german measles in pregnancy
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German Measles in Pregnancy
Dr. Margarita Isabel Amoroso-Artes
Department of OB/GYN
Davao Medical Center
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Minor importance in absence of pregnancy During pregnancy:
Directly responsible for abortion & severe congenital malformations
Congenital Rubella Syndrome
TERATOGENIC
12 weeks AOG- 80%
13-14 weeks- 54%
End of 2nd trimester- 25%
Eye defects- cataract & glaucoma Heart disease- PDA & Peripheral pulmonary
artery stenosis Sensorineural deafness- most common single
defect CNS- microcehaly, developmental delay, MR,
meningoencephalitis Purpura Hepatosplenomegaly & jaundice Radiolucent bone disease
Neonates with the disease
Continue to she the virus for months
Threat to other infants as well as to adults
Diagnosis Mild febrile illness
Generalized maculopapular rash
Arthralgias/arthritis Lymphadenopathy
Suboccipital Postauricular cervical
conjunctivitis
Incubation period- 12 t0 23 days
20-50% asymptomatic
Viremia precedes clinical signs by a week
Adults are infectious during viremia through 5-7 days of rash
Clinical
ELISA- specific IgM antibody 4-5 days after onset Persist 8 weks after rash appearance
ELISA- IgG antibody Peaks 1-2 weeks after rash onset If specimen obtained 10 days after rash:
failure to differentiate very recent disease & preexisting immunity
Prevention
25% in the US susceptible (large epidemics have disappeared)
Congenital Rubella still common in developing countries
Goal: ERADICATION
Immunization of the adult population
MMR- offered to women of childbearing age
Vaccination Part of general routine medical checkup In family planning settings Provided routinely to unimmunized women after
hospitalization, childbith or abortion
End
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