gynecologic emergencies. ectopic pregnancy definition ectopic pregnancy- implantation outside of the...
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GYNECOLOGIC EMERGENCIES
Ectopic pregnancy
DEFINITION Ectopic pregnancy- implantation outside of
the uterine cavity The most common reason of
peritoneal signs in gynecology
Frequency of ectopic pregnancy in Europe
1-2: 100
Types of ectopic pregnancy by location
• Ampullary 78% • Isthmic 12% 95% „tubal pregnancy”• Fimbrial 5%• Interstitial 2-3% • Ovarian 1% (3% after ART)• Abdominal 1-2% (high mortality)• Cervical 0,5%
Risk factors for ectopic pregnancy
• (30-50%) Salpingitis; PID (Chlamydia trachomatis!!!)
damage for such infection may retard the passage of the fertilized ovum through the tube to the endometrial cavity
• Operations a) surgery of fallopian tubesb) plastic reconstruction of fallopian tubes
• ART– ovarian stimulation – embryo transfer reflux
• Previous ectopic pregnancy• Age 35-45
Risk factors for ectopic pregnancy
• Contraception ??? • Endometriosis• Congenital defects of fallopian tubes • Psychical spasm of fallopian tubes • Smoking • Multiparous women • Black and Hispanic women
• Idiopatic
Symptoms of unrupted ectopic pregnancy
Very different - depends of location and development of ectopic pregnancy
• Abdominal/pelvic pain- unilateral or bilateral; intermittent or constant
• Amenorrhea • Pregnancy symptoms • Vaginal bleeding • Pregnancy test or HCG
Gynecological examination
• Adnexal tenderness• Cervical motion tenderness• Adnexal mass • Uterus- normal size (70%) or enlarged
(30%) • Hemoperitoneum; convexity of cul-de-sac
Ectopic pregnancyDiagnosis
1.Pregnancy test - detects level of HCG (Human Chorionic Gonadotropin)
a) 5 days after conception – serum assaysb) 14 days after conception – urinary tests
HCG < 10 mIU/ml – no pregnancy HCG > 25 mIU/ml – pregnancy 4-5 Hbd HCG > 750 mIU/ml (or 1000 mIU/ml) and visible in USG
Early pregnancy- up to 6 weeks • Increasing of HCG > 66% in 48 hours • Increasing of HCG > 114% in 72 hours • Increasing of HCG > 175% in 96 hours
Ectopic pregnancyDiagnosis
2. USG:
• 4-5 weeks of pregnancy- visible in USG
• Enlarged size of fallopian tube
• Empty uterine cavity
• Large endometrium
Ectopic pregnancyDiagnosis
3. Progesterone (always with HCG and USG)
• > 25ng/ml - normal pregnancy
• < 5 ng/ml - ectopic pregnancy or obsolete pregnancy
4. high concentration of:
Estradiol; Il 6; Il 8; TNFα; creatine kinase
The most common symptom of ruptured ectopic pregnancy
Hemoperitoneum
Symptoms of ruptured ectopic pregnancy
• Hypovolemic shock- a decrease in blood pressure and an increase in pulse
• Syncope• Acute abdominal pain • Temperature > 37º C • Urge to defecate or urinary urge • Vomiting • Peritoneal signs- hemoperitoneum • Irritation of the diaphragm- shoulder pain
Differential Diagnosis of Ectopic Pregnancy
• any woman of reproductive age with- acute pelvic or lower abdominal pain - abnormal bleeding - amenorrhea
• complications of intrauterine pregnancy (complited or incomplited abortion)
• acute or chronic salpingitis
Differential Diagnosis of Ectopic Pregnancy
• Follicular or corpus luteum cyst rupture
• Endometriosis
• Adnexal torsion
• Gastroenteritis
• Appendecitis
Combined pregnancy (heterotopic pregnancy)
• intrauterine and extrauterine gestations
1: 30 000• after ART
1: 100
approximately 1 in 3 of the intrauterine pregnancies are reproted as surviving
Managment of Ectopic Pregnancy
• expectant treatment
• pharmacotheraphy (Methotrexate)
• surgery
Managment of Ectopic Pregnancy
„ expectant treatment”
Indications
• low HCG level
• ectopic gestation < 4 cm in diameter
• ampullary localization
• no bleeding
• no symptoms of rupture
Managment of Ectopic Pregnancy
Pharmacotheraphy
Methotrexate (folinic acid antagonist)
Indications HCG level < 10 000 mIU/ml• ectopic gestation < 4cm in diameter• cervix, ovarium, intramural localization
for 20% of women 1 dose is enough
Managment of Ectopic Pregnancy„surgery”
• Unruptured
- Laparoscopy
- salpingtomy
- salpingectomy
- Laparotomy- surgical techniques
• Ruptured- Laparoscopy - Laparotomy- surgical techniques
- salpingectomy
Ectopic Pregnancy
• Rh- negative mothers with ectopic pregnancy should recieve Rh immune globulin to prevent Rh sensitisation
• risk of Rh sensitisation < 1%
Pelvic Inflammatory Disease
PID is a polymicrobal infection involving endogenous aerobes and anaerobes as well as sexually transmitted pathogens.
PID
Variables that increase the incidence of PID:
• teenage years• multiple sexual partners• previous PID• intrauterine device (two months after insertion
only)• uterine instrumentation
PID- etiology
• Chlamydia trachomatis
• Neisseria gonorrhoeae
• Escherichia colli, Proteus, Klebsiella, Streptococcus- endogenous aerobes
• Bacteroides, Peptostreptococcus, Peptococcus- endogenne anaerobes
• Actinomyces israeli- IUCD
Chlamydia trachomatis(intracellular parasite)
Infection rates• 20-40% of sexually active women have
antibodies to Chlamydia• five times higher in women with three or more
partners• four times higher in women using no
contraception or nonbarrier methods• up to 20% has asymptomatic cervical infection
Chlamydia trachomatis(intracellular parasite)
Symptoms• subtle and nonspecific physical findings• mucopurulent cervicitis• acute urethritis• salpingitis• PID• Fitz-Hugh-Curtis syndrome (perihepatitis)
– localized fibrosis with scarring of the liver and adjacent peritoneum
Chlamydia trachomatis(intracellular parasite)
Infertility and ectopic pregnancy
• mild form of salpingitis with insidious symptoms
• established infection remain active for many months
• increasing tubal damage
Chlamydia trachomatis(intracellular parasite)
• infection is suspected on clinical grounds
• culture results (obtained after 48-72 h) confirms the diagnosis– ELISA performed on cervical secretions
95% specificity
– monoclonal fluorescent antibody test carried out on dried specimens
90% sensitivity; 95% specificity;
Neisseria gonorrhoeae(Gram-negative intracellular diploccocus)
• Easy acquired – single encounter with infected partner leads to infection 80-90% of the time
• First signs or symptoms of infection:– 3-5 days after exposure, often mild– malodorous purulent discharge from the urethra, Skene`s
duct, cervix, vagina or anus– „mucopus” – greenish or yellow discharge from the cervix– infection of the Bartholin`s gland
• Fitz-Hugh-Curtis syndrome• 15% of women with N. gonorrhoeae develop
acute pelvic infection (PID)
Neisseria gonorrhoeae(Gram-negative intracellular diploccocus)
Laboratory diagnosis:
• cultures obtained from the cervix, uretra, anus, pharynx
• Thayer-Martin agar plates kept in
CO2-rich environment – 80-90% sensitivity
PID
Hager’s criteria for diagnosing acute PID:
• history of lower abdominal pain or tenderness
• cervical motion tenderness and adnexal tenderness
(all necessary for diagnosis !)
PIDHager’s criteria for diagnosing acute PID:• fever > 38°C• leukocytosis > 10 000 WBC/mm3
• culdocentesis fluid containing WBCs or bacteria
• inflammatory mass on pelvic examination or USG
• evidence of gonococcus or Chlamydia on cervical Gram’s stain
(one or more of the objective findings necessary for diagnosis !)
PID
Clinical diagnosis of PID is often imprecise
• white cell count above 10 000 > 50% of patients • positive chlamydia cultures ~ 30% of patients • positive gonorrhea cultures ~ 25% of patients
PID
Correct diagnosis in cases of misdiagnosis of PID• acute appendicitis 28% of cases• endometriosis 17% of cases• corpus luteum bleeding 12% of cases• ectopic pregnancy 11% of cases• adhesions 7% of cases• „other” 28% of cases
PIDIndications for hospitalization
• presence of tuboovarian complex or abscess (TOA)
• uncertain diagnosis• significant gastrointestinal symptoms• nulliparity• pregnancy
PID
Recommendations for hospitalized patients(no pelvic mass, IUD, recent history of pelvic instrumentation)
• cefoxitin 2g IV q6h
• cefotetan 2g IV q12h + doxycycline 100 mg q12h
regimen continued for at least 48 hours after the patient clinically improves
PID
Recommendations for hospitalized patients(pelvic mass, IUD, recent history of pelvic instrumentation)
• clindamycin 900 mg IV q8h + gentamycin 2 mg/kg IV,
followed by gentamycin 1,5 mg/kg IV q8h
regimen continued for at least 48 hours after the patient clinically improves
PID
Tests that should be also obtain:
• Trichomonas vaginalis screening (wet preparat)
• serology syphilis screening
• HIV screening
PID
If outpatient treatment is used, the patient must be reexamined after 48 to 72 hours.
If the response for the treatment is suboptimal, the patient need to be hospitalized and intravenous antibiotics initiated.
PID
Recomendation for outpatient therapy
• cefoxitin 2g IM + probenecid 1g PO• ceftriaxon 250 mg IM + doxycycline 100 mg
PO q12h for 10 - 14 days• tetracycline 500 mg PO q6h for 10 - 14 days• erythromycin 500 mg PO q6h for 10 - 14
days
PID
Laparoscopy
- diagnosis of PID is in doubt
- the patient does not respond to medical therapy
PID
Laparoscopic criteria for acute PID
minimum criteria
• erythema of fallopian tubes
• edema and swelling of fallopian tube
• exudate from fimbria or on serosa of fallopian tube
PID
Scoring
• mild: minimum criteria, tubes freely movable and patent
• moderate: more marked , tubes not freely movable, patency uncertain
• severe: inflammatory mass
PID
Complications of PID• formation of tuboovarian abscess (TOA)• ectopic pregnancy (rate seven to ten times
normal)
• infertility (rate increase proportional to the number of episodes of acute PID)
• chronic pelvic pain (approximately 20%)
• recurrent PID (approximately 25%)
PID
Surgical treatment of PID (extirpation)
• Ruptured TOAs,
• TOAs that do not respond to medical therapy within 4 to 5 days
• TOAs that results in chronic pain
teenangermultiple sexual partnersprevious PIDIUDuterin instrumentationpainpelvic tendernessfevermassvaginal discharge
PID
WBCChlamydial culture or antigen detection testGonorrhea cultureSyphilis wet prep., serologyHIVUSG
Outpatient treatment
Hospitalization
Antibiotic
Response
No response
Discharge onantibiotic
Laparoscopy
Complications
Tuboovarianabscess
Operative drainage
Ectopicpregnancy
Infertility
Chronicpain
Recurent PID
PID
Therapy of the symptomatic as well as asymptomatic male partners is an integral part of treatment PID.
PID
Variables that decreases the incidence of PID
• use of mechanical contraceptives
• use of oral contraceptives
Other causes of bleeding into the abdominal cavity
• Rupture of follicular cyst
• Corpus hemorrhagicum
• Rupture of ovarian tumor
• Postoperation bleeding
Adnexal torsion (10%)
DEFINITION:
partial or complete rotation of the ovary, fallopian tube or both, on its vascular pedicle.
Adnexal torsion
Etiology
• 50-60% - ovarian and/or adnexal mass
• increased weight of the ovary
• reduced venous return from the ovary
Adnexal torsion
All ages, usually:
• women in their mid 20s
• postmenopausal women
• 20% of cases of torsion occur during prgnancy
Adnexal torsionSymptoms – variable and nonspecific
- acute abdominal pain- nausea, vomiting- anorexia,- peritoneal signs- diarrhea- hypovolemic shock
½ of the patients have had a similar episode in the pastapproximately ½ of the patients have a palpable mass
Adnexal torsion1. Sonography
• multiple peripheral cysts in an enlarged ovary – relatively specific
• free pelvic fluid• adnexal cysts and tumors
2. Colour Doppler• shows whether the vascular flow is impaired:• absence of vascular flow is not specific for torsion• presence of vascular flow does not rule out torsion (flow may be seconadry to the dual blood supply of the ovary or from venous thrombosis
which causes symptoms before the loss of arterial flow)
3. CT, MRI
Adnexal torsiondifferental diagnosis
Based on clinical presentation:
• appendicitis
• intussusception
• gastroenteritis
• pyelonephritis
• salpingititis
• inflammatory bowel disease
Based on sonography:
• hemorrhagic ovarian cyst
• ovarian mass or neoplasm
• parovarian cyst
• pelvic inflammatory disease
• abscess
Adnexal torsionmanagement
• surgery• oophoropexy (if the ovary is thougt to be viable
during surgery)
– preserves the ovary, reduces the incidence of reccurent torsion
– also for contralateral ovary to prevent its subsequent torsion
Rupture of ovarian cyst (3%)
• Bleeding into abdominal cavity
• Symptoms
- acute abdominal pain
- peritoneal signs
- hypovolemic shock
Diagnosis
• General examination
• Gynecological examination
• USG
• Abdominal X- ray
• Laboratory tests
Vaginal bleeding
• Injury- sexual intercorses • Abortion • Carcinoma Cervical carcinoma
– Endometrial carcinoma – Vaginal carcinoma – Myomas
• Functional bleeding
Gynecological iatrogenic emergencies
• Laparotomy
• Laparoscopy
• Other (D&C; HSG)
Laparoscopy, laparotomy – iatrogenic complications
• Anesthesial complications
• Postoperation bleeding
• Mechanical obstruction
• Paralytical obstruction
• Peritonitis
Sepitic Pelvic Thrombophlebitis
• Multiple bacteria infection• Septic thrombosis in vessels• Subseqent microembolisation in lungs or other
organs by way of the inferior vena cava is possible• Symptoms: residual fever and tachycardia • Antibiotics and anticoagulation therapy is
recommended for at least 7 and up to 30 days
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