Hand(ednes)s on an old ligand.Two research groups report on different ways of modifying the Cp ligand so that Rh(III)-catalyzed C-H functionalization (A) would create preferred enantiomeric

products (R and R′ are organic substituents; the star marks the product's chiral carbon).

H Wang, F Glorius Science 2012;338:479-480

Published by AAAS

Fig. 1 Conceptual design of the chiral Cpx* complexes.

B Ye, N Cramer Science 2012;338:504-506

Published by AAAS

Fig. 2 Structure of the chiral Cpx*Rh(I) complexes 1a to 1f.

B Ye, N Cramer Science 2012;338:504-506

Published by AAAS

Fig. 3 Postulated model for the stereochemical preference with complex 1c.

B Ye, N Cramer Science 2012;338:504-506

Published by AAAS