gemc - gastrointestinal bleeding in the pediatric patient
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This is a lecture from the Ghana Emergency Medicine Collaborative (GEMC). To download the editable version (in PPT), to access additional learning modules, or to learn more about the project, see http://openmi.ch/em-gemc. Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/.TRANSCRIPT
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Project: Ghana Emergency Medicine Collaborative Document Title: Gastrointestinal Bleeding in the Pediatric Patient Author(s): Michele Carney (University of Michigan), M.D., 2011 License: Unless otherwise noted, this material is made available under the terms of the Creative Commons Attribution Share Alike-3.0 License: http://creativecommons.org/licenses/by-sa/3.0/
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Gastrointes-nal Bleeding in the Pediatric Pa-ent
Michele M. Carney, M.D. Combined EM Resident/PEM Fellow Conference November 9, 2011
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Objec-ve
Review the causes of upper and lower gastrointes-nal bleeding in the pediatric popula-on. Provide some diagnos-c tools and management strategies for the most common offenders.
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Introduc-on
• Bloody emesis or bloody stools are very anxiety provoking for parents
• Gastrointes-nal bleeding is common in the pediatric popula-on.
• Fortunately, most are from non-‐serious causes – Anal fissures, infec-ous, milk protein allergy, oral trauma, prolapse gastropathy or esophagi-s/gastri-s
• Hemodynamically significant bleeding is uncommon.
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Upper GI bleed
• Bleeding proximal to the ligament of Treitz. – Presents with:
• Hematemesis – vomi-ng bright red blood or coffee-‐ground material.
• Melena – black, tarry stools. – Time for gastric juices and bacteria degrada-on.
• If massive then hematochezia. – Shorter transit -me.
– More blood loss than lower GI bleeding.
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Ligament of Treitz
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Source undetermined
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Lower GI bleed
• Bleeding distal to the ligament of Treitz – Presents with:
• Hematochezia – bright red blood per rectum • Maroon stools – profuse bleed from distal small bowel
– The higher the bleed, the darker the stool
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Is it really blood?
• Hemoccult kits – Used to test stool for blood. – Employs a peroxidase-‐like ac-vity in hemoglobin to oxidize with the reagent changing the color to blue.
– False posi-ve: red meat, horseradish, turnips, iron, tomatoes and fresh red cherries.
– False nega-ves: Vitamin C, storage for more than 4 days or outdated reagents or cards.
– False nega-ves occur with emesis due to its acidic nature.
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Is it really blood?
– Gastroccult kits • Used to determine if blood is present in vomit. • Neutralizes the gastric acid in emesis making it more accurate.
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Clinical Evalua-on • Hemodynamic stability
– Vitals • Tachycardia, orthosta-c, hypotensive..
– Perfusion • Mental status, urine output, capillary refill…
• Blood in the oropharynx? • Hernia? • Skin exam: bruises, petechia, telangiectasia , jaundice?
• Blood/fissures at the anus? 11
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Causes: Neonates Neonates (less than 1 month):
– Upper • Hemorrhagic disease of the newborn • Swallowed maternal blood • Stress gastri-s
– Lower • Anal fissure • Allergic coli-s • Hirshsprungs with enterocoli-s • Malrota-on with volvulus • Necro-zing enterocoli-s
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Case #1
• 5 day old ex)38 week breasfed neonate with hematemesis.
Vitals: • Temp: 36.5 • HR: 150 • RR:35 • BP: 70/45
Sick or Not sick
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Upper GI bleed: not sick • Swallowed maternal blood from delivery or breast feeding – Apt test (don’t do at UM)
• APT (alum-‐precipitated toxoid) test • gastric contents of neonate mixed with 1% sodium hydroxide
• maternal hemoglobin turns rusty brown – Kleihauer-‐Betke: sample exposed to acid to eliminate adult hemoglobin (quan-ta-ve test)
– Mom usually gives great history of painful nursing
• Gastri-s from stressful birth
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Upper or Lower GI bleed
• If the baby was born at home or mom refused Vitamin K shot Hemorrhagic disease of the newborn. – Vitamin K deficiency – Peaks 48 to 72 hours
• Other coagulopathies – Liver disease – Metabolic disease
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Upper GI bleed
• If the history is unclear it is reasonable to check: – CBC – Coags – Chemistry with liver enzymes
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Case #2 • 5 day old ex) 36 week neonate presents with bloody stool.
• Vitals: – Temp:37 – Heart rate: 190 – Respiratory rate: 72 – Blood pressure 76/45 – Pulse ox: 97% on room air
Sick or Not sick?
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18 Source undetermined
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Necro-zing enterocoli-s (NEC)
• Overall rate of NEC in full term infants is approximately 0.7 per 1000 live births, which is almost 10% of all cases
• Mean age to presenta-on for full term is 4-‐5 days
• Mean age to presenta-on for premature is 10 days
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Necro-zing enterocoli-s (NEC)
• Most common acquired gastrointes-nal disorder
• Small (most oken distal) and/or large bowel becomes injured
• Intramural air, and may progress to frank necrosis with perfora-on Sepsis/Death
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Necro-zing enterocoli-s (NEC)
• Cause is unknown – Intes-nal ischemia – Coloniza-on by pathogenic bacteria – Excess protein substrate in the intes-nal lumen
1. Santulli TV, Schullinger JN, Heird WC, et al. Acute necro-zing enterocoli-s in infancy:a review of 64 cases. Pediatrics 1975;55(3):376–87.
2. Kosloske AM. Pathogenesis and preven-on of necro-zing enterocoli-s: a hypothesis basedon personal observa-on and a review of the literature. Pediatrics 1984;74(6):1086–92.
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Necro-zing enterocoli-s (NEC)
• Bowel rest • Nasogastric tube decompression • Fluid resuscita-on • Blood and platelet transfusion if needed • Broad-‐spectrum an-bio-cs • Pediatric Surgery Consult
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Case #3
• 4 week old male with poor feeding today presented with black stool
• Vitals: – Temp: 37.5 – HR: 170 – RR: 45 – BP: 85/47 – Pulse ox: 97%
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Case #3
In the emergency department, pa-ent’s vomit was green
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Malrota-on with volvulus
25 Source undetermined
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26 Source undetermined
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Malrota-on
• 14 year old boy with recurrent abdominal pain and bilious emesis
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Source undetermined
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Malrota-on
• Incidence of malrota-on is 1 in 500 live births • 60% of volvulus cases occur in the first month of life; 75% by 1 year of age
• Volvulus occurs in 70% of neonatal malrota-on cases
• No race predilec-on; male:female is 3:2 • Morbidity: short-‐gut, TPN, SBO, recurrent volvulus
• Mortality: 3-‐9%
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Malrota-on
• Malrota-on with midgut volvulus is the most cri-cal surgical emergency in the newborn period
• Usually presents within the first weeks of life • Presents with the sudden onset of melena and bilious vomi-ng in a previously health infant
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Normal
• 4th and 5th week of gesta-on – Duodenal intes-nal loop comes out and twists 90 degrees. Counterclockwise.
– Cecal loop rotates 180 degrees. – Total of 270 degrees – Ileocecal valve in right lower quadrant – Ligament of Treitz in the lek upper quadrant. – Long and strong mesenteric base
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Malrota-on
• Duodenal intes-nal loop comes out but does not rotate.
• Cecal loop rotates 90 degrees instead of 180 degrees.
• Cecum ends up in the mid-‐upper abdomen. – Fixed by Ladd’s bands to the right lateral abdominal wall.
• Causes obstruc-on to duodenum.
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Children (> 1 month to 2 years)
• Upper
– Esophagi-s/gastri-s – Hypertrophic pyloric stenosis – Pep-c ulcer disease – Esophageal varices from portal hypertension
• Lower – Anal fissure – Milk protein allergy – Intussuscep-on – Hernia – Meckel’s diver-culum – Malrota-on – Gastroenteri-s
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Upper GI bleed
• Significant bleeding regardless of the cause requires inves-ga-on – Gastric lavage to determine con-nua-on of bleeding
– Proton pump inhibitors (IV) shown to reduce the risk of rebleeding of ulcers, hospital stay and need for transfusion (adult studies)
– H2-‐ receptor antagonists not found to be beneficial (adult studies)
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Upper GI bleed
– Octreo-de for esophageal varices * • Portal venous inflow and intravariceal pressure • 1 microgram/kg over 5 min. then 1 microgram/kg/hr • No great studies in pediatrics • Bleed from esophageal varices has a 30% mortality rate**
– Endoscopy *Octreo-de in Pediatric Pa-ents*Janice B. Heikenen, †John F. Pohl, ‡Steven L. Werlin, and §John C. Bucuvalas Journal of Pediatric Gastroenterology and Nutri6on 35:600–609 © November 2002 Lippincov Williams & Wilkins, Inc., Philadelphia **Management of portal hypertension in children. Mile- E, Rosenthal P. Curr Gastroenterol Rep. 2011 Feb;13(1):10-‐6. University of California, San Francisco, San Francisco, CA 94143-‐0136, USA. [email protected]
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Upper GI bleed
• Resuscita-on – If hemodynamically compromised
• Two large bore IV • 20cc/kg of normal saline given • Packed red blood cells given 15 cc/kg maintain hematocrit near 30 g/dl
• 5cc/kg PRBC raise Hct 5% • Fresh frozen plasma to correct coagula-on abnormali-es 15 cc/kg
• Platelet transfusion for platelets < 50
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Case #4
• 2 year old female with choking episode, now with blood streaked vomitus
Vital Signs: Temp:36.6 HR: 135 RR:28 BP:110/60 Pulse ox: 98% on room air
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Lower GI bleed
• Anal fissure • Gastroenteri-s • Intussuscep-on • Milk protein allergy • Meckel’s diver-culum • Malrota-on
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Case #5
15 month old female with chief complaint of lethargy. Vital Signs: Temp: 37.5 HR: 150 RR: 32 BP 90/54 Pulse ox: 97% room air
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Intussuscep-on
• Most common cause of bowel obstruc-on ages 3 months to 5 years
• 50% occur between 3 months to 1 year • 80% occur by 2 years • Peak incidence at 7-‐8 months • 2-‐4 cases per 1000 live births • Male:female is 2:1 • Mortality 1%
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Intussuscep-on: Presenta-on
• Severe colicky pain, legs and knees flexed • The infant may ini-ally be comfortable and play normally between the episodes but then progressively weaker and lethargic
• Less then 15% have the triad of pain, palpable sausage mass and currant jelly stools
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Intussuscep-on: Pathophysiology
• Telescoping of ileum into colon ileum compressed venous conges-on swelling arterial compression ischemia
Bloody stools
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Intussuscep-on: Ultrasound
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Source undetermined
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Intussuscep-on
• Crescent sign LUQ
• Target sign RUQ
• Loss of hepa-c outline
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Source undetermined
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Intussuscep-on
• Study in South Africa showed that Burkiv lymphoma presented as intussuscep-on
Intussuscep-on as a presen-ng feature of Burkiv lymphoma: implica-ons for management and outcome. England RJ, Pillay K, Davidson A, Numanoglu A, Millar AJ. Department of Paediatric Surgery, Red Cross War Memorial Children's Hospital, University of Cape Town, Klipfontein Road, Rondebosch, Cape Town, 7700, South Africa, [email protected].
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Case # 6
• A six week old formula fed infant presents with two stools with a small amount of blood mixed with mucous
Vitals: • Temp: 37 • HR: 130 • RR: 32 • BP: 72/49
Sick or not sick 45
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Cows milk protein allergy
• Immunologic hypersensi-vity reac-on to milk proteins
• 2-‐6% formula fed • 0.5% breast fed infants • 50-‐60% present with gastrointes-nal/skin symptoms
• 30% respiratory symptoms
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Management
• Removal of cow’s milk from the diet • 30% also allergic to soy • Need hydrolyzed protein formula
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Finish Study The study involved 40 consecu-ve infants (mean age: 2.7 months) with visible rectal bleeding during a 2-‐year period at the Tampere University Hospital Department of Pediatrics • 18% turned out to be allergic coli:s otherwise no cause was found • Suggested virus played a role
Rectal bleeding in infancy: clinical, allergological, and microbiological examina:on. Arvola T, Ruuska T, Keränen J, Hyöty H, Salminen S, Isolauri E. Department of Paediatrics, Tampere University Hospital, Tampere, Finland. [email protected]
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Case #7
11 year old male with lethargy and pale appearance. Vital signs: Temp: 37.7 HR:140 BP: 90/60 Pulse ox: 95% room air
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Case #7
• Labs revealed: hemoglobin level of 4.8 g/dl, and a hematocrit of 14.6%
By the way…he has been having bloody stools for 2 weeks
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Meckel’s Diver-culum • Acid secre-ng mucosa • 2% (of the popula-on) • 2 feet (from the ileocecal valve) • 2 inches (in length) • 2% are symptoma-c • 2 types of common ectopic -ssue (gastric and pancrea-c)
• 2 years is the most common age at clinical presenta-on
• 2 -mes more boys are affected.
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Meckel’s Diver-culum
• infants and preschool children – slight or massive GI bleeding -‐ painless
• incomplete oblitera-on of omphalmomestenteric duct – ectopic gastric mucosa in the remnant – ulcera-on of mucosa across from the diver-culum
• Meckel Scan
– Techne-um pernechnetate has affinity for gastric mucosa
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GI bleeding in Adolescents Upper • Pep-c ulcer/gastri-s • Prolapse (trauma-c) gastropathy secondary to emesis • Mallory-‐Weiss syndrome • Coagulopathy • Esophageal varices
Lower • Bacterial enteri-s • Inflammatory bowel disease • Colonic polyps • Anal fissure • Meckel’s diver-culum
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Case # 8
• 2 year old male with history of asthma has ear pain for 2 days, now bever aker taking omnicef. Mom is concerned because she found blood in his stool.
• Vitals: – 37.5/122/23/97% on room air 96/63
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Quiz
• 2 year old boy with bilious vomi-ng and bloody stools since last night. Presents today moderately ill, dehydrated with scaphoid abdomen and no bowel sounds. Aker ABC what is your next step?
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• A. Ultrasound of abdomen • B. Upper GI • C. CT of the abdomen • D. Meckel scan • E. Upper endoscopic exam
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• 12 year old boy S/P Kasai for biliary atresia presents with pruri-s, mild icterus and hematemesis. Physical shows an anxious boy with normal vital signs, hepatosplenomegaly and prominent venous pavern over the abdomen. Stools are black and guaic posi-ve. Cause of hematemesis:
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• A. Pep-c Ulcer disease • B. Esophageal varices • C. Posterior nasal bleeding • D. Prolapse gastropathy • E. Thrombocytopenia
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• 5 year old with intermivent, painless bright red blood per rectum associated with bowel movements for the past 3 months. Inspec-on of the anus shows no fissures but blood on rectal exam. Most likely cause:
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• A. Intussuscep-on • B. Juvenile polyp • C. Meckel diver-culum • D. Pep-c Ulcer disease • E. Ulcera-ve coli-s
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• 5 year old girl complains of severe perianal pain on stooling. Physical shows an intensely red, warm and tender perianal -ssue. Rectal shows gross blood. What organism is causing these findings?
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• A. Campylobacter • B. C. Diff • C. Streptococcal • D. Salmonella • E. Shigella
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