
phatic system of the intestine. 60
It is important to understand the continuous nature of
the comm
unication between the brain and the intestine
and the bilateral regulatory mechanism
s involved. A
good example of this is a strong em
otional reaction
that causes “butterflies in the stomach.”
61 Conversely,
the intestine sends the brain information about the
food eaten and its effects on the intestine.
GU
T-BRA
IN A
XIS
The intestine affects the
brain
The brain affects the intestine
Gut-brain axis
Cooperation betw
een the m
icrobiome and the intestine
Sold to Fred Block Block (#GJ57M
BGL)
37
The first signs of impaired brain function m
ay also be
detectable in digestion – the impaired secretion of
pancreatic enzymes, w
eak gallbladder activity and
the general impairm
ent of intestinal balance and
function. 62
Vicious circle
The bilateral nature of comm
unication between the
brain and the intestine may form
a so-called vicious
circle (circulus vitiosus).
The continuous inflamm
atory condition or imbalance
of the intestine may cause deterioration of the links
between the enterocytes on the surface of the
intestine, causing gut permeability. Sim
ilarly, impaired
brain function or stress-related hyperactivity of the
sympathetic nervous system
undermines the function
of the vagus nerve. 63 This impairs the function of the
imm
une system and reduces blood circulation in the
intestine which in turn increases the grow
th of harmful
fungi and bacteria in the intestine. 64 They can damage
the surface tissue of the intestine and aggravate gut
permeability (leaky gut syndrom
e). 65 66
A continuous low
-grade inflamm
ation of the system
may also aggravate gut perm
eability. 67 68 This results in
the production of cytokines (inflamm
atory messenger
substances) in the intestine. 69 Due to gut perm
eability,
the messenger substances are able to enter the
circulation and the brain via the blood-brain barrier.
VICIO
US C
IRCLE
Sold to Fred Block Block (#GJ57M
BGL)
38
The inflamm
ation causes the blood-brain barrier to
also become perm
eable, which in turn activates the
connective tissue cells of the brain, also known as
microglia cells. 70 The result is a chronic inflam
matory
condition of the brain that impairs brain function and
may cause anxiety and depression. 71
Thus completing the vicious circle w
hich will get w
orse
unless corrective measures such as those outlined in
this book are implem
ented.
INFLA
MM
ATORY C
YCLE
Sold to Fred Block Block (#GJ57M
BGL)
40
STOO
L CO
LOR
DEFEC
ATION
POSITIO
N
Light to medium
brown
Norm
al
YellowG
allbladder problem or parasitic infection (G
iardia)
Sold to Fred Block Block (#GJ57M
BGL)
42
Many ingredients
affect the digestive
system both positively or negatively. A
llergenic foods,
toxins occurring naturally or artificially in food, and
intestinal bacteria reacting to food all represent unique
challenges. On the other hand, m
any ingredients
reduce the inflamm
atory reaction of the intestine,
facilitate the digestive process or provide materials
necessary for tissue regeneration.
Allerg
enic and hyp
ersensitivity-inducing
food
sA
food allergy is an adverse imm
une response to a
particular protein in the food. The imm
une system
treats the foreign protein as harmful, causing a quick
antibody response (imm
unoglobulin E). Food allergies
unrelated to the imm
unoglobulin E reaction, such as
celiac disease and enterocolitis, are more rare. Factors
that may increase the likelihood of allergies include
the liberal intake of antibiotics in early childhood, 72
the allergenic diet of the mother, 73 certain vaccines
74 75
and particularly the adjuvants thereof 76 as well as
various chemicals (such as pesticides containing
dichlorophenol). 77
The foods that most com
monly cause allergic reactions
are nuts (tree nuts), milk products, cereal products,
egg, fish and shellfish, as well as peanut, soy and other
legumes. Together they represent 90 percent of all
food allergens. Food allergies are often found during
childhood and they may disappear w
ith age. Allergic
reactions to food are usually quick and intense
compared to hypersensitivity reactions w
hich involve
symptom
s that are milder and m
ore varied. 78
Typical allerg
ic reactions
to food includ
e:
• Nettle rash
• Itchy skin
• Difficulties sw
allowing
• Runny or blocked nose
• Sneezing
• Nausea and vom
iting
• Abdom
inal pain
Sold to Fred Block Block (#GJ57M
BGL)
43
The causes of food-related
hypersensitivity reactions are: 79
• Digestive m
alabsorption
• General digestive disorders
• Increased gut permeability
• Imm
unological reactions (imm
unoglobulins)
• Toxins (additives and natural compounds) 80
• Psychological reactions
Food hypersensitivity may also be caused by the
histamine, tyram
ine or other biogenic amine present
in the food (chocolate, red wine, tuna or ferm
ented
ingredients such as cheese). In some cases, food (for
example tom
ato or pineapple) may release histam
ine
in the body. This is referred to as Histam
ine Intolerance
Syndrome (H
IS). 81 Individuals with H
IS typically have
a low level of diam
ine oxidase, an enzyme that
metabolizes histam
ine in the system. 82
This is something to consider if tests do not show
a
clear root cause but the individual still suffers from
symptom
s. Typically histamine increases the heart
rate and causes nasal congestion and flushing.
Histam
ine may also cause intestinal sym
ptoms such as
diarrhea and abdominal pain, as w
ell as neurological
symptom
s such as dizziness and headaches. Tyramine
may trigger a m
igraine attack. 83 Intense histamine
reactions may be prevented w
ith antihistamines or
enzyme preparations containing diam
ine oxidase.
ALLERG
IC REA
CTIO
N
Allergen
Initial contact w
ith allergen
B cell
Plasma cell
Released lgE antibodiesM
ast cell
lgE -reseptori
Allergen
Subsequent contact w
ith allergen
Granule H
istamine and
other chemicals
Allergic reaction
Sold to Fred Block Block (#GJ57M
BGL)
44
Foods rich in histam
ine or other vasoactive amines:
• Wine, alcoholic cider, beer and other ferm
ented
alcoholic drinks
• Fermented foods (sauerkraut, w
ine vinegar, soy sauce,
kefir, yogurt, kom
bucha)
• Aged cheeses
• Processed meat products (sausage, ham
, salami,
bacon)
• Smoked anim
al products
• Dried fruit
• Nuts (w
alnut, cashew, peanut)
• Yeast (promotes histam
ine production in food)
• Products made from
wheat
• Eggplant, spinach and tomato
• Certain types of fish such as m
ackerel, tuna,
anchovies and sardines
Foods that release histam
ine in the system:
• Banana
• Chocolate and cocoa
• Cow
’s milk
• Papaya
• Pineapple
• Citrus fruits
• Strawberry
• Nuts
• Tomato
• Spinach
• Pork
• Egg white (raw
)
• Food additives
Diam
ine oxidase b
lockers:
• Alcohol
• Black tea
• Energy drinks
• Green tea
• Yerba maté
NH
2
HN N
Sold to Fred Block Block (#GJ57M
BGL)
45
ToxinsM
any foods contain useful compounds such as
vitamins, m
inerals, trace elements and fatty acids, but
also unnecessary or harmful com
pounds, i.e. toxins.
Whether or not they cause sym
ptoms depends on the
nature of the toxin, the toxin levels in the plant eaten
and the individual's sensitivity to various substances.
Proper processing methods can often reduce the
level of harmful substances. For exam
ple, the false
morel m
ushroom contains gyrom
itrin, a
hazardous cytotoxin; but gyromitrin is
water-soluble and can be rem
oved by
blanching. Thus, it is possible to avoid
naturally-occurring toxins in food by
selecting and processing it properly.
Pesticides are used in the food produc-
tion industry to prevent plant diseases,
to control the effects of pests such as
weeds, insects and m
ites, and to
regulate growth.
Toxins that have adverse effects
on the bod
y include:
• Heavy m
etals
• Dioxins and PC
B com
pounds
• Organotin com
pounds such as PVC
• Microplastics
• Volatile organic compound (VO
C) em
issions
• Radioactive compounds
• Mycotoxins
• Carcinogens
• Xenoestrogens which im
itate
the effects of estrogen
• Antinutrients
• Certain pesticides
• Certain fertilizers
• Residues of medicinal products
• Other harm
ful organic
compounds
Sold to Fred Block Block (#GJ57M
BGL)
46
XE
NO
ESTR
OG
EN
S
Xenoestrogens imitate the effects of estrogen in the
body. They can be synthetic or naturally-occurring
compounds. Typical sources of xenoestrogens are
plastic bottles and containers, hygiene products and
cosmetics, teflon pans, shop receipts and canned food.
For example polycarbonate (PC
) plastic may release
bisphenol A (B
PA) w
hich has been associated with
endocrine disorders and a weakened im
mune
system. 84 B
PA and phthalates have epigenetic
effects (activating certain genes). 85 One can cut
their consumption of these w
ith smart choices
86
for example by discontinuing the use of plastic
water bottles. 87
Products containing xenoestrogens: 88
• Intensively farmed m
eat
• Canned food
• Plastics and plastic cling film
• Styrofoam cups and containers
• Pesticides
• Paints, varnishes and solvents
• Many hygiene products
• Phytoestrogens (estrogens derived from plants)
• Synthetic fragrances
• Contraceptive pills and sperm
icides
• Cosm
etics (including hair dyes)
• Detergents
• Air fresheners
Sold to Fred Block Block (#GJ57M
BGL)
47
AN
TINU
TRIE
NTS
Antinutrients are natural or synthetic com
pounds
that prevent nutrients from being absorbed, and m
ay
cause health problems. It is therefore useful to know
which foods contain them
and how food can be
processed to minim
ize their harmful effects.
Antinutrients are often found in plant roots and seeds,
nuts, legumes and nightshades. A
ll plants have protec-
tive mechanism
s. The purpose of antinutrients is to
protect the plant from external factors such as bacteria,
molds, insects and pests. Indeed, it m
akes sense for
the protective measures of plants to also cause
intestinal problems.
LectinsLectins are carbohydrate-binding proteins that appear
in plants and animals. Lectins protect plants from
various micro-organism
s such as insects and pests. 89
The roots and seeds of plants are particularly rich in
lectins. 90 Foods containing lectins include legumes
(beans, peas, lentils, soybeans, peanuts), cereals
(according to animal studies, w
heat germ agglutinin or
WG
A m
ight be particularly harmful to health), 91 92 pota-
toes, nuts and seeds.
Lectins have the ability to bind with the surface cells
of the digestive tract. This may cause increased gut
permeability and disruptions in digestion. 93 Raw
kidney
beans are particularly toxic. They contain high levels of
KERNEL C
OM
POSITIO
N
Sold to Fred Block Block (#GJ57M
BGL)
48
hemagglutinin, a substance that has the ability to cause
red blood cells to agglutinate.
It has been suggested that a link exists between lectins
and some autoim
mune diseases such as rheum
atoid
arthritis. 94 According to one research hypothesis, lectins
may cause leptin resistance (cf. insulin resistance) that
may contribute to the developm
ent of obesity and
metabolic disorders. 95
PhytatesPhytic acid is present in plants in salt form
, i.e. phytates.
Phytic acid can be found in the seeds of cereals and
legumes as w
ell as nuts. Phytic acid forms chelates w
ith
zinc, manganese, copper, iron and m
agnesium and m
ay
therefore impair the absorption of these m
inerals. 96
Typically the bacterial strain of the intestine contains
few phytase enzym
es which are able to break dow
n
phytates.
Cyanog
enic glycosid
esC
yanogenic glycosides consist of a sugar molecule
bound to a cyano group via a glycosidic bond. They
are so-called phytotoxins which function as a part of
the plant's defense system. Edible plants that contain
significant amounts of these com
pounds include
cassava and sorghum. Phytotoxins can also be found
in bamboo shoots, alm
onds, and the seeds of plums,
cherries, peaches and apricots. 97
Oxalates
Oxalates are com
pounds consisting of oxalic acid
and anions, salts or esters. Oxalic acid is a poisonous
substance that may dam
age the intestinal wall and
cause kidney stones by forming calcium
oxalate
crystals. 98 Plants rich in oxalate include spinach, parsley,
wood sorrel 99 and rhubarb as w
ell as beetroot, black
pepper, cocoa beans, cereals, legumes (particularly
soybeans) and nuts. 100
Sold to Fred Block Block (#GJ57M
BGL)
49
Saponins
Saponins are glycosides consisting of steroids
and triterpenes. They were nam
ed after their ability
to form soap-like foam
y structures in solutions.
They are an essential part of the plant's defense
system. 101 Saponins are found in vegetables such
as soybeans, beans, peas, as well as quinoa, oats,
asparagus, licorice root, sunflower seeds and
ginseng.
Saponins have several beneficial effects (including
anti-carcinogenic and imm
une system stim
ulat-
ing). 102 On the other hand, saponins have harm
ful
digestive effects (impaired absorption of proteins
and minerals, particularly in the case of soybeans) 103
and hypoglycemic effects (sharp drop in blood
sugar).
Glycoalkaloid
sG
lycoalkaloids are organic compounds bound w
ith
various sugar groups. They are naturally-occurring
poisons in certain plants and their purpose is to
protect these plants from anim
als. Nightshades
generally contain various amounts of glycoalkaloids.
A typical exam
ple is the solanine found in potatoes.
It is poisonous when ingested raw
in large quantities
(breaks down cell m
embranes
104 and inhibits
cholinesterase, i.e. the functioning of substances that
break down acetylcholine, etc.). Potato skins m
ay
cause intestinal damage, particularly w
hen fried
and consumed regularly for long periods of tim
e. 105
Raw green tom
atoes also contain high levels of
glycoalkaloids (tomatine). 106
Prolamins
Prolamins are nitrogen-storing proteins found in
cereals. Prolamins are rich in glutam
ine and proline
(amino acids). They include gliadin (a part of the w
heat
Sold to Fred Block Block (#GJ57M
BGL)
50
gluten protein), hordein (barley), secalin (rye), avenin
(oat) and zein (corn). The core parts of oats and rice
grains contain relatively low levels of prolam
in.
Prolamins cause intestinal dam
age particularly in
individuals suffering from celiac disease. C
eliac disease
involves gliadin attaching itself onto the surface of the
epithelial cells in the intestine and releasing zonulin
which causes gut perm
eability by damaging the tight
junctions between the epithelial cells. 107 In healthy
individuals, the effect of gliadin on gut permeability
is lesser although perceptible. 108
Goitrog
ensG
oitrogens are substances that interfere with the
iodine storage process of the body. Goitrogens include
soybeans, 109 pine nuts, peanuts, linseeds, spinach,
peaches, strawberries, and plants of the B
rassica genus
such as broccoli, Brussels sprouts, cauliflow
er, radishes,
kale and Chinese cabbage, as w
ell as rapeseeds and
horseradishes. 110
More so than food, the m
ain cause of the goitrogenic
effect in the body is due to goitrogens such as heavy
metals, insecticides, dioxin, PC
B, and several m
edicines
such as NSA
IDs and cholesterol m
edicines. 111
Phytoestrogens
Phytoestrogens are plant-derived xenoestrogens
(substances that imitate estrogen) that affect the
functions of the endocrine system. The highest level
of phytoestrogen in food is found in soybeans. Other
sources include legumes, alfalfa, vegetable oils
(rapeseed/canola and sunflower), cereal products
and processed meat products. 112
Phytoestrogens bind to estrogen receptors113 and thus
may interfere for exam
ple with the fem
ale menstrual
cycle. It is recomm
ended that pregnant wom
en or
those trying to become pregnant avoid phytoestrogens
due to their estrogenic effects. The use of soy-based
infant formula is also not recom
mended. 114
Sold to Fred Block Block (#GJ57M
BGL)
51
Phytoestrogens were previously believed to have an
effect on male fertility and testosterone levels.
How
ever, a meta-analysis study on the subject
published in 2010 did not indicate negative or
positive effects on fertility or testosterone levels
in the blood. 115
Enzyme inhib
itorsEnzym
e inhibitors are molecules that occur naturally
in some plants. They interfere w
ith the function of
various digestive enzymes. For exam
ple, protease
inhibitors that inhibit the function of trypsin and pepsin
can be found in raw soybeans. 116 A
mylase inhibitors,
high levels of which are found in kidney beans, are
another example of enzym
e inhibitors. Am
ylase
inhibitors interfere with the breakdow
n and absorption
processes of starch and other complex carbohydrates
in the digestive system. 117
Method
s of reducing
antinutrients
118 119 120
• Sprouting
• Soaking (adding lactic acid bacteria, diluted
hydrogen peroxide, iodine, vinegar or baking soda to
the soaking w
ater may boost the soaking process,
e.g. for rem
oval of phytates)
• Boiling
or blanching
(reduces oxalate levels, etc.)
• Cooking
(significantly reduces lectin and oxalate
levels)
• Lactic acid ferm
entation (significantly reduces
phytotoxins in cassava and phytic acid in cereal
products)
It is recomm
ended to combine several m
ethods to
achieve the desired effect. 121 The condition of the
intestinal mucous m
embranes m
ay be improved by
using lactic acid bacteria, 122 colostrum, 123 glutam
ine124
and silica. 125
Sold to Fred Block Block (#GJ57M
BGL)
52
REDU
CIN
G PH
YTATE LEVELS USIN
G VA
RIOU
S METH
OD
SProcess ofquinoa preparation
Cooking
(25 minutes, 100°C
/ 212°F)
Soaking
(12–14 hours, 20°C / 68°F)
and cooking
Fermenting w
ith whey
(16–18 hours, 20°C / 68°F)
and cooking
Sprouting
(30 hours, 30°C / 86°F),
soaking, lacto-fermenting
and cooking
Phytatereduction
15–20 %
69–77 %
83–88 %
97–98 %
Source: Reddy, N. R. et al. (2001). Food Phytates. C
RC Press.
Sold to Fred Block Block (#GJ57M
BGL)
53
FOD
MA
P CA
RB
OH
YD
RATE
S
The acronym FO
DM
AP is derived from
“Fermentable
Oligo-, D
i-, Mono-saccharides and Polyols”. In
practice it means carbohydrates that are particularly
suitable for fermentation by the bacteria in the colon.
Fermentation produces short-chain fatty acids (SC
FA)
that have significant health-promoting effects
126
(see section “Microbiom
e” for more details).
On the other hand, the ferm
entation process
forms gases in the intestine, potentially causing
bloating and flatulence. The FOD
MA
P carbo-
hydrate restrictions are particularly suitable for
individuals suffering from irritable bow
el syndrome
(IBS). 127 The recom
mended restriction for IB
S is
less than 10 grams per day. 128
EXAM
PLES OF FO
DM
AP FO
OD
S
Sold to Fred Block Block (#GJ57M
BGL)
56
The bacterial strain of the intestine
changes quickly whenever dietary adjustm
ents are
made. Studies on m
ice have found that upon changing
the diet, the microbiom
e may change overnight. Sim
ilar
changes also take place in humans but the exact tim
e
span is currently not known. 129 Sw
itching to a more
intestine-friendly diet has brought positive results in
the treatment of chronic inflam
mation, obesity and
gut permeability. 130
Gut perm
eability refers to the changed state of the epithe-
lial cells on the surface of the intestine. Norm
ally nutrients
are absorbed through the epithelial cells. How
ever, some-
times, the cells and the tight junctions betw
een them start
to “leak” and allow harm
ful substances into the circulation.
Celiac disease is a typical exam
ple of an autoimm
une
disease involving gut permeability. Increased gut perm
e-
ability (leaky gut syndrome) is one of the key factors in
the development of autoim
mune diseases. H
owever,
whether it is a cause or an effect is currently not know
n. 131
SO-C
ALLED
LEAKY G
UT
Sold to Fred Block Block (#GJ57M
BGL)
57
Ad
d these to sup
port the m
icrobiom
e:
• Fermentable fibers, i.e. prebiotics
132 133
– For exam
ple inulin, pectin and oligofructose
• Fermented foods (see section “Probiotics” for m
ore
details) 134 135
• Resistant starch136 137
– Found for exam
ple in green bananas, cooked and
subsequently refrigerated rice and potatoes as w
ell
as cereals
• Polyphenols138
• Dark chocolate (contains polyphenols and
ferm
entable fibers) 139
• Pistachios140
• Probiotics (certain bacterial strains, particularly
soil-based ones)
Avoid
these to protect the m
icrobiom
e
• Antibiotics (unless absolutely necessary for the
treatm
ent of illness) 141
• Pesticides containing glyphosate (including
Roundup) 142
– U
sed as a pesticide particularly on cereals,
genetically modified soybeans and corn
– M
eat from anim
als that have fed on the plants
mentioned above
– M
ay be one of the main factors contributing to the
development of celiac disease
143
• Smoking
144
• Alcohol 145
• Chronic stress
146
• Continuous negative thoughts and feelings
147 148
Sold to Fred Block Block (#GJ57M
BGL)
58
PRO
BIO
TICS
Probiotics refer to living microbes that have positive
effects on health. The benefits become apparent
through the balancing of the microbiom
e in the diges-
tive tract. Probiotic bacteria can be created in labora-
tory conditions or used as soil-based organisms (SB
O).
Probiotics have num
erous health benefits that have
been w
idely stud
ied in m
eta-analysis studies:
• Alleviating constipation
149
• May help in the treatm
ent of acute diarrhea150
• Preventing traveler's diarrhea (particularly
Saccharomyces B
oulardii) 151
• Facilitating the treatment of irritated bow
el
syndrome
152
• Stopping the progress of inflamm
atory intestinal
diseases, may facilitate recovery (particularly
Vivomixx probiotic) 153 154
• Facilitating recovery from non-alcoholic fatty liver
disease155
• May prevent a com
mon cold
156
• Preventing and treating diarrhea caused by antibiotics157
Probiotics availab
le from food
:
• Sauerkraut and other fermented vegetables
158
• Fermented vegetable juices
• Kefir
• Kombucha
• Kimchi
• Natto
• Tempeh
• Jun tea (fermented tea beverage)
RE
CO
MM
EN
DA
TIO
NProbiotics in the book’s bonus m
aterials:
biohack.to/nutrition
Sold to Fred Block Block (#GJ57M
BGL)
59
PRE
BIO
TICS
Prebiotics refer to indigestible fiber compounds such
as oligo- and polysaccharides used as a growth
medium
by the bacterial strain of the intestine. The use
of prebiotics promotes the grow
th of benign probiotic
bacteria such as bifidobacteria and lactic acid bacteria
in the intestine. The intake of prebiotics may have
positive effects on the absorption of trace elements, 159
the imm
une system, 160 blood pressure, and the
reduced risk of colon cancer. 161
Prebiotics availab
le from food
The table shows the foods richest in prebiotics. H
igh
levels of prebiotics can also be found for example in
potato starch which has been introduced in recent
years as a dietary supplement to support the bacterial
balance of the intestine. Potato starch is rich in
resistant starch which is beneficial to the m
icrobiome. 162
In addition to general prebiotic health benefits,
resistant starch has been shown to have beneficial
effects on insulin sensitivity and obesity as well as
hunger regulation both in rodents163 164 165 and
humans. 166 167 168 169
Inulin and oligofructose are prebiotics that promote
the well-being of the intestine. They also have health
benefits similar to those of dietary fiber.
The ratio of inulin to oligofructose per 100 g170
Chicory root
Jerusalem artichoke
Dandelion leaves
Garlic
Leek
Asparagus
Banana
41.6 g / 2.9 g
18 g / 1.5 g
13.5 g / 10.8 g
12.5 g / 5 g
6.5 g / 5.2 g
2.5 g / 2.5 g
0.5 g / 0.5 g
Sold to Fred Block Block (#GJ57M
BGL)
60
ME
THO
DS TH
AT SU
PPOR
T DIG
ESTIO
N
Review
eating hab
its• C
hew carefully
• Avoid stress at m
ealtimes
• Spend at least 20 minutes eating
• Avoid drinking liquids during m
eals
(dilutes stom
ach acids)
Review
foods that sup
port d
igestion
• Fresh carrot juice (supports intestinal mucous
m
embranes)
• Celery juice (prom
otes intestinal movem
ents and
alleviates constipation)
• Level of hydrochloric acid (betaine hydrochloride, HC
L)
• Carm
inatives reduce gas in the intestine:
– O
range, fennel, ginger, cinnamon, cardam
om, cilantro,
caraway, licorice, oregano, parsley, pepperm
int oil,
rosemary, sage, lem
on balm, dill, thym
e, garlic
• Bitters stim
ulate the production of stomach acids and
digestive enzym
es:
– Jerusalem
artichoke, Angelica sylvestris root, yellow
gentian, Angelica archangelica root
• Other foods that support digestion:
– A
loe vera, pineapple, chia seeds, chlorella, sauerkraut,
currants, Iceland moss, cham
omile, cranberries, oats,
meadow
sweet, blueberries, oregano, chaga m
ush-
rooms, papaya, linseeds, horse radishes, lingonberries,
psyllium, rhubarb root, plantago, rosehip, spirulina,
sea buckthorn, raspberry leaf, wheatgrass, valeriana
Review
dietary sup
plem
ents that supp
ort d
igestion
• Hydrochloric acid and pepsin
• L-glutamine:
– M
aintains the condition of the intestinal mucous
mem
brane
– Repairs gut perm
eability
• Silica and silicic acid-carmellose gel:
– Protects the m
ucous mem
brane of the stomach
• Magnesium
• Vitamin B
12
• Vitamins A
, D and E:
– Im
prove the regeneration of mucous m
embranes
• Phospholipids and lecithin:
– Prom
ote the absorption of fats
• Digestive enzym
es
Sold to Fred Block Block (#GJ57M
BGL)
62
Choosing a food
preparation method
carefully can have a significant effect on the quality
and absorbability of the resulting meal, as w
ell as the
amount of any harm
ful compounds in it.
No single preparation m
ethod is perfect. Some
ingredients are best eaten raw, w
hereas in many cases
proper preprocessing improves nutrient absorption
and significantly facilitates the function of the digestive
system.
A balanced m
ixed diet consists of both cooked and
fresh ingredients. The benefits and disadvantages of
cooking complem
ent each other when executed
properly.
Quality-m
inded food preparation methods im
prove
flavor, retain precious nutrients and reduce the amount
of harmful com
pounds formed w
hen the food is treated
in high temperatures.
Favor the follow
ing p
reparation m
ethods:
• Slow cooking
• Boiling
• Stewing
• Steaming
• Oven-baking slow
ly
• Sous-vide
• Raw food
• Fermentation
• Frying with w
ater
+
Sold to Fred Block Block (#GJ57M
BGL)
63
A
void the follow
ing p
reparation m
ethods:
• Frying at temperatures higher than 140 °C
(285 °F)
• Stewing in tinfoil
• Grilling
• Cooking in the m
icrowave oven
• Flambéing
• Smoking
• Deep frying
Harm
ful bacteria, viruses and parasite eggs are
destroyed during cooking. Heating also breaks dow
n
certain harmful com
pounds. For example, the oxalic
acid level in spinach is reduced when heated, and the
potentially carcinogenic compounds in cham
pignons
break down w
hen the mushroom
s are adequately
cooked.
Some nutrients are lost upon heating. For exam
ple,
many of the proven beneficial agents in broccoli are
destroyed when heated. 171 The levels of w
ater-soluble
Vitamins B
and C are reduced w
hen the ingredients are
boiled. Many m
inerals are also dissolved in cooking
water. Steam
ed food retains its nutrients significantly
better.
Cooking m
ay improve the absorption of certain
nutrients. The beta-carotene in carrots and lycopene
in tomatoes are absorbed m
ore efficiently once
cooked. 172 Only 4 %
of the beta-carotene in a raw
carrot is absorbed. Pureeing and cooking may
increase the absorption rate fivefold. On the other
hand, carotenoids may becom
e less beneficial when
cooked.
The Maillard reaction (brow
ning) improves the flavor
of food but impairs the absorption of proteins. 173
The reaction forms com
pounds that produce brown
color and flavors that are central to the color and taste
of many foods (M
RP compounds). The M
aillard reaction
starts at approximately 140 °C
(285 °F). The Maillard
reaction also produces carcinogenic compounds w
hen
the temperature exceeds 180 °C
(355 °F). 174
–
Sold to Fred Block Block (#GJ57M
BGL)
64
CO
OK
ING
AN
D H
AR
MFU
L C
OM
POU
ND
S
Harm
ful compounds form
in food at high temperatures.
These include glycotoxins (advanced glycation end-
products, AG
Es), heterocyclic amines (H
CA
s), polycyclic
aromatic hydrocarbons (PA
Hs) and acrylam
ide (AA
).
Food that contains high levels of cooking-induced
toxins is harmful because it increases oxidative stress,
raises the levels of inflamm
atory biomarkers and
weakens the arterial w
alls. 175 Thus it can increase the
risk of diabetes and cardiovascular diseases. 176
Cut the intake of glycotoxin-rich foods such as full fat
cheese, butter, bacon, sausage and processed meat.
Acrylam
ide, formed during the brow
ning of vegetables,
has a distinctive yellow or dark brow
n color. The toxins
formed w
hile frying fat and protein-rich foods are more
harmful than those form
ed while frying carbohydrate-
rich foods. 177
Instead of frying, consider boiling. For example, a
chicken breast fried for 8 minutes form
s more than 6
times the am
ount of harmful glycotoxins com
pared to
a chicken breast boiled for an hour. Temperature, not
cooking time, is key.
Tinfoil is typically used for stewing m
eat or fish on a
grill or in an oven. Stewing in tinfoil reduces the
formation of glycotoxins and H
CA
s, but the amount
of aluminum
released into the food is up to 6 times
the amount considered a safe daily upper lim
it. 178
Sold to Fred Block Block (#GJ57M
BGL)
65
MA
RIN
AD
ES
Throughout history, food has been marinated in herbs,
fats, citrus fruit, vinegar and alcoholic beverages such
as wine and beer to preserve the food and im
prove its
flavor. Studies have also found that marinades affect
the amount of harm
ful compounds form
ing in cooked
food.
Red
ucing harm
ful comp
ounds b
y marinad
ing:
• The amount of H
CA
s is reduced by up to 90 % w
hen
the m
eat is marinated for 4 hours or m
ore in alcoholic
beverages and strong spices such as garlic, ginger,
thym
e, rosemary and chili, 179 or w
hen food is
m
arinated for 6 hours or more in beer 180
• Cherries, blueberries, blackcurrants, plum
s and
kiw
ifruit used in marinades effectively reduce
the am
ount of HC
As
181
• Adding vitam
in E to the marinade reduces the
am
ount of HC
As
182
• Adding vitam
in C reduces the am
ount of
glycotoxins
183
• Adding turm
eric diminishes the effect of
glycotoxins
184
• Frying in extra virgin olive oil produces the least
H
CA
s compared to other oils such as rapeseed oil 185
• The amount of A
GEs can be reduced by using sour
ingredients such as lem
on juice and vinegar in the
m
arinade186
• The amount of potentially carcinogenic substances
can be reduced by adding glucose during brow
ning187
• The amount of acrylam
ide in potatoes can be
reduced by blanching them
before frying188
• Adding am
ino acids such as glycine and glutamine
to the dough before baking reduces the am
ount of
acrylam
ide by up to 90 %189
Sold to Fred Block Block (#GJ57M
BGL)
66
SOU
S-VID
E
With the sous-vide m
ethod, food is prepared under
water in a sealed vacuum
bag while m
aintaining careful
control over the temperature.
Benefits of the sous-vid
e method
:
• Close control of the tem
perature-induced changes
of ingredients
• Cooking tem
perature can be reduced
• Cooking tim
e can be increased
• Pathogens can be minim
ized through pasteurization
• Precooking extends the shelf life and makes cooking
quicker and easier
• Flavors, nutrients and liquids are retained better
(particularly in the case of vegetables such as
carrots) 190
Disad
vantages of the sous-vid
e method
:
• Sous-vide bags may release toxins
• Sous-vide bags are expensive and not ecological
To ensure safety, attention should be paid to the
recomm
ended cooking temperature and tim
e of the
chosen ingredient. As a rule of thum
b, cooking at a
minim
um of 55 °C
(131 °F) for an hour or more is usually
sufficient to destroy pathogens such as Listeria,
Salmonella, H
elicobacter pyroli and Trichinella.
Try comb
ining m
ustard seed
s and
broccoli in a sous-vid
e bag
.
Eating fresh, uncooked broccoli with
a meal reduces the m
utagenic effect
of HC
As. 191 This is thanks to broccoli’s
sulphur-rich compounds w
hich are
normally w
eakened upon cooking.
The effects of the compounds can be
retained when using sous-vide by
adding mustard seeds into the bag. 192
TIP
Sold to Fred Block Block (#GJ57M
BGL)
67
Food that has been properly precooked, rapidly cooled
and kept refrigerated in an unopened sous-vide bag
will usually keep for at least a w
eek, or several months if
frozen. Adding m
arinades or vitamins C
or E193 to the
sous-vide bag will extend the shelf life due to reduction
of the oxidation of ingredients. Favor bags that do not
contain BPA
s, phthalates or plasticizers. Bags m
ade out
of polyethylene or silicon are usually the safest.
DIY
sous-vide
If you are not yet ready to invest in a sous-vide cooker, you can
test the technique at home by using com
mon utensils. You just
need a thermom
eter, a cooler box and a watertight ziplock bag.
Place the food in the ziplock bag. Lower the bag into the w
ater
and squeeze the air out of the opening. Close the bag just
before the opening reaches the water surface. Fill the cooler
box with w
ater that is 2 degrees (35 °F) warm
er than the target
temperature. Low
er the bag into the water and close the lid.
Check the w
ater temperature every 20 m
inutes. If needed, add
warm
water to m
aintain the target temperature. A
fter a suffi-
cient cooking time, rem
ove the bag from the w
ater and enjoy.
RE
CIPE Sold to Fred Block Block (#G
J57MBG
L)
68
PRE
SERV
ING
In the course of history, a wide variety of m
ethods has
been used to preserve food. In recent decades the
food industry has made significant developm
ents in
food additives and preservatives as well as introducing
new processing m
ethods. In practical terms m
ost of us
preserve food in a refrigerator, freezer or pantry on a
regular basis. In addition to this, the lifespan of various
ingredients can be extended with sm
art choices of
storage material, correct preservation m
ethods and
high quality health-promoting preservatives.
Avoid using photodegradable m
aterials such as plastic
containers for preserving food. Favor ceramics, m
etal
and glass.
Recom
mend
ed ap
proaches to p
reservation:
• Protecting from light in dark or tinted containers
• Protecting from heat for exam
ple by utilizing a root
cellar or refrigerator
• Protecting from air in an airtight container or vacuum
bag
• Drying and freeze-drying
• Sterilizing at high temperatures
• Preventing oxidation with strong spices
• Preventing oxidation with vitam
ins C and E
• Preserving in a modified atm
osphere, honey, sugar,
alcohol, vinegar, lem
on juice, salt or oil
Sold to Fred Block Block (#GJ57M
BGL)
69
EN
SUR
ING
THE
SUFFIC
IEN
T IN
TAK
E O
F NU
TRIE
NTS
To a large extent, nutrient intake guidelines are based
on population-wide studies regarding the frequency
of deficiencies and certain illnesses caused by poor
nutrition. 194 How
ever, these guidelines do not necessarily
reflect an individual's optimal nutritional level w
hich
can vary considerably due to genetic and epigenetic
factors. Mutations are constantly taking place in
each one of us. These mutations can cause unique
differences in the DN
A sequence. 195
From the view
point of dietetics and nutrition, these dif-
ferences can alter the individual requirements of certain
trace elements and vitam
ins. In many cases, m
utations
directly affect the coenzyme function of vitam
ins and
trace elements (for exam
ple zinc, vitamin B
6 or choline)
and the requirements for these nutrients in the body. 196
Assessing the individual nutritional requirem
ents
should therefore always be the first priority for
designing dietary recomm
endations.
Dietary reference
values
Lower intake level
Averag
e
requirem
ent
Recom
mend
ed
intake
Op
timal intake
Description
The minim
um am
ount required
to prevent deficiency. Not
sufficient to maintain good
health and nutrition.
The nutrient amount that m
eets
the average requirements of
general population or a specific
population group.
The nutrient amount that m
eets
the nutritional needs of nearly all
healthy individuals.
The individual's current optimal
nutrient amount that helps to
achieve the best possible state
of health.
Sold to Fred Block Block (#GJ57M
BGL)
70
Nutrient levels depend greatly on unique absorption
rates. It is not possible to take this factor into account
when drafting general dietary guidelines. If the
digestive functions are not performing, nutrients
are not absorbed to the extent perhaps expected.
Optim
al nutrient intake should therefore begin by
improving digestive processes.
Bruce A
mes, an A
merican professor of biochem
istry
and molecular biology, has studied cancer and
aging over the course of several decades. According
to Am
es’ triage theory of micronutrients and aging,
the body uses the nutrient reserves of various internal
organs to maintain short-term
health in a state of
malnutrition. For exam
ple, in the event of iron
deficiency, the body uses the iron reserves of the
liver to maintain norm
al bodily functions. Long-term
deficiency of minerals and vitam
ins weakens the body
and causes DN
A and m
itochondrial damage. 197 This
may lead to cancer and the acceleration of aging.
Am
es’ recomm
endation for longevity is to meet the
micronutrient requirem
ents at all stages of life. 198
NU
TRIENT A
BSO
RPTION
Sold to Fred Block Block (#GJ57M
BGL)
71
Micronutrient
Iron
Vitam
in B12
Vitam
in D
Iodine
Frequency of deficiency
Particularly in developing
countries and some vegan
individuals. Celiac disease,
Crohn’s disease and pregnancy
are predisposing factors.
Particularly in vegans but
increasingly comm
on for
other diets as well.
Deficiency occurs particularly
in the northern hemisphere
where sunlight is scarce.
A serious public health problem
in the developing world, but
as much as approx. 40 %
of the
people in the world are at risk.
Availability from
food and other rem
arks
Blood, bovine liver, oysters,
mussels, beef, sardines, dark
green vegetables.
Vitamin C
promotes the
absorption of iron.
Bovine liver, sardines, salm
on,
eggs, soil.
The sun, fish, fish oil and
mushroom
s. Sufficient intake
from food alone is difficult.
Seaweed (particularly kelp/
kombu), seafood and egg yolk.
Impoverished soil is a predispos-
ing factor for iodine deficiency.
Health problem
s caused by deficiency
The most com
mon nutrient deficiency
in the world. C
auses anemia, suscep-
tibility to infections, respiratory prob-
lems, hair loss, m
uscular problems,
headaches, heart problems, fatigue, etc.
Causes pernicious anem
ia, fatigue,
dementia and depression. Increases
the risk of coronary artery disease
and osteoporosis.
Predisposing factor for osteopo-
rosis, infections, diabetes, cancer,
cardiovascular diseases and various
neurological diseases.
Predisposing factor for hypothy-
roidism and goitre. D
eficiency
during pregnancy predisposes the
child for cretinism.
The most com
mon m
icronutrient deficiencies and
their availability in food
Sold to Fred Block Block (#GJ57M
BGL)
72
Micronutrient
Selenium
Mag
nesium
Zinc
Vitam
in K2
Frequency of deficiency
Mild deficiency is com
mon.
Mild deficiency is very com
mon
around the world. M
agnesium
deficiency is particularly comm
on
in diabetic individuals.
Mild deficiency is relatively com
-
mon particularly in vegans and the
elderly. The low level of hydrochlo-
ric acid in the stomach is a predis-
posing factor for zinc deficiency.
“The forgotten vitamin.” A
large proportion of people are
deficient in vitamin K2. O
ne of
the leading causes for this defi-
ciency is the use of antibiotics.
Availability from
food and other rem
arks
Brazil nuts, w
ild salmon, kidneys,
mutton, egg yolk. Im
poverished
soil is a predisposing factor for
selenium deficiency.
Dark green vegetables, cocoa, nuts
and seeds. Regulates the function-
ing of more than 300 enzym
es in the
body. Impoverished soil is a predis-
posing factor for deficiency.
Insects, oysters, calf liver, beef,
pumpkin seeds, m
utton. Regu-
lates the functioning of more than
200 enzymes in the body.
Natto, m
iso, sauerkraut,
grass-fed butter, roe,
fermented foods in general.
Intestinal bacteria produce a
small am
ount of vitamin K2.
Health problem
s caused by deficiency
Increased risk of inflamm
atory dis-
eases, cardiovascular diseases and
cancer. Impaired im
mune response
and activation of thyroid hormones.
Predisposing factor for cardio-vas-
cular diseases, diabetes, hyper-
tension, fibromyalgia, osteoporo-
sis, constipation and stress.
Predisposing factor for poor
condition of skin, hair and nails,
weakened im
mune system
and
fertility problems.
Predisposing factor for tooth
decay, dental plaque, osteo-
porosis and artery calcification.
Sold to Fred Block Block (#GJ57M
BGL)
74
French chemist and physicist N
icholas
Clém
ent (1779–1841) introduced the concept of the
calorie in the early 1800’s. 199 Calorie is French and refers
to a unit of energy that raises the temperature of 1 kg
of water by one degree centigrade. The term
gained
popularity in measuring the energy content of food
at the beginning of the 20th century. 200 How
ever, the
official term kilojoule is used in nutrition research and
discourse as the unit of energy provided by food.
The importance of certain trace elem
ents such as
iron, iodine and zinc was realized as early as the 19th
century. In his research, French chemist Jean-B
aptiste
Boussingault (1801–1887) proved that iron is an essential
nutrient for human beings. Iodine deficiency w
as
understood to cause goiter and cretinism – conditions
in which the thyroid produces an insufficient am
ount of
thyroxine. In France, schoolchildren were given iodine
tablets to prevent goiter. In 1912, Cam
bridge University
scientist Frederick Hopkins (1861–1947) discovered that
in addition to macronutrients, hum
an beings need so-
called accessory factors to support the functions of the
body. 201 Later these nutritional factors became know
n
as vitamins.
The concept of micronutrients w
as introduced
in the 1930's in the context of trace elements
required by plants. Research on the
recomm
ended levels of micronutrient intake
and their significance for health began in the
1940's. According to com
prehensive studies,
micronutrient deficiencies w
ere very comm
on
in the industrialized countries. The proposed
solution to this problem included introducing fish
liver oil and modifying everyday food item
s (e.g.
adding iodine to salt). 202
The biohacker measures the functions of his/her
body in relation to nutrition to acquire information
about blood cells, vitamins, m
icro- and
macronutrient levels, the m
icrobiological status of the
intestine, special genetic traits and any food-related
hypersensitivities or allergies.
Measuring
the nutritional statusIt is w
ise to find out what your nutritional starting point
is before making any significant dietary changes or
investing in supplements. H
ave your nutrient levels and
key blood values measured. Even if you feel healthy,
getting tested may be beneficial for prevention.
Sold to Fred Block Block (#GJ57M
BGL)
75
• Levels of micronutrients and trace elem
ents
– From
blood
– From
hair
– From
urine
• Fatty acids
– From
blood
• Am
ino acids
– From
blood
• Heavy m
etals
– From
blood
– From
hair
Testing for food
allergies and
hyp
ersensitivitiesIdentifying the foods that are harm
ful or detrimental
to the function of the body is particularly important.
Eliminating these m
akes for significantly better physical
and psychological performance and, above all,
improved overall health.
Testing for food
allergies:
• Trial elimination diet
• Skin prick test
• IgE and lgG antibody tests
• Open food challenge (m
ilk and cereals)
Analyzing
the intestinal function and the
microb
iome
The intestinal function and bacterial balance of an
individual can change very rapidly. These changes are
linked to several illnesses that could be prevented or
treated effectively by analyzing the functionality and
microbiological balance of the intestine. Physical and
psychological performance is also strongly linked to
the condition of the intestine.
Dig
estion analyses:
• Com
prehensive digestion analysis
• Measuring gut perm
eability and malabsorption
• Measuring the possible sm
all intestinal bacterial
overgrow
th (SIBO
)
• Measuring stom
ach acid and enzymes
• Testing for Helicobacter pylori
Microb
iome analysis:
Helpful bacterial strain
• Harm
ful bacterial strain
• Yeast fungi
• Am
oebas and other parasites
Sold to Fred Block Block (#GJ57M
BGL)
76
GE
NE
TESTS
Gene tests can be used to identify increased individual
risks of various illnesses which are then taken into
account when m
aking lifestyle choices. It is important
to understand that your lifestyle (including your diet)
controls the function of your genes. Not all genes are
constantly active. Epigenetics (the activation or deacti-
vation of genes by factors external to the genome)
can be perceived for example in the increased or
decreased function of certain genes due to environ-
mental factors such as diet.
Nutrigenom
ics involves the study of the effects of nutri-
tion on the function of genes. For example, researchers
at the Norw
egian University of Science and Technology
(NTN
U) have found that cutting sugar consum
ption (to
less than 40 percent of the energy content of the meal)
can lower the risk of cardiovascular diseases, dem
entia,
some types of cancer and diabetes. 203 G
enes affect
metabolism
in a comprehensive w
ay. Because of this,
it would be a m
istake to expect that a particular diet
(such as a low-fat or low
-carbohydrate diet) would
produce the same results for everyone.
Listed b
elow are som
e gene variants that are
worth noting
in terms of d
iet:
Variant APO
E4 of the APO
E gene
• Apolipoprotein E (A
POE) is crucial for fat
m
etabolism, particularly for breaking dow
n
lipoproteins (including LD
L).
• Types 3/4 and especially 4/4 are associated with
high cholesterol levels, carotid artery disease and
A
lzheimer's disease. 204
• Although the cognitive processes of
individuals w
ith a type 4 variant deteriorate
faster than usual, their brain function early
in life is enhanced, particularly in the
hippocam
pus. 205
Variant Pro12Ala of the PPA
RG
2 gene
• PPARG
(Peroxisome Proliferator-activated
Receptor G
amm
a) is a nuclear protein
that has an effect on obesity.
• The Ala type is associated w
ith a
low
ered risk of developing type
2 diabetes. 206
Sold to Fred Block Block (#GJ57M
BGL)
77
• How
ever, a study conducted on mice found that for
individuals w
ith this variant, a high-fat diet increased
obesity m
ore rapidly and thus formed a predisposing
factor for diabetes. 207
Variants IVS4G
>T and
IVS3C
>T of the TC
F7L2 gene
• TCF7L2 is a protein transcription factor.
• These variants are associated with an increased risk of
developing type 2 diabetes. 208
Variant Trp64A
rg209 of the B
3AR
gene and
variant Gln27G
lu210 of the B
2AR
gene
• Beta-adrenergic receptors have a significant effect
on energy production and the function of the
sym
pathetic nervous system.
• These variants are associated with obesity.
Variant rs9939609(A) of the FTO
gene
• FTO =
fat mass and obesity-associated protein
• Individuals with a type A
variant have a significantly
increased risk of obesity and developing type 2
diabetes. 211 212
Variant rs4988235 of the MC
M6 g
ene
• Affects the production of the lactase enzym
e (LCT).
• Individuals with a T type variant usually tolerate
lactose.
• The C/T type variant is associated w
ith obesity. 213
• Individuals with a C
/C type variant are likely to be
lactose intolerant. 214
Variants HLA
-DQ
2 and HLA
-DQ
8 of the HLA
-DQ
gene
• HLA
-DQ
genes encode certain proteins as a part of
the im
mune system
.
• These variants are strongly associated with celiac
disease. 215
Variant A118G
of the OPR
M1 g
ene
• The OPRM
1 gene encodes opioid receptors.
• The type G variant can significantly increase alcohol
dependency
216
Variant I148M of the PN
PLA3 g
ene
• This variant of the PNPLA
3 gene related to fat
m
etabolism slow
s the breakdown of triglyceride fats
in the liver and thus prom
otes the onset of fatty liver
disease. 217
Sold to Fred Block Block (#GJ57M
BGL)
78
Variant 164A>
C of the C
YP1A
2 gene
• Caffeine, m
ycotoxin and paracetamol (am
ong
others) are broken dow
n in the liver mainly by the
C
YP1A2 enzym
e.
• Each individual's CYP1A
2 enzyme system
functions at
a different rate.
• Individuals with a type C
variant have a slow enzym
e
system
. For these individuals, drinking coffee can
increase the risk of heart attack214 and/or high blood
pressure. 219
Variants C677T and
A1298C
of the MTH
FR g
ene
and variant A
66G of the M
TRR
gene
• Methylene tetrahydrofolate reductase (M
THFR) is
an enzym
e needed to convert folic acid and certain
other form
s of folate into methylfolate (5-M
THF).
Folic acid can be found in vitam
in supplements and
vitam
in-enriched foods.
• Individuals with these variants are unable to efficiently
convert folic acid into active folate. This results in
a high hom
ocysteine level, a known risk factor for
cardiovascular diseases, particularly in individuals w
ith
variants C
677T and A66G
. 220
• Switching from
folic acid to more efficient m
ethyl-
folate is recom
mended.
Variant A1 (Taq
1A p
olymorp
hism) of the A
NK
K1
gene
221
• AN
KK1 (ankyrin repeat and kinase domain containing
1) is fundam
entally linked to the dopamine D
2
receptor (D
RD2), i.e. rew
ard and motivation.
• A m
utation in this gene is a predisposing factor for
addictive behavior (alcohol, tobacco, sugar,
gam
bling, opiates). 222
• The A1 allele is especially found in obese (B
MI >
30)
individuals. 223
Variant rs1229984 of the AD
H1B
gene
• Accelerates the conversion of alcohol into
acetaldehyde (a m
ore rapidly developing hangover).
• Individuals with this variant have a
low
ered risk of developing alcoholism. 224
Mutation of the A
LDH
2 gene in
isoenzyme A
LDH
2-2
• Significantly lowered isoenzym
e ALD
H2-2
activity (typically found in N
orth Asia).
• A predisposing factor for adverse effects
from
alcohol and alcohol poisoning. 225
Sold to Fred Block Block (#GJ57M
BGL)
80
“Everything should b
e m
ade as sim
ple as possible, but not sim
pler.” – A
lbert Einstein (1879–1955)
Sold to Fred Block Block (#GJ57M
BGL)
81
Dietary changes should be im
plemented
with care. For instance, studies indicate that current,
popular extreme diets can lead to m
icronutrient defi-
ciencies. 226 On the other hand, ordinary hom
e-cooked
food may not fulfill dietary guidelines, either.
In this chapter we give guidelines for better, m
ore
nutrient-rich choices for individual ingredients. Low
quality ingredients are relatively easy to rule out by
applying a few core principles. To paraphrase
Michael Pollan, the Knight Professor of Science and
Environmental Journalism
at UC
Berkeley: “D
o not buy
anything your grandmother w
ould not have recognized
as food 50 years ago.” This quickly eliminates
convenience foods and the lowest quality products.
The rule of thumb is that the closer the food is to
its original state, the more likely it is to have health-
promoting properties. M
eta-analyses have found that
organically produced ingredients contain significantly
more antioxidants and less heavy m
etals and pesticides
than non-organic ingredients. 227
IND
IVID
UA
LITY
NU
TRIEN
TD
ENSITY
QU
ALITY
Sold to Fred Block Block (#GJ57M
BGL)
82
BIO
HA
CKER´S KITC
HEN
Herb garden
Extensive spice rack
Titanium frying pan
Berries and gam
ein the freezer
Water filter
Dark glass bottles
Powerful blender
Plenty of vegetables in the refrigerator
Coffee grinder
Boiler
SousVide-cooker
Accessible utensils
Induction cookerEnergy-efficient refrigerator
Sold to Fred Block Block (#GJ57M
BGL)
83
SALT
In the Mediterranean countries, salt w
as once
considered as valuable as gold. Soldiers of the Roman
legion were partially paid in salt. It w
as referred to as
salarium argentum
, “salt money”. This is also w
here the
English term “salary” originates from
. The Latin word
“sal” is also thought to be the origin of the Roman
word “salute,” w
hich in turn is associated with the
Arabic “salaam
,” meaning “peace.”
The global average salt intake in 2010 was around 10
grams per person per day. A
round 80 % of total salt
intake is so-called hidden salt that can be found in
several processed foods (such as grain and meat
products). For example bread can have as m
uch
salt as potato chips.
Cutting the consum
ption of table salt and hidden salt is
generally recomm
ended, as is using mineral salt w
hich
is rich in potassium and m
agnesium. Favoring m
ineral
salt makes it possible to low
er blood pressure without
cutting salt consumption. 228 It should be noted that
Sold to Fred Block Block (#GJ57M
BGL)
84
although excessive intake of salt is strongly associated
with high blood pressure, insufficient salt intake is a
health risk that is even more serious. 229
High quality salt enhances flavors, preserves food and
maintains the fluid balance of the body. Sodium
is
essential to the body for carrying nerve impulses,
maintaining m
uscle function and regulating fluid
balance and blood pressure. Chloride is needed for
digestion and respiration.
Natural salts are produced either by evaporating sea-
water or by m
ining ancient sea sediments. Favor coarse
salt crystals and grind them at hom
e using a salt mill.
Consider the possible risk of heavy m
etals (including
nickel) or plastic particles from poor quality salt m
ills
contaminating the salt. The quality of the salt also
depends on the cleanliness of the sea and the area in
which the salt is handled.
Several countries add iodine to table salt to address
the iodine deficiency problem. H
owever, salt is not the
best source of iodine. For example, one teaspoon of
kelp provides as much iodine as one pound of iodine-
enriched sea salt.
Favor:
• Purity-tested, unrefined sea salts
• Mineral salts
• Pink salts sold under various names (H
imalayan salt,
rose salt, rock salt, halite)
• Black salts
• Herbam
are seasoning
• Rare specialty salts (bamboo salt, river salt)
A
void:
• Com
mon refined salt and table salt
• Seasoned salt (with m
onosodium glutam
ate, MSG
)
Mix tog
ether several different typ
es
of salt and dried herbs (such as rose-
mary, basil and m
int), if desired. This
increases the nutritional density and
aromas of the salt used.
TIP
– +
Sold to Fred Block Block (#GJ57M
BGL)
85
SUG
AR
In the United States, the average person consum
es
more than 126 gram
s of sugar per day. That is more
than twice the recom
mendation for daily intake by the
World H
ealth Organisation. A
round 70–80 % of this
sugar is so-called hidden sugar. It is plentiful in many
processed foods such as yogurt, juice, soda, cold cuts,
pizza, soy sauce, mayonnaise and m
any convenience
foods.
Com
pared to cane sugar, white refined sugar contains
no trace elements or m
inerals. White refined sugar can
interfere with the absorption of calcium
, magnesium
,
zinc and iron. It also consumes the body’s supplies
of trace elements and m
inerals, as sugar metabolism
requires several different trace elements.
The excessive use of white sugar is associated w
ith
numerous m
etabolic disorders such as type 2
diabetes and metabolic syndrom
e, 230 disrupted fat
metabolism
and systemic inflam
mation, cardiovascular
diseases231 232 233 and A
lzheimer’s disease. 234 235 In
addition, sugar and fructose strain the live. 236 What is
worse, studies have found that sugar causes physical
dependence. 237
We recom
mend replacing w
hite sugar with alternatives
that contain trace elements, and avoiding sources of
hidden sugar such as flavored yogurt, juice, soda and
convenience foods.
Honey
Favor:
• Unheated and unfiltered
• Unprocessed local honey, produced in
an unpolluted area and collected from
a single farm
• Varietal honey (for example buckw
heat,
m
anuka, tualang)
• The darker the color, the better
+
Sold to Fred Block Block (#GJ57M
BGL)
86
The lower age lim
it for honey consumption is generally
12 months because of the higher risk of infants devel-
oping botulism caused by C
lostridium botulinum
due
to underdeveloped intestinal flora. Honey has yielded
good results in the treatment of acute coughing in
children238 239 as w
ell as in allergy desensitization
therapy.
Crystallized
sugars
Favor:
• Coconut sugar
• Whole cane sugar (unrefined and processed as little
as possible, often sold under m
ore unusual names
such as Indian, rapadura, kokuto or m
ascobado
sugar).
A
void:
• Bleached sugar
• Brow
n sugar (partially bleached raw cane sugar, also
sold under m
ore unusual names such as m
uscovado,
dem
erara or molasses sugar)
• Baking sugar (including icing sugar, soft brow
n sugar,
vanillin sugar)
• Fructose
Herb
honey
Mix genuine vanilla, spirulina or for
example nettle seeds in honey. H
oney is
a wonderful preservative and the spices
or herbs mixed in it give a nice touch to
its flavor. RE
CIPE
+–
Sold to Fred Block Block (#GJ57M
BGL)
87
Hig
h intensity sweeteners
and sug
ar alcohols
Favor:
• Birch-based xylitol
• Green stevia (leaves of the w
hole plant)
A
void:
• GM
O xylitol
• Erythritol
• Sorbitol
• Steviol glycoside extracts (white stevia)
• Aspartam
e
• Acesulfam
e K
Syrups
Favor:
• Maple syrup
• Coconut syrup
• Yacón syrup
• Kitul palm (caryota urens) syrup
• Spruce tip syrup
A
void:
• Fructose-glucose syrup (corn syrup)
• Agave, sugar syrup, flavor syrups
Other
Use as sw
eetener when need
ed:
• Luo han guo (monk fruit)
• Lucuma
• Nopal cactus (prickly pear)
• Inulin
• Licorice root
+–
+–
Sold to Fred Block Block (#GJ57M
BGL)
88
SPICE
S
Spices are used to add flavor and preserve food.
Spices can be strongly flavored or aromatic plant parts,
components extracted from
plants, or minerals.
Many spices and herbs have both health-prom
oting
and illness-preventing qualities. Several spices also
stimulate the function of digestive system
.
Flavor and scent are sourced from the oxidizing and
vaporizing plant parts. Therefore, ground spices
gradually lose their flavor and any medicinal effects.
Whole spices keep for approxim
ately two years,
whereas ground spices keep for six m
onths or so;
however, the flavor m
ay suffer much sooner.
Favor:
• Wild vegetables and w
ild spices
• Fresh ginger and turmeric
• Garlic and onions
• Chili, cayenne and black pepper
• Ceylon cinnam
on, cardamom
, caraway, fennel and
bay leaves
• Rosemary, oregano, thym
e, dill, tarragon, coriander,
m
int, basil, parsley and sage
• Maintaining your ow
n miniature herb garden near a
w
indow or on a balcony
• Purchasing organic spices whole (not ground)
A
void:
• Highly irradiated spices
• Expired spice shakers that have been constantly
exposed to light, heat and m
oisture
+–
Sold to Fred Block Block (#GJ57M
BGL)
89
• Many spices such as peppers can easily go m
oldy if
handled directly over the cooktop
Coum
arin is an aromatic com
pound found naturally
in many plants. Its m
ain source in food is cinnamon.
In Europe and the United States, C
hinese cassia
(cinnamom
um cassia) is the m
ost comm
on type of
cinnamon used, and it contains large quantities of
coumarin. The rare, m
ore expensive Ceylon cinnam
on
(cinnamom
um zeylanicum
) contains very little coumarin.
Coum
arin is toxic to the liver (hepatotoxic), although to
reach the toxicity level one would have to regularly
consume m
ore than two tablespoonfuls daily. In 2004
the European Food Safety Authority (EFSA
) set a
tolerable daily intake for coumarin at 0.1 m
g per
one kilo of body weight per day. The regular liberal
use of cinnamon is not recom
mended.
Alzheim
er’s disease is most com
mon in W
estern Eu-
rope, and North A
merica is close behind. The use of
turmeric m
ight provide some protection against neuro-
logical disorders. 240 It may also have a positive im
pact
on several inflamm
atory illnesses such as arthritis241 242
and ulcerative colitis. 243 Turmeric also has antibacterial,
antiviral and antifungal properties in humans. 244 It m
ay
also have a cancer preventive effect. 245 246
Sold to Fred Block Block (#GJ57M
BGL)
90
AN
IMA
L PRO
DU
CTS
When consum
ing animal products, favor quality over
quantity. Eat a wide variety of anim
als and their parts.
Using the entire anim
al for food by “eating from nose
to tail” provides a wide variety of nutrients, for instance
in the form of bone broth and offal. Favor intelligent
preparation methods that enhance flavor and nutrient
absorption as well as reduce the am
ount of harmful
compounds. U
se more spices and not just for garnish.
This promotes digestion and provides the system
with
anti-inflamm
atory compounds.
Meat
The consumption of m
eat is a divisive topic. The
consumption of intensively farm
ed meat has been
linked to various illnesses in numerous studies. O
n the
other hand, high quality animal products can be one of
the most nutrient dense elem
ents of a diet. The higher
you are in the food chain, the more the links below
affect the quality and nutrient density of your food.
The animal’s genetics, environm
ent, diet, freedom
of movem
ent, quality of drinking water, veterinary
medicines used and m
any other factors have a signifi-
cant impact on the fatty acid com
position of the meat,
the amount of nutrients or possible harm
ful substances
in it and the effect the food has on the body.
Meat products have different health im
pacts depend-
ing on the animal and the farm
ing method used. The
liberal consumption of highly processed m
eat may
increase the risk of bowel cancer, 247 type 2 diabetes, 248
stroke, 249 esophageal cancer 250 and gastric cancer. 251
The demographic group that consum
es the most
processed meat products has a higher m
ortality rate
than the group that consumes the least. 252 The risks
vary depending on the animal species. For instance,
compared to beef, bison m
eat, has not been found to
cause an increase in low-grade inflam
mation. 253 254 In
addition, the meat from
grass-fed animals has a better
fatty acid composition and contains m
ore antioxidants
than intensively farmed m
eat.
Unbalanced anim
al consumption (for instance, only
favoring muscle m
eat) can cause an amino acid
imbalance in the body. M
uscle tissue is rich in
methionine, the excessive consum
ption of which has
been found in animal tests to increase oxidative stress
and to accelerate aging. 255 256 257 Muscle tissue is scant
in glycine, an essential amino acid that is plentiful in
Sold to Fred Block Block (#GJ57M
BGL)
91
collagen-rich animal parts. These include connective
tissue, bone marrow
and skin. Some connective tissue
containing glycine can also be found in minced m
eat.
The harmfulness of m
ethionine may w
ell be related to
the lack of glycine in our diets. In animal tests, glycine
has been found to have lifespan-extending qualities258
and similar effects are probable in hum
ans. 259
The preparation method used for the m
eat is of utmost
importance. In addition to harm
ful AG
E and PAH
com-
pounds (see the section titled “Cooking and harm
ful
compounds”), the m
eat's heme iron causes oxidation
upon heating and promotes the form
ation of cancer-
causing nitro-samine com
pounds. 260
W
hen using m
eat, favor the following
princip
les:
• Eat a wide variety of anim
al parts (including bones,
bone m
arrow, tongue, connective tissue and offal
such as liver and heart)
• Eat various types of animals
• Favor grass-fed animals, gam
e and indigenous
breeds (Finncattle, H
ighland cattle, bison and sheep)
• Hunt your ow
n meat or arrange for a direct
connection to the origin of the m
eat
• Avoid intensively farm
ed meat, sausages and cold cuts
• Favor long cooking times at low
temperatures,
i.e. slow
cooking and boiling
• Avoid high tem
peratures, i.e. frying, grilling and deep
frying
• When consum
ing meat, add spices that support
digestion and absorption (such as herbs, peppers,
ginger and turm
eric) and foods that support absorp-
tion (such as pineapple, papaya and sauerkraut)
CU
TS OF B
EEF
+
Sold to Fred Block Block (#GJ57M
BGL)
92
FishA
ccording to general dietary guidelines fish is recom-
mended for nutrition and should be consum
ed at least
twice per w
eek. Fish is rich in healthy fatty acids, trace
elements, vitam
ins and amino acids. N
umerous
studies have indicated that fish is an excellent source
of omega-3 fatty acids and vitam
in D. The consum
ption
of fish is associated with a low
er risk of cardiovascular
diseases.
Environmental toxins such as dioxins and PC
Bs are
concentrated in fish fat. The fattier the fish, the higher
the level of toxins. The highest levels of mercury can
generally be found in sharks, swordfish and bigeye
tuna. Toxins become concentrated in long-lived and
large predatory fish.
In 2013 more than 90
countries signed the
Minam
ata convention in
Japan. The convention
prohibits the import and
export of mercury and
mercury-containing products. 261 The convention also
limits m
ercury emissions for exam
ple by prohibiting the
introduction of new m
ercury mining sites. It has been
estimated that as a result of the M
inamata convention,
the mercury levels of fish w
ill fall within decades. Toxic,
carcinogenic substances are largely released into the
environment by hum
an industrial activity (such as coal-
fired electricity generation, smelting and the incinera-
tion of waste).
According to several studies, the benefits of eating fish
exceed any disadvantages involved. 262 Liberal fish con
sumption m
ay reduce the risk of developing coronary
artery disease, 263 lung cancern264 and type 2 diabetes. 265 266
Fish oil (and fresh fish) raises the adiponectin level
in the body, 267 Adiponectin deficiency can be a
predisposing factor for obesity, metabolic syndrom
e
and other metabolic disorders. A
diponectin has anti-
inflamm
atory and oxidative stress preventive effects. 268
Sold to Fred Block Block (#GJ57M
BGL)
93
W
hen using fish, favor the follow
ing p
rinciples:
• Eat the whole fish and use the nutritionally valuable
guts for fish stock
• Eat various types of fish that contain few chem
icals
and heavy m
etals (see the image on the follow
ing
page)
• Favor wild fish and supplem
ent your diet with
organically farm
ed fish
• Catch your ow
n fish or arrange for a direct connection
to the origin of the fish
• Avoid intensively farm
ed fish, processed fish products
and deep fried fish products
• Favor long cooking times at low
temperatures,
i.e. slow
cooking and boiling
• Avoid high tem
peratures, i.e. frying, grilling and
deep frying
• When consum
ing fish, add spices that support
digestion and absorption (such as herbs, peppers,
ginger, dill, turm
eric and coriander)
• You can alleviate any impact of the heavy m
etals
contained by the fish by adding seaw
eed, chlorella
and coriander
The health imp
act of wild
fish comp
ared
to farmed
fish: 269 270 271
• Wild fish has a higher level of om
ega-3 and more
trace elem
ents and vitamins
• Wild fish contains few
er poor quality fat compounds
• Antibiotics, horm
ones, PCB
, neurotoxins, pesticides
and other toxins have been found in farm
ed fish
• Wild fish m
ay contain more m
ercury than farmed fish
+
Sold to Fred Block Block (#GJ57M
BGL)
94
Safe to eat 2–3tim
es per w
eek
Flounder Shrim
pSalm
on (farmed)
Com
mon sole
Octopus/squid
Crayfish and crab
SardineW
hitefishH
erringM
ussels, clams
and oystersTroutC
od
LOW
Safe to eat app
rox. once p
er week
PerchLobster A
tlantic salmon
Burbot
Seabass*M
onkfish*A
tlantic halibut Tuna (canned, Skipjack)
MO
DE
RA
TE
Safe to eat 1–2tim
es per m
onth
PikeYellow
fin tuna Tuna (canned, A
lbacore)
HIG
H
Avoid
Bigeye tuna
Swordfish
VE
RY
HIG
H
See the WW
F or the Seafoodwatch lists of seafood species to avoid (overfishing etc). Favor M
SC certified fish.
Mercury levels in seafood
Sold to Fred Block Block (#GJ57M
BGL)
95
Crustaceans and
molluscs
Two w
arring New
Guinea tribes agree on a cease-fire to
do trade: the coastal tribe offers crustaceans and in re-
turn receives root vegetables from the tribe inhabiting
the highlands. The nutritional value of crustaceans and
molluscs has been w
ell known historically. For instance
oysters have been used as an aphrodisiac.
Crustaceans usually include crabs and lobster. M
olluscs
include clams, oysters, snails and cuttlefish. Shellfish
has been used as a food item for over hundreds of
thousands of years especially in the coastal regions (for
example in the M
editerranean).
Oysters are by far the m
ost nutrient rich of the
molluscs. O
ysters contain the most zinc in proportion
to their weight. For instance, four m
edium-sized
oysters provide 33 mg of zinc, an enorm
ous amount
of selenium, vitam
ins of the B com
plex, vitamin E,
copper, as well as proteins and om
ega-3 fatty acids. 272
Other nutritious species include clam
s, mussels,
lobsters and snails. It should be noted that the ever-
popular shrimp are nutritionally lacking com
pared to
other crustaceans and may contain harm
ful bacteria
and traces of medicines due to intensive farm
ing. As
much as 74 %
of shrimp farm
ers in Thailand have used
antibiotics to treat various shrimp diseases. 273
Favor:
• Oysters
• Clam
s
• Mussels
• Scallops
• Lobster, crab and crayfish
• Snails
• Cuttlefish
A
void:
•
Shrimp
+–
Sold to Fred Block Block (#GJ57M
BGL)
96
EG
GS
As is the case for m
ost containers of a new life, an egg
is close to perfect food. Eggs are rich in protein, vitamins,
minerals and other beneficial nutrients (including
phospholipids, lutein, zeaxanthin and choline). Eggs
are a good source of xanthophylls which are essential
to the eye health of the elderly in particular. They
increase the carotenoid levels of the blood serum as
well as eye tissue. 274 Lutein and zeaxanthin reduce the
risk for macular degeneration and cataracts. M
acular
degeneration most com
monly occurs in people over
the age of fifty. In the United States, it is the m
ost
comm
on cause of vision loss within this age group.
Many people continue to avoid the regular consum
p-
tion of eggs even though the link to increased risk of
coronary artery disease has been refuted in all recent
studies and meta-analyses. 275 276 277 Studies conducted
have found no evidence of a link between egg con-
sumption and high cholesterol levels. 278 Indeed, studies
have found that individuals who consum
e more eggs
have a 25 % low
er risk of having a hemorrhagic stroke.
Eggs do not increase the risk of cardiovascular diseases
or stroke, even when consum
ed daily.
How
ever, eggs are not suitable for everyone. Some
people are allergic to eggs, some suffer from
hereditary
dysfunctions in fatty-acid metabolism
, and some people
(around 20 % of the population in the U
S) have the
ApoE4-allele (genetic variant) w
hich might cause
dysregulation of cholesterol metabolism
. These
individuals as well as diabetics, for exam
ple, should
limit their egg consum
ption.
There is a more realistic risk of developing a hyper-
sensitivity to egg proteins as a result of regular egg
consumption. D
ue to this, everyone who consum
es
eggs should take regular breaks in egg consumption.
In Australia and the European U
nion, eggs are graded
by the hen farming m
ethod (free range, battery caged,
etc). The US D
epartment of A
griculture grades eggs by
the interior quality of the egg and the appearance and
condition of the egg shell. Only about 4 %
off the eggs
are produced organically. The color of the shell has
Sold to Fred Block Block (#GJ57M
BGL)
97
nothing to do with egg quality, rather it is indicative of
the breed of the chicken that laid it.
When selecting
egg
s, note the following
criteria:
• Fresh eggs sink in water, old eggs float.
• The egg whites of fresh eggs are firm
er, the whites of
older eggs are m
ore watery.
• The more vivid yellow
the yolk is, the more it contains
fat-soluble vitam
ins and carotenoids.
• Favor organic free range/pastured eggs. Studies have
found these eggs to have significantly higher levels
of good fatty acids and fat-soluble vitam
ins and
carotenoids.
• Avoid indoor eggs (including cage-free eggs) and
caged eggs. C
aged eggs carry an increased risk of
salm
onella.
• Note the packaging date if you buy eggs from
a
superm
arket.
• Vary the type of eggs you eat (for example quail, duck
and goose).
Egg
s should b
e prep
ared in a w
ay that maintains
the flavor and nutrient d
ensity as well as p
ossible:
• The main egg w
hite protein consisting of albumin
contains enzym
e inhibitors when raw
. Because of this,
the egg w
hite should be cooked.
• Avoid eating just the egg w
hite.
• Conalbum
in interefes with iron absorption, avidin
hinders the absorption of the vitam
in B com
plex.
• The yolk should be eaten raw or slightly cooked.
Frying or boiling oxidizes fats, denatures proteins
and destroys one half of the precious xanthophylls
of the egg.
• In terms of flavor and consistency, even a sm
all
difference in the cooking w
ater temperature changes
the egg structure.
• Keep eggs in room tem
perature and use within 7–10
days.
• Refrigerated eggs will keep for approx. 30–45 days.
• Do not eat eggs that are old, have a broken shell or a
w
atery egg white.
Sold to Fred Block Block (#GJ57M
BGL)
98
Cooking
the perfect eg
g
Op
tion 1
Place the eggs in water and raise the w
ater tem-
perature. When the w
ater is boiling, remove from
heat and leave to sit under a lid for 6 minutes.
The internal temperature of the eggs w
ill keep for
several minutes, w
hereas the shells are much less
likely to crack when rem
oved from heat.
Pour the hot water out and replace w
ith cold water.
Add 1 tsp of baking soda. The raised pH
of the
water detaches the egg w
hite from the shell. Leave
the eggs in cold water for 2–5 m
inutes before
eating. An egg that has been com
pletely detached
from the shell can be peeled in an im
pressive way
by blowing the egg out.
RE
CIPE
Op
tion 2
Set the sous-vide temperature to 64.7 C
(148.5 °F)
and cook for a minim
um of 50 m
inutes. Remove
the eggs and place in cold water for tw
o minutes
before peeling. This method produces an egg that
is perfectly al dente. Place the eggs on a plate, cut
in half and add unrefined sea salt, pepper
and herbs.
Sold to Fred Block Block (#GJ57M
BGL)
99
MILK
PRO
DU
CTS
Finns consume the m
ost dairy products in the world
(over 300 kg per person / year). The global average is
about 108 kg per person per year. The consumption
of milk and fat-free m
ilk products in particular may be
linked to deaths caused by heart disease. 279 280 281 On the
other hand, some studies indicate that the consum
p-
tion of full-fat milk products m
ay prevent cardiovascular
diseases and heart attack, 282 abdominal obesity
283 and
type 2 diabetes. 284 According to studies, it seem
s as
though it is the milk fat (trans-palm
itoleic acid) that
prevents obesity and the development of type 2
diabetes. 285 The positive effects of the milk fat m
ay
also be due to CLA
, vitamin K2 and butyric acid.
Excessive milk consum
ption stimulates m
ucus produc-
tion in the respiratory tract via the β-casomorphin-7
peptide of which there is plenty in m
ilk. This peptide
stimulates m
ucus production particularly in asthmatic
individuals and may w
orsen the symptom
s of asthma. 286
For some individuals, giving up m
ilk entirely may help
in the recovery from chronic sinus infection. The inflam
-
matory cycle is particularly com
mon in people w
ho
unknowingly suffer from
milk hypersensitivity. 287
It is comm
only believed
that milk is a good source
of calcium. H
owever, care
should be taken with
liberal milk consum
ption
and particularly when using
calcium supplem
ents as re-
cent studies have indicated
that these are associated
with the developm
ent of
coronary artery disease
and a significant increase in
the risk of a heart attack. 288
High calcium
intake causes
magnesium
deficiency.
Several studies have
indicated that magnesium
is one of the main factors in
the prevention of coronary artery disease. 289 A calcium
-
magnesium
imbalance significantly increases the risk of
a heart attack and may increase the risk of breast cancer
in post-menopausal w
omen. 290 A
study conducted on
Sold to Fred Block Block (#GJ57M
BGL)
100
Finnish males show
ed that large amounts of calcium
in
the drinking water is linked to coronary heart disease
and coronary thrombosis. 291
A com
prehensive Swedish study published in the
esteemed British M
edical Journal found that the liberal
consumption of m
ilk (more than three glasses per day)
may be associated w
ith premature death. The sam
e
demographic study also found that m
ilk consumption
does not prevent the development of osteoporosis.
In fact, it even increases the risk of bone fractures in
wom
en. The liberal consumption of m
ilk also appears
to contribute to low-grade inflam
mation and oxidative
stress of the body. 292
The qualities of milk products vary depending on the
cattle breed of origin. Often the term
s A1 m
ilk and
A2 m
ilk are used. The distinction is made according
to differences in milk proteins betw
een cattle breeds.
A2 m
ilk produced by indigenous cattle breeds cause
significantly fewer health problem
s. Conversely, A
1
milk proteins are associated w
ith heart disease and
intestinal inflamm
ation. 293 294 295 The A1 type is the m
ost
comm
on type found in cow’s m
ilk in Europe (excluding
France), the USA
, Australia and N
ew Zealand.
The diet and living conditions of the cow also have an
enormous im
pact on the quality of the resulting milk
products. For example, the m
ilk of grass-fed cows
contains significantly more om
ega-3 fatty acids. 296 In
addition, the proportion of grass in the cattle diet is
directly proportional to the nutritional value of the
butter produced. 297 Organic m
ilk products also contain
more om
ega-3 fatty acids and CLA
compared to
conventional milk products. 298
Favor:
• Milk products m
ade from the m
ilk of goats, sheep,
Scottish H
ighland, Limousin, Piedm
ontese or other
indigenous breeds of dairy cattle
• Fermented m
ilk products (kefir)
• Grass-fed and organic butter
• Raw m
ilk from sm
all farms
A
void:
• Highly processed m
ilk and fat-free milk products
• Processed milk products such as m
ilk-based drinks
• Yogurts sweetened w
ith sugar and digestive yogurts
+–
Sold to Fred Block Block (#GJ57M
BGL)
101
CE
RE
ALS
The global consumption of grains is m
ainly divided
into three different grains: wheat (Europe, M
iddle-East,
North A
frica and Australia), corn (N
orth and South
Am
erica, Southern Africa) and rice (A
sia). The global
per capita wheat consum
ption is around 67 kg. 70 %
of the cereals eaten are refined. Refining significantly
undermines the nutritional value of cereals (vitam
in B
complex, zinc, m
agnesium, phytoestrogens and
selenium are rem
oved with the husk).
Consum
ing whole grains has been linked to better
health by epidemiological population studies. The
health benefit is likely to be due to the overall better
living habits of people who consum
e wholegrain cereals,
as well as the reduced consum
ption of processed cere-
als, rather than the increased consumption of w
hole-
grain cereals. 299 For instance, wholegrain cereals by them
-
selves do not lower the levels of inflam
matory m
arkers or
improve insulin sensitivity. 300 M
ore so than cereals, there
is significantly more positive evidence for the consum
p-
tion of vegetables preventing many illnesses. 301 302
Gluten, celiac d
isease and g
luten hyp
ersensitivityG
luten is a large-scale protein molecule that consists
of numerous peptides. A
t least fifty of these have been
found to destroy epithelial cells in the intestine, disrupt
the imm
une function and cause leaky gut syndrome. A
pioneer in celiac disease research, Dr A
lessio Fasano,
found in his research that there is increased occurrence
of the zonulin protein in autoimm
une diseases such as
celiac disease. Zonulin modulates the tight junctions
between intestinal cells. The m
ore zonulin there is, the
more perm
eable the gut. 303
When a celiac individual eats gluten, the production of
zonulin proteins increases imm
ediately. 304 This in turn
stimulates the secretion of inflam
matory cytokines,
causing the loosening of the tight junctions and, if
prolonged, their destruction. This process can be almost
Sold to Fred Block Block (#GJ57M
BGL)
102
entirely prevented by avoiding gluten in the diet. Over
time, the am
ount of zonulin is reduced and the epithelial
cells and tight junctions of the intestine are repaired.
Gluten hypersensitivity is m
any times m
ore comm
on in
humans than celiac disease. Testing for celiac disease
with laboratory tests does not rule out gluten hypersen-
sitivity, as the latter cannot currently be reliably tested
in a laboratory. Increased gut permeability has not
been found in individuals with gluten hypersensitivity.
As a result it is not considered an autoim
mune disease.
Gluten hypersensitivity and celiac disease are entirely
distinct. 305
Many individuals w
ho have experimented w
ith a grain-
free diet report experiencing health benefits. Typically
a grain-free diet is attempted w
hen an individual suffers
from irritated bow
el syndrome, celiac disease or other
autoimm
une diseases or certain psychiatric illnesses. 306
Many people consider gluten to be the culprit of intes-
tinal symptom
s. In addition to gluten, the cause may be
the FOD
MA
P carbohydrates found in cereals (see the
section titled “FOD
MA
P carbohydrates”) 307 and other
cereal proteins.
We recom
mend relying on vegetables and root crops
for dietary carbohydrate needs and adding gluten-
free products such as oat, quinoa and buckwheat as
needed. Favor indigenous varieties of cereals over
highly processed ones. For example, indigenous w
heat
varieties alleviate the inflamm
ation and symptom
s of
IBS patients, 308 w
hereas modern w
heat varieties worsen
them. 309
Favor:
• Am
aranth
• Millet
• Oat
• Canihua
• Quinoa
• Buckw
heat
• Teff
A
void:
• Wheat and other w
heat varieties that contain gluten
(spelt, einkorn and em
mer w
heat)
• Barley
• Rye
• Maize
+–
Sold to Fred Block Block (#GJ57M
BGL)
103
Rice
Rice is a type of grass. According to som
e estimates,
more than 90 %
of the world’s rice is grow
n in Asia. Rice
is one of the main sources of nutrition for up to one half
of the world’s population.
Rice is typically categorized into long, medium
and
short grain varieties. Long grain varieties are rich in
amylose. Short-chain and som
e long grain rice varieties
are rich in amylopectin, for exam
ple in Thai sticky rice.
Due to the function of digestive enzym
es amylopectin
may raise the blood sugar level m
ore rapidly than
amylose. 310
Wholegrain rice is m
ore nutrient rich than white
rice. How
ever, it contains antinutrients that interfere
with nutrient absorption (see the section titled
“Antinutrients”), as w
ell as other toxins such as soil-
based arsenic. The nutritional value of wholegrain rice
decreases significantly upon cooking. White rice
varieties (such as basmati and jasm
ine rice) are less
nutrient rich than wholegrain rice. H
owever, they do
not contain antinutrients.
White rice m
ainly consists of starch, some protein
and certain trace elements. To rem
ove impurities, rice
should always be properly soaked. The biohacker uses
rice mainly to provide glucose for the nervous system
and supplement the glycogen reserves in the m
uscles
and liver, as a part of an otherwise nutrient-rich diet.
Favor:
• Basm
ati rice
• Jasmine rice
• Other types of long grain rice
A
void:
• Instant rice
• Porridge rice
• Short grain rice
• Wholegrain rice
• Brow
n rice
+–
Sold to Fred Block Block (#GJ57M
BGL)
104
Maize
Maize (corn) is a m
ember of the grass fam
ily. It is an old
staple crop with an estim
ated cultivation history dating
as far back as 9000 years ago in Mexico. 311 Today m
aize
is the most w
idely grown grain in the w
orld. As m
uch
as 40 % of all m
aize is produced in the United States, of
which, up to 86 %
is genetically manipulated. In 2011,
32 % of the m
aize produced in the world w
as genetically
manipulated. Intensive m
aize farming is also harm
ful
to the environment, for instance, via groundw
ater
pollution. 312
In the United States, 40 %
of the maize grow
n is used
for the production of ethanol. Maize is also used as
animal feed, m
ost comm
only for pigs but also for
cattle. Maize feed fattens up the livestock rapidly,
facilitating high livestock production volumes.
For human consum
ption, maize is traditionally used
in tortillas, porridge, polenta, popcorn and corn
flakes. Mexican cuisine in particular holds m
aize
in a key role. There are six varieties of maize: dent
corn, sweet corn, flour corn, flint corn, popcorn and
pod corn. Most of the m
aize grown in the U
nited States
is yellow dent corn.
On a global scale, m
aize is one of the most significant
sources of starch. 313 Used in its original form
, organic
non-GM
O corn can be a fairly econom
ical and solid
option to supplement one’s diet particularly during
seasons that are optimal for grilling. H
owever, m
aize is
not suitable for consumption for som
e celiacs due to its
zein content (a gluten-like prolamine com
pound) which
may cause an im
mune reaction in the intestine sim
ilar
to celiac disease. 314
Maize is frequently turned into high fructose corn
syrup which is used as a sw
eetener in many foods
and drinks. The abundant use of high fructose corn
syrup has been linked to the occurrence of diabetes
in various countries. 315 It is also a predisposing factor
for excess weight, m
etabolic syndrome and the onset
of fatty liver disease. 316 Some scientists suggest that
the contribution of high fructose corn syrup to excess
weight is prim
arily due to an unnoticed increase in
energy intake. 317
Sold to Fred Block Block (#GJ57M
BGL)
105
The consumption of foods containing high fructose
corn syrup has also been found to have a dose-
response relationship to the onset of coronary
artery disease – the higher the consumption of
high fructose corn syrup, the higher the risk of the
disease. 318 Maize is also used to m
ake corn oil, of
which the fatty acid com
position is unfavorable
for humans.
Corn oil contains high levels of polyunsaturated
omega-6 fatty acids (54 %
) that oxidize readily
and, when consum
ed excessively, predispose
the body to silent inflamm
ation. 319 In the United
States, corn oil in particular is likely to be one
of the main reasons for the extrem
ely poor ratio
of omega-6 and om
ega-3 fatty acids in the
population (up to 20:1).
Sold to Fred Block Block (#GJ57M
BGL)
106
RO
OT V
EG
ETA
BLE
S AN
D TU
BE
RS
Root vegetables refer to the underground parts of a
plant that are used for food. Root vegetables include
the roots, shoots and bulbs of many seed plants. Root
vegetables are very comm
on all over the world. There
are more than 50 types of storage roots, w
hich are
categorised in bulbs, rhizomes and tubers. The m
ost
comm
on ones are carrots, beetroots, cassava, rutabaga,
turnips, yams, sw
eet potatoes, radishes and celeriac.
Root vegetables are nutritionally valuable due to the
fiber, vitamin C
, vitamin B
complex and calcium
con-
tained by them. C
arrots contain particularly high levels
of beta-carotene and other carotenoids. 320
PotatoThe potato w
as slowly adopted into Europe in as late
as the 19th century, but it soon after became an im
por-
tant staple food. Potatoes at that time w
ere used to
prevent scurvy because of their vitamin C
content.
Contrary to com
mon belief, the potato is not a root
vegetable but a nightshade. Other sim
ilar nightshades
are eggplants, tomatoes and peppers.
Potatoes are fairly rich in nutrients such as potassium,
vitamin B
complex and vitam
in C. 321 The potato is also
one of the prime foods to prom
ote the feeling of
satiety. 322
Potatoes contain some glycoalkaloids (alpha-solanine
and beta-chaconine) which are toxic to hum
ans.
How
ever, their levels in cultivated potato varieties are
low. The solanine level of a potato m
ay be significantly
increased if it is exposed to sunlight during the growing
season. Toxic potatoes can be identified based on their
green color or sprouting. Early crop potatoes contain
the most solanine. G
lycoalkaloids may cause sym
ptoms
such as headache, diarrhea, restlessness and nausea. 323
Sold to Fred Block Block (#GJ57M
BGL)
107
Glycoalkaloids are present particularly in potato skins.
As a result, peeling the potatoes significantly reduces
their solanine content. Unpeeled potatoes fried in oil
are especially problematic as glycoalkaloids are oil-
soluble. Potatoes cooked in high temperatures also
produce toxic compounds such as acrylam
ide and
acrolein.
Sweet p
otatoThe consum
ption of sweet potatoes increased in
popularity after Christopher C
olumbus introduced
it in Europe. Sweet potatoes are often used as a
replacement for w
hite potatoes. They are more
nutrient rich than the conventional potato. For
instance, sweet potatoes contain m
ore beta-carotene,
anthocyanins, vitamin C
and fiber. It also raises the
blood sugar level more slow
ly compared to potatoes. 324
On the other hand, potatoes contain m
ore resistant
starch that may be helpful in the m
aintenance of the
bacterial strain of the intestine (see the section titled
“Prebiotics”). 325
We recom
mend that potatoes and sw
eet potatoes be
consumed especially after strenuous exercise to
supplement the depleted glycogen reserves in the
muscles.
Favor:
• A w
ide variety of seasonal root vegetables
• Organic potatoes
• Boiling and steam
ing potatoes
• Seasonally grown local potatoes
• Large-sized tubers (less glycoalkaloids)
• So-called almond potatoes (m
ostly grown in Finland,
Sw
eden and Norw
ay), which have high levels of
resistant starch
A
void:
• Potatoes deep fried in oil
• Potato chips
• Other heavily processed potato products
• Eating potato peels
• Green and dam
aged potatoes
• Very small-sized tubers (m
ore glycoalkaloids)
+–
Sold to Fred Block Block (#GJ57M
BGL)
108
VE
GE
TAB
LES, FR
UITS A
ND
B
ER
RIE
S
It is generally recomm
ended to eat 5–9 portions
(around 400 grams) of fruits, vegetables and berries
daily. Only about 10 %
of people meet these
recomm
endations. A study conducted in Finland
showed that 75 %
of Finnish males ate only tw
o
servings of fruits, vegetables and berries per day. 326
Com
prehensive meta-analyses have found that the
liberal consumption of vegetables, berries and fruits is
linked to a lowered risk of death, particularly in relation
to cardiovascular diseases. 327
There is significant variability in the absorption of
many vegetables, fruits and berries depending on the
preparation method. The sam
e compound m
ay also
be absorbed differently from different ingredients. For
example, the beta-carotene and lycopene contained by
papaya are more readily absorbed com
pared to those in
carrots. 328
RECO
MM
END
ED D
AILY IN
TAKE
400g
1 PA
RT
2 PA
RTS
3 PA
RTS
berriesfruits
vegetables
++
Sold to Fred Block Block (#GJ57M
BGL)
109
It is recomm
ended to acquire nutrients from vegetables
and berries by consuming them
with fat to im
prove
absorption. 329 Fruits and root vegetables may be used
to supplement the diet particularly after exercise or in
the evening to encourage sleep.
FruitsSom
e fruits can be used strategically for specific
health benefits. For instance, kiwi fruit has been
found to promote the grow
th of probiotic bacteria in
the intestine330 and help in the treatm
ent of irritable
bowel syndrom
e. 331 The polyphenols in kiwi fruit act
as antioxidants and protect the body from oxidative
stress. 332 Kiwi fruit also contain five tim
es more vitam
in
C than oranges, for exam
ple.
90% of pesticide residues com
e from intensively
farmed, im
ported fruit. 333 When buying fruit it is
worthw
hile to invest in organic produce to minim
ize the
amount of harm
ful toxins.
Rip
ening avocad
os
In nature, avocados only ripen once they
fall off the tree. You can ripen avocados
by keeping them in room
temperature.
To speed up the process, place the
avocados together with bananas in a
small bag (for exam
ple a biowaste bag)
overnight. Bananas are treated w
ith
ethylene, a plant hormone gas used
to speed up the ripening process. This
compound also accelerates the ripening
of avocados. TIP+
Sold to Fred Block Block (#GJ57M
BGL)
110
Favor:
• Locally grown, seasonal fruit (for exam
ple apples)
• Organic fruit
• Fatty fruits (such as avocado, olive)
• Low-sugar fruits (lem
on, lime, grapefruit, kiw
i fruit)
• Nutritious fruits that contain slightly m
ore
sugar (papaya, nectarines, peaches, w
atermelon,
pom
egranates, apples)
Use sp
aringly:
• Varieties cultivated for extreme sw
eetness
– M
ango, fig, banana and dried fruits such as dates,
raisins and apricots
– O
ptimal tim
e of consumption is after exercise
or in the evening
• Varieties cultivated for sweetness
– M
andarin, orange, pear, plum and pineapple
A
void:
• Com
mercial fruit juices and concentrated juice
• Artificially added fructose
Lemon w
ater
Get hydrated first thing in the m
orning
by squeezing the juice of half a lemon
into approximately half a quart of w
ater
mixed w
ith half a teaspoon of high
quality salt. Lemon juice supports the
digestive system and acts as a diuretic,
increasing the need to urinate and
hence removing w
aste products that
have accumulated in the body overnight.
Salt helps the adrenal glands produce
cortisol needed for waking up – essential
in the early hours of the morning.
TIP
+–
Sold to Fred Block Block (#GJ57M
BGL)
111
Fruit
Ap
ple (p
eeled)
Ap
ricot (de-stoned
)
Avocad
o
(peeled
, de-stoned
)
Banana (p
eeled)
Date (d
ried)
Fig (fresh)
Grap
e (de-stoned
)
Grap
efruit
(peeled
)
Kiw
ifruit (peeled
)
Lemon (d
e-stoned)
Sugar
8.2 %
10.6 %
0.7 %
13.5 %
38.2 %
16 %
15.5 %
6.5 %
6.8 %
2.2 %
Main nutrients
Quercetin, epicatechin, fibers (2.4 %
).
Carotenoids, potassium
, manganese, vitam
in A.
Monounsaturated fatty acids, linoleic acid and alpha-linolenic acid. Sterols,
potassium, m
agnesium, phosphorus, carotenoids, vitam
in K, vitamin B
complex.
Potassium, tryptophan, m
anganese, magnesium
, vitamin B
6.
Potassium (687 m
g / 100 g), magnesium
, phosphorus, vitamin B
complex,
manganese.
Potassium, m
agnesium, phosphorus, carotenoids, vitam
in K.
Vitamin K, vitam
ins B1, B
2 and B6.
Vitamin C
, carotenoids, pantothenic acid, pectin, lycopene.
Grapefruit seed oil has antim
icrobial properties.
Vitamin C
(100 mg / 100 g), pantothenic acid, vitam
in E.
Vitamin C
(51 mg / 100 g), vitam
in B6, iron.
The sugar and
nutrient content of fruitsSource: Fineli (N
ational Food Com
position Database in Finland), 2015.
Sold to Fred Block Block (#GJ57M
BGL)
112
Fruit
Lime (p
eeled)
Mand
arine (peeled
)
Mang
o (peeled
)
Olive (d
e-stoned)
Orang
e (peeled
)
Papaya
Peach (peeled
,
de-stoned
)
Pear (peeled
)
Pineapp
le (peeled
)
Plum (d
e-stoned)
Pomeg
ranate
Waterm
elon (peeled
)
Sugar
1.7 %
8.2 %
13.7 %
0 %
8.9 %
10.7 %
7.8 %
8.0 %
11.2 %
8.2 %
13.7 %
7.1 %
Main nutrients
Vitamin C
, some vitam
in B com
plex, calcium and iron.
Vitamin C
, carotenoids, potassium.
Folate, vitamin C
, carotenoids, potassium.
Monounsaturated fatty acids, vitam
in E, sodium.
Vitamin C
, potassium, calcium
.
Vitamin C
, carotenoids, potassium.
Potassium, niacin, phenols.
Vitamin C
, potassium, fibers.
Potassium, vitam
in B com
plex, vitamin C
, carotenoids; bromelain enzym
e.
Potassium, carotenoids, vitam
in K.
Linoleic acid, ellagitannin, anthocyanin, vitamin B
complex.
Carotenoids, vitam
in C, citrulline.
Sold to Fred Block Block (#GJ57M
BGL)
113
Berries
If there is one dietary recomm
endation that all
experts agree on, it is the health benefits of berries.
Regardless of the diet type, nearly all dietary guide-
lines recomm
end the daily consumption of 150–200 g
(5–7 oz) of berries.
In general, berries are rich in vitamins, flavonoids,
polyphenols, anthocyanins and insoluble fiber. They
contain less sugar compared to fruit. Polyphenols
give berries their distinctive color and act as part of
various defense mechanism
s. Whenever possible it is
very beneficial to eat nutrient rich wild berries as they
have much higher levels of polyphenols com
pared
to cultivated berries. Cultivated berries often contain
pesticide residues, such as non-organic strawberries
which contain high levels of pesticides. 334
The regular consumption of berries protects the
cardiovascular system from
oxidative stress, lowers
blood pressure and reduces the level of inflamm
atory
agents in the blood. Berry consum
ption also lowers
the risk of type 2 diabetes. Additionally, berries have
properties that promote the health of the eyes and
brain. 335
In tests conducted on animals, bilberries w
ere found
to have a positive effect on cognitive functions. 336 The
consumption of bilberries has been found to low
er the
risk of cardiovascular disease in individuals suffering
from m
etabolic syndrome. 337 In tests conducted on rats,
wild blueberries w
ere found to promote the bacterial
balance and general well-being of the intestine. 338 The
anthocyanins contained by bilberries and black currants
have been found to improve night vision, ease eye
fatigue and help in the treatment of glaucom
a. 339 340
Sold to Fred Block Block (#GJ57M
BGL)
114
Be careful w
hen buying imported frozen berries. There
have been many cases of outbreaks in w
hich frozen
berries have been contaminated w
ith the norovirus, the
hepatitis A virus or cam
pylobacter. Boil your frozen
berries for at least two m
inutes, or cook at 90 °C / 194 °F
for five minutes to avoid food poisoning. 341 Exotic berries
such as goji, inca and mulberry have been trendy in the
past few years. The nutritional values of these berries
are indeed good, however they m
ay contain pesticide
residues and sulfur dioxide used as a preservative.
Favor:
• Wild berries: bilberries, lingonberries, cranberries,
blackcurrant, sea buckthorn, cloudberries, choke-
berries (aronia), arctic raspberries, crow
berries,
row
anberries, wild raspberries and w
ild strawberries
• Locally grown cultivated berries
• Berry pow
ders
• Imported organic berries (such as inca berries,
m
ulberries and goji berries)
A
void:
• Imported frozen berries
Berry p
owd
er mix
Berries contain im
portant building
blocks for eyes. Mix berry pow
ders of
different color in equal measure, for
example:
• Blue: bilberry and black currant
• Red: cranberry and lingonberry
• Yellow: sea buckthorn and cloudberry
Mix one tablespoon of the pow
der
in your breakfast each morning. For
comparison, 1 teaspoon of high quality
berry powder is equivalent to a half a
cup of berries. TIP
+–
Sold to Fred Block Block (#GJ57M
BGL)
115
Vegetab
lesVegetables m
ainly refer to cultivated plants of which
the juicy parts growing above ground are used for
food. The top five vegetables in the US, based on
how m
uch households spend on them, have rem
ained
almost the sam
e for the past 20 years: tomatoes,
potatoes, mushroom
s, lettuce and carrots. The most
popular vegetable is tomato, w
hich is not a bad choice.
Lycopene in tomatoes has been found to protect from
cancer, stroke and cardiovascular disease. 342
Num
erous studies done on vegetables advocate
their consumption. Eating plenty of green vegetables
is particularly beneficial. Vegetables are rich in
phytonutrients such as flavonoids and polyphenols as
NU
TRIENT D
ENSITY C
HA
RT
Source: CD
C
20
40
60
80
100
Sold to Fred Block Block (#GJ57M
BGL)
116
well as trace elem
ents and vitamins. The darker the
color, the more likely the vegetable is to contain
plenty of these protective nutrients that reduce
silent inflamm
ation343 and prevent various kinds of
cancer. 344
Intensely colored vegetables also have properties that
protect from type 2 diabetes, w
hich was not evident
for example in relation to fruits. 345 346 347 The liberal
consumption of vegetables also low
ers the risk of
coronary artery disease and stroke. 348 349
Eating cruciferous vegetables such as broccoli lowers
the risk of stomach
350 and lung351 cancer. Broccoli
contains sulforaphane which has been found in several
studies to have breast cancer preventive effects. 352 353
For men, four servings of broccoli per w
eek may
prevent prostate cancer. 354 Eating broccoli regularly
helps the liver remove various toxins from
the system,
supports endocrine function and maintains the function
of antioxidants in the system. 355
Flavonoid
subcateg
ory
Anthocyanins
Flavanols
Flavones
Flavonols (such
as quercetin)
Flavones
Isoflavones
Typical food sources
Red, blue and purple berries; red and
purple grapes; red wine
Catechins: Tea (particularly green and w
hite
tea), chocolate, grapes, berries, apples
Theaflavins and thearubigins: Tea
(particularly black and oolong tea)
Proanthocyanidins: chocolate, apples,
berries, red grapes, red wine
Citrus fruit (such as oranges, grapefruit
and lemons)
Capers, yellow
onions, lovage, dill, leeks,
spring onions, cabbage, broccoli, apples,
berries, tea
Parsley, thyme, celery, hot peppers
Soybeans, legumes
Source: Linus Pauling Institute
Sold to Fred Block Block (#GJ57M
BGL)
117
Wild
greens
Harvesting w
ild greens is called foraging. In Greece,
for example, foraging is a long-standing tradition.
Wild plants are not just w
orthless weeds. The interest in
foraging these has seen a rapid rise in popularity in the
recent years. The most w
ell-known and easy-to-use
wild greens include nettle, dandelion, firew
eed, yarrow,
ground elder and plantago.
Wild greens are hardier than traditional cultivated
plants, contain more antioxidants, vitam
ins and trace
elements and do not contain pesticides. W
ild greens
are also significantly stronger in flavor than traditional
vegetables. How
ever, select the harvesting site carefully
to minim
ize pollution caused by traffic, etc.
Many w
ild greens are superior when com
pared to
supermarket offerings. For exam
ple, nettle contains
five times m
ore iron than spinach. In studies, nettle has
been found to lower blood sugar in type 2 diabetics, 356
ease joint pain357 and reduce prostatic hyperplasia. 358
Similarly, dandelion is generally m
uch more nutrient-
rich than cultivated lettuce.
Favor:
• Wild greens
• The darkest green vegetables such as kale and chard
• Sprouts and new crops
• Cabbages
• Onions (particularly colorful ones)
A
void:
• Iceberg lettuce and other similar varieties containing
few
nutrients
• Pale, wilted or translucent vegetables
• Mass produced vegetables
• Uncooked nightshades that are rich in antinutrients
and particularly eggplant if you are sensitive to
nicotine
+–
Sold to Fred Block Block (#GJ57M
BGL)
118
FATS AN
D O
ILS
All butter sold in the U
nited States must be com
posed
of at least 80 % m
ilk fat. In Europe, the EU legislation
dictates that butter cannot have any additional ingre-
dients, such as vegetable oils added to it. Butter m
ade
from a ferm
ented cream is know
n as cultured butter,
whereas butter m
ade from pasteurized fresh cream
is
called sweet cream
butter. Throughout Europe cultured
butter is preferred, while sw
eet cream butter is m
ore
prevalent in the United States. France ranks first in per
capita butter consumption w
ith over 8 kg (17 pounds)
per person per year. Margarine has becom
e a major
part of the Western diet and had overtaken butter in
popularity in the mid-20th century.
According to folklore, saturated fats (i.e. hard fats)
cause cardiovascular diseases. A com
prehensive meta-
analysis from 2014 does not support this hypothesis. 359 360
Systematic research preceding this study also show
ed
that there is no causality between saturated fat and
cardiovascular disease. 361 362
The health benefits of fats and oils are often seen only
from the view
point of fatty acids and fat metabolism
.
How
ever, many oils also contain other health
beneficial compounds such as polyphenols.
Adding fats or for exam
ple avocado into
food may also im
prove the absorption of
fat-soluble compounds. 363
The processing method used in the oil has
a crucial impact on its health benefits. If the
oil is refined instead of cold-pressed, i.e.
if it is heated to up to 260 °C (500 °F), the
quality and properties are significantly comprom
ised.
The refinement and im
purity removing process also
removes plant sterols, chlorophyll, flavoring agents,
polyphenols acting as antioxidants, lignans, lecithin,
squalene and other fat-soluble active substances.
Coconut oil
Cold-pressed virgin coconut oil should not be confused
with coconut shortening often used for deep frying.
Virgin coconut oil does not contain traces of the solvents
used when processing shortening, nor has the oil been
refined, bleached or hydrogenated. Virgin coconut oil
contains phenolic compounds that act as antioxidants
(such as ferulic acid, p-Coum
aric acid and tocopherols)
which are not present in coconut shortening.
Sold to Fred Block Block (#GJ57M
BGL)
119
Virgin coconut oil has been shown to have a better
antioxidant effect than highly processed coconut oil. 364
The polyphenols of virgin coconut oil have been found
to calm inflam
mation. 365 In anim
al tests, virgin coconut
oil was found to im
prove fat metabolism
and lower the
risk of coronary artery disease. 366
Butter and
ghee
Butter contains m
any nutrients such
as CLA
and vitamins A
, D and K.
High quality butter also contains
trace amounts of om
ega-3 fatty
acids. The quality and healthiness of
the butter depends on the proportion
of grass in the producing cow’s diet, 367 the cow
’s
general health and the time it spent outdoors, as
well as the level of nutrients in the soil.
Saturated fat and in particular the fatty acids present
in butter are needed for the normal function of cell
mem
branes and the heart, to carry calcium into the
bones and for hormone production. The saturated
fat in butter also significantly increases the feeling of
satiety.
Making
a high q
uality spread
Use a blender to m
ix in equal amounts:
• As high quality butter as possible
(grass-fed, unsalted butter)
• Cold-pressed organic virgin olive oil
• Spring water
For example, com
bine 100 g (1 stick) of
butter, 1 dl (half a cup) of olive oil and
1 dl (half a cup) of water. B
lend the
ingredients and season with high quality
salt and for example garlic or basil.
RE
CIPE
++
Sold to Fred Block Block (#GJ57M
BGL)
120
The traditional Indian method of m
aking clarified
butter (ghee) removes the m
ilk proteins from the butter,
making the resulting product lactose-free. B
ecause
ghee contains no milk protein, it can w
ithstand high
temperatures. This m
akes it a very good oil for cooking.
Ghee does not contain harm
ful trans fats that can
cause heart disease and other serious health problems.
Ghee and butter contain butyric acid w
hich can reduce
intestinal inflamm
ation. 368 369
Olive oil
Good olive oil is m
ade by picking
and selecting the olives by hand.
The olives are pressed within 18
hours of picking. The pressing
occurs at a temperature below
27 °C
(80 °F), retaining all of the natural
antioxidants of the olives.
High quality olive oil has been show
n to have similar
inflamm
ation-reducing effects as anti-inflamm
atory
drugs. 370 These and numerous other benefits occur
thanks to the many phenol com
pounds of virgin olive
oil. 371 Oleocanthal in particular has been found to
have therapeutic properties. 372 It has been assessed
that virgin olive oil is the primary com
ponent of the
Mediterranean diet in treating chronic illnesses, due to
its anti-inflamm
atory properties. 373
The regular use of virgin olive oil is associated with
a lower risk of stroke, cerebrovascular disorder and
various types of cancer. 374 Virgin olive oil has also been
shown to low
er the risk of cardiovascular disease. 375 376
In addition, brain health and performance m
ay be
improved w
ith the regular use of virgin olive oil. 377 378
Fish oil and fish liver oil
Fish oil and fish liver oil are recomm
ended for
individuals who do not eat enough fatty fish. G
eneral
guidelines recomm
end eating fatty fish twice per w
eek.
Fish and other seafood contain long-chain omega-3
fatty acids (EPA and D
HA
). Om
ega-3 fats can be
found in many vegetable oils, but they m
ostly contain
short-chain alpha-linolenic acid (ALA
) which is poorly
absorbed particularly in men.
Fish oil and fish liver oil are sold in various formats.
When using om
ega-3 capsules it is important to m
ake
Sold to Fred Block Block (#GJ57M
BGL)
121
sure the capsules do not react with light or air. The
oxidation of omega-3 fats causes harm
ful reactions
in the system. 379
The intake of omega-3 fatty acids im
proves mood,
increases attentiveness and generally improves
cognitive functions. 380 According to a study report,
omega-3 fatty acids (particularly EPA
) are highly
beneficial especially in the treatment of depression. 381
The intake of omega-3 fatty acids (particularly E-EPA
)
reduces the silent inflamm
atory condition of the system
which is often a contributing factor to m
any chronic
illnesses. 382
Docosahexaenoic acid (D
HA
) has been shown to
improve m
emory and reaction tim
e in healthy young
adults. 383 In addition, DH
A slow
s down the aging of
the brain, may prevent dem
entia384 and im
proves
learning. 385
Om
ega-3 preparations are often used as dietary
supplements to prom
ote cardiovascular health.
How
ever, in light of recent meta-analyses, the evidence
is non-conclusive. 386 387 Om
ega-3 fatty acids do lower
blood pressure388 and D
HA
also improves blood lipid
levels. 389 In wom
en, the use of omega-3 appears to
reduce the risk of stroke. 390
Vegetab
le oilsH
igh quality vegetable oil blends may help in achieving
a good balance of fatty acids in the system. H
owever,
some vegetable oils are not beneficial due to their high
level of omega-6 fatty acids. Processed vegetable oils
are also highly oxidizing and may increase inflam
mation
in the system for that reason alone. 391
The balance ratio of omega-6 and om
ega-3 in
indigenous people was approxim
ately 2:1 which is
considered ideal. The imbalance of fatty acids m
ay
cause silent inflamm
ation in the system. 392 In Europe
the ratio is on average 8:1 and in the US up to 20:1.
Sold to Fred Block Block (#GJ57M
BGL)
122
Favor:
• Organic fats and oils rich in om
ega-3 fatty acids
• Ghee and butter
• Fish liver oil and krill oil
• Cold-pressed virgin olive and coconut oils
• Cold-pressed avocado, m
acadamia and hem
p oils
• Oils stored in dark glass bottles, protected from
light and heat
• High quality cold-pressed vegetable oil blends
• Dietary supplem
ents of cold-pressed linseed oil
and w
heat germ oil
A
void:
• Hydrogenated vegetable fats
• Vegetable oils rich in omega-6 fatty acids
• Oils stored in plastic bottles
• Oxidized oils, oils exposed to light and heat
Oil
Canola
Hem
p
Linseed
Macad
amia
Maize
Peanut
Rap
eseed
Soy
Sunflower
Walnut
Om
ega-6
level
20 %
55 %
14 %
3 %
54 %
32 %
20 %
51 %
65 %
52 %
Om
ega-3
level
9 %
22 % (A
LA)
57 % (A
LA)
0 %
0 %
0 %
9 %
7 %
0 %
10 % (A
LA)
Vegetab
le oil levels (omeg
a-6 and om
ega-3)
+–
Sold to Fred Block Block (#GJ57M
BGL)
123
MatchaG
yver Ice Cream
This heavenly ice cream com
bines the nutrient-rich properties of egg yolks, the benefits of fats, green
tea polyphenols, trace elements and vitam
ins B, C
and E. Instead of causing sluggishness, the ice cream
increases mental agility and im
proves cognitive performance due to the com
bined effect of fats, xylitol and
caffeine, and theanine from the green tea. If M
acGyver w
ere to start his day with ice cream
, this would be it.
4 whole organic eggs
4 organic egg yolks
2 tsp Bourbon vanilla
2 tsp amla extract
1 tsp apple cider vinegar
Juice from half a lem
on
2 tbsp matcha pow
der
1 stick organic or grass-fed butter
100 g (½ cup) virgin coconut oil
50 g (1/4 cup) MC
T oil
120 g (4.25 oz) xylitol
100 g (½ cup) spring w
ater or coconut water
Pinch of unrefined sea salt
RE
CIPE
Melt butter and virgin coconut oil in a w
ater bath.
Mix all ingredients in a blender and pour into a
dish. Freeze overnight in a freezer or prepare in an
ice cream m
aker. Garnish w
ith bee pollen, coconut
shavings or sea buckthorn berries.
Sold to Fred Block Block (#GJ57M
BGL)
124
NU
TS
Nuts are extrem
ely nutrient dense and rich in protein,
good fatty acids, minerals, fiber and vitam
in E and B
complex. The flavor, consistency and convenience of
nuts has made m
any people increase the amount of
various nuts in their diet.
The regular consumption of nuts is associated w
ith a
significantly lower risk of coronary artery disease
393
and lower m
ortality in individuals at risk of
cardiovascular disease. 394 In 2013, a study spanning 30
years was published in the esteem
ed New
England
Journal of Medicine. The study show
ed that the
regular consumption of nuts w
as associated with a
longer lifespan and a lower m
ortality of cardiovascular
disease. 395 Individual studies have found nuts to
improve the antioxidant capacity of blood. 396
Health b
enefits of nuts:
• Com
pared to other nuts, pistachios are rich in
beta-carotene and lutein. The consum
ption of
pistachios has been found to have a positive effect on
the intestinal m
icrobiome. 397 Pistachios balance blood
sugar w
hen eaten with a high-carbohydrate m
eal. 398
Pistachios also reduce the oxidative stress of the
system
and improve cholesterol levels. 399
• Brazil nuts contain the m
ost selenium out of all
foods. Eating tw
o Brazil nuts per day m
ay raise the
selenium
level of the body as much as a 100 m
cg
selenium
tablet. 400
Sold to Fred Block Block (#GJ57M
BGL)
125
• Walnuts are exceptionally rich in short-chain om
ega-3
fatty acids (A
LA) and m
ay improve blood cholesterol
levels. 401
• Alm
onds m
ake an excellent snack that reduces
hunger and maintains a constant blood sugar
level. 402 In addition, almonds m
ay improve insulin
sensitivity403 and blood sugar regulation w
hen eaten
with carbohydrates. 404 They m
ay also lower the risk of
coronary artery disease. 405
• Pecan nuts improve the antioxidant capacity of the
body and inhibit the oxidation of LD
L cholesterol. 406
• Macad
amia nuts have the highest fat content of all
nuts. It contains nearly 80 %
fat, the majority of w
hich
consists of m
onounsaturated fatty acids. Macadam
ia
nuts have been found to have properties that
low
er oxidative stress, inflamm
ation and cholesterol
particularly in individuals w
ith markedly increased
cholesterol levels. 407 408
Approxim
ately 2 % of the population suffers from
a nut
allergy. It is the most com
mon cause of food allergy
induced death. From the epigenetic view
point, it is
interesting to note that mothers w
ho eat nuts during
pregnancy are less likely to have children with a nut
allergy. 409
Nuts contain relatively high levels of antinutrients that
may cause hypersensitivity and inhibit the absorption
of minerals (see the section titled “A
ntinutrients”).
Soaking and sprouting reduce these compounds, and
for instance a small am
ount (50 mg) of vitam
in C
Sold to Fred Block Block (#GJ57M
BGL)
126
taken concurrently prevents the negative effect of
inhibiting iron absorption. 410
Nuts sold at the superm
arket vary greatly in quality.
We recom
mend vacuum
-packed nuts that have been
protected from light. For fatty acid balance and health,
a handful of nuts is a good daily amount.
Favor:
• Walnuts
• Brazil nuts
• Macadam
ia nuts
• Alm
onds
• Pistachios
• Pecan nuts
• Cashew
nuts
A
void:
• Peanuts (in spite of the name, they are in fact
legum
es; rich in antinutrients)
• Hazelnuts (readily cause allergy)
• Roasted, rancid, salted and coated nuts
Making
nut milk
• 1 dl (½ cup) nuts (soaked)
• 4 dl (1 ½ cups) spring w
ater
Mix the ingredients in a blender until a
milky w
hite liquid forms. Strain using a
metal sieve or for exam
ple a nylon fruit
bag. If desired, you can flavor the liquid
with a teaspoonful of dom
estic honey or
genuine vanilla. Fresh nut milk can be used
as a beverage base or milk substitute.
RE
CIPE
+–
Sold to Fred Block Block (#GJ57M
BGL)
127
SEE
DS
Seeds are extremely nutrient dense. H
owever, they are
plant parts rich in compounds w
ith which the plants
attempt to protect the seeds from
damage. D
ue to
this, preprocessing seeds by soaking and sprouting is
fairly important for the absorption of nutrients and the
removal of harm
ful substances (antinutrients; see the
section titled “Antinutrients”).
Various seeds m
ay be used
to supp
lement the d
iet
dep
ending
on individ
ual needs:
• Linseeds counterbalance the spike in blood sugar after
a m
eal. They may also alleviate constipation. 411
• Chia seeds resem
ble linseeds in terms of nutritional
content. They are rich in m
anganese, magnesium
and
calcium
. 412
• Soaked chia seeds may im
prove performance in
endurance sports. 413
• Pumpkin seeds are rich in zinc, m
agnesium, fibers,
antioxidants and m
onounsaturared fatty acids. 414
• Shelled hemp seeds are a good source of protein
and m
agnesium. 415
Favor:
• Hem
p seeds (particularly the Finnish Finola variety)
• Chia seeds
• Linseeds
• Pumpkin seeds (particularly the A
ustrian Styrian
variety)
Additionally, m
any seeds have therapeutic value:
• Pine nuts (may increase the feeling of satiety) 416
• Grapefruit seeds (oil m
ade from seeds m
ay have
antim
icrobial properties) 417
• Milk thistle seeds (liver detoxifying and fat-reducing
effect) 418 419
• Pomegranate seeds (oxidative stress reducing and
nerve cells protecting effect) 420
• Cum
in seeds (antibacterial effect) 421
Use sp
aringly:
• Sunflower seeds
• Sesame seeds
+
Sold to Fred Block Block (#GJ57M
BGL)
128
SOA
KING
AN
D SPRO
UTIN
G
ALM
ON
DSoak overnightSprout 1–2 days
WA
LNU
TSoak 4 h B
RA
ZILNU
TD
o not soak
CH
ICK
PEA
Soak overnightSprout 2–3 days
LEN
TILS
Soak overnightSprout 2–3 days
MU
NG
BE
AN
Soak 1 day Sprout 2 days
WH
EA
TSoak overnightSprout 1–2 days
OA
TS
Soak overnightSprout 1–3 days
SPELT +
RY
ESoak overnightSprout 2–3 days
BAR
LEY
Soak overnightSprout 2 days
BU
CK
WH
EA
TSoak 15 m
ins Sprout 1–3 days
QU
INO
ASoak overnightSprout 1 day
MILLE
TSoak overnight
Sprout 1 day
RIC
ESoak overnight
Sprout 3–5 days
CO
RN
Soak overnightSprout 2–3 days
PEPIT
ASoak overnight
Sprout 1 day
HE
MP SE
ED
Do not soak
Sprout 2–5 days
SUN
FLOW
ER
SEE
DSoak overnight
Sprout 1–2 days
FLAX
SEE
DSoak overnight
ALFA
FASoak overnight
Sprout 4–6 days
SESA
ME
SEE
DSoak overnight
Sprout 1 day
PINE
NU
TD
o not soak
PISTACH
IOD
o not soak
MA
CA
DA
MIA
Do not soak
CA
SHE
WSoak 2h
PEC
AN
Soak overnight
SOA
K &
SPRO
UT
Seeds, nuts, cereals and beans contain agents that interfere w
ith nutrient absorption or may
otherwise cause health problem
s. Soaking and sprouting inhibit thefunction of these agents.
Sold to Fred Block Block (#GJ57M
BGL)
129
LEG
UM
ES
The fruit produced by legumes are called pods. The
term legum
e generally includes various pea plants and
cultivated legumes (legum
inous plants). The most com
-
monly used legum
es include soybeans, peanuts, lentils,
chickpeas, beans and peas. More than 40 %
of legumes
are dried for human consum
ption. The vast majority of
the world’s bean production takes place in India. 422
Interest in the consumption of legum
es has piqued
especially given the increasing popularity of vegetarian
diets. Supermarkets stock products like precooked
lentils, chickpeas, mung beans, string beans and
various soy products such as tofu.
Legumes are quite rich in agents intended for the
protection of their seeds, i.e. antinutrients. These
include trypsin inhibitors, lectins (particularly in
soybeans), saponins and glycosides (see the section
titled “Antinutrients”). For this reason, legum
es
should always be soaked and cooked thoroughly.
Soaking legumes also reduces their level of galactan
– an agent which for m
any people causes flatulence. 423
A particularly harm
ful legume is the red kidney bean
which is rich in lectins. C
onsuming beans that have
been soaked but not cooked (in salads for example)
typically causes gastrointestinal symptom
s.
In terms of their am
ino acid composition, the protein
structure of legumes is sim
ilar to that of animal protein
although it lacks sulfur-containing amino acids. For
example, broad beans contain up to 35 %
protein. They
are also rich in slowly digestible starch, som
e of which
is resistant starch that is useful for the intestinal bacte-
rial strain. Broad beans have been farm
ed in Finland
since the 7th century. The Finnish broad beans are not
very rich in glycosides because of the successful cultiva-
tion. 424
A large proportion of beans belongs to the
Phaseolus vulgaris genus. These beans are very rich
in antinutrients. This genus includes black beans,
cannellini beans, green beans, kidney beans, pinto
beans and white beans, am
ong others. 425
Sold to Fred Block Block (#GJ57M
BGL)
130
The health imp
acts of legum
esD
espite the antinutrients, legumes also have health
benefits. Population-based epidemiological studies
have yielded results of legumes reducing the risk
of intestinal cancer. 426 Hypotheses for the cause
include the effects of isoflavones, lignans and various
antioxidants in the intestine. 427Another interesting
finding is the effect of legumes (w
ith the exception of
soybeans) in reducing silent inflamm
ation (lower high-
sensitivity CRP). 428 The regular use of these legum
es
may also low
er blood pressure429 and cholesterol
levels. 430
Many bean lectins, particularly PH
A (phytohem
agglutinin),
are not completely destroyed even after soaking
and prolonged cooking. 431 The more PH
A-rich the
individual’s diet, the more problem
s it may cause,
particularly in the intestine. PHA
has been found to
damage the surface of the intestine and to cause silent
inflamm
ation. 432 433 The soybean lectin (SBA
) and peanut
lectin (PNA
) also permeate the intestinal w
all 434 and,
based on animal tests, m
ay present a predisposing
factor for atherosclerosis. 435
Pea and lentil lectins appear
to be significantly less harmful
compared to the lectins of
other legumes.
Reasons to avoid
soy prod
ucts: 436
• Soy is rich in phytates that inhibit the absorption of
nutrients in the intestine
437
• Trypsin inhibitors in soy may im
pair the absorption of
proteins
• Phytoestrogens in soy may interfere w
ith normal
fem
ale hormonal activity, 438 im
pair thyroid function, 439
cause infertility in m
en440 and prom
ote the
developm
ent of breast cancer in wom
en441 442
• Soy and the saponins of soy protein in particular may
dam
age the intestine and increase its permeability
to various other toxins; 443 saponins m
ay also cause the
hem
olysis (rupturing) of red blood cells444
• As m
uch as 94 % of A
merican soy and m
ore than half
of soy w
orldwide is genetically m
odified (GM
O) 445
Sold to Fred Block Block (#GJ57M
BGL)
131
Prepare b
eans/lentils as follows:
• Soak the beans overnight (12 hours minim
um)
– Tip: boost the lectin rem
oval process by adding
baking soda to the soaking w
ater
• Rinse the beans thoroughly
• Cook in boiling w
ater for a minim
um of 30 m
inutes
(som
e beans require significantly longer,
90 m
inutes)
Other useful m
ethods for p
reparing
beans:
• Sprouting (for example m
ung bean sprouts)
– Significantly reduces the lectin and saponin
content of beans
• Fermenting (for exam
ple, tempeh m
ade from soy;
see the section titled “A
ntinutrients”)
– D
oes not remove all lectins how
ever
Favor:
• Lentils (particularly beluga lentils and red lentils)
• Mung beans, soaked and sprouted
• Fermented tem
peh and natto (non-GM
O)
• Green peas and broad beans, boiled and peeled
A
void:
• Soybeans and tofu
• Beans (particularly kidney beans)
• Peanuts
• Soy protein and other soy products
– +
Sold to Fred Block Block (#GJ57M
BGL)
132
FUN
GI
Fungi have been used for medicinal purposes for
thousands of years, particularly in Asia. M
ore than 2000
years ago the Greek physician D
ioscorides (approx.
40–90 CE) described in his classic w
ork De M
ateria
Medica the use of agarikon (fom
itopsis officinalis) in the
treatment of tuberculosis. It is only in recent decades
that the medicinal use of fungi has significantly
increased in the Western w
orld. There are known to be
approximately 140,000 fungus species in the w
orld, only
10 % of w
hich have been scientifically studied.
Generally speaking fungi are rich in fiber, vitam
ins
B1, B
2, B3 and D
2, selenium, antioxidants and
protein. Many fungi contain an am
ino acid called
l-ergothioneine which has been found to protect cells
and DN
A from
damage. L-ergothioneine stim
ulates
the breakdown of sugar and im
itates carnitine in its
ability to carry fat to cell mitochondria. 446 In addition,
many fungi contain com
pounds that have been
shown to have antibacterial, antiviral, antifungal, anti-
inflamm
atory, pain relieving and cancer cell destroying
properties. 447
In his book Fungal Pharmacy (2011) fungus expert
Robert Rogers states that fungi have been shown to
have at least 126 distinct medicinal properties. 448
In nature fungi compete w
ith various microbes, w
hich
is why they specialize in producing antibiotics and
various antiviral compounds. The m
edicinal properties
of fungi are usually polysaccharides or triterpenes. In
addition to these, the glycoproteins, sterols and certain
metabolic products (such as antibiotics) of fungi are
utilized for medicinal purposes. N
umerous im
portant
medicines such as penicillin, griseofulvin,
erythromycin and cyclosporin w
ere
isolated from fungi.
The most w
ell-known m
edicinal fungi
are shiitake (lentinula edodes), lingzi
mushroom
s (ganoderma lucidum
), turkey
tail (trametes versicolor), caterpillar
fungus (ophiocordyceps sinensis), hen-
of-the-woods (grifola frondosa), agaricus
blazei, matsutake (tricholom
a matsutake), lion’s m
ane
(hericium erinaceus) and chaga m
ushrooms (inonotus
obliquus). 449
Sold to Fred Block Block (#GJ57M
BGL)
133
It is important to pick fungi from
an unpolluted site.
Fungi collect heavy metals and radioactive cesium
from the environm
ent. There are also deadly poisonous
varieties such as the European destroying angel, the
livid entoloma, lethal w
ebcaps and the funeral bell
mushroom
. 450 To minim
ize toxins and cesium, m
any
fungi (such as the morel) should be boiled tw
ice and
then rinsed in cold water. 451 If you don’t recognize a
fungus – leave it be.
Favor:
• Double extracted (w
ater and alcohol
extracted) m
edicinal mushroom
powders
• Using m
ushrooms w
ith medicinal
properties in cooking
• Shiitake and oyster mushroom
s are well
suited for stew
s and soups
• Utilizing chaga tea in soup, rice cooking
w
ater and as a coffee base
• Extract powders m
ixed with chocolate, coffee,
tea or sm
oothies
• Yellowfoot
• Golden chanterelle (rich in
vitam
in D2)
• Black chanterelle (rich in
nutrients)
• Penny bun (rich in selenium,
protein and fibers)
• Russula mushroom
s (yellow
sw
amp russula, russula decolorans, russula paludosa,
darkening brittlegill, crab brittlegill, bare-toothed
russula)
• Oyster m
ushrooms (im
proves fat metabolism
and
im
munity)
• Ceps (orange birch bolete, bay bolete, slippery jack,
penny bun, velvet bolete)
• Milkcaps (northern bearded m
ilkcap, weeping
m
ilkcap, red hot milkcap, orange m
ilkcap, candy cap,
com
mon lactarius, false saffron m
ilkcap, ugly milkcap,
w
oolly milkcap, lactarius lignyotus)
• Sheep polypore, terracotta hedgehog, sheathed
w
oodtuft, morel, gypsy m
ushroom, slim
y spike-cap,
pestle puffball, scaly tooth
+
Sold to Fred Block Block (#GJ57M
BGL)
134
A
void:
• The excessive daily consumption of fungi (m
any
edible m
ushrooms such as the yellow
knight, penny
bun, russula m
ushrooms, chanterelle and sheep
polypore strain the kidneys and liver) 452
• Fungi that irritate the digestive tract when uncooked
(alw
ays cook the orange birch bolete, rough-
stem
med bolete, honey fungi, shiitake, shaggy
parasol, clouded agaric and tangy m
ilkcaps and
russulas)
• Poisonous fungi
• Consum
ing the comm
on ink cap or club-footed
clitocybe w
ith alcohol
• Fungi that have collected a lot of heavy metals or
radioactive cesium
Vitam
in D from
mushroom
s
Dry m
ushrooms in sunlight to m
ultiply their
vitamin D
content. Studies conducted on
shiitake mushroom
s indicate that 100 g (3.5
oz) of fresh mushroom
s, after having been
placed in the sun for 12 hours, contained
an additional 1000 µg vitamin D
2. 453
TIP
–
Sold to Fred Block Block (#GJ57M
BGL)
135
WATE
R
On average, hum
an beings are 65 % w
ater. Dehydration
at only a few percentage points significantly im
pairs our
general ability to function. Fluid balance regulation is
one of our most im
portant regulatory mechanism
s.
Water is essential for life. The significance clean
drinking water to health of therefore cannot be
overemphasized. Fresh w
ater is currently a diminishing
natural resource due to intensive farming am
ong other
things. As m
uch as 70 % of the w
orld’s water resources,
including groundwater, is used in agriculture. 454 The
United N
ations has estimated that the consum
ption of
fresh water has increased six-fold in the past century.
If the raw w
ater (groundwater) contains organic m
atter
suitable as a source of impurities (surface w
ater),
impurities rem
ain in the water even after disinfection.
Finland was one of the first countries to change its
water purification system
s when the negative effects of
trihalomethane, furans and brom
ate became present. 455
When the disinfection m
ethod used is the most
comm
on one – chlorination – various chlorinated
compounds form
as chlorine and organic matter react.
Dem
ographic studies have indicated that the long-
term use of drinking w
ater made from
surface water
through chlorination may increase the risk of cancer. 456
How
ever, the advantages of chlorination outweigh the
disadvantages.
Even 50+ year old w
ater pipes can leak impurities into
the drinking water. 457 458 In som
e rural areas, tap water
contains excess calcium w
hich can be a predisposing
factor for coronary artery disease and heart attacks. 459 In
drilled wells, a brow
n color and unpleasant odor may be
a sign of high iron and manganese levels in the w
ater.
Sold to Fred Block Block (#GJ57M
BGL)
136
Official guidelines recom
mend drinking a m
inimum
of
1–1.5 litres (35–50 fl oz), preferably 2–3 litres (70–100 fl
oz) of water per day. The w
ater requirement increases
with rising tem
peratures. The elderly should also drink
more fluids due to the im
paired ability of their kidneys
to filter urine. 460
Store water in a dark glass bottle w
henever possible.
Avoid plastic as harm
ful compounds such as B
PA
or phthalates may dissolve in the liquid. These
compounds are present in plastic bottles m
arked with
a recycling symbol w
ith the number 03 or 07. These
compounds have a harm
ful effect on the functions of
the endocrine system. 461
Favor:
• Naturally flow
ing spring water (m
icrobiologically
tested)
• Liquid contained by plants (freshly squeezed juice,
sap, coconut w
ater)
• Drilled w
ell water and w
ell water
• Purified tap water (separate filtering device or
filter attached to tap)
• Reverse osmosis (RO
), activated carbon filtering,
ion exchange
• High quality spring w
ater or mineral w
ater sold in
glass bottles (such as Pellegrino)
A
void:
• Water packaged in plastic bottles
• Vitamin-enriched w
ater
• Carbonated w
ater
• Tap water
RE
CO
MM
EN
DA
TIO
NLocate drinkable spring w
ater around the world:
ww
w.findaspring.com
–
+
Sold to Fred Block Block (#GJ57M
BGL)
137
CO
FFEE
Finns drink the most coffee in the w
orld, 12 kg (26
pounds) per capita. The other Nordic countries are also
frequent coffee drinkers. US consum
es a little over 4 kg
(9 pounds). Besides oil, coffee is the w
orld’s most
actively traded comm
odity. Due to this, large quantities
of various pesticides are used to maxim
ize production.
It is worthw
hile to invest in high quality coffee and a
proper preparation method, if only for a m
ore satisfying
coffee experience.
Coffee that has been grow
n and processed with quality
in mind contains few
er harmful substances and m
ore of
coffee’s beneficial active agents, and in terms of ethics,
it is a significantly more sustainable choice com
pared
to intensively produced coffee. High quality coffee has
a well-rounded flavor in that its arom
as need not be
covered up with sugar, m
ilk or cream.
For most people, reasonable coffee consum
ption (3–4
cups per day) is compatible w
ith a healthy, balanced
diet and an active lifestyle. 462 According to a com
pre-
hensive meta-analysis, reasonable coffee consum
ption
may extend the life span, low
er the risk of developing
type 2 diabetes463 and cardiovascular diseases
464 and
prevent premature death from
these illnesses. 465 The
health benefits of coffee are most likely due to the
anti-oxidants it contains, such as polyphenols. Indeed,
more than 1,000 antioxidant com
pounds have been
found in coffee, even more than in green tea and
cocoa. 466
A great m
any people enjoy coffee daily due to its
effects in stimulating and lifting the spirits. H
owever,
the effects of coffee depend on one’s genetic makeup.
For example, the C
YP1A2 gene affects the body's
ability to remove caffeine from
the system, and the VD
R
gene is associated with caffeine’s negative
effects on bone health. For these
reasons the same am
ount of caffeine
may have a different effect on different
individuals. 467
Sold to Fred Block Block (#GJ57M
BGL)
138
The primary risk factors in term
s of harmful substances
affecting the quality of coffee are pesticides and
mycotoxins. W
ater washing significantly reduces the
level of mycotoxins
468 and when w
ashed properly, the
ochratoxin A (O
TA) level of green coffee beans is
reduced by 90 %. 469 In addition to this, roasting
destroys 69–96 % of the rem
aining OTA
. 470
According to a report published by the Finnish
Custom
s in 2012, 12 % of the tested instant coffees,
roasted coffees and hot chocolate drinks were
contaminated by m
ycotoxins (OTA
, aflatoxins). 471 Coffee
producers have been actively involved in initiatives
to guide farmers in im
plementing the best farm
ing
practices to minim
ize the risk of mold. 472
The Biohacker's C
offee Manifesto:
• Favor organic or pesticide-free, pure coffee
• Favor single origin coffee
• Favor water w
ashed coffee
• Favor coffee grown at high altitudes
• Avoid instant coffee, blends of several coffee bean
varieties and coffee grow
n near sea level (at low
altitudes)
• Time coffee consum
ption at a sensible part of
your day
• Purchase freshly roasted coffee
• Grind the coffee beans yourself im
mediately
before use
• Use a m
etal filter, avoid paper filters processed
w
ith chemicals
• Only purchase coffee for a m
aximum
of two w
eeks’
consum
ption at a time
• Alw
ays store coffee in an airtight container
• Use kitchen scales to m
easure the ratio of coffee
to w
ater
• Do not over brew
coffee
• Do not add sugar, m
ilk or cream to coffee
Sold to Fred Block Block (#GJ57M
BGL)
139
RE
CIPE
Biohacker C
offee• 16 g (½
oz) high quality coffee beans (grown in
volcanic soil at high altitude, C
entral Am
erican,
w
ater washed, organic)
• 250 ml (1 cup) nearly boiling spring w
ater or
filtered tap w
ater (91 °C / 196°F)
• 1 tbsp grass-fed butter
• 1 tbsp MC
T oil or cold pressed coconut oil
• Add flavor w
ith a pinch of genuine vanilla
and/or chaga extract
First grind the beans into a fine powder. B
ring the
filtered water to a nearly boiling tem
perature 91 °C
(196 °F) and preheat the blender, glass, thermos and
other accessories with hot w
ater. Place the ground
coffee and flavorings (vanilla, chaga extract) into a
suitable preparation device (Aeropress, C
hemex,
French press, dripper) and pour one half of the water in.
Mix for 10 seconds and add the rem
aining water. B
rew
for 1–4 minutes. Rem
ove hot water from
the blender.
Add butter, M
CT oil and other ingredients into the
blender. Press the coffee through the filter. Add the
coffee into the blender and mix at full speed for 15–20
seconds.
Pour the foamy coffee into a glass or a therm
os. Sip
slowly. The fats in the coffee provide a constant source
of energy and improve cognitive functions. A
lso try
adding theanine (200 mg).
Sold to Fred Block Block (#GJ57M
BGL)
140
TEA
Tea is the world's second m
ost popular drink after
water. Tea is typically prepared by infusing the leaves
of the tea bush (camellia sinensis). The history of tea
begins during the Shang dynasty of China (1766–1050
BC
E) when it w
as used predominantly for m
edicinal
purposes. In the Him
alayan region of India, tea has
been used for medicinal purposes for nearly as long.
Tea only arrived in Europe at the turn of the 17th
century and later became an extrem
ely popular
beverage particularly in England.
Turkish people drink the most tea in the w
orld, over
7 kg (15 pounds) per capita. Other big tea drinking
countries are Ireland and the United Kingdom
. These
countries also prefer tea over coffee.
Teas are typically divided into various categories
depending on the processing method. The six
most com
mon ones are green tea, yellow
tea, white
tea, oolong tea, black tea and post-fermented tea.
Beverages m
ade from leaves other than tea leaves are
called herbal teas. The medicinal
use of tea beverages is extensive
particularly in oriental cultures.
Tea quality depends on several
factors. Aside from
processing methods, the prim
ary
factor is the age of the tea leaves. The most valued tea
leaves are the new leaves grow
ing near the blooms.
Tea leaves are rich in polyphenols such as flavonoids,
theanine, theophylline, epigallocatechin-3-gallate
(EGC
G) and other catechins. In addition, all teas
contain 30–90 mg of caffeine per cup depending on
the tea variety and the preparation method. 473
Each tea variety has a specific brewing tim
e and
temperature as w
ell as traditional methods of use.
These have a significant impact on the antioxidants,
caffeine, flavor and health benefits of the tea. We
encourage you to consult expert tea traders regarding
optimal brew
ing times and tem
peratures. Some tea
varieties may contain heavy m
etals and environmental
toxins, 474 highlighting the importance of ensuring that
the tea is of high quality.
Sold to Fred Block Block (#GJ57M
BGL)
141
Green tea
Green tea is probably one of the m
ost studied tea
varieties for its health benefits. Green tea contains
30–40 % of w
ater-soluble polyphenols, whereas black
tea contains only 3–10 %. G
reen tea is also suitable
for individuals sensitive to caffeine due to its theanine
content. Theanine reduces the unpleasant side effects
of caffeine. 475
Com
prehensive meta-analysis studies reveal that the
consumption of green tea low
ers blood pressure, 476 477
the levels of both total cholesterol and LDL
cholesterol 478 as well as the levels of fasting glucose
and long-term glucose. 479 G
reen tea may also slow
down the deterioration of m
emory. The optim
al health
benefits are achieved by drinking 5–7 cups per day. 480
An alternative to drinking abundant am
ounts of tea is
to take green tea extract with a m
eal. Extracts may also
have a slimm
ing effect. 481
Yerba m
atéYerba m
até (mate) is a beverage prepared by steeping
the leaves and new shoots of the m
até tree. Technically,
it is not a variety of tea but it is used in very similar
manner. Traditionally, m
até has been used as an
empow
ering drink amongst the indigenous people of
South Am
erica.
Yerba maté is rich in antioxidants such as quercetin,
vitamins B
and C and m
inerals (magnesium
, potassium,
zinc). 482 Maté also contains several stim
ulating and
refreshing xanthines that are also present in coffee
(caffeine), tea (theophylline) and cocoa (theobromine).
Maté m
ay improve m
ood, 483 lower cholesterol levels
and reduce inflamm
ation484 as w
ell as balance
blood sugar. 485
Pu-erh-teaPu-erh tea is black tea originating from
the Yunnan
province in China. The ferm
enting method used to
prepare pu-erh tea makes it significantly healthier than
black tea. The longer pu-erh tea is fermented and
matured, the m
ore valuable and healthy it is. Some
pu-erh tea cakes may keep for nearly a hundred years.
Pu-erh tea is rich in polysaccharides, polyphenols and
statins. Pu-erh tea contains slightly less caffeine than
coffee. Several animal tests have found positive effects
Sold to Fred Block Block (#GJ57M
BGL)
142
on fat metabolism
486 and body weight. 487 488 Very little
pu-erh tea research has been conducted on humans.
Oolong
teaIn term
s of oxidation level, oolong tea is placed
between green tea (little oxidation) and black tea
(great oxidation). The same leaves can be used for
steeping several times. Like green tea, oolong tea
is rich in antioxidants such as various catechins and
polyphenols.
A com
prehensive Chinese dem
ographic study showed
that the long-term use of oolong tea w
as associated
with im
proved blood lipid values. 489 Unlike other tea
varieties, oolong tea also has a strong effect on the
GA
BA
-A receptors (calm
ing neurotransmitter). 490
White tea
White tea com
es from C
hina, particularly the Fujian
province. It is a lightly oxidized, fine tea prepared from
the young buds and leaves of the tea bush. White tea
is significantly more rare than the other tea varieties.
White tea contains slightly m
ore caffeine and equal
amounts of antioxidants com
pared to green tea. 491
The consumption of w
hite tea may reduce the risk of
stroke492 and based on anim
al tests, also prevent athero-
sclerosis. 493 494 Used topically, w
hite and green tea may
protect the skin from the harm
ful UV rays of the sun. 495 496
Favor:
• Pu-erh tea after a high-fat meal (85–95 °C
/ 185–203 °F,
12 seconds to 2 m
inutes)
• Green tea w
ith meals (60–80 °C
/ 140–176 °F,
1–2 m
inutes)
• Sencha, matcha, gyokuro
• Oolong tea w
hen you need to concentrate (80–85 °C /
176–185 °F), 2–3 m
inutes)
• White tea (60–70 °C
/ 140–158 °F, 1–2 minutes)
• Yerba maté w
hen working (60–70 °C
/ 140–158 °F,
3–5 m
inutes)
• Caffeine-free herbal tea in the evening
A
void:
• Bagged tea
• Prepared ice teas
• Black tea
• Using m
ilk with tea (inhibits the health benefits
of flavonoids) 497
– +
Sold to Fred Block Block (#GJ57M
BGL)
144
ALC
OH
OL
The highest consumption rates of alcohol seem
to be
concentrated in Europe. The highest rates can be seen
in countries like Estonia, Belarus, Lithuania, the C
zech
Republic, Austria and Ireland, w
ith each around 11–14
liters (3–6 gallons) per capita. Drinking per se and high-
volume drinking are consistently m
ore prevalent among
men than w
omen.
According to the W
orld Health O
rganization, the use of
alcohol is associated with at least 60 different illnesses.
Health hazards are present even w
ith short-term liberal
use, but severe hazards become apparent particularly
with long-term
use. The main alcohol illnesses are
alcohol dependency, alcohol poisoning, alcohol
psychosis, alcoholic liver diseases and pancreatitis.
In addition to these, the liberal consumption of
alcohol causes neurological and psychiatric illnesses,
hormonal and nutritional disorders, degeneration
of the heart muscle, arrhythm
ia, cancer and blood
diseases. As m
any as 6 % of all deaths are caused by
alcohol. Alcohol-related causes of death are the single
most significant factor in 15–64 year old m
en, ahead
of coronary artery disease. Alcohol plays a role in a
significant number of accidents. 498
Based on a com
prehensive demographic study report,
the moderate use of alcohol (2 units of alcohol for m
en
Hang
over Cure
• 3 dl (1 1/4 cups) coconut water
• 1 avocado
• Juice from half a lem
on
• Couple of broccoli buds
• 300 mg red ginseng
• 2–3 cm (1 inch) piece of ginger
• 2 egg yolks
• 1 tsp chlorella
• Sea salt and fenugreek, to taste
Blend the ingredients in a blender.
RE
CIPE
Sold to Fred Block Block (#GJ57M
BGL)
145
and 1 unit for wom
en per day) in good company m
ay
reduce the risk of dementia and the im
pairment of
cognitive functions. The study also found that heavy
use (more than 3–5 units per day) increased the risk of
dementia and im
paired cognitive functions. 499
Favor:
• Total abstinence or consuming sm
all amounts
infrequently in good com
pany
• Hom
emade tinctures
• Hom
emade herbal beer and alcoholic cider
• Clear liquor packaged in glass bottles (potato-based
is preferable to grain-based)
– Russian Standard Im
peria
– Russian Standard Platinum
• Gin, tequila and w
hiskey
• Cham
pagne
• Biodynam
ic red wines (low
tannin, no added sulfites)
• Natural w
ines
• Classic herbal beers (H
ealing Herbal B
eers, Buhner)
• Sprite or equivalent lemon and lim
e mixer
(accelerates the breakdow
n of acetaldehyde in the
system
) 500
A
void:
• Lagers
• Colored liquors
• Alcoholic ciders sw
eetened with sugar
• The consumption of carbonated beverages m
ixed
w
ith alcohol (increases the absorption of alcohol)
Hangover sym
ptoms are caused by acetaldehyde poisoning. The breakdow
n of acetaldehyde into harm
less acetic acid requires glutathione tripeptide (glutamic acid, cysteine and glycine).
THE B
REAKD
OW
N O
F ALC
OH
OL IN
THE SYSTEM
–
+
Ethanol(C
H O
)A
cetaldehyde(C
H O
)26
24
Acetic acid(C
H O
)22
4
Water (H
O)
2
carbon dioxide(C
O )2
&
Sold to Fred Block Block (#GJ57M
BGL)
146
Beating
a Hang
over
The suggestions are based on supporting natural
glutathione levels, removing toxic substances and
restoring nutrients depleted by alcohol.
Before use:
• Eat meat (particularly turkey) w
ith turmeric
and egg yolks (am
ino acids)
• 5–10 g (0.17–0.35 oz) chlorella
• Vitamin B
1 and alpha lipoic acid
• 100 mg glutathione (preferably
in a liposom
al form)
• Milk thistle (silym
arin) and
fenugreeka
501
TIP
During
:
• 500 mg vitam
in C and 200 m
g N-acetylcysteine
(N
AC
) before each alcoholic drink
• 300 mg ginseng (accelerates the exit of
acetaldehyde from
the system) 502
• A glass of w
ater with each alcoholic drink
After:
• Vitamin B
complex
• Electrolytes (unrefined sea salt and coconut
w
ater)
• Broccoli (sulforaphane elim
inates toxic
acetaldehyde from
the body) 503
• Fresh ginger (2–3 cm / 1-inch piece
prevents nausea)
Before b
ed:
• 1–2 g (0.03–0.07 oz) activated carbon
(binds the toxins form
ed)
Sold to Fred Block Block (#GJ57M
BGL)
147
Sources1 Ryynänen, J. (2014). Pleiotropy of vitam
in D-m
ediated gene regulation. Väitöskirja, Itä-Suomen yliopisto. [date of reference: 21.9.2014]
2 Loftas, T. et al. (1995). Dim
ensions of Need. A
n Atlas of Food and A
griculture. Food and Agriculture O
rganization of the United N
ations.
3 Andrade, A
. & G
reene, G. &
Melanson, K. (2008). Eating slow
ly led to decreases in energy intake within m
eals in healthy wom
en. Journal of the A
cademy of N
utrition and Dietetics 108 (7): 1186–1191.
4 King, B. &
Townsend-N
icholson, A. (2008). Involvem
ent of P2Y1 and P2Y11 purinoceptors in parasympathetic inhibition of colonic sm
ooth muscle.
Journal of Pharmacology and Experim
ental Therapeutics 324 (3): 1055–1063.
5 Abels, J. et al. (1959). The physiologic m
echanism of vitam
in B12 absorption. A
cta Medica Scandinavica 165: 105–113.
6 Kassarjian, Z. & Russell, R. (1989). H
ypochlorhydria: a factor in nutrition. Annual Review
s Nutrition 9: 271–285. Review
.
7 Lau, Y. & A
hmed, N
. (2012). Fracture risk and bone mineral density reduction associated w
ith proton pump inhibitors. Pharm
acotherapy 32 (1): 67–79.
8 Tennant, S. et al. (2008). Influence of gastric acid on susceptibility to infection with ingested bacterial pathogens. Infection and Im
munity 76 (2): 639–645.
9 Sarzynski, E. & Puttarajappa, C
. & Xie, Y. &
Grover, M
. & Laird-Fick, H
. (2011). Association betw
een proton pump inhibitor use and anem
ia: a retrospective cohort study. D
igestive Diseases and Sciences 56 (8): 2349–2353.
10 Lam, J. &
Schneider, J. & Zhao, W
. & C
orley, D. (2013). Proton pum
p inhibitor and histamine 2 receptor antagonist use and vitam
in B12 deficiency.
The Journal of The Am
erican Medical A
ssociation 310 (22): 2435–2342.
11 Theisen, J. et al. (2000). Suppression of gastric acid secretion in patients with gastroesophageal reflux disease results in gastric bacterial overgrow
th and deconjugation of bile acids. Journal of G
astrointestinal Surgery 4 (1): 50–54.
12 Helander, H
. & Fändriks, L. (2014). Surface area of the digestive tract – revisited. Scandinavian Journal of G
astroenterology 49 (6): 681–689.
13 Svendsen, A. (2000). Lipase protein engineering. Biochim
ica et Biophysica Acta 1543 (2): 223–238. Review
.
14 Yao, Z. & B
amji-M
irza, M. (2011). A
nimal lipid biochem
istry. Phospholipases. The AC
OS Lipid Library. [date of reference: 11.9.2014]
15 Irving, M. &
Catchpole, B
. (1992). AB
C of colorectal diseases. A
natomy and physiology of the colon, rectum
, and anus. British Medical Journal
304 (6834): 1106–1108. Review.
16 Miller, T. &
Wolin, M
. (1996). Pathways of acetate, propionate, and butyrate form
ation by the human fecal m
icrobial flora. Applied and Environm
ental M
icrobiology 62 (5): 1589–1592.
17 Bollinger, R. et al. (2007). B
iofilms in the large bow
el suggest an apparent function of the human verm
iform appendix. Journal of Theoretical Biology
249 (4): 826–831. Review.
Sold to Fred Block Block (#GJ57M
BGL)
148
18 Im, G
. et al. (2011). The appendix may protect against C
lostridium difficile recurrence. C
linical Gastroenterology and H
epatology 9 (12): 1072–1077.
19 Vons, C. et al. (2011). A
moxicillin plus clavulanic acid versus appendicectom
y for treatment of acute uncom
plicated appendicitis: an open-label, non-inferiority, random
ised controlled trial. The Lancet 377 (9777): 1573–1579.
20 Jussila, A. et al. (2013). H
igh and increasing prevalence of inflamm
atory bowel disease in Finland w
ith a clear North-South difference.
Journal of Crohns &
Colitis 7 (7): e256–262.
21 Hou, J. &
Abraham
, B. &
El-Serag, H. (2011). D
ietary intake and risk of developing inflamm
atory bowel disease: a system
atic review of the literature.
The Am
erican Journal of Gastroenterology 106 (4): 563–573. Review
.
22 Fasano, A. (2011). Leaky gut and autoim
mune diseases. C
linical Reviews in A
llergy and Imm
unology 42 (1): 71–78.
23 Olendzki, B
. et al. (2014). An anti-inflam
matory diet as treatm
ent for inflamm
atory bowel disease: a case series report. N
utrition Journal 13: 5.
24 Drago, S. et al. (2006). G
liadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal m
ucosa and intestinal cell lines. Scandinavian Journal of G
astroenterology 41 (4): 408–419.
25 Festen, E. et al. (2011). A m
eta-analysis of genome-w
ide association scans identifies IL18RAP, PTPN
2, TAG
AP, and PU
S10 as shared risk loci for Crohn’s
disease and celiac disease. PLoS Genetics 7 (1): e1001283.
26 Herfarth, H
. & M
artin, C. &
Sandler, R. & Kappelm
an, M. &
Long M. D
. (2014). Prevalence of a gluten-free diet and improvem
ent of clinical symptom
s in patients w
ith inflamm
atory bowel diseases. Inflam
matory Bow
el Diseases 20 (7): 1194–1197.
27 Batterham
, R. et al. (2003). Pancreatic polypeptide reduces appetite and food intake in humans. The Journal of C
linical Endocrinology and Metabolism
88 (8): 3989–3992.
28 Kunitz, M. (1939). Form
ation of trypsin from crystalline trysinogen by m
eans of enterokinase. Journal of General Physiology 22 (4): 429–446.
29 Hall, J. (2010). G
uyton and Hall Textbook of M
edical Physiology. Philadelphia: Saunders.
30 European Association for the Study of Liver. (2012). EA
SL clinical practical guidelines: managem
ent of alcoholic liver disease. Journal of Hepatology
57 (2): 399–420.
31 Chida, Y. &
Sudo, N. &
Kubo, C. (2006). D
oes stress exacerbate liver diseases? Journal of Gastroenterology and H
epatology 21 (1 Pt 2): 202–228. Review.
32 Milic, S. &
Lulic, D. &
Štimac, D
. (2014). Non-alcoholic fatty liver disease and obesity: biochem
ical, metabolic and clinical presentations.
World Journal of G
astroenterology 20 (28): 9330–9337.
33 Pandit, A. &
Sachdeva, T. & B
afna, P. (2012). Drug-Induced H
epatotoxicity: A Review
. Journal of Applied Pharm
aceutical Science 02 (05): 233–243.
34 Pak, E. & Esrason, K. &
Wu, V. (2004). H
epatotoxicity of herbal remedies: an em
erging dilemm
a. Progress in Transplantation 14 (2): 91–96. Review.
35 Michalopoulos, G
. (2007). Liver regeneration. Journal of Cellular Physiology 213 (2): 286–300. Review
.
Sold to Fred Block Block (#GJ57M
BGL)
149
36 Grant, D
. (1991). Detoxification pathw
ays in the liver. Journal of Inherited Metabolic D
isease 14 (4): 421–430. Review.
37 Ellis, H. (2011). A
natomy of the gallbladder and bile ducts. Surgery (O
rford) 29 (12): 593–596.
38 Schmidt, D
. et al. (2010). Regulation of bile acid synthesis by fat-soluble vitamins A
and D. The Journal of Biological C
hemistry 285 (19): 14486–14494.
39 Houten, S. &
Watanabe, M
. & A
uwerx, J. (2006). Endocrine functions of bile acids. The EM
BO Journal 25 (7): 1419–1425. Review
.
40 Ikemoto, S. et al. (1997). C
holate inhibits high-fat diet-induced hyperglycemia and obesity w
ith acyl-CoA
synthetase mRN
A decrease.
Am
erican Journal of Physiology 273 (1 Pt 1): E37–45.
41 Hofm
ann, A. (1999). The continuing im
portance of bile acids in liver and intestinal disease. Archives of Internal M
edicine 159 (22): 2647–2658. Review.
42 Walcher, T. et al. (2009). Vitam
in C supplem
ent use may protect against gallstones: an observational study on a random
ly selected population.
BMC
Gastroenterology 9: 74.
43 Koppisetti, S. et al. (2008). Reactive oxygen species and the hypomotility of the gall bladder as targets for the treatm
ent of gallstones with m
elatonin:
a review. D
igestive Diseases and Sciences 53 (10): 2592–2603.
44 National Institutes of H
ealth. (2012). Hum
an Microbiom
e Project defines normal bacterial m
akeup of the body. Bethesda: N
ational Hum
an Genom
e
Research Institute. [date of reference: 26.8.2014]
45 Ley, R. & Peterson, D
. & G
ordon, J. (2006). Ecological and evolutionary forces shaping microbial diversity in the hum
an intestine. C
ell 124 (4): 837–848. Review.
46 Guarner, F. &
Malagelada, J. (2003). G
ut flora in health and disease. The Lancet 361 (9356): 512–519. Review.
47 Sonomoto, K. &
Yokota, A. (2011). Lactic A
cid Bacteria and Bifidobacteria. Current Progress in A
dvanced Research. Norfolk: C
aister Academ
ic Press.
48 Wong, J. &
de Souza, R. & Kendall, C
. & Em
am, A
. & Jenkins, D
. (2006). Colonic health: ferm
entation and short chain fatty acids. Journal of C
linical Gastroenterology 40 (3): 235–243. Review
.
49 Guarner, F. &
Malagelada, J. (2003). G
ut flora in health and disease. The Lancet 361 (9356): 512–519. Review.
50 Jernberg, C. &
Löfmark, S. &
Edlund, C. &
Jansson, J. (2010). Long-term im
pacts of antibiotic exposure on the human intestinal m
icrobiota. M
icrobiology 156 (Pt 11): 3216–3223.
51 Beaugerie, L. &
Petit, J. (2004). Microbial-gut interactions in health and disease. A
ntibiotic-associated diarrhoea. Best Practice and Research Clinical
G
astroenterology 18 (2): 337–352. Review.
52 Thomas, C
. & Stevenson, M
. & W
illiamson, D
. & Riley, T. V. (2002). C
lostridium difficile-associated diarrhea: epidem
iological data from W
estern Australia
associated with a m
odified antibiotic policy. Clinical Infectious D
iseases 35 (12): 1457–1462.
53 Dethlefsen, L. &
Huse, S. &
Sogin, M. &
Relman, D
. (2008). The pervasive effects of an antibiotic on the human gut m
icrobiota, as revealed by deep 16S rRN
A sequencing. PLoS Biology 6 (11): e280.
Sold to Fred Block Block (#GJ57M
BGL)
150
54 World H
ealth Organization. (2014). W
HO
’s first global report on antibiotic resistance reveals serious, worldw
ide threat to public health. Geneva: W
HO
. [date of reference: 26.8.2014]
55 Forsythe, P. & Kunze, W
. (2013). Voices from w
ithin: gut microbes and the C
NS. C
ellular and Molecular Life Sciences 70 (1): 55–69. Review
.
56 Cryan, J. &
Dinan, T. (2012). M
ind-altering microorganism
s: the impact of the gut m
icrobiota on brain and behaviour. Nature Review
s Neuroscience
13 (10): 701–712. Review.
57 Cryan, J &
O’M
ahony, S. (2011). The microbiom
e-gut-brain axis: from bow
el to behavior. Neurogastroenterology and M
otility 23 (3): 187–192.
58 Grenham
, S. & C
larke, G. &
Cryan, J. &
Dinan, T. (2011). B
rain-gut-microbe com
munication in health and disease. Frontiers in Physiology 2: 94.
59 Foster, J. & M
cVey Neufeld, K. (2013). G
ut-brain axis: how the m
icrobiome influences anxiety and depression. Trends in N
eurosciences 36 (5): 305–312. Review
.
60 Mayer, E. (2011). G
ut feelings: the emerging biology of gut-brain com
munication. N
ature Revies Neuroscience 12 (8): 453–466. Review
.
61 Welgan, P. &
Meshkinpour, H
. & B
eeler, M. (1988). Effect of anger on colon m
otor and myoelectric activity in irritable bow
el syndrome.
Gastroenterology 94 (5 Pt 1): 1150–1156.
62 Travagli, R. & H
ermann, G
. & B
rowning, K. &
Rogers, R. (2006). Brainstem
circuits regulating gastric function. Annual Review
of Physiology 68: 279–305. Review
.
63 Mayer, E. (2000). The neurobiology of stress and gastrointestinal disease. G
ut 47: 861–869.
64 Hughes, D
. & Sperandio, V. (2008). Inter-kingdom
signalling: comm
unication between bacteria and their hosts. N
ature Reviews M
icrobiology 6: 111–120.
65 Fasano, A. (2012). Leaky gut and autoim
mune diseases. C
linical Reviews in A
llergy and Imm
unology 42 (1): 71–78.
66 Hollander, D
. (1999). Intestinal permeability, leaky gut, and intestinal disorders. C
urrent Gastroenterology Reports 1 (5): 410–416. Review
.
67 Hietbrink, F. (2009). System
ic inflamm
ation increases intestinal permeability during experim
ental human endotoxem
ia. Shock 32 (4): 374–378.
68 Frazier, T. & D
iBaise, J. &
McC
lain, C. (2011). G
ut microbiota, intestinal perm
eability, obesity-induced inflamm
ation, and liver injury. Journal of Parentereral and Enteral N
utrition 35 (5 Suppl): 14S–20S.
69 Neurath, M
. (2014). Cytokines in inflam
matory bow
el disease. Nature Review
s Imm
unology 14: 329–342.
70 Aloisi, F. (2001) Im
mune function of m
icroglia. Glia 36 (2): 165–179. Review
.
71 Foster, J. & M
cVey Neufeld, K. (2013). G
ut-brain axis: how the m
icrobiome influences anxiety and depression. Trends in N
euroscience 36 (5): 305–312. Review
.
Sold to Fred Block Block (#GJ57M
BGL)
151
72 Love, B. et al. (2013). A
ntibiotic exposure and risk of food allergy in children. 2013 Annual M
eeting of the Am
erican Academ
y of Allergy, A
sthma
and Imm
unology. [date of reference: 20.9.2014]
73 Vadas, P. & W
ai, Y. & B
urks, W. &
Perelman, B
. (2001). Detection of peanut allergens in breast m
ilk of lactating wom
en. The Journal of the Am
erican M
edical Association 285 (13): 1746–1748.
74 Kosecka, U. &
Berin, M
. & Perdue, M
. (1999). Pertussis adjuvant prolongs intestinal hypersensitivity. International Archives of A
llergy and Imm
unology 119 (3): 205–211.
75 Nakayam
a, T. & A
izawa, C
. & Kuno-Sakai, H
. (1999). A clinical analysis of gelatin allergy and determ
ination of its causal relationship to the previous adm
inistration of gelatin-containing acellular pertussis vaccine combined w
ith diphtheria and tetanus toxoids. The Journal of Allergy and C
linical Im
munology 103 (2 Pt 1): 321–325.
76 O’H
agan, D. (2000). Vaccine A
djuvants. Preparation Methods and Research Protocols. M
ethods in Molecular M
edicine. New
York: Hum
ana Press. [date of reference: 20.9.2014]
77 Jerschow, E. et al. (2012). D
ichlorophenol-containing pesticides and allergies: results from the U
S National H
ealth and Nutrition Exam
ination Survey 2005–2006. A
nnals of Allergy A
sthma and Im
munology 109 (6): 420–425.
78 Ortolani, C
. & Pastorello, E. (2006). Food allergies and food intolerances. Best Practice &
Research. Clinical G
astroenterology 20 (3): 467–83. Review.
79 David, T. (2000). A
dverse reactions and intolerance to foods. British Medical Bulletin 56 (1): 34–50.
80 Cardinale, F. et al. (2008). Intolerance to food additives: an update. M
inerva Pediatrica 60 (6): 1401–1409. Review.
81 Weidenhiller, M
. et al. (2012). Histam
ine intolerance syndrome (H
IS): plethora of physiological, pathophysiological and toxic mechanism
s and their differentiation. Zeitschrift für G
astroenterolie 50 (12): 1302–1309.
82 Maintz, L. &
Novak, N
. (2007). Histam
ine and histaminen intolerance. The A
merican Journal of C
linical Nutrition 8 (5): 1185–1196.
83 David, T. (2000). A
dverse reactions and intolerance to foods. British Medical Bulletin 56 (1): 34–50.
84 Hunt, P. &
Susiarjo, M. &
Rubio, C. &
Hassold, T. (2009). The bisphenol A
experience: a primer for the analysis of environm
ental effects on mam
malian
reproduction. Biology of Reproduction 81 (5): 807–813.
85 Singh, S. & Li, S. (2012). Epigenetic effects of environm
ental chemicals bisphenol a and phthalates. International Journal of M
olecular Sciences 13 (8): 10143–10153.
86 Sathyanarayana, S. et al. (2013). Unexpected results in a random
ized dietary trial to reduce phthalate and bisphenol A exposures.
Journal of Exposure Science and Environmental Epidem
iology 23 (4): 378–384.
87 Wagner, M
. & O
ehlmann, J. (2009). Endocrine disruptors in bottled m
ineral water: total estrogenic burden and m
igration from plastic bottles.
Environmental Science and Pollution Research 16 (3): 278–286.
Sold to Fred Block Block (#GJ57M
BGL)
152
88 Ben-Jonathan, N
. (1998). Xenoestrogens: prevalence, biologic effects, and mechanism
of action. In: Puga, A. &
Wallace, K. (eds.), M
olecular Biology of
the Toxic Response, 285–297. Boca Raton: C
RC Press. [date of reference: 21.9.2014]
89 Peumans, W
. & Van D
amm
e, E. (1995). Lectins as plant defense proteins. Plant Physiology 109 (2): 347–352. Review.
90 Rüdiger, H. (1998). Plant lectins – m
ore than just tools for glycoscientists: occurrence, structure, and possible functions of plant lectins. A
cta Anatom
ica (Basel) 161 (1–4): 130–152. Review.
91 Pusztai, A. et al. (1993). A
ntinutritive effects of wheat-germ
agglutinin and other N-acetylglucosam
ine-specific lectins. British Journal of Nutrition
70 (1): 313–321.
92 Dalla Pellegrina, C
. et al. (2009). Effects of wheat germ
agglutinin on human gastrointestinal epithelium
: insights from an experim
ental m
odel of imm
une/epithelial cell interaction. Toxicology and Applied Pharm
acology 237 (2): 146–153.
93 Vasconcelos, I. & O
liveira J. (2004). Antinutritional properties of plant lectins. Toxicon 44 (4): 385–403. Review
.
94 Freed, D. (1999). D
o dietary lectins cause disease? British Medical Journal 318 (7190): 1023–1024.
95 Jönsson, T. & O
lsson, S. & A
hrén, B. &
Bøg-H
ansen, T. & D
ole, A. &
Lindeberg, S. (2005). Agrarian diet and diseases of affluence – D
o evolutionary novel dietary lectins cause leptin resistance? BM
C Endocrine D
isorders 5: 10.
96 Forbes, R &, Parker, H
. & Erdm
an, J. Jr. (1984). Effects of dietary phytate, calcium and m
agnesium levels on zinc bioavailability to rats.
The Journal of Nutrition 114 (8): 1421–1425.
97 Speijers, G. (1993). C
yanogenic glycosides. WH
O Food A
dditives Series no. 30. <http://w
ww
.inchem.org/docum
ents/jecfa/jecmono/v30je18.htm
>
[date of reference: 3.9.2015]
98 Coe, F. &
Evan, A. &
Worcester, E. (2005). Kidney stone disease. The Journal of C
linical Investigation 115 (10): 2598–2608. Review.
99 Holm
es, R. & Kennedy, M
. (2000). Estimation of the oxalate content of foods and daily oxalate intake. Kidney International 57 (4): 1662–1667.
100 Weiven, C
. & Liebm
an, M. (2005). O
xalate content of legumes, nuts and grain-based flours. Journal of Food C
omposition and A
nalysis 18 (7): 723–729.
101 Francis, G. &
Kerem, Z. &
Makkar, H
. & B
ecker, K. (2002). The biological action of saponins in animal system
s: a review. British Journal of N
utrition 88 (6): 587–605. Review
.
102 Shi, J. et al. (2004). Saponins from edible legum
es: chemistry, processing, and health benefits. Journal of M
edicinal Food 7 (1): 67–78. Review.
103 Johnson, I. & G
ee, J. & Price, K. &
Curl, C
. & Fenw
ick, G. (1986). Influence of saponins on gut perm
eability and active nutrient transport in vitro. The Journal of N
utrition 116 (11): 2270–2277.
104 Keukens, E. et al. (1996). Glycoalkaloids selectively perm
eabilize cholesterol containing biomem
branes. Biochimica et Biophysica A
cta 1279 (2): 243–250.
105 Patel, B. et al. (2002). Potato glycoalkaloids adversely affect intestinal perm
eability and aggravate inflamm
atory bowel disease.
Inflamm
atory Bowel D
iseases 8 (5): 340–346.
Sold to Fred Block Block (#GJ57M
BGL)
153
106 Friedman, M
. (2002). Tomato glycoalkaloids: role in the plant and in the diet. Journal of A
gricultural and Food Chem
istry 50 (21): 5751–5780. Review.
107 Fasano, A. (2011). Zonulin and its regulation of intestinal barrier function: the biological door to inflam
mation, autoim
munity, and cancer.
Physiological Reviews 91 (1): 151–175.
108 Drago, S. et al. (2006). G
liadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal m
ucosa and intestinal cell lines. Scandinavian Journal of G
astroenterology 41 (4): 408–419.
109 Doerge, D
. & Sheehan, D
. (2002). Goitrogenic and estrogenic activity of soy isoflavones. Environm
ental Health Perspectives 110 Suppl 3: 349–353. Review
.
110 Greer, M
. (1957). Goitrogenic substances in food. The A
merican Journal of C
linical Nutrition 5 (4): 440–444.
111 Sarne, D. (2010). Effects of the Environm
ent, Chem
icals and Drugs on Thyroid Function. Thyroid D
isease Manager, 1–53. [date of reference: 15.7.2014]
112 Thompson, L. &
Boucher, B
. & Liu, Z. &
Cotterchio, M
. & Kreiger, N
. (2006). Phytoestrogen content of foods consumed in C
anada, including isoflavones, lignans, and coum
estan. Nutrition and C
ancer 54 (2): 184–201.
113 Turner, J. & A
gatonovic-Kustrin, S. & G
lass, B. (2007). M
olecular aspects of phytoestrogen selective binding at estrogen receptors. Journal of Pharm
aceutical Sciences 96 (8): 1879–1885. Review.
114 Patisaul, H. &
Jefferson, W. (2010). The pros and cons of phytoestrogens. Frontiers in N
euroendocrinology 31 (4): 400–419.
115 Ham
ilton-Reeves, J. et al. (2010). Clinical studies show
no effects of soy protein or isoflavones on reproductive hormones in m
en: results of a m
eta-analysis. Fertility and Sterility 94 (3): 997–1007.
116 Tan-Wilson, A
. et al. (1987). Soybean Bow
man-B
irk trypsin insoinhibitors: classification and report of a glycine-rich trypsin inhibitor class. Journal of A
gricultural and Food Chem
istry 35 (6): 974–981.
117 Preuss, H. (2009). B
ean amylase inhibitor and other carbohydrate absorption blockers: effects on diabesity and general health.
Journal of Am
erican College N
utrition 28 (3): 266–276.
118 Lalonde, M. (2011). A
n Organic C
hemist’s Perspective on Paleo. A
ncestral Health Sym
posium.
119 Ibrahim, S. &
Habiba, R. &
Shatta, A. &
Embaby, H
. (2002). Effect of soaking, germination,cooking and ferm
entation on antinutritional factors in cow
peas. Die N
ahrung 46 (2): 92–95.
120 Hotz, C
. & G
ibson, R. (2007). Traditional food-processing and preparation practices to enhance the bioavailability of micronutrients in plant-based
diets. The Journal of Nutrition 37 (4): 1097–1100. Review
.
121 Akande, E. &
Fabiyi, E. (2010). Effect of processing methods on som
e antinutritional factors in legume seeds for poultry feeding.
International Journal of Poultry Science 9 (10): 996–1001.
122 Hardy, H
. & H
arris, J. & Lyon, E. &
Beal, J. &
Foey ,A. (2013). Probiotics, Prebiotics and Im
munom
odulation of Gut M
ucosal Defences: H
omeostasis and
Imm
unopathology. Nutrients 5 (6):1869–1912.
Sold to Fred Block Block (#GJ57M
BGL)
154
123 Playford, R. et al. (1999). Bovine colostrum
is a health food supplement w
hich prevents NSA
ID induced gut dam
age. Gut 44 (5): 653–658.
124 Wang, B
. et a. (2015). Glutam
ine and intestinal barrier function. Am
ino Acids 47 (10): 2143–2154.
125 Uehleke, B
. & O
rtiz, M. &
Stange, R. (2012). Silicea gastrointestinal gel improves gastrointestinal disorders: a non-controlled, pilot clinical study.
Gastroenterology Research and Practice 2012: 750750.
126 Wong, J. &
de Souza, R. & Kendall, C
. & Em
am, A
. & Jenkins, D
. (2006). Colonic health: ferm
entation and short chain fatty acids. Journal of C
linical Gastroenterology 40 (3): 235–243. Review
.
127 Gibson, P &
Shepherd, S. (2010). Evidence-based dietary managem
ent of functional gastrointestinal symptom
s: The FOD
MA
P approach. Journal of G
astroenterology and Hepatology 25 (2): 252–258.
128 Ong, D
. et al. (2010). Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of sym
ptoms in irritable bow
el syndrom
e. Journal of Gastroenterology and H
epatology 25 (8): 1366–1373.
129 David, L. et al. (2014). D
iet rapidly and reproducibly alters the human gut m
icrobiome. N
ature 505 (7484): 559–563.
130 Xiao, S. et al. (2014). A gut m
icrobiota-targeted dietary intervention for amelioration of chronic inflam
mation underlying m
etabolic syndrome.
FEMS M
icrobiology Ecology 87 (2): 357–367.
131 Fasano, A. (2012). Leaky gut and autoim
mune diseases. C
linical Reviews in A
llergy and Imm
unology 42 (1): 71–78. Review.
132 Jenkins, D. &
Kendall, C. &
Vuksan, V. (1999). Inulin, oligofructose and intestinal function. The Journal of Nutrition 129 (7 Suppl): 1431S–1433S. Review
.
133 Kruse, H. &
Kleessen, B. &
Blaut, M
. (1999). Effects of inulin on faecal bifidobacteria in human subjects. British Journal of N
utrition 82 (5): 37582.
134 Savard, P. et al. (2011). Impact of B
ifidobacterium anim
alis subsp. lactis BB
-12 and, Lactobacillus acidophilus LA-5-containing yoghurt, on fecal bacterial
counts of healthy adults. International Journal of Food Microbiology 149 (1): 50–67.
135 Saxelin, M. (2010). Persistence of probiotic strains in the gastrointestinal tract w
hen administered as capsules, yoghurt, or cheese.
International Journal of Food Microbiology 144 (2): 293–300.
136 Haenen, D
. (2013). A diet high in resistant starch m
odulates microbiota com
position, SCFA
concentrations, and gene expression in pig intestine. The Journal of N
utrition 143 (3): 274–283.
137 Martínez, I. &
Kim, J. &
Duffy, P. &
Schlegel, V. & W
alter, J. (2010). Resistant starches types 2 and 4 have differential effects on the composition of the
fecal microbiota in hum
an subjects. PLoS One 5 (11): e15046.
138 Rastmanesh, R. (2011). H
igh polyphenol, low probiotic diet for w
eight loss because of intestinal microbiota interaction. C
hemico-Biological Interactions
189 (1–2): 1–8. Review.
139 Moore, M
. & G
oita, M. &
Finley, J. (2014). Impact of the M
icrobiome on C
ocoa Polyphenolic Com
pounds. National M
eeting & Exposition of the
A
merican C
hemical Society. D
epartment of N
utrition and Food Science, Louisiana State University.
Sold to Fred Block Block (#GJ57M
BGL)
155
140 Ukhanova, M
. et al. (2014). Effects of almond and pistachio consum
ption on gut microbiota com
position in a randomised cross-over hum
an feeding study. British Journal of N
utrition 111 (12): 2146–2152.
141 Pérez-Cobas, A
. et al. (2013). Gut m
icrobiota disturbance during antibiotic therapy: a multi-om
ic approach. Gut 62 (11): 1591–1601.
142 Shehata, A. &
Schrödl, W. &
Aldin, A
. & H
afez, H. &
Krüger, M. (2013). The effect of glyphosate on potential pathogens and beneficial m
embers of
poultry microbiota in vitro. C
urrent Microbiology 66 (4): 350–358.
143 Samsel, A
. & Seneff, S. (2013). G
lyphosate, pathways to m
odern diseases II: Celiac sprue and gluten intolerance. Interdisciplinary Toxicology
6 (4): 159–184. Review.
144 Massarrat, S. (2008). Sm
oking and gut. Archives of Iranian M
edicine 11 (3): 293–305.
145 Purohit, V. et al. (2008). Alcohol, intestinal bacterial grow
th, intestinal permeability to endotoxin, and m
edical consequences: summ
ary of a symposium
. A
lcohol (Fayettevlle, N.Y.) 42 (5): 349–361.
146 La Fleur, S. & W
ick, E. & Idum
alla, P. & G
rady, E. & B
hargava, A. (2005). Role of peripheral corticotropin-releasing factor and urocortin II in intestinal
inflamm
ation and motility in term
inal ileum. Proceedings of the N
ational Academ
y of Sciences 102: 7647–7652.
147 Maier, S. &
Watkins, L. (1998). C
ytokines for psychologists: implications of bidirectional im
mune-to-brain com
munication for understanding behavior,
mood, and cognition. Psychological Review
s 105 (1): 83–107. Review.
148 Forsythe, P. & Sudo, N
. & D
inan, T. & Taylor, V. &
Bienenstock, J. (2010). Mood and gut feelings. Brain Behavior and Im
munity 24 (1): 9–16. Review
.
149 Dim
idi, E. & C
hristodoulides, S. & Fragkos, K. &
Scott, S. & W
helan, K. (2014). The effect of probiotics on functional constipation in adults: a systematic
review and m
eta-analysis of randomized controlled trials. The A
merican Journal of C
linical Nutrition 100 (4): 1075–1084.
150 Salari, P. & N
ikfar, S. & A
bdollahi, M. (2012). A
meta-analysis and system
atic review on the effect of probiotics in acute diarrhea.
Inflamm
ation and Allergy D
rug Targets 11 (1): 3–14. Review.
151 McFarland, L. (2007). M
eta-analysis of probiotics for the prevention of traveler’s diarrhea. Travel Medicine and Infectious D
isease 5 (2): 97–105.
152 Nikfar, S. &
Rahimi, R. &
Rahimi, F. &
Derakhshani, S. &
Abdollahi, M
. (2008). Efficacy of probiotics in irritable bowel syndrom
e: a meta-analysis of
randomized, controlled trials. The D
iseases of Colon and Rectum
51 (12): 1775–1780.
153 Shen, J. & Zuo, Z. &
Mao, A
. (2014). Effect of probiotics on inducing remission and m
aintaining therapy in ulcerative colitis, Crohn’s disease, and
pouchitis: meta-analysis of random
ized controlled trials. Inflamm
atory Bowel D
iseases 20 (1): 21–35.
154 Sang, L. et al. (2010). Remission induction and m
aintenance effect of probiotics on ulcerative colitis: a meta-analysis.
World Journal of G
astroenterology 16 (15): 1908–1915.
155 Ma ,Y. et al. (2013). Effects of probiotics on nonalcoholic fatty liver disease: a m
eta-analysis. World Journal of G
astroenterology 19 (40): 6911–6918. Review.
156 Kang, E. & Kim
, S. & H
wang, H
. & Ji, Y. (2013). The effect of probiotics on prevention of com
mon cold: a m
eta-analysis of randomized controlled trial
studies. Korean Journal of Family M
edicine 34 (1): 2–10.
Sold to Fred Block Block (#GJ57M
BGL)
156
157 Hem
pel, S. et al. (2012). Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a system
atic review and m
eta-analysis. The Journal of the A
merican M
edical Association 307 (18): 1959–1969. Review
.
158 Plengvidhya, V. & B
reidt, F. Jr. & Lu, Z. &
Fleming, H
. (2007). DN
A fingerprinting of lactic acid bacteria in sauerkraut ferm
entations. A
pplied and Environmental M
icrobiology 73 (23): 7697–7702.
159 Scholz-Ahrens, K. &
Schrezenmeir, J. (2007). Inulin and oligofructose and m
ineral metabolism
: the evidence from anim
al trials. The Journal of Nutrition
137 (11 Suppl): 2513S–2523S. Review.
160 Lomax, A
. & C
alder, P. (2009). Prebiotics, imm
une function, infection and inflamm
ation: a review of the evidence. British Journal of N
utrition 101 (5): 633–658. Review
.
161 Geier, M
. & B
utler, R. & H
owarth, G
. (2006). Probiotics, prebiotics and synbiotics: a role in chemoprevention for colorectal cancer?
Cancer Biology and Therapy 5 (10): 1265–1269. Review
.
162 Grabitske, H
. & Slavin, J. (2009). G
astrointestinal effects of low-digestible carbohydrates. C
ritical Reviews in Food Science and N
utrition (4): 327–360. Review
.
163 Harazaki, T. &
Inoue, S. & Im
ai, C. &
Mochizuki, K. &
Goda, T. (2014). Resistant starch im
proves insulin resistance and reduces adipose tissue weight and
CD
11c expression in rat OLETF adipose tissue. N
utrition 30 (5): 590–595.
164 Higgins, J. (2011). Resistant starch and exercise independently attenuate w
eight regain on a high fat diet in a rat model of obesity.
Nutrition and M
etabolism 8: 49.
165 Belobrajdic, D
. & King, R. &
Christophersen, C
. & B
ird, A. (2012). D
ietary resistant starch dose-dependently reduces adiposity in obesity-prone and obesity-resistant m
ale rats. Nutrition and M
etabolism 9 (1): 93.
166 Robertson, M. (2012). Insulin-sensitizing effects on m
uscle and adipose tissue after dietary fiber intake in men and w
omen w
ith metabolic syndrom
e. The Journal of C
linical Endocrinology and Metabolism
97 (9): 3326–3332.
167 Higgins, J. (2014). Resistant starch and energy balance: im
pact on weight loss and m
aintenance. Critical Review
s in Food Science and Nutrition
54 (9): 1158–1566. Review.
168 Nichenam
etla, S. et al. (2014). Resistant starch type 4-enriched diet lowered blood cholesterols and im
proved body composition in a double blind
controlled cross-over intervention. Molecular N
utrition and Food Research 58 (6): 1365–1369.
169 Kwak, J. et al. (2012). D
ietary treatment w
ith rice containing resistant starch improves m
arkers of endothelialfunction with reduction of postprandial blood
glucose and oxidative stress in patients with prediabetes or new
ly diagnosed type 2 diabetes. Atherosclerosis 224 (2): 457–464.
170 Moshfegh, A
. & Friday, J. &
Goldm
an, J. & A
huja, J. (1999). Presence of inulin and oligofructose in the diets of Am
ericans. The Journal of Nutrition
129 (7 Suppl): 1407S–1411S.
171 Vermeulen, M
. & Klöpping-Ketelaars, I. &
van den Berg, R. &
Vaes, W. (2008). B
ioavailability and kinetics of sulforaphane in humans after consum
ption of cooked versus raw
broccoli. Journal of Agricultural and Food C
hemistry 56 (22): 10505–10509.
Sold to Fred Block Block (#GJ57M
BGL)
157
172 Dew
anto, V. & W
u, X. & A
dom, K. K. &
Liu, R. H. (2002). Therm
al processing enhances the nutritional value of tomatoes by increasing total antioxidant
activity. Journal of Agricultural and Food C
hemistry 50 (10): 3010–3014.
173 Seiquer, I. et al. (2006). Diets rich in M
aillard reaction products affect protein digestibility in adolescent males aged 11–14 y. The A
merican Journal of
Clinical N
utrition 83 (5): 1082–1088.
174 Stadler, R. & B
lank, I. & Varga, N
. & Robert, F. &
Hau, J. &
Guy, P. &
Robert, M. &
Riediker, S. (2002). Acrylam
ide from M
aillard reaction products. N
ature 419 (6906): 449–450.
175 Yamagishi, S. et al. (2012). Role of advanced glycation end products (A
GEs) and oxidative stress in vascular com
plications in diabetes. Biochim
ica et Biophysica Acta 1820 (5): 663–671.
176 Birlouez-A
ragon, I. et al. (2010). A diet based on high-heat-treated foods prom
otes risk factors for diabetes mellitus and cardiovascular diseases.
The Am
erican Journal of Clinical N
utrition 91 (5): 1220–1226.
177 Uribarri, J. et al. (2010). A
dvanced glycation end products in foods and a practical guide to their reduction in the diet. Journal of the A
merican D
ietic Association 110 (6): 911–916.e12.
178 Bassioni, G
. & M
ohamm
ed, F. S. & A
l Zubaidy, E. & Kobrsi, I. (2012). Risk A
ssessment of U
sing Alum
inum Foil in Food Preparation.
International Journal of Electrochemical Science 7: 4498–4509.
179 Viegas, O. &
Am
aro, L. F. & Ferreira, I. M
. & Pinho, O
. (2012). Inhibitory effect of antioxidant-rich marinades on the form
ation of heterocyclic aromatic
amines in pan-fried beef. Journal of A
gricultural Food and Chem
istry 60 (24): 6235–6240.
180 Melo, A
. & Viegas, O
. & Petisca, C
. & Pinho, O
. & Ferreira, I. M
. (2008). Effect of beer/red wine m
arinades on the formation of heterocyclic arom
atic am
ines in pan-fried beef. Journal of Agricultural and Food C
hemistry 56 (22): 10625–10632.
181 Platt, K. L. & Edenharder, R. &
Aderhold, S. &
Muckel, E. &
Glatt, H
. (2010). Fruits and vegetables protect against the genotoxicity of heterocyclic arom
atic amines activated by hum
an xenobiotic-metabolizing enzym
es expressed in imm
ortal mam
malian cells. M
utation Research 703 (2): 90–98.
182 Balogh, Z. &
Gray, J. I. &
Gom
aa, E. A. &
Booren, A
. M. (2000). Form
ation and inhibition of heterocyclic aromatic am
ines in fried ground beef patties. Food and C
hemical Toxicology 38 (5): 395–401.
183 Vinson, J. & H
oward, T. B
. (1996). Inhibition of protein glycation and advanced glycation end products by ascorbic acid and other vitamins and
nutrients. The Journal of Nutritional Biochem
istry 12 (7): 659–663.
184 Tang, Y. & C
hen, A. (2014). C
urcumin elim
inates the effect of advanced glycation end-products (AG
Es) on the divergent regulation of gene expression of receptors of A
GEs by interrupting leptin signaling. Laboratory Investigation 94 (5): 503–516.
185Persson, E. & G
raziani, G. &
Ferracane, R. & Fogliano, V. &
Skog, K. (2003). Influence of antioxidants in virgin olive oil on the formation of heterocyclic
amines in fried beefburgers. Food and C
hemical Toxicology 41 (11): 1587–1597.
186 Uribarri, J. et al. (2010). A
dvanced glycation end products in foods and a practical guide to their reduction in the diet. Journal of the Am
erican Dietetic
Association 110 (6): 911–16.e12.
Sold to Fred Block Block (#GJ57M
BGL)
158
187 Skog, K. (1993). Cooking procedures and food m
utagens: a literature review. Food and C
hemical Toxicology 31 (9): 655–675. Review
.
188 Skog, K. & Viklund, G
. & O
lsson, K. & Sjöholm
, I. (2008). Acrylam
ide in home-prepared roasted potatoes. M
olecular Nutrition &
Food Research 52 (3): 307–312.
189 Bråthen, E. &
Kita, A. &
Knutsen, S. H. &
Wicklund, T. (2005). A
ddition of glycine reduces the content of acrylamide in cereal and potato products.
Journal of Agricultural and Food C
hemistry 53 (8): 3259–3264.
190 Chiavaro, E. &
Mazzeo, T. &
Visconti, A. &
Manzi, C
. & Fogliano, V. &
Pellegrini, N. (2012). N
utritional quality of sous vide cooked carrots and brussels sprouts. Journal of A
gricultural and Food Chem
istry 60 (23): 6019–6025.
191 Shishu & Kaur, I. (2003). Inhibition of m
utagenicity of food-derived heterocyclic amines by sulforaphane, a constituent of broccoli.
Indian Journal of Experimental Biology 41 (3): 216–219.
192 Ghaw
i, S. & M
ethven, L. & N
iranjan, K. (2013). The potential to intensify sulforaphane formation in cooked broccoli (B
rassica oleracea var. italica) using m
ustard seeds (Sinapis alba). Food Chem
istry 138 (2–3): 1734–1741.
193 Narciso-G
aytán, C. et al. (2011). Lipid oxidation stability of om
ega-3- and conjugated linoleic acid-enriched sous vide chicken meat.
Poultry Science 90 (2): 473–480.
194 Valtion ravitsemusneuvottelukunta. Ravitsem
ussuositukset kuvaavat väestöjen ja ihmisryhm
ien energian ja ravintoaineiden tarvetta tai suositeltavaa saantia. H
elsinki: Maa- ja m
etsätalousministeriö. [date of reference: 9.10.2014]
195 Stover, P. (2006). Influence of human genetic variation on nutritional requirem
ents. The Am
erican Journal Clinical N
utrition 83 (2): 436S–442S. Review.
196 Zeisel, S. (2011). Nutritional genom
ics: defining the dietary requirement and effects of choline. The Journal of N
utrition 141 (3): 531–534. Review.
197 Am
es, B. &
Atam
na, H. &
Killilea, D. (2005). M
ineral and vitamin deficiencies can accelerate the m
itochondrial decay of aging. M
olecular Aspects of M
edicine 26 (4–5): 363–378. Review.
198 Am
es, B. (2006). Low
micronutrient intake m
ay accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage.
Proceedings of the National A
cademy of Sciences of the U
nited States of Am
erica 103 (47): 17589–17594. Review.
199 Hargrove, J. (2006). H
istory of the calorie in nutrition. The Journal of Nutrition 136 (12): 2957–2961.
200 Peters, L. (1918). Diet and health w
ith key to the calories. Chicago: Reilly and Lee.
201 Hopkins, F. (1912). Feeding experim
ents illustrating the importance of accessory factors in norm
al dietaries. The Journal of Physiology 44: 425–460.
202 Semba, R. (2012). The historical evolution of thought regarding m
ultiple micronutrient nutrition. The Journal of N
utrition 142 (1): 143S–156S. Review.
203 The Norw
egian University of Science and Technology (N
TNU
). (2011). Feed your genes: How
our genes respond to the foods we eat.
ScienceD
aily. <http://w
ww
.sciencedaily.com/releases/2011/09/110919073845.htm
>
Sold to Fred Block Block (#GJ57M
BGL)
159
204 Eichner, J. & D
unn, S. & Perveen, G
. & Thom
pson, D. &
Stewart, K. &
Stroehla, B. (2002). Apolipoprotein E polym
orphism and cardiovascular
disease: a HuG
E review. A
merican journal of epidem
iology 155 (6): 487–495. Review.
205 Filippini, N. et al. (2009). D
istinct patterns of brain activity in young carriers of the APO
E-epsilon4 allele. Proceedings of the National A
cademy of Sciences
of the U
nited States of Am
erica 106 (17): 7209–7214.
206 Stumvoll, M
. & H
äring, H. (2002). The peroxisom
e proliferator-activated receptor-gamm
a2 Pro12Ala polym
orphism. D
iabetes 51 (8): 2341–2347. Review.
207 Heikkinen, S. et al. (2009). The Pro12A
la PPARgam
ma2 variant determ
ines metabolism
at the gene-environment interface. C
ell Metabolism
9 (1): 88–98.
208 Scott, L. et al. (2006). Association of transcription factor 7-like 2 (TC
F7L2) variants with type 2 diabetes in a Finnish sam
ple. Diabetes 55 (9): 2649–2653.
209 Kurokawa, N
. et al. (2008). Then AD
RB3 Trp64Arg variant and BM
I: a meta-analysis of 44 833 individuals. International Journal of O
besity 32 (8): 1240–1249.
210 Arner, P. &
Hoffstedt, J. (1999). A
drenoceptor genes in human obesity. Journal of International M
edicine 245 (6): 667–672. Review.
211 The Wellcom
e Trust Case C
ontrol Consortium
. (2007). Genom
e-wide association study of 14,000 cases of seven com
mon diseases and 3,000 shared
controls. Nature 447 (7145): 661–678.
212 Frayling, T. et al. (2007). A com
mon variant in the FTO
gene is associated with body m
ass index and predisposes to childhood and adult obesity. Science 316 (5826): 889–894.
213 Corella, D
. et al. (2011). Association of the LC
T-13910C>
T polymorphism
with obesity and its m
odulation by dairy products in a Mediterranean
population. O
besity (Silver Spring) 19 (8): 1707–1714.
214 Bersaglieri, T. et al. (2004). G
enetic signatures of strong recent positive selection at the lactase gene. Am
erican Journal of Hum
an Genetics
74 (6): 1111–1120.
215 Vives-Pi, M. et al. (2013). B
iomarkers for diagnosis and m
onitoring of celiac disease. Journal of Clinical G
astroenterology 47 (4): 308–313. Review.
216 van den Wildenberg, E. et al. (2007). A
functional polymorphism
of the mu-opioid receptor gene (O
PRM1) influences cue-induced craving for alcohol in
m
ale heavy drinkers. Alcoholism
: Clinical and Experim
ental Research 31 (1): 1–10.
217 Sookoian, S. & Pirola, C
. J. (2011). Meta-analysis of the influence of I148M
variant of patatin-like phospholipase domain containing 3 gene (PN
PLA3)
on the susceptibility and histological severity of nonalcoholic fatty liver disease. Hepatology 53 (6): 1883–1894. Review
.
218 Cornelis, M
. & El-Sohem
y, A. &
Kabagambe, E. &
Cam
pos, H. (2006). C
offee, CYP1A
2 genotype, and risk of myocardial infarction.
The Journal of the Am
erican Medical A
ssociation 295 (10): 1135–1141.
219 Palatini, P. et al. (2009). CYP1A
2 genotype modifies the association betw
een coffee intake and the risk of hypertension. Journal of Hypertension
27 (8): 1594–1601.
220 Alfthan, G
. & Laurinen, M
. & Valsta, L. &
Pastinen, T. & A
ro, A. (2003). Folate intake, plasm
a folate and homocysteine status in a random
Finnish population. European Journal of C
linical Nutrition 57 (1): 81–88.
Sold to Fred Block Block (#GJ57M
BGL)
160
221 Neville, M
. & Johnstone, E. &
Walton, R. (2004). Identification and characterization of A
NKK1: a novel kinase gene closely linked to D
RD2 on
chromosom
e band 11q23.1. Hum
an Mutatation 23 (6): 540–545.
222 Blum
, K. & O
scar-Berm
an, M. &
Barh, D
. & G
iordano, J. & G
old, M. (2013). D
opamine G
enetics and Function in Food and Substance Abuse.
Journal of Genetic Syndrom
e and Gene Therapy 4 (121). pii: 1000121.
223 Ariza, M
. et al. (2012). Dopam
ine genes (DRD
2/AN
KK1-TaqA1 and D
RD4-7R) and executive function: their interaction w
ith obesity. PLoS One 7 (7): e41482.
224 Kilcoyne, B. et al. (2014). A
lcohol consumption m
ediates the relationship between A
DH
1B and D
SM-IV alcohol use disorder and criteria.
Journal of Studies on Alcohol and D
rugs 75 (4): 635–642.
225 Quertem
ont, E. (2004). Genetic polym
orphism in ethanol m
etabolism: acetaldehyde contribution to alcohol abuse and alcoholism
. M
olecular Psychiatry 9 (6): 570–581. Review.
226 Calton, J. (2010). Prevalence of m
icronutrient deficiency in popular diet plans. Journal of the International Society of Sports Nutrition 7: 24.
227 Baranski, M
. et al. (2014). Higher antioxidant and low
er cadmium
concentrations and lower incidence of pesticide residues in organically grow
n crops: a system
atic literature review and m
eta-analyses. The British Journal of Nutrition 26: 1–18.
228 Sarkkinen, E. et al. (2011). Feasibility and antihypertensive effect of replacing regular salt with m
ineral salt – rich in magnesium
and potassium – in
subjects with m
ildly elevated blood pressure. Nutrition Journal 10: 88, 1–9.
229 O’D
onnell, M. &
Mente, A
. & Rangarajan, S. et al. (2014). U
rinary sodium and potassium
excretion, mortality, and cardiovascular events.
The New
England Journal of Medicine 371 (7): 612–623.
230 Malik, V. et al. (2010). Sugar-sw
eetened beverages and risk of metabolic syndrom
e and type 2 diabetes: a meta-analysis. D
iabetes Care 33 (11): 2477–2483.
231 Malik, V. et al. (2010). Sugar-sw
eetened beverages, obesity, type 2 diabetes mellitus, and cardiovascular disease risk. C
irculation 121 (11): 1356–1364. Review.
232 Brow
n, C. &
Dulloo, A
. & M
ontani, J. (2008). Sugary drinks in the pathogenesis of obesity and cardiovascular diseases. International Journal of Obesity
32 Suppl 6: S28–34. Review.
233 Welsh, J. &
Sharma, A
. & C
unningham, S. &
Vos, M. (2011). C
onsumption of added sugars and indicators of cardiovascular disease risk am
ong US
adolescents. Circulation 123 (3): 249–257.
234 de la Monte, S. &
Wands, J. (2008). A
lzheimer’s disease is type 3 diabetes-evidence review
ed. Journal of Diabetes Science and Technology
2 (6): 1101–1113.
235 Moreira, P. (2013). H
igh-sugar diets, type 2 diabetes and Alzheim
er’s disease. Current O
pinion in Clinical N
utrition and Metabolic C
are 16 (4): 440–445. Review
.
236 Chiu, S. et al. (2014). Effect of fructose on m
arkers of non-alcoholic fatty liver disease (NA
FLD): a system
atic review and m
eta-analysis of controlled feeding trials. European Journal of C
linical Nutrition 68 (4): 416–423.
Sold to Fred Block Block (#GJ57M
BGL)
161
237 Avena, N
. & Rada, P. &
Hoebel, B
. (2008). Evidence for sugar addiction: behavioral and neurochemical effects of interm
ittent, excessive sugar intake. N
euroscience and Behavioral Reviews 32 (1): 20–39. Review
.
238 Miceli Sopo, S. &
Greco, M
. & M
onaco, S. & Varrasi, G
. & D
i Lorenzo, G. &
Simeone, G
. (2014). Effect of multiple honey doses on non-specific acute
cough in children. An open random
ised study and literature review. A
llergologia et Imm
unopathologia 43 (5): 449–455.
239 Wagner, J. &
Pine, H. (2013). C
hronic cough in children. Pediatric Clinics of N
orth Am
erica 60 (4): 951–967.
240 Mishra, S. &
Palanivelu, K. (2008). The effect of curcumin (turm
eric) on Alzheim
er’s disease: An overview
. Annals of Indian A
cademy of N
eurology 11 (1): 13–19.
241 Chandran, B
. & G
oel, A. (2012). A
randomized, pilot study to assess the efficacy and safety of curcum
in in patients with active rheum
atoid arthritis. Phytotherapy Research 26 (11): 1719–1725.
242 Park, C. et al. (2007). C
urcumin induces apoptosis and inhibits prostaglandin E(2) production in synovial fibroblasts of patients w
ith rheumatoid arthritis.
International Journal of Molecular M
edicine 20 (3): 365–372.
243 Hanai, H
. & Sugim
oto, K. (2009). Curcum
in has bright prospects for the treatment of inflam
matory bow
el disease. Current Pharm
acological Design
15 (18): 2087–2094. Review.
244 Moghadam
tousi, S. et al. (2014). A review
on antibacterial, antiviral, and antifungal activity of curcumin. Biom
ed Research International 2014: 186864.
245 Bar-Sela, G
. & Epelbaum
, R. & Schaffer, M
. (2010). Curcum
in as an anti-cancer agent: review of the gap betw
een basic and clinical applications. C
urrent Medical C
hemistry 17 (3): 190–197. Review
.
246 Wilken, R. &
Veena, M. &
Wang, M
. & Srivatsan, E. (2011). C
urcumin: A
review of anti-cancer properties and therapeutic activity in head and neck
squamous cell carcinom
a. Molecular C
ancer 10: 12. Review.
247 Larsson, S. & W
olk, A. (2006). M
eat consumption and risk of colorectal cancer: a m
eta-analysis of prospective studies. International Journal of Cancer
119 (11): 2657–2664.
248 Micha, R. &
Mozaffarian, D
. (2012). Unprocessed Red and Processed M
eats and Risk of Coronary A
rtery Disease and Type 2 D
iabetes – An U
pdated Review
of the Evidence. Current A
therosclerosis Reports 14 (6): 515–552.
249 Kaluza, J. & W
olk, A. &
Larsson, S. (2012). Red meat consum
ption and risk of stroke: a meta-analysis of prospective studies. Stroke 43 (10): 2556–2560.
250 Huang, W
. et al. (2013). Red and processed meat intake and risk of esophageal adenocarcinom
a: a meta-analysis of observational studies.
Cancer C
auses and Control 24 (1): 193–201.
251 Zhu, H. et al. (2013). Red and processed m
eat intake is associated with higher gastric cancer risk: a m
eta-analysis of epidemiological observational
studies. PLoS One 8 (8): e70955.
252 O’Sullivan, T. et al. (2013). Food sources of saturated fat and the association w
ith mortality: a m
eta-analysis. Am
erican Journal of Public Health
103: e31–42.
Sold to Fred Block Block (#GJ57M
BGL)
162
253 McD
aniel, J. & A
skew, W
. & B
ennett, D. (2013). B
ison meat has a low
er atherogenic risk than beef in healthy men. N
utrition Research 33 (4): 293–302.
254 Leheska, J. et al. (2008). Effects of conventional and grass-feeding systems on the nutrient com
position of beef. Journal of Anim
al Sciences 86 (12): 3575–3585.
255 Sun, L. & Sadighi A
kha A. &
Miller, R. &
Harper, J. (2009). Life-span extension in m
ice by preweaning food restriction and by m
ethionine restriction in m
iddle age. The Journals of Gerontology Series A
: Biological Sciences and Medical Sciences 64 (7): 711–722.
256 López-Torres, M. &
Barja, G
. (2008). Lowered m
ethionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein
and dietary restriction possible implications for hum
ans. Biochimica et Biophysica A
cta 1780 (11): 1337–1347. Review.
257 Sanchez-Roman, I. &
Barja, G
. (2013). Regulation of longevity and oxidative stress by nutritional interventions: role of methionine restriction.
Experimental G
erontology 48 (10): 1030–1042. Review.
258 Brind, J. et al. (2011). D
ietary glycine supplementation m
imics lifespan extension by dietary restriction in Fisher 344 rats.
The FASEB Journal Supplem
ent 528.2.
259 Díaz-Flores, M
. et al. (2013). Oral supplem
entation with glycine reduces oxidative stress in patients w
ith metabolic syndrom
e, improving their systolic
blood pressure. Canadian Journal of Physiology and Pharm
acology 91 (10): 855–860.
260 White, D
. & C
ollinson, A. (2013). Red m
eat, dietary heme iron, and risk of type 2 diabetes: the involvem
ent of advanced lipoxidation endproducts. A
dvances in Nutrition 4 (4): 403–411. Review
.
261 United N
ations Environment Program
me. (2013). M
inamata C
onvention on Mercury (19.1.2013, G
eneva, Switzerland) <
ww
w.m
ercuryconvention.org>
[date of reference: 12.10.2014]
262 Sidhu, K. (2003). Health benefits and potential risks related to consum
ption of fish or fish oil. Regulatory Toxicology and Pharmacology 38 (3): 336–344.
263 Leung Yinko, S. & Stark, K. &
Thanassoulis, G. &
Pilote, L. (2014). Fish consumption and acute coronary syndrom
e: a meta-analysis.
The Am
erican Journal of Medicine 127 (9): 848–857.e2.
264 Song, J. & Su, H
&, W
ang, B. &
Zhou, Y. & G
uo, L. (2014). Fish consumption and lung cancer risk: system
atic review and m
eta-analysis. N
utrition and Cancer (4): 539–549.
265 Zhang, M. &
Picard-Deland, E. &
Marette, A
. (2013). Fish and marine om
ega-3 polyunsatured Fatty Acid consum
ption and incidence of type 2 diabetes: a system
atic review and m
eta-analysis. International Journal of Endocrinology 2013: 501015. Review.
266 Rylander, C. &
Sandanger, T. & Engeset D
. & Lund, E. (2014). C
onsumption of lean fish reduces the risk of type 2 diabetes m
ellitus: a prospective population based cohort study of N
orwegian w
omen. PLoS O
ne 9 (2): e89845.
267 Wu, J. &
Cahill, L. &
Mozaffarian, D
. (2013). Effect of fish oil on circulating adiponectin: a systematic review
and meta-analysis of random
ized controlled trials. The Journal of C
linical Endocrinology and Metabolism
98 (6): 2451–2459. Review.
268 Iwabu, M
. et al. (2010). Adiponectin and A
dipoR1 regulate PGC
-1alpha and mitochondria by C
a(2+) and A
MPK/SIRT1. N
ature 464 (7293): 1313–1319.
Sold to Fred Block Block (#GJ57M
BGL)
163
269 Foran J. et al. (2005). Quantitative analysis of the benefits and risks of consum
ing farmed and w
ild salmon. The Journal of N
utrition 135 (11): 2639–2643.
270 Hites, R. et al. (2004). G
lobal assessment of organic contam
inants in farmed salm
on. Science 303 (5655): 226–229.
271 Foran, J. et al. (2005). Risk-based consumption advice for farm
ed Atlantic and w
ild Pacific salmon contam
inated with dioxins and dioxin-like
compounds. Environm
ental Health Perspectives 113 (5): 552–526.
272 Fineli. (2014). Osteri, punnittu kuorineen. Terveyden ja hyvinvoinnin laitos, ravitsem
usyksikkö. <w
ww
.fineli.fi> [date of reference: 18.10.2014]
273 Holm
ström, K. (2003). A
ntibiotic use in shrimp farm
ing and implications for environm
ental impacts and hum
an health. International Journal of Food Science and Technology 38 (3): 255–256.
274 Vishwanathan, R. et al. (2009). C
onsumption of 2 and 4 egg yolks/d for 5 w
k increases macular pigm
ent concentrations in older adults with low
m
acular pigment taking cholesterol-low
ering statins. The Am
erican Journal of Clinical N
utrition 90 (5): 1272–1279.
275 Fernandez, M. (2006). D
ietary cholesterol provided by eggs and plasma lipoproteins in healthy populations. C
urrent Opinions in C
linical Nutrition and
Metabolic C
are 9 (1): 8–12. Review.
276 Rong, Y. et al. (2013). Egg consumption and risk of coronary heart disease and stroke: dose-response m
eta-analysis of prospective cohort studies. British M
edical Journal 346: e8539. Review.
277 Shin, J. & Xun, P. &
Nakam
ura, Y. & H
e, K. (2013). Egg consumption in relation to risk of cardiovascular disease and diabetes: a system
atic review and
meta-analysis. The A
merican Journal of C
linical Nutrition 98 (1): 146–159. Review
.
278 Goodrow
, E. (2006). Consum
ption of one egg per day increases serum lutein and zeaxanthin concentrations in older adults w
ithout altering serum lipid
and lipoprotein cholesterol concentrations. The Journal of Nutrition 136 (10): 2519–2524.
279 Segall, J. (1994). Dietary lactose as a possible risk factor for ischaem
ic heart disease: review of epidem
iology. International Journal of Cardiology
46 (3): 197–207.
280 Segall, J. (2002). Plausibility of dietary lactose as a coronary risk factor. Journal of Nutritional and Environm
ental Medicine 12: 217–229.
281 Moss M
. & Freed. D
. (2003). The cow and the coronary: epidem
iology, biochemistry and im
munology. International Journal of C
ardiology 87: 203–216.
282 Bonthuis, M
. & H
ughes, M. &
Ibiebele, T. & G
reen, A. &
van der Pols, J. (2010). Dairy consum
ption and patterns of mortality of A
ustralian adults. European Journal of C
linical Nutrition 64 (6): 569–577.
283 Holm
berg, S. & Thelin, A
. (2013). High dairy fat intake related to less central obesity: a m
ale cohort study with 12 years’ follow
-up. Scandinavian Journal of Prim
ary Health C
are 31 (2): 89–94.
284 Ericson, U. et al. (2014). Food sources of fat m
ay clarify the earlier inconsistent role of dietary fat intake for incidence of type 2 diabetes. The A
merican Journal of C
linical Nutrition 101 (5): 1065–1080.
285 Mozaffarian, D
. et al. (2010). Trans-Palmitoleic A
cid, Metabolic Risk Factors, and N
ew-O
nset Diabetes in U
.S. Adults. A
nnals of Internal Medicine
12: 790–799.
Sold to Fred Block Block (#GJ57M
BGL)
164
286 Bartley, J. &
McG
lashan, S. (2010). Does m
ilk increase mucus production? M
edical Hypotheses 74 (4): 732–734.
287 Lill, C. et al. (2011). M
ilk allergy is frequent in patients with chronic sinusitis and nasal polyposis. A
merican Journal of Rhinology and A
llergy
25 (6): e221–224.
288 Bolland, M
. et al. (2010). Effect of calcium supplem
ents on risk of myocardial infarction and cardiovascular events: m
eta-analysis. British M
edical Journal 341: c3691.
289 Del G
obbo, L. et al. (2013). Circulating and dietary m
agnesium and risk of cardiovascular disease: a system
atic review and m
eta-analysis of prospective studies. The A
merican Journal of C
linical Nutrition (1): 160–173. Review
.
290 Sahmoun, A
. & Singh, B
. (2010). Does a higher ratio of serum
calcium to m
agnesium increase the risk for postm
enopausal breast cancer? M
edical Hypotheses 75 (3): 315–318.
291 Kousa, A. et al. (2006). C
alcium:m
agnesium ratio in local groundw
ater and incidence of acute myocardial infarction am
ong males in rural Finland.
Environmental H
ealth Perspectives 114 (5): 730–734.
292 Michaëlsson K. et al. (2014). M
ilk intake and risk of mortality and fractures in w
omen and m
en: cohort studies. British Medical Journal 349: g6015.
293 Sodhi, M. &
Mukesh, M
. & Kataria, R. &
Mishra, B
. & Joshii, B
. (2012). Milk proteins and hum
an health: A1/A
2 milk hypothesis.
Indian Journal Endocrinology and Metabolism
16 (5): 856.
294 Ho, S. &
Woodford, K. &
Kukuljan, S. & Pal, S. (2014). C
omparative effects of A
1 versus A2 beta-casein on gastrointestinal m
easures: a blinded random
ised cross-over pilot study. European Journal of Clinical N
utrition 68 (9): 994–1000.
295 Ul H
aq, M. &
Kapila, R. & Sharm
a, R. & Saliganti, V. &
Kapila, S. (2014). Com
parative evaluation of cow β-casein variants (A
1/A2) consum
ption on Th2-m
ediated inflamm
atory response in mouse gut. European Journal of N
utrition 53 (4): 1039–1049.
296 Hebeisen, D
. (1993). Increased concentrations of omega-3 fatty acids in m
ilk and platelet rich plasma of grass-fed cow
s. International Journal of Vitam
in and Nutrition Research 63 (3): 229–233.
297 Couvreur, S. et al. (2006). The linear relationship betw
een the proportion of fresh grass in the cow diet, m
ilk fatty acid composition, and butter
properties. Journal of Dairy Science 89 (6): 1956–1969.
298 Palupi, E. & Jayanegara, A
. & Ploeger, A
. & Kahl, J. (2012). C
omparison of nutritional quality betw
een conventional and organic dairy products: a m
eta-analysis. Journal of the Science of Food and Agriculture 92 (14): 2774–2781. Review
.
299 Esmaillzadeh, A
. & M
irmiran, P. &
Azizi, F. (2005). W
hole-grain consumption and the m
etabolicsyndrome: a favorable association in Tehranian adults.
European Journal of Clinical N
utrition 59 (3): 353–362. [table 2]
300 Andersson, A
. et al. (2007). Whole-grain foods do not affect insulin sensitivity or m
arkers of lipid peroxidation and inflamm
ation in healthy, moderately
overweight subjects. The Journal of N
utrition 137 (6): 1401–1407.
Sold to Fred Block Block (#GJ57M
BGL)
165
301 Steffen L. et al. (2003). Associations of w
hole-grain, refined-grain, and fruit and vegetable consumption w
ith risks of all-cause mortality and incident
coronary artery disease and ischemic stroke: the A
therosclerosis Risk in Com
munities (A
RIC) Study. The A
merican Journal of C
linical Nutrition
78 (3): 383–390.
302 Heber, D
. (2004). Vegetables, fruits and phytoestrogens in the prevention of diseases. Journal of Postgraduate Medicine 50 (2): 145–149. Review
.
303 Fasano, A. (2011). Leaky gut and autoim
mune diseases. C
linical Reviews in A
llergy and Imm
unology 42 (1): 71–78.
304 Fasano, A. (2009). Surprises from
celiac disease. Scientific Am
erican 301: 54–61.
305 Sapone, A. et al. (2011). D
ivergence of gut permeability and m
ucosal imm
une gene expression in two gluten-associated conditions:
celiac disease and gluten sensitivity. BMC
Medicine 9: 23.
306 Catassi, C
. et al. (2013). Non-C
eliac Gluten sensitivity: the new
frontier of gluten related disorders. Nutrients 5 (10): 3839–3853.
307 Biesiekierski, J. &
Muir, J. &
Gibson, P. (2013). Is gluten a cause of gastrointestinal sym
ptoms in people w
ithout celiac disease? C
urrent Allergy and A
sthma Reports 13 (6): 631–638.
308 Sofi, F. et al. (2014). Effect of Triticum turgidum
subsp. turanicum w
heat on irritable bowel syndrom
e: a double-blinded randomised dietary
intervention trial. British Journal of Nutrition 111 (11): 1992–1999.
309 Eswaran, S. &
Goel, A
. & C
hey, W. (2013). W
hat role does wheat play in the sym
ptoms of irritable bow
el syndrome? G
astroenterology and Hepatology
9 (2): 85–91.
310 Behall, K. &
How
e, J. (1995). Effect of long-term consum
ption of amylose vs am
ylopectin starch on metabolic variables in hum
an subjects. The A
merican Journal of C
linical Nutrition 61 (2): 334–340.
311 Matsuoka, Y. et al. (2002). A
single domestication for m
aize shown by m
ultilocus microsatellite genotyping. Proceedings of the N
ational Academ
y of
Sciences of the U
nited States of Am
erica 99 (9): 6080–6084.
312 Barton, B
. & C
lark, S. (2014). Water and clim
ate risks facing U.S. corn production. H
ow com
panies and investors can cultivate sustainability. Ceres
Report. [date of reference: 25.4.2016]
313 International Grains C
ouncil. (2016). Grain M
arket Report. GM
R 465 – 28 April 2016. [date of reference: 28.4.2016]
314 Ortiz-Sánchez, J. &
Cabrera-C
hávez, F. & C
alderón de la Barca, A
M. (2013). M
aize Prolamins C
ould Induce a Gluten-Like C
ellular Imm
une Response in
Some C
eliac Disease Patients. N
utrients 25 (10): 4174–4183.
315 Goran, M
. &, U
lijaszek, S. & Ventura, E. (2013). H
igh fructose corn syrup and diabetes prevalence: a global perspective. Global Public H
ealth
8 (1): 55–64.
316 Bray, G. (2013). Potential H
ealth Risks From Beverages C
ontaining Fructose Found in Sugar or High-Fructose C
orn Syrup. Diabetes C
are 36 (1): 11–12.
317 Van Buul, V. & Tappy, L. &
Brouns, F. (2014). Misconceptions about fructose-containing sugars and their role in the obesity epidem
ic. Nutrition Research
Reviews 27 (1): 119–130.
Sold to Fred Block Block (#GJ57M
BGL)
166
318 Stanhope, K. et al. (2015). A dose-response study of consum
ing high-fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for
cardiovascular disease in young adults. The Am
erican Journal of Clinical N
utrition 101 (6): 1144–1154.
319 Esmaillzadeh, A
. & A
zadbakht, L. (2008). Hom
e use of vegetable oils, markers of system
ic inflamm
ation, and endothelial dysfunction among w
omen. The
A
merican Journal of C
linical Nutrition 88 (4): 913–921.
320 Kotimaiset kasvikset ry. (2015). Kasvisten ravintosisältö, juurekset. <
ww
w.kasvikset.fi>
[date of reference: 26.10.2014]
321 King, J. & Slavin, J. (2013). W
hite potatoes, human health, and dietary guidance. A
dvances in Nutrition 4 (3): 393S–401S. Review
.
322 Erdmann, J. &
Hebeisen, Y. &
Lippl, F. & W
agenpfeil, S. & Schusdziarra, V. (2007). Food intake and plasm
a ghrelin response during potato-, rice- and pasta-rich test m
eals. European Journal of Nutrition 46 (4): 196–203.
323 Mensinga, T. et al. (2005). Potato glycoalkaloids and adverse effects in hum
ans: an ascending dose study. Regulatory Toxicology and Pharmacology
41 (1): 66–72.
324 Bovell-B
enjamin, A
. (2007). Sweet potato: a review
of its past, present, and future role in human nutrition. A
dvances in Food and Nutrition Research
52: 1–59. Review.
325 Scott-Dixon, K. &
St.Pierre, B. (2014). Sw
eet vs. regular potatoes. Which are really healthier? Precision N
utrition. [date of reference: 26.10.2014]
326 Helldán, A
. et al. (2012). Finravinto 2012 -tutkimus. Terveyden ja hyvinvoinnin laitos. [date of reference: 5.11.2014]
327 Wang, X. et al. (2014). Fruit and vegetable consum
ption and mortality from
all causes, cardiovascular disease, and cancer: systematic review
and dose-response m
eta-analysis of prospective cohort studies. British Medical Journal 349: g4490. Review
.
328 Schweiggert, R. et al. (2014). C
arotenoids are more bioavailable from
papaya than from tom
ato and carrot in humans: a random
ised cross-over study. British Journal of N
utrition 111 (3): 490–498.
329 Brow
n, M. et al. (2004). C
arotenoid bioavailability is higher from salads ingested w
ith full-fat than with fat-reduced salad dressings as m
easured with
electrochemical detection. The A
merican Journal of C
linical Nutrition 80 (2): 396–403.
330 Lee, Y. & Low
, K. & Siah, K. &
Drum
mond, L. &
Gw
ee, K. (2012). Kiwifruit (A
ctinidia deliciosa) changes intestinal microbial profile.
Microbial Ecology in H
ealth and Disease 23.
331 Chang, C
. et al. (2010). Kiwifruit im
proves bowel function in patients w
ith irritable bowel syndrom
e with constipation.
Asia Pacific Journal of C
linical Nutrition 19 (4): 451–457.
332 Iwasaw
a, H. &
Morita, E. &
Yui, S. & Yam
azaki, M. (2011). A
nti-oxidant effects of kiwi fruit in vitro and in vivo. Biological and Pharm
aceutical Bulletin 34 (1): 128–134.
333 Kortelainen, A. (2007). Kotim
aisten ja maahantuotujen elintarvikkeiden kem
iallinen turvallisuus. Pro gradu -tutkielma. Kuopion yliopisto.
[date of reference: 4.11.2014] Sold to Fred Block Block (#GJ57M
BGL)
167
334 Kortelainen, A. (2007). Kotim
aisten ja maahantuotujen elintarvikkeiden kem
iallinen turvallisuus. Pro gradu -tutkielma. Kuopion yliopisto.
[date of reference: 24.11.2014]
335 Törhönen, R. & Riihinen, K. &
Sarkkinen, E. (2013). Selvitys marjojen terveysvaikutusten kliinisestä tutkim
usnäytöstä. Itä-Suomen yliopisto.
[date of reference: 22.11.2014]
336 Andres-Lacueva, C
. et al. (2005). Anthocyanins in aged blueberry-fed rats are found centrally and m
ay enhance mem
ory. Nutritional N
euroscience 8 (2): 111–120.
337 Basu, A
. et al. (2010). Blueberries decrease cardiovascular risk factors in obese m
en and wom
en with m
etabolic syndrome. The Journal of N
utrition 140 (9): 1582–1587.
338 Lacombe, A
. et al. (2013). Lowbush w
ild blueberries have the potential to modify gut m
icrobiota and xenobiotic metabolism
in the rat colon. PLoS O
ne 8 (6): e67497.
339 Nakaishi, H
. & M
atsumoto, H
. & Tom
inaga, S. & H
irayama, M
. (2000). Effects of black current anthocyanoside intake on dark adaptation and VDT
work-induced transient refractive alteration in healthy hum
ans. Alternative M
edicine Review 5 (6): 553–562.
340 Kalt, W. &
Hanneken, A
. & M
ilbury, P. & Trem
blay F. (2010). Recent research on polyphenolics in vision and eye health. Journal of A
gricultural and Food Chem
istry 58 (7): 4001–4007.
341 Evira. (2015). Ulkom
aiset pakastemarjat. <
ww
w.evira.fi/portal/64508>
[date of reference: 17.9.2015]
342 Story, E. & Kopec, R. &
Schwartz, S. &
Harris, G
. (2010). An update on the health effects of tom
ato lycopene. Annual Review
of Food Science and Technology 1: 189–210. Review
.
343 Macready, A
. et al. (2014). Flavonoid-rich fruit and vegetables improve m
icrovascular reactivity and inflamm
atory status in men at risk of cardiovascular
disease – FLAVU
RS: a randomized controlled trial. The A
merican Journal of C
linical Nutrition 99 (3): 479–489.
344 Park, E. J. & Pezzuto, J. M
. (2002). Botanicals in cancer chem
oprevention. Cancer M
etastasis Reviews 21 (3–4): 231–255.
345 Carter, P. et al. (2010). Fruit and vegetable intake and incidence of type 2 diabetes m
ellitus: systematic review
and meta-analysis.
British Medical Journal 341: c4229.
346 Esposito, K. & G
iugliano, D. (2011). Increased consum
ption of green leafy vegetables, but not fruit, vegetables or fruit and vegetables combined is
associated with reduced incidence of type 2 diabetes. Evidence Based M
edicine 16: 27–28.
347 Villegas, R. et al. (2008). Vegetable but not fruit consumption reduces the risk of type 2 diabetes in C
hinese wom
en. The Journal of Nutrition
138 (3): 574–580.
348 Dauchet, L. &
Am
ouyel, P. & H
ercberg, S. & D
allongeville, J. (2006). Fruit and vegetable consumption and risk of coronary heart disease:
a meta-analysis of cohort studies. The Journal of N
utrition 136 (10): 2588–2593.
349 He, F. &
Now
son, C. &
MacG
regor, G. (2006). Fruit and vegetable consum
ption and stroke: meta-analysis of cohort studies. The Lancet 367 (9507):
320–326. Review.
Sold to Fred Block Block (#GJ57M
BGL)
168
350 Wu, Q
. & Yang, Y. &
Wang, J. &
Han, L. &
Xiang, Y. (2013). Cruciferous vegetable consum
ption and gastric cancer risk: a meta-analysis of
epidemiological studies. C
ancer Science 104 (8): 1067–1073.
351 Lam, T. et al. (2010). C
ruciferous vegetable intake and lung cancer risk: a nested case-control study matched on cigarette sm
oking. Cancer
Epidemiology Biom
arkers and Prevention 19 (10): 2534–2540.
352 Li Y. et al. (2010). Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem
cells. Clinical C
ancer Research 16 (9): 2580–2590.
353 Pawlik, A
. & W
iczk, A. &
Kaczynska, A. &
Antosiew
icz, J. & H
erman-A
ntosiewicz, A
. (2013). Sulforaphane inhibits growth of phenotypically different
breast cancer cells. European Journal of Nutrition 52 (8): 1949–1958.
354 Traka M. et al. (2008). B
roccoli consumption interacts w
ith GSTM
1 to perturb oncogenic signalling pathways in the prostate. PLoS O
ne 3 (7): e2568.
355 Boddupalli, S. &
Mein, J. &
Lakkanna, S. & Jam
es, D. (2012). Induction of phase 2 antioxidant enzym
es by broccoli sulforaphane: perspectives in m
aintaining the antioxidant activity of vitamins a, C
, and e. Frontiers in Genetics 3: 7.
356 Kianbakht, S. & Khalighi-Sigaroodi, F. &
Dabaghian, F. (2013). Im
proved glycemic control in patients w
ith advanced type 2 diabetes mellitus taking
Urtica dioica leaf extract: a random
ized double-blind placebo-controlled clinical trial. Journal of Clinical Laboratory A
nalysis 59 (9–10): 1071–1076.
357 Randall, C. et al. (2000). Random
ized controlled trial of nettle sting for treatment of base-of-thum
b pain. Journal of the Royal Society of Medicine
93 (6): 305–309.
358 Chrubasik, J. &
Roufogalis, B. &
Wagner, H
. & C
hrubasik, S. (2007). A com
prehensive review on the stinging nettle effect and efficacy profiles.
Part II: urticae radix. Phytomedicine 14 (7–8): 568–579. Review
.
359 Chow
dhury, R. et al. (2014). Association of dietary, circulating, and supplem
ent fatty acids with coronary risk: a system
atic review and m
eta-analysis. A
nnals of Internal Medicine 160 (6): 398–406. Review
.
360 Harris, W
. & Shearer, G
. (2014). Om
ega-6 Fatty Acids and C
ardiovascular Disease: Friend or Foe? C
irculation Epub ahead of print.
361 Siri-Tarino, P. & Sun, Q
. & H
u, F. & Krauss, R. (2010). M
eta-analysis of prospective cohort studies evaluating the association of saturated fat with
cardiovascular disease. The Am
erican Journal of Clinical N
utrition 91 (3): 535–546.
362 Mente, A
. & de Koning, L. &
Shannon, H. &
Anand, S. (2009). A
systematic review
of the evidence supporting a causal link between dietary factors and
coronary heart disease. Archives of Internal M
edicine 169 (7): 659–669.
363 Unlu, N
. & B
ohn, T. & C
linton, S. & Schw
artz, S. (2005). Carotenoid absorption from
salad and salsa by humans is enhanced by the addition of
avocado or avocado oil. The Journal of Nutrition 135 (3): 431–436.
364 Lipoeto, N. &
Agus, Z. &
Oenzil, F. &
Wahlqvist, M
. & W
attanapenpaiboon, N. (2004). D
ietary intake and the risk of coronary heart disease among
the coconut-consuming M
inangkabau in West Sum
atra, Indonesia. Asia Pacific Journal of C
linical Nutrition 13 (4): 377–384.
365 Intahphuak, S. & Khonsung, P. &
Panthong, A. (2010). A
nti-inflamm
atory, analgesic, and antipyretic activities of virgin coconut oil. Pharmacological
Biology 48 (2): 151–157.
Sold to Fred Block Block (#GJ57M
BGL)
169
366 Arunim
a, S. & Rajam
ohan, T. (2014). Influence of virgin coconut oil-enriched diet on the transcriptional regulation of fatty acid synthesis and oxidation in rats – a com
parative study. British Journal of Nutrition 111 (10): 1782–1790.
367 Couvreur, S. et al. (2006). The linear relationship betw
een the proportion of fresh grass in the cow diet, m
ilk fatty acid composition, and butter
properties. Journal of Dairy Science 89 (6): 1956–1969.
368 Russo, I. & Luciani, A
. & D
e Cicco. P. &
Troncone, E. & C
iacci, C. (2012). B
utyrate attenuates lipopolysaccharide-induced inflamm
ation in intestinal cells and C
rohn’s mucosa through m
odulation of antioxidant defense machinery. PLoS O
ne 7 (3): e32841.
369 Ohira, H
. et al. (2013). Butyrate attenuates inflam
mation and lipolysis generated by the interaction of adipocytes and m
acrophages. Journal of A
therosclerosis and Thrombosis 20 (5): 425–442.
370 Beaucham
p, G. et al. (2005). Phytochem
istry: ibuprofen-like activity in extra-virgin olive oil. Nature 437 (7055): 45–46.
371 Cicerale, S. &
Lucas, L. & Keast, R. (2010). B
iological activities of phenolic compounds present in virgin olive oil. International Journal of M
olecular Sciences 11 (2): 458–479.
372 Lucas, L. & Russell, A
. & Keast, R. (2011). M
olecular mechanism
s of inflamm
ation. Anti-inflam
matory benefits of virgin olive oil and the phenolic
compound oleocanthal. C
urrent Pharmaceutical D
esign 17 (8): 754–768. Review.
373 Parkinson, L. & Keast, R. (2014). O
leocanthal, a phenolic derived from virgin olive oil: a review
of the beneficial effects on inflamm
atory disease. International Journal M
olecular Sciences 15 (7): 12323–12334.
374 Psaltopoulou, T. & Kosti, R. &
Haidopoulos, D
. & D
imopoulos, M
. & Panagiotakos, D
. (2011). Olive oil intake is inversely related to cancer prevalence:
a systematic review
and a meta-analysis of 13,800 patients and 23,340 controls in 19 observational studies. Lipids in H
ealth and Disease 10: 127.
375 Guasch-Ferré, M
. et al. (2014). Olive oil intake and risk of cardiovascular disease and m
ortality in the PREDIM
ED Study. BM
C M
edicine 12: 78.
376 Buckland, G. et al. (2012). O
live oil intake and mortality w
ithin the Spanish population (EPIC-Spain). A
merican Journal of C
linical Nutrition 96 (1): 142–149.
377 De N
icoló, S. et al. (2013). Effects of olive polyphenols administration on nerve grow
th factor and brain-derived neurotrophic factor in the mouse brain.
Nutrition 29 (4): 681–687.
378 Valls-Pedret, C. et al. (2012). Polyphenol-rich foods in the M
editerranean diet are associated with better cognitive function in elderly subjects at high
cardiovascular risk. Journal of Alzheim
ers Disease 29 (4): 773–782.
379 García-H
ernández, V. et al. (2013). Effect of omega-3 dietary supplem
ents with different oxidation levels in the lipidic profile of w
omen:
a randomized controlled trial. International Journal of Food Sciences and N
utrition 64 (8): 993–1000.
380 Fontani, G. et al. (2005). C
ognitive and physiological effects of Om
ega-3 polyunsaturated fatty acid supplementation in healthy subjects.
European Journal of Clinical Investigation 35 (11): 691–699.
381 Grosso, G
. et al. (2014). Role of omega-3 fatty acids in the treatm
ent of depressive disorders: a comprehensive m
eta-analysis of randomized clinical
trials. PLoS One 9 (5): e96905. Sold to Fred Block Block (#G
J57MBG
L)
170
382 Serhan, C. (2014). Pro-resolving lipid m
ediators are leads for resolution physiology. Nature 510 (7503): 92–101. Review
.
383 Stonehouse, W. et al. (2013). D
HA
supplementation im
proved both mem
ory and reaction time in healthy young adults: a random
ized controlled trial. A
merican Journal of C
linical Nutrition 97 (5): 1134–1143.
384 Cole, G
. & Frautschy, S. (2010). D
HA
may prevent age-related dem
entia. The Journal of Nutrition 140 (4): 869–874.
385 Yurko-Mauro, K. (2010). C
ognitive and cardiovascular benefits of docosahexaenoic acid in aging and cognitive decline. Current A
lzheimer Research
7 (3): 190–196. Review.
386 Wen, Y. &
Dai, J. &
Gao, Q
. (2014). Effects of Om
ega-3 fatty acid on major cardiovascular events and m
ortality in patients with coronary heart disease:
a meta-analysis of random
ized controlled trials. Nutrition M
etabolism and C
ardiovascular Diseases 24 (5): 470–475.
387 Kotwal, S. &
Jun, M. &
Sullivan, D. &
Perkovic, V. & N
eal, B. (2012). O
mega 3 Fatty acids and cardiovascular outcom
es: systematic review
and m
eta-analysis. Circulation: C
ardiovascular Quality and O
utcomes 5 (6): 808–888.
388 Miller, P. &
Van Elswyk, M
. & A
lexander, D. (2014). Long-chain om
ega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid and blood pressure: a m
eta-analysis of randomized controlled trials. A
merican Journal of H
ypertension 27 (7): 885–896.
389 Bernstein, A
. & D
ing, E. & W
illett, W. &
Rimm
, E. (2012). A m
eta-analysis shows that docosahexaenoic acid from
algal oil reduces serum triglycerides
and increases HD
L-cholesterol and LDL-cholesterol in persons w
ithout coronary heart disease. The Journal of Nutrition 142 (1): 99–104.
390 Larsson, S. & O
rsini, N. &
Wolk, A
. (2012). Long-chain omega-3 polyunsaturated fatty acids and risk of stroke: a m
eta-analysis. European Journal of Epidem
iology 27 (12): 895–901.
391 Kris-Etherton P. et al. (2000). Polyunsaturated fatty acids in the food chain in the United States. The A
merican Journal of C
linical Nutrition
71 (1 Suppl): 179S–188S. Review.
392 Simopoulos, A
. (2002). The importance of the ratio of om
ega-6/omega-3 essential fatty acids. Biom
edicine and Pharmacotherapy 56 (8): 365–379. Review
.
393 Kelly, J. Jr. & Sabaté, J. (2006). N
uts and coronary heart disease: an epidemiological perspective. British Journal of N
utrition 96 Suppl 2: S61–67. Review.
394 Guasch-Ferré, M
. et al. (2013). Frequency of nut consumption and m
ortality risk in the PREDIM
ED nutrition intervention trial. BM
C M
edicine 11: 164.
395 Bao, Y. et al. (2013). A
ssociation of nut consumption w
ith total and cause-specific mortality. N
ew England Journal of M
edicine 369 (21): 2001–2011.
396 Torabian S. & H
addad E. & Rajaram
S. & B
anta J. & Sabaté J. (2009). A
cute effect of nut consumption on plasm
a total polyphenols, antioxidant capacity and lipid peroxidation. Journal of H
uman N
utrition and Dietetics 22 (1): 64–71.
397 Ukhanova, M
. et al. (2014). Effects of almond and pistachio consum
ption on gut microbiota com
position in a randomised cross-over hum
an feeding study. British Journal of N
utrition 111 (12): 2146–2152.
398 Kendall, C. &
Josse, A. &
Esfahani, A. &
Jenkins, D. (2011). The im
pact of pistachio intake alone or in combination w
ith high-carbohydrate foods on post-prandial glycem
ia. European Journal of Clinical N
utrition 65 (6): 696–702.
Sold to Fred Block Block (#GJ57M
BGL)
171
399 Kocyigit, A. &
Koylu, A. &
Keles, H. (2006). Effects of pistachio nuts consum
ption on plasma lipid profile and oxidative status in healthy volunteers.
Nutrition M
etabolism and C
ardiovascular Disease 16 (3): 202–209.
400 Thomson, C
. & C
hisholm, A
. & M
cLachlan, S. & C
ampbell, J. (2008). B
razil nuts: an effective way to im
prove selenium status.
The Am
erican Journal of Clinical N
utrition 87 (2): 379–384.
401 Iwam
oto, M. et al. (2000). W
alnuts lower serum
cholesterol in Japanese men and w
omen. The Journal of N
utrition 130 (2): 171–176.
402 Tan, S. & M
attes, R. (2013). Appetitive, dietary and health effects of alm
onds consumed w
ith meals or as snacks: a random
ized, controlled trial. European Journal of C
linical Nutrition 67 (11): 1205–1214.
403 Wien, M
. et al. (2010). Alm
ond consumption and cardiovascular risk factors in adults w
ith prediabetes. Journal of Am
erican College of N
utrition 29 (3): 189–197.
404 Josse, A. et al. (2007). A
lmonds and postprandial glycem
ia – A dose-response study. M
etabolism 56 (3): 400–404.
405 Jalali-Khanabadi, B. &
Mozaffari-Khosravi, H
. & Parsaeyan, N
. (2010). Effects of almond dietary supplem
entation on coronary heart disease lipid risk factors and serum
lipid oxidation parameters in m
en with m
ild hyperlipidemia. The Journal of A
lternative and Com
plementary M
edicine 16 (12): 1279–1283.
406 Hudthagosol, C
. et al. (2011). Pecans acutely increase plasma postprandial antioxidant capacity and catechins and decrease LD
L oxidation in humans.
The Journal of Nutrition 141 (1): 56–62.
407 Garg, M
. & B
lake, R. & W
ills, R. & C
layton, E. (2007). Macadam
ia nut consumption m
odulates favourably risk factors for coronary artery disease in hypercholesterolem
ic subjects. Lipids 42 (6): 583–587.
408 Griel, A
. et al. (2008). A m
acadamia nut-rich diet reduces total and LD
L-cholesterol in mildly hypercholesterolem
ic men and w
omen.
The Journal of Nutrition 138 (4): 761–767.
409 Frazier, A. et al. (2013). Prospective study of peripregnancy consum
ption of peanuts or tree nuts by mothers and the risk of peanut or tree nut allergy
in their offspring. JAM
A Pediatrics 168 (2): 156–162.
410 Macfarlane, B
. (1988). Inhibitory effect of nuts on iron absorption. The Am
erican Journal of Clinical N
utrition 47 (2): 270–274.
411 Dahl, W
. & Lockert, E. &
Cam
mer, A
. & W
hiting, S. (2005). Effects of flax fiber on laxation and glycemic response in healthy volunteers.
Journal of Medicinal Food 8 (4): 508–511.
412 Mohd A
li, N. et al. (2012). The prom
ising future of chia, Salvia hispanica L. Journal of Biomedicine and Biotechnology 2012: 171956.
413 Illian, T. & C
asey, J. & B
ishop, P. (2011). Om
ega 3 Chia seed loading as a m
eans of carbohydrate loading. Journal of Strength and Conditioning
Research 25 (1): 61–65.
414 Glew
, R. et al. (2006). Am
ino acid, mineral and fatty acid content of pum
pkin seeds (Cucurbita spp) and C
yperus esculentus nuts in the Republic of N
iger. Plant Foods for Hum
an Nutrition 61 (2): 51–56.
Sold to Fred Block Block (#GJ57M
BGL)
172
415 House, J. &
Neufeld, J. &
Leson, G. (2010). Evaluating the quality of protein from
hemp seed (C
annabis sativa L.) products through the use of the protein digestibility-corrected am
ino acid score method. Journal of A
gricultural And Food C
hemistry 58 (22): 11801–11807.
416 Pasman, W
. J. et al. (2008). The effect of Korean pine nut oil on in vitro CC
K release, on appetite sensations and on gut hormones in post-m
enopausal overw
eight wom
en. Lipids in Health D
isease 7: 10.
417 Reagor, L. et al. (2002). The effectiveness of processed grapefruit-seed extract as an antibacterial agent: I. An in vitro agar assay.
The Journal of Alternative and C
omplem
entary Medicine 8 (3): 325–332.
418 Flora, K. & H
ahn, M. &
Rosen, H. &
Benner, K. (1998). M
ilk thistle (Silybum m
arianum) for the therapy of liver disease.
The Am
erican Journal of Gastroenterology 93 (2): 139–143. Review
.
419 Cacciapuoti, F. et al. (2013). Silym
arin in non alcoholic fatty liver disease. World Journal of H
epatology 5 (3): 109–113.
420 Braidy N
. et al. (2013). Neuroprotective effects of a variety of pom
egranate juice extracts against MPTP-induced cytotoxicity and oxidative stress
in human prim
ary neurons. Oxidative M
edicine and Cellular Longevity 685909.
421 Iacobellis, N. &
Lo Cantore, P. &
Capasso, F. &
Senatore, F. (2005). Antibacterial activity of C
uminum
cyminum
L. and Carum
carvi L. essential oils. Journal of A
gricultural and Food Chem
istry 53 (1): 57–61.
422 Akibode, S. &
Maredia, M
. (2011). Global and Regional Trends in Production, Trade and C
onsumption of Food Legum
e Crops. M
ichigan State
University, D
epartment of A
gricultural, Food and Resource Economics 1–83. [date of reference: 29.12.2015]
423 Vidal-Valverde, C. &
Frías, J. & Valverde, S. (1993). C
hanges in the carbohydrate composition of legum
es after soaking and cooking. Journal of the
A
merican D
ietetic Association 93 (5): 547–550.
424 Sontag-Strohm, T. &
Lampi, A
-M. &
Piironen, V. & Salovaara, H
. & Stoddard, F. (2012). Pavut valtaavat tilaa kuluttajien ruokalautasella. Kehittyvä
Elintarvike 23 (2): 30–31.
425 Doria, E. &
Sparvoli, F. & Tava, A
. (2012). Anti-nutrient com
ponents and metabolites w
ith health implications in seeds of 10 com
mon bean (Phaseolus
vulgaris L. and Phaseolus lunatus L.) landraces cultivated in southern Italy. Journal of Food C
omposition and A
nalysis 26: 72–80.
426 Zhu, B. &
Sun, Y. & Q
i, L. & Zhong, R. &
Miao, X. (2015). D
ietary legume consum
ption reduces risk of colorectal cancer: evidence from a m
eta-analysis
of cohort studies. Science Reports 5: 8797.
427 Messina, M
. (1999). Legumes and soybeans: overview
of their nutritional profiles and health effects. The Am
erican Journal of Clinical N
utrition 70 (3
Suppl): 439S–450S. Review
.
428 Salehi-Abargouei, A
. & Saraf-B
ank, S. & B
ellissimo, N
. & A
zadbakht, L. (2015). Effects of non-soy legume consum
ption on C-reactive protein:
a system
atic review and m
eta-analysis. Nutrition 31 (5): 631–639.
429 Jayalath, V. et al. (2014). Effect of dietary pulses on blood pressure: a systematic review
and meta-analysis of controlled feeding trials.
A
merican Journal of H
ypertension 27 (1): 56–64.
Sold to Fred Block Block (#GJ57M
BGL)
173
430 Bazzano, LA
. & Thom
pson, A. &
Tees, M. &
Nguyen, C
. & W
inham, D
. (2011). Non-soy legum
e consumption low
ers cholesterol levels: a meta-analysis
of random
ized controlled trials. Nutrition, M
etabolism and C
ardiovascular Diseases 21 (2): 94–103.
431 Pusztai, A. &
Grant, G
. (1998). Assessm
ent of lectin inactivation by heat and digestion. Methods in M
olecular Medicine 9: 505–514.
432 Pusztai, A. (1993). D
ietary lectins are metabolic signals for the gut and m
odulate imm
une and hormone functions. European Journal of C
linical
Nutrition 47 (10): 691–699. Review
.
433 Ryder, S. & Jacyna, M
. & Levi, A
. & Rizzi, P. &
Rhodes, J. (1998). Peanut ingestion increases rectal proliferation in individuals with m
ucosal expression of
peanut lectin receptor. Gastroenterology 114 (1): 44–49.
434 Wang, Q
. & Yu, L. &
Cam
pbell, B. &
Milton, J. &
Rhodes, J. (1998). Identification of intact peanut lectin in peripheral venous blood. Lancet 352 (9143):
1831–1832.
435 Kritchevsky, D. &
Tepper, S. & Klurfeld, D
. (1998). Lectin may contribute to the atherogenicity of peanut oil. Lipids 33 (8): 821–823.
436 U.S Food and D
rug Adm
inistration. (2006). FDA
Poisonous Plant Database: Soy. D
epartment of H
ealth and Hum
an Science. [date of reference: 30.12.2015]
437 Gilani, G
. & C
ockell, K. & Sepehr, E. (2005). Effects of antinutritional factors on protein digestibility and am
ino acid availability in foods. Journal of
A
OA
C International 88 (3): 967–987. Review
.
438 Hooper, L. et al. (2009). Effects of soy protein and isoflavones on circulating horm
one concentrations in pre- and post-menopausal w
omen: a system
atic
review and m
eta-analysis. Hum
an Reproduction Update 15 (4): 423–440.
439 Messina, M
. & Redm
ond, G. (2006). Effects of soy protein and soybean isoflavones on thyroid function in healthy adults and hypothyroid patients: a
review of the relevant literature. Thyroid 16 (3): 249–258. Review
.
440 Chavarro, J. &
Toth, T. & Sadio, S. &
Hauser, R. (2008). Soy food and isoflavone intake in relation to sem
en quality parameters am
ong men from
an
infertility clinic. H
uman Reproduction 23 (11): 2584–2590.
441 Grace, P. et al. (2004). Phytoestrogen concentrations in serum
and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast
cancer risk in European prospective investigation of cancer and nutrition-norfolk. C
ancer Epidemiological Biom
arkers and Prevention 13 (5): 698–708.
442 de Lemos, M
. (2001). Effects of soy phytoestrogens genistein and daidzein on breast cancer growth. The A
nnals of Pharmacotherapy 35 (9): 1118–1121.
Review
.
443 Johnson, I. & G
ee, J. & Price, K. &
Curl, C
. & Fenw
ick, G. (1986) Influence of saponins on gut perm
eability and active nutrient transport in vitro.
The Journal of Nutrition 116 (11): 2270–2277.
444 Baum
ann, E. et al. (2000). Hem
olysis of human erythrocytes w
ith saponin affects the mem
brane structure. Acta H
istochemica 102 (1): 21–35.
445 USD
A. (2015). A
doption of Genetically Engineered C
rops in the U.S. Econom
ic Research Service. [date of reference: 1.1.2016]
446 Paul, B. &
Snyder, S. (2010). The unusual amino acid L-ergothioneine is a physiologic cytoprotectant. C
ell Death and D
ifferentiation 17 (7): 1134–1140.
Sold to Fred Block Block (#GJ57M
BGL)
174
447 Lindequist, U. &
Niederm
eyer, T. & Jüllich, W
. (2005). The Pharmacological Potential of M
ushrooms. Evidence-based C
omplem
entary and Alternative
Medicine 2 (3): 285–299.
448 Rogers. R. (2011). The Fungal Pharmacy: The C
omplete G
uide to Medicinal M
ushrooms and Lichens of N
orth Am
erica. North A
tlantic Books.
449 Ganeshpurkar, A
. & Rai, G
. & Jain, A
. (2010). Medicinal m
ushrooms: Tow
ards a new horizon. Pharm
acognosy Reviews 4 (8): 127–135.
450 Evira. (2010). Myrkylliset sienet. Elintarviketurvallisuusvirasto Evira. [date of reference: 29.11.2014]
451 Evira. (2008). Sienten käsittelyohjeet. Radioaktiivisen cesiumin vähentäm
inen. STUK ja Evira. [date of reference: 29.11.2014]
452 Niem
inen, P. & Kirsi, M
. & M
ustonen, A. M
. (2006). Suspected myotoxicity of edible w
ild mushroom
s. Experimental Biology and M
edicine 231 (2): 221–228.
453 Beelm
an, R. & Kalaras, M
. (2009). Post-harvest Vitamin D
Enrichment of Fresh M
ushrooms. H
AL Project #M
U07018, Penn State U
niversity.
454 Gleeson, T. &
Wada, Y. &
Bierkens, M. &
van Beek, L. (2012). Water balance of global aquifers revealed by groundw
ater footprint. N
ature 488 (7410): 197–200.
455 World W
ater Assessm
ent Programm
e. (2003). Water for People, W
ater for Life. The United N
ations World W
ater Developm
ent Report. UN
ESCO
. [date of reference: 29.11.2014]
456 Hakulinen, P. (2006). Experim
ental studies on cellular mechanism
s of the carcinogenicity of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H
)-furanone (MX).
Kansanterveyslaitos, väitöstutkimus. [date of reference: 30.11.2014]
457 Pekkarinen. A. (2014). Putkien syöpym
inen on monen talon ongelm
a. Suomen Kiinteistölehti. [date of reference: 29.11.2014]
458 Vesi- ja viemärilaitosyhdistys. (2009). Kiinteistöjen m
etallisten käyttövesiputkistojen ja -laitteistojen kestävyys. Tiivistelmäraportti. FC
G Planeko O
Y. [date of reference: 29.11.2014]
459 Kousa, A. et al. (2006). C
alcium:m
agnesium ratio in local groundw
ater and incidence of acute myocardial infarction am
ong males in rural Finland.
Environmental H
ealth Perspectives 114 (5): 730–734.
460 Valsta, L. et al. (2008). Juomat ravitsem
uksessa. Valtion ravitsemusneuvottelukunnan raportti. [date of reference: 30.11.2014]
461 Wagner, M
. & O
ehlmann, J. (2009). Endocrine disruptors in bottled m
ineral water: total estrogenic burden and m
igration from plastic bottles.
Environmental Science and Pollution Research 16 (3): 278–286.
462 Higdon, J. &
Frei, B. (2006). Coffee and health: a review
of recent human research. C
ritical Reviews in Food Science and N
utrition 46 (2): 101–123. Review.
463 Ding, M
. et al. (2014). Caffeinated and decaffeinated coffee consum
ption and risk of type 2 diabetes: a systematic review
and a dose-response m
eta-analysis. Diabetes C
are 37 (2): 569–586.
464 Ding, M
. et al. (2014). Long-term coffee consum
ption and risk of cardiovascular disease: a systematic review
and a dose-response meta-analysis of
prospective cohort studies. Circulation 129 (6): 643–659.
Sold to Fred Block Block (#GJ57M
BGL)
175
465 Crippa, A
. & D
iscacciati, A. &
Larsson, S. & W
olk, A. &
Orsini, N
. (2014). Coffee consum
ption and mortality from
all causes, cardiovascular disease, and cancer: a dose-response m
eta-analysis. Am
erican Journal of Epidemiology 180 (8): 763–775.
466 Wang, Y. &
Ho, C
. (2009). Polyphenolic chemistry of tea and coffee: a century of progress. Journal of A
griculture and Food Chem
istry 57 (18): 8109–8114. Review
.
467 Djordjevic, N
. & G
hotbi, R. & Jankovic, S. &
Aklillu, E. (2010). Induction of C
YP1A2 by heavy coffee consum
ption is associated with the
CYP1A
2 -163C>
A polym
orphism. European Journal of C
linical Pharmacology 66 (7): 697–703.
468 Suarez-Quiroz M
. et al. (2005). Effect of the post-harvest processing procedure on OTA
occurrence in artificially contaminated coffee.
International Journal of Food Microbiology 103 (3): 339–345.
469 Viani, R. (2002). Effect of processing on ochratoxin A (O
TA) content of coffee. A
dvances in Experimental M
edicine and Biology 504: 189–193. Review.
470 van der Stegen, G. &
Essens, P. & van der Lijn, J. (2001). Effect of roasting conditions on reduction of ochratoxin a in coffee.
Journal of Agricultural and Food C
hemistry 49 (10): 4713–4715.
471 Tullilaboratorio. (2012). Mykotoksiinit. Suom
en tulli. [date of reference: 28.11.2014]
472 European Coffee C
o-operation. (2006). Quality C
ontrol System for C
offee with respect to O
ccurrence of Ochratoxin A
in the coffee chain. European C
offee Co-operation Task Force. [date of reference: 28.11.2014]
473 Hicks, M
. & H
siesh, Y. (1996). Tea preparation and its influence on methylxanthine concentration. Food Research International 29 (3–4): 325–330.
474 Schwalfenberg, G
&, G
enuis, S. & Rodushkin, I. (2013). The benefits and risks of consum
ing brewed tea: bew
are of toxic element contam
ination. Journal of Toxicology 2013: 370460.
475 Ow
en, G. &
Parnell, H. &
De B
ruin, E. & Rycroft, J. (2008). The com
bined effects of L-theanine and caffeine on cognitive performance and m
ood. N
utritional Neuroscience 11 (4): 193–198.
476 Peng, X. et al. (2014). Effect of green tea consumption on blood pressure: a m
eta-analysis of 13 randomized controlled trials. Scientific Reports 4: 6251
477 Khalesi, S. et al. (2014). Green tea catechins and blood pressure: a system
atic review and m
eta-analysis of randomised controlled trials.
European Journal of Nutrition 53 (6): 1299–1311.
478 Onakpoya, I. &
Spencer, E. & H
eneghan, C. &
Thompson, M
. (2014). The effect of green tea on blood pressure and lipid profile: a systematic review
and m
eta-analysis of randomized clinical trials. N
utrition Metabolism
and Cardiovascular D
isease 24 (8): 823–836.
479 Liu, K. et al. (2013). Effect of green tea on glucose control and insulin sensitivity: a meta-analysis of 17 random
ized controlled trials. The A
merican Journal of C
linical Nutrition 98 (2): 340–348.
480 Boehm
, K. et al. (2009). Green tea (C
amellia sinensis) for the prevention of cancer. C
ochrane Database of System
atic Reviews (3): C
D005004. Review
.
Sold to Fred Block Block (#GJ57M
BGL)
176
481 Hodgson, A
. & Randell, R. &
Jeukendrup, A. (2013). The effect of green tea extract on fat oxidation at rest and during exercise: evidence of efficacy
and proposed mechanism
s. Advances in N
utrition 4 (2): 129–40. Review.
482 Giulian, R. et al. (2007). Elem
ental characterization of comm
ercial mate tea leaves (Ilex paraguariensis A
. St.-Hil.) before and after hot w
ater infusion using ion beam
techniques. Journal of Agriculture and Food C
hemistry 55 (3): 741–746.
483 Reis Ede, M. et al. (2014). A
ntidepressant-Like Effect of Ilex paraguariensis in Rats. Biomed Research International 2014: 958209.
484 Bracesco, N
. & Sanchez, A
. & C
ontreras, V. & M
enini, T. & G
ugliucci, A. (2011). Recent advances on Ilex paraguariensis research: m
inireview.
Journal of Ethnopharmacology 136 (3): 378–384.
485 Pereira, D. et al. (2012). Influence of the traditional B
razilian drink Ilex, paraguariensis tea on glucose homeostasis. Phytom
edicine 19 (10): 868–877.
486 Chiang, C
. et al. (2005). Pu-erh tea supplementation suppresses fatty acid synthase expression in the rat liver through dow
nregulating Akt and
JNK signalings as dem
onstrated in human hepatom
a HepG
2 cells. Oncology Research 16 (3): 119–128.
487 Lin, J. & Lin-Shiau, S. (2006). M
echanisms of hypolipidem
ic and anti-obesity effects of tea and tea polyphenols. Molecular N
utrition and Food Research 50 (2): 211–217. Review
.
488 Kuo, K. et al. (2005). Com
parative studies on the hypolipidemic and grow
th suppressive effects of oolong, black, pu-erh, and green tea leaves in rats. Journal of A
gricultural and Food Chem
istry 53 (2): 480–489.
489 Yi, D. et al. (2014). Reduced risk of dyslipidaem
ia with oolong tea consum
ption: a population-based study insouthern China.
British Journal of Nutrition 111 (8): 1421–1429.
490 Hossain, S. &
Aoshim
a, H. &
Koda, H. Kiso, Y. (2004). Fragrances in oolong tea that enhance the response of G
AB
AA
receptors. Bioscience Biotechnology and Biochem
istry 68 (9): 1842–1848.
491 Unachukw
u, U. &
, Ahm
ed, S. & Kavalier, A
. & Lyles, J. &
Kennelly, E. (2010). White and green teas (C
amellia sinensis var. sinensis):
variation in phenolic, methylxanthine, and antioxidant profiles. Journal of Food Science 75 (6): C
541–548.
492 Arab, L. &
Khan, F. & Lam
, H. (2013). Tea consum
ption and cardiovascular disease risk. The Am
erican Journal of Clinical N
utrition 98 (6 Suppl): 1651S–1659S. Review
.
493 Miura, Y. et al. (2001). Tea catechins prevent the developm
ent of atherosclerosis in apoprotein E-deficient mice. The Journal of N
utrition 131 (1): 27–32.
494 Arab, L. &
Liebeskind, D. (2010). Tea, flavonoids and stroke in m
an and mouse. A
rchives of Biochemistry and Biophysics 501 (1): 31–36. Review
.
495 Cam
ouse, M. et al. (2009). Topical application of green and w
hite tea extracts provides protection from solar-sim
ulated ultraviolet light in human skin.
Experimental D
ermatology 18 (6): 522–526.
496 Thring, T., & H
ili, P. & N
aughton, D. (2009). A
nti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants. BM
C C
omplem
entary and A
lternative Medicine 9: 27.
Sold to Fred Block Block (#GJ57M
BGL)
177
497 Lorenz, M. et al. (2007). A
ddition of milk prevents vascular protective effects of tea. European H
eart Journal 28 (2): 219–223.
498 Huttunen, J. (2012). A
lkoholi ja terveys. Lääkärikirja Duodecim
. [date of reference: 3.12.2014]
499 Neafsey, E. &
Collins, M
. (2011). Moderate alcohol consum
ption and cognitive risk. Neuropsychiatric D
isease and Treatment 7: 465–484.
500 Li, S. et al. (2014). Effects of herbal infusions, tea and carbonated beverages on alcohol dehydrogenase and aldehyde dehydrogenase activity. Food and Function 5 (1): 42–49.
501 Kaviarasan, S. & Visw
anathan, P. & A
nuradha, C. V. (2007). Fenugreek seed (Trigonella foenum
graecum) polyphenols inhibit ethanol-induced collagen
and lipid accumulation in rat liver. C
ell Biology and Toxicology 23 (6): 373–383.
502 Lee, M. et al. (2014). Red ginseng relieves the effects of alcohol consum
ption and hangover symptom
s in healthy men: a random
ized crossover study. Food and Function 5 (3): 528–534.
503 Ushida, Y. &
Talalay, P. (2013). Sulforaphane accelerates acetaldehyde metabolism
by inducing aldehyde dehydrogenases: relevance to ethanol intolerance. A
lcohol and Alcoholism
48 (5): 526–534.
Sold to Fred Block Block (#GJ57M
BGL)
178
Did you find this chapter on nutrition useful?
Would you like to attend a w
ebinar or a public event
where w
e discuss the topics of the book?
Would you like to receive new
chapters of the book as
they are published?
Would you like to pre-order the upcom
ing book?
We w
ould really appreciate it if you shared the book’s
homepage, w
ww
.biohacking
book.com
, with your
friends, on social media, via e-m
ail, or by any other
means.
The feedback form and com
plementary m
aterial to the
book is available in the following address:
We are grateful for your existence.
Best w
ishes,
Teemu A
rina, Jaakko Halm
etoja ja Olli Sovijärvi
ww
w.b
iohackingb
ook.com
Share the book w
ith your friends
and join the B
iohacker’s New
sletter
biohack.to/nutrition
Sold to Fred Block Block (#GJ57M
BGL)